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https://www.readbyqxmd.com/read/29665358/hyperinsulinemic-euglycemic-clamp-over-the-first-year-of-use-of-depot-medroxyprogesterone-acetate-as-a-contraceptive
#1
Vaneska Melhado-Kimura, Gisele Almeida Batista, Aglécio Luiz de Souza, Priscilla de Nazaré Silva Dos Santos, Sarah Monte Alegre, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
OBJECTIVE: The literature lacks data on the use of the gold-standard hyperinsulinemic-euglycemic clamp (HEC) technique for the evaluation of insulin resistance (IR) in depot-medroxyprogesterone acetate (DMPA) users. This study assessed carbohydrate metabolism in non-obese users of DMPA using the HEC technique. STUDY DESIGN: A prospective, non-randomized, comparative study conducted at the Family Planning Clinic/Metabolic Unit, University of Campinas, Brazil. Forty-eight women aged 18-39 years underwent HEC: 30 initiating use of DMPA and 18 initiating use of a copper intrauterine device (IUD)...
April 14, 2018: Contraception
https://www.readbyqxmd.com/read/29662003/ppar-agonists-and-metabolic-syndrome-an-established-role
#2
REVIEW
Margherita Botta, Matteo Audano, Amirhossein Sahebkar, Cesare R Sirtori, Nico Mitro, Massimiliano Ruscica
Therapeutic approaches to metabolic syndrome (MetS) are numerous and may target lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated receptors (PPARs) are involved in the metabolic regulation of lipid and lipoprotein levels, i.e., triglycerides (TGs), blood glucose, and abdominal adiposity. PPARs may be classified into the α, β/δ and γ subtypes. The PPAR-α agonists, mainly fibrates (including newer molecules such as pemafibrate) and omega-3 fatty acids, are powerful TG-lowering agents...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29661785/the-prevalence-of-the-metabolic-syndrome-and-associated-cardiovascular-complications-in-adult-onset-ghd-during-gh-replacement-a-kims-analysis
#3
Johan Verhelst, Anders Mattsson, Cecilia Camacho-Hubner, Anton Luger, Roger Abs
BACKGROUND: Adult-onset GH deficiency (AO-GHD) is associated with a increased prevalence of the metabolic syndrome (MetS). AIM: To determine the effect of GH replacement on the prevalence of MetS in AO-GHD and to study the impact of MetS on the incidence of cardiovascular events during GH replacement. PATIENTS AND METHODS: 1449 AO-GHD patients (males 48.9%; mean age 48.9 ± 12.8 yr) were retrieved from KIMS (Pfizer International Metabolic Database)...
April 16, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29661175/adherence-to-the-qatar-dietary-guidelines-a-cross-sectional-study-of-the-gaps-determinants-and-association-with-cardiometabolic-risk-amongst-adults
#4
Mohammed Al Thani, Al Anoud Al Thani, Walaa Al-Chetachi, Badria Al Malki, Shamseldin A H Khalifa, Ahmad Haj Bakri, Nahla Hwalla, Farah Naja, Lara Nasreddine
BACKGROUND: The Qatar Dietary Guidelines (QDGs) were developed as part of the national strategy to prevent chronic diseases. This study aims at characterizing gaps between the QDGs and usual dietary and lifestyle patterns in Qatar, identifying demographic and socioeconomic determinants of adherence to the QDGs and investigating the association between adherence and cardiometabolic risk. METHODS: This study is based on the Qatar National STEPwise cross-sectional survey which was conducted on a nationally representative sample of Qatari adults, aged 18 to 64 years (n = 1109)...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29659954/the-ossabaw-pig-is-a-suitable-translational-model-to-evaluate-dietary-patterns-and-coronary-artery-disease-risk
#5
Nirupa R Matthan, Gloria Solano-Aguilar, Huicui Meng, Stefania Lamon-Fava, Audrey Goldbaum, Maura E Walker, Saebyeol Jang, Sukla Lakshman, Aleksey Molokin, Yue Xie, Ethiopia Beshah, James Stanley, Joseph F Urban, Alice H Lichtenstein
