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https://www.readbyqxmd.com/read/29061621/detection-and-management-of-familial-hypercholesterolaemia-in-primary-care-in-australia-protocol-for-a-pragmatic-cluster-intervention-study-with-pre-post-intervention-comparisons
#1
Diane E Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Ian Li, Max Bulsara, Gerald F Watts
INTRODUCTION: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. METHODS AND ANALYSIS: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29060394/automatic-visual-impairment-detection-system-for-age-related-eye-diseases-through-gaze-analysis
#2
Ai Ping Yow, Damon Wong, Huiying Liu, Hongyuan Zhu, Ivy Jing-Wen Ong, Augustinus Laude, Tock Han Lim
Visual impairment associated with Age-related Macular Degeneration (AMD) often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods for assessing visual performance such as Amsler grid and Microperimetry are typically manual and have limitations as an indicator of visual field. In this paper, we present an automated system for detecting visual impairment through gaze tracking (AVIGA). Two types of assessments namely, Impulse Stimuli Response (ISR) test and Pursuit Stimuli Response (PSR) test were implemented in AVIGA system...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057677/effect-of-different-polysorbates-on-development-of-self-microemulsifying-drug-delivery-systems-using-medium-chain-lipids
#3
Ankita Shah, Prajwal Thool, Komal Sorathiya, Hetal Prajapati, Damon Dalrymple, Abu T M Serajuddin
The primary objective of this study was to develop lipid-based self-microemulsifying drug delivery systems (SMEDDS) without using any organic cosolvents that would spontaneously form microemulsions upon dilution with water. Cosolvents were avoided to prevent possible precipitation of drug upon dilution and other stability issues. Different polysorbates, namely, Tween 20, Tween 40, Tween 60, and Tween 80, were used as surfactants, and Captex 355 EP/NF (glycerol tricaprylate/caprate) or its 1:1 mixture with Capmul MCM NF (glycerol monocaprylocaprate) were used as lipids...
October 23, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29036309/chiral-analysis-of-methamphetamine-in-oral-fluid-samples-a-method-to-distinguish-licit-from-illicit-drug-use
#4
Damon Borg, Elizabeth Kolb, Cindy Lantigua, Richard Stripp
Methamphetamine (MAMP) is a popular illicit drug abused for its central nervous system stimulating effects. MAMP is also used therapeutically in the treatment of overeating disorders, narcolepsy, attention deficit disorder, in over-the-counter (OTC) products to ease nasal congestion. MAMP exists in two enantiomeric forms, dextrorotary (d-MAMP) or levorotary (l-MAMP). The compounds are similar in chemical structure, simply differing in the orientation of functional groups around the asymmetric carbon. In part because of the availability of l-MAMP in OTC nasal inhalers, forensic guidelines require a sample to contain greater than 20% d-MAMP to consider illicit drug use when interpreting results...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29033177/arsenic-phosphorus-interactions-in-the-soil-plant-microbe-system-dynamics-of-uptake-suppression-and-toxicity-to-plants
#5
Hossain M Anawar, Zed Rengel, Paul Damon, Mark Tibbett
High arsenic (As) concentrations in the soil, water and plant systems can pose a direct health risk to humans and ecosystems. Phosphate (Pi) ions strongly influence As availability in soil, its uptake and toxicity to plants. Better understanding of As(V)-Pi interactions in soils and plants will facilitate a potential remediation strategy for As contaminated soils, reducing As uptake by crop plants and toxicity to human populations via manipulation of soil Pi content. However, the As(V)-Pi interactions in soil-plant systems are complex, leading to contradictory findings among different studies...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28988646/pembrolizumab-in-advanced-soft-tissue-sarcoma-and-bone-sarcoma-sarc028-a-multicentre-two-cohort-single-arm-open-label-phase-2-trial
#6
Hussein A Tawbi, Melissa Burgess, Vanessa Bolejack, Brian A Van Tine, Scott M Schuetze, James Hu, Sandra D'Angelo, Steven Attia, Richard F Riedel, Dennis A Priebat, Sujana Movva, Lara E Davis, Scott H Okuno, Damon R Reed, John Crowley, Lisa H Butterfield, Ruth Salazar, Jaime Rodriguez-Canales, Alexander J Lazar, Ignacio I Wistuba, Laurence H Baker, Robert G Maki, Denise Reinke, Shreyaskumar Patel
BACKGROUND: Patients with advanced sarcomas have a poor prognosis and few treatment options that improve overall survival. Chemotherapy and targeted therapies offer short-lived disease control. We assessed pembrolizumab, an anti-PD-1 antibody, for safety and activity in patients with advanced soft-tissue sarcoma or bone sarcoma. METHODS: In this two-cohort, single-arm, open-label, phase 2 study, we enrolled patients with soft-tissue sarcoma or bone sarcoma from 12 academic centres in the USA that were members of the Sarcoma Alliance for Research through Collaboration (SARC)...
