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https://www.readbyqxmd.com/read/28820080/diet-quality-and-its-implications-on-the-cardio-metabolic-physical-and-general-health-of-older-men-the-concord-health-and-ageing-in-men-project-champ
#1
Rosilene V Ribeiro, Vasant Hirani, Alistair M Senior, Alison K Gosby, Robert G Cumming, Fiona M Blyth, Vasi Naganathan, Louise M Waite, David J Handelsman, Hal Kendig, Markus J Seibel, Stephen J Simpson, Fiona Stanaway, Margaret Allman-Farinelli, David G Le Couteur
The revised Dietary Guideline Index (DGI-2013) scores individuals' diets according to their compliance with the Australian Dietary Guideline (ADG). This cross-sectional study assesses the diet quality of 794 community-dwelling men aged 74 years and older, living in Sydney, Australia participating in the Concord Health and Ageing in Men Project; it also examines sociodemographic and lifestyle factors associated with DGI-2013 scores; it studies associations between DGI-2103 scores and the following measures: homoeostasis model assessment - insulin resistance, LDL-cholesterol, HDL-cholesterol, TAG, blood pressure, waist:hip ratio, BMI, number of co-morbidities and medications and frailty status while also accounting for the effect of ethnicity in these relationships...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28818421/erbb-signaling-antagonist-ameliorates-behavioral-deficit-induced-by-phencyclidine-pcp-in-mice-without-affecting-metabolic-syndrome-markers
#2
Hagar Tadmor, Idit Golani, Ravid Doron, Ilana Kremer, Alon Shamir
Schizophrenia is a severe syndrome that affects about 1% of the world population. Since the mid-1950s, antipsychotics have been used to treat schizophrenia with preference for treating positive symptoms; however, their tolerance level is low, there are numerous side effects, and only some patients respond to the treatment. Antipsychotic medications that are more effective, better tolerated, and with fewer adverse effects are urgently needed. Given the accumulating evidence of the role filled by the ErbB signaling network in the biology of the dopamine, GABA, and glutamate systems, and in the etiology of schizophrenia, we hypothesized that the ErbB network is a candidate for development of a novel agent through which various symptoms of schizophrenia and other psychiatric disorders might be treated...
August 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28814963/effects-of-a-liquid-high-fat-meal-on-postprandial-lipid-metabolism-in-type-2-diabetic-patients-with-abdominal-obesity
#3
Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu, Guiju Sun
BACKGROUND: Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingestion of a liquid high-fat meal in type 2 diabetic patients with abdominal obesity, and determine if the PvuII polymorphisms of LPL influence their postprandial lipid responses. METHODS: Serum glucose, insulin, triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured in fasting and postprandial state at 0...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28814962/circulating-zinc-%C3%AE-2-glycoprotein-levels-are-low-in-newly-diagnosed-patients-with-metabolic-syndrome-and-correlate-with-adiponectin
#4
Lu Lei, Kejia Li, Ling Li, Xia Fang, Tingting Zhou, Cheng Zhang, Yong Luo, Hua Liu, Xiaoqiang Li, Hongting Zheng, Lin Zhang, Gangyi Yang, Lin Gao
BACKGROUND: Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigate the association of circulating ZAG with metabolic syndrome (MetS) in middle-aged and older Chinese adults. METHODS: Four hundred eighty nine individuals (234 healthy controls and 255 MetS patients) were examined. All individuals were screened for MetS according to the diagnostic guidelines of the United States National Cholesterol Education Program (NCEP) Expert Panel Adult Treatment Panel (ATP) III criteria...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28812403/text-messaging-sms-as-a-tool-to-facilitate-weight-loss-and-prevent-metabolic-deterioration-in-clinically-healthy-overweight-and-obese-subjects-a-randomised-controlled-trial
#5
Vija Silina, Mesfin K Tessma, Silva Senkane, Gita Krievina, Guntis Bahs
OBJECTIVE: To examine whether SMS text messaging facilitates a reduction of weight and waist circumference (WC) and favourable changes in lipid profile and insulin levels in clinically healthy overweight and obese subjects. DESIGN: A randomised controlled trial. SETTING AND INTERVENTION: Primary care health centre in Riga, Latvia. Text messaging once in two weeks. SUBJECTS: A total of 123 overweight and obese men and women aged 30-45 years with no cardiovascular diseases (CVDs) or diabetes...
