keyword
https://read.qxmd.com/read/38535607/metagenomic-detection-and-genetic-characterization-of-human-sapoviruses-among-children-with-acute-flaccid-paralysis-in-nigeria
#1
JOURNAL ARTICLE
Uwem Etop George, Temitope O C Faleye, Lander De Coninck, Sheriff Tunde Agbaje, Ijeoma Maryjoy Ifeorah, Bernard Anyebe Onoja, Elijah Igbekele Oni, Adebowale Oluseyi Olayinka, Toluwani Goodnews Ajileye, Arthur Obinna Oragwa, Toluwanimi Emmanuel Akinleye, Bolutife Olubukola Popoola, Oluwadamilola Gideon Osasona, Olaitan Titilola Olayinka, Oluwadamilola Adefunke George, Ahmed Iluoreh Muhammad, Isaac Komolafe, Adekunle Johnson Adeniji, Jelle Matthijnssens, Moses Olubusuyi Adewumi
Using a metagenomic sequencing approach on stool samples from children with Acute Flaccid Paralysis (AFP), we describe the genetic diversity of Sapoviruses (SaVs) in children in Nigeria. We identified six complete genome sequences and two partial genome sequences. Several SaV genogroups and genotypes were detected, including GII (GII.4 and GII.8), GIV (GIV.1), and GI (GI.2 and GI.7). To our knowledge, this is the first description of SaV infections and complete genomes from Nigeria. Pairwise identity and phylogenetic analysis showed that the Nigerian SaVs were related to previously documented gastroenteritis outbreaks with associated strains from China and Japan...
March 19, 2024: Pathogens
https://read.qxmd.com/read/38535541/lower-limb-paralysis-associated-with-chikungunya-in-kinshasa-the-democratic-republic-of-the-congo-survey-report
#2
JOURNAL ARTICLE
Mathy Matungala-Pafubel, Junior Bulabula-Penge, Meris Matondo-Kuamfumu, Samy Esala, François Edidi-Atani, Elisabeth Pukuta-Simbu, Paul Tshiminyi-Munkamba, Yannick Tutu Tshia N'kasar, Trésor Katanga, Etienne Ndomba-Mukanya, Delphine Mbonga-Mande, Lionel Baketana-Kinzonzi, Eddy Kinganda-Lusamaki, Daniel Mukadi-Bamuleka, Fabrice Mambu-Mbika, Placide Mbala-Kingebeni, Edith Nkwembe-Ngabana, Antoine Nkuba-Ndaye, Daniel Okitundu-Luwa, Steve Ahuka-Mundeke
Polio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosis, which is necessary for better management and response. From September 2022 to April 2023, we investigated acute flaccid paralysis (AFP) cases in Kinshasa following an alert from the Provincial Division of Health...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38532142/efgartigimod-in-the-treatment-of-guillain-barr%C3%A3-syndrome
#3
JOURNAL ARTICLE
Huiqiu Zhang, Jing Ma, Yingna Feng, Hui Ma, Dan Liu, Xiaomin Pang, Xueli Chang, Rongjuan Zhao, Juan Wang, Junhong Guo, Wei Zhang
BACKGROUND: Guillain-Barré Syndrome (GBS) is caused by immunoglobulin G (IgG) autoantibodies. Efgartigimod, a human IgG antibody Fc fragment that acts as a natural ligand for the FcRn, can increase IgG degradation, which thus may be a promising therapeutic drug for GBS. CASE PRESENTATION: The two patients presented with postinfectious and acute flaccid paralysis. On admission, they were bedridden. Nerve conduction studies indicated peripheral neuropathy. GBS was suspected and they are treated with two doses of efgartigimod (10 mg/kg) within 5 days...
March 26, 2024: Journal of Neurology
https://read.qxmd.com/read/38508206/-not-available
#4
JOURNAL ARTICLE
Benedikt Schäfer, Justus P Beier, Jörg Bahm
BACKGROUND: The treatment of obstetric brachial plexus palsy through primary reconstruction and nerve transfers has been established in the past decades. In the case of non-traumatic diseases that lead to flaccid paralysis and the inability to move the extremities, such as transverse myelitis (TM) or arthrogryposis multiplex congenita (AMC), which can have a wide variety of causes, the focus has been on rehabilitative therapy so far, while surgical interventions have been used to a lesser extent, e...
