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Genital herpes

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https://www.readbyqxmd.com/read/29140871/hiv-prevalence-and-associated-risk-factors-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania
#1
Elia John Mmbaga, Kåre Moen, Germana Henry Leyna, Rose Mpembeni, Melkizedeck Thomas Leshabari
INTRODUCTION: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming. METHODS: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Data on socio-demographic characteristics and HIV-related risks were collected and all participants were tested for HIV, Herpes Simplex Virus Type-2 (HSV-2), Hepatitis-B Virus (HBV) and Syphilis...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29132771/-neonatal-herpes-epidemiology-clinical-manifestations-and-management-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-and-obstetricians-cngof
#2
L Renesme
OBJECTIVES: To describe the epidemiology of neonatal herpes and its risk factors, clinical and paraclinic manifestations, propose guidelines for a newborn at risk of neonatal herpes, describe treatment modalities, describe post-natal transmission and its prevention. METHODS: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines. RESULTS: Neonatal herpes is rare (about 20 cases per year in France) and mainly due to HSV 1 (level of evidence LE3)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132770/-management-of-pregnant-women-with-recurrent-herpes-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-obstetricians-cngof
#3
O Anselem
OBJECTIVE: To provide guidelines for the management of woman with genital herpes during pregnancy or labor and with known history of genital herpes. METHODS: MedLine and Cochrane Library databases search and review of the main foreign guidelines. RESULTS: Genital herpes ulceration during pregnancy in a woman with history of genital herpes correspond to a recurrence. In this situation, there is no need for virologic confirmation (Grade B). In case of recurrent herpes during pregnancy, antiviral therapy with acyclovir or valacyclovir can be administered but provide low efficiency on duration and severity of symptoms (Grade C)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132769/-genital-herpes-and-pregnancy-serological-and-molecular-diagnostic-tools-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-and-obstetricians-cngof
#4
C Vauloup-Fellous
OBJECTIVES: To describe serological and molecular tools available for genital and neonatal herpes, and their use in different clinical situations. METHODS: Bibliographic investigations from MedLine database and consultation of international clinical practice guidelines. RESULTS: Virological confirmation of genital herpes during pregnancy or neonatal herpes must rely on PCR (Professional consensus). HSV type-specific serology (IgG) will allow determining the immune status of a patient (in the absence of clinical lesions)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132768/pr%C3%A3-vention-et-prise-en-charge-de-l%C3%A2-infection-herp%C3%A3-tique-au-cours-de-la-grossesse-et-de-l%C3%A2-accouchement%C3%A2-recommandations-pour-la-pratique-clinique-%C3%A2-%C3%A2-texte-des-recommandations-texte-court
#5
M-V Sénat, O Anselem, O Picone, L Renesme, N Sananès, C Vauloup-Fellous, Y Sellier, J-P Laplace, L Sentilhes
OBJECTIVE: Identify measures to diagnose, prevent and treat genital herpes infection during pregnancy and childbirth and neonatal infection. METHODS: Bibliographic search from Medline, Cochrane Library databases and research of international clinical practice guidelines. RESULTS: Genital herpes lesion is most often due to HSV2 (LE2). The risk of HSV seroconversion during pregnancy is 1 to 5% (LE2). Genital herpes ulceration during pregnancy in a woman with history of genital herpes corresponds with a recurrence...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29132767/-management-of-pregnant-women-with-first-episode-of-genital-herpes-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-and-obstetricians-cngof
#6
N Sananès
OBJECTIVE: To provide guidelines for the management of first episode genital herpes during pregnancy and in the immediate postpartum period. METHODS: MedLine and Cochrane Library databases search and review of the main foreign guidelines. RESULTS: In case of first episode genital herpes during pregnancy, antiviral treatment with acyclovir (200mg 5 times daily) or valacyclovir (1000mg twice daily) for 5 to 10 days is recommended (grade C)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29069622/intramuscular-delivery-of-replication-defective-herpes-simplex-virus-gives-antigen-expression-in-muscle-syncytia-and-improved-protection-against-pathogenic-hsv-2-strains
#7
Fernando Diaz, Sean Gregory, Hiroshi Nakashima, Mariano S Viapiano, David M Knipe
Herpes simplex virus 2 (HSV-2) is the leading cause of genital herpes and increases the risk of HIV infection, but there is no effective vaccine. A replication-defective HSV-2 mutant virus, dl5-29, is effective in animal models and has been in a phase I trial. Previous studies have shown that dl5-29 gives higher antibody responses and better protection when inoculated intramuscularly (IM) as compared with subcutaneously (SC). However, the basis for this effect has not been defined. We confirmed that IM inoculation of dl5-29 is more immunogenic and provides better protection than SC inoculation...
