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Flaccid paralysis

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https://www.readbyqxmd.com/read/28630462/identification-and-molecular-characterization-of-non-polio-enteroviruses-from-children-with-acute-flaccid-paralysis-in-west-africa-2013-2014
#1
Maria D Fernandez-Garcia, Ousmane Kebe, Aichatou D Fall, Kader Ndiaye
Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630226/thyrotoxic-periodic-paralysis-as-an-initial-presentation-of-graves-disease-in-a-saudi-patient
#2
S F Alqahtani, M M Aleithan
Thyrotoxic periodic paralysis (TPP) is a well-known complication of hyperthyroidism, characterised by recurrent flaccid paralysis with hypokalaemia. To date, only five cases of this rare disorder have been reported in Saudi Arabia. Here, we report an additional case involving a 25-year-old Saudi man who presented with lower limb paralysis and severe hypokalaemia. Clinically, he showed symptoms and signs suggestive of Graves' disease, which was confirmed by laboratory investigations. Carbimazole, a beta-blocker and potassium replacement were administered, resulting in dramatic improvement of the TTP...
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28626021/acute-segmental-poliomyelitis-like-flaccid-paralysis-in-an-adult-in-the-uk-associated-with-enterovirus-d68
#3
Sybil R L Stacpoole, Adam Molyneux, Dirk Bäumer
Enterovirus D68 has been associated with a poliomyelitis-like illness, notably during an outbreak in 2014, and particularly affecting children in the USA. We report a case of acute segmental flaccid paralysis with respiratory involvement in an adult in the UK, with enterovirus D68 detected in a sputum sample. MR imaging of cervical spinal cord showed a longitudinally extensive T2 hyperintensity in the anterior cord. Cerebrospinal fluid showed an elevated white cell count, predominantly lymphocytic, with otherwise normal constituents and negative viral PCRs...
June 16, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28612001/botulinum-toxin-off-label-use-in-dermatology-a-review
#4
REVIEW
Anna Campanati, Emanuela Martina, Katia Giuliodori, Veronica Consales, Ivan Bobyr, Annamaria Offidani
BACKGROUND: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. OBJECTIVE: To review and analyze the possible botulinum toxin off-label applications published. METHODS: A retrospective review of the published data was conducted...
March 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28604777/risk-factors-and-short-term-projections-for-serotype-1-poliomyelitis-incidence-in-pakistan-a-spatiotemporal-analysis
#5
Natalie A Molodecky, Isobel M Blake, Kathleen M O'Reilly, Mufti Zubair Wadood, Rana M Safdar, Amy Wesolowski, Caroline O Buckee, Ananda S Bandyopadhyay, Hiromasa Okayasu, Nicholas C Grassly
BACKGROUND: Pakistan currently provides a substantial challenge to global polio eradication, having contributed to 73% of reported poliomyelitis in 2015 and 54% in 2016. A better understanding of the risk factors and movement patterns that contribute to poliovirus transmission across Pakistan would support evidence-based planning for mass vaccination campaigns. METHODS AND FINDINGS: We fit mixed-effects logistic regression models to routine surveillance data recording the presence of poliomyelitis associated with wild-type 1 poliovirus in districts of Pakistan over 6-month intervals between 2010 to 2016...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28596404/complete-genome-sequence-of-human-echovirus-20-strain-812-yn-chn-2010-associated-with-severe-hand-foot-and-mouth-disease
#6
Yilin Zhao, Haihao Zhang, Hongbo Liu, Hao Sun, Xiaoqin Huang, Zhaoqing Yang, Shaohui Ma
Human echovirus 20 (E-20) belongs to the Human enterovirus B (HEV-B) species and is often detected in nonpolio enterovirus cases of acute flaccid paralysis. We determined the complete genome of strain 812/YN/CHN/2010, isolated from a child with severe hand-foot-and-mouth disease in Yunnan, China, in 2010.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28584101/deubiquitinating-enzyme-vcip135-dictates-the-duration-of-botulinum-neurotoxin-type-a-intoxication
#7
Yien Che Tsai, Archana Kotiya, Erkan Kiris, Mei Yang, Sina Bavari, Lino Tessarollo, George A Oyler, Allan M Weissman
Botulism is characterized by flaccid paralysis, which can be caused by intoxication with any of the seven known serotypes of botulinum neurotoxin (BoNT), all of which disrupt synaptic transmission by endoproteolytic cleavage of SNARE proteins. BoNT serotype A (BoNT/A) has the most prolonged or persistent effects, which can last several months, and exerts its effects by specifically cleaving and inactivating SNAP25. A major factor contributing to the persistence of intoxication is the long half-life of the catalytic light chain, which remains enzymatically active months after entry into cells...
