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https://www.readbyqxmd.com/read/28632298/patient-med-tbe-f%C3%A3-rb%C3%A3-ttrades-snabbt-vid-behandling-med-kortison-evidens-saknas-dock-f%C3%A3-r-v%C3%A3-rdet-av-immunmodulerande-terapi
#1
Carl Wengse, Jesper Ericsson, Susanna Hallberg, Johan Ursing
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe...
June 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28628438/haemophilus-influenzae-type-a-meningitis-in-immunocompetent-child-oman-2015
#2
Kiran P Sawardekar
Meningitis caused by Haemophilus influenzae type b (Hib) was eliminated in Oman after the introduction of Hib vaccine in 2001. However, a case of H. influenzae type a meningitis was diagnosed in a child from Oman in 2015, which highlights the need to monitor the incidence of invasive non-Hib H. influenzae disease.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28606106/perceptions-of-measles-pneumonia-and-meningitis-vaccines-among-caregivers-in-shanghai-china-and-the-health-belief-model-a-cross-sectional-study
#3
Abram L Wagner, Matthew L Boulton, Xiaodong Sun, Bhramar Mukherjee, Zhuoying Huang, Irene A Harmsen, Jia Ren, Brian J Zikmund-Fisher
BACKGROUND: In China, the measles vaccine is offered for free whereas the pneumococcal vaccine is a for-fee vaccine. This difference has the potential to influence how caregivers evaluate whether a vaccine is important or necessary for their child, but it is unclear if models of health behavior, such as the Health Belief Model, reveal the same associations for different diseases. This study compares caregiver perceptions of different diseases (measles, pneumonia and meningitis); and characterizes associations between Health Belief Model constructs and both pneumococcal vaccine uptake and perceived vaccine necessity for pneumonia, measles, and meningitis...
June 12, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28605414/childhood-deaths-attributable-to-invasive-pneumococcal-disease-in-england-and-wales-2006-2014
#4
Godwin Oligbu, Sarah Collins, Carmen L Sheppard, Norman K Fry, Mary Slack, Ray Borrow, Shamez N Ladhani
Background.: Pneumococcal conjugate vaccines (PCVs) are highly effective in preventing invasive pneumococcal disease (IPD), but deaths due to IPD still occur. We aimed to describe children who died of IPD since PCV introduction in England and Wales. Methods.: Public Health England conducts enhanced IPD surveillance in England and Wales. IPD cases in PCV-eligible children aged <5 years (born since 4 September 2004 and diagnosed between 4 September 2006 and 3 September 2014) were actively followed up by postal questionnaires and, for fatal cases, detailed information was requested prospectively from multiple sources...
June 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28604773/surveillance-of-impact-of-pcv-10-vaccine-on-pneumococcal-meningitis-in-mozambique-2013-2015
#5
Aquino Albino Nhantumbo, Goitom Weldegebriel, Reggis Katsande, Linda de Gouveia, Charlotte Elizabeth Comé, Arlindo Zacarias Cuco, Vlademir Vicente Cantarelli, Cícero Dias, Juliana Caierão, Jason Mwenda Mathiu, Eduardo Samo Gudo
BACKGROUND: Vaccination using the 10-valent conjugate vaccine (PCV-10) was introduced into the Extended Program on Immunization in Mozambique in March 2013, however its impact on pediatric pneumococcal meningitis is unknown. In this study, we assessed for the first time the impact of PCV10 on the burden of pneumococcal meningitis in children less than 5 years of age at the three largest hospitals in Mozambique. METHOD: Between March 2013 and December 2015, a total of 744 cerebrospinal fluid (CSF) samples were collected from eligible children, of which 160 (21...
