keyword
https://read.qxmd.com/read/37712618/cost-effectiveness-analysis-of-bimekizumab-for-the-treatment-of-active-psoriatic-arthritis-in-sweden
#21
JOURNAL ARTICLE
Valgerdur Sigurdardottir, Anna Engstrom, Patric Berling, Tor Olofsson, Linnea Oldsberg, Susannah Sadler, Devian Parra-Padilla, Lode Melis, Damon Willems
AIMS: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. MATERIALS AND METHODS: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibitor experienced [TNFi-exp] PsA patients over a lifetime horizon...
2023: Journal of Medical Economics
https://read.qxmd.com/read/37704017/clinical-review-of-human-mpox
#22
REVIEW
Dimie Ogoina, Inger Damon, Emmanuel Nakoune
BACKGROUND: Historically, human mpox was predominantly a zoonotic disease occurring more frequently in rural children in Africa and characterized by a largely self-limiting febrile centrifugal monomorphic rash illness. However, the 2022 mpox global outbreak has shown that the disease is changing in many ways, including sustained human-to-human transmission via sexual contact, novel clinical presentations, and adverse associations between mpox and advanced HIV. OBJECTIVES: The aim of this paper is to review the traditional and emerging clinical aspects of human mpox and provide updated information on the clinical course and outcome of the disease...
September 11, 2023: Clinical Microbiology and Infection
https://read.qxmd.com/read/37674605/incisors-bone-height-and-inclination-changes-after-orthodontic-treatment-with-a-self-ligating-passive-system
#23
JOURNAL ARTICLE
Célia-Regina-Maio Pinzan-Vercelino, Karina-Maria-Salvatore Freitas, Monique Secco, Arnaldo Pinzan, Paula Cotrin, Fabricio-Pinelli Valarelli, Guilherme Janson, Marcos-Roberto Freitas
BACKGROUND: This study aimed to evaluate changes in the alveolar buccal bone height of maxillary and mandibular incisors after orthodontic treatment with a self-ligating passive system and to assess the correlation between bone height and incisor inclination. MATERIAL AND METHODS: Pre (T1) and post-treatment (T2) cone-beam computed tomography images of patients treated with the Damon 3MX appliance system were measured to quantify the alveolar buccal bone height of the maxillary incisors...
August 2023: Journal of Clinical and Experimental Dentistry
https://read.qxmd.com/read/37639535/clinical-neurology-in-practice-the-tongue-part-1
#24
JOURNAL ARTICLE
Stéphane Mathis, Guilhem Solé, Nathalie Damon-Perrière, Marie Rouanet-Larrivière, Fanny Duval, Julia Prigent, Louis Nadal, Yann Péréon, Gwendal Le Masson
BACKGROUND: The tongue is an essential organ for the development of certain crucial functions, such as swallowing and language. The examination of the tongue can be very useful in neurology, as the various types of lingual alterations can lead to certain specific diagnoses, the tongue being a kind of "mirror" of some neurological function. REVIEW SUMMARY: In this study, we reviewed the literature on anatomy, physiology, and the various aspects of the examination of the tongue...
August 25, 2023: Neurologist
https://read.qxmd.com/read/37639532/clinical-neurology-in-practice-the-tongue-part-2
#25
JOURNAL ARTICLE
Stéphane Mathis, Guilhem Solé, Nathalie Damon-Perrière, Marie Rouanet-Larrivière, Fanny Duval, Julia Prigent, Louis Nadal, Yann Péréon, Gwendal Le Masson
BACKGROUND: The tongue is an essential organ for the development of certain crucial functions such as swallowing and speech. The examination of the tongue can be very useful in neurology, as the various types of lingual alterations can lead to certain specific diagnoses, the tongue being a kind of 'mirror' of some neurological function. REVIEW SUMMARY: To discuss the elements of clinical examination of the tongue in relation to neurological disorders. After reviewing the different superficial lesions of the tongue, we deal with various movement disorders of the tongue (fasciculations/myokimia, orolingual tremor, choreic movements of the tongue, dystonia of the tongue, lingual myoclonus, and psychogenic movements), disorders of taste and lingual sensitivity and lingual pain...
August 25, 2023: Neurologist
https://read.qxmd.com/read/37317984/epitaxially-driven-phase-selectivity-of-sn-in-hybrid-quantum-nanowires
#26
JOURNAL ARTICLE
Sabbir A Khan, Sara Martí-Sánchez, Dags Olsteins, Charalampos Lampadaris, Damon James Carrad, Yu Liu, Judith Quiñones, Maria Chiara Spadaro, Thomas Sand Jespersen, Peter Krogstrup, Jordi Arbiol
Hybrid semiconductor-superconductor nanowires constitute a pervasive platform for studying gate-tunable superconductivity and the emergence of topological behavior. Their low dimensionality and crystal structure flexibility facilitate unique heterostructure growth and efficient material optimization, crucial prerequisites for accurately constructing complex multicomponent quantum materials. Here, we present an extensive study of Sn growth on InSb, InAsSb, and InAs nanowires and demonstrate how the crystal structure of the nanowires drives the formation of either semimetallic α-Sn or superconducting β-Sn...
