Henriette Poaty, Philippe Coullin, Eric Leguern, Philippe Dessen, Alexandre Valent, José-Marie Afoutou, Jean-Félix Peko, Jean-Jacques Candelier, Charles Gombé-Mbalawa, Jean-Yves Picard, Alain Bernheim
The complete hydatidiform mole (CHM), a gestational trophoblastic disease, is usually caused by the development of an androgenic egg whose genome is exclusively paternal. Due to parental imprinting, only trophoblasts develop in the absence of a fetus. CHM are diploid and no abnormal karyotype is observed. It is 46,XX in most cases and less frequently 46,XY. The major complication of this disease is gestational choriocarcinoma, a metastasizing tumor and a true allografted malignancy. This complication is infrequent in developed countries, but is more common in the developing countries and is then worsened by delayed care...
September 2012: Bulletin du Cancer