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https://www.readbyqxmd.com/read/28069798/integrative-comparison-of-mrna-expression-patterns-in-breast-cancers-from-caucasian-and-asian-americans-with-implications-for-precision-medicine
#1
Yanxia Shi, Albert Steppi, Ye Cao, Jianan Wang, Max M He, Liren Li, Jinfeng Zhang
Asian Americans (AS) have significantly lower incidence and mortality rates of breast cancer than Caucasian Americans (CA). Although this racial disparity has been documented, the underlying pathogenetic factors explaining it are obscure. We addressed this issue by an integrative genomics approach to compare mRNA expression between AS and CA cases of breast cancer. RNA-seq data from the Cancer Genome Atlas showed that mRNA expression revealed significant differences at gene and pathway levels. Increased susceptibility and severity in CA patients were likely the result of synergistic environmental and genetic risk factors, with arachidonic acid metabolism and PPAR signaling pathways implicated in linking environmental and genetic factors...
November 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/28052821/micrornas-and-their-impact-on-breast-cancer-the-tumor-microenvironment-and-disparities
#2
A Evans-Knowell, A C LaRue, V J Findlay
Breast cancer is a worldwide health issue as it represents the leading cause of cancer in women and the second-leading cause of cancer-related mortality in women, with an increasing incidence. Nothing speaks more clearly to the shocking breast cancer health disparities than the fact that African American (AA) women are as likely to get breast cancer as Caucasian American (CA) women, yet have a higher breast cancer death rate. It is becoming increasingly apparent that racial disparity in cancer exists due to molecular differences in tumor biology as well as, or in addition to, socioeconomic and standard of care issues (Albain, Unger, Crowley, Coltman, & Hershman, 2009)...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28051137/distinct-prognostic-values-of-s100-mrna-expression-in-breast-cancer
#3
Shizhen Zhang, Zhen Wang, Weiwei Liu, Rui Lei, Jinlan Shan, Ling Li, Xiaochen Wang
S100 family genes encode low molecular weight, acidic-Ca(2+) binding proteins implicating in a wide spectrum of biological processes. S100 family contains at least 20 members, most of which are frequently dysregulated in human malignancies including breast cancer. However, the prognostic roles of each individual S100, especially the mRNA level, in breast cancer patients remain elusive. In the current study, we used "The Kaplan-Meier plotter" (KM plotter) database to investigate the prognostic values of S100 mRNA expression in breast cancer...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28051026/blood-oxygenation-level-dependent-magnetic-resonance-imaging-of-breast-cancer-correlation-with-carbonic-anhydrase-ix-and-vascular-endothelial-growth-factor
#4
Ying Wang, Min Liu, Mu-Lan Jin
BACKGROUND: Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is a functional MRI technique which involves using the paramagnetic properties of deoxyhemoglobin to image the local tissue oxygen concentration. The purpose of this study was to investigate whether BOLD-MRI could evaluate hypoxia and angiogenesis of breast invasive ductal carcinoma (IDC). METHODS: Ninety-eight female patients with IDC were retrospectively included in this research...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28049241/predictive-value-of-dental-maturity-for-a-positive-gonadotropin-releasing-hormone-stimulation-test-result-in-girls-with-precocious-puberty
#5
Jee Seon Baik, Jin Woo Choi, Su Jin Kim, Ji Hyun Kim, Sollip Kim, Jae Hyun Kim
Dental maturity is associated with skeletal maturity, which is advanced in girls with central precocious puberty (CPP). We investigated the performance of dental maturity as a screening method for CPP using mandibular second premolar and molar calcification stages, assessed the associated anthropometric and laboratory factors, and evaluated pubertal response predictors using the gonadotropin-releasing hormone stimulation test (GnRHST) in prepubertal and pubertal girls. A prospective case-control study was conducted in girls, aged 7...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28047327/su-f-t-279-impact-of-beam-energy-drifts-on-imrt-delivery-accuracy
#6
S Goddu, G Kamal, A Herman, S Edwards, S Yaddanapudi, S Oddiraju, B Cai, D Rangaraj, S Mutic
PURPOSE: According to TG-40 percent-depth-dose (PDD) tolerance is ±2% but TG-142 is ±1%. Now the question is, which one is relevant in IMRT era? The primary objective of this study is to evaluate dosimetric impact of beam-energy-drifts on IMRT-delivery. METHODS: Beam-energy drifts were simulated by adjusting Linac's bending-magnet-current (BMC) followed by tuning the pulse-forming network and adjusting gun-current. PDD change of -0.6% and +1.2% were tested. Planar-dosimetry measurements were performed using an ionization-chamber-array in solid-water phantoms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046290/su-f-t-517-determining-the-tissue-equivalence-of-a-brass-mesh-bolus-in-a-reconstructed-chest-wall-irradiation
