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JOURNAL ARTICLE
Amanda L Vinson, Nicholas W Vandenberg, Mohamed E Awad, Cory L Christiansen, Jason W Stoneback, Brecca M M Gaffney
Individuals with unilateral transtibial amputation (TTA) using socket prostheses demonstrate asymmetric joint biomechanics during walking, which increases the risk of secondary comorbidities (e.g., low back pain (LBP), osteoarthritis (OA)). Bone-anchored limbs are an alternative to socket prostheses, yet it remains unknown how they influence multi-joint loading. Our objective was to determine the influence of bone-anchored limb use on multi-joint biomechanics during walking. Motion capture data (kinematics, ground reaction forces) were collected during overground walking from ten participants with unilateral TTA prior to (using socket prostheses) and 12-months after bone-anchored limb implantation...
April 15, 2024: Journal of Biomechanics
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JOURNAL ARTICLE
Zongsheng He, Arne S IJpma, Dianne Vreeken, Daphne Heijsman, Karen Rosier, Hence J M Verhagen, Jorg de Bruin, Hennie T Brüggenwirth, Jolien W Roos-Hesselink, Jos A Bekkers, Danny Huylebroeck, Heleen van Beusekom, John W M Creemers, Danielle Majoor-Krakauer
AIM: Aortic aneurysms (AA) frequently involve dysregulation of transforming growth factor β (TGF-β)-signaling in the aorta. Here, FURIN was tested as aneurysm predisposition gene given its role as proprotein convertase in pro-TGF-β maturation. METHODS AND RESULTS: Rare FURIN variants were detected by whole-exome sequencing of 781 unrelated aortic aneurysm patients and affected relatives. Thirteen rare heterozygous FURIN variants occurred in 3.7% (29) unrelated index AA patients, of which 72% had multiple aneurysms or a dissection...
April 18, 2024: Cardiovascular Research
#3
JOURNAL ARTICLE
Fabrício Emanuel Soares de Oliveira, Samuel Trezena, Daniella Reis Barbosa Martelli, Maria Christina L Oliveira, Enrico A Colosimo, Hercílio Martelli, Eduardo Araújo Oliveira
OBJECTIVE: To describe the clinical outcomes and risk factors of death related to mental disorders in a cohort of Brazilian hospitalized patients with COVID-19. METHODS: This retrospective cohort study utilized the Brazilian database SIVEP-Gripe to analyze patients aged ≥18 years who had been hospitalized with COVID-19 between 2020 and 2022. The exposure of interest were mental disorders (anxiety, depression, schizophrenia, and bipolar disorder), identified through self-reported fields...
April 18, 2024: Revista Brasileira de Psiquiatria
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JOURNAL ARTICLE
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
Oncogenic KRAS impairs anti-tumor immune responses. As effective strategies to combine KRAS inhibitors and immunotherapies have so far proven elusive, a better understanding of how oncogenic KRAS drives immune evasion is needed to identify approaches that could sensitize KRAS-mutant lung cancer to immunotherapy. In vivo CRISPR-Cas9 screening in an immunogenic murine lung cancer model identified mechanisms by which oncogenic KRAS promotes immune evasion, most notably via upregulation of immunosuppressive cyclooxygenase-2 (COX-2) in cancer cells...
April 18, 2024: Cancer Research
#5
JOURNAL ARTICLE
Gejun Tong, Jingzhao Shen, Jianyong Pang, Haotian Shi, Jinkun Huang
The new thermal insulating shotcrete is of great significance for the management of thermal damage in deep mines, and its own strength has a greater impact on the roadway insulation and safe production, so it is very necessary to study the shear strength of the new thermal insulating shotcrete under the influence of the deep hot and humid environment and the stress of mining. For the heat-insulating shotcrete, firstly, we carried out the concrete variable angle shear test under different loading rates, which concluded that the shear rate and peak shear stress showed a trend of increasing and then decreasing; as the angle increases, the different rates have a greater impact on the peak shear stress of the specimen...