2017: PloS One
https://www.readbyqxmd.com/read/28600447/the-epidemiology-management-and-outcomes-of-bacterial-meningitis-in-infants
#6
Lynda Ouchenir, Christian Renaud, Sarah Khan, Ari Bitnun, Andree-Anne Boisvert, Jane McDonald, Jennifer Bowes, Jason Brophy, Michelle Barton, Joseph Ting, Ashley Roberts, Michael Hawkes, Joan L Robinson
OBJECTIVES: The pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed in this era of increasing antimicrobial resistance, use of conjugated vaccines, and maternal antibiotic prophylaxis for group B Streptococcus (GBS). The objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy. METHODS: This was a cohort study of infants <90 days of age with bacterial meningitis at 7 pediatric tertiary care hospitals across Canada in 2013 and 2014...
June 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28598805/meningococcal-disease-awareness-and-meningoccocal-vaccination-among-greek-students-planning-to-travel-abroad
#7
Androula Pavli, Panagiotis Katerelos, Helena C Maltezou
Objective Students living in dormitories are at increased risk for meningococcal disease. Our aim was to evaluate Greek students planning to study abroad about their level of meningococcal disease awareness and attitudes and practices towards meningococcal vaccination. Methods We studied 231 Greek ERASMUS students using a questionnaire. Results Students had a mean number of 4.1 correct answers out of six questions. In particular 66.5% 79.3%, 72.3% and 82.3% of them answered correctly about the etiology, transmission, epidemiology and treatment of meningococcal disease, respectively...
June 9, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28592578/bacterial-meningitis-in-finland-1995-2014-a-population-based-observational-study
#8
Aleksandra Polkowska, Maija Toropainen, Jukka Ollgren, Outi Lyytikäinen, J Pekka Nuorti
OBJECTIVES: Bacterial meningitis remains an important cause of morbidity and mortality worldwide. Its epidemiological characteristics, however, are changing due to new vaccines and secular trends. Conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae (10-valent) were introduced in 1986 and 2010 in Finland. We assessed the disease burden and long-term trends of five common causes of bacterial meningitis in a population-based observational study. METHODS: A case was defined as isolation of S...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28584980/heat-killed-yeast-as-a-pan-fungal-vaccine
#9
Marife Martinez, Karl V Clemons, David A Stevens
Fungal infections continue to rise worldwide. Antifungal therapy has long been a mainstay for the treatment of these infections, but often can fail for a number of reasons. These include acquired or innate drug resistance of the causative agent, poor drug penetration into the affected tissues, lack of cidal activity of the drug and drug toxicities that limit therapy. In some instances, such as coccidioidal meningitis, therapy is life-long. In addition, few new antifungal drugs are under development. In light of this information a preventative vaccine is highly desirable...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28579230/comparative-incidence-dynamics-and-serotypes-of-meningitis-bacteremic-pneumonia-and-other-ipd-in-young-children-in-the-pcv-era-insights-from-israeli-surveillance-studies
#10
Shalom Ben-Shimol, Noga Givon-Lavi, Galia Grisaru-Soen, Orli Megged, David Greenberg, Ron Dagan
INTRODUCTION: Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumonia) IPD episodes in children <5years in Israel. METHODS: A prospective, population-based, active nationwide surveillance. All pneumococcal invasive episodes with positive blood/CSF cultures, July 2000 through June 2016, were included...
June 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28570694/trends-of-vaccine-preventable-diseases-in-afghanistan-from-the-disease-early-warning-system-2009-2015
#11
Abram L Wagner, Mohammad Y Mubarak, Laura E Johnson, Julia M Porth, Jenna E Yousif, Matthew L Boulton
BACKGROUND: Afghanistan's public health system was neglected during decades of military and civil conflict, and trends in infectious disease occurrence remain poorly characterized. This study examines cyclical and long-term trends of six vaccine-preventable diseases: pneumonia, diarrhea, meningitis, typhoid, measles, and acute viral hepatitis. METHODS: Using weekly data collected between 2009 and 2015 through Afghanistan's Disease Early Warning System, we calculated monthly case counts, and fit a Poisson regression with a Fourier transformation for seasonal cycles and dummy variables for year...
