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https://www.readbyqxmd.com/read/28638302/extended-stability-and-sterility-of-antihemophilic-factor-human
#1
Sarah Shields, Abby Kim, Joshua Elder
OBJECTIVES: Antihemophilic factor human is a factor VIII product used to supplement those with hemophilia. Recent data show treatment benefit and cost saving opportunities if factor products are administered as a continuous infusion rather than conventional bolus dose. This method has not been widely used given the lack of evidence for safe and effective use beyond 3 hours from preparation. The objectives of this study were to determine the physical and chemical stability and sterility of antihemophilic factor human over a 7-day period...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28637897/heritability-of-resting-heart-rate-and-association-with-mortality-in-middle-aged-and-elderly-twins
#2
Magnus T Jensen, Mette Wod, Søren Galatius, Jacob B Hjelmborg, Gorm B Jensen, Kaare Christensen
OBJECTIVE: Resting heart rate (RHR) possibly has a hereditary component and is associated with longevity. We used the classical biometric twin study design to investigate the heritability of RHR in a population of middle-aged and elderly twins and, furthermore, studied the association between RHR and mortality. METHODS: In total, 4282 twins without cardiovascular disease were included from the Danish Twin Registry, hereof 1233 twin pairs and 1816 'single twins' (twins with a non-participating co-twin); mean age 61...
June 21, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28634035/psoriasis-associated-late-cornified-envelope-lce-proteins-have-antibacterial-activity
#3
Hanna Niehues, Lam C Tsoi, Danique A van der Krieken, Patrick A M Jansen, Merel A W Oortveld, Diana Rodijk-Olthuis, Ivonne M J J van Vlijmen, Wiljan J A J Hendriks, Richard W Helder, Joke A Bouwstra, Ellen H van den Bogaard, Philip E Stuart, Rajan P Nair, James T Elder, Patrick L J M Zeeuwen, Joost Schalkwijk
Terminally differentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins that are involved in the physical barrier function of the stratum corneum and provide innate cutaneous host defense. Late cornified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encode a family of 18 proteins of unknown function, whose expression is largely restricted to epidermis. Deletion of two members, LCE3B and LCE3C (LCE3B/C-del), is a widely replicated psoriasis risk factor that interacts with the major psoriasis-psoriasis risk gene HLA-C*06...
June 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28631524/the-association-between-social-jetlag-the-metabolic-syndrome-and-type-2-diabetes-mellitus-in-the-general-population-the-new-hoorn-study
#4
Anitra D M Koopman, Simone P Rauh, Esther van 't Riet, Lenka Groeneveld, Amber A van der Heijden, Petra J Elders, Jacqueline M Dekker, Giel Nijpels, Joline W Beulens, Femke Rutters
Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined the association of social jetlag with the metabolic syndrome and type 2 diabetes mellitus in a population-based cohort. We used cross-sectional data from the New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social jetlag was calculated as the difference in midpoint sleep (in hours) between weekdays and weekend days. Poisson and linear regression models were used to study the associations, and age was regarded as a possible effect modifier...
June 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28629294/prevalence-of-insomnia-and-related-impact
#5
Manchumad Manjavong, Panita Limpawattana, Pisaln Mairiang, Sirirat Anutrakulchai
Background Sleep problem is a common geriatric condition that can result in various outcomes, both physical and mental, that reduce quality of life. The studies regarding the prevalence and impact of insomnia on daily activities in Thailand in pre-elderly and elderly adults are few. Objectives The primary objective of this study was to determine the prevalence of insomnia among pre-elderly and elderly populations and the secondary objective was to study the impact of insomnia on their daily lives. Methods This study included the participants from the urban middle class in the pre-retirement age of 50 years or older adults who worked for Khon Kaen University (KKU), Khon Kaen, Thailand, and their elderly relatives...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28627232/development-and-validation-of-the-self-awareness-of-falls-in-elderly-scale-among-elderly-inpatients
#6
Meei-Ling Shyu, Hui-Chuan Huang, Mei-Jung Wu, Hsiu-Ju Chang
The objectives of this study were to develop the Self-Awareness of Falls in Elderly (SAFE) scale and test its reliability and validity among elderly inpatients. A cross-sectional study design and convenience sampling were used to test the validity and reliability of the SAFE scale. Explanatory factor analysis and confirmatory factor analysis yielded an acceptable goodness of model fit, confirming the 21 items in the SAFE scale that were distributed among four factors: awareness of activity safety and environment, awareness of physical functions, awareness of medication, and awareness of cognitive behavior...