June 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28582560/the-critical-role-of-acute-flaccid-paralysis-surveillance-in-the-global-polio-eradication-initiative
#8
Rudolf H Tangermann, Christine Lamoureux, Graham Tallis, Ajay Goel
Acute flaccid paralysis (AFP) surveillance is a key strategy used by the Global Polio Eradication Initiative (GPEI) to measure progress towards reaching the global eradication goal. Supported by a global polio laboratory network, AFP surveillance is conducted in 179 of 194 WHO member states. Active surveillance visits to priority health facilities are used to assure all children <15 years with AFP are detected, followed by stool specimen collection and testing for poliovirus in WHO-accredited polio laboratories...
May 1, 2017: International Health
https://www.readbyqxmd.com/read/28582553/-silent-and-noisy-areas-acute-flaccid-paralysis-surveillance-at-subnational-level-australia-2001-2015
#9
Michelle Butler, Beverley J Paterson, Nicolee Martin, Linda Hobday, Bruce Thorley, David N Durrheim
Background: Acute flaccid paralysis (AFP) surveillance rates are used as an indicator of surveillance sensitivity to detect poliomyelitis with an expected rate of ≥1 case per 100 000 population in children under 15 years of age. Methods: The Australian AFP detection rates at sub-national (statistical local area) level were analysed using χ2 goodness of fit tests and exact Poisson probabilities for the combined years 2001-2015 to detect 'silent areas', which may require improved AFP detection efforts, and areas with greater than expected rates, which may indicate unexplained clusters such as those due to enterovirus infection...
May 1, 2017: International Health
https://www.readbyqxmd.com/read/28555456/-acute-polyneuropathies-in-a-hospital-in-the-south-of-spain-ten-years-experience
#10
M M Alonso-Montejo, M C Pradillo, E E Moreno-Medinilla, P Navas-Sanchez, J L Martinez-Anton
INTRODUCTION: Guillain-Barre syndrome is the most frequent cause of acute flaccid paralysis in children. AIM: To describe the characteristics of patients diagnosed with acute polyneuropathies and their long-term progress. PATIENTS AND METHODS: We conducted a retrospective descriptive analysis of children under 14 years of age admitted to our hospital between January 2004 and December 2014. Clinical, demographic and neurophysiological variables were collected together with other imaging tests...
June 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28526462/-sudden-motor-and-sensorial-loss-due-to-retroperitoneal-hematoma-during-postoperative-periods-a-case-report
#11
Pelin Şen, Havva Gül Gültekin, İsmail Caymaz, Ömer Özel, Ayda Türköz
A 68 year-old male patient was hospitalized for radical prostatectomy. He had no abnormal medical history including neurological deficit before the operation. Prior to general anesthesia, an epidural catheter was inserted in the L3-4 interspace for intraoperative and postoperative analgesia. After surgery for nine hours, he developed confusion and flaccid paralysis of bilateral lower extremities occurred. No pathology was detected from cranial computed tomography and diffusion magnetic resonance imaging no pathology was detected...
May 16, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28492795/anterior-spinal-artery-syndrome-following-coronary-artery-bypass-grafting-a-case-report
#12
Seyed Mohsen Mirhosseini, Soheil Meghdadi, Ali Sanjari Moghaddam
We present a patient with unstable angina candidate for coronary artery bypass grafting. Saphenous vein graft was used in obtuse marginal and left internal mammary artery to left anterior descending artery properly. After surgery, the patient experienced flaccid paralysis of lower limb and impaired sensation of touch and warmth of knee and below. A computed tomography angiogram of lower limbs and thoracolumbar magnetic resonance imaging showed no abnormality. Based on the symptom, clinical diagnosis of anterior spinal artery syndrome was considered...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28484930/heart-shaped-bilateral-medullary-pyramidal-infarction-as-a-pathognomonic-finding-of-anterior-spinal-artery-occlusion
#13
Sammy Searcy, Oluwaseun O Akinduro, Andrew Spector, Jang W Yoon, Benjamin L Brown, William D Freeman
BACKGROUND: Unilateral anterior spinal artery (ASA) occlusion resulting in bilateral medullary pyramidal (BMP) infarction is a rare and devastating stroke subtype. We present two cases highlighting the diagnostic and clinical challenges of BMP infarction. METHODS: Case reports and literature review. RESULTS: A 57-year-old man rapidly had severe vomiting and diarrhea 2 h after a meal. Examination revealed bulbar weakness and areflexic tetraplegia...
