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https://www.readbyqxmd.com/read/29667938/suggested-design-of-gold-nanoobjects-based-terahertz-radiation-source-for-biomedical-research
#1
Andrei Postnikov, Kamil Moldosanov
Gold nanoparticles (GNPs) may serve as "devices" to emit electromagnetic radiation in the terahertz (THz) range, whereby the energy is delivered by radio frequency or microwave photons which won't by themselves induce transitions between sparse confinement-shaped electron levels of a GNP, but may borrow the energy from longitudinal acoustic phonons to overcome the confinement gap. Upon excitation, the Fermi electron cannot relax otherwise than via emitting a THz photon, the other relaxation channels being blocked by force of shape and size considerations...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667829/highly-selective-pd-catalyzed-direct-c-f-bond-arylation-of-polyfluoroarenes
#2
Zhi-Ji Luo, Hai-Yang Zhao, Xingang Zhang
A directing-group-free palladium-catalyzed direct arylation of simple polyfluoroarenes with arylboronic acids through selective C-F bond activation is described. The combination of Pd(OAc)2 with BrettPhos was identified as an efficient catalytic system to promote the reaction with high regioselectivity and broad substrate scope. Preliminary mechanistic studies reveal that the oxidative addition of Pd to the C-F bond is involved in the catalytic cycle.
April 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29667684/interaction-of-na-k-mg-2-and-ca-2-counter-cations-with-rna
#3
REVIEW
Stefan K Kolev, Petko St Petkov, Miroslav A Rangelov, Dimitar V Trifonov, Teodor I Milenov, Georgi N Vayssilov
Alkaline and alkaline earth ions, namely Na+, K+, Mg2+ and Ca2+, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29667683/nfsi-participated-intermolecular-aminoazidation-of-alkene-through-iron-catalysis
#4
Bowen Lei, Xiaojiao Wang, Lifang Ma, Yan Li, Ziyuan Li
An iron-catalysed intermolecular vicinal aminoazidation of alkenes, using N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl azide (TMSN3) as the imidating and azidating reagents, respectively, is described, which could potentially provide a valuable route toward diverse vicinal diamine derivatives of great significance in medicinal chemistry and organic synthesis. Such iron-catalysed aminative bisfunctionalization of alkenes with NFSI has not been reported yet. Comparing to previously employed copper or palladium catalysts, the iron catalyst, FeCl2, was demonstrated to be a good alternative for its comparable efficiency and broad alkene scope...
April 18, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29667618/remember-interventional-eus-is-performed-using-an-elevator-containing-scope-as-well
#5
EDITORIAL
Siyu Sun, Caixia Wang, Sheng Wang
No abstract text is available yet for this article.
March 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29667331/divergent-synthesis-of-cf3-substituted-allenyl-nitriles-by-ligand-controlled-radical-1-2-and-1-4-addition-of-1-3-enynes
#6
Guosheng Liu, Fei Wang, Dinghai Wang, Ling Liang, Ronghua Lu, Pinhong Chen, Zhenyang Lin, Yu Zhou
A ligand-controlled system that enables regioselective trifluoromethylcyanation of 1,3-enynes has been identified, which provides an access to a variety of CF3-containing tri- and tetra-substituted allenyl nitriles. We disclose that the involved propargylic radicals can be selectively trapped by (Box)Cu(II) cyanide, while the tautomerized allenyl radicals are trapped by (phen)Cu(II) cyanide. In addition, the reaction features broad substrate scope and excellent functional group compatibility. Moreover, this protocol represents a novel regioselectivity-tunable functionalization of 1,3-enynes via radicals, which we believe will have great potential implications for the development of catalytic systems for selectivity control in radical and organometallic chemistry...
April 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29667145/ethical-challenges-faced-by-healthcare-professionals-who-care-for-suicidal-patients-a-scoping-review
#7
Victoria Saigle, Eric Racine
For each one of the approximately 800,000 people who die from suicide every year, an additional twenty people attempt suicide. Many of these attempts result in hospitalization or in contact with other healthcare services. However, many personal, educational, and institutional barriers make it difficult for healthcare professionals to care for suicidal individuals. We reviewed literature that discusses suicidal patients in healthcare settings in order to highlight common ethical issues and to identify knowledge gaps...
