keyword
https://read.qxmd.com/read/38492561/efficacy-and-safety-of-dupilumab-in-the-treatment-of-kimura-s-disease
#1
JOURNAL ARTICLE
Y L Liu, Y T Ran, Y F Zhang, X T Peng, Y M Xia, H L Yan
BACKGROUND: Kimura's disease (KD) is a rare chronic inflammatory condition characterized by nodules and lymphadenopathy in the head and neck region, exhibiting type II inflammation. Dupilumab is commonly used against type II inflammation. AIM: To evaluate the efficacy and safety of dupilumab in KD patients. DESIGN: The real-world study was conducted in a hospital in China. METHODS: Six male patients with a mean age of 24...
March 16, 2024: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/38483055/if-not-angioedema-what-is-it-diagnostic-approach-to-facial-edema
#2
REVIEW
Juan Pablo Velasco-Amador, Álvaro Prados-Carmona, Francisco José Navarro-Triviño
Facial edema is a relatively frequent clinical presentation encountered in patients seen in allergology and dermatology clinics. The differential diagnosis is broad, and sometimes the definitive diagnosis can be a challenge for the clinician. Facial angioedema itself encompasses different etiopathologies (histaminergic, bradykinergic, etc.) that must be distinguished from other causes of facial edema, such as allergic contact dermatitis, granulomatous conditions, inflammatory causes, infections, neoplasms or paraneoplastic syndromes, autoimmune diseases, among other entities hereby referred as miscellanea...
March 14, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
https://read.qxmd.com/read/38466972/oral-cannabidiol-for-seborrheic-dermatitis-in-patients-with-parkinson-disease-randomized-clinical-trial
#3
JOURNAL ARTICLE
Isaac Weber, Caterina Zagona-Prizio, Torunn E Sivesind, Madeline Adelman, Mindy D Szeto, Ying Liu, Stefan H Sillau, Jacquelyn Bainbridge, Jost Klawitter, Cristina Sempio, Cory A Dunnick, Maureen A Leehey, Robert P Dellavalle
BACKGROUND: Seborrheic dermatitis (SD) affects 18.6%-59% of persons with Parkinson disease (PD), and recent studies provide evidence that oral cannabidiol (CBD) therapy could reduce sebum production in addition to improving motor and psychiatric symptoms in PD. Therefore, oral CBD could be useful for improving symptoms of both commonly co-occurring conditions. OBJECTIVE: This study investigates whether oral CBD therapy is associated with a decrease in SD severity in PD...
March 11, 2024: JMIR dermatology
https://read.qxmd.com/read/38443954/eosinophilic-gastritis-and-gluten-sensitive-enteropathy-manifested-as-hypoproteinemia-and-treated-with-omalizumab-a-case-report
#4
JOURNAL ARTICLE
Zhirong Du, Zixi Wang, Weixun Zhou, Jia Yin, Yuxiang Zhi
BACKGROUND: Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this does occur, patients typically present with gastrointestinal symptoms. To our knowledge, hypoproteinemia has not been reported as the primary manifestation. Anti-IgE therapy, such as omalizumab, lowers eosinophil counts in the blood, lungs, and gut. Its efficiency in treating active EoG remain unknown. CASE PRESENTATION: We report a 33-month-old boy with a history of food allergy and atopic dermatitis who developed recurrent edema, hypoproteinemia, and eosinophilia at the age of 14 months...
