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Genital herpes

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https://www.readbyqxmd.com/read/28079748/clinical-characteristics-of-herpes-simplex-virus-urethritis-compared-with-chlamydial-urethritis-among-men
#1
Jason J Ong, Anna N Morton, Helen R Henzell, Karen Berzins, Julian Druce, Christopher K Fairley, Catriona S Bradshaw, Tim Rh Read, Jane S Hocking, Marcus Y Chen
BACKGROUND: The aim of this study was to ascertain the clinical characteristics associated with herpes simplex virus (HSV) urethritis in men and to compare those with chlamydial urethritis. METHODS: We compared clinical and laboratory data from men diagnosed with polymerase chain reaction confirmed HSV urethritis with those of men with chlamydial urethritis presenting to Melbourne Sexual Health Centre between 2000 and 2015. RESULTS: Eighty HSV urethritis cases were identified: 55 (68%, 95% confidence interval, 58-78) were by HSV-1 and 25 (32%, 95% confidence interval, 22-42) by HSV-2...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28051084/enrichment-of-herpes-simplex-virus-type-2-hsv-2-reactive-mucosal-t-cells-in-the-human-female-genital-tract
#2
C M Posavad, L Zhao, L Dong, L Jin, C E Stevens, A S Magaret, C Johnston, A Wald, J Zhu, L Corey, D M Koelle
Local mucosal cellular immunity is critical in providing protection from HSV-2. To characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were isolated from endocervical cytobrush and biopsy specimens from 17 HSV-2-infected women and examined ex vivo for the expression of markers associated with maturation and tissue residency and for functional T-cell responses to HSV-2. Compared with their circulating counterparts, cervix-derived CD4+ and CD8+ T cells were predominantly effector memory T cells (CCR7-/CD45RA-) and the majority expressed CD69, a marker of tissue residency...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28042218/a-comparative-analysis-of-polymerase-chain-reaction-and-direct-fluorescent-antibody-test-for-diagnosis-of-genital-herpes
#3
Vrushali Patwardhan, Preena Bhalla, Deepti Rawat, Vijay Kumar Garg, Kabir Sardana, Sumit Sethi
OBJECTIVE: To compare laboratory tests that can simultaneously detect and type herpes simplex virus (HSV) directly from the genital ulcer specimens in clinically suspected cases of genital herpes. MATERIALS AND METHODS: A study was conducted over 10 months and 44 adult male and female patients clinically suspected with genital herpes were recruited. Genital ulcer swab specimens were subjected to glycoprotein-G gene-based conventional polymerase chain reaction (PCR) and commercially available direct fluorescent antibody (DFA) test and the results were compared...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28009539/sexual-temptation-substance-abuse-no-sex-safe-sex-risky-sex-and-stds
#4
Toto Sutarso, Thomas Li-Ping Tang, Denny R Anerin, Intan W S McCartt, Courtney B Gibson
BACKGROUND: University students' substance abuse and risky sex contribute to sexually transmitted diseases (STDs). PURPOSE: We develop and empirically test a formative theoretical model of sexual temptation involving substance abuse (cigarettes, alcohol, and marijuana), safe sexual behavior (use of condom/barrier for oral and vaginal intercourse), risky sexual behavior (unprotected sex and multiple sexual partners), and STDs: gonorrhea, HIV, and genital herpes. We simultaneously explore these constructs, controlling membership in social groups (fraternity/sorority, varsity athlete, and club sports) and perceived norm of substance abuse...
December 23, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27997660/serologic-screening-for-genital-herpes-an-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#5
Cynthia Feltner, Catherine Grodensky, Charles Ebel, Jennifer C Middleton, Russell P Harris, Mahima Ashok, Daniel E Jonas
Importance: Genital herpes simplex virus (HSV) infection is a prevalent sexually transmitted infection. Vertical transmission of HSV can lead to fetal morbidity and mortality. Objective: To assess the evidence on serologic screening and preventive interventions for genital HSV infection in asymptomatic adults and adolescents to support the US Preventive Services Task Force for an updated recommendation statement. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries through March 31, 2016...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27997659/serologic-screening-for-genital-herpes-infection-us-preventive-services-task-force-recommendation-statement
#6
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Michael Silverstein, Chien-Wen Tseng
Importance: Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Neonatal herpes infection, while uncommon, can result in substantial morbidity and mortality. Objective: To update the 2005 US Preventive Services Task Force (USPSTF) recommendation on screening for genital herpes...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27997655/jama-patient-page-screening-for-genital-herpes
#7
Jill Jin
No abstract text is available yet for this article.
