keyword
https://read.qxmd.com/read/26221125/dna-flow-cytometric-analysis-in-variable-types-of-hydropic-placentas
#21
JOURNAL ARTICLE
Fatemeh Atabaki Pasdar, Alireza Khooei, Alireza Fazel, Maryam Rastin, Nafise Tabasi, Tahmineh Peirouvi, Mahmoud Mahmoudi
BACKGROUND: Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. OBJECTIVE: We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry. MATERIALS AND METHODS: DNA ploidy analysis was performed in 20 non-molar (hydropic and non-hydropic spontaneous abortions) and 20 molar (complete and partial moles), formalin-fixed, paraffin-embedded tissue samples by flow cytometry...
May 2015: Iranian Journal of Reproductive Medicine
https://read.qxmd.com/read/25613826/-twin-pregnancy-with-complete-hydatiform-mole-and-coexistent-fetus-report-of-4-cases-and-review-of-literature
#22
REVIEW
F de Marcillac, C Y Akladios, I Hui-bon-hoa, G Fritz, I Nisand, B Langer
OBJECTIVE: Twin pregnancy with complete hydatiform mole and coexistent fetus is a rare clinical condition, occurring in 1 in 22,000 to one in 100,000 pregnancies. Continuation of pregnancy in these cases is controversial because of a high risk of immediate and long-term maternal morbidity. It allows, however, in 33 % of the case the delivery of a healthy child. METHODS: This retrospective study included all patients presenting a complete hydatiform mole coexisting with a live twin fetus antenatally diagnosed between 2007 and 2012 in the level III maternity of the Strasbourg University Hospital...
November 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://read.qxmd.com/read/25538926/placenta-increta-as-an-important-cause-of-uterine-mass-after-first-trimester-curettage-case-report
#23
JOURNAL ARTICLE
Safoura Rouholamin, Fariba Behnamfar, Azam Zafarbakhsh
Placenta increta during the first trimester of pregnancy is very rare. This report describes two cases of placenta increta that caused prolonged vaginal bleeding after a first-trimester abortion. We were encountered two cases of placenta increta in October 2012 and May 2013. Case I: A 35-year-old patient with continues vaginal bleeding from 2 months after curettage due to missed abortion in the first trimester. The uterus was large, the human chorionic gonadotropin (BHCG) level was 112 mUI/mL and ultrasound showed an echogenic mass in the lower segment of the uterine cavity...
2014: Advanced Biomedical Research
https://read.qxmd.com/read/25499859/-gestational-trophoblastic-disease
#24
REVIEW
Fabienne Allias, Pierre-Adrien Bolze, Lucie Gaillot-Durand, Mojgan Devouassoux-Shisheboran
Gestational trophoblastic disease encompresses a group of interrelated diseases, following a pregnancy after a variable period of time. Hydatiform mole corresponds to premalignant disorders composed of villi with excess of paternal genetic material, with a malignant potential more important for complete mole than partial mole. Gestational trophoblastic neoplasia includes invasive mole, choriocarcinoma, placental site trophoblatic tumor and epithelioid trophoblastic tumor. Their histological diagnosis may be problematic on curettage material and needs to be correlated to serum hCG level and radiological findings...
December 2014: Annales de Pathologie
https://read.qxmd.com/read/25330692/gestational-trophoblastic-disease-psychological-aspects-and-fertility-issues
#25
JOURNAL ARTICLE
Valentina E Di Mattei, Letizia Carnelli, Alessandro Ambrosi, Giorgia Mangili, Massimo Candiani, Lucio Sarno
OBJECTIVE: To evaluate the impact of a forced delay in childbearing during thefollow-up period on the perceived fertility of patients with gestational trophoblastic disease (GTD), and to investigate how women react to the monitoring period, with particular attention to fertility concerns, personal perceptions of the impact of GTD on reproductive outcomes, and psychological symptoms of depression and anxiety. STUDY DESIGN: Twenty women treated for GTD at San Raffaele Hospital, Milan, took part in the study...
