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https://www.readbyqxmd.com/read/29660507/does-semiology-of-status-epilepticus-have-an-impact-on-treatment-response-and-outcome
#1
Leyla Baysal-Kirac, Berend Feddersen, Marion Einhellig, Jan Rémi, Soheyl Noachtar
OBJECTIVE: This study investigated whether there is an association between semiology of status epilepticus (SE) and response to treatment and outcome. METHOD: Two hundred ninety-eight consecutive adult patients (160 females, 138 males) with SE at the University of Munich Hospital were prospectively enrolled. Mean age was 63.2±17.5 (18-97) years. Patient demographics, SE semiology and electroencephalography (EEG) findings, etiology, duration of SE, treatment, and outcome measures were investigated...
April 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29650639/non-convulsive-status-epilepticus-mimics-and-chameleons
#2
REVIEW
Michael Owen Kinney, John J Craig, P W Kaplan
Non-convulsive status epilepticus (NCSE) is an enigmatic condition with protean manifestations. It often goes unrecognised, leading to delays in its diagnosis and treatment. The principal reason for such delay is the failure to consider and request an electroencephalogram (EEG), although occasional presentations have no scalp or surface electroencephalographic correlate. In certain settings with limited EEG availability, particularly out-of-hours, clinicians should consider treating without an EEG. Patients need a careful risk-benefit analysis to assess the risks of neuronal damage and harm versus the risks of adverse effects from various intensities of therapeutic intervention...
April 12, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29597185/diazepam-for-outpatient-treatment-of-nonconvulsive-status-epilepticus-in-pediatric-patients-with-angelman-syndrome
#3
Lila Worden, Olivia Grocott, Amanda Tourjee, Fonda Chan, Ronald Thibert
Nonconvulsive status epilepticus (NCSE) is present in multiple pediatric neurogenetic syndromes with epileptic encephalopathies. While intravenous (IV) medications are used inpatient for treatment of critical illness-related NCSE, there is no consensus on treatment of ambulatory NCSE. Up to 50% of patients with Angelman syndrome (AS) have NCSE with myoclonic or atypical absence status. Here we report our experience in pediatric patients with AS and NCSE treated outpatient with a tapering course of oral diazepam...
March 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29588978/topography-of-generalized-periodic-epileptiform-discharges-in-postanoxic-nonconvulsive-status-epilepticus
#4
Dimitris Fotis Sakellariou, George Kostantinos Kostopoulos, Mark Philip Richardson, Michalis Koutroumanidis
We studied slow (≤2.5 Hz) nonevolving generalized periodic epileptiform discharges (GPEDs) in the electroencephalogram (EEG) of comatose patients after cardiac arrest (CA) in search of evidence that could assist early diagnosis of possible hypoxic nonconvulsive status epilepticus (NCSE) and its differentiation from terminal brain anoxia (BA), which can present with a similar EEG pattern. We investigated the topography of the GPEDs in the first post-CA EEGs of 13 patients, using voltage-mapping, and compared findings between two patients with NCSE and GPEDs > 2...
December 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29587188/nonconvulsive-status-epilepticus-after-cessation-of-convulsive-status-epilepticus-in-pediatric-intensive-care-unit-patients
#5
Jin Chen, Lingling Xie, Yue Hu, Xinghui Lan, Li Jiang
Little is known about pediatric patients suffering from nonconvulsive status epilepticus (NCSE) after convulsive status epilepticus (CSE) cessation. The aim of this study was to identify in pediatric patients the clinical characteristics of NCSE after CSE cessation and the factors that contribute to patient outcomes. Data from clinical features, electroencephalography (EEG) characteristics, neuroimaging findings, treatments, and prognosis were systematically summarized, and the associations between clinical characteristics and prognosis were quantified...
