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SSA antibody

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https://www.readbyqxmd.com/read/29655640/how-are-ocular-signs-and-symptoms-of-dry-eye-associated-with-depression-in-women-with-and-without-sj%C3%A3-gren-s-syndrome
#1
John A Gonzales, Annie Chou, Jennifer R Rose-Nussbaumer, Vatinee Y Bunya, Lindsey A Criswell, Caroline H Shiboski, Thomas M Lietman
PURPOSE: To determine whether ocular phenotypic features of keratoconjunctivitis sicca (KCS) and/or participant-reported symptoms of dry eye disease are associated with depression in women participants enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA). DESIGN: Cross-sectional study. METHODS: Women enrolled in the SICCA registry from 9 international research sites. Participants met at least one of five inclusion criteria for registry enrollment (including complaints of dry eyes or dry mouth, a previous diagnosis of Sjögren's syndrome (SS), abnormal serology (positive anti-Sjögren's syndrome-related antigen A and/or B (anti-SSA and/or anti-SSB), or elevated anti-nuclear antibody and rheumatoid factor), bilateral parotid gland enlargement, or multiple dental caries)...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#2
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29602165/sonographic-evaluation-of-salivary-glands-in-juvenile-sj%C3%A3-gren-s-syndrome
#3
Vanessa Ramos Guissa, Evelyne Lopes Martinelli, Letícia Maria Kolachinski Raposo Brandão, Leandro Diniz Garcia, José Roberto Provenza, José Alexandre Mendonça
IIntroduction: Sjögren's syndrome in childhood is a rare autoimmune disease and mostly under-diagnosed. The aim of this study is to highlight the importance of ultrasonographic assessment of the salivary glands in children with recurrent parotitis and positive autoantibodies. Two cases of ultrasonographic patterns typical of Sjögren's syndrome have been described below. Case 1: Female, 7 years old, reporting for 2 years recurrent parotitis, xerophthalmia, xerostomia, polyarthralgia and fever. Immunological tests were positive for antinuclear antibodies, rheumatoid factor, anti-SSA/Ro and anti-SSB/La...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29579358/a-22-year-old-woman-with-systemic-lupus-erythematosus-presents-with-two-damaged-kidneys-one-seizure-no-platelets-and-many-possible-diagnoses
#4
Lisa Zickuhr, Leal C Herlitz, Soumya Chatterjee
A 22-year-old woman with a history of systemic lupus erythematosus (SLE) was admitted with progressive edema. Two years before hospitalization, a local rheumatologist diagnosed her with SLE based on a syndrome of oral ulcers, inflammatory arthritis, discoid lupus lesions, and Raynaud phenomenon. Serum analysis revealed high-titer anti-nuclear antibodies, the presence of anti-SSA, anti-SSB, anti-Smith, anti-RNP, anti-histone, and anti-double-stranded DNA antibodies, and low complement (C3 and C4) levels. Hydroxychloroquine and topical clobetasol ointment were started...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29556334/potential-red-flag-identification-of-colorectal-adenomas-with-wide-field-fluorescence-molecular-endoscopy
#5
Elmire Hartmans, Jolien J J Tjalma, Matthijs D Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana E Silva de Oliveira Nery, Sjoerd G Elias, Arend Karrenbeld, Elisabeth G E de Vries, Jan H Kleibeuker, Gooitzen M van Dam, Dominic J Robinson, Vasilis Ntziachristos, Wouter B Nagengast
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas...
2018: Theranostics
https://www.readbyqxmd.com/read/29542345/epratuzumab-for-the-treatment-of-systemic-lupus-erythematosus
#6
Daniel Geh, Caroline Gordon
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. There are three drugs licensed for the treatment of lupus: corticosteroids, hydroxychloroquine and belimumab. Immunosuppressants such as azathioprine, methotrexate and mycophenolate are also used. Despite these treatments there is still considerable morbidity. New treatments are needed for the management of active lupus. Epratuzumab a humanized IgG1 monoclonal antibody that targets CD22 resulting in selective B cell modulation that has been considered a potential treatment for SLE...
