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https://www.readbyqxmd.com/read/28226272/automated-processing-extraction-and-detection-of-herpes-simplex-virus-types-1-and-2-a-comparative-evaluation-of-three-commercial-platforms-using-clinical-specimens
#1
Matthew J Binnicker, Mark J Espy, Brian Duresko, Cole Irish, Jay Mandrekar
BACKGROUND: Recently, automated platforms have been developed that can perform processing, extraction and testing for herpes simplex virus (HSV) nucleic acid on a single instrument. OBJECTIVES: In this study, we compared three commercially-available systems; Aptima(®)/Panther (Hologic, San Diego, CA), ARIES(®) (Luminex Corporation, Austin, TX), and cobas(®) 4800 (Roche Molecular Systems Inc, Pleasanton, CA) for the qualitative detection of HSV-1/2 in clinical samples...
February 14, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28208927/tuberculosis-of-glans-penis-a-rare-presentation
#2
C Gangalakshmi, Sankaramahalingam
Tuberculosis (TB) of penis is a very rare entity, even in developing countries. It may present as primary or secondary to Pulmonary TB (PTB). Penile TB mimics carcinoma penis, granulomatous penile ulcer, genital herpes simplex, granuloma inguinale and HIV infection. We, hereby, present the case of a 57-year-old male patient who presented to us with ulcerative growth over glans penis and was clinically diagnosed as carcinoma penis, however biopsy of the lesion showed evidence of tuberculosis which was supported by chest X-ray...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28201724/distinct-effects-of-the-cervico-vaginal-microbiota-and-herpes-simplex-type-2-infection-on-female-genital-tract-immunology
#3
B Shannon, P Gajer, T J Yi, B Ma, M S Humphrys, J Thomas-Pavanel, L Chieza, P Janakiram, M Saunders, W Tharao, S Huibner, K Shahabi, J Ravel, R Kaul
No abstract text is available yet for this article.
February 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28198339/sexual-health-of-women-aged-40-and-over-attending-an-inner-city-integrated-sexual-health-clinic
#4
Patrice Grech, Rebecca Marchant, Mannampallil Samuel
Sexual health policy remains focussed on younger adults. However, rates of sexually transmitted infections (STIs) in older people continue to increase. We explored the sexual healthcare needs of women aged 40 and over attending an integrated sexual health clinic in South London. We conducted a retrospective case note review and found that almost 20% of these women had STIs. These included genital herpes, trichomoniasis, genital warts, chlamydia and gonorrhoea. Less than a quarter of women reported use of condoms during most recent sexual contact, indicating sexual risk-taking behaviour...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28198202/clinacanthus-nutans-a-review-on-ethnomedicinal-uses-chemical-constituents-and-pharmacological-properties
#5
Ihsan N Zulkipli, Rajan Rajabalaya, Adi Idris, Nurul Atiqah Sulaiman, Sheba R David
CONTEXT: Medicinal plants have attracted global attention for their hidden therapeutic potential. Clinacanthus nutans (Burm.f) Lindau (Acanthaceae) (CN) is endemic in Southeast Asia. CN contains phytochemicals common to medicinal plants, such as flavonoids. Traditionally, CN has been used for a broad range of human ailments including snake bites and cancer. OBJECTIVES: This article compiles the ethnomedicinal uses of CN and its phytochemistry, and thus provides a phytochemical library of CN...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28197699/-the-alpha-herpesviridae-in-dermatology-herpes-simplex-virus-types%C3%A2-i-and-ii-german-version
#6
REVIEW
L El Hayderi, A Rübben, A F Nikkels
This review on herpes simplex virus type I and type II (HSV-I, HSV-II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV-I infection; HSV-related folliculitis; verrucous HSV-I and HSV-II lesions; the role of recurrent HSV-I infection in burning mouth syndrome; HSV-I and HSV-II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV-I or HSV-II are discussed...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28197698/the-alpha-herpesviridae-in-dermatology-herpes-simplex-virus-types%C3%A2-i-and-ii
#7
REVIEW
L El Hayderi, A Rübben, A F Nikkels
This review on herpes simplex virus type I and type II (HSV‑I, HSV‑II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV‑I infection; HSV-related folliculitis; verrucous HSV‑I and HSV‑II lesions; the role of recurrent HSV‑I infection in burning mouth syndrome; HSV‑I and HSV‑II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV‑I or HSV‑II are discussed...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#8
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28181784/recurrent-herpes-labialis-and-hsv-1-herpes-genitalis-which-is-the-link
#9
Sergio Delmonte, Francesca Sidoti, Simone Ribero, Ivano Dal Conte, Antonio Curtoni, Giulia Ciccarese, Elena Stroppiana, Maria L Stella, Cristina Costa, Rossana Cavallo, Alfredo Rebora, Francesco Drago
BACKGROUND: Recently, Herpes simplex virus (HSV)-1 seroprevalence declined among adolescents, rendering young people lacking HSV-1 antibodies more susceptible to genital HSV-1 acquisition, if sexually exposed. The aim of the present study was to identify the possible risk factors for the development of HSV-1 related herpes genitalis (HG). METHODS: From January 2012 to December 2015, patients with HG attending three Sexually Transmitted Infections Units in Northern Italy were recruited...
