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Thyroid Neoplasm

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https://www.readbyqxmd.com/read/28338500/differential-diagnosis-in-neuroendocrine-neoplasms-of-the-larynx
#1
Jennifer L Hunt, Alfio Ferlito, Henrik Hellquist, Alessandra Rinaldo, Alena Skálová, Pieter J Slootweg, Stefan M Willems, Antonio Cardesa
The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis and treatment are also different among these tumor types, which necessitates making these distinctions clinically. The current literature was reviewed to provide updated information regarding the epithelial-derived tumors, including carcinoid, atypical carcinoid, small cell neuroendocrine carcinomas, large cell neuroendocrine carcinoma, and squamous cell carcinoma with neuroendocrine component...
March 23, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28338469/the-utility-of-thyroid-ultrasonography-in-the-management-of-thyroid-nodules
#2
Gary Gamme, Tyler Parrington, Edward Wiebe, Sunita Ghosh, Brendan Litt, David C Williams, Todd P W McMullen
BACKGROUND: Ultrasonography for thyroid nodules is one of the most common imaging tests performed in the general population. Details from ultrasound reports guide biopsies and surgery. This study quantifies the completeness of these reports based on Thyroid Imaging and Reporting System (TI-RADS) criteria and considers their utility in predicting malignant disease. METHODS: We retrospectively reviewed ultrasound reports for 329 thyroidectomy patients and extracted data elements using the TI-RADS criteria: nodule size, echogenicity, margins, vascularity, solid/cystic composition and the presence or absence of microcalcifications and the halo sign...
April 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28332339/sonographic-and-cytologic-differences-of-niftp-from-infiltrative-or-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-a-review-of-179-cases
#3
REVIEW
Grace C H Yang, Karen O Fried, Theresa Scognamiglio
We reclassified 179 cases of the follicular variant (FV) of papillary thyroid carcinoma (PTC) into 72 (40.2%) noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 37 (20.7%) encapsulated FVPTC with invasion (EFVPTC), and 70 (39.1%) infiltrative FVPTC (IFVPTC) without a capsule. In the NIFTP group, 5.6% cytology were hypercellular and the remainder low to moderate cellularity. PTC nuclei were absent in 18%, focally present in 37.5%, and diffusely present in 44.4%. In the EFVPTC group, 8...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28314541/risk-of-subsequent-primary-kidney-cancer-after-another-malignancy-a-population-based-study
#4
Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of kidney cancer as a second malignant neoplasm following the diagnosis of other common malignancies are rare. This clinical scenario has been evaluated within the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: The SEER-9 database (1973-2013) was queried using the SEER*Stat program to determine the standardized incidence ratios (SIRs) of kidney cancer development following each one of 10 common invasive malignancies (colorectal, breast, prostate, lung, thyroid, corpus uteri, urinary bladder, kidney/renal pelvis, cutaneous melanoma, and non-Hodgkin lymphoma)...
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28297767/-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#5
Z Y Liu
No abstract text is available yet for this article.
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28296267/can-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-be-distinguished-from-classic-papillary-thyroid-carcinoma-and-follicular-adenomas-by-fine-needle-aspiration
#6
Tamar C Brandler, Fang Zhou, Cheng Z Liu, Margaret Cho, Ryan P Lau, Aylin Simsir, Kepal N Patel, Wei Sun
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma, a diagnosis implying malignancy as a variant of papillary thyroid carcinoma (PTC), has recently been reclassified to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on surgical pathology. Due to the effects of such a recategorization on rate of malignancy and clinical management algorithms, it is imperative that we explore whether presurgical fine-needle aspiration can differentiate NIFTP from PTC and follicular adenoma (FA)...
March 10, 2017: Cancer
https://www.readbyqxmd.com/read/28295000/current-status-of-radiopharmaceuticals-for-the-theranostics-of-neuroendocrine-neoplasms
#7
REVIEW
Melpomeni Fani, Petra Kolenc Peitl, Irina Velikyan
Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them...
