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https://www.readbyqxmd.com/read/28210929/effect-of-boswellia-serrata-resin-supplementation-on-basic-chemical-and-mineral-element-composition-in-the-muscles-and-liver-of-broiler-chickens
#1
A R M Al-Yasiry, B Kiczorowska, W Samolińska
Supplementation of broiler chicken diets with resin rich in bioactive components, such as different boswellic acids, could improve productivity, chemical composition, and nutritive value of produced meat. The aim of the study was to assess the effect of different levels of Boswellia serrata (BSR) supplementation in broiler chicken diet on the basic chemical composition and the Ca, P, Mg, Fe, Zn, and Cu contents in the breast and drumstick muscles and liver. The analyses involved 200 Ross 308 chickens. The broiler chickens were fed with diets containing 0 (BSR0), 1...
February 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28203552/a-novel-panel-of-serum-mir-21-mir-155-mir-365-as-a-potential-diagnostic-biomarker-for-breast-cancer
#2
Ji-Guang Han, Yong-Dong Jiang, Chun-Hui Zhang, Yan-Mei Yang, Da Pang, Yan-Ni Song, Guo-Qiang Zhang
PURPOSE: Insufficient sensitivity and specificity prevent the use of most existing biomarkers for early detection of breast cancer. Recently, it was reported that serum microRNAs (miRNAs) may be potential biomarkers in many cancer diseases. In this study, we investigated whether serum levels of 5 miRNAs including miR-21, miR-125b, miR-145, miR-155, and miR-365 could discriminate breast cancer patients and healthy controls. METHODS: Serum levels of miRNAs were measured by using quantitative real-time polymerase chain reaction in 99 breast cancer patients and 21 healthy controls...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28192161/enzymatic-cleavage-of-myoferlin-releases-a-dual-c2-domain-module-linked-to-erk-signalling
#3
Ann-Katrin Piper, Samuel E Ross, Gregory M Redpath, Frances A Lemckert, Natalie Woolger, Adam Bournazos, Peter A Greer, Roger B Sutton, Sandra T Cooper
Myoferlin and dysferlin are closely related members of the ferlin family of Ca(2+)-regulated vesicle fusion proteins. Dysferlin is proposed to play a role in Ca(2+)-triggered vesicle fusion during membrane repair. Myoferlin regulates endocytosis, recycling of growth factor receptors and adhesion proteins, and is linked to the metastatic potential of cancer cells. Our previous studies establish that dysferlin is cleaved by calpains during membrane injury, with the cleavage motif encoded by alternately-spliced exon 40a...
February 10, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28179964/prognostic-impact-of-the-tumor-marker-ca-15-3-in-patients-with-breast-cancer-and-bone-metastases-treated-with-palliative-radiotherapy
#4
Carsten Nieder, Astrid Dalhaug, Ellinor Haukland, Bard Mannsaker, Adam Pawinski
BACKGROUND: The aim of the study was to explore the prognostic impact of different abnormal blood tests and the tumor marker CA 15-3 as well as established parameters such as disease extent and receptor status in patients with bone metastases from breast cancer who received palliative radiotherapy in addition to contemporary systemic treatment. METHODS: This was a retrospective uni- and multivariate analysis of 118 female patients treated in the time period from 2007 to 2014 (median follow-up 28 months)...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28179115/chemical-composition-of-the-essential-oils-and-extracts-of-achillea-species-and-their-biological-activities-a-review
#5
REVIEW
Majid Mohammadhosseini, Satyajit D Sarker, Abolfazl Akbarzadeh
ETHNOPHARMACOLOGICAL RELEVANCE: The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they heve been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines...
February 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28177558/tmem16a-ano1-suppression-improves-response-to-antibody-mediated-targeted-therapy-of-egfr-and-her2-erbb2
#6
Sucheta Kulkarni, Anke Bill, Neal R Godse, Nayel I Khan, Jason I Kass, Kevin Steehler, Carolyn Kemp, Kara Davis, Carol A Bertrand, Avani R Vyas, Douglas E Holt, Jennifer R Grandis, L Alex Gaither, Umamaheswar Duvvuri
TMEM16A, a Ca(2+) -activated Cl(-) channel, contributes to tumor growth in breast cancer and head and neck squamous cell carcinoma (HNSCC). Here, we investigated whether TMEM16A influences the response to EGFR/HER family-targeting biological therapies. Inhibition of TMEM16A Cl(-) channel activity in breast cancer cells with HER2 amplification induced a loss of viability. Cells resistant to trastuzumab, a monoclonal antibody targeting HER2, showed an increase in TMEM16A expression and heightened sensitivity to Cl(-) channel inhibition...