Background: Animal models that mimic diet-induced human pathogenesis of chronic diseases are of increasing importance in preclinical studies. The Ossabaw pig is an established model for obesity-related metabolic disorders when fed extreme diets in caloric excess. Objective: To increase the translational nature of this model, we evaluated the effect of diets resembling 2 human dietary patterns, the Western diet (WD) and the Heart Healthy Diet (HHD), without or with atorvastatin (-S or +S) therapy, on cardiometabolic risk factors and atherosclerosis development...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659898/cholesterol-metabolism-is-enhanced-in-the-liver-and-brain-of-children-with-citrin-deficiency
#6
Satoshi Hirayama, Hironori Nagasaka, Akira Honda, Haruki Komatsu, Takahiro Kodama, Ayano Inui, Ichiro Morioka, Shunsaku Kaji, Tsuyoshi Ueno, Kenji Ihara, Mariko Yagi, Zenro Kizaki, Kazuhiko Bessho, Hiroki Kondou, Tohru Yorifuji, Hirokazu Tsukahara, Kazumoto Iijima, Takashi Miida
Context: Citrin-deficient infants present neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), which resolves at 12 months. Thereafter, they have normal liver function associated with hypercholesterolemia, and a preference for lipid-rich carbohydrate-restricted diets. However, some develop adult-onset type II citrullinemia (CTLN2), which is associated with metabolic abnormalities. Objectives: To identify the causes of hypercholesterolemia in citrin-deficient children post-NICCD...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659888/randomized-placebo-controlled-trial-to-evaluate-effects-of-eplerenone-on-metabolic-and-inflammatory-indices-in-hiv
#7
Suman Srinivasa, Kathleen V Fitch, Kimberly Wong, Timothy K O'Malley, Patrick Maehler, Karen L Branch, Sara E Looby, Tricia H Burdo, Edgar L Martinez-Salazar, Martin Torriani, Shannon H Lyons, Julian Weiss, Meghan Feldpausch, Takara L Stanley, Gail K Adler, Steven K Grinspoon
Context: HIV-infected individuals demonstrate unique RAAS physiology, with increased RAAS activation in association with visceral adiposity, insulin resistance, and inflammation. A physiologically-based treatment approach targeting mineralocorticoid receptor (MR) blockade may improve metabolic and inflammatory indices in HIV. Objective: To investigate effects of eplerenone on insulin sensitivity, inflammatory indices and other metabolic parameters in HIV. Design: Six month, double-blind, randomized, placebo-controlled trial...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29651957/serum-uric-acid-elevation-is-associated-to-arterial-stiffness-in-hypertensive-patients-with-metabolic-disturbances
#8
Agustin J Ramirez, Alejandra Ines Christen, Ramiro A Sanchez
INTRODUCTION: Chronic serum uric acid elevation (SUA) is known to be induced by dyslipidemia, hypertension, inflammation, and insulin resistance. Therefore, it has been associated with higher risk for coronary artery disease and cardiovascular mortality. Also, increased levels of SUA have been associated with regional arterial stiffness, assessed by pulse wave velocity (PWV). AIMS: To evaluate the relationships of PWV, SUA and different metabolic parameters in essential hypertensive patients...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651541/monovalerin-and-trivalerin-increase-brain-acetic-acid-decrease-liver-succinic-acid-and-alter-gut-microbiota-in-rats-fed-high-fat-diets
#9
Thao Duy Nguyen, Olena Prykhodko, Frida Fåk Hållenius, Margareta Nyman
PURPOSE: Short-chain fatty acids (SCFA) are known for their anti-inflammatory properties and may also prevent against the development of metabolic diseases. This study investigated possible effects of two valeric acid esters, monovalerin (MV) and trivalerin (TV) in rats fed high-fat diets. METHODS: Four groups of rats were given a low-fat diet (LF) or a high-fat control diet (HFC) with or without supplementation of MV or TV (5 g/kg) for 3 weeks (n = 7/group)...
