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F Giesche, H Streicher, M Maiwald, P Wagner
INTRODUCTION: The medical and healthcare economic burden caused by chronic lumbar back pain (CLBP) requires the use of interdisciplinary treatment approaches. The present study aimed to evaluate whether the effectiveness of inpatient multimodal pain therapy (MPT, operations and procedures (OPS) coding 8-918.02), can be increased by implementing additional neuromuscular core stability exercises (NCSE). MATERIAL AND METHODS: As part of a prospective controlled study, subjects with CLBP (n = 48, 17 males, 58...
December 2, 2016: Der Schmerz
Jun-Li Wang, Qiang Liu, Xiao-Jin Lv, Rui-Lin Wang, Chun-Ying Duan, Tao Liu
The rational design of magnetic and fluorescent bifunctional materials is attracting increasing interest. In this study, two mononuclear Fe(ii) complexes, namely [Fe(L)2(NCS)2] (1) and [Fe(L)2(NCSe)2] (2) are synthesised by combining a spin-crossover unit and a fluorescent ligand (naphth-1-yl)-N-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)methanimine (L) to achieve bifunctionality. Single-crystal X-ray studies and magnetic measurements confirm the presence of spin crossover behaviours; these measurements agree with the results of the temperature depended Raman spectra and infrared spectra...
November 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Alexandra Rohracher, Doris P Reiter, Francesco Brigo, Gudrun Kalss, Aljoscha Thomschewski, Helmut Novak, Alexander Zerbs, Judith Dobesberger, Aynur Akhundova, Julia Höfler, Giorgi Kuchukhidze, Markus Leitinger, Eugen Trinka
PURPOSE: Status epilepticus (SE) is one of the most common neurological emergencies with a high incidence in the elderly. Major determinants of prognosis are patients' age, duration of SE and underlying etiology. We aimed identifying differences in clinical presentation of SE, etiologies and outcome between patients (pts.) sixty years or older (≥60) and younger than sixty (<60) years (yrs). METHODS: We retrospectively analyzed 120 patients (48 women) with SE admitted to the Neurological Intensive Care Unit (NICU), Department of Neurology, Paracelsus Medical University Salzburg, Austria between 1/2011 and 01/2013...
November 2016: Epilepsy Research
Yuichi Kubota, Hidetoshi Nakamoto, Takakazu Kawamata
Herein, we review the current state of nonconvulsive status epilepticus (NCSE). NCSE has recently been recognized as one of the causes of unexplained impaired consciousness in the neurosurgical or neurocritical setting. The causes of NCSE include not only central nervous system disorders such as craniotomy, stroke, traumatic brain injury, and central nervous system inflammation, but also severe critical conditions such as sepsis and uremia, among others. NCSE shows no overt clinical manifestations; therefore, prompt and correct diagnosis is difficult...
October 15, 2016: Neurologia Medico-chirurgica
Markus Leitinger, Eugen Trinka, Elena Gardella, Alexandra Rohracher, Gudrun Kalss, Erisela Qerama, Julia Höfler, Alexander Hess, Georg Zimmermann, Giorgi Kuchukhidze, Judith Dobesberger, Patrick B Langthaler, Sándor Beniczky
BACKGROUND: Several EEG criteria have been proposed for diagnosis of non-convulsive status epilepticus (NCSE), but none have been clinically validated. We aimed to assess the diagnostic accuracy of the EEG criteria proposed by a panel of experts at the fourth London-Innsbruck Colloquium on Status Epilepticus in Salzburg, 2013 (henceforth called the Salzburg criteria). METHODS: We did a retrospective, diagnostic accuracy study using EEG recordings from patients admitted for neurological symptoms or signs to three centres in two countries (Danish Epilepsy Centre, Dianalund, Denmark; Aarhus University Hospital, Aarhus, Denmark; and Paracelsus Medical University, Salzburg, Austria)...
September 2016: Lancet Neurology
Kjersti Nesheim Power, Arne Gramstad, Nils Erik Gilhus, Bernt A Engelsen
AIM: Status epilepticus (SE) can lead to sequelae or even death. Identifying characteristics associated with poor outcome is crucial in guiding patient treatment. Based on our retrospective patient cohorts, potential prognostic factors were analysed. METHODS: Patients consecutively treated for refractory convulsive status epilepticus (CSE) between 2001 and 2010 and non-convulsive status epilepticus (NCSE) between 2004 and 2009 were studied. Outcome was compared to prognostic variables...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
Rajeev Kumar Verma, Eugenio Abela, Kaspar Schindler, Heinz Krestel, Elisabeth Springer, Adrian Huber, Christian Weisstanner, Martinus Hauf, Jan Gralla, Roland Wiest
OBJECTIVE: The aim of this study was to investigate variant patterns of cortical venous oxygenation during status epilepticus (SE) using susceptibility-weighted imaging (SWI). METHODS: We analyzed magnetic resonance imaging (MRI) scans of 26 patients with clinically witnessed prolonged seizures and/or EEG-confirmed SE. All MRI exams encompassed SWI, dynamic susceptibility contrast perfusion MRI (MRI-DSC) and diffusion-weighted imaging (DWI). We aimed to identify distinct patterns of SWI signal alterations that revealed regional or global increases of cerebral blood flow (CBF) and DWI restrictions...