February 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28180012/seroprevalence-and-co-infection-of-human-immunodeficiency-virus-hiv-and-herpes-simplex-virus-hsv-among-pregnant-women-in-lokoja-north-central-nigeria
#10
Olatunji Matthew Kolawole, Oluwatomi Olufunke Amuda, Charles Nzurumike, Muhammed Mustapha Suleiman, Jeremiah Ikhevha Ogah
BACKGROUND: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study. OBJECTIVES: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#11
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178213/neurotrophic-factors-ngf-gdnf-and-ntn-selectively-modulate-hsv1-and-hsv2-lytic-infection-and-reactivation-in-primary-adult-sensory-and-autonomic-neurons
#12
Andy A Yanez, Telvin Harrell, Heather J Sriranganathan, Angela M Ives, Andrea S Bertke
Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for survival, some populations cease expression of NGF receptors postnatally, and the viruses preferentially establish latency in different populations of sensory neurons responsive to other neurotrophic factors (NTFs)...
February 7, 2017: Pathogens
https://www.readbyqxmd.com/read/28153513/first-estimates-of-the-global-and-regional-incidence-of-neonatal-herpes-infection
#13
Katharine J Looker, Amalia S Magaret, Margaret T May, Katherine M E Turner, Peter Vickerman, Lori M Newman, Sami L Gottlieb
BACKGROUND: Neonatal herpes is a rare but potentially devastating condition with an estimated 60% fatality rate without treatment. Transmission usually occurs during delivery from mothers with herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) genital infection. However, the global burden has never been quantified to our knowledge. We developed a novel methodology for burden estimation and present first WHO global and regional estimates of the annual number of neonatal herpes cases during 2010-15...
January 30, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28146426/ex-vivo-2d-and-3d-hsv-2-infection-model-using-human-normal-vaginal-epithelial-cells
#14
Yaqi Zhu, Yan Yang, Juanjuan Guo, Ying Dai, Lina Ye, Jianbin Qiu, Zhihong Zeng, Xiaoting Wu, Yanmei Xing, Xiang Long, Xufeng Wu, Lin Ye, Shubin Wang, Hui Li
Herpes simplex virus type 2 (HSV-2) infects human genital mucosa and establishes life-long latent infection. It is unmet need to establish a human cell-based microphysiological system for virus biology and anti-viral drug discovery. One of barriers is lacking of culture system of normal epithelial cells in vitro over decades. In this study, we established human normal vaginal epithelial cell (HNVEC) culture using co-culture system. HNVEC cells were then propagated rapidly and stably in a defined culture condition...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28146109/the%C3%A2-characteristics%C3%A2-of%C3%A2-herpes%C3%A2-simplex%C3%A2-virus%C3%A2-type%C3%A2-1-infection%C3%A2-in%C3%A2-rhesus%C3%A2-macaques%C3%A2-and%C3%A2-the%C3%A2-associated-pathological%C3%A2-features
#15
Shengtao Fan, Hongzhi Cai, Xingli Xu, Min Feng, Lichun Wang, Yun Liao, Ying Zhang, Zhanlong He, Fengmei Yang, Wenhai Yu, Jingjing Wang, Jumin Zhou, Qihan Li
As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1 in rhesus macaques and the pathological features induced during this infection. Clinical symptoms that manifested in the rhesus macaque during HSV1 infection included vesicular lesions and their pathological features. Viral distribution in the nervous tissues and associated pathologic changes indicated the typical systematic pathological processes associated with viral distribution of HSV1...