October 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28980702/detection-of-generalized-tonic-clonic-seizures-using-surface-electromyographic-monitoring
#7
MULTICENTER STUDY
Jonathan J Halford, Michael R Sperling, Dileep R Nair, Dennis J Dlugos, William O Tatum, Jay Harvey, Jacqueline A French, John R Pollard, Edward Faught, Katherine H Noe, Thomas R Henry, Gina M Jetter, Octavian V Lie, Lola C Morgan, Michael R Girouard, Damon P Cardenas, Luke E Whitmire, Jose E Cavazos
OBJECTIVE: A prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in the epilepsy monitoring unit (EMU) of an investigational wearable surface electromyographic (sEMG) monitoring system for the detection of generalized tonic-clonic seizures (GTCSs). METHODS: One hundred ninety-nine patients with a history of GTCSs who were admitted to the EMU in 11 level IV epilepsy centers for clinically indicated video-electroencephalographic monitoring also received sEMG monitoring with a wearable device that was worn on the arm over the biceps muscle...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/28973088/association-between-immigrant-status-and-end-of-life-care-in-ontario-canada
#8
Christopher J Yarnell, Longdi Fu, Doug Manuel, Peter Tanuseputro, Therese Stukel, Ruxandra Pinto, Damon C Scales, Andreas Laupacis, Robert A Fowler
Importance: People who immigrate face unique health literacy, communication, and system navigation challenges, and they may have diverse preferences that influence end-of-life care. Objective: To examine end-of-life care provided to immigrants to Canada in the last 6 months of their life. Design, Setting, and Participants: This population-based cohort study (April 1, 2004, to March 31, 2015) included 967 013 decedents in Ontario, Canada, using validated linkages between health and immigration databases to identify immigrant (since 1985) and long-standing resident cohorts...
October 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28765720/a-global-map-of-saltmarshes
#9
Chris J Mcowen, Lauren V Weatherdon, Jan-Willem Van Bochove, Emma Sullivan, Simon Blyth, Christoph Zockler, Damon Stanwell-Smith, Naomi Kingston, Corinne S Martin, Mark Spalding, Steven Fletcher
BACKGROUND: Saltmarshes are extremely valuable but often overlooked ecosystems, contributing to livelihoods locally and globally through the associated ecosystem services they provide, including fish production, carbon storage and coastal protection. Despite their importance, knowledge of the current spatial distribution (occurrence and extent) of saltmarshes is incomplete. In light of increasing anthropogenic and environmental pressures on coastal ecosystems, global data on the occurrence and extent of saltmarshes are needed to draw attention to these critical ecosystems and to the benefits they generate for people...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/28742420/orthodontics-with-customized-versus-noncustomized-appliances-a-randomized-controlled-clinical-trial
#10
E W Penning, R H J Peerlings, J D M Govers, R J Rischen, K Zinad, E M Bronkhorst, K H Breuning, A M Kuijpers-Jagtman
This randomized controlled trial aimed to evaluate the duration and outcome quality of orthodontic treatment with a customized fixed appliance system versus a noncustomized system. Patients ( n = 180) were randomized and received orthodontic treatment with the Insignia customized orthodontic system or the Damon Q noncustomized orthodontic system. The allocation sequence was concealed using identical, sequentially numbered, opaque, sealed envelopes. Patients with nonextraction treatment plans were treated by 2 equally experienced orthodontists...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732167/quantum-transport-and-sub-band-structure-of-modulation-doped-gaas-alas-core-superlattice-nanowires
#11
Dominik M Irber, Jakob Seidl, Damon J Carrad, Jonathan Becker, Nari Jeon, Bernhard Loitsch, Julia Winnerl, Sonja Matich, Markus Döblinger, Yang Tang, Stefanie Morkötter, Gerhard Abstreiter, Jonathan J Finley, Matthew Grayson, Lincoln J Lauhon, Gregor Koblmüller
Modulation-doped III-V semiconductor nanowire (NW) heterostructures have recently emerged as promising candidates to host high-mobility electron channels for future high-frequency, low-energy transistor technologies. The one-dimensional geometry of NWs also makes them attractive for studying quantum confinement effects. Here, we report correlated investigations into the discrete electronic sub-band structure of confined electrons in the channel of Si δ-doped GaAs-GaAs/AlAs core-superlattice NW heterostructures and the associated signatures in low-temperature transport...
