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https://www.readbyqxmd.com/read/27485461/a-hellp-syndrome-complicates-a-gestational-trophoblastic-neoplasia-in-a-perimenopausal-woman-a-case-report
#1
Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber
BACKGROUND: HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01-0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy. This manuscript describes the only reported case of HELLP syndrome associated with a complete invasive hydatiform mole. CASE PRESENTATION: We report a perimenopausal patient in prolonged remission from an uncommon high-risk invasive complete mole...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27354611/prognosis-of-patients-with-gestational-trophoblastic-neoplasia-and-obstetric-outcomes-of-those-conceiving-after-chemotherapy
#2
Angiolo Gadducci, Stefania Cosio, Antonio Fanucchi, Roberta Tana, Simona Manacorda, Sabina Pistolesi, Francesca Letizia Strigini
AIM: To assess prognosis of gestational trophoblastic neoplasia (GTN) and obstetric outcome after chemotherapy. PATIENTS AND METHODS: Sixty-six patients had diagnosis of hydatiform mole on curettage and 18 developed GTN. Two patients were referred with pathological diagnosis of GTN. Chemotherapy was tailored according to International Federation of Gynecology and Obstetrics risk scoring system. RESULTS: All patients with GTN but one, were recovered by chemotherapy and had no evidence of disease after a median follow-up of 80 months...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27042562/spinal-anaesthesia-is-safe-in-a-patient-with-wolff-parkinson-white-syndrome-undergoing-evacuation-of-molar-pregnancy
#3
Pravalika Deviseti, Vinayak S Pujari
Wolff-Parkinson-White (WPW) syndrome is an uncommon cardiac condition where there is an abnormal band of atrial tissue connecting atria and ventricles which can electrically bypass atrioventricular node. The anaesthetic management in these patients is challenging as life threatening complications can occur perioperatively like paroxysmal supraventricular tachycardia and atrial fibrillation. Also, regional anaesthetic technique like subarachnoid block is a safe and cost effective alternative to general anaesthesia as it avoids polypharmacy...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26999911/false-negative-urine-pregnancy-testing-with-complete-molar-pregnancy-an-example-of-the-hook-effect
#4
Zachary Anderson, Eric Larson, Muhammad Khan, Maria Bell
INTRODUCTION: Gestational trophoblastic disease (GTD) encompasses a group of tumors derived from trophoblasts, which normally form the placenta during pregnancy. Human chorionic gonadotropin (hCG) is a glycoprotein composed of an alpha subunit identical to that of thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Detection of beta-hCG is achievable in both urine and serum samples, proving useful for the detection of normal pregnancy and GTD...
February 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/26288335/reproductive-outcomes-after-hydatiform-mole-and-gestational-trophoblastic-neoplasia
#5
REVIEW
Angiolo Gadducci, Nora Lanfredini, Stefania Cosio
Gestational trophoblastic disease includes complete hydatidiform mole (CHM) or partial hydatidiform mole (PHM) and gestational trophoblastic neoplasia (GTN). Given the very high-curability rate of trophoblastic disease, the risk of further molar pregnancy after CHM or PHM as well as the risk of second primary tumors and fertility compromise after chemotherapy for GTN represent major concerns. The incidence of subsequent molar pregnancy ranges from 0.7 to 2.6% after one CHM or PHM, and is approximately 10% after two previous CHMs...
2015: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26221125/dna-flow-cytometric-analysis-in-variable-types-of-hydropic-placentas
#6
Fatemeh Atabaki Pasdar, Alireza Khooei, Alireza Fazel, Maryam Rastin, Nafise Tabasi, Tahmineh Peirouvi, Mahmoud Mahmoudi
BACKGROUND: Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. OBJECTIVE: We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry. MATERIALS AND METHODS: DNA ploidy analysis was performed in 20 non-molar (hydropic and non-hydropic spontaneous abortions) and 20 molar (complete and partial moles), formalin-fixed, paraffin-embedded tissue samples by flow cytometry...
May 2015: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25613826/-twin-pregnancy-with-complete-hydatiform-mole-and-coexistent-fetus-report-of-4%C3%A2-cases-and-review-of-literature
#7
REVIEW
F de Marcillac, C Y Akladios, I Hui-bon-hoa, G Fritz, I Nisand, B Langer
OBJECTIVE: Twin pregnancy with complete hydatiform mole and coexistent fetus is a rare clinical condition, occurring in 1 in 22,000 to one in 100,000 pregnancies. Continuation of pregnancy in these cases is controversial because of a high risk of immediate and long-term maternal morbidity. It allows, however, in 33 % of the case the delivery of a healthy child. METHODS: This retrospective study included all patients presenting a complete hydatiform mole coexisting with a live twin fetus antenatally diagnosed between 2007 and 2012 in the level III maternity of the Strasbourg University Hospital...