2024: PloS One
#6
JOURNAL ARTICLE
Avian White, Guy Iverson, LaNika Wright, John T Fallon, Kimberly P Briley, Changhong Yin, Weihua Huang, Charles Humphrey
The COVID-19 outbreak led governmental officials to close many businesses and schools, including colleges and universities. Thus, the ability to resume normal campus operation required adoption of safety measures to monitor and respond to COVID-19. The objective of this study was to determine the efficacy of wastewater-based epidemiology as a surveillance method in monitoring COVID-19 on a college campus. The use of wastewater monitoring as part of a surveillance program to control COVID-19 outbreaks at East Carolina University was evaluated...
2024: PloS One
#7
JOURNAL ARTICLE
Eleftheria Kampouri, Elizabeth M Krantz, Hu Xie, Sarah S Ibrahimi, Erika S Kiem, Mandeep K Sekhon, Emily C Liang, Andrew J Cowan, Andrew J Portuguese, Damian J Green, Aya Albittar, Jennifer J Huang, Jordan Gauthier, Ailyn C Pérez-Osorio, Keith R Jerome, Danielle Zerr, Michael J Boeckh, Joshua A Hill
Human herpesvirus-6B (HHV-6B) reactivation and disease are increasingly reported after CAR-T-cell therapy (CARTx). HHV-6 reactivation in the CAR-T-cell product was recently reported, raising questions about product and patient management. Due to overlapping manifestations with immune effector cell-associated neurotoxicity syndrome, diagnosing HHV-6B encephalitis is challenging. We provide two lines of evidence assessing the incidence and outcomes of HHV-6B after CARTx. First, in a prospective study with weekly HHV-6B testing for up to 12 weeks post-infusion, HHV-6B reactivation occurred in eight of 89 participants; three had chromosomally integrated HHV-6 and were excluded, resulting in a cumulative incidence of HHV-6B reactivation of 6% (95% confidence interval (CI), 2...
April 18, 2024: Blood
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JOURNAL ARTICLE
Xiaoqi Dai, Shuo Li, Song Song, Meng Chen, Honghong Xu, Xuekui Li, Menghan Zhang, Huaqiang Zhang, Haiyan Sun, Zhongdong Wang
INTRODUCTION: The purpose of this study is to assess the levels of knowledge, attitude, and practice (KAP) related to TB, and to analyze the differences among various demographic groups. METHODOLOGY: A total of 621 students enrolled in Qingdao High School, coming from high TB burden settings. The cross-sectional study was conducted from May to July of 2022. Participants completed an online questionnaire. Differences in knowledge and practice based on participant characteristics were analyzed using the Wilcoxon rank test and Kruskal-Wallis rank test...
March 31, 2024: Journal of Infection in Developing Countries
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JOURNAL ARTICLE
Rafaela Caroline C Melo, Mauro C Ramos, Maria Lúcia R Rossetti, Vera Mileide T Grassi, Maurício O Colvero, Thales Augusto Dt Marzarotto, Renan R Bonamigo
INTRODUCTION: Congenital syphilis (CS) has severe adverse outcomes, including abortion and death. Diagnosis of CS in asymptomatic newborns remains difficult. This study aims to evaluate an in-house polymerase chain reaction (PCR) on cerebrospinal fluid (CSF) and blood samples (BS) to identify T. pallidum DNA in newborns. METHODOLOGY: We performed an exploratory cross-sectional study that included newborns exposed to syphilis during pregnancy (SEG) and non-exposed (SNEG) newborns, between 2019 and 2020...
March 31, 2024: Journal of Infection in Developing Countries
#10
JOURNAL ARTICLE
Shahadat Uddin, Haohui Lu
Many individual studies in the literature observed the superiority of tree-based machine learning (ML) algorithms. However, the current body of literature lacks statistical validation of this superiority. This study addresses this gap by employing five ML algorithms on 200 open-access datasets from a wide range of research contexts to statistically confirm the superiority of tree-based ML algorithms over their counterparts. Specifically, it examines two tree-based ML (Decision tree and Random forest) and three non-tree-based ML (Support vector machine, Logistic regression and k-nearest neighbour) algorithms...
2024: PloS One
#11
JOURNAL ARTICLE
Heidy Martínez-Pacheco, Rossana Citlali Zepeda, Ofir Picazo, Gina L Quirarte, Gabriel Roldán-Roldán
While chronic stress induces learning and memory impairments, acute stress may facilitate or prevent memory consolidation depending on whether it occurs during the learning event or before it, respectively. On the other hand, it has been shown that histone acetylation regulates long-term memory formation. This study aimed to evaluate the effect of two inhibitors of class I histone deacetylases (HDACs), 4-phenylbutyrate (PB) and IN14 (100 mg/kg/day, ip for 2 days), on memory performance in mice exposed to a single 15-min forced swimming stress session...
