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Condyloma acuminatum

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https://www.readbyqxmd.com/read/27872135/successful-improvement-of-buschke-l%C3%A3-wenstein-tumour-in-an-hiv-infected-patient-with-antiretroviral-therapy-alone
#1
Camille Grodner, Aurélia Henn, Jean-Daniel Lelièvre, Sébastien Gallien
Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention...
November 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27819643/giant-perineal-condyloma-acuminatum-buschke-lowenstein-tumour-a-case-report
#2
D C Badiu, C A Manea, M Mandu, V Chiperi, I E Marin, C Mehedintu, C C Popa, O I David, E Bratila, V T Grigorean
The giant condyloma acuminatum, also known as Buschke- Lowenstein tumor (BLT), is a rare sexually-transmitted disease. Moreover, the condyloma acuminatum produced by Human Papilloma Virus (HPV) infection becomes one the most common sexually-transmitted infection which affects the perineal region. Under such situations, the first therapeutic option is surgical excision. The objective of this article is to present a case in which the tumor has reached giant dimensions and also to stress the importance of an in toto resection, taking into account the high rate of recurrence and the significant potential of malignant transformation of BLT...
2016: Chirurgia
https://www.readbyqxmd.com/read/27801758/metastatic-urothelial-carcinoma-to-the-uterine-cervix-a-case-report-of-a-rare-entity-and-review-of-the-diagnostic-differential
#3
Sharon B Sams, Julie A Rosser
Urothelial carcinoma (UC) rarely metastasizes to the gynecologic tract, occurring in descending order of frequency, within the vagina, uterus, ovaries, and cervix. Significant morphologic overlap exists between primary gynecologic squamous lesions (both benign and malignant) and metastatic UC, thus potentially hindering a timely and accurate diagnosis. We present a case of UC metastatic to the uterine cervix in a 69-year-old female initially found to have noninvasive high-grade papillary UC of the bladder. Complaints of vaginal spotting lead to identification and biopsy of a mass in the uterine cervix...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27716987/efficacy-of-imidazolquinoline-on-treatment-of-condyloma-acuminatum-of-the-buccal-mucosa
#4
Davi Silva Carvalho Curi, Patrícia Miranda Leite-Ribeiro, Vinicius Rabelo Torregrossa, Vinicius Costa Vieira, Viviane Almeida Sarmento
The condylomata acuminata is a benign epithelial neoplasm induced by papillomavirus, and it is characterized by the proliferation of stratified squamous epithelial tissue that affects the anogenital and oral mucosa. It is considered to be a sexually transmitted disease and has a higher prevalence in individuals infected with human immunodeficiency virus. Various therapies have been used for the removal of lesions, such as cryotherapy, surgical laser and surgical excision, which are painful and scarring. These techniques, however, do not eliminate the virus and relapses are common shortly after treatment...
September 26, 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/27659432/risk-factors-for-urethral-condyloma-among-heterosexual-young-male-patients-with-condyloma-acuminatum-of-penile-skin
#5
Jong Kwan Park, Yu Seob Shin
To our knowledge, this is the first study that focuses on risk factor of urethral condyloma (UC). The subjects of our study included genital warts patients who had been diagnosed as having condyloma acuminatum of penile skin (CAPS) with/without UC. Relationship with UC of number of life time female partners, co-infection with urethritis, circumcision status, number of CAPS and wart diameter were studied by use of multivariate analysis. Co-infection with urethritis, circumcision status were risk factors of UC in heterosexual young male patients with CAPS...
September 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27551519/transcription-factor-7-like-1-dysregulates-keratinocyte-differentiation-through-upregulating-lipocalin-2
#6
M Xu, Y Zhang, H Cheng, Y Liu, X Zou, N Zhan, S Xiao, Y Xia
Recent studies strongly suggested that transcription factor 7-like 1 (Tcf7l1, also known as Tcf3) is involved in the differentiation of several types of cells, and demonstrated that Tcf7l1 modulates keratinocytes physiologically through regulating lipocalin 2 (LCN2), a key regulator of cell differentiation. To reveal the potential role of Tcf7l1 in the dysregulation of keratinocyte differentiation, both Tcf7l1 and LCN2 were determined in a variety of skin disorders. The in vitro effect of Tcf7l1 on keratinocyte differentiation was studied by culturing SCC-13 cells, and the human foreskin keratinocytes (HFKs) that were transfected with vectors for overexpressing human papillomavirus E6/E7 or Tcf7l1 genes...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27335781/giant-condyloma-acuminatum-in-the-genital-perineal-and-perianal-region-in-a-pediatric-patient-literature-review-and-case-report
#7
Rodrigo Suárez-Ibarrola, Alexander Heinze, Fabian Sánchez-Sagástegui, Atziri Negrin-Ramírez, Roberto Aguilar-Anzures, Luis Xochihua-Diaz, Juan Osvaldo Cuevas-Alpuche
Condyloma acuminata is caused by the proliferation of squamous epithelial cells in the presence of human papilloma virus (HPV) infection. There are several treatment options available for anogenital warts, however, none have proven to be more efficacious. We present the case of a 3 year-8 months-old male, diagnosed with human immunodeficiency virus (HIV) infection, who presented with multiple warts in the anogenital region. Lesions were treated with imiquimod 5%, electrosurgical resection and interferon α-2b...
