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https://www.readbyqxmd.com/read/29667086/contrast-enhancement-predicting-survival-in-integrated-molecular-subtypes-of-diffuse-glioma-an-observational-cohort-study
#1
Johann-Martin Hempel, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Irina Gepfner-Tuma, Franziska Eckert, Ulrike Ernemann, Jens Schittenhelm
INTRODUCTION: To assess the predictive value of magnetic resonance imaging (MRI) gadolinium enhancement as a prognostic factor in the 2016 World Health Organization Classification of Tumors of the Central Nervous System integrated glioma groups. METHODS: Four-hundred fifty patients with histopathologically confirmed glioma were retrospectively assessed between 07/1997 and 06/2014 using gadolinium enhancement, survival, and relevant prognostic molecular data [isocitrate dehydrogenase (IDH); alpha-thalassemia/mental retardation syndrome X-linked (ATRX); chromosome 1p/19q loss of heterozygosity; and O6-methylguanine DNA methyltransferase (MGMT)]...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29658349/biodegradable-hybrid-structured-nanofibrous-membrane-supported-chemoprotective-gene-therapy-enhances-chemotherapy-tolerance-and-efficacy-in-malignant-glioma-rats
#2
Shih-Jung Liu, Tao-Chieh Yang, Shun-Tai Yang, Ying-Chun Chen, Yuan-Yun Tseng
Chemotherapy is ineffective for treating malignant glioma (MG) because of the low therapeutic levels of pharmaceuticals in tumour tissues and the well-known tumour resistance. The resistance to alkylators is modulated by the DNA repair protein O6 -alkylguanine-DNA alkyltransferase (AGT). O6 -benzylguanine (O6 -BG) can irreversibly inactivate AGT by competing with O6 -methylguanine and has been confirmed to increase the therapeutic activity of alkylators. We developed hybrid-structured poly[(d,l)-lactide-co-glycolide] nanofibrous membranes (HSNMs) that enable the sequential and sustained release of O6 -BG and two alkylators (carmustine and temozolomide [TMZ])...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29644711/outlining-involvement-of-stem-cell-program-in-regulation-of-o6-methylguanine-dna-methyltransferase-and-development-of-temozolomide-resistance-in-glioblastoma-an-editorial-highlight-for-transcriptional-control-of-o-6-methylguanine-dna-methyltransferase-expression
#3
EDITORIAL
Anastasia Chumakova, Justin D Lathia
Glioblastoma is a malignant brain tumor that inevitably develops resistance to standard of care drug temozolomide (TMZ) due to a population of cells called cancer stem cells (CSCs). These cells utilize progenitor cell signaling programs and develop robust DNA repair machinery. In this editorial highlight we focus on stem cell regulation of TMZ resistance and discuss findings of Happold et al. () that outline direct transcriptional regulation of DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) in glioblastoma CSCs through NFkB activation...
March 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29620034/supramolecular-hydrogen-bonding-patterns-in-salts-of-the-antifolate-drugs-trimethoprim-and-pyrimethamine
#4
Robert Swinton Darious, Packianathan Thomas Muthiah, Franc Perdih
Nine salts of the antifolate drugs trimethoprim and pyrimethamine, namely, trimethoprimium [or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidin-1-ium] 2,5-dichlorothiophene-3-carboxylate monohydrate (TMPDCTPC, 1:1), C14 H19 N4 O3 + ·C5 HCl2 O2 S- , (I), trimethoprimium 3-bromothiophene-2-carboxylate monohydrate, (TMPBTPC, 1:1:1), C14 H19 N4 O3 + ·C5 H2 BrO2 S- ·H2 O, (II), trimethoprimium 3-chlorothiophene-2-carboxylate monohydrate (TMPCTPC, 1:1:1), C14 H19 N4 O3 + ·C5 H2 ClO2 S- ·H2 O, (III), trimethoprimium 5-methylthiophene-2-carboxylate monohydrate (TMPMTPC, 1:1:1), C14 H19 N4 O3 + ·C6 H5 O2 S- ·H2 O, (IV), trimethoprimium anthracene-9-carboxylate sesquihydrate (TMPAC, 2:2:3), C14 H19 N4 O3 + ·C15 H9 O2 - ·1...
