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https://www.readbyqxmd.com/read/27900831/cooperation-of-three-chromophores-generates-the-water-resistant-nitrate-nonlinear-optical-material-bi3-teo6-oh-no3-2
#1
Sangen Zhao, Yi Yang, Yaoguo Shen, Bingqing Zhao, Lina Li, Chengmin Ji, Zhenyue Wu, Daqiang Yuan, Zheshuai Lin, Maochun Hong, Junhua Luo
Nitrates have long been ignored for practical uses as nonlinear optical (NLO) materials because they are usually very easy to dissolve in water; despite this, the π-conjugated [NO3 ](-) is among the most desirable NLO-active structural units. The cooperation of three structural chromophores, namely, Bi3 O6 OH short chains with 6s(2) lone pair electrons, distorted TeO6 octahedra with d(10) electrons, and π-conjugated [NO3 ](-) triangles, generates a new nitrate NLO material, Bi3 TeO6 OH(NO3 )2 , which exhibits an enhanced phase-matchable NLO response of three times that of KH2 PO4 (3×KH2 PO4 ), exceeding those of most nitrate NLO materials...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27887040/in-vitro-assessment-of-non-irritant-microemulsified-voriconazole-hydrogel-system
#2
Prasanna Raju Y, Hyndavi N, Harini Chowdary V, Rajesh S Nair, Jamal Basha D, Tejeswari N
Research was aimed on microemulsion-based hydrogel for voriconazole. Oleic acid and isopropyl myristate as lipid phases; tween 20: tween 80 as surfactants and PEG600 as cosurfactant were selected to formulate voriconazole microemulsions. The promising microemulsions in terms of zeta potential, pH, viscosity, and drug release were selected and developed into hydrogels using carbopol 934. Resulting microemulsion-based hydrogel (MBH) of voriconazole were evaluated for in vitro diffusion and ex vivo permeation...
November 25, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27862443/direct-synthesis-of-two-inorganic-catalysts-on-carbon-fibres-for-the-electrocatalytic-oxidation-of-water
#3
Henrik Svengren, Kjell Jansson, Jekabs Grins, Wei Wan, Natallia Torapava, Mats Johnsson
Two electrodes for anodic water oxidation made by direct synthesis of inorganic catalysts onto conductive carbon fibre sheets are evaluated. As catalysts two Co- and Sb-containing phases were tested, that is, Co3 Sb4 O6 F6 and the new compound CoSbO4 . The compounds express large differences in their morphology: CoSbO4 grows as thin needles whereas Co3 Sb4 O6 F6 grows as larger facetted crystals. Despite the smaller surface area the latter compound shows a better catalytic performance. When the compound Co3 Sb4 O6 F6 was used it gave a low increase of +0...
November 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27848899/computational-modeling-approach-in-probing-effects-of-cytosine-methylation-on-the-transcription-factor-binding-to-dna
#4
John Tenayuca, Kimberley Cousins, Shumei Yang, Lubo Zhang
Cytosine methylation at CpG dinucleotides is a chief mechanism in epigenetic modification of gene expression patterns. Previous studies demonstrated that increased CpG methylation of Sp1 sites at -268 and -346 of protein kinase C  promoter repressed the gene expression. The present study investigated the impact of CpG methylation on the Sp1 binding via molecular modeling and electrophoretic mobility shift assay. Each of the Sp1 sites contain two CpGs. Methylation of either CpG lowered the binding affinity of Sp1, whereas methylation of both CpGs produced a greater decrease in the binding affinity...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27795239/draft-genome-sequence-of-an-escherichia-coli-strain-isolated-from-a-gallus-gallus-broiler-producing-the-novel-ctx-m-166-variant
#5
Vera Manageiro, Lurdes Clemente, Sílvia Duarte, Luís Vieira, Manuela Caniça
We report here the draft genome sequence of the CTX-M-166-harboring O6:H16 sequence type 48 (ST48)-fimH34 Escherichia coli strain recovered from a Gallus gallus broiler. Sequence analyses revealed the presence of an IncI1/ST103-ISEcp1-blaCTX-M-166-orf477 plasmid region and of diverse antibiotic resistance and virulence-acquired genes.