June 27, 2023: ACS Nano
https://read.qxmd.com/read/37310207/three-dimensional-imaging-of-vascular-development-in-the-mouse-epididymis
#27
JOURNAL ARTICLE
Christelle Damon-Soubeyrand, Antonino Bongiovanni, Areski Chorfa, Chantal Goubely, Nelly Pirot, Luc Pardanaud, Laurence Piboin-Fragner, Caroline Vachias, Stephanie Bravard, Rachel Guiton, Jean-Leon Thomas, Fabrice Saez, Ayhan Kocer, Meryem Tardivel, Joël R Drevet, Joelle Henry-Berger
Long considered an accessory tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fertility. In addition to its secretory role in ensuring functional maturation and survival of spermatozoa, the epididymis has a complex immune function. Indeed, it must manage both peripheral tolerance to sperm antigens foreign to the immune system and the protection of spermatozoa as well as the organ itself against pathogens ascending the epididymal tubule. Although our knowledge of the immunobiology of this organ is beginning to accumulate at the molecular and cellular levels, the organization of blood and lymphatic networks of this tissue, important players in the immune response, remains largely unknown...
June 13, 2023: ELife
https://read.qxmd.com/read/37295402/temperature-dependent-rna-editing-in-octopus-extensively-recodes-the-neural-proteome
#28
JOURNAL ARTICLE
Matthew A Birk, Noa Liscovitch-Brauer, Matthew J Dominguez, Sean McNeme, Yang Yue, J Damon Hoff, Itamar Twersky, Kristen J Verhey, R Bryan Sutton, Eli Eisenberg, Joshua J C Rosenthal
In poikilotherms, temperature changes challenge the integration of physiological function. Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods, these problems are substantial. RNA editing by adenosine deamination is a well-positioned mechanism for environmental acclimation. We report that the neural proteome of Octopus bimaculoides undergoes massive reconfigurations via RNA editing following a temperature challenge. Over 13,000 codons are affected, and many alter proteins that are vital for neural processes...
June 8, 2023: Cell
https://read.qxmd.com/read/37255534/comparing-synaptic-proteomes-across-five-mouse-models-for-autism-reveals-converging-molecular-similarities-including-deficits-in-oxidative-phosphorylation-and-rho-gtpase-signaling
#29
JOURNAL ARTICLE
Abigail U Carbonell, Carmen Freire-Cobo, Ilana V Deyneko, Saunil Dobariya, Hediye Erdjument-Bromage, Amy E Clipperton-Allen, Damon T Page, Thomas A Neubert, Bryen A Jordan
Specific and effective treatments for autism spectrum disorder (ASD) are lacking due to a poor understanding of disease mechanisms. Here we test the idea that similarities between diverse ASD mouse models are caused by deficits in common molecular pathways at neuronal synapses. To do this, we leverage the availability of multiple genetic models of ASD that exhibit shared synaptic and behavioral deficits and use quantitative mass spectrometry with isobaric tandem mass tagging (TMT) to compare their hippocampal synaptic proteomes...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37222169/increasing-equity-of-physical-activity-promotion-for-optimal-cardiovascular-health-in-adults-a-scientific-statement-from-the-american-heart-association
#30
REVIEW
Gerald J Jerome, William R Boyer, Eduardo E Bustamante, Jacob Kariuki, Francisco Lopez-Jimenez, Amanda E Paluch, Damon L Swift, Kashica J Webber-Ritchey, Bethany Barone Gibbs
Fewer than 1 in 4 adults achieves the recommended amount of physical activity, with lower activity levels reported among some groups. Addressing low levels of physical activity among underresourced groups provides a modifiable target with the potential to improve equity in cardiovascular health. This article (1) examines physical activity levels across strata of cardiovascular disease risk factors, individual level characteristics, and environmental factors; (2) reviews strategies for increasing physical activity in groups who are underresourced or at risk for poor cardiovascular health; and (3) provides practical suggestions for physical activity promotion to increase equity of risk reduction and to improve cardiovascular health...