March 20, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29521043/clinical-and-immunological-characteristics-of-polish-patients-with-systemic-lupus-erythematosus
#7
Martyna Tomczyk-Socha, Hanna Sikorska-Szaflik, Marek Frankowski, Karolina Andrzejewska, Agnieszka Odziomek, Magdalena Szmyrka
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with varied clinical manifestations, which creates difficulties and delays in establishing a diagnosis. OBJECTIVES: The aim of this study was to evaluate the prevalence and nature of the clinical symptoms of SLE, both at the onset of the disease and in its further course. An attempt to assess the immunological characteristics of the patients and to analyze autoantibodies variability over time was also made...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29460892/-coexpression-of-cd44-and-ki-67-in-colon-s-neoplast
#8
N A Oleynikova, O A Kharlova, P G Malkov, N V Danilova
AIM: the evaluation of Ki-67 and CD44 expression in the 'serrated' polyps of the colon and comparison them with adenocarcinomas and tubular and tubule-villous adenomas of the colon. MATERIAL AND METHODS: The study is including 49 'serrated' polyps, 34 tubular (AT) and tubulo-villous (ATV) adenomas and 32 adenocarcinomas of the colon. Antibodies CD44 and Ki-67 were used as immunohistochemical markers in this study. RESULTS: A statistically significant difference (p<0...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29456945/audiological-profile-in-primary-sj%C3%A3-gren-s-syndrome-in-a-tertiary-care-setting-and-its-clinical-implications
#9
C V Thanooja, Ann Mary Augustine, Anjali Lepcha, Pulukool Sandhya, Amit Kumar Tyagi, Debashish Danda, Achamma Balraj
This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren's syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren's syndrome in our tertiary care hospital. All patients underwent a puretone audiogram, tympanogram and acoustic reflex testing...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29431056/characteristics-of-systemic-lupus-erythematosus-in-a-sample-of-the-egyptian-population-a-retrospective-cohort-of-1109-patients-from-a-single-center
#10
K T El Hadidi, B M Medhat, N M Abdel Baki, H Abdel Kafy, W Abdelrahaman, A Y Yousri, D H Attia, M Eissa, D El Dessouki, I Elgazzar, F T Elgengehy, N El Ghobashy, H El Hadary, G El Mardenly, H El Naggar, A M El Nahas, R M El Refai, H Allah El Rwiny, R M Elsman, M Galal, S Ghoniem, L A Maged, S M Sally, H Naji, S Saad, M Shaaban, M Sharaf, N Sobhy, R M Soliman, T S El Hadidi
Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can vary among different ethnic and racial groups. Objective The objective of this paper is to study the prevalence of various manifestations of SLE in a sample of the Egyptian population. Patients and methods Information in this study was derived from the medical records of SLE patients who sought medical advice at a private clinic in Cairo from January 1980 to June 2016. Results This study included 1109 SLE patients, of whom 114 (10...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29427827/nailfold-capillaroscopy-in-systemic-lupus-erythematosus-a-systematic-review-and-critical-appraisal
#11
REVIEW
Maurizio Cutolo, Karin Melsens, Sara Wijnant, Francesca Ingegnoli, Kristof Thevissen, Filip De Keyser, Saskia Decuman, Ulf Müller-Ladner, Yves Piette, Valeria Riccieri, Nicola Ughi, Els Vandecasteele, Amber Vanhaecke, Vanessa Smith
Nailfold capillaroscopy is an easy, non-invasive technique to assess microvascular involvement in rheumatic diseases. Multiple studies describe capillaroscopic changes in systemic lupus erythematosus (SLE), including a wide range of non-specific findings. On behalf of the European League Against Rheumatism (EULAR) study group on microcirculation in rheumatic diseases, a systematic review was done to obtain all original research studies (in English) in which SLE patients had capillaroscopy. Forty such studies are identified...
February 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29427009/anti-tubulin-%C3%AE-1c-autoantibody-in-systemic-lupus-erythematosus-a-novel-indicator-of-disease-activity-and-vasculitis-manifestations
#12
Xiaozhen Zhao, Yongjing Cheng, Yuzhou Gan, Rulin Jia, Lei Zhu, Xiaolin Sun
A variety of autoantibodies has been involved in the pathogenesis of systemic lupus erythematosus (SLE), some of which are well known and applied as disease biomarkers. This study aimed to determine the prevalence of a novel autoantibody, anti-tubulin-α-1C, in patients with SLE and investigate its clinical significance. Anti-tubulin-α-1C autoantibody levels were determined by enzyme-linked immunosorbent assay (ELISA) in 128 SLE patients, 38 primary Sjögren's syndrome (pSS) patients, and 106 healthy controls (HCs)...
February 9, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29380161/cerebellar-involvement-in-patients-withprimary-sj%C3%A3-gren-s-syndrome-diagnosis-and-treatment
#13
Huaxia Yang, Yinghao Sun, Lidan Zhao, Xuan Zhang, Fengchun Zhang
The aim of this study is to describe the clinical features of cerebellar involvement in patients with primary Sjögren's syndrome (pSS). We retrospectively analyzed the manifestations, treatments, and outcomes in patients with pSS-cerebellar complication in Peking Union Medical College Hospital and cases reported in literature. Altogether 13 patients were identified. They were 2 males and 11 females with a mean age at disease onset of 45.2 ± 14.6 years. Nine (69.2%) patients went to the clinic because of ataxia, and pSS was not suspected until accidental screening for autoantibodies...