January 30, 2017: Viruses
https://www.readbyqxmd.com/read/28129372/costing-of-national-sti-program-implementation-for-the-global-sti-control-strategy-for-the-health-sector-2016-2021
#16
Eline L Korenromp, Teodora Wi, Stephen Resch, John Stover, Nathalie Broutet
INTRODUCTION: In 2016 the World Health Assembly adopted the global strategy on Sexually Transmitted Infections (STI) 2016-2021 aiming to reduce curable STIs by 90% by 2030. We costed scaling-up priority interventions to coverage targets. METHODS: Strategy-targeted declines in Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum and Trichomonas vaginalis were applied to WHO-estimated regional burdens at 2012. Syndromic case management was costed for these curable STIs, symptomatic Herpes Simplex Virus 2 (HSV-2), and non-STI vaginal syndromes, with incrementally expanding etiologic diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28120659/first-episode-genital-herpes-interventions-for-men-and-women
#17
Lisa Whitehead
The mission of the Cochrane Nursing Care Field (CNCF) is to improve health outcomes through increasing the use of the Cochrane Library and supporting Cochrane's role by providing an evidence base for nurses and healthcare professionals who deliver, lead or research nursing care. The CNCF produces Cochrane Corner columns, summaries of recent nursing-care-relevant Cochrane Reviews that are regularly published in collaborating nursing-related journals. Information on the processes CNCF has developed can be accessed at: cncf...
January 25, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28103319/an-hsv-2-trivalent-vaccine-is-immunogenic-in-rhesus-macaques-and-highly-efficacious-in-guinea-pigs
#18
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection. We evaluated a trivalent HSV-2 subunit antigen vaccine administered with CpG and alum in rhesus macaques and guinea pigs. The vaccine contains glycoproteins C, D and E (gC2, gD2, gE2) to block virus entry by gD2 and immune evasion by gC2 and gE2. In rhesus macaques, the trivalent vaccine induced plasma and mucosa neutralizing antibodies, antibodies that block gC2 and gE2 immune evasion activities, and stimulated CD4 T cell responses...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28079748/clinical-characteristics-of-herpes-simplex-virus-urethritis-compared-with-chlamydial-urethritis-among-men
#19
Jason J Ong, Anna N Morton, Helen R Henzell, Karen Berzins, Julian Druce, Christopher K Fairley, Catriona S Bradshaw, Tim Rh Read, Jane S Hocking, Marcus Y Chen
BACKGROUND: The aim of this study was to ascertain the clinical characteristics associated with herpes simplex virus (HSV) urethritis in men and to compare those with chlamydial urethritis. METHODS: We compared clinical and laboratory data from men diagnosed with polymerase chain reaction confirmed HSV urethritis with those of men with chlamydial urethritis presenting to Melbourne Sexual Health Centre between 2000 and 2015. RESULTS: Eighty HSV urethritis cases were identified: 55 (68%, 95% confidence interval, 58-78) were by HSV-1 and 25 (32%, 95% confidence interval, 22-42) by HSV-2...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28051084/enrichment-of-herpes-simplex-virus-type-2-hsv-2-reactive-mucosal-t-cells-in-the-human-female-genital-tract
#20
C M Posavad, L Zhao, L Dong, L Jin, C E Stevens, A S Magaret, C Johnston, A Wald, J Zhu, L Corey, D M Koelle
Local mucosal cellular immunity is critical in providing protection from HSV-2. To characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were isolated from endocervical cytobrush and biopsy specimens from 17 HSV-2-infected women and examined ex vivo for the expression of markers associated with maturation and tissue residency and for functional T-cell responses to HSV-2. Compared with their circulating counterparts, cervix-derived CD4+ and CD8+ T cells were predominantly effector memory T cells (CCR7-/CD45RA-) and the majority expressed CD69, a marker of tissue residency...
January 4, 2017: Mucosal Immunology
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