September 2014: Journal of Reproductive Medicine
https://read.qxmd.com/read/25126425/gestational-trophoblastic-disease-a-multimodality-imaging-approach-with-impact-on-diagnosis-and-management
#26
REVIEW
Sunita Dhanda, Subhash Ramani, Meenkashi Thakur
Gestational trophoblastic disease is a condition of uncertain etiology, comprised of hydatiform mole (complete and partial), invasive mole, choriocarcinoma, and placental site trophoblastic tumor. It arises from abnormal proliferation of trophoblastic tissue. Early diagnosis of gestational trophoblastic disease and its potential complications is important for timely and successful management of the condition with preservation of fertility. Initial diagnosis is based on a multimodality approach: encompassing clinical features, serial quantitative β-hCG titers, and pelvic ultrasonography...
2014: Radiology Research and Practice
https://read.qxmd.com/read/24867873/sonographic-findings-and-perinatal-outcome-of-multiple-pregnancies-associating-a-complete-hydatiform-mole-and-a-live-fetus-a-case-series
#27
JOURNAL ARTICLE
Mehmet Serdar Kutuk, Mahmut Tuncay Ozgun, Mehmet Dolanbay, Cem Batukan, Semih Uludag, Mustafa Basbug
BACKGROUND: The aim of this case series was to present the ultrasonographic findings, clinical features, management, and outcome of multiple pregnancies with complete hydatidiform mole and coexisting fetus (CHMCF). METHODS: Sonographic features and obstetrical and perinatal outcomes of seven cases with CHMCF were analyzed retrospectively. RESULTS: A total of seven cases was included in the analysis. Six cases were twins and one case was quadruplet...
October 2014: Journal of Clinical Ultrasound: JCU
https://read.qxmd.com/read/24581204/-twin-pregnancy-with-a-complete-hydatiform-mole-and-a-viable-co-twin
#28
JOURNAL ARTICLE
Ana Beatriz Godinho, Diana Martins, Cláudia Araújo, Maria Antonieta Melo, Luís Mendes Graça
A complete hydatiform mole coexisting with a live, viable twin is a rare event. The diagnosis is challenging, and is normally achieved only at second trimester. It may be associated with thyrotoxicosis, vaginal bleeding, preeclampsia, fetal death or persistent throphoblastic disease. The authors describe the case of a pregnant woman presenting with first trimester bleeding. Ultrasound revealed a twin pregnancy with a viable twin and another placenta apparently detached. At 16 gestational weeks ultrasound revealed a live fetus with a normal placenta and a separate vacuolated and vascularized mass...
January 2014: Acta Médica Portuguesa
https://read.qxmd.com/read/24318277/complete-hydatidiform-mole-and-a-coexistent-fetus-following-ovulation-induction-in-a-patient-with-sheehan-s-syndrome-a-first-case-report-and-review-of-literature
#29
REVIEW
Xuekun Huang, Jingyao Liang, Yonghan Huang, Juanhua Huang
Pregnancy in Sheehan's syndrome (SS) is extremely rare. We present the first reported case of twin pregnancy with complete hydatiform mole (CHM) and a coexistent fetus (CHCF) in a patient with SS. A 29-year-old Chinese patient with SS became pregnant following one cycle of ovulation induction with human menopausal gonadotropin after secondary infertility. A normal live fetus and a low echogenic mass suspected hydatidiform mole (HM) were detected by ultrasound examinations at gestational week 8. The couple highly desired to continue the pregnancy because it is very hard to get pregnant for the patients with SS...
May 2014: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/24313181/brain-metastases-of-choriocarcinoma-a-report-on-two-cases
#30
JOURNAL ARTICLE
Vera Milenković, Biljana Lazović, Ljiljana Mirković, Danica Grujicić, Radmila Sparić
INTRODUCTION: Gestational trophoblastic diseases (GTD) are a spectrum of tumors with a various of biological behavior and potential for metastases. It consists of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Choriocarcinoma presents a very aggressive tumor with high malignant potential. CASE REPORT: We presented the two cases of choriocarcinoma with brain metastases. The first one was manifested by neurological deterioration as the first sign of metastasis, while the second patient had firstly metrorrhagia and in the further couse neurological disturbances that suggested the presence of brain tumor...