October 6, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27793847/dna-repair-capacity-in-multiple-pathways-predicts-chemoresistance-in-glioblastoma-multiforme
#6
Zachary D Nagel, Gaspar J Kitange, Shiv K Gupta, Brian A Joughin, Isaac A Chaim, Patrizia Mazzucato, Douglas A Lauffenburger, Jann N Sarkaria, Leona D Samson
Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC) measurements in cancer cells could be used to identify patients most likely to respond to treatment. However, the limitations of available technologies have so far precluded adoption of this approach in the clinic. We recently developed fluorescence-based multiplexed host cell reactivation (FM-HCR) assays to measure DRC in multiple pathways. Here we apply a mathematical model that uses DRC in multiple pathways to predict cellular resistance to killing by DNA-damaging agents...
October 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27785051/relationships-between-mgmt-promoter-methylation-and-gastric-cancer-a-meta-analysis
#7
Dan Yu, Tao Cao, Ya-Di Han, Fu-Sheng Huang
A DNA repair enzyme, O6-methylguanine-DNA methyltransferase (MGMT), plays an important role in the development of gastric cancers. However, the role of MGMT promoter methylation in the occurrence of gastric cancer and its relationships with clinicopathologic characteristics has not been fully clarified. Thus, we performed a meta-analysis to evaluate the associations between MGMT promoter methylation and gastric cancer. Electronic databases, including PubMed and Web of Science, were used to systematically search related clinical studies published in English until April 1, 2016...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27776146/a-root-colonizing-pseudomonad-lessens-stress-responses-in-wheat-imposed-by-cuo-nanoparticles
#8
Melanie Wright, Joshua Adams, Kwang Yang, Paul McManus, Astrid Jacobson, Aniket Gade, Joan McLean, David Britt, Anne Anderson
Nanoparticle (NPs) containing essential metals are being considered in formulations of fertilizers to boost plant nutrition in soils with low metal bioavailability. This paper addresses whether colonization of wheat roots by the bacterium, Pseudomonas chlororaphis O6 (PcO6), protected roots from the reduced elongation caused by CuO NPs. There was a trend for slightly elongated roots when seedlings with roots colonized by PcO6 were grown with CuO NPs; the density of bacterial cells on the root surface was not altered by the NPs...
2016: PloS One
https://www.readbyqxmd.com/read/27775348/synthesis-of-d-galactosamine-and-d-allosamine-derivatives-via-a-microwave-assisted-preparation-of-1-6-anhydroglucosamine
#9
Vijay M Dhurandhare, Yuh-Sheng Wen, Sachin D Gawande, Pin-Hsuan Liao, Cheng-Chung Wang
We report a microwave-assisted intramolecular anomeric protection (iMAP) of glucosamine, which facilitates concise transformation of 1,6-anhydroglucosamine into 1,6-anhydrogalactosamine and 1,6-anhydroallosamine. The iMAP simultaneously obviates both the O1 and O6 protection, and the differentiation between O3 and O4 can be well-controlled by the N2 functionality because of the hydrogen bonding between N2 and O4. Epimerization of O4 afforded the galactosamine derivative and that of O3 yielded allosamine.
October 24, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27775192/dual-sensitized-luminescent-europium-%C3%AE-%C3%AE-%C3%AE-and-terbium-%C3%AE-%C3%AE-%C3%AE-complexes-as-bioimaging-and-light-responsive-therapeutic-agents
#10
Srikanth Dasari, Swati Singh, Sri Sivakumar, Ashis K Patra
Dual-photosensitized stable Eu(ΙΙΙ) and Tb(ΙΙΙ) complexes, namely [Eu(dpq)(tfnb)3 ] (1) and [Tb(dpq)(tfnb)3 ] (2), in which dpq=dipyrido[3,2-d:2',3'-f]quinoxaline and Htfnb=4,4,4-trifluoro-1-(2-napthyl)-1,3-butanedione, were designed as bioimaging and light-responsive therapeutic agents. Their X-ray structures, photophysical properties, biological interactions, photoinduced DNA damage, photocytotoxicity, and cellular uptake properties were studied. Discrete mononuclear complexes adopt an eight-coordinated {LnN2 O6 } distorted square antiprism geometry with bidentate N,N-donor dpq and O,O-donor tfnb ligands...
November 21, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27768841/o6-2-deoxyguanosine-butylene-o6-2-deoxyguanosine-dna-interstrand-cross-links-are-replication-blocking-and-mutagenic-dna-lesions
#11
Wenyan Xu, Daniel Kool, Derek K O'Flaherty, Ashley Keating, Lauralicia Sacre, Martin Egli, Anne Marietta Noronha, Christopher James Wilds, Linlin Zhao
DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and for the development of effective chemotherapies. Previous research has focused on ICLs cross-linked with the N7 and N2 atoms of guanine as well as those formed at the N6 atom of adenine; however, little is known about the mutagenicity of O6-dG-derived ICLs...
