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https://www.readbyqxmd.com/read/29788166/combined-pathologic-genomic-algorithm-for-early-stage-breast-cancer-improves-cost-effective-use-of-the-21-gene-recurrence-score-assay
#1
M M Gage, W C Mylander, M Rosman, T Fujii, F Le Du, A Raghavendra, A K Sinha, J R Espinosa Fernandez, A James, N T Ueno, L Tafra, R S Jackson
Background: The 21-gene recurrence score (RS) (Oncotype DX®; Genomic Health, Redwood City, CA) partitions hormone receptor positive, node negative breast cancers into three risk groups for recurrence. The Anne Arundel Medical Center (AAMC) model has previously been shown to accurately predict RS risk categories using standard pathology data. A pathologic-genomic (P-G) algorithm then is presented using the AAMC model and reserving the RS assay only for AAMC intermediate-risk patients...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29783106/prediction-of-the-combined-effects-of-multiple-estrogenic-chemicals-on-mcf-7-human-breast-cancer-cells-and-a-preliminary-molecular-exploration-of-the-estrogenic-proliferative-effects-and-related-gene-expression
#2
Shengwu Yuan, Chao Huang, Xiaoya Ji, Mei Ma, Kaifeng Rao, Zijian Wang
The environmental risks of environmental estrogens (EEs) are often assessed via the same mode of action in the concentration addition (CA) model, neglecting the complex combined mechanisms at the genetic level. In this study, the cell proliferation effects of estrone, 17α-ethinylestradiol, 17β-estradiol, estriol, diethylstilbestrol, estradiol valerate, bisphenol A, 4-tert-octylphenol and 4-nonylphenol were determined individually using the CCK-8 method, and the proliferation effects of a multicomponent mixture of estrogenic chemicals mixed at equipotent concentrations using a fixed-ratio design were studied using estrogen-sensitive MCF-7 cells...
May 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29776832/an-sar-study-of-hydroxy-trifluoromethylpyrazolines-as-inhibitors-of-orai1-mediated-store-operated-ca-2-entry-in-mda-mb-231-breast-cancer-cells-using-a-convenient-fluorescence-imaging-plate-reader-assay
#3
Ralph J Stevenson, Iman Azimi, Jack U Flanagan, Marco Inserra, Irina Vetter, Gregory R Monteith, William A Denny
The proteins Orai1 and STIM1 control store-operated Ca2+ entry (SOCE) into cells. SOCE is important for migration, invasion and metastasis of MDA-MB-231 human triple negative breast cancer (TNBC) cells and has been proposed as a target for cancer drug discovery. Two hit compounds from a medium throughput screen, displayed encouraging inhibition of SOCE in MDA-MB-231 cells, as measured by a Fluorescence Imaging Plate Reader (FLIPR) Ca2+ assay. Following NMR spectroscopic analysis of these hits and reassignment of their structures as 5-hydroxy-5-trifluoromethylpyrazolines, a series of analogues was prepared via thermal condensation reactions between substituted acylhydrazones and trifluoromethyl 1,3-dicarbonyl arenes...
May 9, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29775157/blood-based-biomarkers-in-breast-cancer-from-proteins-to-circulating-tumor-cells-to-circulating-tumor-dna
#4
Michael J Duffy, Enda W McDermott, John Crown
Biomarkers are the key to personalized treatment in patients with breast cancer. While tissue biomarkers are most useful in determining prognosis and upfront predicting response to therapy, circulating protein biomarkers such as CA 15-3 and carcinoembryonic antigen are mainly used in monitoring response to endocrine or chemotherapy in patients with advanced disease. Although several centers measure biomarkers in asymptomatic patients following curative surgery for primary breast cancer, the clinical utility of this practice is unclear...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29764605/perception-matters-stressful-life-events-increase-breast-cancer-risk
#5
Avital Fischer, Argyrios Ziogas, Hoda Anton-Culver
OBJECTIVE: The relationship between psychological stress and breast cancer risk is unclear. The present study sought to understand how stressfulness appraisal of salient Life Events (LEs) influences breast cancer risk. METHODS: A case-control design was used and included 664 female cases identified through the Cancer Surveillance Program of Orange County, CA and 203 female population-based controls. A LE questionnaire determined if events occurred prior to breast cancer diagnosis and if these events were considered to be stressful or not...