March 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29574298/the-relevance-of-timing-in-nonconvulsive-status-epilepticus-a-series-of-38-cases
#6
Álvaro Gutiérrez-Viedma, Beatriz Parejo-Carbonell, María-Luz Cuadrado, Irene Serrano-García, Belén Abarrategui, Irene García-Morales
BACKGROUND: Timing in the management of nonconvulsive status epilepticus (NCSE) seems to be one of the most important modifiable prognostic factors. We aimed to determine the precise relationship between timing in NCSE management and its outcome. METHODS: We performed a cross-sectional study in which clinical data were prospectively obtained from all consecutive adults with NCSE admitted to our hospital from 2014 to 2016. Univariate and multivariable regression analyses were performed to identify clinical and timing variables associated with NCSE prognosis...
March 22, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29555354/nonconvulsive-status-epilepticus-after-convulsive-status-epilepticus-clinical-features-outcomes-and-prognostic-factors
#7
Fang Yuan, Fang Yang, Wen Li, Xiai Yang, Qiong Gao, Lijie Bi, Yongli Jiang, Wen Jiang
OBJECTIVES: To investigate clinical characteristics and outcomes of nonconvulsive status epilepticus (NCSE) after convulsive status epilepticus (CSE) and determine risk factors for unfavorable outcomes. METHODS: We reviewed consecutive patients with NCSE after CSE over eight years in the neurological intensive care unit. Clinical presentations and the Salzburg EEG criteria for NCSE were used to identify patients with NCSE after CSE. Demographics, clinical features, and anti-epileptic treatment responses were collected and analyzed...
March 12, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29542918/pseudohalide-tectons-within-the-coordination-sphere-of-the-uranyl-ion-experimental-and-theoretical-study-of-c-h%C3%A2-%C3%A2-%C3%A2-o-c-h%C3%A2-%C3%A2-%C3%A2-s-and-chalcogenide-noncovalent-interactions
#8
Stefano Nuzzo, Brendan Twamley, James A Platts, Robert J Baker
A series of uranyl thiocyanate and selenocyanate of the type [R4 N]3 [UO2 (NCS)5 ] (R4 =n Bu4 , Me3 Bz, Et3 Bz), [Ph4 P][UO2 (NCS)3 (NO3 )] and [R4 N]3 [UO2 (NCSe)5 ] (R4 = Me4 ,n Pr4 , Et3 Bz) have been prepared and structurally characterized. The resulting noncovalent interactions have been examined and compared to other examples in the literature. The nature of these interactions is determined by the cation so that when the alkyl groups are small, chalcogenide···chalcogenide interactions are present, but this "switches off" when R =n Pr and charge assisted U═O···H-C and S(e)···H-C hydrogen bonding remain the dominant interaction...
March 15, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29485878/isoselenocyanates-versus-isothiocyanates-and-isocyanates
#9
Anna Chrostowska, Clovis Darrigan, Alain Dargelos, Alain Graciaa, Jean-Claude Guillemin
Alkyl and aryl isoselenocyanates are well-known intermediates in the synthesis of various organoselenium compounds but the knowledge of the physicochemical properties of simple unsaturated derivatives is still fragmentary. Vinyl-, 2-propenyl- and cyclopropyl isoselenocyanates have been prepared by reaction of selenium in powder with the corresponding isocyanides. The isoselenocyanates of this series, with a variable distance between the N=C=Se group and the unsaturated or pseudo-unsaturated group, have been studied by UV-photoelectron spectroscopy and quantum chemical calculations...
February 27, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29462742/refractory-status-epilepticus-impact-of-baseline-comorbidity-and-usefulness-of-stess-and-emse-scoring-systems-in-predicting-mortality-and-functional-outcome
#10
Jordi Ciurans, Laia Grau-López, Marta Jiménez, Alejandra Fumanal, Maite Misis, Juan Luis Becerra
PURPOSE: Little has been published on the prognostic value of the Status Epilepticus Severity Score (STESS) or the Epidemiology-based Mortality score in Status Epilepticus (EMSE) in refractory status epilepticus (RSE). We sought to analyze the prognostic value of STESS and EMSE and the impact of baseline comorbidities in mortality and functional outcome in RSE. METHODS: We designed an observational retrospective study of patients diagnosed with RSE between August 2013 and September 2017...
