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https://www.readbyqxmd.com/read/27930560/risk-of-secondary-cancers-in-women-with-breast-cancer-and-the-influence-of-radiotherapy-a-national-cohort-study-in-taiwan
#1
Cheng-Yao Lin, Sih-Hao Chen, Chien-Cheng Huang, Shih-Feng Weng, Song-Tay Lee, How-Ran Guo, Shu-Chun Kuo, Shih-Bin Su
Breast cancer is the most common cancer in women worldwide; thus, the prolongation of survival, and the incidence and risk factors, including radiotherapy, for developing secondary malignancies are important. We compared the incidence of secondary and new primary cancers in women with breast cancer (CA) and well-matched for age, geographic region, and monthly income cancer-free controls (CA). The risk for secondary cancers with and without radiotherapy was also compared in CA women. We enrolled 2422 CA patients and CA 12,110 controls...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27925035/insulin-like-growth-factor-1-gene-polymorphism-and-breast-cancer-risk
#2
Danylo R Costa-Silva, Maria DA Conceição Barros-Oliveira, Rafael S Borges, Cléciton B Tavares, Umbelina S Borges, Francisco A Alves-Ribeiro, Vladimir C Silva, Benedito B DA Silva
Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27923573/the-impacts-of-selective-logging-and-clear-cutting-on-woody-plant-diversity-after-40years-of-natural-recovery-in-a-tropical-montane-rain-forest-south-china
#3
Yi Ding, Runguo Zang, Xinghui Lu, Jihong Huang
Historically, clear-cutting and selective logging have been the commercial logging practices. However, the effect of these pervasive timber extraction methods on biodiversity in tropical forests is still poorly understood. In this study, we compared abiotic factors, species diversity, community composition, and structure between ca. 40-year-old clear-cut (MCC); ca. 40-year-old selectively logged (MSL); and tropical old growth montane rain forests (MOG) on Hainan Island, China. Results showed that there were a large number of trees with a diameter at breast height (DBH) <30cm in the two logged forests...
December 3, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27921280/ph-responsive-triblock-copolymeric-micelles-decorated-with-a-cell-penetrating-peptide-provide-efficient-doxorubicin-delivery
#4
Khen Eng Ng, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Muhammad Wahab Amjad, Adeel Masood Butt, Prashant Kesharwani, Arun K Iyer
This study developed novel triblock pH-responsive polymeric micelles (PMs) using cholic acid-polyethyleneimine-poly-L-arginine (CA-PEI-pArg) copolymers. PEI provided pH sensitivity, while the hydrophilic cell-penetrating pArg peptide promoted cellular PM internalization. The copolymers self-assembled into PMs in aqueous solution at above the critical micelle concentration (2.98 × 10(-7) M) and encapsulated doxorubicin in the core region, with a 34.2% (w/w) entrapment efficiency. PMs showed pH-dependent swelling, increasing in size by almost sevenfold from pH 7...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27919655/novel-carbazole-sulfonamide-derivatives-of-antitumor-agent-synthesis-antiproliferative-activity-and-aqueous-solubility
#5
Lianqi Sun, Yanbin Wu, Yonghua Liu, Xiaofang Chen, Laixing Hu
The current optimization of IG-105 (3) on the carbazole-ring provided a series of new carbazole sulfonamides derivatives 13a-13m. All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of 3 versus HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five (13b, 13g, 13j, 13k and 13l) were found to give IC50 values against the four cell lines comparable to those for 3...
November 25, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27919267/targeted-drug-delivery-of-near-ir-fluorescent-doxorubicin-conjugated-poly-ethylene-glycol-bisphosphonate-nanoparticles-for-diagnosis-and-therapy-of-primary-and-metastatic-bone-cancer-in-a-mouse-model
#6
S Rudnick-Glick, E Corem-Salkmon, I Grinberg, S Margel
BACKGROUND: Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects are associated with chemotherapy due to use of high dosage and nonspecific uptake. Bisphosphonates have a strong affinity to Ca(2+) ions and are widely used in the treatment of bone disorders. RESULTS: We have engineered a unique biodegradable bisphosphonate nanoparticle (NPs) bearing two functional surface groups: (1) primary amine groups for covalent attachment of a dye/drug (e...
December 5, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27894917/incidence-of-breast-implant-rupture-in-a-12-year-retrospective-cohort-evidence-of-quality-discrepancy-depending-on-the-range
#7
Frédéric Seigle-Murandi, François Lefebvre, Catherine Bruant-Rodier, Frédéric Bodin
BACKGROUND & OBJECTIVE: The majority of studies assessing the rupture rate of breast implants were performed by the breast implant manufacturing industry with questionable independence. After repetitive removals of ruptured implants from the same model, our team decided to assess the rupture rate and the estimated risk thereof for most of the silicone gel-filled implants we have used since they regained market approval in France in 2001. METHODS: Our study is a retrospective cohort of 809 patients operated in our University Hospital from 2001 to 2013 for cosmetic or reconstructive goals...
