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Mohua Das, Yang Tianming, Dong Jinghua, Fransisca Prasetya, Xie Yiming, Kendra Wong, Adeline Cheong, Esther C Y Woon
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically-templated DCC employ only a single biomolecule in directing the self-assembly process. To expand the scope and potential of DCC, herein, we developed a novel multi-protein DCC strategy which combines the discriminatory power of zwitterionic 'thermal-tag' with the sensitivity of differential scanning fluorimetry. This strategy enables the discovery of ligands against several proteins of interest concurrently...
June 19, 2018: Chemistry, An Asian Journal
Krzysztof A Zacharski, Mark Southern, Alan Ryan, Catherine C Adley
Microbiological hazards can occur when foodstuffs come into contact with contaminated surfaces or infectious agents dispersed by air currents in the manufacturing environment. An environmental monitoring program (EMP) is a critical aspect of sustainable and safe food manufacturing used to evaluate the effectiveness of the microbial controls in place. An effective EMP should be based on risk analysis, taking into account previous sampling history to determine the selection of the sampling points, the scope of the test, and the frequency of analysis...
June 19, 2018: Journal of Food Protection
Vidyasagar Maurya, Chandrakumar Appayee
The first catalytic approach for the asymmetric synthesis of 3,4-disubstituted cyclohexadiene carbaldehydes through an inverse-electron-demand Diels-Alder reaction is described. A variety of arylacetaldehydes and α,β,γ,δ-unsaturated aldehydes are tested under the mild reaction conditions catalyzed by l-proline to obtain the trans diastereomeric products with good yields and high enantioselectivities. The scope of this methodology is further extended to the asymmetric synthesis 3,4-disubstituted cyclohexane carbaldehydes and their derivatives...
June 19, 2018: Organic Letters
Tomoaki Tashima, Kouichi Nonaka, Shomei Ryozawa, Koji Nagata
No abstract text is available yet for this article.
March 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Paola Soriani, Carmelo Barbera, Vincenzo Giorgio Mirante, Lucia Miglioli, Mauro Manno
No abstract text is available yet for this article.
March 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Ravishankar Asokkumar, Andres Sanchez-Yague, Roy Soetikno
No abstract text is available yet for this article.
May 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Ann E Fronczek, Nicole A Rouhana
Access to essential health-promoting nursing care is increasingly facilitated through the expanding scope and capabilities provided through the utilization of telehealth technologies. Telehealth technologies facilitate the nursing process with clients at a distance in multiple ways, such as video conferencing, video conferencing with peripheral diagnostic tools, and store and forward modalities. Nursing care needs to remain the focus of care, but technology is a useful ancillary tool to help clients achieve health outcomes...
July 2018: Nursing Science Quarterly
Tara Mantler, Kimberley T Jackson, Edmund J Walsh
Women who have experienced intimate partner violence (IPV) have significant detrimental physical and mental health consequences associated with the violence as well as numerous barriers to health-care and social service utilization. Service integration offers a solution to help support women who have experienced violence overcome negative health consequences as well as barriers to system navigation and use. The purpose of this scoping review was to examine research activity pertaining to IPV and primary health-care and women's shelters integration...
January 1, 2018: Trauma, Violence & Abuse
Jordi Mestre, Anton Lishchynskyi, Sergio Castillón, Omar Boutureira
We herein present a flexible approach for the introduction of CF3 units into a predefined site of electron-rich alkenes that exploits the regiocontrolled introduction of an iodine handle and subsequent trifluoromethylation of the C(sp2 )-I bond using fluoroform-derived "ligandless" CuCF3 . The broad substrate scope and functional group tolerance together with the scalability and purity of the resulting products enabled the controlled, late-stage synthesis of single regioisomers of complex CF3 -scaffolds such as sugars, nucleosides (antivirals), and heterocycles (indoles, chromones) with potential for academic and industrial applications...
June 19, 2018: Journal of Organic Chemistry
Konika Sharma, Karn Wijarnpreecha, Nancy Merrell
Diphyllobothrium latum ( D. latum ) infection in humans is uncommon in the United States. Although there has been a drastic decline in the report of D. latum infection in this region, physicians should be aware of an uncommon presentation and its clinical relevance. We report a case of 55-year-old female of Ecuadorian/Peruvian origin who presented with an unknown cause of chronic right lower quadrant abdominal pain for 2 months without other particular symptoms. Initial workup revealed evidence of iron deficiency anemia, and stool occult blood test was positive...
June 2018: Gastroenterology Research
Jean-David Morel, Anja O Paatero, Jiajie Wei, Jonathan W Yewdell, Laure Guenin-Macé, Delphi Van Haver, Francis Impens, Natalia Pietrosemoli, Ville O Paavilainen, Caroline Demangel
Mycolactone is a bacteria-derived macrolide that blocks the biogenesis of a large array of secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 blockade in living cells. In T lymphocytes, dendritic cells and sensory neurons, Sec61 substrates downregulated by mycolactone were in order of incidence: secretory proteins (with a signal peptide but no transmembrane domain), TMPs with a signal peptide (Type I) and TMPs without signal peptide and a cytosolic N-terminus (Type II)...
June 18, 2018: Molecular & Cellular Proteomics: MCP
Chanel F Whittaker, Margaret A Miklich, Roshni S Patel, Jeffrey C Fink
Ensuring patient safety is a priority of medical care because iatrogenic injury has been a primary concern. Medications are an important source of medical errors, and kidney disease is a thoroughfare of factors threatening safe administration of medicines. Principal among these is reduced kidney function because almost half of all medications used are eliminated via the kidney. Additionally, kidney patients often suffer from multimorbidity, including diabetes, hypertension, and heart failure, with a range of prescribers who often do not coordinate treatments...