April 17, 2018: Monash Bioethics Review
https://www.readbyqxmd.com/read/29667091/clinical-impact-of-the-intra-scope-channel-stent-release-technique-in-preventing-stent-migration-during-eus-guided-hepaticogastrostomy
#8
Akira Miyano, Takeshi Ogura, Kazuhiro Yamamoto, Atsushi Okuda, Nobu Nishioka, Kazuhide Higuchi
BACKGROUNDS: Stent migration following endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS) may sometimes be fatal because there are no adhesions between the biliary tract and stomach. To prevent stent migration and minimize the stent length in the abdominal cavity, we recently performed EUS-HGS using the technique of releasing the stent within the scope channel. AIMS: To examine the technical feasibility of the intra-scope channel stent release technique...
April 17, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29666678/allergic-rhinitis-in-relation-to-food-allergies-pointers-to-future-research
#9
Rashid Al-Abri, Asdaf S Al-Amri, Zaina Al-Dhahli, Ajoy M Varghese
Allergic rhinitis is a ubiquitous type of allergic reaction which results in significant costs to affected patients and their families. Although allergic rhinitis can coexist with other atopic conditions, the role of food allergies in the development of allergic rhinitis has not been well studied. This article explores relevant literature on this subject in order to identify gaps in the available body of knowledge and elucidate scope for further research.
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666451/exploring-the-extent-and-scope-of-epigenetic-inheritance
#10
REVIEW
Elizabeth J Radford
Environmental factors, particularly during early life, are important for the later metabolic health of the individual. In our obesogenic environment, it is of major socio-economic importance to investigate the mechanisms that contribute to the risk of metabolic ill health. Increasing evidence from a variety of model organisms suggests that non-genetically determined phenotypes, including metabolic effects such as glucose intolerance and obesity, can be passed between generations, which encourages us to revisit heredity...
April 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29666322/genetic-control-of-yellow-vein-mosaic-virus-disease-tolerance-in-abelmoschus-esculentus-l-moench
#11
Pushparani Senjam, Bijoy Kumar Senapati, Arup Chattopadhyay, Subrata Dutta
Okra's (Abelmoschus esculentus (L.) Moench) commercial cultivation is threatened in the tropics due to high incidence of yellow vein mosaic virus (YVMV) disease. Okra geneticists across the world tried to understand the inheritance pattern of YVMV disease tolerance without much success. Therefore, the inheritance pattern of YVMV disease in okra was revisited by employing sixgenerations (P₁, P₂, F₁, F₂, BC₁ and BC₂) of four selected crosses (one tolerant × tolerant, two tolerant × susceptible and one susceptible × susceptible) using two tolerant (BCO-1 and Lal Bhendi) and two susceptible (Japanese Jhar Bhendi and PAN 2127) genotypes...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666129/preventing-emergency-department-ed-visits-and-hospitalisations-of-older-adults-with-cognitive-impairment-compared-with-the-general-senior-population-what-do-we-know-about-avoidable-incidents-results-from-a-scoping-review
#12
Mireille Gagnon-Roy, Benyahia Hami, Mélissa Généreux, Nathalie Veillette, Marie-Josée Sirois, Mary Egan, Véronique Provencher
OBJECTIVES: Older cognitively impaired adults present a higher risk of hospitalisation and mortality following a visit to the emergency department (ED). Better understanding of avoidable incidents is needed to prevent them and the associated ED presentations in community-dwelling adults. This study aimed to synthetise the actual knowledge concerning these incidents leading this population to ED presentation, as well as possible preventive measures to reduce them. DESIGN: A scoping review was performed according to the Arksey and O'Malley framework...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666018/a-bayesian-evidence-synthesis-approach-to-estimate-disease-prevalence-in-hard-to-reach-populations-hepatitis-c-in-new-york-city
#13
Sarah Tan, Susanna Makela, Daliah Heller, Kevin Konty, Sharon Balter, Tian Zheng, James H Stark
Existing methods to estimate the prevalence of chronic hepatitis C (HCV) in New York City (NYC) are limited in scope and fail to assess hard-to-reach subpopulations with highest risk such as injecting drug users (IDUs). To address these limitations, we employ a Bayesian multi-parameter evidence synthesis model to systematically combine multiple sources of data, account for bias in certain data sources, and provide unbiased HCV prevalence estimates with associated uncertainty. Our approach improves on previous estimates by explicitly accounting for injecting drug use and including data from high-risk subpopulations such as the incarcerated, and is more inclusive, utilizing ten NYC data sources...