June 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28621563/reduced-mastication-impairs-memory-function
#7
Y Fukushima-Nakayama, Takehito Ono, M Hayashi, M Inoue, H Wake, Takashi Ono, T Nakashima
Mastication is an indispensable oral function related to physical, mental, and social health throughout life. The elderly tend to have a masticatory dysfunction due to tooth loss and fragility in the masticatory muscles with aging, potentially resulting in impaired cognitive function. Masticatory stimulation has influence on the development of the central nervous system (CNS) as well as the growth of maxillofacial tissue in children. Although the relationship between mastication and cognitive function is potentially important in the growth period, the cellular and molecular mechanisms have not been sufficiently elucidated...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28620227/gene-physical-activity-interactions-in-lower-extremity-performance-inflammatory-genes-crp-tnf-%C3%AE-and-lta-in-community-dwelling-elders
#8
Chiu-Shong Liu, Tsai-Chung Li, Chia-Ing Li, Li-Na Liao, Chuan-Wei Yang, Chih-Hsueh Lin, Nai-Hsin Meng, Wen-Yuan Lin, Sung-Lin Hu, Jen-Hao Hsiao, Fang-Yang Wu, Cheng-Chieh Lin
We assessed gene-gene and gene-physical activity interactions of polymorphisms in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and lymphotoxin α (LTA) genes on lower extremity performance in community-dwelling elders in Taiwan. Five SNPs (rs1205, rs1130864, rs1800947, rs2794520, and rs3093059) of CRP gene, three SNPs (rs909253, rs1041981, and rs2239704) of LTA gene, and three SNPs (rs3093662, rs1800629, and rs1799964) of TNF-α gene of 472 unrelated elders were genotyped. Lower extremity performance included timed up-and-go test (TUG), walking speed, weight-adjusted leg press (waLP), and timed chair stand (TCS)...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619301/the-effects-of-gua-sha-on-symptoms-and-inflammatory-biomarkers-associated-with-chronic-low-back-pain-a-randomized-active-controlled-crossover-pilot-study-in-elderly
#9
John W M Yuen, William W N Tsang, Sonny H M Tse, Wings T Y Loo, Suk-Tak Chan, Diana L Y Wong, Hilary H Y Chung, Jacky K K Tam, Thomas K S Choi, Vico C L Chiang
OBJECTIVE: To address the challenges for trialing with elderly and the lacking of valid sham/placebo control, a randomized crossover pilot study is designed and its feasibility on elderly subjects is evaluated. DESIGN: A pilot randomized crossover study was conducted with hydrocollator-based hot pack therapy as active control. Pain intensity, physical disability, depression, general health status, and salivary biomarkers were assessed as outcome measures. RESULTS: Despite there was no significant difference observed between any outcome measures attained by the two interventions, several important differences were noted during the one-week follow-up period...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618742/the-turkish-version-of-the-physical-activity-scale-for-the-elderly-pase-its-cultural-adaptation-validation-and-reliability
#10
Ender Ayvat, Muhammed Kilinç, Nuray Kirdi
BACKGROUND/AIM: This study aimed to describe the cultural adaptation of the Turkish Physical Activity Scale for the Elderly (PASE) and to examine the reliability and validity of the scale in older Turkish adults. MATERIALS AND METHODS: Eighty elderly people were recruited for the study. The assessments included the PASE, the International Physical Activity Questionnaire (IPAQ), the Short Physical Performance Battery and Short Form-36 Quality of Life Questionnaire (SF-36), and the Mini Mental State Test...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618733/pain-depression-levels-fatigue-sleep-quality-and-quality-of-life-in-elderly-patients-with-rheumatoid-arthritis
#11
İlknur Albayrak Gezer, Ayşe Balkarli, Beray Can, Sinan Bağçaci, Sami Küçükşen, Adem Küçük