November 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/25538926/placenta-increta-as-an-important-cause-of-uterine-mass-after-first-trimester-curettage-case-report
#8
Safoura Rouholamin, Fariba Behnamfar, Azam Zafarbakhsh
Placenta increta during the first trimester of pregnancy is very rare. This report describes two cases of placenta increta that caused prolonged vaginal bleeding after a first-trimester abortion. We were encountered two cases of placenta increta in October 2012 and May 2013. Case I: A 35-year-old patient with continues vaginal bleeding from 2 months after curettage due to missed abortion in the first trimester. The uterus was large, the human chorionic gonadotropin (BHCG) level was 112 mUI/mL and ultrasound showed an echogenic mass in the lower segment of the uterine cavity...
2014: Advanced Biomedical Research
https://www.readbyqxmd.com/read/25499859/-gestational-trophoblastic-disease
#9
REVIEW
Fabienne Allias, Pierre-Adrien Bolze, Lucie Gaillot-Durand, Mojgan Devouassoux-Shisheboran
Gestational trophoblastic disease encompresses a group of interrelated diseases, following a pregnancy after a variable period of time. Hydatiform mole corresponds to premalignant disorders composed of villi with excess of paternal genetic material, with a malignant potential more important for complete mole than partial mole. Gestational trophoblastic neoplasia includes invasive mole, choriocarcinoma, placental site trophoblatic tumor and epithelioid trophoblastic tumor. Their histological diagnosis may be problematic on curettage material and needs to be correlated to serum hCG level and radiological findings...
December 2014: Annales de Pathologie
https://www.readbyqxmd.com/read/25330692/gestational-trophoblastic-disease-psychological-aspects-and-fertility-issues
#10
Valentina E Di Mattei, Letizia Carnelli, Alessandro Ambrosi, Giorgia Mangili, Massimo Candiani, Lucio Sarno
OBJECTIVE: To evaluate the impact of a forced delay in childbearing during thefollow-up period on the perceived fertility of patients with gestational trophoblastic disease (GTD), and to investigate how women react to the monitoring period, with particular attention to fertility concerns, personal perceptions of the impact of GTD on reproductive outcomes, and psychological symptoms of depression and anxiety. STUDY DESIGN: Twenty women treated for GTD at San Raffaele Hospital, Milan, took part in the study...
September 2014: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25126425/gestational-trophoblastic-disease-a-multimodality-imaging-approach-with-impact-on-diagnosis-and-management
#11
REVIEW
Sunita Dhanda, Subhash Ramani, Meenkashi Thakur
Gestational trophoblastic disease is a condition of uncertain etiology, comprised of hydatiform mole (complete and partial), invasive mole, choriocarcinoma, and placental site trophoblastic tumor. It arises from abnormal proliferation of trophoblastic tissue. Early diagnosis of gestational trophoblastic disease and its potential complications is important for timely and successful management of the condition with preservation of fertility. Initial diagnosis is based on a multimodality approach: encompassing clinical features, serial quantitative β-hCG titers, and pelvic ultrasonography...
2014: Radiology Research and Practice
https://www.readbyqxmd.com/read/24867873/sonographic-findings-and-perinatal-outcome-of-multiple-pregnancies-associating-a-complete-hydatiform-mole-and-a-live-fetus-a-case-series
#12
Mehmet Serdar Kutuk, Mahmut Tuncay Ozgun, Mehmet Dolanbay, Cem Batukan, Semih Uludag, Mustafa Basbug
BACKGROUND: The aim of this case series was to present the ultrasonographic findings, clinical features, management, and outcome of multiple pregnancies with complete hydatidiform mole and coexisting fetus (CHMCF). METHODS: Sonographic features and obstetrical and perinatal outcomes of seven cases with CHMCF were analyzed retrospectively. RESULTS: A total of seven cases was included in the analysis. Six cases were twins and one case was quadruplet...
October 2014: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/24581204/-twin-pregnancy-with-a-complete-hydatiform-mole-and-a-viable-co-twin
#13
Ana Beatriz Godinho, Diana Martins, Cláudia Araújo, Maria Antonieta Melo, Luís Mendes Graça
A complete hydatiform mole coexisting with a live, viable twin is a rare event. The diagnosis is challenging, and is normally achieved only at second trimester. It may be associated with thyrotoxicosis, vaginal bleeding, preeclampsia, fetal death or persistent throphoblastic disease. The authors describe the case of a pregnant woman presenting with first trimester bleeding. Ultrasound revealed a twin pregnancy with a viable twin and another placenta apparently detached. At 16 gestational weeks ultrasound revealed a live fetus with a normal placenta and a separate vacuolated and vascularized mass...
January 2014: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/24318277/complete-hydatidiform-mole-and-a-coexistent-fetus-following-ovulation-induction-in-a-patient-with-sheehan-s-syndrome-a-first-case-report-and-review-of-literature
#14
REVIEW
Xuekun Huang, Jingyao Liang, Yonghan Huang, Juanhua Huang
Pregnancy in Sheehan's syndrome (SS) is extremely rare. We present the first reported case of twin pregnancy with complete hydatiform mole (CHM) and a coexistent fetus (CHCF) in a patient with SS. A 29-year-old Chinese patient with SS became pregnant following one cycle of ovulation induction with human menopausal gonadotropin after secondary infertility. A normal live fetus and a low echogenic mass suspected hydatidiform mole (HM) were detected by ultrasound examinations at gestational week 8. The couple highly desired to continue the pregnancy because it is very hard to get pregnant for the patients with SS...