#7
E Shekel, D Epstein, D Levin
PURPOSE: To determine the tissue equivalence of a brass mesh bolus (RPD) in the setting of a reconstructed chest wall irradiation METHODS: We measured breast skin dose delivered by a tangential field plan on an anthropomorphic phantom using Mosfet and nanoDot (Landauer) dosimeters in five different locations on the breast. We also measured skin dose using no bolus, 5mm and 10 mm superflab bolus. In the Eclipse treatment planning system (Varian, Palo Alto, CA) we calculated skin dose for different bolus thicknesses, ranging from 0 to 10 mm, in order to evaluate which calculation best matches the brass mesh measurements, as the brass mesh cannot be simulated due to artefacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008860/basal-serum-neurokinin-b-level-can-be-used-to-differentiate-idiopathic-central-precocious-puberty-from-premature-thelarche-in-girls
#8
Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz
OBJECTIVE: The aim of the study is to investigate the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: The girls who presented with early breast development before the age of 8 years were evaluated. Basal and stimulated FSH, LH levels and basal neurokinin B and kisspeptin levels were measured. Patients who had peak LH > 5mIU/mL, and a bone age (BA) /chronological age (CA) ratio >1...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28008224/centrosome-a-promising-anti-cancer-target
#9
REVIEW
Yainyrette Rivera-Rivera, Harold I Saavedra
The centrosome, an organelle discovered >100 years ago, is the main microtubule-organizing center in mammalian organisms. The centrosome is composed of a pair of centrioles surrounded by the pericentriolar material (PMC) and plays a major role in the regulation of cell cycle transitions (G1-S, G2-M, and metaphase-anaphase), ensuring the normality of cell division. Hundreds of proteins found in the centrosome exert a variety of roles, including microtubule dynamics, nucleation, and kinetochore-microtubule attachments that allow correct chromosome alignment and segregation...
2016: Biologics: Targets & Therapy
https://www.readbyqxmd.com/read/27986470/anticancer-activity-and-tissue-distribution-of-platinum-ii-complex-with-lignin-derived-polymer-of-benzene-poly-carboxylic-acids
#10
Nikolay D Solovyev, Elena I Fedoros, Evgenii J Drobyshev, Natalya B Ivanenko, Sergey E Pigarev, Margarita L Tyndyk, Vladimir N Anisimov, Yury A Vilpan, Andrey V Panchenko
Platinum-containing antineoplastic agents with physiologically active ligands seem to be a promising direction in anticancer drug design. PDBA is a novel promising antineoplastic agent, containing polymer ligand of natural origin (international patent WO2013/143549 A1). Polymer ligand of PDBA has a highly functionalised polyphenolic backbone, which exerts its own pharmacological effect via immune modulation and regulation of gene expression. PDBA is a cis-diammineplatinum(II) complex, containing mono-deprotonated benzene-poly-carboxylic acids, derived from lignin, and hydroxyl group as O-donor ligands (approximate bulk formula C83H70N2O27Pt)...
November 27, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27983911/validity-of-osteoprotegerin-and-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-for-detection-of-bone-metastasis-in-breast-cancer
#11
Gamal Elfar, Mohamed Ebrahim, Nehal Elsherbiny, Laila Eissa
Osteoprotegerin (OPG) is a robust antiresorptive molecule that acts as a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL), the mediator of osteoclastogenesis. This study was designed to explore the possible role of serum OPG and RANKL in detecting bone metastasis in breast cancer and its interaction with clinicopathologic parameters. Serum levels of RANKL and OPG were estimated in 44 metastatic and 36 non-metastatic breast cancer patients using ELISA kits. Serum OPG levels were significantly reduced in patients with bony metastasis and correlated negatively with the number of bone lesions and CA 15-3 levels...
26, 2016: Oncology Research
https://www.readbyqxmd.com/read/27973439/down-regulation-of-ca-2-activated-k%C3%A2-%C2%BA-channel-kca1-1-in-human-breast-cancer-mda-mb-453-cells-treated-with-vitamin-d-receptor-agonists
#12
Anowara Khatun, Mayu Fujimoto, Hiroaki Kito, Satomi Niwa, Takayoshi Suzuki, Susumu Ohya
Vitamin D (VD) reduces the risk of breast cancer and improves disease prognoses. Potential VD analogs are being developed as therapeutic agents for breast cancer treatments. The large-conductance Ca(2+)-activated K⁺ channel KCa1.1 regulates intracellular Ca(2+) signaling pathways and is associated with high grade tumors and poor prognoses. In the present study, we examined the effects of treatments with VD receptor (VDR) agonists on the expression and activity of KCa1.1 in human breast cancer MDA-MB-453 cells using real-time PCR, Western blotting, flow cytometry, and voltage-sensitive dye imaging...