November 10, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27894589/discovery-and-preclinical-evaluation-of-7-benzyl-n-substituted-pyrrolo-3-2-d-pyrimidin-4-amines-as-single-agents-with-microtubule-targeting-effects-along-with-triple-acting-angiokinase-inhibition-as-antitumor-agents
#8
Roheeth Kumar Pavana, Shruti Choudhary, Anja Bastian, Michael A Ihnat, Ruoli Bai, Ernest Hamel, Aleem Gangjee
The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical combinations of AA with microtubule targeting agents (MTAs) have been particularly successful. The discovery, synthesis and biological evaluations of a series of 7-benzyl-N-substituted-pyrrolo[3,2-d]pyrimidin-4-amines are reported. Novel compounds which inhibit proangiogenic receptor tyrosine kinases (RTKs) including vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β) and epidermal growth factor receptor (EGFR), along with microtubule targeting in single molecules are described...
November 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27880919/activation-of-g-protein-coupled-receptor-30-by-thiodiphenol-promotes-proliferation-of-estrogen-receptor-%C3%AE-positive-breast-cancer-cells
#9
Bingli Lei, Wei Peng, Gang Xu, Minghong Wu, Yu Wen, Jie Xu, Zhiqiang Yu, Yipei Wang
Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERα) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. 4,4'-thiodiphenol (TDP) as one of BPA derivatives exhibits more potent estrogenic activity than BPA does. However, comparatively little is known about the ways in which TDP interferes with these signaling pathways and produces cell biological changes...
November 20, 2016: Chemosphere
https://www.readbyqxmd.com/read/27875276/cancer-cells-become-less-deformable-and-more-invasive-with-activation-of-%C3%AE-adrenergic-signaling
#10
Tae-Hyung Kim, Navjot Kaur Gill, Kendra D Nyberg, Angelyn V Nguyen, Sophia V Hohlbauch, Nicholas A Geisse, Cameron J Nowell, Erica K Sloan, Amy C Rowat
Invasion by cancer cells is a critical step in metastasis. An oversimplified view in the literature is that cancer cells become more deformable as they become more invasive. β-adrenergic receptor (βAR) signaling drives invasion and metastasis, but the effects on cell deformability are not known. Here we show that activation of β-adrenergic signaling by βAR agonists reduces the deformability of highly metastatic human breast cancer cells, and that these stiffer cells are more invasive in vitro We find that βAR activation also reduces the deformability of ovarian, prostate, melanoma, and leukemia cells...
November 14, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27862646/a-randomized-pilot-trial-of-a-positive-affect-skills-intervention-lilac-for-women-with-metastatic-breast-cancer
#11
Elaine O Cheung, Michael A Cohn, Laura B Dunn, Michelle E Melisko, Stefana Morgan, Frank J Penedo, John M Salsman, Dianne M Shumay, Judith T Moskowitz
OBJECTIVES: We conducted a randomized pilot trial to examine the feasibility, acceptability and preliminary efficacy of a 5-week positive affect skills intervention (LILAC: Lessons in Linking Affect and Coping) for women with metastatic breast cancer. Additionally, we examined whether online delivery of the intervention would offer comparable benefits as in-person delivery. METHODS: Women with metastatic breast cancer (N = 39) were randomized to an in-person intervention, online intervention, or in-person attention-matched control...
November 16, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27861384/trends-of-triple-negative-breast-cancer-research-2007-2015-a-bibliometric-study
#12
Yiran Wang, Xiao Zhai, Chuan Liu, Ning Wang, Yajie Wang
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. METHODS: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Prism Software Inc...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856238/evaluation-of-known-and-novel-inhibitors-of-orai1-mediated-store-operated-ca-2-entry-in-mda-mb-231-breast-cancer-cells-using-a-fluorescence-imaging-plate-reader-assay
#13
Iman Azimi, Jack U Flanagan, Ralph J Stevenson, Marco Inserra, Irina Vetter, Gregory R Monteith, William A Denny
The Orai1 Ca(2+) permeable ion channel is an important component of store operated Ca(2+) entry (SOCE) in cells. It's over-expression in basal molecular subtype breast cancers has been linked with poor prognosis, making it a potential target for drug development. We pharmacologically characterised a number of reported inhibitors of SOCE in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader (FLIPR) assay, and show that the rank order of their potencies in this assay is the same as those reported in a wide range of published assays...
November 7, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27828067/laser-induced-breakdown-spectroscopy-and-acoustic-response-techniques-to-discriminate-healthy-and-cancerous-breast-tissues
#14
Fatemeh Ghasemi, Parviz Parvin, Najme Sadat Hosseini Motlagh, Ahmad Amjadi, Shahriar Abachi
Laser induced breakdown spectroscopy and subsequent acoustic response during microplasma formation are employed to identify cancerous human breast tissues. The characteristic optical emissions identify Ca, Na, and Mg rich species in cancerous tissues compared to those of healthy ones. Furthermore, we show that the characteristic parameters of the microplasma, generated on the unhealthy tissues, are elevated. We report higher decibel audio signals emanating from laser induced microplasma and a subsequent audio blueshift for malignant tissues...