July 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29745746/ca-15-3-predicting-breast-cancer-relapse-beware-of-vitamin-b12-deficiency
#6
Elie El Rassy, Maya Al Ghor, Joseph Kattan
A sustained increase of cancer antigen 15-3 serum levels was found in a 54-year-old woman treated 2 years ago for early stage breast cancer, without any evidence of cancer recurrence. The patient thereafter developed severe megaloblastic anemia secondary to vitamin B12 deficiency. Supplementation with B12 to reverse the anemia led to the normalization of the cancer antigen 15-3 serum levels. As such, with the limited understanding of molecular biology, the integrative approach of clinical history, physical examination, and diagnostic imaging remain pivotal in the management of cancer patients...
May 10, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29737472/snp-rs2071095-in-lincrna-h19-is-associated-with-breast-cancer-risk
#7
Ping Cui, Yanrui Zhao, Xinlei Chu, Na He, Hong Zheng, Jiali Han, Fengju Song, Kexin Chen
PURPOSE: An increasing number of long intergenic non-coding RNAs (lincRNAs) appear to play critical roles in cancer development and progression. To assess the association between SNPs that reside in regions of lincRNAs and breast cancer risk, we performed a large case-control study in China. METHODS: We carried out a two-stage case-control study including 2881 breast cancer cases and 3220 controls. In stage I, we genotyped 17 independent (r2  < 0.5) SNPs located in 6 tumor-related lincRNAs by using the TaqMan platform...
May 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29733543/disparities-in-breast-cancer-a-multi-institutional-comparative-analysis-focusing-on-american-hispanics
#8
Zeina Nahleh, Salman Otoukesh, Hamid Reza Mirshahidi, Anthony Loc Nguyen, Gayathri Nagaraj, Gehan Botrus, Nabeel Badri, Nabih Diab, Andres Alvarado, Luis A Sanchez, Alok K Dwivedi
Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latino women nationwide. Hispanic women are more likely to be presented with advanced disease and adverse prognosis subtypes. The aim of this study is to describe the clinico- pathological characteristics and disparities in breast cancer in this group at two tertiary care University-based medical centers. After IRB approval, Cancer registry was used to analyze the variables of 3441 patients with breast cancer diagnosed and treated consecutively at two large tertiary University based medical and cancer center database centers in El Paso, TX and Loma Linda, CA between 2005 and 2015...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29731666/association-of-two-foxp3-polymorphisms-with-breast-cancer-susceptibility-in-chinese-han-women
#9
Tian Tian, Meng Wang, Yi Zheng, Tielin Yang, Wenge Zhu, Hongtao Li, Shuai Lin, Kang Liu, Peng Xu, Yujiao Deng, Linghui Zhou, Zhijun Dai
Background: Forkhead box P3 ( FOXP3 ) is a key gene in the immune system which also plays a role in tumor development. This study aims to explore the association of two FOXP3 polymorphisms (rs3761548 and rs3761549) with susceptibility to breast cancer (BC). Method: A case-control study was conducted, involving 560 patients and 583 healthy individuals from the Chinese Han population. The genotypes of FOXP3 polymorphisms were detected using the Sequenom MassARRAY method...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29728885/gadopentatic-acid-affects-in-vitro-proliferation-and-doxorubicin-response-in-human-breast-adenocarcinoma-cells
#10
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
Contrasting agents (CAs) that are administered to patients during magnetic resonance imaging to facilitate tumor identification are generally considered harmless. However, gadolinium (Gd) based contrast agents can be retained in the body, inflicting specific cell line cytotoxicity. We investigate the effect of Gadopentatic acid (Gd-DTPA) on human breast adenocarcinoma MCF-7 cells. These cells exhibit a toggle switch response: exposure to 0.1 and 1 mM concentrations of Gd-DTPA enhances proliferation, which is hindered at a higher 10 mM concentration...
May 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29715586/biological-effects-in-photodynamic-treatment-combined-with-electropermeabilization-in-wild-and-drug-resistant-breast-cancer-cells
#11
Joanna Weżgowiec, Julita Kulbacka, Jolanta Saczko, Joanna Rossowska, Grzegorz Chodaczek, Małgorzata Kotulska
Electrochemotherapy became one of the therapeutic protocols successfully used in oncology. However, biological effects occurring in cells, especially those which are drug resistant, have not been studied thoroughly. This study presents response of wild and drug resistant breast cancer cells to classical photodynamic therapy with Photofrin or experimental photodynamic therapy with cyanine IR-775, combined with electroporation. Photodynamic reaction or electroporation alone had no cytotoxic effect, but their combination significantly disturbed cellular functions...