February 2024: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/38492637/reflecting-on-the-1998-enterovirus-outbreak-a-25-year-retrospective-and-learned-lessons
#5
REVIEW
Peng-Nien Huang, Shao-Hsuan Hsia, Kuan-Ying Arthur Huang, Chih-Jung Chen, En-Tzu Wang, Shin-Ru Shih, Tzou-Yien Lin
Enterovirus A71 (EV-A71) infections pose a significant public health concern in the Asia-Pacific region. EV-A71 is primarily responsible for causing hand, foot, and mouth disease (HFMD) in children. However, this virus can also lead to severe and potentially fatal neurological consequences in affected individuals. This review aims to provide a comprehensive understanding of the molecular virology, epidemiology, and recombination events associated with EV-A71. The literature extensively covers the clinical manifestations and neurological symptoms that accompany EV-A71 infections...
March 14, 2024: Biomedical Journal
https://read.qxmd.com/read/38488486/diversity-of-enteroviruses-in-cerebrospinal-fluid-specimens-collected-from-hospitalised-patients-in-the-private-and-public-sector-in-south-africa
#6
JOURNAL ARTICLE
Megan Janse van Rensburg, Janet Mans, Rendani T Mafuyeka, Kathy-Anne Strydom, Marcelle Myburgh, Walda B van Zyl
Enteroviruses cause a wide range of neurological illnesses such as encephalitis, meningitis, and acute flaccid paralysis. Two types of enteroviruses, echovirus E4 and E9, have recently been detected in South Africa and are known to be associated with meningitis and encephalitis. The objective of this study was to characterize enterovirus strains detected in cerebrospinal fluid specimens of hospitalized patients in the private and public sector to identify genotypes associated with meningitis and encephalitis...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38484358/occurrence-of-poliovirus-and-non-polio-enterovirus-among-children-with-acute-flaccid-paralysis-in-cameroon-from-2015-to-2020
#7
JOURNAL ARTICLE
Daniel K Njile, Serge A Sadeuh-Mba, Michel Tabonfack Atemkeng, Anicet Ahanda, Jean Blaise Momo, Raissa Pekekue Nforifum, Ernestine Etéré, Marie Claire Endegue-Zanga, Onana Boyomo, Marlise D Djoumetio, Jude Anfumbom Kfutwah, Ousmane M Diop, Richard Njouom
INTRODUCTION: Poliovirus (PV) and non-polio enteroviruses (NPEV) belong to the Picornaviridae family. They are found worldwide and are responsible for a wide range of diseases such as acute flaccid paralysis (AFP). This study aimed to evaluate the detection rate of PV and NPEV in stool samples from children under fifteen years of age presenting with AFP in Cameroon and their distribution over time. METHODOLOGY: Stool samples were collected as part of poliovirus surveillance throughout Cameroon from 2015 to 2020...
February 29, 2024: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38473200/the-most-important-metabolic-diseases-in-dairy-cattle-during-the-transition-period
#8
REVIEW
Vincenzo Tufarelli, Nikola Puvača, Dragan Glamočić, Gianluca Pugliese, Maria Antonietta Colonna
This review paper provides an in-depth analysis of three critical metabolic diseases affecting dairy cattle such as subacute ruminal acidosis (SARA), ketosis, and hypocalcemia. SARA represents a disorder of ruminal fermentation that is characterized by extended periods of depressed ruminal pH below 5.5-5.6. In the long term, dairy herds experiencing SARA usually exhibit secondary signs of the disease, such as episodes of laminitis, weight loss and poor body condition despite adequate energy intake, and unexplained abscesses usually 3-6 months after an episode of SARA...
March 6, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38472067/an-inactivated-whole-virion-vaccine-for-enterovirus-d68-adjuvanted-with-cpg-odn-or-addavax-elicits-potent-protective-immunity-in-mice
#9
JOURNAL ARTICLE
Kota Senpuku, Chikako Kataoka-Nakamura, Yuta Kunishima, Toshiro Hirai, Yasuo Yoshioka
Enterovirus D68 (EV-D68), a pathogen that causes respiratory symptoms, mainly in children, has been implicated in acute flaccid myelitis, which is a poliomyelitis-like paralysis. Currently, there are no licensed vaccines or treatments for EV-D68 infections. Here, we investigated the optimal viral inactivation reagents, vaccine adjuvants, and route of vaccination in mice to optimize an inactivated whole-virion (WV) vaccine against EV-D68. We used formalin, β-propiolactone (BPL), and hydrogen peroxide as viral inactivation reagents and compared their effects on antibody responses...
March 11, 2024: Vaccine
https://read.qxmd.com/read/38465871/botulism-in-fish-a-review
#10
JOURNAL ARTICLE
Francisco A Uzal, Eileen Henderson, Javier Asin
Published information about fish botulism is scant. We review here the current literature on fish botulism. Freshwater fish are susceptible to botulism. Only anecdotal evidence exists about possible botulism cases in saltwater fish. With only a few exceptions, the etiology of all cases of fish botulism reported is Clostridium botulinum type E, although fish are sensitive to, and may carry, various C. botulinum types. Clinical signs of botulism in fish include loss of equilibrium and motion, abducted opercula, open mouths, dark pigmentation, and head up/tail down orientation in which attempts to swim result in breaching the surface of the water...