April 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29650341/the-relation-of-dietary-diversity-score-and-food-insecurity-to-metabolic-syndrome-features-and-glucose-level-among-pre-diabetes-subjects
#10
Farhad Gholizadeh, Jalal Moludi, Ned Lotfi Yagin, Mohammad Alizadeh, Seyed Mostafa Nachvak, Hadi Abdollahzad, Khadijeh Mirzaei, Mostafa Mostafazadeh
INTRODUCTION: Prediabetes is considered as an increased risk factor for cardiovascular disease and overt diabetes and is the precursor stage of diabetes. Dietary Diversity Score (DDS) is recognized as an essential factor of a high-quality diet. However, diets with more varieties of food items might increase calorie intake and body weight. Therefore, this study was carried out to determine the association of DDS with metabolic syndrome features in adults with prediabetes. METHODS: Three hundred subjects were randomly selected from participants who were undergone diabetes test screening program...
April 9, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29650297/n-terminal-pro-b-type-natriuretic-peptide-is-inversely-correlated-with-low-density-lipoprotein-cholesterol-in-the-very-elderly
#11
F Spannella, F Giulietti, G Cocci, L Landi, E Borioni, F E Lombardi, G Rosettani, B Bernardi, V Bordoni, P Giordano, M Bordicchia, R Sarzani
BACKGROUND AND AIMS: Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol. AIM: evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels...
February 27, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29648906/the-effects-of-a-community-based-lifestyle-intervention-on-metabolic-syndrome-and-its-components-in-adolescents-findings-of-a-decade-follow-up
#12
Parisa Amiri, Sara Jalali-Farahani, Hasti Masihay Akbar, Leila Cheraghi, Davood Khalili, Amirabbas Momenan, Parvin Mirmiran, Arash Ghanbarian, Mehdi Hedayati, Firoozeh Hosseini-Esfahani, Fereidoun Azizi
BACKGROUND: The increasing prevalence of metabolic syndrome (MetS) in childhood makes lifestyle interventions imperative during adolescence. This study aimed to assess the effects of a community-based lifestyle intervention on MetS and its components in adolescents. METHODS: Adolescents, based on their residential area were categorized into three groups: complete intervention (residing in the intervention area at baseline and during all follow-ups), incomplete intervention (residing in either the intervention or control areas and were in transition between these two areas), and control group (residing in the control area at baseline and throughout all follow-ups)...
April 12, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29645359/intake-of-fish-alters-the-size-and-composition-of-hdl-particles-and-camelina-sativa-oil-decreases-idl-particle-concentration-in-subjects-with-impaired-glucose-metabolism
#13
Suvi M Manninen, Maria A Lankinen, Vanessa D de Mello, David E Laaksonen, Ursula S Schwab, Arja T Erkkilä
SCOPE: Intake of long-chain n-3 PUFAs affects the lipoprotein subclass profile, whereas the effect of shorter chain n-3 PUFAs remains unclear. We investigated the effect of fish and camelina sativa oil (CSO) intakes on lipoprotein subclasses. METHODS AND RESULTS: Altogether 79 volunteers with impaired glucose metabolism were randomly assigned to CSO, fatty fish (FF), lean fish (LF) or control group for 12 weeks. Nuclear magnetic resonance spectroscopy was used to determine lipoprotein subclasses and their lipid components...
April 12, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29645064/adiponectin-expression-in-visceral-adiposity-is-an-important-determinant-of-insulin-resistance-in-morbid-obesity
#14
Anca Elena Sirbu, Laura Buburuzan, Steliana Kevorkian, Sorina Martin, Carmen Barbu, Catalin Copaescu, Bogdan Smeu, Simona Fica
INTRODUCTION: Visceral adiposity is associated with decreased serum adiponectin levels, peripheral resistance to insulin and an increased risk of cardio-metabolic complications. However, the link between adiponectin expression in visceral adipose tissue (VAT), its serum levels and metabolic protection is controversial. The aim of this study was to investigate the relationship between the adiponectin gene expression in VAT and clinical and metabolic parameters in patients with severe obesity...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29644919/high-neutrophil-lymphocyte-ratio-in-schizophrenia-independent-of-infectious-and-metabolic-parameters
#15
Rabia Nazik Yüksel, Irem Ekmekci Ertek, Asiye Uğraş Dikmen, Erol Göka
BACKGROUND: Immunological and inflammatory mechanisms play an important role in schizophrenia. In the literature, there are studies investigating neutrophil-lymphocyte ratio (NLR) association with schizophrenia. AIMS: The purpose of this study was to compare NLR values between patients with schizophrenia and healthy controls. In addition, the study aimed to investigate the relationship between NLR and disease severity and some metabolic/inflammatory parameters. METHODS: Fifty-two patients diagnosed with schzophrenia and 53 healthy controls were included in the study...