June 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Tamsyn M Uren Webster, Sofia Consuegra, Matthew Hitchings, Carlos Garcia de Leaniz
The microbiome has a crucial influence on host phenotype, and is of broad interest to ecological and evolutionary research. Yet, the extent of variation that occurs in the microbiome within and between populations is unclear. We characterised the skin and gut microbiome of seven populations of juvenile Atlantic salmon ( Salmo salar ) inhabiting a diverse range of environments, including hatchery-reared and wild populations. We found shared skin OTUs across all populations and core gut microbiota for all wild fish, but the diversity and structure of both skin and gut microbial communities were distinct between populations...
June 18, 2018: Applied and Environmental Microbiology
Aaron J Fisher, John D Medaglia, Bertus F Jeronimus
Only for ergodic processes will inferences based on group-level data generalize to individual experience or behavior. Because human social and psychological processes typically have an individually variable and time-varying nature, they are unlikely to be ergodic. In this paper, six studies with a repeated-measure design were used for symmetric comparisons of interindividual and intraindividual variation. Our results delineate the potential scope and impact of nonergodic data in human subjects research. Analyses across six samples (with 87-94 participants and an equal number of assessments per participant) showed some degree of agreement in central tendency estimates (mean) between groups and individuals across constructs and data collection paradigms...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Marta Ghio, Karolin Haegert, Matilde M Vaghi, Marco Tettamanti
We rarely use abstract and concrete concepts in isolation but rather embedded within a linguistic context. To examine the modulatory impact of the linguistic context on conceptual processing, we isolated the case of sentential negation polarity, in which an interaction occurs between the syntactic operator not and conceptual information in the negation's scope. Previous studies suggested that sentential negation of concrete action-related concepts modulates activation in the fronto-parieto-temporal action representation network...
August 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Evi Germeni, Julia Frost, Ruth Garside, Morwenna Rogers, Jose M Valderas, Nicky Britten
BACKGROUND: Reducing unnecessary prescribing remains a key priority for tackling the global rise of antibiotic-resistant infections. AIM: The authors sought to update a 2011 qualitative synthesis of GPs' experiences of antibiotic prescribing for acute respiratory tract infections (ARTIs), including their views of interventions aimed at more prudent prescribing. They expanded the original scope to encompass all primary care professionals (PCPs) who can prescribe or dispense antibiotics for ARTIs (for example, nurses and pharmacists)...
June 18, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Patricia Hewston, Nandini Deshpande
Type 2 diabetes mellitus is highly prevalent in older adults (≥65 years of age) and increases fall risk. Fear of falling and low balance confidence are reported in both fallers and nonfallers and can potentially be more debilitating than a fall itself. Therefore, the objective of this scoping review was to examine and map the current research evidence of balance confidence and fear of falling in older adults with type 2 diabetes. A search of CINAHL, EMBASE and PubMed was conducted. The search included MeSH terms and the key terms diabet* AND fear OR falls AND self-efficacy OR balance confidence...
March 6, 2018: Canadian Journal of Diabetes
Olufemi Ajumobi, Perpetua Uhomoibhi, Pamela Onyiah, Obafemi Babalola, Salami Sharafadeen, Maduka D Ughasoro, Al-Mukhtar Y Adamu, Oluwaseun Odeyinka, Taiwo Orimogunje, Ibrahim Maikore, Emmanuel Shekarau, Akintayo Ogunwale, Rotimi Afolabi, Sylvester Udeh, Akpuh Ndubuisi, Ntiense Umoette, Patrick Nguku, IkeOluwapo O Ajayi
BACKGROUND: Employing malaria operational research (MOR) findings in planning national malaria control programmes is gaining increased attention. The malaria control foci are diverse, resources are limited; therefore, agreeing on priority areas is critical. Hitherto, the process of prioritising MOR questions in Nigeria has been limited to few stakeholders. In support of the National Malaria Elimination Programme's (NMEP) effort at setting a MOR agenda, the Nigeria Field Epidemiology and Laboratory Training Programme (NFELTP) in collaboration with NMEP conducted preliminary exploratory study to identify key malaria research gaps and needs, and provide data to inform setting a robust national MOR agenda...
June 18, 2018: BMC Health Services Research
Emily Hansen, Leigh Tesch, Jennifer Ayton
BACKGROUND: Fathers' attitudes and actions can positively or negatively affect mothers' intentions to breastfeed, breastfeeding duration and exclusivity. In-depth information about fathers' perspectives on breastfeeding are largely absent in the literature about infant feeding. The objective of this research was to investigate how fathers view breastfeeding. METHODS: This mixed method study recruited Tasmanian fathers with children < 24 months of age. Fathers completed a questionnaire and participated in either semi structured one-on-one or group interviews...
June 18, 2018: BMC Pregnancy and Childbirth
Judith Ortiz, Richard Hofler, Angeline Bushy, Yi-Ling Lin, Ahmad Khanijahani, Andrea Bitney
Background: For decades, U.S. rural areas have experienced shortages of primary care providers. Nurse practitioners (NPs) are helping to reduce that shortage. However, NP scope of practice regulations vary from state-to-state ranging from autonomous practice to direct physician oversight. The purpose of this study was to determine if clinical outcomes of older rural adult patients vary by the level of practice autonomy that states grant to NPs. Methods: This cross-sectional study analyzed data from a sample of Rural Health Clinics (RHCs) (n = 503) located in eight Southeastern states...
June 15, 2018: Healthcare (Basel, Switzerland)
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