October 21, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27741574/dna-polymerase-%C3%AE-rapidly-bypasses-o-6-methyl-dg-but-not-o-6-4-3-pyridyl-4-oxobutyl-dg-and-o-2-alkyl-dts
#12
Prakasha Gowda, Thomas E Spratt
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco carcinogen that forms mutagenic DNA adducts including O(6)-methyl-2'-deoxyguanosine (O(6)-Me-dG), O(6)-[4-(3-pyridyl)-4-oxobut-1-yl]-dG (O6-POB-dG), O(2)-methylthymidine (O(2)-Me-dT), and O(2)-POB-dT. We evaluated the ability of human DNA polymerase ν to bypass this damage to evaluate the structural constraints on substrates for pol ν and to evaluate if there is kinetic evidence suggesting the in vivo activity of pol ν on tobacco-induced DNA damage...
October 14, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27728767/dihydromethysticin-dhm-blocks-tobacco-carcinogen-4-methylnitrosamino-1-3-pyridyl-1-butanone-nnk-induced-o6-methylguanine-independent-of-aryl-hydrocarbon-receptor-ahr-in-c57bl-6-female-mice
#13
Sreekanth C Narayanapillai, Shang-Hsuan Lin, Pablo Leitzman, Pramod Upadhyaya, Carolyn J Baglole, Chengguo Xing
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a key carcinogen responsible for tobacco smoke-induced lung carcinogenesis. Among DNA damages caused by NNK and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), O6-methylguanine (O6-mG) is likely the most carcinogenic in A/J mice. Results of our previous studies showed that O6-mG and other NNAL-derived DNA damages were preferentially reduced in the lung of female A/J mice upon the dietary treatment with dihydromethysticin (DHM), a promising lung cancer chemopreventive agent from kava...
October 11, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27721311/gamma-knife-radiosurgery-in-recurrent-glioblastoma
#14
Josa M Frischer, Christine Marosi, Adelheid Woehrer, Johannes A Hainfellner, Karin Ute Dieckmann, Helmut Eiter, Wei-Te Wang, Ammar Mallouhi, Adolf Ertl, Engelbert Knosp, Martin Filipits, Klaus Kitz, Brigitte Gatterbauer
BACKGROUND: We evaluated Gamma Knife radiosurgery (GKRS) as a treatment option for patients with recurrent glioblastoma. PATIENTS AND METHODS: 42 patients with histopathologically diagnosed recurrent grade IV tumor were treated with GKRS. All patients had undergone standard multimodal first-line treatment. The average time from diagnosis to GKRS was 17.0 months. The median target volume was 5.1 cm3. The median margin dose was 10 Gy and the median central dose 20 Gy...
October 8, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27704222/distinct-differences-in-metal-ion-specificity-of-rna-and-dna-g-quadruplexes
#15
Helena Guiset Miserachs, Daniela Donghi, Richard Börner, Silke Johannsen, Roland K O Sigel
RNA G-quadruplexes, as their well-studied DNA analogs, require the presence of cations to fold and remain stable. This is the first comprehensive study on the interaction of RNA quadruplexes with metal ions. We investigated the formation and stability of two highly conserved and biologically relevant RNA quadruplex-forming sequences (24nt-TERRA and 18nt-NRAS) in the presence of several monovalent and divalent metal ions, namely Li(+), Na(+), K(+), Rb(+), Cs(+), NH4(+), Mg(2+), Ca(2+), Sr(2+), and Ba(2+). Circular dichroism was used to probe the influence of these metal ions on the folded fraction of the parallel G-quadruplexes, and UV thermal melting experiments allowed to assess the relative stability of the structures in each cationic condition...
October 4, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/27699961/pheophytin-a-isolated-from-the-seagrass-syringodium-isoetifolium-plausibly-blocks-umuc-proteins-of-select-bacterial-pathogens-in-silico
#16
C V Sathyanathan, B Jyothirmayi, L R Sundaram, P A Abhinand, R Eswaramoorthy, K M E Gnanambal
AIMS: This investigation is designed to evaluate the antibacterial efficiency of the noodle grass Syringodium isoetifolium, which is commonly found in the Indian coastal waters. Also, this study characterizes the active compound and predicts the mode of action in silico. METHODS AND RESULTS: Human pathogenic bacteria were treated with crude metabolites of S. isoetifolium. The potent fraction b was analysed by UV/VIS, Spectroscopy RP-HPLC, FT-IR, ESI-Mass and (1) H and (13) C NMRs and determined to be a hydrate of pheophytin a (C55 H74 N4 O6 )...