October 22, 2017: Virology
https://www.readbyqxmd.com/read/29055448/a-case-of-mog-antibody-positive-bilateral-optic-neuritis-and-meningoganglionitis-following-a-genital-herpes-simplex-virus-infection
#8
Masataka Nakamura, Yuko Iwasaki, Toshiyuki Takahashi, Kimihiko Kaneko, Ichiro Nakashima, Takenobu Kunieda, Satoshi Kaneko, Hirofumi Kusaka
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis (ON) and myelitis are recognized as important differential diagnosis of aquaporin-4 (AQP4) antibody-positive neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD). Similar to NMO/NMOSD associated with AQP4 antibodies, preceding infections have been reported in patients with MOG antibody-positive ON. This is the first report of bilateral ON following a herpes simplex virus (HSV) infection associated with a positive MOG antibody...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29052561/a-bayesian-stepwise-discriminant-model-for-predicting-risk-factors-of-preterm-premature-rupture-of-membranes-a-case-control-study
#9
Li-Xia Zhang, Yang Sun, Hai Zhao, Na Zhu, Xing-De Sun, Xing Jin, Ai-Min Zou, Yang Mi, Ji-Ru Xu
BACKGROUND: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of infections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28994129/self-reported-minor-infections-in-patients-with-hidradenitis-suppurativa-and-healthy-controls
#10
P T Riis, H C Ring, R Kjaersgaard Andersen, G B Jemec
BACKGROUND: Patients with hidradenitis suppurativa (HS) often report opportunistic infections such as herpes and urinary tract infections. AIM: To compare opportunistic infections in patients with HS against a group of healthy controls (HCs). METHODS: In total, 99 patients with HS and 109 HCs were recruited at random to this retrospective case-control study. We devised a questionnaire to explore the frequency of minor infections, general practitioner (GP) visits and sick days experienced during the past 6 months...
October 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28979799/network-analysis-of-the-hominin-origin-of-herpes-simplex-virus-2-from-fossil-data
#11
Simon J Underdown, Krishna Kumar, Charlotte Houldcroft
Herpes simplex virus 2 (HSV2) is a human herpesvirus found worldwide that causes genital lesions and more rarely causes encephalitis. This pathogen is most common in Africa, and particularly in central and east Africa, an area of particular significance for the evolution of modern humans. Unlike HSV1, HSV2 has not simply co-speciated with humans from their last common ancestor with primates. HSV2 jumped the species barrier between 1.4 and 3 MYA, most likely through intermediate but unknown hominin species. In this article, we use probability-based network analysis to determine the most probable transmission path between intermediate hosts of HSV2, from the ancestors of chimpanzees to the ancestors of modern humans, using paleo-environmental data on the distribution of African tropical rainforest over the last 3 million years and data on the age and distribution of fossil species of hominin present in Africa between 1...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/28962197/differential-expression-of-mrna-and-mirna-in-guinea-pigs-following-infection-with-hsv2v
#12
Lin Kuang, Yihui Deng, Xiaodan Liu, Zhixiang Zou, Lan Mi
MicroRNAs (miRNAs) are 22-nucleotide single-stranded RNAs which regulate gene expression by targeting 3' untranslated regions. Previous studies have suggested that miRNAs may be used as markers for investigating the molecular regulation of gene expression. In the present study, miRNA and mRNA expression profiles were investigated using a massively parallel next generation sequencing technique to compare herpes simplex virus (HSV)2-infected (n=3) and healthy (n=3) epithelial tissues from guinea pigs. Total RNA was isolated and RNA sequencing was performed using a HiSeq 2000 sequencing system...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28958807/biologic-interactions-between-hsv-2-and-hiv-1-and-possible-implications-for-hsv-vaccine-development
#13
Joshua T Schiffer, Sami L Gottlieb
Development of a safe and effective vaccine against herpes simplex virus type 2 (HSV-2) has the potential to limit the global burden of HSV-2 infection and disease, including genital ulcer disease and neonatal herpes, and is a global sexual and reproductive health priority. Another important potential benefit of an HSV-2 vaccine would be to decrease HIV infections, as HSV-2 increases the risk of HIV-1 acquisition several-fold. Acute and chronic HSV-2 infection creates ulcerations and draws dendritic cells and activated CD4+ T cells into genital mucosa...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28956768/differentiated-sh-sy5y-human-cells-provide-a-reductionist-model-of-hsv-1-neurotropism
#14
Mackenzie M Shipley, Colleen A Mangold, Chad V Kuny, Moriah L Szpara
