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https://www.readbyqxmd.com/read/29471338/transitioning-from-river-blindness-control-to-elimination-steps-toward-stopping-treatment
#1
Paul T Cantey, Sharon L Roy, Daniel Boakye, Upendo Mwingira, Eric A Ottesen, Adrian D Hopkins, Yao K Sodahlon
The transition from onchocerciasis control to elimination requires country programmes to rethink their approach to a variety of activities as they move from addressing morbidity to addressing transmission of the parasite. Although the 2016 WHO guidelines provide extensive recommendations, it was beyond the scope of the document to provide guidance on all aspects of the transition. This paper will discuss some of the important issues that programmes are grappling with as they transition to elimination and provide some potential approaches that programmes can use to address them...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29470823/methodological-characteristics-and-future-directions-for-plyometric-jump-training-research-a-scoping-review
#2
REVIEW
Rodrigo Ramirez-Campillo, Cristian Álvarez, Antonio García-Hermoso, Robinson Ramírez-Vélez, Paulo Gentil, Abbas Asadi, Helmi Chaabene, Jason Moran, Cesar Meylan, Antonio García-de-Alcaraz, Javier Sanchez-Sanchez, Fabio Y Nakamura, Urs Granacher, William Kraemer, Mikel Izquierdo
Recently, there has been a proliferation of published articles on the effect of plyometric jump training, including several review articles and meta-analyses. However, these types of research articles are generally of narrow scope. Furthermore, methodological limitations among studies (e.g., a lack of active/passive control groups) prevent the generalization of results, and these factors need to be addressed by researchers. On that basis, the aims of this scoping review were to (1) characterize the main elements of plyometric jump training studies (e...
February 22, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29470759/problem-gambling-and-delinquent-behaviours-among-adolescents-a-scoping-review
#3
David T Kryszajtys, Tara E Hahmann, Andrée Schuler, Sarah Hamilton-Wright, Carolyn P Ziegler, Flora I Matheson
Despite many studies indicating an association between problem gambling and delinquent behaviours among adolescents, there has been no effort to systematically analyze the state of the literature on this relationship. To fill this gap, we conducted a scoping review of the literature published between 2000 and 2016 on problem gambling and delinquent behaviours among adolescents. We searched twelve databases and reviewed reference lists to identify eligible studies. Search terms included a combination of medical subject headings and keywords for gambling, youth, and delinquency, which were combined with the Boolean operator "AND"...
February 22, 2018: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29470710/risk-stratification-genomic-data-and-the-law
#4
REVIEW
Alison Hall, Thomas Finnegan, Susmita Chowdhury, Tom Dent, Mark Kroese, Hilary Burton
Risk prediction models have a key role in stratified disease prevention, and the incorporation of genomic data into these models promises more effective personalisation. Although the clinical utility of incorporating genomic data into risk prediction tools is increasingly compelling, at least for some applications and disease types, the legal and regulatory implications have not been examined and have been overshadowed by discussions about clinical and scientific utility and feasibility. We held a workshop to explore relevant legal and regulatory perspectives from four EU Member States: France, Germany, the Netherlands and the UK...
February 22, 2018: Journal of Community Genetics
https://www.readbyqxmd.com/read/29470574/changes-in-scope-of-procedures-performed-by-pediatric-otolaryngologists-in-the-past-decade
#5
Alexandria L Irace, Catherine Shank, Eelam A Adil, Michael J Cunningham, Kosuke Kawai, Georgios Sideridis, Reza Rahbar
Importance: Monitoring current trends in pediatric otolaryngology will help adjust our training and practice paradigms in a way that ensures the long-term viability of the specialty. Objectives: To gauge the current scope of pediatric otolaryngology (ORL) practice within and outside of the United States and to identify changes in caseload over the past decade. Design, Setting, and Participants: An online survey was sent to pediatric ORL chairs and/or fellowship directors at 42 institutions in the United States and abroad...
February 22, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29470517/two-essential-thioredoxins-mediate-apicoplast-biogenesis-protein-import-and-gene-expression-in-toxoplasma-gondii
#6
Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner
Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various redox regulators. The apicoplast, an essential plastid organelle, is a verified apicomplexan drug target. Nuclear-encoded apicoplast proteins traffic through the ER and multiple apicoplast sub-compartments to their place of function. We propose that thioredoxins contribute to the control of protein trafficking and of protein function within these apicoplast compartments...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29470507/vehicle-development-pharmacokinetics-and-toxicity-of-the-anti-invasive-agent-4-fluoro-3-4-5-trimethoxychalcone-in-rodents
#7
Liselot M Mus, Geertrui Denecker, Frank Speleman, Bart I Roman
Effective inhibitors of invasion and metastasis represent a serious unmet clinical need. We have recently identified 4-fluoro-3',4',5'-trimethoxychalcone or C16 as a potent anti-invasive molecule. In this paper, we report on the development of an optimized vehicle for oral administration of C16. We also explore its pharmacokinetic and toxicity profile in rodents as a prelude to a broad-scope evaluation as a pharmacological tool in animal models of disease. C16 showed suboptimal pharmacokinetics with limited oral bioavailability and whole blood stability...