April 19, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29715330/sensing-ca-15-3-in-point-of-care-by-electropolymerizing-o-phenylenediamine-opda-on-au-screen-printed-electrodes
#12
Rui S Gomes, Felismina T C Moreira, Ruben Fernandes, M Goreti F Sales
This work presents an alternative device for cancer screening in liquid biopsies. It combines a biomimetic film (i) with electrochemical detection (ii). The biomimetic film (i) was obtained by electro-polymerizing amine-substituted benzene rings around a CA 15-3 target. This protein target was previously adsorbed on a gold (Au) support and incubated in charged monomers (4-Styrenesulfonate sodium and 3-Hydroxytyraminium chloride). The protein was further eliminated by enzymatic activity, leaving behind vacant sites for subsequent rebinding...
2018: PloS One
https://www.readbyqxmd.com/read/29713287/transcriptional-repression-and-protein-degradation-of-the-ca-2-activated-k-channel-k-ca-1-1-by-androgen-receptor-inhibition-in-human-breast-cancer-cells
#13
Anowara Khatun, Motoki Shimozawa, Hiroaki Kito, Mayu Kawaguchi, Mayu Fujimoto, Moe Ri, Junko Kajikuri, Satomi Niwa, Masanori Fujii, Susumu Ohya
The large-conductance Ca2+ -activated K+ channel KCa 1.1 plays an important role in the promotion of breast cancer cell proliferation and metastasis. The androgen receptor (AR) is proposed as a therapeutic target for AR-positive advanced triple-negative breast cancer. We herein investigated the effects of a treatment with antiandrogens on the functional activity, activation kinetics, transcriptional expression, and protein degradation of KCa 1.1 in human breast cancer MDA-MB-453 cells using real-time PCR, Western blotting, voltage-sensitive dye imaging, and whole-cell patch clamp recording...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29701836/diagnostic-value-of-serum-concentration-and-integrity-of-circulating-cell-free-dna-in-breast-cancer-a-comparative-study-with-cea-and-ca15-3
#14
Zijie Tang, Li Li, Lei Shen, Xianjuan Shen, Shaoqing Ju, Hui Cong
Breast cancer (BC) is one of the most common types of malignant neoplasm in women; the incidence of BC increases yearly. In a previous study, a novel and sensitive method for quantitying cell-free DNA (CFD) in human blood was established and tested for its ability to predict which patients harbored tumors. Our objective in this study was to investigate the clinical value of serum concentration and the integrity of circulating free DNA (CFD) as a biomarker for auxiliary diagnosis of BC. The concentration of CFD was quantitated by branched DNA (bDNA)-based Alu assay...
April 26, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29699375/potential-impact-of-vascular-endothelial-growth-factor-gene-variation-2578c-a-on-breast-cancer-susceptibility-in-saudi-arabia-a-case-control-study
#15
Ibrahim Abdullah Al Balawi, Rashid Mir, F M Abu-Duhier
Aim: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with altered promoter activity. The VEGF rs699947 SNP is located in the promoter region and is associated with susceptibility to breast carcinoma development. Here, we investigated the association of the -2578C>A polymorphism in the VEGF gene with breast cancer risk in Saudi women. Methodology: Genotyping of the VEGF-gene variation (-2578A>C) was performed using the amplification refractory mutation system PCR. We investigated the association of VEGF gene variants with different clinicopathological features of breast cancer patients...
April 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29676660/new-tailored-substituted%C3%A2-benzothiazole-schiff-base-cu-ii-zn-ii-antitumor-drug-entities-effect-of-substituents-on-dna-binding-profile-antimicrobial-and-cytotoxic-activity
#16
Siffeen Zehra, Mohammad Shavez Khan, Iqbal Ahmad, Farukh Arjmand
New tailored Cu(II) & Zn(II) metal-based antitumor drug entities were synthesized from substituted benzothiazole o‒vanillin Schiff base ligands. The complexes were thoroughly characterized by elemental analysis, spectroscopic studies {IR, 1 H & 13 C NMR, ESI-MS, EPR} and magnetic susceptibility measurements. The structure activity relationship (SAR) studies of benzothiazole Cu(II) & Zn(II) complexes having molecular formulas [C30 H22 CuN5 O7 S2 ], [C30 H20 Cl2 CuN5 O7 S2 ], [C30 H20 CuF2 N5 O7 S2 ], [C30 H22 N4 O4 S2 Zn], [C30 H20 Cl2 N4 O4 S2 Zn] and [C30 H20 F2 N5 O7 S2 Zn], with CT‒DNA were performed by employing absorption, emission titrations and hydrodynamic measurements...
