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Flaccid paralysis

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https://www.readbyqxmd.com/read/28904728/evaluation-of-the-acute-flaccid-paralysis-afp-surveillance-system-gokwe-north-district-zimbabwe-2015-a-descriptive-cross-sectional-study
#1
Annamercy Makoni, Milton Chemhuru, Notion Gombe, Gerald Shambira, Tsitsi Juru, Donewell Bangure, Mufuta Tshimanga
INTRODUCTION: AFP surveillance was adopted globally as a key strategy for monitoring the progress of the polio eradication initiative. Gokwe North district with an estimated 119 655 children <15 years detected 2 cases, 4 cases and 1 case of AFP in 2012, 2013 and 2014 respectively against a target of 5 cases per year. We therefore set out to evaluate the system and find out why it was failing to detect at least 5 cases per year. METHODS: A descriptive cross sectional study was carried out...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904459/clinical-biochemical-characteristics-and-hospital-outcome-of-acute-intermittent-porphyria-patients-a-descriptive-study-from-north-india
#2
Susheel Kumar, Ashish Bhalla, Navneet Sharma, Deba Prasad Dhibar, Savita Kumari, Subhash Varma
INTRODUCTION: Acute intermittent porphyria (AIP) is an inherited metabolic disease characterized by disordered heme biosynthesis. There is no recent study reported from India. MATERIALS AND METHODS: It was a retrospective, observational study. Clinical records of patients of AIP with acute porphyric attacks admitted from April 2008 to December 2016 were analyzed. RESULTS: Fifteen AIP patients constituted of eight females and seven males were analyzed...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28899886/brainstem-encephalitis-and-acute-polyneuropathy-associated-with-hepatitis-e-infection
#3
Omar Jabbar Salim, Amy Davidson, Kathy Li, John Paul Leach, Craig Heath
A 59-year-old man presented with feverish illness. His Glasgow Coma Scale was 15, had reduced visual acuity in the left eye with partial left ptosis and mild left hemiparesis with an extensor left plantar. Over 48 hours, he accrued multiple cranial nerves palsies and progressed to a flaccid paralysis necessitating admission to an intensive care unit.Cerebrospinal fluid (CSF) study showed 20 lymphocytes and raised protein. Viral and bacterial PCRs were negative. Samples for Lyme, blood-borne viruses, syphilis and autoantibodies were also negative...
September 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28899411/non-polio-enteroviruses-in-faeces-of-children-diagnosed-with-acute-flaccid-paralysis-in-nigeria
#4
T O C Faleye, M O Adewumi, M O Japhet, O M David, A O Oluyege, J A Adeniji, O Famurewa
BACKGROUND: The need to investigate the contribution of non-polio enteroviruses to acute flaccid paralysis (AFP) cannot be over emphasized as we move towards a poliovirus free world. Hence, we aim to identify non-polio enteroviruses recovered from the faeces of children diagnosed with AFP in Nigeria. METHODS: Ninety-six isolates, (95 unidentified and one previously confirmed Sabin poliovirus 3) recovered on RD cell culture from the stool of children <15 years old diagnosed with AFP in 2014 were analyzed...
September 12, 2017: Virology Journal
https://www.readbyqxmd.com/read/28899311/australian-national-enterovirus-reference-laboratory-annual-report-2014
#5
Jason Roberts, Linda Hobday, Aishah Ibrahim, Thomas Aitken, Bruce Thorley
Following the World Health Organization (WHO) recommendation, Australia conducts surveillance for cases of acute flaccid paralysis (AFP) in children less than 15 years of age as the main method to monitor its polio-free status. Cases of AFP in children are notified to the Australian Paediatric Surveillance Unit or the Paediatric Active Enhanced Disease Surveillance System and faecal specimens are referred for virological investigation to the National Enterovirus Reference Laboratory. In 2014, no cases of poliomyelitis were reported from clinical surveillance and Australia reported 1...