June 20, 2023: Circulation
https://read.qxmd.com/read/37220319/bad-to-the-bone-emerging-approaches-to-aggressive-bone-sarcomas
#31
JOURNAL ARTICLE
Georgina E Wood, Laurie A Graves, Elyssa M Rubin, Damon R Reed, Richard F Riedel, Sandra J Strauss
Bone sarcomas are rare heterogeneous tumors that affect patients of all ages including children, adolescent young adults, and older adults. They include many aggressive subtypes and patient groups with poor outcomes, poor access to clinical trials, and lack of defined standard therapeutic strategies. Conventional chondrosarcoma remains a surgical disease, with no defined role for cytotoxic therapy and no approved targeted systemic therapies. Here, we discuss promising novel targets and strategies undergoing evaluation in clinical trials...
May 2023: American Society of Clinical Oncology Educational Book
https://read.qxmd.com/read/37191698/young-women-and-elderly-men-at-risk-of-severe-faecal-incontinence-results-of-a-french-nationwide-database-analysis-faecal-incontinence-in-france
#32
JOURNAL ARTICLE
M Levaillant, A Venara, H Damon, L Siproudhis, C Brochard, J F Hamel
PURPOSE: The incidence of severe faecal incontinence (FI) in young people is likely underestimated. The objective of this study is to assess the incidence of FI by using the French national insurance information system (SNDS). METHODS: The SNDS was used, including 2 health insurance claims databases. The study included 49,097,454 French people who were ≥ 20 years old in 2019. The main outcome measure was the occurrence of FI. RESULTS: In 2019, 123,630 patients out of the entire French population (n = 49 097 454) (0...
May 16, 2023: International Journal of Colorectal Disease
https://read.qxmd.com/read/37128587/image-data-and-computational-grids-for-computing-brain-shift-and-solving-the-electrocorticography-forward-problem
#33
JOURNAL ARTICLE
Benjamin F Zwick, Saima Safdar, George C Bourantas, Grand R Joldes, Damon E Hyde, Simon K Warfield, Adam Wittek, Karol Miller
This article describes the dataset applied in the research reported in NeuroImage article "Patient-specific solution of the electrocorticography forward problem in deforming brain" [1] that is available for download from the Zenodo data repository (https://zenodo.org/record/7687631) [2]. Preoperative structural and diffusion-weighted magnetic resonance (MR) and postoperative computed tomography (CT) images of a 12-year-old female epilepsy patient under evaluation for surgical intervention were obtained retrospectively from Boston Children's Hospital...
June 2023: Data in Brief
https://read.qxmd.com/read/37127375/the-complexity-of-trauma-for-lgbtq-people-considerations-for-acute-and-critical-care
#34
REVIEW
Damon B Cottrell, Lori Aaron-Brija, Emily Berkowitz, Jeffrey Williams
Trauma care is complex. Acute and critical care clinicians perceive trauma as a skilled response to critical injury or accident that occurs to patients, but trauma exists on many levels. One of those is a grim reality for patients who are lesbian, gay, bisexual, transgender, queer or questioning, and from other sexual and gender minorities (LGBTQ+). A lifetime of trauma through stigma, discrimination, and victimization is too often present. Owing to distrust of the health care system and clinicians, LGBTQ+ experience health and health care disparities...
June 2023: Critical Care Nursing Clinics of North America
https://read.qxmd.com/read/37077218/development-of-polarization-sensitive-optical-coherence-tomography-imaging-platform-and-metrics-to-quantify-electrostimulation-induced-peripheral-nerve-injury-in-vivo-in-a-small-animal-model
#35
JOURNAL ARTICLE
Guillermo L Monroy, Mohsen Erfanzadeh, Michael Tao, Damon T DePaoli, Ilyas Saytashev, Stephanie A Nam, Harmain Rafi, Kasey C Kwong, Katherine Shea, Benjamin J Vakoc, Srikanth Vasudevan, Daniel X Hammer
SIGNIFICANCE: Neuromodulation devices are rapidly evolving for the treatment of neurological diseases and conditions. Injury from implantation or long-term use without obvious functional losses is often only detectable through terminal histology. New technologies are needed that assess the peripheral nervous system (PNS) under normal and diseased or injured conditions. AIM: We aim to demonstrate an imaging and stimulation platform that can elucidate the biological mechanisms and impacts of neurostimulation in the PNS and apply it to the sciatic nerve to extract imaging metrics indicating electrical overstimulation...
April 2023: Neurophotonics
https://read.qxmd.com/read/37042104/experiences-of-black-adults-evaluated-in-a-locked-psychiatric-emergency-unit-a-qualitative-study
#36
JOURNAL ARTICLE
Colin M Smith, Lori-Ann Daley, Chris Lea, Keith Daniel, Damon S Tweedy, Nathan M Thielman, B Lynette Staplefoote-Boynton, Elizabeth Aimone, Jane P Gagliardi
OBJECTIVE: Evidence shows that Black individuals have higher rates of coercive emergency psychiatric interventions than other racialized groups, yet no studies have elevated the voices of Black patients undergoing emergency psychiatric evaluation. This qualitative study sought to explore the experiences of Black individuals who had been evaluated in a locked psychiatric emergency unit (PEU). METHODS: Electronic health records were used to identify and recruit adult patients (ages ≥18 years) who self-identified as Black and who had undergone evaluation in a locked PEU at a large academic medical center...