December 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27971930/the-patient-journey-after-a-diagnosis-of-early-locally-advanced-breast-ca-in-greece-and-choice-of-provider
#13
E Karampli, V Tsiantou, A Skroumpelos, K Mylona, K Athanasakis, D Zavras, E Pavi, J Kyriopoulos
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27965034/the-ins-and-outs-of-calcium-signalling-in-lactation-and-involution-implications-for-breast-cancer-treatment
#14
Felicity M Davis
The mammary epithelium is highly responsive to hormonal and non-hormonal signalling cues for physiological growth, function and tissue remodelling. Whilst steroid hormones freely diffuse across the cell membrane to bind to intracellular hormone receptors, cell-impermeable ligands, including many peptide hormones, growth factors and cytokines, bind to receptors on the plasma membrane and relay their message via the specific activation of intracellular signal transduction pathways. A signalling pathway that is indispensable for decoding many extracellular signals into cellular responses is calcium (Ca(2+))...
December 10, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27937091/personal-genomic-testing-for-cancer-risk-results-from-the-impact-of-personal-genomics-study
#15
Stacy W Gray, Sarah E Gollust, Deanna Alexis Carere, Clara A Chen, Angel Cronin, Sarah S Kalia, Huma Q Rana, Mack T Ruffin, Catharine Wang, J Scott Roberts, Robert C Green
Purpose Significant concerns exist regarding the potential for unwarranted behavior changes and the overuse of health care resources in response to direct-to-consumer personal genomic testing (PGT). However, little is known about customers' behaviors after PGT. Methods Longitudinal surveys were given to new customers of 23andMe (Mountain View, CA) and Pathway Genomics (San Diego, CA). Survey data were linked to individual-level PGT results through a secure data transfer process. Results Of the 1,042 customers who completed baseline and 6-month surveys (response rate, 71...
December 12, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27930560/risk-of-secondary-cancers-in-women-with-breast-cancer-and-the-influence-of-radiotherapy-a-national-cohort-study-in-taiwan
#16
Cheng-Yao Lin, Sih-Hao Chen, Chien-Cheng Huang, Shih-Feng Weng, Song-Tay Lee, How-Ran Guo, Shu-Chun Kuo, Shih-Bin Su
Breast cancer is the most common cancer in women worldwide; thus, the prolongation of survival, and the incidence and risk factors, including radiotherapy, for developing secondary malignancies are important. We compared the incidence of secondary and new primary cancers in women with breast cancer (CA) and well-matched for age, geographic region, and monthly income cancer-free controls (CA). The risk for secondary cancers with and without radiotherapy was also compared in CA women. We enrolled 2422 CA patients and CA 12,110 controls...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27925035/insulin-like-growth-factor-1-gene-polymorphism-and-breast-cancer-risk
#17
Danylo R Costa-Silva, Maria DA Conceição Barros-Oliveira, Rafael S Borges, Cléciton B Tavares, Umbelina S Borges, Francisco A Alves-Ribeiro, Vladimir C Silva, Benedito B DA Silva
Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk...
October 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27923573/the-impacts-of-selective-logging-and-clear-cutting-on-woody-plant-diversity-after-40years-of-natural-recovery-in-a-tropical-montane-rain-forest-south-china
#18
Yi Ding, Runguo Zang, Xinghui Lu, Jihong Huang
Historically, clear-cutting and selective logging have been the commercial logging practices. However, the effect of these pervasive timber extraction methods on biodiversity in tropical forests is still poorly understood. In this study, we compared abiotic factors, species diversity, community composition, and structure between ca. 40-year-old clear-cut (MCC); ca. 40-year-old selectively logged (MSL); and tropical old growth montane rain forests (MOG) on Hainan Island, China. Results showed that there were a large number of trees with a diameter at breast height (DBH) <30cm in the two logged forests...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27921280/ph-responsive-triblock-copolymeric-micelles-decorated-with-a-cell-penetrating-peptide-provide-efficient-doxorubicin-delivery
#19
Khen Eng Ng, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Muhammad Wahab Amjad, Adeel Masood Butt, Prashant Kesharwani, Arun K Iyer
This study developed novel triblock pH-responsive polymeric micelles (PMs) using cholic acid-polyethyleneimine-poly-L-arginine (CA-PEI-pArg) copolymers. PEI provided pH sensitivity, while the hydrophilic cell-penetrating pArg peptide promoted cellular PM internalization. The copolymers self-assembled into PMs in aqueous solution at above the critical micelle concentration (2.98 × 10(-7) M) and encapsulated doxorubicin in the core region, with a 34.2% (w/w) entrapment efficiency. PMs showed pH-dependent swelling, increasing in size by almost sevenfold from pH 7...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27919655/novel-carbazole-sulfonamide-derivatives-of-antitumor-agent-synthesis-antiproliferative-activity-and-aqueous-solubility
#20
Lianqi Sun, Yanbin Wu, Yonghua Liu, Xiaofang Chen, Laixing Hu
The current optimization of IG-105 (3) on the carbazole-ring provided a series of new carbazole sulfonamides derivatives 13a-13m. All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of 3 versus HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five (13b, 13g, 13j, 13k and 13l) were found to give IC50 values against the four cell lines comparable to those for 3...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
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