March 11, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38465811/-modern-aspects-of-diagnosis-and-treatment-of-chronic-inflammatory-demyelinating-polyneuropathy-in-children
#11
JOURNAL ARTICLE
A A Kozyreva, R Ts Bembeeva, E S Druzhinina, N N Zavadenko, L M Kolpakchi, S V Pilia
OBJECTIVE: Analysis of demographic, clinical, laboratory, electrophysiological and neuroimaging data and pathogenetic therapy of pediatric patients with chronic inflammatory demyelinating polyneuropathy (CIDP). MATERIAL AND METHODS: Patients ( n =30) were observed in a separate structural unit of the Russian Children's Clinical Hospital of the Russian National Research Medical University named after. N.I. Pirogova Ministry of Health of the Russian Federation in the period from 2006 to 2023...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38461445/statin-induced-immune-mediated-necrotizing-myopathy-with-concomitant-increase-of-anti-hmgcr-and-anti-achr-antibodies
#12
REVIEW
Razmig Garabet, Sanjeev Herr, Nicole Griffin, Kuruganti Reddy
Statin-induced immune-mediated necrotizing myopathy (IMNM) is a rare systemic neuromuscular condition. We present a case of a patient with a severe phenotype of the disease that was found to have an increase in anti-HMGCR and anti-ACHR antibodies. A potential association between these antibodies have not been previously described. A 67-year-old male with hyperlipidemia, who was recently initiated on atorvastatin therapy, presented to the ED with progressive muscle weakness. Within a few days of admission, the patient developed complete flaccid paralysis and respiratory distress requiring intubation...
March 10, 2024: Rheumatology International
https://read.qxmd.com/read/38458353/validation-of-improved-automated-nucleic-acid-extraction-methods-for-direct-detection-of-polioviruses-for-global-polio-eradication
#13
JOURNAL ARTICLE
Stacey Jeffries Miles, Chelsea Harrington, Hong Sun, Ashley Deas, M Steve Oberste, W Allan Nix, Everardo Vega, Nancy Gerloff
Polioviruses (PV), the main causative agent of acute flaccid paralysis (AFP), are positive-sense single-stranded RNA viruses of the family Picornaviridae. As we approach polio eradication, accurate and timely detection of poliovirus in stool from AFP cases becomes vital to success for the eradication efforts. Direct detection of PV from clinical diagnostic samples using nucleic acid (NA) extraction and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) instead of the current standard method of virus isolation in culture, eliminates the long turn-around time to diagnosis and the need for high viral titer amplification in laboratories...
March 6, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38422061/evaluation-of-the-environmental-polio-surveillance-system-northern-region-ghana-2021
#14
JOURNAL ARTICLE
Benjamin Baguune, Eunice Baiden Laryea, Joseph Asamoah Frimpong, Samuel Dapaa, Kwame Kodom Achempem, Ernest Kenu, Dennis Odai Laryea
BACKGROUND: Acute Flaccid Paralysis (AFP) surveillance is the gold standard in the polio eradication initiative. The environmental component of polio surveillance can detect circulating Polioviruses from sewage without relying on clinical presentation. The effectiveness of the Environmental Surveillance (ES) is crucial to global polio eradication. We assessed the usefulness and attributes of the ES system in the Northern region and determined if the system is meeting its objectives. METHODS: We conducted a descriptive cross-sectional evaluation in the Northern region from 2019 to 2020 using the updated US Centers for Disease Control and Prevention guideline...
2024: PloS One
https://read.qxmd.com/read/38420060/deciphering-the-neuropsychiatric-lupus-enigma-navigating-the-intersection-of-acute-inflammatory-demyelinating-polyneuropathy-aidp-infection-and-flare
#15
Jhasaketan Meher, Jivtesh Singh, Saroj Kumar Pati, Vinay R Pandit, Saurabh K Patel, Mallika Kapur, M S Nithin
A 17-year-old male diagnosed with systemic lupus erythematosus (SLE), showing poor compliance with medication, presented to our facility with a 20-day history of fever, polyarthritis, and cough. Additionally, he had experienced a seizure episode, followed by a one-day history of altered mentation. Subsequently, he developed pneumonia, respiratory distress, and shock, necessitating ventilator and inotropic support. Neuropsychiatric lupus (NP-lupus) was suspected, and hence high-dose steroids, hydroxychloroquine, and broad-spectrum antibiotics were initiated...