February 12, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29459611/non-convulsive-status-epilepticus-in-children-clinical-profile-eeg-characteristics-and-treatment
#11
K Fatema, M M Rahman, S Akhter, N Akter, S Begum
Non-convulsive status epilepticus (NCSE) is a term used to denote a range of conditions in which electrographic seizure activity is prolonged and results in non-convulsive clinical symptoms. This study was done to describe the clinical spectrum, EEG findings and to evaluate the efficacy of different therapeutic agents in children with NCSE in 33 patients from January 2011 to December 2015 period. All patients had EEG before and after treatment. Age range was 6 months to 14 year, 25 were male. Regarding development status, 48% had developmental delay, 21% had normal development, 9% had regression and 21% had both developmental delay and regression...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29455222/encephalopathy-mimicking-non-convulsive-status-epilepticus
#12
Ramachandiran Nandhagopal, Fathiya Al-Murshedi, Mujahid Al-Busaidi, Amna Al-Busaidi
Primary hyperammonemic encephalopathy due to urea cycle disorders (UCD) typically manifests with episodic unresponsiveness and this clinical entity is not often included in the differential diagnosis of presumed non-convulsive status epilepticus (NCSE). However, this diagnostic consideration has therapeutic implications. In this report, we document the therapeutic importance of elucidating the specific cause of hyperammonemic encephalopathy that closely mimicked NCSE through 2 unique illustrative cases.
January 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29455141/comparison-of-scoring-tools-for-the-prediction-of-in-hospital-mortality-in-status-epilepticus
#13
Caroline Reindl, Ruben U Knappe, Maximilian I Sprügel, Jochen A Sembill, Tamara M Mueller, Hajo M Hamer, Hagen B Huttner, Dominik Madžar
PURPOSE: Several scoring tools have been developed for the prognostication of outcome after status epilepticus (SE). In this study, we compared the performances of STESS (Status Epilepticus Severity Score), mSTESS (modified STESS), EMSE-EAL (Epidemiology-based Mortality Score in Status Epilepticus- Etiology, Age, Level of Consciousness) and END-IT (Encephalitis-NCSE-Diazepam resistance-Image abnormalities-Tracheal intubation) in predicting in-hospital mortality after SE. METHOD: Data collected retrospectively from a cohort of 287 patients with SE were used to calculate STESS, mSTESS, EMSE-EAL, and END-IT scores...
February 1, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29443785/can-endotracheal-intubation-be-the-first-step-in-management-of-nonconvulsive-status-epilepticus-a-case-report
#14
Saad Warraich, Abbas Ali, Atif Nizami, Moiz Bakhiet
RATIONALE: Nonconvulsive status epilepticus (NCSE) is prolonged seizure activity without motor manifestations. Clinically, there are certain examination findings, in addition to elements of history, that help differentiate it from other encephalopathies. When diagnosing NCSE, the physician faces significant difficulties due to inconsistent clinical presentation and somewhat nonspecific electroencephalogram (EEG) criteria. PATIENT CONCERNS: To highlight the problems faced when dealing with such a patient, a case of a 29-year-old male who presented with an altered state of consciousness is put forth for the reader...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29414555/specificity-of-electroclinical-features-in-the-diagnosis-of-ring-chromosome-20
#15
A B Gago-Veiga, R Toledano, I García-Morales, M A Pérez-Jiménez, J Bernar, A Gil-Nagel
BACKGROUND: Ring chromosome 20 (R20) syndrome is a chromosomal disorder characterized mainly by drug-resistant frontal lobe seizures, recurrent nonconvulsive status epilepticus (NCSE), and typical EEG features. The aim of this study was to investigate if this triad is common and specific to all patients with R20. METHODS: In this cross-sectional study (from 2000 to 2011), we selected patients who fulfilled at least two out of three criteria: drug-resistant frontal lobe seizures, recurrent NCSE, and characteristic electroencephalography (EEG) features...