April 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29656388/preliminary-results-of-acoustic-radiation-force-impulse-imaging-by-combined-qualitative-and-quantitative-analyses-for-evaluation-of-breast-lesions
#17
Lin Wang, Cai-Feng Wan, Jing Du, Feng-Hua Li
OBJECTIVES: The purpose of this study was to evaluate the application of a new elastographic technique, acoustic radiation force impulse (ARFI) imaging, and its diagnostic performance for characterizing breast lesions. METHODS: One hundred consecutive female patients with 126 breast lesions were enrolled in our study. After routine breast ultrasound examinations, the patients underwent ARFI elasticity imaging. Virtual Touch tissue imaging (VTI) and Virtual Touch tissue quantification (Siemens Medical Solutions, Mountain View, CA) were used to qualitatively and quantitatively analyze the elasticity and hardness of tumors...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29621501/an-innovative-immunoassay-for-ultrasensitive-detection-of-breast-cancer-specific-carbohydrate-ca-15-3-in-unprocessed-human-plasma-and-mcf-7-breast-cancer-cell-lysates-using-gold-nanospear-electrochemically-assembled-onto-thiolated-graphene-quantum-dots
#18
Mohammad Hasanzadeh, Solmaz Tagi, Elham Solhi, Ahad Mokhtarzadeh, Nasrin Shadjou, Aziz Eftekhari, Soltanali Mahboob
The accurate quantification of the level of breast cancer specific protein CA 15-3 in serum is crucial for cancer prognosis. This work, a novel and sensitive label-free immunoassay based on gold nanospear (Au NSs) electrochemically assembled onto thiolated graphene quantum dots (CysA/GQDs) for the detection of CA 15-3 antibodies. The CysA/Au NSs/GQDs hybrid interface provides a large surface area for the effective immobilization of CA 15-3 antigens, as well as it ascertains the bioactivity and stability of immobilized CA 15-3 antigens...
April 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29611386/comparison-of-four-automated-carcinoembryonic-antigen-immunoassays-advia-centaur-xp-architect-i2000sr-elecsys-e170-and-unicel-dxi800
#19
Joonhong Park, Seungok Lee, Yeongsic Kim, Aeran Choi, Hyeyoung Lee, Jihyang Lim, Yonggoo Kim, Kyungja Han, Eun Jee Oh
BACKGROUND: Carcinoembryonic antigen (CEA) is one of the tumor markers available for evaluating disease progression status after initial therapy and monitoring subsequent treatment modalities in colorectal, gastrointestinal, lung, and breast carcinoma. We evaluated the correlations and differences between widely used, automated CEA immunoassays at four different medical laboratories. METHODS: In total, 393 serum samples with CEA ranging from 3.0 to 1,000 ng/mL were analyzed on ADVIA Centaur XP (Siemens Diagnostics, Tarrytown, NY, USA), ARCHITECT i2000sr (Abbott Diagnostics, Abbott Park, IL, USA), Elecsys E170 (Roche Diagnostics, Indianapolis, IN, USA), and Unicel DxI800 (Beckman Coulter, Fullerton, CA, USA), and the results were compared...
July 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29609845/evolution-of-brachytherapy-treatment-planning-to-deterministic-radiation-transport-for-calculation-of-cardiac-dose
#20
REVIEW
Peter A Sandwall, Yuntao Feng, Michael Platt, Michael Lamba, Sudha Mahalingam
Brachytherapy was among the first methods of radiotherapy and has steadily continued to evolve. Here we present a brief review of the progression of dose calculation methods in brachytherapy to the current state-of-the art computerized methods for heterogeneity correction. We further review the origin and development of the BrachyVision (Varian Medical Systems, Inc., Palo Alto, CA) treatment planning system and evaluate dosimetric results from 12 patients implanted with the strut-assisted volumetric implant (SAVI) applicator (Cianna Medical, Aliso Viejo, CA) for accelerated partial breast irradiation (APBI)...
March 30, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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