2018: PloS One
https://www.readbyqxmd.com/read/29470405/gentamicin-releasing-mesoporous-zno-structures
#8
Marco Laurenti, Valentina Cauda
Among metal oxides, zinc oxide (ZnO) is one of the most attractive materials thanks to its biocompatible and biodegradable properties along with the existence of various morphologies featuring piezoelectric, semiconducting and photocatalytic activities. All of these structures were successfully prepared and tested for numerous applications, including optoelectronics, sensors and biomedical ones. In the last case, biocompatible ZnO nanomaterials positively influenced cells growth and tissue regeneration as well, promoting wound healing and new bone formation...
February 22, 2018: Materials
https://www.readbyqxmd.com/read/29470218/expanding-rn-scope-of-practice-to-include-lumbar-puncture
#9
Jennifer Ernst, Christine D Aliory, Catherine R Yows
: The competing demands of caring for high-acuity patients, reducing health care costs, and improving access to specialty care are complex challenges facing all health care providers. One approach-empowering nurses to expand their scope of practice-has been successfully employed for two decades by the nurse and physician leadership of a neurology department in an urban academic medical center. This article discusses the department's implementation of a quality improvement initiative to enhance access to neurology services in an ambulatory clinic by extending nursing practice to include lumbar puncture...
March 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29469148/advances-in-point-of-care-diagnostic-devices-in-cancers
#10
Puja Sandbhor Gaikwad, Rinti Banerjee
The early diagnosis and monitoring of the progress of cancers are limited due to the lack of adequate screening tools. Ultrasensitive and precise point-of-care cancer diagnostic tools are required for the early detection and screening of cancer biomarkers at the bedside with accuracy and specificity of diagnosis. Recent advances in nano- and microfabrication based technologies integrated with different sensing platforms are accelerating the development of rapid, low-cost and reliable point-of-care cancer diagnostic devices...
February 22, 2018: Analyst
https://www.readbyqxmd.com/read/29469096/palladium-catalysed-electrophilic-aromatic-c-h-fluorination
#11
Kumiko Yamamoto, Jiakun Li, Jeffrey A O Garber, Julian D Rolfes, Gregory B Boursalian, Jannik C Borghs, Christophe Genicot, Jérôme Jacq, Maurice van Gastel, Frank Neese, Tobias Ritter
Aryl fluorides are widely used in the pharmaceutical and agrochemical industries, and recent advances have enabled their synthesis through the conversion of various functional groups. However, there is a lack of general methods for direct aromatic carbon-hydrogen (C-H) fluorination. Conventional methods require the use of either strong fluorinating reagents, which are often unselective and difficult to handle, such as elemental fluorine, or less reactive reagents that attack only the most activated arenes, which reduces the substrate scope...
February 21, 2018: Nature
https://www.readbyqxmd.com/read/29468810/cellular-localization-and-biological-effects-of-20nm-gold-nanoparticles
#12
Gamze Tan, Mehmet Ali Onur
Gold nanoparticles (AuNPs) have recently emerged as prominent vehicles for many biomedical applications from sensing to delivery. The relevant literature contains conflicting data about the effects of AuNPs on living cells. The aim of present study is the synthesis and characterization of AuNPs at nanoscale, tracking their cellular localization and determining their effects on cell viability, migration and angiogenesis. Within this scope, 19-20 nm AuNPs were synthesized and characterized using various spectrometric techniques to determine their size, shape and surface properties such as charge and texture...
February 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29468553/crispr-cas9-mediated-knockout-of-rb1-in-xenopus-tropicalis
#13
Thomas Naert, Kris Vleminckx
At this time, no molecular targeted therapies exist for treatment of retinoblastoma. This can be, in part, attributed to the lack of animal models that allow for both rapid identification of novel therapeutic targets and hypothesis driven drug testing. Within this scope, we have recently reported the first genuine genetic nonmammalian retinoblastoma cancer model within the aquatic model organism Xenopus tropicalis (Naert et al., Sci Rep 6: 35263, 2016). Here we describe the methods to generate rb1 mosaic mutant Xenopus tropicalis by employing the CRISPR/Cas9 technology...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468518/cultural-factors-influencing-osteoarthritis-care-in-asian-communities-a-review-of-the-evidence
#14
REVIEW
Thrmiga Sathiyamoorthy, Shabana Amanda Ali, Marita Kloseck
With the prevalence of osteoarthritis (OA) increasing internationally, there is a need to study the impact of this disease on culturally diverse populations. Individuals of Asian descent make up more than 60% of the world population, yet comprehensive information on the cultural factors that impact OA care is not available. Scoping review methodology using directed content analysis was employed to identify and analyze existing research on OA care for Asians. A categorization matrix was developed using the six care areas from the OA clinical practice guidelines along with an additional three non-clinical areas (cross-cultural adaptation of clinical tools; psychological well-being; family systems and informal care) identified in an initial scan resulting in a total of nine OA care areas to guide initial coding...