April 12, 2023: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/37039398/preliminary-evidence-of-transcutaneous-vagus-nerve-stimulation-effects-on-sleep-in-veterans-with-post-traumatic-stress-disorder
#37
JOURNAL ARTICLE
Sarah A Bottari, Damon G Lamb, Eric C Porges, Aidan J Murphy, Amy B Tran, Raffaele Ferri, Michael S Jaffee, Maria I Davila, Simon Hartmann, Mathias Baumert, John B Williamson
Sleep problems are common among veterans with post-traumatic stress disorder and closely associated with hyperarousal symptoms. Transcutaneous vagus nerve stimulation (tVNS) may have potential to improve sleep quality in veterans with PTSD through effects on brain systems relevant to hyperarousal and sleep-wake regulation. The current pilot study examines the effect of 1 h of tVNS administered at "lights out" on sleep architecture, microstructure, and autonomic activity. Thirteen veterans with PTSD completed two nights of laboratory-based polysomnography during which they received 1 h of either active tVNS (tragus) or sham stimulation (earlobe) at "lights out" with randomised order...
April 11, 2023: Journal of Sleep Research
https://read.qxmd.com/read/37028905/neuroprognostication-in-the-post-cardiac-arrest-patient-a-canadian-cardiovascular-society-position-statement
#38
Christopher B Fordyce, Andreas H Kramer, Craig Ainsworth, Jim Christenson, Gary Hunter, Julie Kromm, Carmen Lopez Soto, Damon C Scales, Mypinder Sekhon, Sean van Diepen, Laura Dragoi, Colin Josephson, Jim Kutsogiannis, Michel R Le May, Christopher B Overgaard, Martin Savard, Gregory Schnell, Graham C Wong, Emilie Belley-Côté, Tadeu A Fantaneanu, Christopher B Granger, Adriana Luk, Rebecca Mathew, Victoria McCredie, Laurel Murphy, Jeanne Teitelbaum
Cardiac arrest (CA) is associated with a low rate of survival with favourable neurologic recovery. The most common mechanism of death after successful resuscitation from CA is withdrawal of life-sustaining measures on the basis of perceived poor neurologic prognosis due to underlying hypoxic-ischemic brain injury. Neuroprognostication is an important component of the care pathway for CA patients admitted to hospital but is complex, challenging, and often guided by limited evidence. Using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to evaluate the evidence underlying factors or diagnostic modalities available to determine prognosis, recommendations were generated in the following domains: (1) circumstances immediately after CA; (2) focused neurologic exam; (3) myoclonus and seizures; (4) serum biomarkers; (5) neuroimaging; (6) neurophysiologic testing; and (7) multimodal neuroprognostication...
April 2023: Canadian Journal of Cardiology
https://read.qxmd.com/read/37014451/absence-of-the-torcular-review-of-venous-sinus-anatomy-and-the-simplified-dural-sinus-classification
#39
JOURNAL ARTICLE
Fidel Valero-Moreno, Michael W Pullen, Guiselle Navarro-Martínez, Henry Ruiz-Garcia, Ricardo A Domingo, Jaime L Martínez, Paola Suarez-Meade, Aaron Damon, Alfredo Quiñones-Hinojosa, Sukhwinder Js Sandhu, Rabih G Tawk, W Christopher Fox
BACKGROUND: Classically, the torcular Herophili is described as the symmetric junction between the superior sagittal sinus (SSS), transverse sinuses (TSs), and straight sinus (SS). However, finding this pattern in practice is not standard. Anatomical variations are common, and different drainage patterns should be expected. Existing literature proposes highly detailed descriptions and classifications of this region. Still, a simplified and practical categorization is not available. METHODS: We present an anatomical finding of the torcular Herophili discovered on a cadaveric dissection...
July 2023: Acta Neurochirurgica
https://read.qxmd.com/read/36904624/integrated-land-suitability-assessment-for-depots-siting-in-a-sustainable-biomass-supply-chain
#40
JOURNAL ARTICLE
Ange-Lionel Toba, Rajiv Paudel, Yingqian Lin, Rohit V Mendadhala, Damon S Hartley
A sustainable biomass supply chain would require not only an effective and fluid transportation system with a reduced carbon footprint and costs, but also good soil characteristics ensuring durable biomass feedstock presence. Unlike existing approaches that fail to account for ecological factors, this work integrates ecological as well as economic factors for developing sustainable supply chain development. For feedstock to be sustainably supplied, it necessitates adequate environmental conditions, which need to be captured in supply chain analysis...
February 22, 2023: Sensors
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