2016: PloS One
J U Máñez Miró, F J Díaz de Terán, P Alonso Singer, M J Aguilar-Amat Prior
INTRODUCTION: We aim to describe the use of emergency electroencephalogram (EmEEG) by the on-call neurologist when nonconvulsive status epilepticus (NCSE) is suspected, and in other indications, in a tertiary hospital. SUBJECTS AND METHODS: Observational retrospective cohort study of emergency EEG (EmEEG) recordings with 8-channel systems performed and analysed by the on-call neurologist in the emergency department and in-hospital wards between July 2013 and May 2015...
July 19, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Ibrahim Bora, Aylin Bican Demir, Pinar Uzun
Cephalosporins, particularly cefepime, exert neurotoxic side effects that can lead to status epilepticus. These neurotoxic side effects include myoclonus, dystonic movements, tremor, asterixis, seizure, status epilepticus, encephalopathy, and sometimes coma. Status epilepticus, particularly nonconvulsive status epilepticus (NCSE), is a well-known but unusual complication in patients with altered renal function who were receiving treatment with intravenous cephalosporins, especially cefepime. We reviewed the clinical and electroencephalographic (EEG) characteristics of 7 patients with renal failure who developed consciousness alterations with changes in EEG activity while being treated with cephalosporins...
2016: Epilepsy & Behavior Case Reports
Hoi Ki Kate Lui, Kwok Fai Hui, Wing Chi Fong, Chun Tak Ip, Hiu Tung Colin Lui
PURPOSE: To identify predictors of poor clinical outcome in patients presenting to the intensive care units with status epilepticus (SE), in particular for patients presenting with de novo status epileptics. METHODS: A retrospective review was performed on patients admitted to the intensive care units with status epilepticus in two hospitals in Hong Kong over an 11-year period from 2003 to 2013. RESULTS: A total of 87 SE cases were analyzed...
August 2016: Seizure: the Journal of the British Epilepsy Association
Alejandra Arroyave, Anders Lennartson, Alina Dragulescu-Andrasi, Kasper S Pedersen, Stergios Piligkos, Sebastian A Stoian, Samuel M Greer, Chongin Pak, Oleksandr Hietsoi, Hoa Phan, Stephen Hill, Christine J McKenzie, Michael Shatruk
Reactions of Fe(II) precursors with the tetradentate ligand S,S'-bis(2-pyridylmethyl)-1,2-thioethane (bpte) and monodentate NCE(-) coligands afforded mononuclear complexes [Fe(bpte)(NCE)2] (1, E = S; 2, E = Se; 3, E = BH3) that exhibit temperature-induced spin crossover (SCO). As the ligand field strength increases from NCS(-) to NCSe(-) to NCBH3(-), the SCO shifts to higher temperatures. Complex 1 exhibits only a partial (15%) conversion from the high-spin (HS) to the low-spin (LS) state, with an onset around 100 K...
June 20, 2016: Inorganic Chemistry
Rob Forsyth, Tim Martland, Ming Lai, Gayatri Vadlamani, Vanessa Hogan
OBJECTIVE: To establish the efficacy and tolerability of inhaled 5% carbon dioxide/95% oxygen as a treatment for paediatric non-convulsive status epilepticus (NCSE). METHODS: In an open label clinical trial, children in NCSE were given high flow inhaled 5% carbon dioxide/95% oxygen by face mask for 120 s under EEG control. RESULTS: Six children (five male; ages 3-13; all with severe underlying epilepsy and disability) were recruited. Inhalation was well tolerated in all cases...
July 2016: European Journal of Paediatric Neurology: EJPN
Raoul Sutter, Saskia Semmlack, Peter W Kaplan
Nonconvulsive status epilepticus (NCSE) is a state of continuous or repetitive seizures without convulsions. Owing to the nonspecific symptoms and considerable morbidity and mortality associated with NCSE, clinical research has focused on early diagnosis, risk stratification and seizure termination. The subtle symptoms and the necessity for electroencephalographic confirmation of seizures result in under-diagnosis with deleterious consequences. The introduction of continuous EEG to clinical practice, and the characterization of electrographic criteria have delineated a number of NCSE types that are associated with different prognoses in several clinical settings...