October 2013: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://read.qxmd.com/read/23941020/spontaneous-ovarian-hyperstimulation-syndrome
#31
REVIEW
Miro Kasum, Slavko Oresković, Davor Jezek
Spontaneous forms of the ovarian hyperstimulation syndrome (sOHSS) are nearly always reported between 8 and 14 weeks of pregnancy and also with follicle-stimulating hormone (FSH) producing pituitary adenoma. The syndrome has been previously reported in rare instances of increased production of human chorionic gonadotrophin (hCG) such as multiple pregnancies, hydatiforme mole, polycystic ovary disease and elevated concentrations of thyroid-stimulating hormone (TSH) in hypothyreoidism. High levels of these hormones are able to stimulate by natural promiscuous activation the wild-type FSHr, resulting in sporadic presentations of the syndrome...
June 2013: Collegium Antropologicum
https://read.qxmd.com/read/23917362/congenital-adrenal-hyperplasia-and-pregnancy
#32
JOURNAL ARTICLE
Soulmaz Shorakae, Helena Teede
A 32-year-old woman with classical congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency presented with infertility. She was treated with different steroid replacement regimens together with fludrocortisone. The aim of this case report is to discuss fertility barriers in women with classical CAH, and emphasise the risks and benefits of available steroid treatment options. Clinical considerations covered include preconception health and fertility planning, optimising fertility through suppression of excess hormone production, reducing fetal androgen exposure in utero and limiting maternal and fetal side effects of therapy and limiting chances of CAH in the baby...
2013: BMJ Case Reports
https://read.qxmd.com/read/23420141/relation-between-single-serum-progesterone-assay-and-viability-of-the-first-trimester-pregnancy
#33
JOURNAL ARTICLE
Ibrahim A Abdelazim, Amro Abo Elezz, Mohamed Elsherbiny
This study was designed to detect the relation between serum progesterone and viability of pregnancy during the first trimester. Prospective study carried out in Al-Rashid Maternity and Ahmadi Kuwait oil company hospitals, over three years from February 2009 to February 2012. Two hundred and Sixty (260) pregnant women were hospitalized due to vaginal bleeding and/or abdominal pain during the first trimester of their pregnancies and were included in this study. Women included in this study were; sure of dates, conceived spontaneously with no history of infertility and had a positive serum pregnancy test...
December 2012: SpringerPlus
https://read.qxmd.com/read/23126487/does-cerclage-improve-neonatal-outcomes-in-a-molar-pregnancy-and-a-coexistent-fetus-a-case-report
#34
JOURNAL ARTICLE
Eduardo Aguin, Victor Aguin, Ligia Cisneros, Tina Aguin, Cosmas Van de Ven, Ray Bahado-Singh
BACKGROUND: Complete hydatiform mole and coexistent viable fetus is very rare. The use of a cervical cerclage for cervical indications in the presence of this condition has never been reported. Although the diagnosis was made postnatal, the objective is to present a case with good neonatal outcome. CASE PRESENTATION: A patient presented with vaginal spotting around 23 weeks. She has a history of four preterm deliveries. Her cervix was dilated and a cerclage was placed...
2012: BMC Research Notes
https://read.qxmd.com/read/22877883/-cytogenomic-studies-of-hydatiform-moles-and-gestational-choriocarcinoma
#35
JOURNAL ARTICLE
Henriette Poaty, Philippe Coullin, Eric Leguern, Philippe Dessen, Alexandre Valent, José-Marie Afoutou, Jean-Félix Peko, Jean-Jacques Candelier, Charles Gombé-Mbalawa, Jean-Yves Picard, Alain Bernheim
The complete hydatidiform mole (CHM), a gestational trophoblastic disease, is usually caused by the development of an androgenic egg whose genome is exclusively paternal. Due to parental imprinting, only trophoblasts develop in the absence of a fetus. CHM are diploid and no abnormal karyotype is observed. It is 46,XX in most cases and less frequently 46,XY. The major complication of this disease is gestational choriocarcinoma, a metastasizing tumor and a true allografted malignancy. This complication is infrequent in developed countries, but is more common in the developing countries and is then worsened by delayed care...