2024: PloS One
#12
JOURNAL ARTICLE
Laura D Zambrano, Margaret M Newhams, Regina M Simeone, Amanda B Payne, Michael Wu, Amber O Orzel-Lockwood, Natasha B Halasa, Jemima M Calixte, Pia S Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E Schuster, Elizabeth H Mack, Austin Biggs, Bria M Coates, Kelly N Michelson, Katherine E Bline, Ryan A Nofziger, Hillary Crandall, Charlotte V Hobbs, Shira J Gertz, Sabrina M Heidemann, Tamara T Bradford, Tracie C Walker, Stephanie P Schwartz, Mary Allen Staat, Samina S Bhumbra, Janet R Hume, Michele Kong, Melissa S Stockwell, Thomas J Connors, Melissa L Cullimore, Heidi R Flori, Emily R Levy, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Cindy Bowens, Danielle M Zerr, Judith A Guzman-Cottrill, Ivan Gonzalez, Angela P Campbell, Adrienne G Randolph
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
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JOURNAL ARTICLE
Letícia R Morimoto, Daisy T Kase, Paola G Esmanhotto, Murilo A Maciel, Ana C L Augusto, Patrick F Catricala, Julia E C Anaya, Sugoto Mukherjee, Artur R C Fernandes, André Y Aihara
Nontraumatic pathologic conditions of the craniovertebral junction encompass a range of conditions affecting the complex anatomy of this region without direct physical injury. These conditions include congenital syndromes that predispose individuals to ligamentous laxity, potentially leading to instability. Additionally, rare but noteworthy cases such as Grisel syndrome, a cause of pediatric torticollis, may arise without a traumatic trigger. Inflammatory diseases, including rheumatoid arthritis, ankylosing spondylitis, and crystal deposition, can lead to cervical instability and spinal cord compression...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#14
JOURNAL ARTICLE
Elsa Maria Vasquez-Trespalacios, Jessica N Rivera Rivera, McKenzie McIntyre, Waleska Santiago-Datil, Robert M Wenham, Susan T Vadaparampil, Andrea L Buras, Claire C Conley
Ovarian cancer is considered the most fatal and costly gynecologic cancer. Although personalized therapies have improved ovarian cancer prognosis, they have resulted in increased financial toxicity concerns among this population. This study evaluated financial toxicity in patients with advanced ovarian cancer. Using secondary data from a study of barriers to palliative care, financial toxicity (FT) was measured through the Comprehensive Score for Financial Toxicity scale. Univariate and bivariate analyses were used to assess the relationship between selected demographic (i...
April 18, 2024: Journal of Social Work in End-of-life & Palliative Care
#15
JOURNAL ARTICLE
Chen Shi, Yixuan Tong, Liam Harris, Stephane Owusu-Sarpong, Jeffrey Goldstein
STUDY DESIGN: Retrospective Cohort Study Objectives: Robot-assisted spine surgery (RASS) is a rapidly evolving technique with potential benefits for improving surgical outcomes. A number of studies on RASS learning curve have focused on early iterations of the Mazor robot. Limited research exists on the learning curve associated with using the Globus Medical ExcelsiusGPS® system. In this retrospective study, we aimed to evaluate the learning curve of RASS using the ExcelsiusGPS® system at a single institution...