February 8, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28170086/cancer-screening-in-the-united-states-2017-a-review-of-current-american-cancer-society-guidelines-and-current-issues-in-cancer-screening
#7
Robert A Smith, Kimberly S Andrews, Durado Brooks, Stacey A Fedewa, Deana Manassaram-Baptiste, Debbie Saslow, Otis W Brawley, Richard C Wender
Answer questions and earn CME/CNE Each year, the American Cancer Society publishes a summary of its guidelines for early cancer detection, data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, the authors summarize current American Cancer Society cancer screening guidelines, describe an update of their guideline for using human papillomavirus vaccination for cancer prevention, describe updates in US Preventive Services Task Force recommendations for breast and colorectal cancer screening, discuss interim findings from the UK Collaborative Trial on Ovarian Cancer Screening, and provide the latest data on utilization of cancer screening from the National Health Interview Survey...
February 7, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28168160/insights-into-biochemical-alteration-in-cancer-associated-fibroblasts-by-using-novel-correlative-spectroscopy
#8
Saroj Kumar, Xia Liu, Ferenc Borondics, Qunfeng Xiao, Renfei Feng, Erik Goormaghtigh, Fredrik Nikolajeff
The microenvironment of a tumor changes chemically and morphologically during cancer progression. Cancer-stimulated fibroblasts promote tumor growth, however, the mechanism of the transition to a cancer-stimulated fibroblast remains elusive. Here, the multi-modal spectroscopic methods Fourier transform infrared imaging (FTIRI), X-ray absorption spectroscopy (XAS) and X-ray fluorescence imaging (XFI) are used to characterize molecular and atomic alterations that occur in cancer-stimulated fibroblasts. In addition to chemical changes in lipids (olefinic and acyl chain) and protein aggregation observed with FTIRI, a new infrared biomarker for oxidative stress in stimulated fibroblasts is reported...
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28164586/plasma-levels-and-diagnostic-utility-of-m-csf-mmp-2-and-its-inhibitor-timp-2-in-the-diagnostics-of-breast-cancer-patients
#9
Monika Zajkowska, Maciej Szmitkowski
BACKGROUND: M-CSF, MMP-2 and its inhibitor TIMP-2 may play a role in the pathogenesis and proliferation of breast cancer (BC). In this paper, plasma levels and the diagnostic utility of these parameters were investigated in comparison to CA 15-3 in patients with BC and in relation to the control groups: patients with benign breast tumor and healthy subjects. METHODS: Plasma levels of the tested parameters were determined using immunoenzyme assay (ELISA) and CA 15-3 with a chemiluminescence method (CMIA)...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28156483/impact-of-financial-burden-on-information-and-opportunity-for-cancer-ca-patients-pts-participation-par-in-clinical-trials-cts
#10
Dana Dornsife
: 166 Background: The degree to which cancer caused financial problems may influence ca pts par in cts and negatively impact quality of life (QoL). Financial burden of cts par, may include finding an appropriate trial, traveling to the trial site, paying for travel, lodging and some medical expenses. The Lazarex Cancer Foundation (LCF) was founded in 2006 with mission to improve care, giving hope, dignity, and life to advanced ca pts by providing assistance with options and costs to cts par, community outreach, and education...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152839/development-of-a-radiation-oncology-specific-prospective-data-registry-for-clinical-research-and-quality-improvement-a-clinical-workflow-based-solution
#11
Pin-Chieh Wang, Darlene Verittupong, Weber Shao, Susan Ann McCloskey, Vincent Basehart, Michael L Steinberg, Patrick Kupelian
: 197 Background: The computerized 'paperless' medical recording system has transformed the modern health information system and serves as an idea platform for cancer registry development, particularly in a specialty like radiation oncology, where technological advances generate unprecedented amounts of data. METHODS: From May 2011 to May 2015, physicians prospectively inputted data on patients seen during consultation in the Department of Radiation Oncology at UCLA...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152829/prevalence-and-predictors-of-second-opinions-from-medical-oncologists-for-early-stage-breast-cancer-results-from-the-icancare-study