July 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28720450/detection-of-cervical-precancerous-lesions-with-aptima-hpv-assays-using-surepath-preservative-fluid-specimens
#12
Max Chernesky, Dan Jang, Nick Escott, Jodi Gilchrist, Jenny Li, Laurie Elit, Alice Lytwyn, Marek Smieja, Sam Ratnam, Manuel Arias, Damon Getman, Barbara Weinbaum, Brett Kirkconnell, Janel Dockter
SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS) before testing in Aptima HPV (AHPV) and Aptima HPV 16, 18/45 (AHPV-GT) assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91) was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28696746/coherent-plasmon-and-phonon-plasmon-resonances-in-carbon-nanotubes
#13
Abram L Falk, Kuan-Chang Chiu, Damon B Farmer, Qing Cao, Jerry Tersoff, Yi-Hsien Lee, Phaedon Avouris, Shu-Jen Han
Carbon nanotubes provide a rare access point into the plasmon physics of one-dimensional electronic systems. By assembling purified nanotubes into uniformly sized arrays, we show that they support coherent plasmon resonances, that these plasmons couple to nanotube and substrate phonons, and that the resulting phonon-plasmon resonances have quality factors as high as 10. Because nanotube plasmons intensely strengthen electromagnetic fields and light-matter interactions, they provide a compelling platform for surface-enhanced spectroscopy and tunable optical devices at deep-subwavelength scales...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28651927/doxorubicin-plus-evofosfamide-versus-doxorubicin-alone-in-locally-advanced-unresectable-or-metastatic-soft-tissue-sarcoma-th-cr-406-sarc021-an-international-multicentre-open-label-randomised-phase-3-trial
#14
RANDOMIZED CONTROLLED TRIAL
William D Tap, Zsuzsanna Papai, Brian A Van Tine, Steven Attia, Kristen N Ganjoo, Robin L Jones, Scott Schuetze, Damon Reed, Sant P Chawla, Richard F Riedel, Anders Krarup-Hansen, Maud Toulmonde, Isabelle Ray-Coquard, Peter Hohenberger, Giovanni Grignani, Lee D Cranmer, Scott Okuno, Mark Agulnik, William Read, Christopher W Ryan, Thierry Alcindor, Xavier F Garcia Del Muro, G Thomas Budd, Hussein Tawbi, Tillman Pearce, Stew Kroll, Denise K Reinke, Patrick Schöffski
BACKGROUND: Evofosfamide is a hypoxia-activated prodrug of bromo-isophosphoramide mustard. We aimed to assess the benefit of adding evofosfamide to doxorubicin as first-line therapy for advanced soft-tissue sarcomas. METHODS: We did this international, open-label, randomised, phase 3, multicentre trial (TH CR-406/SARC021) at 81 academic or community investigational sites in 13 countries. Eligible patients were aged 15 years or older with a diagnosis of an advanced unresectable or metastatic soft-tissue sarcoma, of intermediate or high grade, for which no standard curative therapy was available, an Eastern Cooperative Oncology Group performance status of 0-1, and measurable disease by Response Evaluation Criteria in Solid Tumors version 1...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28438227/characterization-of-carbon-monoxide-exposure-during-hurricane-sandy-and-subsequent-nor-easter
#15
Amy Schnall, Royal Law, Amy Heinzerling, Kanta Sircar, Scott Damon, Fuyuen Yip, Josh Schier, Tesfaye Bayleyegn, Amy Wolkin
OBJECTIVE: Carbon monoxide (CO) is an odorless, colorless gas produced by fossil fuel combustion. On October 29, 2012, Hurricane Sandy moved ashore near Atlantic City, New Jersey, causing widespread morbidity and mortality, $30 to $50 billion in economic damage, and 8.5 million households to be without power. The combination of power outages and unusually low temperatures led people to use alternate power sources, placing many at risk for CO exposure. METHODS: We examined Hurricane Sandy-related CO exposures from multiple perspectives to help identify risk factors and develop strategies to prevent future exposures...