April 18, 2024: Global Spine Journal
#16
JOURNAL ARTICLE
Jeffrey J Tosoian, Yuping Zhang, Lanbo Xiao, Cassie Xie, Nathan L Samora, Yashar S Niknafs, Zoey Chopra, Javed Siddiqui, Heng Zheng, Grace Herron, Neil Vaishampayan, Hunter S Robinson, Kumaran Arivoli, Bruce J Trock, Ashley E Ross, Todd M Morgan, Ganesh S Palapattu, Simpa S Salami, Lakshmi P Kunju, Scott A Tomlins, Lori J Sokoll, Daniel W Chan, Sudhir Srivastava, Ziding Feng, Martin G Sanda, Yingye Zheng, John T Wei, Arul M Chinnaiyan
IMPORTANCE: Benefits of prostate cancer (PCa) screening with prostate-specific antigen (PSA) alone are largely offset by excess negative biopsies and overdetection of indolent cancers resulting from the poor specificity of PSA for high-grade PCa (ie, grade group [GG] 2 or greater). OBJECTIVE: To develop a multiplex urinary panel for high-grade PCa and validate its external performance relative to current guideline-endorsed biomarkers. DESIGN, SETTING, AND PARTICIPANTS: RNA sequencing analysis of 58 724 genes identified 54 markers of PCa, including 17 markers uniquely overexpressed by high-grade cancers...
April 18, 2024: JAMA Oncology
#17
JOURNAL ARTICLE
Jason D Jones, Karen T G Schwartz, Molly Davis, Robert Gallop, Benjamin L Hankin, Jami F Young
OBJECTIVE: To test potential cognitive and interpersonal moderators of two evidence-based youth depression prevention programs. METHOD: Two hundred four adolescents ( M age = 14.62 years, SD = 1.65; 56% female; 71% White, 11% Black, 11% multiracial, 5% Asian, 2% other races, 18% Hispanic/Latinx) were randomized to either a cognitive-behavioral (Coping With Stress [CWS]) or interpersonal (Interpersonal Psychotherapy-Adolescent Skills Training [IPT-AST]) prevention program...
April 18, 2024: Journal of Consulting and Clinical Psychology
#18
JOURNAL ARTICLE
Riley J Jouppi, Shannon D Donofry, Christine C Call, Yu Cheng, Rachel P Kolko Conlon, Sarah Niemi, Michele D Levine
OBJECTIVE: Loss of control (LOC) eating (feeling unable to control food type/amount eaten) during pregnancy is common and linked to risk for poor cardiovascular health (CVH), but it is unclear whether prenatal LOC eating directly relates to CVH during pregnancy. The current study tested associations between prenatal LOC eating and CVH during pregnancy in a sample with prepregnancy body mass index (BMI) ≥ 25. METHOD: At 12-20 weeks' gestation, participants ( N = 124) self-reported: prenatal LOC eating, diet, physical activity, nicotine use, sleep; height/weight were measured...
April 18, 2024: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
#19
JOURNAL ARTICLE
Christopher N Maymon, Matthew T Crawford, Katie Blackburne, André Botes, Kieran Carnegie, Samuel A Mehr, Jeremy Meier, Justin Murphy, Nicola L Miles, Kealagh Robinson, Michael Tooley, Gina M Grimshaw
When we become engrossed in novels, films, games, or even our own wandering thoughts, we can feel present in a reality distinct from the real world. Although this subjective sense of presence is, presumably, a ubiquitous aspect of conscious experience, the mechanisms that produce it are unknown. Correlational studies conducted in virtual reality have shown that we feel more present when we are afraid, motivating claims that physiological changes contribute to presence; however, such causal claims remain to be evaluated...
April 18, 2024: Journal of Experimental Psychology. General
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JOURNAL ARTICLE
Esperanza Pato-Cour, Lara Borrego-Sanz, Marta Domínguez-Álvaro, Fernando Sánchez-Alonso, Fayna Rodríguez-González, Marta Tejera-Santana, Mar Esteban-Ortega, Isabel García-Lozano, Lucia Martínez-Costa, Samuel González-Ocampo, Maite Sainz-de-la-Maza, Aina Moll-Udina, Zulema Plaza, Alejandro Fonollosa, Joseba Artaraz, Teresa Díaz-Valle, Maria Gurrea-Almela, David Díaz-Valle, Rosalía Méndez-Fernández
INTRODUCTION: This was a multicenter, prospective, longitudinal, observational study involving eight Spanish tertiary hospitals to determine the interobserver reliability of an uveitis disease activity index, (UVEDAI) and assess its sensitivity to change in patients with receiving pharmacologic treatment. METHODS: Patients aged ≥ 18 years diagnosed with active noninfectious uveitis were included. A complete baseline assessment was performed by two ophthalmologists who determined ocular inflammatory activity using the UVEDAI index independently of each other...
April 18, 2024: Ophthalmology and Therapy
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