#12
Christopher Ryan Friese, Irina Bondarenko, Reshma Jagsi, Steven J Katz
: 185 Background: A second medical oncology opinion (SMO) may facilitate chemotherapy decision-making. However, little is known about the interplay between SMOs, treatment decision-making and chemotherapy use. METHODS: We surveyed women newly diagnosed with early-stage invasive breast cancer and treated in 2013-2014 (response rate 70%), accrued approximately 3 months after surgery through 2 population-based SEER registries (Georgia and Los Angeles), about their experiences with medical oncologists, decision-making, and chemotherapy use...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150875/atp2a3-gene-as-an-important-player-for-resveratrol-anticancer-activity-in-breast-cancer-cells
#13
Eduardo Izquierdo-Torres, Gabriela Rodríguez, Iván Meneses-Morales, Angel Zarain-Herzberg
The Ca(2+) -ATPases from the Sarco/endoplasmic reticulum (SERCA) are fundamental for maintaining intracellular [Ca(2+) ] homeostasis by pumping Ca(2+) into the endoplasmic reticulum (ER) of eukaryotic cells. SERCA enzymes are encoded by three different genes (ATP2A1-3), whose expression occurs in a tissue and development stage-specific manner. It has been reported alterations in the expression of SERCA2 and SERCA3 pumps in different types of cancer: oral, lung, colon, stomach, central nervous system, thyroid, breast, and prostate...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28145580/sp-2-iminosugar-%C3%AE-glucosidase-inhibitor-1-c-octyl-2-oxa-3-oxocastanospermine-specifically-affected-breast-cancer-cell-migration-through-stim1-%C3%AE-1-integrin-and-fak-signaling-pathways
#14
Nahla Gueder, Ghada Allan, Marie-Sophie Telliez, Frédéric Hague, José M Garcia Fernandez, Elena M Sanchez-Fernandez, Carmen Ortiz-Mellet, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Aberrant glycosylation changes on many glycoproteins are often related to cancer progression and metastasis. sp(2) -Iminosugar-type castanospermine analogues, inhibitors of α-glucosidases, have been reported to exhibit antitumor activity. However, their effects on cell migration and the underlying molecular mechanism are not fully understood. Here, we investigated the effect of the pseudo- C-octyl glycoside 2-oxa-3-oxocastanospermine derivatives (CO-OCS) on breast cancer cells (MCF-7 and MDA-MB-231 cells), and MCF-10A mammary normal cell lines...
February 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28145547/garcinol-sensitizes-breast-cancer-cells-to-taxol-through-the-suppression-of-caspase-3-ipla2-and-nf-%C3%AE%C2%BAb-twist1-signaling-pathways-in-a-mouse-4t1-breast-tumor-model
#15
Shih-Hsin Tu, Yi-Shiou Chiou, Nagabhushanam Kalyanam, Chi-Tang Ho, Li-Ching Chen, Min-Hsiung Pan
Breast cancer is a significant threat to women's health and has high incidence and mortality. Metastasis in breast cancer patients is a major cause of cancer deaths among women worldwide. Clinical experience suggests that patients with metastatic triple-negative breast cancer (TNBC) relapse quickly and often have chemotherapy resistance. Taxol (paclitaxel) is an effective chemotherapeutic agent for treating metastatic breast cancer, but Taxol at high doses can cause adverse effects and recurrent resistance...
February 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28133535/3d-porous-chitosan-alginate-scaffolds-promote-proliferation-and-enrichment-of-cancer-stem-like-cells
#16
Stephen J Florczyk, Forrest M Kievit, Kui Wang, Ariane E Erickson, Richard G Ellenbogen, Miqin Zhang
Cancer stem cells are increasingly becoming a primary target for new cancer treatment development. The ability to study their transient behavior in vitro will provide the opportunity for high-throughput testing of more effective therapies. We have previously demonstrated the use of 3D porous chitosan-alginate (CA) scaffolds to promote cancer stem-like cell (CSC) proliferation and enrichment in glioblastoma. Here we use 3D porous CA scaffolds to promote cancer stem-like cell enrichment in cell lines from prostate, liver, and breast cancers, and investigate the proliferation, morphology, and gene expressions of cells cultured in CA scaffolds as compared to 2D controls...