August 16, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28811852/the-cluster-of-abnormalities-related-to-metabolic-syndrome-is-associated-with-reduced-glomerular-filtration-rate-and-raised-albuminuria-in-patients-with-type-2-diabetes-mellitus
#6
Miki Kurata, Akiko Takenouchi, Ayaka Tsuboi, Satomi Minato, Mika Takeuchi, Kaori Kitaoka, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: As association of metabolic syndrome (MS) with chronic kidney disease (CKD) has not been extensively studied in patients with type 2 diabetes, we addressed these issues. METHODS: Intrapersonal means of 12 measurements of waist circumference, blood pressure and high-density lipoprotein (HDL) cholesterol and those of six measurements of fasting triglycerides during 12 months were calculated in a cohort of 168 previously reported Japanese patients with type 2 diabetes...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811795/comparison-of-adjunctive-therapy-with-metformin-and-acarbose-in-patients-with-type-1-diabetes-mellitus
#7
Amir Ziaee, Neda Esmailzadehha, Maryam Honardoost
OBJECTIVE: All the aforementioned data have stimulated interest in studying other potential therapies for T1DM including noninsulin pharmacological therapies. The present study attempts to investigate the effect of adjunctive therapy with metformin and acarbose in patients with Type-1 diabetes mellitus. METHOD: In a single-center, placebo-controlled study (IRCT201102165844N1) we compared the results of two clinical trials conducted in two different time periods on 40 patients with Type-1 diabetes mellitus...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811698/effect-of-tulsi-ocimum-sanctum-linn-supplementation-on-metabolic-parameters-and-liver-enzymes-in-young-overweight-and-obese-subjects
#8
Swayamjeet Satapathy, Namrata Das, Debapriya Bandyopadhyay, Sushil Chandra Mahapatra, Dip Sundar Sahu, Mruthyumjayarao Meda
Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28811382/an-engineered-s1p-chaperone-attenuates-hypertension-and-ischemic-injury
#9
Steven L Swendeman, Yuquan Xiong, Anna Cantalupo, Hui Yuan, Nathalie Burg, Yu Hisano, Andreane Cartier, Catherine H Liu, Eric Engelbrecht, Victoria Blaho, Yi Zhang, Keisuke Yanagida, Sylvain Galvani, Hideru Obinata, Jane E Salmon, Teresa Sanchez, Annarita Di Lorenzo, Timothy Hla
Endothelial dysfunction, a hallmark of vascular disease, is restored by plasma high-density lipoprotein (HDL). However, a generalized increase in HDL abundance is not beneficial, suggesting that specific HDL species mediate protective effects. Apolipoprotein M-containing HDL (ApoM(+)HDL), which carries the bioactive lipid sphingosine 1-phosphate (S1P), promotes endothelial function by activating G protein-coupled S1P receptors. Moreover, HDL-bound S1P is limiting in several inflammatory, metabolic, and vascular diseases...
August 15, 2017: Science Signaling
https://www.readbyqxmd.com/read/28810876/prenatal-caloric-restriction-alters-lipid-metabolism-but-not-hepatic-fasn-gene-expression-and-methylation-profiles-in-rats
#10
Joanna Nowacka-Woszuk, Zofia E Madeja, Agata Chmurzynska
BACKGROUND: Undernutrition is an increasingly common problem. Insufficient calorie intake and nutrient deficiencies during pregnancy may have an impact not only on the mother, but may also alter metabolism in the infant. In this study, we have applied a calorie-restricted diet during gestation and examined its effect on hepatic Fasn mRNA and DNA methylation profiles in rats and their female progeny. The body composition and blood lipid profiles were also evaluated in both generations...