March 5, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38439729/revive-the-dennie-morgan-fold-a-forgotten-sign-of-atopic-dermatitis-in-children
#5
JOURNAL ARTICLE
Rohan Shah, William C Lambert, Robert A Schwartz
In 1980, Hanifin and Rajka (1) proposed major and minor diagnostic criteria for atopic dermatitis (AD). Major associations included pruritus, dry skin, and history of atopy. One minor feature included Dennie-Morgan Folds (DMFs), which manifest as secondary creases in the skin underneath the inferior eyelid, usually found in infants (2). In an attempt to refine these criteria, a study evaluating 210 patients with an existing AD diagnosis observed DMF in 84% of AD cases. A pediatric study in Bijapur, India on 174 children under 16 years of age with AD identified DMF to be the most prevalent minor criterion...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38413004/idiopathic-aseptic-facial-granuloma-a-retrospective-study-of-43-cases
#6
JOURNAL ARTICLE
Lola Kuperman Wilder, Antonela Lamberti, Paula Boggio, María Eugenia Abad, Paula C Luna, Margarita Larralde
BACKGROUND: Idiopathic aseptic facial granuloma (IAFG) is an underrecognized pediatric skin disease, currently considered within the spectrum of rosacea. It usually manifests as a solitary, reddish, asymptomatic nodule on the cheek that resolves spontaneously. METHODS: Retrospective and descriptive observational study of 43 pediatric patients with a clinical diagnosis of IAFG, followed between 2004 and 2022, at two general hospitals in Argentina. RESULTS: IAFG predominated in girls (65%) and the average age of onset was about 6 years...
February 27, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38411257/sequential-therapy-with-topical-clobetasol-for-14%C3%A2-days-followed-by-hydroquinone-versus-hydroquinone-alone-in-facial-melasma-treatment-a-randomized-double-blind-controlled-clinical-trial
#7
JOURNAL ARTICLE
Rebecca P de Amorim, Mayla M C Barbosa, Daniel P Cassiano, Ana C C Esposito, Marina O Dias, Ana F T de Abreu, Ediléia Bagatin, Hélio A Miot
BACKGROUND: Clobetasol has demonstrated remarkable results in treating melasma within a short time frame; however, its use is limited because of the risk of local side effects. To date, there is no controlled trial on sequential clobetasol/hydroquinone for melasma. This study aimed to investigate the tolerability and efficacy of 0.05% clobetasol followed by 4% hydroquinone (CLOB-HQ) in comparison to the isolated use of 4% hydroquinone (HQ). METHODS: A double-blinded, randomized clinical trial involving 50 women with facial melasma was performed...
February 27, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38407422/residual-facial-erythema-in-atopic-dermatitis-patients-treated-with-dupilumab-stratified-by-machine-learning
#8
JOURNAL ARTICLE
Koichi Ashizaki, Tetsuo Ishikawa, Yuko Nomura
BACKGROUND: Persistent facial erythema represents a significant complication in atopic dermatitis (AD) patients undergoing treatment with dupilumab. Stratifying patients based on the erythema course is crucial for elucidating heterogeneous phenotypes and facilitating advanced drug efficacy predictions. OBJECTIVES: This study aimed to identify factors associated with facial erythema severity in dupilumab-treated AD patients and to establish a prediction model for drug response based on the identified factors...
February 26, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38375268/the-sentinel-rash-and-neurocutaneous-presentation-of-atrial-myxoma-case-report-and-literature-review
#9
Paul T Akins
INTRODUCTION: Presenting symptoms of atrial myxoma are classically viewed as a triad of cardiac, embolic, and constitutional symptoms. Dermatologic manifestations are viewed as constitutional symptoms and have not received much attention. METHODS: Illustrative case presentation and literature review. RESULTS: I admitted a 28 y woman transferred to the comprehensive stroke center with an ischemic stroke treated with intravenous thrombolysis...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38371662/a-real-world-study-of-dupilumab-in-patients-with-atopic-dermatitis-including-patients-with-malignancy-and-other-medical-comorbidities
#10
JOURNAL ARTICLE
Dea Metko, Maha Alkofide, Mohannad Abu-Hilal
BACKGROUND: Dupilumab is a monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (MtS-AD). Various clinical trials have established the effectiveness and safety of dupilumab for the treatment MtS-AD; however, the real-world experiences of patients treated with dupilumab with malignancy and other comorbidities are lacking. OBJECTIVE: To assess the real-life effectiveness and safety of dupilumab in the treatment of MtS-AD within Canadian adult patient population, including those with other significant comorbidities such as malignancy...