Neuron-virus interactions that occur during herpes simplex virus (HSV) infection are not fully understood. Neurons are the site of lifelong latency and are a crucial target for long-term suppressive therapy or viral clearance. A reproducible neuronal model of human origin would facilitate studies of HSV and other neurotropic viruses. Current neuronal models in the herpesvirus field vary widely and have caveats including incomplete differentiation, non-human origins, or the use of dividing cells that have neuropotential, but lack neuronal morphology...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28956763/a-novel-role-for-il-17-in-enhancing-type-1-helper-t-cell-immunity-in-the-female-genital-tract-following-mucosal-hsv-2-vaccination
#15
Puja Bagri, Varun C Anipindi, Philip V Nguyen, Danielle Vitali, Martin R Stämpfli, Charu Kaushic
It is well established that interferon-gamma (IFN-γ) production by CD4(+) T cells is critical for anti-viral immunity against herpes simplex virus type 2 (HSV-2) genital infection. However, the role of interleukin-17A (IL-17A) production by CD4(+) T cells in HSV-2 anti-viral immunity is yet to be elucidated. Here, we demonstrate that IL-17A plays an important role in enhancing anti-viral T helper type 1 (Th1) responses in the female genital tract (FGT), and is essential for effective protection conferred by HSV-2 vaccination...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28956417/potential-risk-of-developing-herpes-simplex-encephalitis-in-patients-treated-with-sildenafil-following-primary-exposure-to-genital-herpes
#16
A Goren, J Mccoy, M Kovacevic, M Situm, N Lonky
Herpes simplex encephalitis (HSE) is associated with significant mortality and morbidity. As a consequence of HSE, up to 75% of infected individuals die or experience irreversible neurological damage. While the pathogenesis of the disease is unknown, it is traditionally hypothesized that the viral infection occurs by neuronal transmission directly from peripheral sites. Non-neuronal modes of infection have generally been overlooked as the brain is protected by the blood-brain-barrier (BBB). The BBB poses an effective barrier to pathogens as well as to drugs such as chemotherapies...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28954091/beh%C3%A3-et-s-disease-review-with-emphasis-on-dermatological-aspects
#17
REVIEW
Maria Antonieta Rios Scherrer, Vanessa Barreto Rocha, Lucas Campos Garcia
Behçet's disease is a systemic vasculitis characterized by attacks of acute inflammation, which can affect almost every vascularized area of the body. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis there are indications of genetic susceptibility associated with environmental influence. Among the involved genes are those that encompass innate and adaptive immunities. Polymorphisms and epistatic interactions in several genes are described, as well as the presence of imbalance lineage between HLA-B51 and A (MICA)...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28953412/sexually-transmitted-infections-active-component-u-s-armed-forces-2007-2016
#18
Shauna Stahlman, Alexis A Oetting
This report summarizes incidence rates of the five most commonly diagnosed sexually transmitted infections (STIs) among active component service members of the U.S. Armed Forces during 2007-2016. Chlamydia diagnoses were the most common, followed in decreasing order of frequency by diagnoses associated with genital human papillomavirus (HPV), gonorrhea, herpes simplex virus (HSV), and syphilis. Compared to men, women had higher rates of all STIs except for syphilis. In general, compared to their respective counterparts, younger service members, non-Hispanic blacks, soldiers, and enlisted members had higher incidence rates of STIs...
September 2017: MSMR
https://www.readbyqxmd.com/read/28947407/skin-diseases-of-the-male-external-genitalia-in-the-tanlangai-hospital-in-brazzaville-congo
#19
E S Bayonne Kombo, A Gathse, R B Soussa, A W S Odzebe
To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. The data were processed with Epi Info 3.5.4 software. The records revealed 76 dermatoses of the male external genitalia treated in the three-year study period...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28931680/molecular-evolution-of-herpes-simplex-virus-2-complete-genomes-comparison-between-primary-and-recurrent-infections
#20
Miguel A Minaya, Travis Jensen, Johannes Goll, Maria Korom, Sree H Datla, Robert B Belshe, Lynda A Morrison
Herpes simplex virus (HSV)-1 and -2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of reactivation over time is not known. We determined genome sequences of viruses isolated from two subjects in the Herpevac Trial for Women who experienced primary HSV-2 genital disease and compared them with sequences of viruses isolated from the subsequent fifth or sixth episode of recurrent disease in the same individuals...
September 20, 2017: Journal of Virology
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