August 15, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28810840/the-association-between-tuberculosis-and-the-development-of-insulin-resistance-in-adults-with-pulmonary-tuberculosis-in-the-western-sub-district-of-the-cape-metropole-region-south-africa-a-combined-cross-sectional-cohort-study
#11
Lauren Philips, Janicke Visser, Daan Nel, Renée Blaauw
BACKGROUND: The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk, the relationship between tuberculosis as a causative factor for IR remains unclear. The study aimed to determine if an association existed between tuberculosis and IR development in adults with newly diagnosed pulmonary tuberculosis at baseline. It was additionally aimed to document changes in IR status during TB follow-up periods...
August 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28808791/consumption-of-extra-virgin-olive-oil-improves-body-composition-and-blood-pressure-in-women-with-excess-body-fat-a-randomized-double-blinded-placebo-controlled-clinical-trial
#12
Flávia Galvão Cândido, Flávia Xavier Valente, Laís Emilia da Silva, Olívia Gonçalves Leão Coelho, Maria do Carmo Gouveia Peluzio, Rita de Cássia Gonçalves Alfenas
PURPOSE: Despite the fact that extra virgin olive oil (EVOO) is widely used in obese individuals to treat cardiovascular diseases, the role of EVOO on weight/fat reduction remains unclear. We investigated the effects of energy-restricted diet containing EVOO on body composition and metabolic disruptions related to obesity. METHODS: This is a randomized, double-blinded, placebo-controlled clinical trial in which 41 adult women with excess body fat (mean ± SD 27...
August 14, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28808191/shunts-channels-and-lipoprotein-endosomal-traffic-a-new-model-of-cholesterol-homeostasis-in-the-hepatocyte
#13
Robert Scott Kiss, Allan Sniderman
The liver directs cholesterol metabolism in the organism. All the major fluxes of cholesterol within the body involve the liver: dietary cholesterol is directed to the liver; cholesterol from peripheral cells goes to the liver; the liver is a major site of cholesterol synthesis for the organism; cholesterol is secreted from the liver within the bile, within apoB lipoproteins and translocated to nascent HDL. The conventional model of cholesterol homeostasis posits that cholesterol from any source enters a common, rapidly exchangeable pool within the cell, which is in equilibrium with a regulatory pool...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807460/metabolic-syndrome-cluster-does-not-provide-incremental-prognostic-information-in-patients-with-stable-cardiovascular-disease-a-post-hoc-analysis-of-the-aim-high-trial
#14
Radmila Lyubarova, Jennifer G Robinson, Michael Miller, Debra L Simmons, Ping Xu, Beth L Abramson, Marshall B Elam, Todd M Brown, Ruth McBride, Jerome L Fleg, Patrice Desvigne-Nickens, Woubeshet Ayenew, William E Boden
BACKGROUND: Metabolic syndrome (MS) is a well-known risk factor for the development of cardiovascular (CV) disease; yet, controversy persists whether it adds incremental prognostic value in patients with established CV disease. OBJECTIVES: This study was performed to determine if MS is associated with worse CV outcomes in patients with established CV disease treated intensively with statins. METHODS: We performed a post hoc analysis of the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes trial, in which patients with established CV disease and atherogenic dyslipidemia (n = 3414) were randomly assigned to receive extended release niacin or placebo during a mean 36-month follow-up, to assess whether the presence of MS or the number of MS components contributed to CV outcomes...