2017: PloS One
https://www.readbyqxmd.com/read/28558983/enhancing-global-vaccine-pharmacovigilance-proof-of-concept-study-on-aseptic-meningitis-and-immune-thrombocytopenic-purpura-following-measles-mumps-containing-vaccination
#12
Silvia Perez-Vilar, Daniel Weibel, Miriam Sturkenboom, Steven Black, Christine Maure, Jose Luis Castro, Pamela Bravo-Alcántara, Caitlin N Dodd, Silvana A Romio, Maria de Ridder, Swabra Nakato, Helvert Felipe Molina-León, Varalakshmi Elango, Patrick L F Zuber
New vaccines designed to prevent diseases endemic in low and middle-income countries (LMICs) are now being introduced without prior record of utilization in countries with robust pharmacovigilance systems. To address this deficit, our objective was to demonstrate feasibility of an international hospital-based network for the assessment of potential epidemiological associations between serious and rare adverse events and vaccines in any setting. This was done through a proof-of-concept evaluation of the risk of immune thrombocytopenic purpura (ITP) and aseptic meningitis (AM) following administration of the first dose of measles-mumps-containing vaccines using the self-controlled risk interval method in the primary analysis...
May 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28557635/adolescent-vaccines-latest-recommendations-addressing-barriers-and-improving-vaccine-rates
#13
Kathleen C Rose
The Advisory Committee on Immunization Practices recommends that the Tdap, HPV, and meningitis vaccines be administered to youth beginning between the ages of 11 and 12. The school nurse, knowledgeable about vaccine schedules and the rationale for the schedules, is in a unique position to advocate for all adolescent vaccines and their timely administration through addressing parent-guardian concerns and supporting other healthcare providers in completing the adolescent vaccines. This article reviews current recommendations for adolescent vaccinations and the actions needed to improve vaccination rates with a focus on Human Papillomavirus vaccine, the vaccine with the lowest completion rates among this age group...
May 1, 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28545721/impact-of-menafrivac-in-nine-countries-of-the-african-meningitis-belt-2010-15-an-analysis-of-surveillance-data
#14
Caroline L Trotter, Clément Lingani, Katya Fernandez, Laura V Cooper, André Bita, Carol Tevi-Benissan, Olivier Ronveaux, Marie-Pierre Préziosi, James M Stuart
BACKGROUND: In preparation for the introduction of MenAfriVac, a meningococcal group A conjugate vaccine developed for the African meningitis belt, an enhanced meningitis surveillance network was established. We analysed surveillance data on suspected and confirmed cases of meningitis to quantify vaccine impact. METHODS: We compiled and analysed surveillance data for nine countries in the meningitis belt (Benin, Burkina Faso, Chad, Côte d'Ivoire, Ghana, Mali, Niger, Nigeria, and Togo) collected and curated by the WHO Inter-country Support Team between 2005 and 2015...
May 22, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28528009/identification-of-novel-haemophilus-parasuis-serovar-5-vaccine-candidates-using-an-immunoproteomic-approach
#15
Gang Li, Fang Xie, Jianjun Li, Jiao Liu, Dapeng Li, Yanhe Zhang, Paul R Langford, Yanwen Li, Siguo Liu, Chunlai Wang
Haemophilus parasuis is the aetiological agent of Glässer's disease, which is responsible for cases of fibrinous polyserositis, polyarthritis and meningitis. No vaccine is known that provides cross-protection against all serovars. The identification of novel immunoprotective antigens would undoubtedly contribute to the development of efficient subunit vaccines. In the present study, an immunoproteomic approach was used to analyze secreted proteins of H. parasuis and six proteins with high immunogenicity were identified...