January 29, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29359173/immune-myopathies-with-perimysial-pathology-clinical-and-laboratory-features
#14
Robert C Bucelli, Alan Pestronk
Objective: Immune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP. Methods: This is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, for comparison, 20 patients with dermatomyositis with vascular pathology (DM-VP)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29303768/detection-of-autoantibodies-to-the-p200-epitope-of-ssa-ro52-antigen-a-comparison-of-two-laboratory-assays
#15
Elena Mattia, Ariela Hoxha, Marta Tonello, Maria Favaro, Teresa Del Ross, Antonia Calligaro, Anna Ghirardello, Amelia Ruffatti
BACKGROUND: Anti-p200 antibodies have been receiving growing interest in view of findings associating their presence to risk of fetal autoimmune congenital heart block (CHB). The study compares and evaluates the performance of two assays currently being used for their detection. METHODS: One hundred and sixteen pregnant women positive for anti-SSA/Ro52 antibodies were considered as the study population. Fifty women negative for anti-SSA/Ro52 antibodies were considered as the control population...
January 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29290190/determination-of-specificity-and-pattern-of-antinuclear-antibodies-ana-in-systemic-rheumatic-disease-patients-positive-for-ana-testing
#16
Hamid Nawaz Tipu, Muhammad Mukarram Bashir
OBJECTIVE: To determine probability of finding antinuclear antibodies (ANA) and anti extractable nuclear antigens (ENA) positive samples and associating ANA patterns with anti-ENA reactivities among a consecutive cohort of samples of systemic rheumatic disease patients referred for ANA testing. STUDY DESIGN: Prospective cohort study. PLACE AND DURATION OF STUDY: Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to June 2016...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29274563/iga-anti-%C3%AE-2-glycoprotein-i-antibodies-experience-from-a-large-center
#17
Alexandru Vlagea, Dora Pascual-Salcedo, Rita Álvarez Doforno, Paz Lavilla, Jesús Diez, Beatriz Padilla Merlano, María V Cuesta, Antonio Gil
OBJECTIVE: IgG and IgM antibodies directed at β2-glycoprotein I are included in the classification criteria for the antiphospholipid syndrome (APS) while the IgA antibodies against β2-glycoprotein I (IgA aβ2GPI) are not. Conflicting data about the significance of IgA aβ2GPI and APS manifestation can be found and more studies are necessary in order to define the diagnostic value of IgA aβ2GPI. In the present article, we investigated the possible role of IgA aβ2GPI as marker of APS...
February 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29260117/parallel-ocular-and-serologic-course-in-a-patient-with-early-sjogren-s-syndrome-markers
#18
Lam Phung, Ivonne V Lollett, Raquel Goldhardt, Janet L Davis, Larry Young, Dana Ascherman, Anat Galor
Purpose: To report on a case of a young female with progressing dry eye symptoms and evolving autoimmune markers consistent with a presentation of early Sjogren's syndrome (SS). Observations: A 32 year-old female presented with chronic dry eye symptoms refractory to artificial tears. Slit lamp examination revealed punctate epithelial erosions, decreased tear break-up time, and decreased tear lake bilaterally. Initial tests for ocular surface inflammation (InflammaDry, Quidel, San Diego) and systemic autoantibodies (antinuclear antibodies, anti-SSA/Ro and anti-SSB/La) were negative...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29251022/impact-of-double-positive-for-anti-centromere-and-anti-ss-a-ro-antibodies-on-clinicopathological-characteristics-of-primary-sj%C3%A3-gren-s-syndrome-a-retrospective-cohort-study
#19
Yasunori Suzuki, Hiroshi Fujii, Hideki Nomura, Ichiro Mizushima, Kazunori Yamada, Masakazu Yamagishi, Mitsuhiro Kawano
OBJECTIVES: The purpose of our study was to define the clinical characteristics of anti-centromere antibody and anti-SS-A/Ro antibody (ACA/SS-A) double positive Sjögren's syndrome (SS) and to clarify the clinical impact of these antibodies. METHODS: We examined 108 patients (6 males, mean age 57.9 years) with SS who underwent labial salivary gland biopsy. The patients were divided into four groups by ACA and anti-SS-A/Ro antibody positivity. Symptoms, laboratory and pathological data, and scleroderma-related data were compared among the groups...
January 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29242559/a-functional-variant-in-the-oas1-gene-is-associated-with-sj%C3%A3-gren-s-syndrome-complicated-with-hbv-infection
#20
Xianjun Liu, Hongcun Xing, Wenjing Gao, Di Yu, Yuming Zhao, Xiaoju Shi, Kun Zhang, Pingya Li, Jiaao Yu, Wei Xu, Hongli Shan, Kaiyu Zhang, Wanguo Bao, Xueqi Fu, Sirui Yang, Shafeng Wang
Hepatitis B virus (HBV) has been suspected to contribute to several autoimmune diseases, including Sjögren's syndrome (SS), although the exact mechanism is unknown. The 2'-5' oligoadenylate synthetase (OAS1) is one of the most important components of the immune system and has significant antiviral functions. We studied a polymorphism rs10774671 of OAS1 gene in Han Chinese descent. The minor allele G was significantly associated with a decreased risk for SS, anti-SSA-positive SS, and anti-SSA-positive SS complicated with HBV infection, which have not been seen in anti-SSA-negative SS and HBcAb-negative SS patients...
December 14, 2017: Scientific Reports
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