February 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29344469/successful-use-of-therapeutic-hypothermia-for-refractory-nonconvulsive-status-epilepticus
#16
Do-Hyung Kim, Hye-Hoon Kang, Minjung Kim, Tae-Won Yang, Oh-Young Kwon, Jung Sook Yeom, Bong Su Kang, Yong Hwan Kim, Young-Soo Kim
Therapeutic hypothermia (TH) has rarely been utilized as an adjunct to anticonvulsants in treating patients with refractory convulsive status epilepticus (CSE). However, determining the effectiveness of TH in CSE is difficult due to the unavoidable use of sedative drugs to manage hypothermia. Additionally, the effectiveness of TH has not been studied in patients with refractory non-convulsive status epilepticus (NCSE). Here, we report the successful use of TH without additional sedative drugs in a patient with temporal lobe epilepsy and refractory NCSE...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29322820/reevaluation-of-the-critically-ill-patients-with-nonconvulsive-status-epilepticus-by-using-salzburg-consensus-criteria
#17
Ozlem Gungor Tuncer, Ebru Altindag, Sevda Ozel Yildiz, Mecbure Nalbantoglu, Mehmet Eren Acik, Sedef Tavukcu Ozkan, Betul Baykan
OBJECTIVE: We aimed to assess the usefulness of the Salzburg Consensus Criteria (SCC) for determining the prognosis of critically ill patients with nonconvulsive status epilepticus (NCSE). METHODS: We retrospectively reviewed consecutive patients with unconsciousness followed up in the intensive care unit (ICU). Three clinical neurophysiologists, one of them blinded to clinical and laboratory data, reevaluated all EEG data independently and determined NCSE according to SCC...
January 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29313552/effect-of-linear-and-non-linear-pseudohalides-on-the-structural-and-magnetic-properties-of-co-ii-hexacoordinate-single-molecule-magnets
#18
L Váhovská, S Vitushkina, I Potočňák, Z Trávníček, R Herchel
A series of mononuclear hexacoordinate Co(ii) complexes with the 4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole (abpt) ligand and various linear and non-linear pseudohalides, such as NCSe (selenocyanate), N{C(CN)2 }2 (1,1,3,3-tetracyano-2-azapropenide, tcap), NO2 C(CN)2 (nitrodicyanomethanide, nodcm), C(CN){C(CN)2 }2 (1,1,2,3,3-pentacyanopropenide, pcp), NO2 NCN (nitrocyanamide, nca), and ONC(CN)2 (nitrosodicyanomethanide, ndcm), was prepared. X-ray analyses revealed the formation of the complexes with the general compositions [Co(abpt)2 (solv)2 ]X2 (solv = H2 O and X = tcap (1), solv = H2 O and X = nodcm (2), solv = CH3 OH and X = pcp (3)) or [Co(abpt)2 (X)2 ] (X = nca (4), X = NCSe (5), X = ndcm (6))...
January 30, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29262437/ictal-interictal-continuum-when-to-worry-about-the-continuous-electroencephalography-pattern
#19
Justine Cormier, Carolina B Maciel, Emily J Gilmore
Continuous electroencephalography (cEEG) monitoring is an invaluable tool in the evaluation of encephalopathy and coma in critically ill patients. Marked increases in cEEG monitoring, coinciding with several societal guideline statements in the last decade, have allowed earlier detection and treatment of clearly harmful patterns, including nonconvulsive seizures (NCSz) and nonconvulsive status epilepticus (NCSE). However, it has also unmasked a range of EEG patterns of less clear clinical significance, with some more "malignant" than others given their potential association with increased neuronal stress and secondary brain injury...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29260591/subacute-encephalopathy-with-seizures-in-alcoholics-sesa-presenting-as-focal-nonconvulsive-status-epilepticus
#20
Peter W Kaplan, Andrew Billnitzer, José Luis Fernández-Torre
PURPOSE: To acquaint readers with the underrecognized subacute encephalopathy with seizures in chronic alcoholics (SESA) that has more recently been associated with different types of status epilepticus. METHODS: Case reports and review of the literature on SESA and nonconvulsive status epilepticus (NCSE). RESULTS: Two cases: one with alternating bifrontoparietal NCSE, and one with focal, confusional NCSE, with imaging and EEG correlates. CONCLUSION: Underrecognized SESA may present as NCSE with focal clinical, EEG and reversible diffusion-weighted MRI abnormalities, warranting expedited diagnosis and antiseizure treatment to minimize morbidity...
December 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
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