June 30, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28890753/introducing-an-accountability-framework-for-polio-eradication-in-ethiopia-results-from-the-first-year-of-implementation-2014-2015
#6
Aron Kassahun, Fiona Braka, Kathleen Gallagher, Aregai Wolde Gebriel, Peter Nsubuga, Pierre M'pele-Kilebou
INTRODUCTION: the World Health Organization (WHO), Ethiopia country office, introduced an accountability framework into its Polio Eradication Program in 2014 with the aim of improving the program's performance. Our study aims to evaluate staff performance and key program indicators following the introduction of the accountability framework. METHODS: the impact of the WHO accountability framework was reviewed after its first year of implementation from June 2014 to June 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28890751/analysis-of-acute-flaccid-paralysis-surveillance-in-ethiopia-2005-2015-progress-and-challenges
#7
Ayesheshem Ademe Tegegne, Braka Fiona, Meseret Eshetu Shebeshi, Fasal Teshager Hailemariam, Aron Kassahun Aregay, Berhane Beyene, Eshetu Wassie Asemahgne, Daddi Jima Woyessa, Abyot Bekele Woyessa
INTRODUCTION: Ethiopia joined the global effort to eradicate polio in 1996, and interrupted indigenous wild poliovirus transmission by December 2001. However, the country experienced numerous separate importations during 2003-2013. Sensitive Acute Flaccid (AFP) surveillance is critical to rule out undetected circulation of WPV and VDPVs. METHODS: In this study described, we used a retrospective descriptive study design to characterize the surveillance performance from 2005 to 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28890193/evaluating-cessation-of-the-type-2-oral-polio-vaccine-by-modeling-pre-and-post-cessation-detection-rates
#8
Steve J Kroiss, Michael Famulare, Hil Lyons, Kevin A McCarthy, Laina D Mercer, Guillaume Chabot-Couture
The globally synchronized removal of the attenuated Sabin type 2 strain from the oral polio vaccine (OPV) in April 2016 marked a major change in polio vaccination policy. This change will provide a significant reduction in the burden of vaccine-associated paralytic polio (VAPP), but may increase the risk of circulating vaccine-derived poliovirus (cVDPV2) outbreaks during the transition period. This risk can be monitored by tracking the disappearance of Sabin-like type 2 (SL2) using data from the polio surveillance system...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28886038/diagnoses-infections-and-injuries-in-northern-syrian-children-during-the-civil-war-a-cross-sectional-study
#9
Gerlant van Berlaer, Abdallah Mohamed Elsafti, Mohammad Al Safadi, Saad Souhil Saeed, Ronald Buyl, Michel Debacker, Atef Redwan, Ives Hubloue
BACKGROUND: The civil war in Syria including the deliberate targeting of healthcare services resulted in a complex humanitarian emergency, seriously affecting children's health. The objectives of this study are to document diagnoses and disease categories in Northern Syrian children after four years of conflict, and to document infectious diseases and injuries in this vulnerable population. METHODS: In a prospective cross-sectional observational sample study conducted in May 2015, healthcare workers registered demographics, comorbidities, and diagnoses (categorised according to the International Classification of Diseases version 10) in children visited at home and in internally displaced persons camps in four Syrian governorates...
2017: PloS One
https://www.readbyqxmd.com/read/28879524/uptake-of-clostridial-neurotoxins-into-cells-and-dissemination
#10
Chloé Connan, Michel R Popoff
Clostridial neurotoxins, botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT), are potent toxins, which are responsible for severe neurological diseases in man and animals. BoNTs induce a flaccid paralysis (botulism) by inhibiting acetylcholine release at the neuromuscular junctions, whereas TeNT causes a spastic paralysis (tetanus) by blocking the neurotransmitter release (glycine, GABA) in inhibitory interneurons within the central nervous system. Clostridial neurotoxins recognize specific receptor(s) on the target neuronal cells and enter via a receptor-mediated endocytosis...
September 7, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28877682/epidemiologic-and-clinical-parameters-of-west-nile-virus-infections-in-humans-a-scoping-review
#11
Man Wah Yeung, Emily Shing, Mark Nelder, Beate Sander
BACKGROUND: Clinical syndromes associated with West Nile virus (WNV) infection range from fever to neuroinvasive disease. Understanding WNV epidemiology and disease history is important for guiding patient care and healthcare decision-making. The objective of this review was to characterize the existing body of peer-reviewed and surveillance literature on WNV syndromes and summarize epidemiologic and clinical parameters. METHODS: We followed scoping review methodology described by the Joanna Briggs Institute...
September 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28869493/vaccines-against-botulism
#12
REVIEW
Grace Sundeen, Joseph T Barbieri
Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was used to vaccinate people who are at high risk of contracting botulism. However, this formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was losing potency and was discontinued. This article reviews the different vaccines being developed to replace the discontinued toxoid vaccine...
September 2, 2017: Toxins
https://www.readbyqxmd.com/read/28857219/non-polio-enterovirus-detection-with-acute-flaccid-paralysis-a-systematic-review
#13
Sneha Suresh, Sarah Forgie, Joan Robinson
Acute flaccid paralysis (AFP), as defined by the World Health Organization, is characterized by an acute onset of limb weakness. In the post-polio era, other enterovirus serotypes associated with AFP may become more prominent. This study aims to collate the data on the non-polio enteroviruses (NPEV) associated with AFP. A systematic review of published case reports, case series and surveillance studies of AFP from 1960 through 2017 was undertaken. Data were collected including the country of the study, number of specimens positive for NPEV and available clinical data...
August 31, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28855045/acute-flaccid-myelitis-in-german-children-in-2016-the-return-of-polio
#14
Johannes Hübner, Bernd Kruse, Hans-Jürgen Christen, Jürgen Weidenmann, Viktoria Weiner, Jan-Christoph Schöne-Bake, Anna Eichinger, Sabine Diedrich, Wolfgang Müller-Felber
BACKGROUND: Although poliomyelitis has almost been eradicated worldwide, cases of a polio-like disease with asymmetrical flaccid paralysis of variable severity have been seen repeatedly in recent years. METHODS: Data were collected on children treated in hospitals in the German federal states of Bavaria and Lower Saxony in 2016. The frequency of disease across Germany was estimated on the basis of voluntary reporting to the Robert Koch Institute. 16 cases were registered there for the entire year 2016...