September 2012: Bulletin du Cancer
https://read.qxmd.com/read/22801599/-frequency-of-hydatidiform-mole-in-tissue-obtained-by-curettage
#36
JOURNAL ARTICLE
Andressa Biscaro, Sheila Koettker Silveira, Giovani de Figueiredo Locks, Lívia Ribeiro Mileo, João Péricles da Silva Júnior, Péricles Pretto
PURPOSE: To determine the frequency of hydatiform mole in tissues obtained by curettage. METHODS: A cross-sectional, prospective and descriptive conducted on patients who underwent curretage due to a diagnosis of abortion or hydatiform mole whose material was sent for pathological examination. We excluded women who did not accept to participate and refused to sign the free informed consent form. We studied the following variables: pathological findings, age, race, number of pregnancies and previous abortions, gestational age at diagnosis, quantitative serum beta fraction of human chorionic gonadotropin and ultrasound findings...
June 2012: Revista Brasileira de Ginecologia e Obstetrícia
https://read.qxmd.com/read/22369004/-morbidity-and-mortality-of-patients-suffering-from-gestational-trophoblastic-diseases-at-the-clinic-of-gynecology-and-obstetrics-clinical-center-of-serbia-in-the-period-from-2000-to-2007
#37
JOURNAL ARTICLE
Biljana Lazović, Vera Milenković, Ljiljana Mirković
INTRODUCTION: Gestational trophoblastic disease is a heterogenous group of diseases with malignant potential. The aim of this retrospective study was to evaluate potential risk factors in pathogenesis of gestational trophoblastic disease, its morbidity and mortality as well as treatment results. METHOD: We investigated 82 patients who were treated at the University Clinic of Gynecology and Obstetrics Clinical Center of Serbia from Jan 1st 2000 to Dec 31st 2007. The data were collected from their hospital charts and referred to gynecological anamnesis, diagnosis, protocols of operated patients, diagnosis, histopathological findings, decisions of expert team for trophoblastic disease and hospital discharge...
November 2011: Medicinski Pregled
https://read.qxmd.com/read/22157338/understanding-hydatidiform-mole
#38
JOURNAL ARTICLE
Mary Digiulio, Susan Wiedaseck, Ruth Monchek
Hydatidiform mole (often referred to as molar pregnancy) is the most common disorder in a category of pathologies known as Gestational Trophoblastic Diseases that are associated with abnormal fertilization in pregnancy. Current practices in screening and monitoring during early pregnancy allow for better identification of hydatidiform mole, sometimes prior to the onset of significant symptoms.Once a diagnosis is established, a thorough physical examination and laboratory testing are necessary. Initial treatment includes uterine evacuation...
January 2012: MCN. the American Journal of Maternal Child Nursing
https://read.qxmd.com/read/22085657/gestatational-trophoblastic-disease-multimodality-imaging-assessment-with-special-emphasis-on-spectrum-of-abnormalities-and-value-of-imaging-in-staging-and-management-of-disease
#39
REVIEW
Kimia Khalatbari Kani, Jean H Lee, Manjiri Dighe, Mariam Moshiri, Orpheus Kolokythas, Theodore Dubinsky
Gestational trophoblastic disease is a spectrum of disorders of varying malignant potential arising from trophoblastic cells and encompassing hydatidiform moles and persistent trophoblastic neoplasia. Ultrasound is the initial imaging investigation of choice when gestational trophoblastic disease is suspected. Complete hydatiform mole, the most common form of molar pregnancy, usually has a characteristic "cluster of grapes" appearance, especially on second-trimester ultrasounds. Persistent trophobastic neoplasia usually appears as a focal, hypervascular myometrial mass on pelvic ultrasound...
January 2012: Current Problems in Diagnostic Radiology
https://read.qxmd.com/read/21888177/triplet-pregnancy-with-partial-hydatiform-mole
#40
JOURNAL ARTICLE
M Siva Sundari, Preet Agarwal, Jayanthi Mohan
Triplet pregnancy with a coexisting mole is extremely rare. A 26 years old primigravida with multiple gestation and severe pre-eclampsia at 32 weeks gestation was brought to Sri Ramachandra University casualty. In view of abnormal Doppler study with discordant twins emergency lower segment caesarean section was done six days later. Part of the placenta showed molar changes. Histopathology confirmed partial mole. Patient received three cycles of methotrexate in view of rising titres of betahCG. Three months after delivery both babies are alive and well and betahCG for the mother became normal...
February 2011: Journal of the Indian Medical Association
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