April 12, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29643920/mir-33-inhibition-attenuates-the-effect-of-liver-x-receptor-agonist-t0901317-on-expression-of-liver-x-receptor-alpha-in-mice-liver
#16
Abbas Mohammadi, Hossein Fallah, Beydolah Shahouzehi, Hamid Najafipour
BACKGROUND: microRNAs play pivotal roles in metabolism and other aspects of cell biology. microRNA-33 and liver X receptor (LXR) affect lipid metabolism and cholesterol trafficking. In this study, we evaluated effects of co-administration of miR-33 inhibitor and LXR activator on LXR-α and adenosine triphosphate-binding cassette transporter A1 (ABCA1) expression in mice liver. METHODS: Twenty-four mice were randomly allocated into four groups (n = 6). Group 1 mice received standard chow diet without any treatment, group 2 received 30 mg/kg/48 hour LXR agonist (T0901317), group 3 received 1 mg/kg/48 hour in vivo locked nucleic acids (LNA) anti-miR-33 and group 4 received both T0901317 and in vivo LNA anti-miR-33...
November 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29643166/metabolic-syndrome-and-its-components-with-neuron-specific-enolase-a-cross-sectional-study-in-large-health-check-up-population-in-china
#17
Shu-Yi Wang, Xiao-Juan Zha, Xin-Ying Zhu, Wen-Bo Li, Jun Ma, Ze-Wei Wu, Huan Wu, Ming-Fei Jiang, Yu-Feng Wen
OBJECTIVE: This study was aimed at investigating the relationship between neuron-specific enolase (NSE) and components of metabolic syndrome (MS). DESIGN: Cross-sectional study. SETTING: Chinese health check-up population. PARTICIPANTS: 40 684 health check-up people were enrolled in this study from year 2014 to 2016. MAIN OUTCOME MEASURES: OR and coefficient for MS. RESULTS: The percentage of abnormal NSE and MS was 26...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29628896/inflammatory-and-metabolic-responses-to-different-resistance-training-on-chronic-obstructive-pulmonary-disease-a-randomized-control-trial
#18
Bruna S de Alencar Silva, Fábio S Lira, Fabrício E Rossi, Dionei Ramos, Juliana S Uzeloto, Ana P C F Freire, Fabiano F de Lima, Luís A Gobbo, Ercy M C Ramos
Background: Low-grade inflammation can be present in chronic obstructive pulmonary disease (COPD), which may affect the regulation of muscle protein and body metabolism. Regular exercise show improvement in muscle strength and dyspnea in patients with COPD, however, the response to training on inflammatory and metabolic disorders is unclear. In this study, we compared the effects of resistance training using weight machines and elastic resistance (bands and tubes) on the inflammatory and metabolic responses in patients with COPD...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29628482/relationship-between-long-interspersed-nuclear-element-1-dna-methylation-in-leukocytes-and-dyslipidemia-in-the-japanese-general-population
#19
Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yuri Murase, Koji Ohashi, Hiroaki Ishikawa, Mari Kondo, Takashi Inoue, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
AIM: Aberrant global DNA methylation is involved in the development of several diseases, including cardiovascular disease (CVD). We investigated whether the methylation of long interspersed nuclear element-1 (LINE-1) in leukocytes is associated with dyslipidemia, a major risk factor for CVD, in the Japanese general population. METHODS: We conducted a cross-sectional study consisting of 420 Japanese subjects (187 men and 233 women) without a clinical history of cancer, stroke, or ischemic heart disease...
April 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#20
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
March 9, 2018: Journal of Clinical Lipidology
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