O6

Fluorescent chemosensors offer a direct means of measuring enzyme activity for cancer diagnosis, predicting drug resistance, and aiding in the discovery of new anticancer drugs. O6 -methylguanine DNA methyltransferase (MGMT) is a predictor of resistance towards anticancer alkylating agents such as temozolomide. Using the fluorescent molecular rotor, 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ), we synthesized, and evaluated a MGMT fluorescent chemosensor derived from a chloromethyl-triazole covalent inhibitor, AA-CW236, a non-pseudosubstrate of MGMT...

The chlorine evolution reaction (CER) is essential for industrial Cl2 production but strongly relies on the use of dimensionally stable anode (DSA) with high-amount precious Ru/Ir oxide on a Ti substrate. For the purpose of sustainable development, precious metal decrement and performance improvement are highly desirable for the development of CER anodes. Herein, we demonstrate that surface titanium oxide amorphization is crucial to regulate the coordination environment of stabilized Ir single atoms for efficient and durable chlorine evolution of Ti monolithic anodes...

This paper explores the connection between the H3 BO3 flux concentration and the co-existence of Eu2+ and Eu3+ dopants within CaMgSi2 O6 crystals (diopside). The samples were synthesised using a solid-state synthesis method under varying atmospheric conditions, including oxidative (air), neutral (N2 ), and reductive (H2 /N2 mixture) environments. Additionally, some materials underwent chemical modification by partially substituting Si4+ with Al3+ ions acting as charge compensation defects stabilizing Eu3+ luminescence...

Titanium-oxo cluster (TOC)-based metal-organic frameworks (MOFs) have received considerable attention in recent years due to their ability to expand the application of TOCs to fields that require highly stable frameworks. Herein, a new cyclic TOC formulated as [Ti6 O6 (O i Pr)8 (TTFTC)(phen)2 ]2 ( 1 , where TTFTC = tetrathiafulvalene tetracarboxylate and phen = phenanthroline) was crystallographically characterized. TOC 1 takes a rectangular ring structure with two phen-modified Ti6 clusters as the width and two TTFTC ligands as the length...

BACKGROUND: In the randomized phase II REGOMA trial, regorafenib showed promising activity in patients with recurrent glioblastoma. We conducted a large, multicenter, prospective, observational study to confirm the REGOMA data in a real-world setting. PATIENTS AND METHODS: The major inclusion criteria were histologically confirmed diagnosis of glioblastoma according to the World Health Organization (WHO) 2016 classification and relapse after radiotherapy with concurrent/adjuvant temozolomide treatment, good performance status [Eastern Cooperative Oncology Group performance status (ECOG PS 0-1)] and good liver function...

The efficacy of temozolomide (TMZ) treatment in glioblastoma (GBM) is influenced by various mechanisms, mainly including the level of O6 -methylguanine-DNA methyltransferase (MGMT) and the activity of DNA damage repair (DDR) pathways. In our previous study, we had proved that long non-coding RNA HOTAIR regulated the GBM progression and mediated DDR by interacting with EZH2, the catalytic subunit of PRC2. In this study, we developed a small-molecule inhibitor called EPIC-0628 that selectively disrupted the HOTAIR-EZH2 interaction and promoted ATF3 expression...

We have used high-pressure synthesis to synthesize samples of Ca2- x Mn x Ti2 O6 double perovskite, where x varies between 0.2 and 1. The synthesized materials were structurally characterized with powder X-ray diffraction (XRD). Rietveld refinement of the XRD patterns was used to study the change from CaTiO3 ( x = 0) to the composition CaMnTi2 O6 ( x = 1) where half of the Ca(II) ions are replaced by smaller Mn(II) ions. We analyzed the peak shapes in the XRD patterns, as well as lattice parameters, and it appears that smooth symmetry change from the centrosymmetric space group Pbnm to the non-centrosymmetric space group P 42 mc occurs between x = 0...