April 25, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28390395/myoepithelial-carcinoma-with-rb1-mutation-remarkable-chemosensitivity-to-carcinoma-of-unknown-origin-therapy
#16
Timothy M Hoggard, Evita Henderson-Jackson, Marilyn M Bui, Jamie Caracciolo, Jamie K Teer, Sean Yoder, Odion Binitie, Ricardo J Gonzalez, Andrew S Brohl, Damon R Reed
BACKGROUND: Myoepithelial carcinoma of soft tissue is a rare, malignant neoplasm that is morphologically and immunophenotypically similar to its counterpart in salivary gland. It demonstrates myoepithelial differentiation, possessing both epithelial and myogenic characteristics. Thought to be chemotherapy insensitive, the optimal treatment regimen of this tumor has yet to be established and only a select few cases in the literature discuss treatment efficacy in detail. CASE PRESENTATION: Here we present a case of a young adult with metastatic myoepithelial carcinoma with an initial excellent response to systemic therapy utilizing carboplatin and paclitaxel with continued complete response after 3 years...
April 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28339591/comparison-of-the-force-levels-among-labial-and-lingual-self-ligating-and-conventional-brackets-in-simulated-misaligned-teeth
#17
Ahmad Alobeid, Tarek El-Bialy, Said Khawatmi, Cornelius Dirk, Andreas Jäger, Christoph Bourauel
Background/objective: The aim of this study was to evaluate force levels exerted by levelling arch wires with labial and lingual conventional and self-ligating brackets. Materials/methods: The tested orthodontic brackets were of the 0.022-in slot size for labial and 0.018-in for lingual brackets and were as follows: 1. Labial brackets: (i) conventional bracket (GAC-Twin, Dentsply), (ii) passive self-ligating (SL) brackets (Damon-Q®, ORMCO; Ortho classic H4™, Orthoclassic; FLI®SL, Rocky Mountain Orthodontics) and (iii) active SL brackets (GAC In-Ovation®C, DENTSPLY and SPEED™, Strite)...
August 1, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28323337/treatment-pathway-of-bone-sarcoma-in-children-adolescents-and-young-adults
#18
REVIEW
Damon R Reed, Masanori Hayashi, Lars Wagner, Odion Binitie, Diana A Steppan, Andrew S Brohl, Eric T Shinohara, Julia A Bridge, David M Loeb, Scott C Borinstein, Michael S Isakoff
When pediatric, adolescent, and young adult patients present with a bone sarcoma, treatment decisions, especially after relapse, are complex and require a multidisciplinary approach. This review presents scenarios commonly encountered in the therapy of bone sarcomas with the goal of objectively presenting a consensus, multidisciplinary management approach. Little variation was found in the authors' group with respect to local control or systemic therapy. Clinical trials were universally prioritized in all settings...
June 15, 2017: Cancer
https://www.readbyqxmd.com/read/28303773/improving-disaster-response-efforts-through-the-development-of-a-disaster-health-care-response-system
#19
Jonathan A Wilson, L Kendall McKenzie, W Terry McLeod, Damon A Darsey, Jim Craig
We review the development of a disaster health care response system in Mississippi aimed at improving disaster response efforts. Large-scale disasters generate many injured and ill patients, which causes a significant utilization of emergency health care services and often requires external support to meet clinical needs. Disaster health care services require a solid infrastructure of coordination and collaboration to be effective. Following Hurricane Katrina, the state of Mississippi implemented best practices from around the nation to establish a disaster health care response system...
March 17, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28269137/automated-in-vivo-3d-high-definition-optical-coherence-tomography-skin-analysis-system
#20
Ai Ping Yow, Jun Cheng, Annan Li, Ruchir Srivastava, Jiang Liu, Damon Wing Kee Wong, Hong Liang Tey
The in vivo assessment and visualization of skin structures can be performed through the use of high resolution optical coherence tomography imaging, also known as HD-OCT. However, the manual assessment of such images can be exhaustive and time consuming. In this paper, we present an analysis system to automatically identify and quantify the skin characteristics such as the topography of the surface of the skin and thickness of the epidermis in HD-OCT images. Comparison of this system with manual clinical measurements demonstrated its potential for automatic objective skin analysis and diseases diagnosis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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