July 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27331134/acquired-vulvar-lymphangioma-circumscriptum-after-cervical-cancer-treatment-case-report
#8
Kari Valente, Kathleen Montgomery, Stephen Schultenover, Mohamed Mokhtar Desouki
Vulvar lymphangioma circumscriptum (LC) is a rare entity which may present as a painful, warty lesion. In contrast to the congenital form, which occurs in children, the acquired form arises in older adults and may be associated with infection, Crohn's disease, or prior pelvic/regional surgery. We present a case of acquired LC of the vulva in a 55-year-old woman who presented with a 3-4 year history of vulvar pain following chemotherapy, radiation, and brachytherapy for cervical cancer. Vulvar shave biopsies followed by excision revealed a thickened dermis with epidermal hyperkeratosis, parakeratosis, elongated rete ridges and dilated lymphatic channels containing eosinophilic material and scattered thrombi...
April 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27175598/integrity-of-a-hpv11-infection-cell-model-and-identification-of-epigallocatechin-3-gallate-as-a-potential-hpv11-inhibitor
#9
Yang Sun, Xinyu Li, Shasha Song, Yongfang Wang, Heng Gu
BACKGROUND: Condyloma acuminatum (CA) is one of the most common sexually transmitted diseases and induced by low-risk human papillomaviruses (HPVs), mainly HPV type 6 and 11. Here, we report the identification of (-)-Epigallocatechin-3-gallate (EGCG) by an HPV11 infection cell model. RESULTS: The recombined HPV11.HaCaT cells had stable HPV 11 early genes expression. The introducing of HPV11 genome significantly increased the proliferation of HPV11.HaCaT cells, as well as the proportion of cells in S and G2/M phases...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27009931/sex-differences-in-the-incidence-of-skin-and-skin-related-diseases-in-olmsted-county-minnesota-united-states-and-a-comparison-with-other-rates-published-worldwide
#10
REVIEW
Louise K Andersen, Mark D P Davis
Many skin and skin-related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin-related diseases affecting males vs. females, we reviewed published population-based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers...
September 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26937152/condyloma-acuminatum-of-the-anal-canal-treated-with-endoscopic-submucosal-dissection
#11
Akiko Sasaki, Takeshi Nakajima, Hideto Egashira, Kotaro Takeda, Shinnosuke Tokoro, Chikamasa Ichita, Sakue Masuda, Haruki Uojima, Kazuya Koizumi, Takeshi Kinbara, Taku Sakamoto, Yutaka Saito, Makoto Kako
Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments (trans-anal resection and trans-anal endoscopic microsurgery) and immunotherapeutic and topical methods (topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection (ESD)...
February 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26802960/giant-condyloma-acuminatum-of-the-scrotum-bilateral-groins-and-suprapubic-region-a-treatment-and-reconstruction-challenge
#12
Joseph Ogrodnik, Salil Gulati, Juvonda Hodge, Cassidy Koonce
No abstract text is available yet for this article.
May 2015: American Surgeon
https://www.readbyqxmd.com/read/26547888/perianal-pyoderma-gangrenosum-after-excision-and-fulguration-of-anal-condyloma-acuminatum
#13
Jennifer L Agnew, Paul D Strombom, Carmen F Fong, Timothy J Kelly, Joseph E Martz
INTRODUCTION: Pyoderma gangrenosum (PG) is a rare, inflammatory skin pathology frequently associated with systemic inflammatory disease. While rare after surgery, recognition of this disease in the post-surgical setting is important as it can mimic wound infection. PRESENTATION OF CASE: We herein present a dramatic presentation of perianal PG four days after routine excision and fulguration of anal condyloma acuminatum. The affected area did not improve with broad spectrum antibiotics or surgical debridement...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26475783/correlation-of-human-papillomavirus-types-with-clinical-features-of-patients-with-condyloma-acuminatum-in-china
#14
Xianling Cong, Ran Sun, Xuewen Zhang, Yuqian Wang, Liying Wang, Yongli Yu
BACKGROUND: Condyloma acuminatum (CA)-related human papillomavirus (HPV) typing has focused on the prevalence of HPV types. The correlation between HPV types and the clinical features of CA has rarely been documented. AIMS: The purpose of this study was to investigate the relationship between HPV types and the clinical features of CA. METHODS: Polymerase chain reaction-restriction fragment length polymorphism was used to type HPV in the CA lesions from 80 Chinese patients with full clinical data...