October 14, 2016: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28116092/teleocidin-a2-inhibits-human-proteinase-activated-receptor-2-signaling-in-tumor-cells
#17
Sonja Stahn, Lisa Thelen, Ina-Maria Albrecht, Jens Bitzer, Thomas Henkel, Nicole Elisabeth Teusch
Enhanced expression of the proteinase-activated receptor 2 (PAR2) is linked to cell proliferation and migration in many cancer cell types. The role of PAR2 in cancer progression strongly illustrates the need for PAR2-inhibiting compounds. However, to date, potent and selective PAR2 antagonists have not been reported. The natural product teleocidin A2 was characterized against PAR2-activating peptide SLIGKV-NH 2, and trypsin-induced PAR2-dependent intracellular Ca(2+) mobilization in tumor and in primary endothelial or epithelial cells...
August 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28114279/the-sigmar1-chaperone-drives-breast-and-colorectal-cancer-cell-migration-by-tuning-sk3-dependent-ca-2-homeostasis
#18
M Gueguinou, D Crottès, A Chantôme, R Rapetti-Mauss, M Potier-Cartereau, L Clarysse, A Girault, Y Fourbon, P Jézéquel, C Guérin-Charbonnel, G Fromont, P Martin, B Pellissier, R Schiappa, E Chamorey, O Mignen, A Uguen, F Borgese, C Vandier, O Soriani
The remodeling of calcium homeostasis contributes to the cancer hallmarks and the molecular mechanisms involved in calcium channel regulation in tumors remain to be characterized. Here, we report that SigmaR1, a stress-activated chaperone, is required to increase calcium influx by triggering the coupling between SK3, a Ca(2+)-activated K(+) channel (KCNN3) and the voltage-independent calcium channel Orai1. We show that SigmaR1 physically binds SK3 in BC cells. Inhibition of SigmaR1 activity, either by molecular silencing or by the use of sigma ligand (igmesine), decreased SK3 current and Ca(2+) entry in breast cancer (BC) and colorectal cancer (CRC) cells...
January 23, 2017: Oncogene
https://www.readbyqxmd.com/read/28097781/an-analysis-of-oncotype-dx-recurrence-scores-and-clinicopathologic-characteristics-in-invasive-lobular-breast-cancer
#19
Jesse L Felts, Junjia Zhu, Bing Han, Stanley J Smith, Cristina I Truica
The Oncotype DX breast cancer assay (Genomic Health, Redwood City, CA) is increasingly being used to guide treatment decisions for patients with early stage, hormone-positive, Her-2-negative breast cancer. The utility of the Oncotype DX in decision making for treatment of invasive lobular carcinoma (ILC) has not been investigated as the results reported by Genomic Health are largely in a population with invasive ductal carcinoma (IDC). The authors hypothesized that the Oncotype DX recurrence score (RS) distribution for ILC is different than that for IDC...
January 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/28092099/calmodulin-binding-to-death-receptor-5-mediated-death-inducing-signaling-complex-in-breast-cancer-cells
#20
Romone M Fancy, Harrison Kim, Tong Zhou, Kurt R Zinn, Donald J Buchsbaum, Yuhua Song
Activation of death receptor-5 (DR5) leads to the formation of death inducing signaling complex (DISC) for apoptotic signaling. TRA-8, a DR5 specific agonistic antibody, has demonstrated significant cytotoxic activity in vitro and in vivo without inducing hepatotoxicity. Calmodulin (CaM) that is overexpressed in breast cancer plays a critical role in regulating DR5-mediated apoptosis. However, the mechanism of CaM in regulating DR5-mediated apoptotic signaling remains unknown. In this study, we characterized CaM binding to DR5-mediated DISC for apoptosis in TRA-8 sensitive breast cancer cell lines using co-immunoprecipitation, fluorescence microscopic imaging, caspase signaling analysis and cell viability assay...
January 16, 2017: Journal of Cellular Biochemistry
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