April 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29619003/the-clinical-significance-of-o-6-methylguanine-dna-methyltransferase-promoter-methylation-status-in-adult-patients-with-glioblastoma-a-meta-analysis
#5
Yu-Hang Zhao, Ze-Fen Wang, Chang-Jun Cao, Hong Weng, Cheng-Shi Xu, Kai Li, Jie-Li Li, Jing Lan, Xian-Tao Zeng, Zhi-Qiang Li
Background and objective: Promoter status of O6 -methylguanine-DNA methyltransferase ( MGMT ) has been widely established as a clinically relevant factor in glioblastoma (GBM) patients. However, in addition to varied therapy schedule, the prognosis of GBM patients is also affected by variations of age, race, primary or recurrent tumor. This study comprehensively investigated the association between MGMT promoter status and prognosis in overall GBM patients and in different GBM subtype including new diagnosed patients, recurrent patients and elderly patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29618055/malignancy-index-using-intraoperative-flow-cytometry-is-a-valuable-prognostic-factor-for-glioblastoma-treated-with-radiotherapy-and-concomitant-temozolomide
#6
Taiichi Saito, Yoshihiro Muragaki, Takahiro Shioyama, Takashi Komori, Takashi Maruyama, Masayuki Nitta, Takayuki Yasuda, Junji Hosono, Saori Okamoto, Takakazu Kawamata
BACKGROUND: Intraoperative prediction of radiochemosensitivity is desirable for improving the clinical management of glioblastoma (GBM) patients. We have previously developed an original technique for intraoperative flow cytometry (iFC) and defined a malignancy index (MI). OBJECTIVE: To determine whether MI correlates with prognosis in GBM patients who underwent the standard treatment protocol of radiotherapy and temozolomide administration. METHODS: The current study included 102 patients with GBM that had been newly diagnosed from 2010 to 2015 who underwent our iFC analysis and received the standard treatment protocol...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29617848/surgery-for-glioblastoma-in-light-of-molecular-markers-impact-of-resection-and-mgmt-promoter-methylation-in-newly-diagnosed-idh-1-wild-type-glioblastomas
#7
Florian Gessler, Joshua D Bernstock, Anne Braczynski, Stephanie Lescher, Peter Baumgarten, Patrick N Harter, Michel Mittelbronn, Tianxia Wu, Volker Seifert, Christian Senft
BACKGROUND: Previous studies addressing the influence of surgery on the outcome of patients with glioblastomas (GBM) have not addressed molecular markers. The value of surgery versus the tumor's major biological markers remains unclear. OBJECTIVE: We investigate the extent of resection as a prognosticator for patients with newly diagnosed primary GBM with the incorporation of molecular diagnostics as per the updated WHO 2016 diagnostic criteria for GBM. METHODS: Patients with newly diagnosed GBM who underwent resection were prospectively included within a database...
March 27, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29616996/crystal-structure-phase-transition-and-structural-deformations-in-iron-borate-y-0-95-bi-0-05-fe-3-bo-3-4-in-the-temperature-range-90-500-k
#8
Ekaterina S Smirnova, Olga A Alekseeva, Alexander P Dudka, Vladimir V Artemov, Yan V Zubavichus, Irina A Gudim, Leonard N Bezmaterhykh, Kirill V Frolov, Igor S Lyubutin
An accurate X-ray diffraction study of (Y0.95 Bi0.05 )Fe3 (BO3 )4 single crystals in the temperature range 90-500 K was performed on a laboratory diffractometer and used synchrotron radiation. It was established that the crystal undergoes a diffuse structural phase transition in the temperature range 350-380 K. The complexity of localization of such a transition over temperature was overcome by means of special analysis of systematic extinction reflections by symmetry. The transition temperature can be considered to be Tstr ≃ 370 K...
April 1, 2018: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/29616805/reduction-of-werner-syndrome-protein-enhances-g-c-a-t-transition-by-o-6-methylguanine-in-human-cells
#9
Tetsuya Suzuki, Yoshie Kuramoto, Hiroyuki Kamiya
O6-Methylguanine (O6-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-related human DNA helicase. The effects of WRN reduction on O6-MeG-caused mutagenesis were assessed by an siRNA-mediated knockdown in human U2OS cells, using a shuttle plasmid with a single O6-MeG base in the supF gene. The plasmid DNA was replicated in the cells, isolated, and electroporated into an Escherichia coli indicator strain. The lowered amount of WRN increased the frequency of mutations induced by O6-MeG, mainly G:C-->A:T substitution...
April 4, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29608058/structural-incorporation-of-manganese-into-goethite-and-its-enhancement-of-pb-ii-adsorption
#10
Huan Liu, Xiancai Lu, Meng Li, Lijuan Zhang, Chao Pan, Juan Li, Rui Zhang, Wanli Xiang
Natural goethite (a-FeOOH) commonly accommodates various metal elements by substituting for Fe, which greatly alters the surface reactivity of goethite. This study discloses the enhancement of Mn-substitution for the Pb2+ adsorption capacity of goethite. The incorporated Mn in the synthesized goethite presents as Mn(III) and causes a slight decrease in the a and c of the unit cell parameters and an observable increase in the b direction due to the Jahn-Teller effect of the Mn(III)O6 octahedra. With the Mn content increasing, the particle size decreases gradually, and the surface clearly becomes roughened...