July 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26442297/-correlation-of-tlr2-and-tlr4-gene-polymorphisms-with-the-susceptibility-and-recurrence-of-condyloma-acuminatum
#15
Ji-feng Liu, Bin Qu, Xiang-dong Wang, Qi Wang, Xiao-xia Zhao, Ai-e Xu
OBJECTIVE: To explore the correlation of the gene polymorphisms of Toll-like receptor 2 ( TLR2) and TLR4 with the susceptibility and recurrence of condyloma acuminatum (CA). METHODS: Using Snapshot, we detected the gene polymorphisms of TLR2 597(T/C), 1350(T/C), 15607(A/G), and 2258(G/A) and TLR4 896(A/G) and 1196(C/T) in the peripheral blood of 140 CA patients and 105 HPV-negative controls. We made comparisons between the CA patients and controls as well as between the cases of recurrent CA and those of non-recurrence at 6 months after treatment...
August 2015: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/26366507/rapidly-invasive-buschke-l%C3%A3-wenstein-tumor-associated-with-human-papillomavirus-types-6-and-52
#16
Marco Diani, Vinicio Boneschi, Stefano Ramoni, Franco Gadda, Alessandro Del Gobbo, Marco Cusini
Buschke-Löwenstein tumor, or giant condyloma acuminatum, represents a rare, sexually transmitted disorder, with a slow evolution and the tendency to infiltrate in the adjacent tissues associated with human papillomavirus (HPV). This article reports the first case of male Buschke-Löwenstein tumor associated with HPV6 and HPV52.
October 2015: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/26349339/-a-case-of-juvenile-onset-laryngeal-papillomatosis-requiring-emergency-airway-management
#17
Yoshihiro Akazawa, Aibi Akashi, Masatoshi Akutsu, Koushi Mikami, Masahiko Fukasawa, Shigeru Kasugai, Miki Sakamoto, Izumi Koizuka
Juvenile-onset laryngeal papillomatosis has a serious tendency for rapid growth and repeated recurrence. Thus, patience and prudence are required for the successful management of this pathology. We report herein on 2-year and 4-month-old boy with juvenile-onset laryngeal papillomatosis, which caused remarkable airway constriction that required urgent airway management. He was delivered vaginally by a mother with condyloma acuminatum. Hoarseness appeared at 1 year of age, and retractive breathing was observed at 1 year and 6 months of age...
March 2015: Nihon Jibiinkoka Gakkai Kaiho
https://www.readbyqxmd.com/read/26297545/mir-99b-suppresses-igf-1r-expression-and-contributes-to-inhibition-of-cell-proliferation-in-human-epidermal-keratinocytes
#18
Jingrong Li, Ruihua Fang, Qing Gong, Jianqin Wang
Condyloma acuminatum (CA) is a condition caused by the highly contagious human papillomavirus (HPV), characterized by warts that undergo abnormal cell proliferation. One of the important regulators of cell proliferation is microRNAs (miRNAs). In this study, we aimed to investigate the expression profile of miR-99b in HPV positive CA samples and normal skin. We found significantly lower miR-99b levels in CA samples than in normal skin. Therefore, we investigated the role of miR-99b in regulating the proliferation of primary cultured human epidermal keratinocytes, and found that forced expression of miR-99b inhibited proliferation and induced G1-phase arrest...
October 2015: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/26284185/giant-condyloma-acuminatum-of-vulva-frustrating-treatment-challenge
#19
Feizollah Niazy, Khalil Rostami, Amir Reza Motabar
Giant condylomata are not usually seen nowadays in developed nations, but such cases are still seen in the under-resourced countries. Condylomata acuminata are commonly transmitted through sexual intercourse. Generally diagnosed based on their appearance. Giant condyloma acuminata also named Buschke- Löwenstein tumour (BLT) is a slow growing cauliflower-like tumor, locally aggressive and destructive, with possible malignant transformation. Common clinical treatment of anogenital warts is conservative, however, in extreme cases conservative therapy is insufficient and surgical excision is required...
July 2015: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/26195964/successful-surgical-management-of-giant-condyloma-acuminatum-buschke-lowenstein-tumor-in-the-urethra-of-a-female-patient-a-case-report
#20
Michael Nordsiek, Curtis Ross, Michael Metro
The Buschke-Lowenstein tumor (BLT) is a slow-growing, locally destructive verrucous plaque that typically appears on the penis but may occur elsewhere in the anogenital region. It most commonly is considered to be a regional variant of verrucous carcinoma. It is rare but accounts for 5-24% of all penile cancers. It can also affect the perineum and other portions of the genitalia. It was first described by Buschke and Löwenstein in 1925, and is also known as giant condyloma acuminatum (GCA). Regardless of the treatment modality, careful follow-up is recommended because of the high risk of recurrence and the possibility for malignant transformation in 30-56% of patients...
May 2015: Current Urology
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