May 2016: Nature Reviews. Neurology
Masahiro Mizobuchi
Nonconvulsive status epilepticus (NCSE) is a type of status epilepticus (SE) lacking a predominant motor manifestation. The annual prevalence of NCSE is estimated to reach 10 to 20 cases in every 100,000 people. While almost half of all SE cases are nonconvulsive, there are several different types of NCSE: 1) epileptic absence SE, 2) epileptic focal seizure SE with consciousness disturbance (complex partial SE), 3) de novo NCSE of late onset, 4) NCSE due to acute brain injury or prolonged consciousness disturbance after convulsive SE...
April 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
Hiroshi Yamaguchi, Tsukasa Tanaka, Azusa Maruyama, Hiroaki Nagase
Infection, whether viral or bacterial, can result in various forms of brain dysfunction (encephalopathy). Septic encephalopathy (SE) is caused by an excessive immune reaction to infection, with clinical features including disturbed consciousness and seizures. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is usually accompanied by viral infection in children and is characterized by biphasic seizures and impaired consciousness. The initial neurologic symptom of AESD is typically a febrile seizure that frequently lasts longer than 30 minutes...
2016: Case Reports in Neurological Medicine
Eve Chanson, Élodie Bicilli, Michel Lauxerois, Sophie Kauffmann, Russell Chabanne, François Ducray, Jérome Honnorat, Pierre Clavelou, Sarah Rosenberg
Seizures are common clinical manifestations in anti-N-methyl-d-aspartate receptor (anti-NMDA-R) encephalitis, among other neurological and psychiatric symptoms. During the course of the disease, some specific EEG patterns have been described: generalized rhythmic delta activity (GRDA) and extreme delta brush (EDB). In comatose patients, the association of these EEG abnormalities with subtle motor manifestations can suggest ongoing non-convulsive status epilepticus (NCSE). We report the case of a 28-year-old woman admitted for a clinical presentation typical of anti-NMDA-R encephalitis, which was confirmed by CSF analysis...
February 2016: Neurophysiologie Clinique, Clinical Neurophysiology
Eric H Grover, Yara Nazzal, Lawrence J Hirsch
Convulsive status epilepticus (CSE) is a medical emergency with an associated high mortality and morbidity. It is defined as a convulsive seizure lasting more than 5 min or consecutive seizures without recovery of consciousness. Successful management of CSE depends on rapid administration of adequate doses of anti-epileptic drugs (AEDs). The exact choice of AED is less important than rapid treatment and early consideration of reversible etiologies. Current guidelines recommend the use of benzodiazepines (BNZ) as first-line treatment in CSE...
March 2016: Current Treatment Options in Neurology
Mouhamadou Sy, Damien Garrot, Ahmed Slimani, Miguel Páez-Espejo, François Varret, Kamel Boukheddaden
By using a weak modulated laser intensity we have succeeded in reversibly controlling the dynamics of the spin-crossover (SC) single crystal [{Fe(NCSe)(py)2 }2 (m-bpypz)] inside the thermal hysteresis. The experiment could be repeated several times with a reproducible response of the high-spin low-spin interface and without crystal damage. In-depth investigations as a function of the amplitude and frequency of the excitation brought to light the existence of a cut-off frequency ca. 1.5 Hz. The results not only document the applicability of SC materials as actuators, memory devices, or switches, but also open a new avenue for the reversible photo-control of the spin transition inside the thermal hysteresis...
January 26, 2016: Angewandte Chemie
Xiaoping Kang, Hong Jiang, Chunbo Wu, Xianzeng Liu, Jun Qiang, Fang Liu, Yang Guo, Danqing Xiao, Jingyi Liu, Jing Yu, Xuguang Gao, Youzhong An, Jihong Zhu, Fengxue Zhu
OBJECTIVE: To evaluate the application value of continuous video-electroencephalographic (cVEEG) monitoring in patients with consciousness disorders in intensive care unit (ICU). METHODS: Retrospective analyses were conducted for applying cVEEG in the clinical diagnosis and outcome evaluation of 54 patients with consciousness disorders in intensive care unit (ICU) at our hospital from January 2008 to April 2014. RESULTS: The most common cause was cerebrovascular disease (46...
June 2, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
A Suarez-de-la-Rica, C Hernández-Gancedo, A López-Tofiño, E Maseda, F Gilsanz
Neurotoxicity caused by cefepime may occur predominantly in patients with impaired renal function. A case of a cefepime-induced non-convulsive status epilepticus (NCSE) is presented. A 65-year-old woman suffered a severe NCSE due to cefepime in the presence of acute renal failure, requiring coma induction with sodium thiopental. A serious interaction between valproic acid (VPA) and meropenem was also produced after changing cefepime to meropenem. Continuous veno-venous haemofiltration was employed to improve cefepime clearance, and the patient progressively regained her previous mental condition...
June 2016: Revista Española de Anestesiología y Reanimación
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