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27997653/effect-of-pritelivir-compared-with-valacyclovir-on-genital-hsv-2-shedding-in-patients-with-frequent-recurrences-a-randomized-clinical-trial
#8
Anna Wald, Burkhard Timmler, Amalia Magaret, Terri Warren, Stephen Tyring, Christine Johnston, Kenneth Fife, Stacy Selke, Meei-Li Huang, Hans-Peter Stobernack, Holger Zimmermann, Lawrence Corey, Alexander Birkmann, Helga Ruebsamen-Schaeff
Importance: Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV) helicase-primase inhibitor that reduced genital shedding and lesions. Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection. Design, Setting, and Participants: A phase 2, randomized, double-blind, crossover clinical trial at clinical research centers in 4 US cities (October 2012-July 2013) compared daily oral doses of 100 mg of pritelivir with 500 mg of valacyclovir...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27997636/a-recommendation-against-serologic-screening-for-genital-herpes-infection-what-now
#9
EDITORIAL
Edward W Hook
No abstract text is available yet for this article.
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27997634/screening-for-genital-herpes-what-is-not-to-be-done
#10
Kenneth A Katz
No abstract text is available yet for this article.
December 20, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27984553/prevalence-and-predictors-of-human-immunodeficiency-virus-and-selected-sexually-transmitted-infections-among-people-who-inject-drugs-in-dar-es-salaam-tanzania-a-new-focus-to-get-to-zero
#11
Elia John Mmbaga, Kåre Moen, Neema Makyao, Melkizedeck Leshabari
BACKGROUND: Previous studies in Tanzania indicated that human immunodeficiency virus (HIV) prevalence among people who inject drugs (PWIDs) could be as high as 40%. We aim to provide data on the prevalence of HIV and sexually transmitted infection among PWIDs to inform national plans to get to zero. MATERIALS AND METHODS: Respondent-driven sampling was used to collect drug use, and sexual practices data among PWIDs aged 15 years and older. Blood samples were examined for HIV, herpes simplex virus type 2, syphilis, and hepatitis B...
December 14, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27974365/nk-cells-require-antigen-specific-memory-cd4-t-cells-to-mediate-superior-effector-functions-during-hsv-2-recall-responses-in-vitro
#12
Branson Chen, Amanda J Lee, Marianne V Chew, Ali A Ashkar
Natural killer (NK) cells have an important role in mounting protective innate responses against genital herpes simplex virus type 2 (HSV-2) infections. However their role as effectors in adaptive immune responses against HSV-2 is unclear. Here, we demonstrate that NK cells from C57BL/6 mice in an ex vivo splenocyte culture produce significantly more interferon γ (IFN-γ) upon re-exposure to HSV-2 antigens in a mouse model of genital HSV-2 immunization. We find that naïve NK cells do not require any prior stimulation or priming to be activated to produce IFN-γ...
December 14, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27959657/genital-herpes
#13
LETTER
Chitra Akileswaran, Deborah Cohan
No abstract text is available yet for this article.
10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959656/genital-herpes
#14
LETTER
(no author information available yet)
No abstract text is available yet for this article.