July 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28806974/association-of-plasma-fatty-acid-alteration-with-the-severity-of-coronary-artery-disease-lesions-in-tunisian-patients
#15
Samia Hadj Ahmed, Nadia Kaoubaa, Wafa Kharroubi, Amira Zarrouk, Mohamed Fadhel Najjar, Fathi Batbout, Habib Gamra, Gerard Lizard, Mohamed Hammami
BACKGROUND: Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. METHODS: The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls. RESULTS: CAD patients showed an alteration of conventional lipid parameters...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28804718/cd36-gene-polymorphisms-are-associated-with-intracerebral-hemorrhage-susceptibility-in-a-han-chinese-population
#16
Qiu-Wen Gong, Mao-Fan Liao, Liang Liu, Xiao-Yi Xiong, Qin Zhang, Qi Zhong, Kai Zhou, Yuan-Rui Yang, Zhao-You Meng, Chang-Xiong Gong, Rui Xu, Qing-Wu Yang
The CD36 gene encodes a membrane glycoprotein (type B scavenger receptor, SR-B2) that plays a crucial role in lipid sensing, innate immunity, atherogenesis, and glycolipid metabolism. In this study, we aimed to investigate the association between CD36 gene polymorphisms and intracerebral hemorrhage (ICH) in a Han Chinese population. We performed genotype and allele analyses for eleven single nucleotide polymorphisms (SNPs) of CD36 in a case-controlled study involving 292 ICH patients and 298 control participants...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28804682/effects-of-intensive-pitavastatin-therapy-on-glucose-control-in-patients-with-non-st-elevation-acute-coronary-syndrome
#17
Yan-Bo Wang, Xiang-Hua Fu, Xin-Shun Gu, Wei-Ze Fan, Yun-Fa Jiang, Guo-Zhen Hao, Qing Miao, Jie Cao, Bing Fu, Yi Li
Objective: This study aimed to investigate the effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome (ACS). Methods: Patients who had ACS with significant stenosis on initial coronary angiography and received successful percutaneous coronary intervention (PCI) in the Second Hospital of Hebei Medical University, Shijiazhuang, China from August 2015 to January 2016 were enrolled in this study. The patients were randomized to receive pitavastatin (4 mg daily) or atorvastatin (20 mg daily)...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28802821/association-of-sex-hormones-with-metabolic-syndrome-among-egyptian-males
#18
Iman Z Ahmed, Maram M Mahdy, Hussein El Oraby
BACKGROUND: Studies have shown that testosterone and estradiol (E2) are associated with metabolic syndrome (MetS). To our knowledge, few studies, if any about the association of endogenous sex hormones with MetS have been done in Egypt. AIM: To study the relation between endogenous sex hormones and MetS among Egyptian males. SUBJECTS AND METHOD: For the study, 80 Egyptian males were enrolled: 40 males with MetS and 40 healthy age-matched males...
August 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28800398/a-13-week-randomized-pilot-trial-of-a-low-glycemic-load-diet-and-lifestyle-modification-program-combining-low-glycemic-load-protein-shakes-and-targeted-nutraceuticals-improved-weight-loss-and-cardio-metabolic-risk-factors-over-a-low-glycemic-load-diet-alone
#19
Clinton J Dahlberg, Joseph J Ou, John G Babish, Joseph J Lamb, Sarah Eliason, Holly Brabazon, Wei Gao, Mohan R Kaadige, Matthew L Tripp
An open label, randomized, exploratory study comprising 44 healthy, overweight subjects with cardio-metabolic syndrome (CMS) risk factors was conducted to assess the safety, tolerability and efficacy of a proprietary lifestyle modification program without (DIET) and with (PROG) targeted nutraceutical supplementation including soy, pea and whey proteins, phytosterols, antioxidants, probiotics, fish oil and berberine over 13-weeks. Key metrics were recorded at baseline, weeks 9 and 13. For DIET and PROG compliance was 85% and 86%, respectively, with no adverse events related to the diet or supplements...
August 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28797575/cardiovascular-risk-profile-in-burn-survivors
#20
Becky Leung, John F Younger, Kellie Stockton, Michael Muller, Jennifer Paratz
OBJECTIVE: Burn patients have prolonged derangements in metabolic, endocrine, cardiac and psychosocial systems, potentially impacting on their cardiovascular health. There are no studies on the risk of cardiovascular disease (CVD) after-burn. The aim of our study was to record lipid values and evaluate CVD risk in adult burn survivors. METHODS: In a cross-sectional study patients ≥18 years with burn injury between 18-80% total burn surface area (TBSA) from 1998 to 2012 had total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides measured via finger prick...
August 7, 2017: Burns: Journal of the International Society for Burn Injuries
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