February 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29467968/continuity-of-care-in-resident-outpatient-clinics-a-scoping-review-of-the-literature
#15
REVIEW
Jeremey Walker, Brittany Payne, B Lee Clemans-Taylor, Erin Dunn Snyder
Background : Continuity between patients and physicians is a core principle of primary care and an accreditation requirement. Resident continuity clinics face challenges in nurturing continuity for their patients and trainees. Objective : We undertook a scoping review of the literature to better understand published benchmarks for resident continuity; the effectiveness of interventions to improve continuity; and the impact of continuity on resident and patient satisfaction, patient outcomes, and resident career choice...
February 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29467606/integrating-brain-and-biomechanical-models-a-new-paradigm-for-understanding-neuro-muscular-control
#16
Sebastian S James, Chris Papapavlou, Alexander Blenkinsop, Alexander J Cope, Sean R Anderson, Konstantinos Moustakas, Kevin N Gurney
To date, realistic models of how the central nervous system governs behavior have been restricted in scope to the brain, brainstem or spinal column, as if these existed as disembodied organs. Further, the model is often exercised in relation to an in vivo physiological experiment with input comprising an impulse, a periodic signal or constant activation, and output as a pattern of neural activity in one or more neural populations. Any link to behavior is inferred only indirectly via these activity patterns...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29467291/epigenetic-alterations-in-longevity-regulators-reduced-life-span-and-exacerbated-aging-related-pathology-in-old-father-offspring-mice
#17
Kan Xie, Devon P Ryan, Brandon L Pearson, Kristin S Henzel, Frauke Neff, Ramon O Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H Busch, Gerhard Ehninger, Anna Matynia, Walker S Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger
Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next generation. In humans, advanced paternal age has been associated with increased risk for a number of diseases. Experiments in rodent models have provided initial evidence that paternal age can influence behavioral traits in offspring animals, but the overall scope and extent of paternal age effects on health and disease across the life span remain underexplored...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29467019/clinical-and-cost-effectiveness-of-the-star-care-pathway-compared-to-usual-care-for-patients-with-chronic-pain-after-total-knee-replacement-study-protocol-for-a-uk-randomised-controlled-trial
#18
Vikki Wylde, Wendy Bertram, Andrew D Beswick, Ashley W Blom, Julie Bruce, Amanda Burston, Jane Dennis, Kirsty Garfield, Nicholas Howells, Athene Lane, Candy McCabe, Andrew J Moore, Sian Noble, Tim J Peters, Andrew Price, Emily Sanderson, Andrew D Toms, David A Walsh, Simon White, Rachael Gooberman-Hill
BACKGROUND: Approximately 20% of patients experience chronic pain after total knee replacement. There is little evidence for effective interventions for the management of this pain, and current healthcare provision is patchy and inconsistent. Given the complexity of this condition, multimodal and individualised interventions matched to pain characteristics are needed. We have undertaken a comprehensive programme of work to develop a care pathway for patients with chronic pain after total knee replacement...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29466761/nkp46-receptor-mediated-interferon-%C3%AE-production-by-natural-killer-cells-increases-fibronectin-1-to-alter-tumor-architecture-and-control-metastasis
#19
Ariella Glasner, Assi Levi, Jonatan Enk, Batya Isaacson, Sergey Viukov, Shari Orlanski, Alon Scope, Tzahi Neuman, Claes D Enk, Jacob H Hanna, Veronika Sexl, Stipan Jonjic, Barbara Seliger, Laurence Zitvogel, Ofer Mandelboim
No abstract text is available yet for this article.
February 20, 2018: Immunity
https://www.readbyqxmd.com/read/29466649/preclinical-efficacy-against-toxic-activities-of-medically-relevant-bothrops-sp-serpentes-viperidae-snake-venoms-by-a-polyspecific-antivenom-produced-in-mexico
#20
Álvaro Segura, María Herrera, Mariángela Vargas, Mauren Villalta, Alfredo Uscanga-Reynell, Guillermo León, José María Gutiérrez
The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenating and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica)...
March 2017: Revista de Biología Tropical
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