10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27942584/ifn-%C3%AE%C2%B5-protects-primary-macrophages-against-hiv-infection
#15
Carley Tasker, Selvakumar Subbian, Pan Gao, Jennifer Couret, Carly Levine, Saleena Ghanny, Patricia Soteropoulos, Xilin Zhao, Nathaniel Landau, Wuyuan Lu, Theresa L Chang
IFN-ε is a unique type I IFN that is not induced by pattern recognition response elements. IFN-ε is constitutively expressed in mucosal tissues, including the female genital mucosa. Although the direct antiviral activity of IFN-ε was thought to be weak compared with IFN-α, IFN-ε controls Chlamydia muridarum and herpes simplex virus 2 in mice, possibly through modulation of immune response. We show here that IFN-ε induces an antiviral state in human macrophages that blocks HIV-1 replication. IFN-ε had little or no protective effect in activated CD4(+) T cells or transformed cell lines unless activated CD4(+) T cells were infected with replication-competent HIV-1 at a low MOI...
December 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27927863/longitudinal-viral-dynamics-in-semen-during-early-hiv-infection
#16
Sheldon R Morris, Mitchell Zhao, Davey R Smith, Milenka V Vargas, Susan J Little, Sara Gianella
BACKGROUND: Multiple viruses co-infect the male genital tract, influencing each other's replication and perhaps affecting HIV pathogenesis and disease progression. METHODS: This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San Diego Primary Infection Cohort and 67 seminal samples from HIV-negative healthy controls. Seminal HIV RNA and DNA from seven human herpesviruses (HHV) were measured by RT-PCR. Longitudinal shedding rates were determined by Kaplan-Meier survival analysis...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27922851/future-prospects-for-new-vaccines-against-sexually-transmitted-infections
#17
Sami L Gottlieb, Christine Johnston
PURPOSE OF REVIEW: This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis). RECENT FINDINGS: Global estimates suggest that more than a million STIs are acquired every day, and many new and emerging challenges to STI control highlight the critical need for development of new STI vaccines...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27903680/herpes-simplex-virus-specific-t-cell-response-in-a-cohort-with-primary-genital-infection-correlates-inversely-with-frequency-of-subsequent-recurrences
#18
Elisabeth Franzen-Röhl, Danika Schepis, Fredrik Atterfelt, Kristina Franck, Arne Wikström, Jan-Åke Liljeqvist, Tomas Bergström, Elisabeth Aurelius, Klas Kärre, Louise Berg, Hans Gaines
OBJECTIVES: During the last decades, a changing epidemiological pattern of genital herpes simplex virus (HSV) infection has emerged. Primary infection is now caused as often by HSV-1 as by HSV-2. Once established, HSV can be reactivated leading to recurrent mucocutaneous lesions as well as meningitis. Why some otherwise immune-competent individuals experience severe and frequent recurrences is not known, and the immunological mechanism underlying recurrent symptomatic HSV infection is not fully understood...
November 30, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27890958/nonhealing-genital-ulcer-in-aids-a-diagnostic-dilemma
#19
Yogesh S Marfatia, Devi Sathianadha Menon, Sheethal Jose, Brijesh Kumar Patel
HIV/AIDS-related immune alteration poses many diagnostic and therapeutic challenges. HIV-positive 44-year-old male, on second-line antiretroviral therapy (ART) presented with asymptomatic non healing, well-defined, erythematous ulcer over penis since 8 months with serosanguinous discharge. Inguinal lymph nodes were not palpable. Tzanck smear was negative. Biopsy was not done as the patient was not willing for the same. Acyclovir was given considering herpes infection to which there was no response, and hence azithromycin and metronidazole were given, without improvement...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27868164/efficient-production-of-recombinant-glycoprotein-d-of-herpes-simplex-virus-type-2-in-pichia-pastoris-and-its-protective-efficacy-against-viral-challenge-in-mice
#20
Man Wang, Shuai Jiang, Li Zhou, Chaoqun Wang, Ruifeng Mao, Murugavel Ponnusamy
Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital ulcer disease and a significant public health concern. However, there are no approved vaccines available to prevent HSV-2 infection. The glycoprotein D (gD) of HSV-2 is the most important candidate antigen for vaccine development. In this study, a truncated form of gD (codons 1-340, gD1-340) was produced as a secretory protein in the methylotrophic yeast Pichia pastoris. The recombinant gD1-340 with a His6 tag was purified to homogeneity by one-step affinity chromatography...
November 21, 2016: Archives of Virology
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