The discovery of novel organic-inorganic hybrid nonlinear optical (NLO) crystal materials holds great potential in advancing laser science and technology as they offer a wide range of benefits including easy synthesis, structural versatility, and high hyperpolarizability. Herein, the integration of l-tartaric acid (L-C4 H6 O6 ) and ZnSO4 gave rise to two acentric Zn-based organic-inorganic hybrid crystals, namely, Zn2 (H2 O)2 (C4 H4 O6 )2 ·3H2 O ( Zn-LT ) and Zn2 (H2 O)(C4 H4 O6 )(C4 H6 O6 )(SO4 )·4H2 O ( Zn-LTS )...

Thermal characteristics are essential for improving the performance and monitoring the status of Li-ion batteries (LIB). However, it is a challenge to design efficient and facile sensing materials for the detection of in-situ temperature of a working LIB. Herein, we develop a ratiometric fluorescence optical fiber and perform real-time temperature monitoring with a measurement accuracy of 0.12 °C, and the feasibility based on this polymer optical fiber composed of NaLaTi2 O6 :Yb/Er phosphors is verified in a pouch-type battery...

In this research article, two multicopper [Cu3 ] and [Cu6 ] clusters, [Cu3 (cpdp)(μ3 -SO4 )(Cl)(H2 O)2 ]·3H2 O ( 1 ) and [Cu6 (cpdp)2 (μ2 -O)(Cl)2 (H2 O)4 ]·2Cl ( 2 ) (H3 cpdp = N , N '-bis[2-carboxybenzomethyl]- N , N '-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol), have been explored as potent antibacterial and antibiofilm agents. Their molecular structures have been determined by a single-crystal X-ray diffraction study, and the compositions have been established by thermal and elemental analyses, including electrospray ionization mass spectrometry...

A new bis-Schiff base (L) Ca(II) complex, CaL, was synthesized by the reaction of calcium perchlorate tetrahydrate, 1,3-diamino-2-hydroxypropane, and 2-formyl phenoxyacetic acid in an ethanol-water (v:v = 2:1) solution and characterized by IR, UV-vis, TG-DTA, and X-ray single crystal diffraction analysis. The structural analysis indicates that the Ca(II) complex crystallizes in the monoclinic system, space group P 121 / n 1, and the Ca(II) ions are six-coordinated with four O atoms (O8, O9, O11, O12, or O1, O2, O4, O6) and two N atoms (N1, N2, or N3, N4) of one bis-Schiff base ligand...

PURPOSE: This study aimed to perform multimodal analysis by vision transformer (vViT) in predicting O6-methylguanine-DNA methyl transferase (MGMT) promoter status among adult patients with diffuse glioma using demographics (sex and age), radiomic features, and MRI. METHODS: The training and test datasets contained 122 patients with 1,570 images and 30 patients with 484 images, respectively. The radiomic features were extracted from enhancing tumors (ET), necrotic tumor cores (NCR), and the peritumoral edematous/infiltrated tissues (ED) using contrast-enhanced T1-weighted images (CE-T1WI) and T2-weighted images (T2WI)...

The bad metallic phase with resistivity above the Mott-Ioffe-Regel (MIR) limit, which appears also in cuprate superconductors, was recently understood by cold atom and computer simulations of the Hubbard model via charge susceptibility and charge diffusion constant. However, since reliable simulations can be typically done only at temperatures above the experimental temperatures, the question for cuprate superconductors is still open. This paper addresses this question by resorting to heat transport, which allows for the estimate of electronic diffusion and it further combines it with the resistivity to estimate the charge susceptibility...