April 2, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29606808/clinical-and-prognostic-significance-of-o-6-methylguanine-dna-methyltransferase-promoter-methylation-in-patients-with-melanoma-a-systematic-meta-analysis
#11
REVIEW
Fang Qi, Zhiqi Yin, Guangping Wang, Sanwu Zeng
Tumor suppressor gene O6 -methylguanine-DNA methyltransferase ( MGMT ) promoter methylation has been reported in melanoma. However, the clinical and prognostic significance of MGMT promoter methylation in patients with melanoma remained to be determined. A systematic search was performed to identify eligible papers published. The overall odds ratios (ORs) or hazard ratios and their 95% confidence intervals were calculated. Final 12 eligible publications involving Caucasian population were performed in this study, including 1,071 metastatic melanoma patients, 154 primary melanoma patients, and 211 normal controls...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29596824/crystal-structure-of-e-coli-zint-with-one-zinc-binding-mode-and-complexed-with-citrate
#12
Jinli Chen, Lulu Wang, Fei Shang, Yuesheng Dong, Nam-Chul Ha, Ki Hyun Nam, Chunshan Quan, Yongbin Xu
The ZnuABC ATP-binding cassette transporter found in gram-negative bacteria has been implicated in ensuring adequate zinc import into Zn(II)-poor environments. ZinT is an essential component of ZnuABC and contributes to metal transport by transferring metals to ZnuA, which delivers them to ZnuB in periplasmic zinc recruitment. Although several structures of E. coli ZinT have been reported, its zinc-binding sites and oligomeric state have not been clearly identified. Here, we report the crystal structure of E...
March 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29589963/serotyping-and-genotyping-characterization-of-pathogenic-escherichia-coli-strains-in-kimchi-and-determination-of-their-kinetic-behavior-in-cabbage-kimchi-during-fermentation
#13
Yukyung Choi, Soomin Lee, Hyun Jung Kim, Heeyoung Lee, Sejeong Kim, Jeeyeon Lee, Jimyeong Ha, Hyemin Oh, Jang Won Yoon, Yohan Yoon, Kyoung-Hee Choi
This study determined the serotyping and genotyping properties of Escherichia coli strains isolated from kimchi and various raw vegetables used for kimchi preparation. In addition, the kinetic behavior of E. coli strains in kimchi during fermentation was also determined using a predictive microbiological model. The study results revealed that E. coli isolated from napa cabbage (3.3%; 1/30) was enterohemorrhagic E. coli (O6:H34), and eight typical colonies isolated from kimchi (15%; 6/40) were enteropathogenic E...
March 28, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29589213/effects-of-some-growth-factors-and-cytokines-on-the-expression-of-the-repair-enzyme-mgmt-and-protein-marp-in-human-cells-in-vitro-effect-of-some-growth-factors-and-cytokines
#14
Kateryna Kotsarenko, Valentyna Lylo, Tetiana Ruban, Larysa Macewicz, Lyubov Lukash
The inducible repair enzyme O6 -methylguanine-DNA methyltransferase (MGMT) eliminates O6 -methylguanine adducts in DNA and protects the cells from damaging effects of alkylating agents. We have found that anti-MGMT antibodies recognize both the MGMT protein with a mol. weight ~ 24 kDa and a protein with a mol. weight ~ 48 kDa, which was named MARP (anti-methyltransferase antibody recognizable protein). A number of growth factors and cytokines were shown to regulate the expression of MGMT and MARP proteins...