March 15, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28293988/molecular-profiling-of-papillary-thyroid-carcinoma-in-korea-with-high-prevalence-of-braf-v600e-mutation
#8
Seung Eun Lee, Tae Sook Hwang, Yoon-La Choi, Wook Youn Kim, So Duk Lim, Young Bum Yoo, Suk Kyeong Kim
BACKGROUND: BRAF V600E mutation in PTC is particularly prevalent in Korea and a considerable number of BRAF-wild PTCs harbor RAS mutations. In addition, subsets of other genetic alterations clearly exist, but their prevalence in the Korean population has not been well studied. Recent increased insight into noninvasive encapsulated follicular variant PTC (NIE-FVPTC) has prompted endocrine pathologists to reclassify this entity as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features...
March 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28288025/coffee-and-cancer-risk-a-summary-overview
#9
Gianfranco Alicandro, Alessandra Tavani, Carlo La Vecchia
We reviewed available evidence on coffee drinking and the risk of all cancers and selected cancers updated to May 2016. Coffee consumption is not associated with overall cancer risk. A meta-analysis reported a pooled relative risk (RR) for an increment of 1 cup of coffee/day of 1.00 [95% confidence interval (CI): 0.99-1.01] for all cancers. Coffee drinking is associated with a reduced risk of liver cancer. A meta-analysis of cohort studies found an RR for an increment of consumption of 1 cup/day of 0.85 (95% CI: 0...
March 10, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28286028/spindle-cell-oncocytoma-report-of-two-cases-with-massive-bleeding-and-review-of-the-literature
#10
REVIEW
Domenico Billeci, Elisabetta Marton, Enrico Giordan, Valentina Carraro, Monica Ronzon, Sabrina Rossi
Spindle cell oncocytoma (SCO) is a rare pituitary tumor, classified as a WHO grade I neoplasm. Due to its rarity, SCO is often preoperatively misdiagnosed as a pituitary macroadenoma. In the present study we report two recent cases of SCO, a 61-year-old male and a 65-year-old female presenting at Treviso General Hospital between March 2014 and April 2015. Tumor resection was achieved by endoscopic transsphenoidal approach but massive hemorrhagic events hampered surgery, endangering the patient's life in both cases...
March 9, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28281551/molecular-correlates-and-rate-of-lymph-node-metastasis-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-invasive-follicular-variant-papillary-thyroid-carcinoma-the-impact-of-rigid-criteria-to-distinguish-non-invasive-follicular
#11
Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
Thyroid tumors formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma were recently renamed 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features'. The current study investigated the frequency of lymph node metastasis and mutational profile of encapsulated follicular variant in the setting of a clinical practice where central neck dissection was the standard of practice. We defined the impact of rigid diagnostic criteria by regrouping such tumors based on the complete absence of papillae or presence of ≤1% papillae...
March 10, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28280647/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-an-evidence-based-nomenclature-change
#12
REVIEW
Rachel Jug, Xiaoyin Jiang
A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including papillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. From a molecular standpoint, NIFTP is often characterized by RAS-type mutations, similar to other follicular-patterned lesions...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28280507/fine-needle-aspiration-of-thyroid-nodules-using-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience-in-a-rural-setting
#13
Aili Guo, Yuuki Kaminoh, Terra Forward, Frank L Schwartz, Scott Jenkinson
Background. Fine needle aspiration (FNA) remains the first-line diagnostic in management of thyroid nodules and reduces unnecessary surgeries. However, it is still challenging since cytological results are not always straightforward. This study aimed to examine the results of thyroid FNA using the Bethesda system for reporting thyroid cytopathology (TBSRTC) to establish the level of accuracy of FNA procedures in a rural practice setting. Method. A retrospective chart review was conducted on existing thyroid FNA performed in a referral endocrine center between December 2011 and November 2015...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28271380/the-flip-side-of-niftp-an-increase-in-rates-of-unfavorable-histologic-parameters-in-the-remainder-of-papillary-thyroid-carcinomas
#14
Kristine S Wong, Kyle C Strickland, Trevor E Angell, Matthew A Nehs, Erik K Alexander, Edmund S Cibas, Jeffrey F Krane, Brooke E Howitt, Justine A Barletta
The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) both to promote more conservative management of these tumors and spare patients the psychological burden of a cancer diagnosis. This reclassification will lower the incidence of papillary thyroid carcinoma (PTC). In addition, it could result in an increase in the rates of unfavorable histologic prognosticators for PTC overall because NIFTPs had previously accounted for many of the PTCs without these features...
