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https://www.readbyqxmd.com/read/28074565/sustaining-screening-brief-intervention-and-referral-to-treatment-sbirt-services-in-health-care-settings
#1
Manu Singh, Amanda Gmyrek, Amy Hernandez, Donna Damon, Susan Hayashi
AIMS: To assess the sustainability of Screening, Brief Intervention and Referral to Treatment (SBIRT) services after cessation of initial start-up funding. DESIGN: Descriptive study with quantitative and qualitative data collected from 34 staff participants from six grantees (comprising 103 sites) funded previously through a large, federally supported SBIRT program. SETTING: Primary care out-patient clinics and hospitals in the United States...
February 2017: Addiction
https://www.readbyqxmd.com/read/28068420/graphics-processing-unit-accelerated-code-for-computing-second-order-wiener-kernels-and-spike-triggered-covariance
#2
Omer Mano, Damon A Clark
Sensory neuroscience seeks to understand and predict how sensory neurons respond to stimuli. Nonlinear components of neural responses are frequently characterized by the second-order Wiener kernel and the closely-related spike-triggered covariance (STC). Recent advances in data acquisition have made it increasingly common and computationally intensive to compute second-order Wiener kernels/STC matrices. In order to speed up this sort of analysis, we developed a graphics processing unit (GPU)-accelerated module that computes the second-order Wiener kernel of a system's response to a stimulus...
2017: PloS One
https://www.readbyqxmd.com/read/28060254/quantitative-magnetic-resonance-imaging-of-skeletal-muscle-disease
#3
Bruce M Damon, Ke Li, Richard D Dortch, E Brian Welch, Jane H Park, Amanda K W Buck, Theodore F Towse, Mark D Does, Daniel F Gochberg, Nathan D Bryant
Quantitative magnetic resonance imaging (qMRI) describes the development and use of MRI to quantify physical, chemical, and/or biological properties of living systems. Neuromuscular diseases often exhibit a temporally varying, spatially heterogeneous, and multi-faceted pathology. The goal of this protocol is to characterize this pathology using qMRI methods. The MRI acquisition protocol begins with localizer images (used to locate the position of the body and tissue of interest within the MRI system), quality control measurements of relevant magnetic field distributions, and structural imaging for general anatomical characterization...
December 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28048792/mo-de-206-01-cellular-metabolism-of-fdg
#4
G Pratx
: In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048135/mo-de-206-02-cellular-metabolism-of-fdg
#5
S Cherry
: In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047484/mo-de-206-03-quantifying-metabolism-with-hyperpolarized-mr
#6
J Bankson
: In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046736/mo-de-206-00-joint-aapm-wmis-symposium-metabolic-imaging-of-cancer
#7
John Hazle, Zaver Bhujwalla
: In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28024890/assessment-of-cell-viability-and-permeation-enhancement-in-presence-of-lipid-based-self-emulsifying-drug-delivery-systems-using-caco-2-cell-model-polysorbate-80-as-the-surfactant
#8
Pengli Bu, Yue Ji, Silpa Narayanan, Damon Dalrymple, Xingguo Cheng, Abu T M Serajuddin
PURPOSE: Lipid-based self-emulsifying drug delivery systems (SEDDS) are commonly used for solubilizing and enhancing oral bioavailability of poorly water-soluble drugs. However, their effects on viability of intestine epithelial cells and influence on membrane permeation are poorly understood. The present study was undertaken for safety assessment of lipid-based formulations containing medium-chain fatty acid esters as lipids and polysorbate 80 as the surfactant using the Caco-2 in vitro model...
December 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27890512/safety-and-efficacy-of-valve-repositioning-during-transcatheter-aortic-valve-replacement-with-the-lotus-valve-system
#9
Hashrul N Z Rashid, Robert Gooley, Liam McCormick, Sarah Zaman, Satish Ramkumar, Damon Jackson, Ameera Amiruddin, Arthur Nasis, James Cameron, Ian T Meredith
OBJECTIVE: To determine the safety and efficacy of valve repositioning following transcatheter aortic valve replacement (TAVR) with the Lotus Valve System (Boston Scientific, Marlborough, MA, USA). INTRODUCTION: TAVR is a well-established treatment for severe aortic stenosis. The Lotus Valve System is fully repositionable and retrievable. Valve repositioning has the potential to minimize TAVR-related complications caused by valve malposition; however, the effect on adverse event rates such as stroke is unknown...