December 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27694439/mechanisms-of-insertion-of-dctp-and-dttp-opposite-the-dna-lesion-o6-methyl-2-deoxyguanosine-by-human-dna-polymerase-%C3%AE
#17
Amitraj Patra, Qianqian Zhang, F Peter Guengerich, Martin Egli
O(6)-Methyl-2'-deoxyguanosine (O(6)-MeG) is a ubiquitous DNA lesion, formed not only by xenobiotic carcinogens but also by the endogenous methylating agent S-adenosylmethionine. It can introduce mutations during DNA replication, with different DNA polymerases displaying different ratios of correct or incorrect incorporation opposite this nucleoside. Of the "translesion" Y-family human DNA polymerases (hpols), hpol η is most efficient in incorporating equal numbers of correct and incorrect C and T bases. However, the mechanistic basis for this specific yet indiscriminate activity is not known...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27693246/permeability-surface-area-product-using-perfusion-ct-is-a-valuable-prognostic-factor-in-glioblastomas-treated-with-radiotherapy-plus-concomitant-and-adjuvant-temozolomide
#18
Taiichi Saito, Kazuhiko Sugiyama, Fusao Ikawa, Fumiyuki Yamasaki, Minoru Ishifuro, Takeshi Takayasu, Ryo Nosaka, Yoshihiro Muragaki, Takakazu Kawamata, Kaoru Kurisu
OBJECTIVE: The current standard treatment protocol for patients with newly diagnosed glioblastoma (GBM) includes surgery, radiotherapy, and concomitant and adjuvant temozolomide (TMZ). We hypothesized that the permeability surface area product (PS) from a perfusion CT (PCT) study is associated with sensitivity to TMZ. The aim of this study was to determine whether PS values were correlated with prognosis of GBM patients who received the standard treatment protocol. METHODS: This study included 36 patients with GBM that were newly diagnosed between October 2005 and September 2014 and who underwent preoperative PCT study and the standard treatment protocol...
September 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27689346/homogeneous-cobalt-vanadium-complexes-as-precursors-for-functionalized-mixed-oxides-in-visible-light-driven-water-oxidation
#19
Mariia V Pavliuk, Edgar Mijangos, Valeriya G Makhankova, Vladimir N Kokozay, Sonja Pullen, Jia Liu, Jiefang Zhu, Stenbjörn Styring, Anders Thapper
The heterometallic complexes (NH4 )2 [Co(H2 O)6 ]2 [V10 O28 ]⋅4 H2 O (1) and (NH4 )2 [Co(H2 O)5 (β-HAla)]2 [V10 O28 ]⋅4 H2 O (2) have been synthesized and used for the preparation of mixed oxides as catalysts for water oxidation. Thermal decomposition of 1 and 2 at relatively low temperatures (<500 °C) leads to the formation of the solid mixed oxides CoV2 O6 /V2 O5 (3) and Co2 V2 O7 /V2 O5 (4). The complexes (1, 2) and heterogeneous materials (3, 4) act as catalysts for photoinduced water oxidation...
September 30, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27680715/ba3-cr0-97-1-te0-03-1-2teo9-in-search-of-jahn-teller-distorted-cr-ii-oxide
#20
Man-Rong Li, Zheng Deng, Saul H Lapidus, Peter W Stephens, Carlo U Segre, Mark Croft, Robert Paria Sena, Joke Hadermann, David Walker, Martha Greenblatt
A novel 6H-type hexagonal perovskite Ba3(Cr0.97(1)Te0.03(1))2TeO9 was prepared at high pressure (6 GPa) and temperature (1773 K). Both transmission electron microscopy and synchrotron powder X-ray diffraction data demonstrate that Ba3(Cr0.97(1)Te0.03(1))2TeO9 crystallizes in P63/mmc with face-shared (Cr0.97(1)Te0.03(1))O6 octahedral pairs interconnected with TeO6 octahedra via corner-sharing. Structure analysis shows a mixed Cr(2+)/Cr(3+) valence state with ∼10% Cr(2+). The existence of Cr(2+) in Ba3(Cr(2+)0...
October 17, 2016: Inorganic Chemistry
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