May 2014: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/24313181/brain-metastases-of-choriocarcinoma-a-report-on-two-cases
#15
Vera Milenković, Biljana Lazović, Ljiljana Mirković, Danica Grujicić, Radmila Sparić
INTRODUCTION: Gestational trophoblastic diseases (GTD) are a spectrum of tumors with a various of biological behavior and potential for metastases. It consists of hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. Choriocarcinoma presents a very aggressive tumor with high malignant potential. CASE REPORT: We presented the two cases of choriocarcinoma with brain metastases. The first one was manifested by neurological deterioration as the first sign of metastasis, while the second patient had firstly metrorrhagia and in the further couse neurological disturbances that suggested the presence of brain tumor...
October 2013: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/23941020/spontaneous-ovarian-hyperstimulation-syndrome
#16
REVIEW
Miro Kasum, Slavko Oresković, Davor Jezek
Spontaneous forms of the ovarian hyperstimulation syndrome (sOHSS) are nearly always reported between 8 and 14 weeks of pregnancy and also with follicle-stimulating hormone (FSH) producing pituitary adenoma. The syndrome has been previously reported in rare instances of increased production of human chorionic gonadotrophin (hCG) such as multiple pregnancies, hydatiforme mole, polycystic ovary disease and elevated concentrations of thyroid-stimulating hormone (TSH) in hypothyreoidism. High levels of these hormones are able to stimulate by natural promiscuous activation the wild-type FSHr, resulting in sporadic presentations of the syndrome...
June 2013: Collegium Antropologicum
https://www.readbyqxmd.com/read/23917362/congenital-adrenal-hyperplasia-and-pregnancy
#17
Soulmaz Shorakae, Helena Teede
A 32-year-old woman with classical congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency presented with infertility. She was treated with different steroid replacement regimens together with fludrocortisone. The aim of this case report is to discuss fertility barriers in women with classical CAH, and emphasise the risks and benefits of available steroid treatment options. Clinical considerations covered include preconception health and fertility planning, optimising fertility through suppression of excess hormone production, reducing fetal androgen exposure in utero and limiting maternal and fetal side effects of therapy and limiting chances of CAH in the baby...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/23420141/relation-between-single-serum-progesterone-assay-and-viability-of-the-first-trimester-pregnancy
#18
Ibrahim A Abdelazim, Amro Abo Elezz, Mohamed Elsherbiny
This study was designed to detect the relation between serum progesterone and viability of pregnancy during the first trimester. Prospective study carried out in Al-Rashid Maternity and Ahmadi Kuwait oil company hospitals, over three years from February 2009 to February 2012. Two hundred and Sixty (260) pregnant women were hospitalized due to vaginal bleeding and/or abdominal pain during the first trimester of their pregnancies and were included in this study. Women included in this study were; sure of dates, conceived spontaneously with no history of infertility and had a positive serum pregnancy test...
December 2012: SpringerPlus
https://www.readbyqxmd.com/read/23126487/does-cerclage-improve-neonatal-outcomes-in-a-molar-pregnancy-and-a-coexistent-fetus-a-case-report
#19
Eduardo Aguin, Victor Aguin, Ligia Cisneros, Tina Aguin, Cosmas Van de Ven, Ray Bahado-Singh
BACKGROUND: Complete hydatiform mole and coexistent viable fetus is very rare. The use of a cervical cerclage for cervical indications in the presence of this condition has never been reported. Although the diagnosis was made postnatal, the objective is to present a case with good neonatal outcome. CASE PRESENTATION: A patient presented with vaginal spotting around 23 weeks. She has a history of four preterm deliveries. Her cervix was dilated and a cerclage was placed...
2012: BMC Research Notes
https://www.readbyqxmd.com/read/22877883/-cytogenomic-studies-of-hydatiform-moles-and-gestational-choriocarcinoma
#20
Henriette Poaty, Philippe Coullin, Eric Leguern, Philippe Dessen, Alexandre Valent, José-Marie Afoutou, Jean-Félix Peko, Jean-Jacques Candelier, Charles Gombé-Mbalawa, Jean-Yves Picard, Alain Bernheim
The complete hydatidiform mole (CHM), a gestational trophoblastic disease, is usually caused by the development of an androgenic egg whose genome is exclusively paternal. Due to parental imprinting, only trophoblasts develop in the absence of a fetus. CHM are diploid and no abnormal karyotype is observed. It is 46,XX in most cases and less frequently 46,XY. The major complication of this disease is gestational choriocarcinoma, a metastasizing tumor and a true allografted malignancy. This complication is infrequent in developed countries, but is more common in the developing countries and is then worsened by delayed care...
September 2012: Bulletin du Cancer
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