March 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28271050/incidental-finding-of-adrenal-oncocytoma-after-right-robotic-adrenalectomy-case-report-and-literature-review
#15
Othman Alamoudi, Wael Alsulaiman, Naif Aldhaam, Maher Moazin
Oncocytic neoplasms occur in several organs and are most commonly found in the thyroid, kidneys and salivary glands. Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually non-functioning, benign and incidentally detected. However, histologically, they are characterized by cells with eosinophilic granular cytoplasm and numerous packed mitochondria. We report a case of 33 year old lady medically free complain of right flank pain radiated to the lower abdomen, not associated with any aggravating or relieving factor or any other symptom there was no evidence of hypertension symptom, by the Magnetic resonance imaging (MRI) showed that she has large heterogeneous mass seen at the right adrenal gland, and it was managed successfully by Robot-Assisted Right Adrenalectomy...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28264709/a-rare-presentation-of-myxofibrosarcoma-as-a-pancoast-tumor-a-case-report
#16
Vasa Jevremovic, Adnan Yousuf, Zulfiqar Hussain, Amer Abboud, Edgar G Chedrawy
BACKGROUND: Myxofibrosarcoma is an aggressive soft tissue neoplasm, classified as a variant of malignant fibrous histiocytoma. Most often, it occurs in middle to late adult life peaking in the seventh decade and involving the lower extremities (77%), trunk (12%), and retroperitoneum or mediastinum (8%). We report the first case of thoracic myxofibrosarcoma presenting as a Pancoast tumor. CASE PRESENTATION: A 48-year-old non-tobacco smoking African-American man presented with a slow-growing mass in his neck along with 11 kg weight loss over 9 months...
March 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28262004/update-on-the-cytologic-features-of-papillary-thyroid-carcinoma-variants
#17
REVIEW
Marc Pusztaszeri, Manon Auger
Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP)...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28261999/cytological-evaluation-by-fine-needle-aspiration-biopsy-of-incidental-focal-increased-fluorodeoxyglucose-uptake-in-thyroid-on-positron-emission-tomography-scan
#18
Yanchun Li, Min Cui, Nami Azar, Dean Nakamoto, Claire W Michael
BACKGROUND: With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis of neoplasia, thyroid incidentalomas have become more common. The limited reports of PET-positive thyroid incidentalomas showed incidence of malignancy ranging from 14 to 66%, and there is discrepancy in terms of the diagnostic significance of the standard uptake value (SUV) value. METHODS: This is a retrospective study of 20 PET incidentalomas which had cytological evaluation from October 2009 to February 2015 at a tertiary care university medical center, M:F = 8:12...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28259878/diagnostic-accuracy-of-fine-needle-aspiration-in-thyroid-nodules-arising-in-patients-with-graves-disease
#19
Jen-Fan Hang, Mohammed T Lilo, Justin A Bishop, Syed Z Ali
OBJECTIVE: Cytopathologic interpretation in Graves disease (GD) is considered challenging due to significant cellular atypia. STUDY DESIGN: We retrospectively identified 55 fine needle aspirations (FNAs) from 43 patients with GD that subsequently underwent thyroidectomy from 1995 to 2016. RESULTS: There were 5 patients with papillary thyroid carcinoma (PTC) and 4 with follicular adenoma (FA). Of the 5 patients with PTC, FNA was interpreted as PTC in 3, atypia of undetermined significance (AUS) in 1, and adenomatoid nodule (AN) in 1 (with a 0...
March 4, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28256078/ultrasonography-and-cytology-as-predictors-of-noninvasive-follicular-thyroid-niftp-neoplasm-with-papillary-like-nuclear-features-importance-of-the-differential-diagnosis-with-the-invasive-encapsulated-follicular-variant-of-papillary-thyroid-cancer
#20
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