November 24, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27863809/efficacy-and-safety-of-tau-aggregation-inhibitor-therapy-in-patients-with-mild-or-moderate-alzheimer-s-disease-a-randomised-controlled-double-blind-parallel-arm-phase-3-trial
#10
Serge Gauthier, Howard H Feldman, Lon S Schneider, Gordon K Wilcock, Giovanni B Frisoni, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Damon J Wischik, Bjoern O Schelter, Charles S Davis, Roger T Staff, Luc Bracoud, Kohkan Shamsi, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mouse models. Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease. We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease...
December 10, 2016: Lancet
https://www.readbyqxmd.com/read/27862860/incidence-and-predictors-of-permanent-pacemaker-implantation-following-treatment-with-the-repositionable-lotus%C3%A2-transcatheter-aortic-valve
#11
Sarah Zaman, Liam McCormick, Robert Gooley, Hashrul Rashid, Satish Ramkumar, Damon Jackson, Samuel Hui, Ian T Meredith
OBJECTIVES: To determine the incidence and predictors of permanent pacemaker (PPM) requirement following transcatheter aortic valve replacement (TAVR) with the mechanically expanded Lotus(TM) Valve System (Boston Scientific). BACKGROUND: Pacemaker implantation is the most common complication following TAVR. Predictors of pacing following TAVR with the Lotus valve have not been systematically assessed. METHODS: Consecutive patients with severe aortic stenosis who underwent Lotus valve implantation were prospectively recruited at a single-centre...
November 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27780048/parallel-computations-in-insect-and-mammalian-visual-motion-processing
#12
REVIEW
Damon A Clark, Jonathan B Demb
Sensory systems use receptors to extract information from the environment and neural circuits to perform subsequent computations. These computations may be described as algorithms composed of sequential mathematical operations. Comparing these operations across taxa reveals how different neural circuits have evolved to solve the same problem, even when using different mechanisms to implement the underlying math. In this review, we compare how insect and mammalian neural circuits have solved the problem of motion estimation, focusing on the fruit fly Drosophila and the mouse retina...
October 24, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27767044/direct-analysis-and-quantification-of-metaldehyde-in-water-using-reactive-paper-spray-mass-spectrometry
#13
Simon Maher, Fred P M Jjunju, Deidre E Damon, Hannah Gorton, Yosef S Maher, Safaraz U Syed, Ron M A Heeren, Iain S Young, Stephen Taylor, Abraham K Badu-Tawiah
Metaldehyde is extensively used worldwide as a contact and systemic molluscicide for controlling slugs and snails in a wide range of agricultural and horticultural crops. Contamination of surface waters due to run-off, coupled with its moderate solubility in water, has led to increased concentration of the pesticide in the environment. In this study, for the first time, rapid analysis (<~1 minute) of metaldehyde residues in water is demonstrated using paper spray mass spectrometry (PS-MS). The observed precursor molecular ions of metaldehyde were confirmed from tandem mass spectrometry (MS/MS) experiments by studying the fragmentation patterns produced via collision-induced dissociation...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659556/brief-isoflurane-anaesthesia-affects-differential-gene-expression-gene-ontology-and-gene-networks-in-rat-brain
#14
Damon A Lowes, Helen F Galley, Alessandro P S Moura, Nigel R Webster
Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential expression profiles with and without anaesthesia. We hypothesised that network analysis, in addition to the traditional differential gene expression and ontology analysis, would enable identification of the effects of anaesthesia on interactions between genes. Rats (n=10 per group) were randomised to anaesthesia with isoflurane in oxygen or oxygen only for 15min, and 6h later brains were removed...
September 19, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27658654/the-impact-of-hospital-experience-with-out-of-hospital-cardiac-arrest-patients-on-post-cardiac-arrest-care
#15
Heather Worthington, Will Pickett, Laurie J Morrison, Damon C Scales, Chun Zhan, Steve Lin, Paul Dorian, Katie N Dainty, Niall D Ferguson, Steven C Brooks
OBJECTIVE: Patient volume as a surrogate for institutional experience has been associated with quality of care indicators for a variety of illnesses. We evaluated the association between hospital experience with comatose out-of-hospital cardiac arrest (OHCA) patients and important care processes. METHODS: This was a population-based, retrospective cohort study using data from 37 hospitals in Southern Ontario from 2007 to 2013. We included adults with atraumatic OHCA who were comatose on emergency department arrival and survived at least 6h...