March 27, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29572492/radiomic-mri-signature-reveals-three-distinct-subtypes-of-glioblastoma-with-different-clinical-and-molecular-characteristics-offering-prognostic-value-beyond-idh1
#15
Saima Rathore, Hamed Akbari, Martin Rozycki, Kalil G Abdullah, MacLean P Nasrallah, Zev A Binder, Ramana V Davuluri, Robert A Lustig, Nadia Dahmane, Michel Bilello, Donald M O'Rourke, Christos Davatzikos
The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning. Non-invasive in vivo characterization of this heterogeneity using imaging could assist in understanding disease subtypes, as well as in risk-stratification and treatment planning of glioblastoma. The current study leveraged advanced imaging analytics and radiomic approaches applied to multi-parametric MRI of de novo glioblastoma patients (n = 208 discovery, n = 53 replication), and discovered three distinct and reproducible imaging subtypes of glioblastoma, with differential clinical outcome and underlying molecular characteristics, including isocitrate dehydrogenase-1 (IDH1), O6 -methylguanine-DNA methyltransferase, epidermal growth factor receptor variant III (EGFRvIII), and transcriptomic subtype composition...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29564594/multiregional-radiomics-features-from-multiparametric-mri-for-prediction-of-mgmt-methylation-status-in-glioblastoma-multiforme-a-multicentre-study
#16
Zhi-Cheng Li, Hongmin Bai, Qiuchang Sun, Qihua Li, Lei Liu, Yan Zou, Yinsheng Chen, Chaofeng Liang, Hairong Zheng
OBJECTIVES: To build a reliable radiomics model from multiregional and multiparametric magnetic resonance imaging (MRI) for pretreatment prediction of O6 -methylguanine-DNA methyltransferase (MGMT) promotor methylation status in glioblastoma multiforme (GBM). METHODS: In this retrospective multicentre study, 1,705 multiregional radiomics features were automatically extracted from multiparametric MRI. A radiomics model with a minimal set of all-relevant features and a radiomics model with univariately-predictive and non-redundant features were built for MGMT methylation prediction from a primary cohort (133 patients) and tested on an independent validation cohort (60 patients)...
March 21, 2018: European Radiology
https://www.readbyqxmd.com/read/29540711/spin-liquid-like-state-in-a-spin-1-2-square-lattice-antiferromagnet-perovskite-induced-by-d-10-d-0-cation-mixing
#17
O Mustonen, S Vasala, E Sadrollahi, K P Schmidt, C Baines, H C Walker, I Terasaki, F J Litterst, E Baggio-Saitovitch, M Karppinen
A quantum spin liquid state has long been predicted to arise in spin-1/2 Heisenberg square-lattice antiferromagnets at the boundary region between Néel (nearest-neighbor interaction dominates) and columnar (next-nearest-neighbor interaction dominates) antiferromagnetic order. However, there are no known compounds in this region. Here we use d10 -d0 cation mixing to tune the magnetic interactions on the square lattice while simultaneously introducing disorder. We find spin-liquid-like behavior in the double perovskite Sr2 Cu(Te0...
March 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29536064/achieving-high-capacity-hybrid-cathode-fef-3-li-2-c-6-o-6-rgo-based-on-morphology-control-synthesis-and-interface-engineering
#18
Chengyi Lu, Chen Dong, Haitao Wu, Dan Ni, Wang Sun, Zhenhua Wang, Kening Sun
The common high-capacity cathode Li2 C6 O6 shows poor cycling performance because of its dissolution in electrolytes. Using morphology control, spherical Li2 C6 O6 was prepared, and then combined with reduced graphene oxide and modified with an FeF3 coating. This interface engineering inhibited the dissolution of Li2 C6 O6 , and also enhanced its cycling and rate performance.
March 14, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29534033/structure-function-analysis-of-cotton-based-peptide-cellulose-conjugates-spatiotemporal-kinetic-assessment-of-protease-aerogels-compared-to-nanocrystalline-and-paper-cellulose
#19
J Vincent Edwards, Krystal Fontenot, Falk Liebner, Nicole Doyle Nee Pircher, Alfred D French, Brian D Condon
Nanocellulose has high specific surface area, hydration properties, and ease of derivatization to prepare protease sensors. A Human Neutrophil Elastase sensor designed with a nanocellulose aerogel transducer surface derived from cotton is compared with cotton filter paper, and nanocrystalline cellulose versions of the sensor. X-ray crystallography was employed along with Michaelis-Menten enzyme kinetics, and circular dichroism to contrast the structure/function relations of the peptide-cellulose conjugate conformation to enzyme/substrate binding and turnover rates...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29530602/drug-induced-xenogenization-of-tumors-a-possible-role-in-the-immune-control-of-malignant-cell-growth-in-the-brain
#20
REVIEW
Ornella Franzese, Fiorenzo Battaini, Grazia Graziani, Lucio Tentori, Maria Luisa Barbaccia, Angelo Aquino, Mario Roselli, Maria Pia Fuggetta, Enzo Bonmassar, Francesco Torino
In recent years, immune checkpoint inhibitors (ICpI) have provided the ground to bring tumor immunity back to life thanks to their capacity to afford a real clinical benefit in terms of patient's survival. Essential to ICpI success is the presence of tumor-associated neoantigens generated by non-synonymous mutations, since a direct relationship between mutation load of malignant cells and susceptibility to ICpI has been confidently established. However, it has been also suggested that high intratumor heterogeneity (ITH) associated with subclonal neoantigens could not elicit adequate immune responses...
March 9, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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