August 21, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28852711/enterovirus-d68-in-viet-nam-2009-2015
#15
Nguyen Thi Han Ny, Nguyen To Anh, Vu Thi Ty Hang, Lam Anh Nguyet, Tran Tan Thanh, Do Quang Ha, Ngo Ngoc Quang Minh, Do Lien Anh Ha, Angela McBride, Ha Manh Tuan, Stephen Baker, Pham Thi Thanh Tam, Tran My Phuc, Dang Thao Huong, Tran Quoc Loi, Nguyen Tran Anh Vu, Nguyen Van Hung, Tran Thi Thuy Minh, Nguyen Van Xang, Nguyen Dong, Ho Dang Trung Nghia, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Catherine Anscombe, Tan Le Van
BACKGROUND: Since 1962, enterovirus D68 (EV-D68) has been implicated in multiple outbreaks and sporadic cases of respiratory infection worldwide, but especially in the USA and Europe with an increasing frequency between 2010 and 2014. We describe the detection, associated clinical features and molecular characterization of EV-D68 in central and southern Viet Nam between 2009 and 2015. METHODS: Enterovirus/rhinovirus PCR positive respiratory or CSF samples taken from children and adults with respiratory/central nervous system infections in Viet Nam were tested by an EV-D68 specific PCR...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28841083/hypokalaemia-periodic-paralysis
#16
Liam J Stapleton
Hypokalaemic periodic paralysis is a rare skeletal muscle channelopathy causing flaccid paralysis, which predominantly presents in adolescents and young adults. I report a case of a 33-year-old Caucasian man who presented with sudden onset paralysis, following previous similar presentations without investigation. Blood tests revealed undetectable serum potassium levels in the context of paralysis. Other causes of hypokalaemia were excluded, and the patient was treated with planned lifelong prophylactic potassium replacement for a diagnosis of primary hypokalaemic periodic paralysis...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28840670/-adult-experience-with-the-tibialis-posterior-transposition-to-the-center-of-the-foot-in-neuromuscular-disease
#17
P Parra-Téllez, H Jiménez-López, E López-Gavito, J Vázquez-Escamilla
The transfer of the posterior tibial tendon to the center of the dorsum of the foot is a method used to achieve dorsiflexion in flaccid paralysis of the anterolateral leg muscles or muscular imbalance of clubfoot. OBJECTIVE: To describe functional results back to the surgical procedure for transposition of posterior tibial the center of the foot. MATERIAL AND METHODS: The study design was observational, descriptive, transversal, ambispective with a description of the world of work patients with impaired dorsiflexora foot muscles and impaired gait in the period January 2008 to December 2014...
March 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28838175/using-acute-flaccid-paralysis-surveillance-as-a-platform-for-vaccine-preventable-disease-surveillance
#18
Steven G F Wassilak, Cheryl L Williams, Christopher S Murrill, Benjamin A Dahl, Chima Ohuabunwo, Rudolf H Tangermann
Surveillance for acute flaccid paralysis (AFP) is a fundamental cornerstone of the global polio eradication initiative (GPEI). Active surveillance (with visits to health facilities) is a critical strategy of AFP surveillance systems for highly sensitive and timely detection of cases. Because of the extensive resources devoted to AFP surveillance, multiple opportunities exist for additional diseases to be added using GPEI assets, particularly because there is generally 1 district officer responsible for all disease surveillance...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838163/using-the-stop-transmission-of-polio-stop-program-to-develop-a-south-sudan-expanded-program-on-immunization-workforce
#19
Dieula D Tchoualeu, Margaret A Hercules, William B Mbabazi, Anthony L Kirbak, Abdulmumini Usman, Ketema Bizuneh, Hardeep S Sandhu
In 2009, the international Stop Transmission of Polio (STOP) program began supporting the Global Polio Eradication Initiative in the Republic of South Sudan to address shortages of human resources and strengthen acute flaccid paralysis surveillance. Workforce capacity support is provided to the South Sudan Expanded Program on Immunization by STOP volunteers, implementing partners, and non-governmental organizations. In 2013, the Polio Technical Advisory Group recommended that South Sudan transition key technical support from external partners to national staff as part of the Polio Eradication and Endgame Strategic Plan, 2013-2018...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28832298/-enterovirus-type-d68-and-acute-flaccid-paralysis-a-new-duo
#20
J T van Dissel, A Meijer
Following a case of acute flaccid paralysis after infection with enterovirus type D68, we highlight current understanding of the causal role of enterovirus infection in this neurological syndrome. Acute flaccid paralysis is a rare complication of enterovirus infections. Such viruses have become a more common cause of severe respiratory-tract infections, especially in children with underlying lung disease such as asthma.
2017: Nederlands Tijdschrift Voor Geneeskunde
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