May 8, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28480271/epidemiological-surveillance-of-poliomyelitis-during-the-military-and-political-conflict-in-the-central-african-republic-2013-and-2014
#14
Alain Farra, Ella C Gonofio, Alexandre Manirakiza, Arthur Mazitchi, Raphaël Mbaïlao, Casimir Manengu, Ionela Gouandjika-Vasilache
BACKGROUND: Since December 2012, the Central African Republic (CAR) has been undergoing a severe military and political conflict. This situation has resulted in general insecurity and total disorganization of surveillance activities, including those for acute flaccid paralysis (AFP). In this study, we used laboratory data to evaluate surveillance of AFP in 2013 and 2014, the most critical period of the conflict. METHODS: The laboratory data on AFP were analyzed retrospectively for the age, sex, vaccination status (oral poliovirus vaccines), and geographical origin of the samples...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28471617/causality-assessment-of-serious-neurologic-adverse-events-following-bopv-national-vaccination-campaign-in-israel
#15
Diana Tasher, Eran Kopel, Emilia Anis, Zachi Grossman, Eli Somekh
BACKGROUND: During 2013-2014 Israel experienced a continuous circulation of wild poliovirus type 1 (WPV1) but with no clinical cases. WPV1 circulation was gradually terminated following a national vaccination campaign of bivalent oral poliovirus vaccine (bOPV) for 943,587 children < 10 years. Four cases of children with neurological manifestations that appeared following bOPV vaccinations were reported during the campaign: three of Guillain-Barré syndrome (GBS) and one of acute disseminated encephalomyelitis (ADEM)...
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28468063/-health-related-quality-of-life-on-severe-hand-foot-and-mouth-disease-patients
#16
Y M Zheng, J Yang, Q H Liao
Objective: To evaluate the health related quality of life (HRQoL) for severe hand, foot and mouth disease (HFMD) patients with different complications. Methods: A national telephone interview under the EQ-5D proxy2 questionnaire (EQ-SD and EQ-VAS), was conducted to obtain the HRQoL of lab-confirmed severe HFMD patients, aged between six months and five-year-olds from the national communicable disease surveillance system from January 1, 2012 to December 31, 2013. Results: A total of 685 severe HFMD cases were included in the study...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28443999/first-reported-enterovirus-d68-infection-in-pediatric-patients-from-the-caribbean-region-evidence-of-spread-from-the-u-s-outbreak
#17
SueMin Nathaniel, Shalauddin Ahmed, Jennifer Wilson, Cristina Gutierrez, Dave D Chadee, Babatunde Olowokure, Pablo M de Salazar
The 2014 enterovirus D68 (EV-D68) outbreak in the United States raised concerns about the introduction of the virus in the Caribbean region. The objective of this study was to provide rapid evidence of the introduction of EV-D68 strains in the Caribbean region during the 2014 outbreak in the United States, using a relatively simple phylogenetic approach. From October 2014 to May 2015, four EV-D68 cases from two countries (Bermuda and Dominica) were detected at the regional referral laboratory at the Caribbean Public Health Agency (Port of Spain, Trinidad and Tobago) based on molecular testing of respiratory specimens...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28412073/pediatric-acute-flaccid-paralysis-enterovirus-d68-associated-anterior-myelitis
#18
James A Yoder, Michael Lloyd, Luke Zabrocki, Jonathan Auten
BACKGROUND: Enteroviral infections can cause acute flaccid paralysis secondary to anterior myelitis. Magnetic resonance imaging (MRI) is important in the diagnosis of this potentially devastating pediatric disease. Before the 2014 outbreak of Enterovirus D68 (EV-D68), the virus was considered a relatively benign disease. CASE REPORT: A fully immunized 8-year-old boy was brought to the emergency department complaining of a cough, headache, neck pain, and right arm pain and weakness...
April 12, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28390186/acute-flaccid-paralysis-surveillance-in-bosnia-and-herzegovina-recent-isolation-of-two-sabin-like-type-2-poliovirus
#19
Stefano Fontana, Gabriele Buttinelli, Stefano Fiore, Mirsada Mulaomerovic, Jela Aćimović, Concetta Amato, Roberto Delogu, Giovanni Rezza, Paola Stefanelli
The WHO Regional Commission for the Certification of Poliomyelitis Eradication has recently indicated Bosnia and Herzegovina (B&H) as a high risk country for transmission, following importation, of wild poliovirus (WPV) or circulating vaccine-derived poliovirus (cVDPV). We analyzed data on Acute Flaccid Paralysis (AFP) surveillance between 2007 to 2016, and the trend of polio immunization coverage in B&H. The majority of AFP cases was recorded in 2016 suggesting an enhancement of the AFP surveillance activities...
April 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28387112/175-performance-of-acute-flaccid-paralysis-afp-surveillance-and-incidence-of-poliomyelitis-2017
#20
(no author information available yet)
No abstract text is available yet for this article.
April 7, 2017: Relevé épidémiologique Hebdomadaire
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