January 2017: Resuscitation
https://www.readbyqxmd.com/read/27621408/picasso-iii-a-phase-iii-placebo-controlled-study-of-doxorubicin-with-or-without-palifosfamide-in-patients-with-metastatic-soft-tissue-sarcoma
#16
Christopher W Ryan, Ofer Merimsky, Mark Agulnik, Jean-Yves Blay, Scott M Schuetze, Brian A Van Tine, Robin L Jones, Anthony D Elias, Edwin Choy, Thierry Alcindor, Vicki L Keedy, Damon R Reed, Robert N Taub, Antoine Italiano, Xavier Garcia Del Muro, Ian R Judson, Jill Y Buck, Francois Lebel, Jonathan J Lewis, Robert G Maki, Patrick Schöffski
PURPOSE: Palifosfamide is the active metabolite of ifosfamide and does not require prodrug activation, thereby avoiding the generation of toxic metabolites. The PICASSO III trial compared doxorubicin plus palifosfamide with doxorubicin plus placebo in patients who had received no prior systemic therapy for metastatic soft tissue sarcoma. PATIENTS AND METHODS: Patients were randomly assigned 1:1 to receive doxorubicin 75 mg/m(2) intravenously day 1 plus palifosfamide 150 mg/m(2)/d intravenously days 1 to 3 or doxorubicin plus placebo once every 21 days for up to six cycles...
September 12, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27586260/direct-observation-of-interfacial-dzyaloshinskii-moriya-interaction-from-asymmetric-spin-wave-propagation-in-w-cofeb-sio2-heterostructures-down-to-sub-nanometer-cofeb-thickness
#17
Avinash Kumar Chaurasiya, Chandrima Banerjee, Santanu Pan, Sourav Sahoo, Samiran Choudhury, Jaivardhan Sinha, Anjan Barman
Interfacial Dzyaloshinskii-Moriya interaction (IDMI) is important for its roles in stabilizing the skyrmionic lattice as well as soliton-like domain wall motion leading towards new generation spintronic devices. However, achievement and detection of IDMI is often hindered by various spurious effects. Here, we demonstrate the occurrence of IDMI originating primarily from W/CoFeB interface in technologically important W/CoFeB/SiO2 heterostructures using Brillouin light scattering technique. Due to the presence of IDMI, we observe asymmetry in the peak frequency and linewidth of the spin-wave spectra in the Damon-Eshbach (DE) geometry at finite k wave-vectors...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27568861/nicotinic-receptor-subtypes-differentially-modulate-glutamate-release-in-the-dorsal-medial-striatum
#18
William M Howe, Damon A Young, George Bekheet, Rouba Kozak
The dorsal medial striatum is a crucial part of the neural network that subserves dynamic, goal-directed behaviors. Functional output of this nucleus is shaped, in part, by the influence of glutamatergic inputs. Striatal cholinergic systems have the capacity to modulate these excitatory inputs through presynaptic nicotinic acetylcholine receptors (nAChRs); however, the individual contribution of the two major nicotinic receptor subtypes, α4β2 and α7, to such modulation is not well characterized. In the present experiments, glutamate biosensors were used to monitor nAChR-dependent glutamate release with high temporal precision in the dorsal medial striatum of rats...
August 26, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27510321/mesenchymal-stem-cells-enhance-nerve-regeneration-in-a-rat-sciatic-nerve-repair-and-hindlimb-transplant-model
#19
Damon S Cooney, Eric G Wimmers, Zuhaib Ibrahim, Johanna Grahammer, Joani M Christensen, Gabriel A Brat, Lehao W Wu, Karim A Sarhane, Joseph Lopez, Christoph Wallner, Georg J Furtmüller, Nance Yuan, John Pang, Kakali Sarkar, W P Andrew Lee, Gerald Brandacher
This study investigates the efficacy of local and intravenous mesenchymal stem cell (MSC) administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. Bone marrow-derived MSCs were harvested and purified from Brown-Norway (BN) rats. Sciatic nerve transections and repairs were performed in three groups of Lewis (LEW) rats: negative controls (n = 4), local MSCs (epineural) injection (n = 4), and systemic MSCs (intravenous) injection (n = 4)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27479957/dynamic-electrical-source-imaging-desi-of-seizures-and-interictal-epileptic-discharges-without-ensemble-averaging
#20
Burak Erem, Damon E Hyde, Jurriaan M Peters, Frank H Duffy, Simon K Warfield
We propose an algorithm for electrical source imaging of epileptic discharges that takes a data-driven approach to regularizing the dynamics of solutions. The method is based on linear system identification on short time segments, combined with a classical inverse solution approach. Whereas ensemble averaging of segments or epochs discards inter-segment variations by averaging across them, our approach explicitly models them. Indeed, it may even be possible to avoid the need for the time-consuming process of marking epochs containing discharges altogether...
January 2017: IEEE Transactions on Medical Imaging
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