June 2024: JAAD international
https://read.qxmd.com/read/38362676/hepatic-and-renal-lesions-in-sheep-intoxicated-with-urochloa-hybrid-mulato-ii-in-argentina
#11
JOURNAL ARTICLE
Raúl E Marin, Eduardo J Gimeno, Franklin Riet-Correa, Francisco A Uzal
A flock of 48 sheep in Argentina grazing on a pasture of hybrid Urochloa (formerly Brachiaria ) Mulato II ( Urochloa ruziziensis  ×  Urochloa decumbens  ×  Urochloa brizantha ) developed facial dermatitis, severe jaundice, and weakness after brief physical activity. Blood biochemistry of 3 animals revealed azotemia, elevated aspartate aminotransferase activity, and increased direct, indirect, and total bilirubin concentrations. The urine was markedly turbid and contained large concentrations of bile pigments and protein...
February 16, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38346014/efficacy-of-immediate-postoperative-single-fractional-10%C3%A2-gy-radiotherapy-for-earlobe-keloids
#12
JOURNAL ARTICLE
Seung Hoon Han, Boram Ha, Choong Hyun Chang, Tae Hwan Park
BACKGROUND: The ear is a common site for keloid formation, typically due to ear piercing or trauma. Auricular keloids are always difficult to treat and pose a challenging situation. The purpose of this study is to present our experience treating earlobe keloids through complete surgical excision followed by immediate postoperative single fraction 10 Gy radiation therapy either on the same day or the next day. METHODS: The authors retrospectively evaluated 48 patients with 71 earlobe keloids treated with complete surgical excision followed by single-fractional 10 Gy radiotherapy within 24 hours from May 2021 to December 2022...
February 12, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38332535/ocular-surface-disease-in-moderate-to-severe-atopic-dermatitis-patients-and-the-effect-of-biological-therapy
#13
REVIEW
Roselie Achten, Judith Thijs, Marlot van der Wal, Chantal van Luijk, Daphne Bakker, Edward Knol, Matthijs van Luin, Mohsin El Amrani, Eveline Delemarre, Ahmed M I Elfiky, Joke de Boer, Femke van Wijk, Marlies de Graaf, Marjolein de Bruin-Weller
Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new targeted treatments, more insight into the occurrence and pathomechanism of OSD in moderate-to-severe AD patients is needed. Therefore, this review's first part highlights that most patients with moderate-to-severe AD already have characteristics of OSD before starting targeted treatment. Remarkably, not all AD patients with OSD report ocular symptoms...
February 8, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38313568/paclitaxel-induced-periarticular-thenar-erythema-with-onycholysis-syndrome
#14
JOURNAL ARTICLE
Japnoor Kaur, Vishal Gaurav, Mehul Tyagi
INTRODUCTION: Periarticular thenar erythema with onycholysis (PATEO) syndrome is a rare subtype of hand-foot syndrome seen in patients undergoing taxane-based chemotherapy. It presents as erythematous to violaceous plaques on the dorsum of hands, feet, and around the Achilles tendon along with nail changes, particularly onycholysis. CASE PRESENTATION: A 39-year-old female on paclitaxel chemotherapy for stage IIIA (T3N2aM0) invasive ductal breast carcinoma, presented with mildly tender erythematous to violaceous plaques involving the dorsa of bilateral hands and feet, in the periarticular areas of the Achilles tendon, with facial involvement...