May 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28523054/acute-bacterial-meningitis-in-children-presenting-to-the-children-s-hospital-lahore-before-and-after-pneumococcal-vaccine-in-pakistan-national-immunization-program-a-comparison
#16
Attia Bari, Fatima Zeeshan, Aizza Zafar, Hasan Ejaz, Uzma Jabeen, Ahsan Waheed Rathore
OBJECTIVE: To describe bacteriological profile, morbidity and mortality of acute bacterial meningitis (ABM) in children and to compare these parameters before and after the introduction of Pneumococcal vaccine in Pakistan National Immunization Program. METHODS: The present descriptive study was conducted at the Department of Paediatric Medicine of The Children's Hospital Lahore from January 2012 to December 2015. A total of 503 children one month to five years of age admitted with diagnosis of meningitis were included...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28522212/bioengineering-bacterial-outer-membrane-vesicles-as-vaccine-platform
#17
REVIEW
Matthias J H Gerritzen, Dirk E Martens, René H Wijffels, Leo van der Pol, Michiel Stork
Outer membrane vesicles (OMVs) are naturally non-replicating, highly immunogenic spherical nanoparticles derived from Gram-negative bacteria. OMVs from pathogenic bacteria have been successfully used as vaccines against bacterial meningitis and sepsis among others and the composition of the vesicles can easily be engineered. OMVs can be used as a vaccine platform by engineering heterologous antigens to the vesicles. The major advantages of adding heterologous proteins to the OMV are that the antigens retain their native conformation, the ability of targeting specific immune responses, and a single production process suffices for many vaccines...
May 15, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28516066/the-alpha-tocopherol-form-of-vitamin-e-boosts-elastase-activity-of-human-pmns-and-their-ability-to-kill-streptococcus-pneumoniae
#18
Elsa N Bou Ghanem, James N Lee, Basma H Joma, Simin N Meydani, John M Leong, Alexander Panda
Despite the availability of vaccines, Streptococcus pneumoniae remains a leading cause of life-threatening infections, such as pneumonia, bacteremia and meningitis. Polymorphonuclear leukocytes (PMNs) are a key determinant of disease course, because optimal host defense requires an initial robust pulmonary PMN response to control bacterial numbers followed by modulation of this response later in infection. The elderly, who manifest a general decline in immune function and higher basal levels of inflammation, are at increased risk of developing pneumococcal pneumonia...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28513815/epidemiology-of-paediatric-meningitis-in-central-c%C3%A3-te-d-ivoire-after-the-implementation-of-haemophilus-influenzae-type-b-vaccination
#19
Fidèle S Touré, Samson Kouame, Honoré Tia, Pacôme Monemo, Amadou Cissé, Bamourou Diané, Sören L Becker, Chantal Akoua-Koffi
Infectious meningitis accounts for enormous morbidity worldwide, but there is a paucity of data on its regional epidemiology in resource-constrained settings of sub-Saharan Africa. Here, we present a study on the aetiology of paediatric meningitis in central Côte d'Ivoire. Between June 2012 and December 2013, all cerebrospinal fluid (CSF) samples drawn at the University Teaching Hospital Bouaké were examined for the presence of bacterial and fungal pathogens. A causative agent was detected in 31 out of 833 CSF specimens (3...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28508419/case-control-study-shows-that-neonatal-pneumococcal-meningitis-cannot-be-distinguished-from-group-b-streptococcus-cases
#20
Alexandra Arfi, Robert Cohen, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Corinne Levy
AIM: Streptococcus pneumoniae (S. pneumoniae) is sometimes implicated in neonatal bacterial meningitis. This study described the demographic, clinical and biological features of neonatal S. pneumoniae meningitis and compared pneumococcal and group B streptococcal (GBS) neonatal meningitis. METHODS: We conducted a case-control study that compared neonates, aged one to 28 days with S. pneumoniae meningitis or GBS meningitis. Each case with S. pneumoniae was randomly matched to four control patients with GBS by age group and study year...
May 16, 2017: Acta Paediatrica
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