October 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27813580/breeding-of-acrocomia-aculeata-using-genetic-diversity-parameters-and-correlations-to-select-accessions-based-on-vegetative-phenological-and-reproductive-characteristics
#15
S M Coser, S Y Motoike, T R Corrêa, T P Pires, M D V Resende
Macaw palm (Acrocomia aculeata) is a promising species for use in biofuel production, and establishing breeding programs is important for the development of commercial plantations. The aim of the present study was to analyze genetic diversity, verify correlations between traits, estimate genetic parameters, and select different accessions of A. aculeata in the Macaw Palm Germplasm Bank located in Universidade Federal de Viçosa, to develop a breeding program for this species. Accessions were selected based on precocity (PREC), total spathe (TS), diameter at breast height (DBH), height of the first spathe (HFS), and canopy area (CA)...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27807828/anxa7-gtpase-as-tumor-suppressor-mechanisms-and-therapeutic-opportunities
#16
Ximena Leighton, Ofer Eidelman, Catherine Jozwik, Harvey B Pollard, Meera Srivastava
Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity at 10q, are commonly observed in most human tumors, including prostate, breast, and kidney cancers. The ANXA7-GTPase is a tumor suppressor, which is frequently inactivated by genomic alterations at 10q21. In the last few years, considerable amounts of data have accumulated describing inactivation of ANXA7-GTPase in a variety of human malignancies and demonstrating the tumor suppressor potential of ANXA7-GTPase. ANXA7-GTPase contains a calcium binding domain that classifies it as a member of the annexin family...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27775427/plasma-levels-and-diagnostic-utility-of-vegf-mmp-2-and-timp-2-in-the-diagnostics-of-breast-cancer-patients
#17
Sławomir Ławicki, Monika Zajkowska, Edyta Katarzyna Głażewska, Grażyna Ewa Będkowska, Maciej Szmitkowski
OBJECTIVE: We investigated plasma levels and diagnostic utility of VEGF, MMP-2 and TIMP-2 in comparison to CA 15-3. METHODS: Plasma levels of tested parameters were determined using ELISA while CA 15-3 with CMIA. RESULTS: The plasma levels of VEGF, TIMP-2 showed significantly higher than CA 15-3 values of the diagnostic sensitivity, the predictive values of positive and negative test results (PPV, NPV) and the area under the ROC curve (AUC) in early stages of breast cancer...
October 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27761070/phytochemicals-and-cytotoxicity-of-launaea-procumbens-on-human-cancer-cell-lines
#18
Preeti Rawat, Lokesh M Saroj, Anil Kumar, Tryambak D Singh, S K Tewari, Mahesh Pal
BACKGROUND: The plant Launaea procumbens belongs to the family Asteraceae and traditionally used in the treatment rheumatism, kidney, liver dysfunctions and eye diseases. In the present study Phytochemical analysis and fractions of methanolic extract of L. procumbens leaves were tested in vitro for their cytotoxicity. OBJECTIVES: Phytochemical analysis and cytotoxic activity of methanolic extract and fractions of Launaea procumbens against four cancer cell lines K562, HeLa, MIA-Pa-Ca-2 and MCF-2 by SRB assay...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27742744/a-novel-l-fucose-binding-lectin-from-fenneropenaeus-indicus-induced-cytotoxicity-in-breast-cancer-cells
#19
Biji Chatterjee, Krishna Ghosh, Nitin Yadav, Santosh R Kanade
Lectins are omnipresent in almost all life forms, being the proteins which specifically bind to carbohydrate moieties on the cell surface; they have been explored for their anti-tumour activities. In this study, we purified a fucose specific-lectin (IFL) from Fenneropenaeus indicus hemolymph using fucose-affinity column and characterized for its hemagglutination activity, carbohydrate specificity, dependency on cations and cytotoxicity against cancer cells. The lectin showed non-specificity against human erythrocytes...
October 13, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/27733047/paradox-ca-15-3-increase-in-metastatic-breast-cancer-patients-treated-with-everolimus-a-change-of-paradigm-in-a-case-series
#20
Armando Orlandi, Carmela Di Dio, Maria Alessandra Calegari, Carlo Barone
Everolimus and exemestane represent a standard treatment for metastatic hormone receptor-positive/HER2-negative advanced breast cancer resistant to aromatase inhibitors. CA 15-3 serum levels detect soluble forms of MUC-1, a transmembrane oncoprotein aberrantly overexpressed in breast cancers. In clinical practice, CA 15-3 may be used to indicate treatment failure in the absence of readily measurable disease during cytotoxic therapy. In the targeted therapy era, it is important to note that the C-terminal subunit of MUC-1 interacts with PI3K/AKT pathway, inducting cell growth...
October 13, 2016: Biomarkers in Medicine
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