February 2024: Skin Appendage Disorders
https://read.qxmd.com/read/38283791/the-association-between-acne-vulgaris-acne-vulgaris-with-nonspecific-facial-dermatitis-and-demodex-mite-presence
#15
JOURNAL ARTICLE
Anon Paichitrojjana, Thep Chalermchai
BACKGROUND: Demodex mites can lead to various skin disorders, from non-specific dermatitis to conditions that mimic other diseases, making it challenging to diagnose accurately. Additionally, it has been reported that Demodex mites can cause skin conditions such as perioral dermatitis, pustular folliculitis, pityriasis folliculorum, blepharitis, and rosacea. Due to conflicting studies, there is a debate regarding the link between Demodex mites and acne vulgaris. This study aims to determine the prevalence of Demodex mites on the faces of individuals with acne vulgaris, acne with nonspecific facial dermatitis, and healthy facial skin to clarify the association...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38282880/observation-of-the-clinical-features-of-dupilumab-associated-facial-erythema
#16
JOURNAL ARTICLE
Hao Wu, Weiming Zhang, Zhongxiao Wu, Yanna Shen, Li Zhang, Mouzhe Yang, Yougang Ren, Feng Mao
INTRODUCTION: Dupilumab is the first biologic agent used to clinically treat moderate and severe atopic dermatitis (AD) and is currently the only biologic agent used for this condition. Many studies have reported that moderate-to-severe AD was significantly improved after dupilumab injection, although head/neck dermatitis occurred with itching, flushing, and scaling. Moreover, because all the symptoms occur after dupilumab treatment, they are called "dupilumab facial redness (DFR)". AIM: To retrospectively analyse the clinical characteristics and treatment of facial erythema in patients with atopic dermatitis treated with dupilumab...
December 2023: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38279067/colchicine-alleviates-rosacea-by-inhibiting-neutrophil-inflammation-activated-by-the-tlr2-pathway
#17
JOURNAL ARTICLE
Xin Yuan, Liang Sheng, Guang Shi, Leiwei Jiang, Chengxiang Lian
Rosacea is a chronic facial inflammatory skin disease that occurs with dysfunction of the immune system. Colchicine was reported to have anti-inflammatory properties. However, the impact of colchicine on rosacea remains unclear. In the present study, the phenotype of rosacea lesions was evaluated by the redness score, inflammatory biomarkers were analyzed by reverse transcription PCR (RT‒PCR), and the infiltration of inflammatory cells was assessed by IHC analysis and immunofluorescence in a rosacea-like mouse model...
January 27, 2024: Inflammation
https://read.qxmd.com/read/38249247/trauma-induced-phaeohyphomycosis-in-an-immunocompetent-host-on-dupilumab
#18
Ishita Aggarwal, David Arps, Edidiong Kaminska
Phaeohyphomycosis is a rare infection caused by dematiaceous fungi containing melanin in their cell wall. Patients are often immunocompromised, and cases seen in immunocompromised hosts have increased in recent years. Dupilumab, a monoclonal antibody against interleukin-4 (IL-4) and interleukin-13 (IL-13) used for the treatment of atopic dermatitis, has been linked to hypersensitivity reactions resulting in facial redness, and there is growing evidence that dupilumab may increase susceptibility to yeast infections as well...
December 2023: Curēus
https://read.qxmd.com/read/38159213/pityriasis-rubra-pilaris-an-updated-review-of-clinical-presentation-etiopathogenesis-and-treatment-options
#19
REVIEW
Tejas P Joshi, Madeleine Duvic
Pityriasis rubra pilaris (PRP) is a rare papulosquamous reaction pattern with a significant impact on quality of life. Type I PRP is the most common PRP variant, presenting as erythematous papules emerging in a follicular distribution and later coalescing into plaques with characteristic islands of sparing; histologically, an alternating pattern of orthokeratosis and parakeratosis is considered the hallmark of PRP (checkerboard hyperkeratosis). Other PRP variants (types II-V) differ in their age of onset and clinical presentation...
March 2024: American Journal of Clinical Dermatology
https://read.qxmd.com/read/38151921/contact-allergy-in-atopic-dermatitis-a-prospective-study-on-prevalence-incriminated-allergens-and-clinical-insights
#20
JOURNAL ARTICLE
Khaoula Trimeche, Ines Lahouel, Hichem Belhadjali, Nesrine Ben Salah, Monia Youssef, Jameleddine Zili
BACKGROUND: The relationship between atopic dermatitis (AD) and allergic contact dermatitis (ACD) is a matter of debate. OBJECTIVES: The purpose of our study is to assess the frequency of ACD in patients with AD, the incriminated allergens and the potential risk factors. METHODS: This is a prospective study, including cases of AD diagnosed based on Hanifin and Rajka's criteria. All patients were patch tested to the European baseline series and corticosteroid series...
December 27, 2023: Contact Dermatitis
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