February 3, 2018: Epidemics
https://www.readbyqxmd.com/read/29665821/plasma-proteomic-analysis-reveals-altered-protein-abundances-in-cardiovascular-disease
#14
Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Antonia Vlahou
BACKGROUND: Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To this end, we performed a comprehensive proteomic analysis of blood plasma, with the scope to identify disease-associated changes after placing them in the context of existing knowledge, and generate a well characterized dataset for further use in CVD multi-omics integrative analysis...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29665703/culturally-safe-health-initiatives-for-indigenous-peoples-in-canada-a-scoping-review
#15
Lauren Brooks-Cleator, Breanna Phillipps, Audrey Giles
Background Cultural safety has the potential to improve the health disparities between Indigenous and non-Indigenous Canadians, yet practical applications of the concept are lacking in the literature. Purpose This study aims to identify the key components of culturally safe health initiatives for the Indigenous population of Canada to refine its application in health-care settings. Methods We conducted a scoping review of the literature pertaining to culturally safe health promotion programs, initiatives, services, or care for the Indigenous population in Canada...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29665695/women-in-rural-family-medicine-a-qualitative-exploration-of-practice-attributes-that-promote-physician-satisfaction
#16
Carol Hustedde, Heather Paladine, Andrea Wendling, Rupa Prasad, Orlando Sola, Sarah Bjorkman, Julie Phillips
INTRODUCTION: The USA needs more rural physicians. Although women represent half of all US trained medical students, the rural physician workforce has remained predominantly male. Insight is needed into what makes rural practice attractive for women and which practice characteristics allow women physicians to practice successfully in rural areas. This study's purpose was to examine aspects of the practice environment that impact women physicians' professional satisfaction and commitment to rural medicine...
April 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29665632/metal-stent-placement-in-the-afferent-loop-obstructed-by-peritoneal-metastases-experience-of-five-cases
#17
Yoshihide Kanno, Tetsuya Ohira, Yoshihiro Harada, Yoshiki Koike, Taku Yamagata, Megumi Tanaka, Tomohiro Shimada, Kei Ito
Afferent loop syndrome is often difficult to resolve. Among patients with afferent loop syndrome whose data were extracted from databases, 5 patients in whom metal stent placement was attempted were included and evaluated in this study. The procedure was technically successful without any adverse events in all patients. Metal stent(s) was placed with an endoscope in the through-the-scope manner in 4 patients and via a percutaneous route in 1 patient. Obvious clinical efficacy was observed in all patients. Adverse events related to the procedure and stent occlusion during the follow-up period were not observed...
April 18, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29665279/rh-iii-catalyzed-direct-c8-arylation-of-quinoline-n-oxides-using-diazonaphthalen-2-1h-ones-a-practical-approach-towards-8-azabinol
#18
Bidhan Ghosh, Aniruddha Biswas, Soumen Chakraborty, Rajarshi Samanta
An efficient Rh(III)-catalyzed redox-neutral method for the direct C8- arylation of quinoline N-oxides using diazonaphthalen-2(1H)-one as coupling partner has been demonstrated. The developed method is simple, scalable and straightforward with wide range of substrate scope. The applicative potential was extended with late-stage functionalization and straightforward synthesis of 8-azaBINOL derivative. A plausible reaction pathway was proposed after carrying out preliminary control studies.
April 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29665035/challenges-of-comprehensive-taxon-sampling-in-comparative-biology-wrestling-with-rosids
#19
Ryan A Folk, Miao Sun, Pamela S Soltis, Stephen A Smith, Douglas E Soltis, Robert P Guralnick
Using phylogenetic approaches to test hypotheses on a large scale, in terms of both species sampling and associated species traits and occurrence data-and doing this with rigor despite all the attendant challenges-is critical for addressing many broad questions in evolution and ecology. However, application of such approaches to empirical systems is hampered by a lingering series of theoretical and practical bottlenecks. The community is still wrestling with the challenges of how to develop species-level, comprehensively sampled phylogenies and associated geographic and phenotypic resources that enable global-scale analyses...
April 17, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29664648/cis-selective-decarboxylative-alkenylation-of-aliphatic-carboxylic-acids-with-vinyl-arenes-enabled-by-photoredox-palladium-uphill-triple-catalysis
#20
Chao Zheng, Wan-Min Cheng, Hong-Lian Li, Ri-Song Na, Rui Shang
An iridium photoredox catalyst in combination with phenanthroline-supported palladium catalyst catalyzes decarboxylative alkenylation of tertiary and secondary aliphatic carboxylic acids with vinyl arenes to deliver β-alkylated styrenes with Z-selectivity. A broad scope of aliphatic carboxylic acids, including amino acids, exhibit as amenable substrates, and external oxidant is not required. The reaction proceeds by synergistic utilization of both energy-transfer and electron-transfer reactivity of iridium photoredox catalyst merging with palladium-catalyzed hydride elimination and insertion...
April 17, 2018: Organic Letters
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