Selective oxidation of sulfides to sulfoxides is of great significance in the synthesis of pharmaceuticals, desulfurization of fuels, and detoxification of sulfur mustard chemical warfare agents. Designing selective catalysts to achieve the efficient transformation of sulfides to sulfoxides is thus highly desired. Herein, we report three transition metal-complex-functionalized polyoxovanadates, [Zn2 (BPB)2 ][V4 O12 ]·0.5BPB·H2 O ( 1 ), [Ni(BPB)(H2 O)][V2 O6 ]·2H2 O ( 2 ), and [Co(HBPB)2 ][V4 O12 ] ( 3 ) (BPB = 1,4-bis(pyrid-4-yl)benzene)), and explore their applications for selective oxidation of sulfides using H2 O2 as an oxidant...

Owing to the high economic efficiency and energy density potential, manganese-based layer-structured oxides have attracted great interests as cathode materials for potassium ion batteries. In order to alleviate the continuous phase transition and K+ re-embedding from Jahn-Teller distortion, the [Mn-Co-Mo]O6 octahedra are introduced into P3-K0.45 MnO2 herein to optimize the local electron structure. Based on the experimental and computational results, the octahedral center metal molybdenum in [MoO6 ] octahedra proposes a smaller ionic radius and higher oxidation state to induce second-order JTE (pseudo-JTE) distortion in the adjacent [MnO6 ] octahedra...

In this article, density functional theory computations at the PBE0-D3/def2-TZVP level are reported to unveil the type of bonding between β-D-glucopyranose-silver ion (1:1) complex ([Ag(C6 H12 O6 )]+ ) and seven gas molecules, namely, H2 , C2 H2 , C2 H4 , CO, N2 , NO and O2 . Moreover, the relative preference of trapping among these molecules within the sight of Ag metal ion in the complex is explored. The nature of interaction of these small molecules with the [Ag(C6 H12 O6 )]+ ion is studied. Exergonic nature of binding is noted with the metal center for all the chosen small molecules except O2 ...

BACKGROUND: Glioblastoma (GBM) is notorious for the aggressive behaviors and easily results in chemo-resistance. Studies have shown that the use of herbal medicines as treatments for GBM as limited by the blood-brain barrier (BBB) and glioma stem cells. PURPOSE: The aim of this study was to investigate the relationship between GBM suppression and α-terpineol, the monoterpenoid alcohol derived from Eucalyptus glubulus and Pinus merkusii. STUDY DESIGN: Using serial in-vitro and in-vivo studies to confirm the mechanism of α-terpineol on down-regulating GBM development...

O6 -Methylguanine-DNA-methyltransferase (MGMT) is a demethylation protein that dynamically regulates the O6 -methylguanine modification (O6 MeG), and dysregulated MGMT is implicated in various malignant tumors. Herein, we integrate demethylation-activated DNAzyme with a single quantum dot nanosensor to sensitively detect MGMT in breast tissues. The presence of MGMT induces the demethylation of the O6 MeG-caged DNAzyme and the restoration of catalytic activity. The activated DNAzyme then specifically cleaves the ribonucleic acid site of hairpin DNA to expose toehold sequences...

Designing and synthesizing well-defined crystalline catalysts for the photocatalytic oxidative coupling of amines to imines remains a great challenge. In this work, a crystalline dumbbell-shaped titanium oxo cluster, [Ti10 O6 (Thdc)(Dmg)2 (i PrO)22 ] (Ti10, Thdc = 2,5-thiophenedicarboxylic acid, Dmg = dimethylglyoxime, i PrOH = isopropanol), was constructed through a facile one-pot solvothermal strategy and treated as a catalyst for the photocatalytic oxidative coupling of amines. In this structure, Thdc serves as the horizontal bar, while the {Ti5 Dmg} layers on each side act as the weight plates...

BACKGROUD: Glioblastoma multiforme (GBM) is among the most aggressive cancers, with current treatments limited in efficacy. A significant hurdle in the treatment of GBM is the resistance to the chemotherapeutic agent temozolomide (TMZ). The methylation status of the MGMT promoter has been implicated as a critical biomarker of response to TMZ. METHODS: To explore the mechanisms underlying resistance, we developed two TMZ-resistant GBM cell lines through a gradual increase in TMZ exposure...