January 2024: Curēus
https://read.qxmd.com/read/38406120/a-rare-case-of-hypokalemic-periodic-paralysis-with-acute-urinary-retention-diagnosis-and-management
#16
S Sara, Dhigvijay Tv, Gokulesh Dg, Balaji Elumalai, Mohamed Javid
Hypokalemic periodic paralysis (hypoPP) is a rare channelopathy caused by mutations in skeletal muscle ion channels that usually occurs in young individuals and adolescents. The etiology can be attributed to various factors, such as idiopathic or secondary causes. It is characterized by episodes of sudden flaccid muscle weakness. Timely detection may mitigate the risk of severe complications. Secondary causes of hypoPP, such as hyperthyroidism, should be ruled out, as this could lead to thyrotoxic periodic paralysis...
January 2024: Curēus
https://read.qxmd.com/read/38403608/-research-on-mode-adjustment-control-strategy-of-upper-limb-rehabilitation-robot-based-on-fuzzy-recognition-of-interaction-force
#17
JOURNAL ARTICLE
Guoning Li, Liang Tao, Jingyan Meng, Sijia Ye, Guang Feng, Dazheng Zhao, Yang Hu, Min Tang, Tao Song, Rongzhen Fu, Guokun Zuo, Jiaji Zhang, Changcheng Shi
In the process of robot-assisted training for upper limb rehabilitation, a passive training strategy is usually used for stroke patients with flaccid paralysis. In order to stimulate the patient's active rehabilitation willingness, the rehabilitation therapist will use the robot-assisted training strategy for patients who gradually have the ability to generate active force. This study proposed a motor function assessment technology for human upper-limb based on fuzzy recognition on interaction force and human-robot interaction control strategy based on assistance-as-needed...
February 25, 2024: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://read.qxmd.com/read/38402605/classic-human-astrovirus-4-8-mlb-3-and-likely-new-genotype-5-sublineage-in-stool-samples-of-children-in-nigeria
#18
JOURNAL ARTICLE
Ifeorah M Ijeomah, Faleye O C Temitope, De Coninck Lander, Agbaje T Sheriff, George E Uwem, Onoja A Bernard, Olayinka A Oluseyi, Oni I Elijah, Ajileye G Toluwani, Oragwa O Arthur, Akinleye E Toluwanimi, Popoola O Bolutife, Osasona G Damilola, Olayinka O Titilola, George A Oluwadamilola, Ahmed I Muhammad, Komolafe I Omotosho, Adeniji A Johnson, Matthijnssens Jelle, Adewumi M Olubusuyi
Human astrovirus (HAstV) is a nonenveloped RNA virus and has been implicated in acute gastroenteritis among children and elderly. However, there exists a substantial dearth of information on HAstV strains circulating in Nigeria. Viral-like particles were purified from archived 254 stool samples of children with acute flaccid paralysis between January and December 2020 from five states in Nigeria, using the NetoVIR protocol. Extracted viral RNA and DNA were subjected to a reverse transcription step and subsequent random polymerase chain reaction amplification...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38389637/incidence-of-cardiovascular-instability-in-patients-with-guillain-barr%C3%A3-syndrome-a-retrospective-study
#19
JOURNAL ARTICLE
Noel James, Sanjeeva Reddy, Uma Maheshwari, Natarajan Elamurugan, Nirumal Kumar, Arun N Kumar, Sathya D Tejaswini, Lakshmi Narasimhan Ranganathan, Balasubramanian S
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease affecting radicles and peripheral nerves resulting in acute flaccid paralysis. Respiratory failure, autonomic dysfunction, and secondary complications such as pneumonia, and venous thromboembolism are the major causes of death and disability in GBS. Cardiovascular complications play a major role in the prognosis of GBS patients. The aim is to determine the incidence of cardiovascular instability in GBS patients and to see if there are any specific risk groups associated with the development of cardiovascular instability...
January 2024: Curēus
https://read.qxmd.com/read/38384598/the-polio-vaccination-status-of-non-polio-acute-flaccid-paralysis-cases-in-the-far-north-region-of-cameroon-a-five-year-retrospective-study-from-2015-to-2019
#20
JOURNAL ARTICLE
Blaise Wakam Nkontchou, Etienne Guenou, Collins Buh Nkum, Celine Mairousgou Tchida, Alphonse Marie Nono, Jerome Ateudjieu
BACKGROUND:  The Expanded Program on Immunization (EPI) of Cameroon contributes to the reduction of polio, but the rate of non-polio acute flaccid paralysis (NPAFP) is still high. The aim of this study was to describe the immunization profile of NPAFP cases and the performance of polio surveillance in the Far North Region of Cameroon between 2015 and 2019. METHODS: A retrospective secondary data analysis was conducted using the national EPI and regional AFP surveillance case-based database from 2015 to 2019...
January 2024: Curēus
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