BACKGROUND/AIM: The aim of this study was to evaluate and determine the relationships (if any) among pain, depression levels, fatigue, sleep quality, and quality of life in patients with rheumatoid arthritis (RA) aged 65 years and over, and to compare the results with those of RA patients under 65 years of age. MATERIALS AND METHODS: The study included 52 patients with RA aged 65 years and over (Group 1) and 84 patients with RA under 65 years of age (Group 2). Pain, depression levels, fatigue, sleep quality, quality of life, and disease activity of all of the participants were evaluated using a visual analog scale (VAS), the Beck Depression Inventory (BDI), the Checklist Individual Strength (CIS), the Pittsburgh Sleep Quality Index (PSQI), the Short Form-36 (SF-36), and the Disease Activity Score-28, respectively...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28612640/do-exercise-habits-during-middle-age-affect-locomotive-syndrome-in-old-age
#12
Akinobu Nishimura, Naoya Ito, Kunihiro Asanuma, Koji Akeda, Toru Ogura, Akihiro Sudo
OBJECTIVES: Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS: We examined 460 participants of the eighth, ninth, and tenth iterations of the Miyagawa study. Participants were divided into an LS group and a no-LS group according to their scores on the 25-question Geriatric Locomotive Function Scale...
June 14, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28607643/retirement-homes-social-participation-and-quality-of-life
#13
Elham Amiri, Farzad Faraji Khiavi, Hossine Dargahi, Esmat Dastjerd
INTRODUCTION: Social participation is considered as a means of improving one's quality of life, thus the study aimed at assessing the association between the quality of life and social participation in the elderly. METHODS: This cross-sectional study was conducted in 2016. The study population was selected from among the residents of a retirement home (an elderly residential home) in one of the Northwestern provinces of Iran, and the required data was collected via three questionnaires related to the demographic data, the specific quality of life for the elderly (LEIPAD), and the extent of social participation...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28607235/meeting-the-current-and-future-health-care-needs-of-sri-lanka-s-ageing-population
#14
Dilhar Samaraweera, Shiromi Maduwage
Sri Lanka is one of the fastest-ageing countries in the world. This rapid demographic transition is expected to result in one quarter of the population being elderly by the year 2041. Profound challenges face the country as a result, especially with respect to planning adequate elderly-oriented services in the social-care and health-care sectors. In response to this need, many initiatives have been put in place to promote and protect the welfare of older people, and these rights have been inscribed in law. Within the health sector, despite the wealth of policies and initiatives in recent years, it is clear that the existing health infrastructure and systems still require strengthening, reorientation and coordination, to meet the needs of the growing population of elderly individuals...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28606710/leisure-time-physical-activity-and-risk-of-disability-incidence-a-12-year-prospective-cohort-study-among-young-elderly-of-the-same-age-at-baseline
#15
Takashi Matsunaga, Mariko Naito, Kenji Wakai, Shigekazu Ukawa, Wenjing Zhao, Satoe Okabayashi, Masahiko Ando, Takashi Kawamura, Akiko Tamakoshi
BACKGROUND: To clarify the role of physical activity in preventing disability in Japan, we investigated the association between amount of leisure-time physical activity and incidence of disability among the young elderly. METHODS: In the New Integrated Suburban Seniority Investigation (NISSIN) project conducted from 1996 to 2013, we followed 2888 community-dwelling adults aged 64-65 years with no history of cerebrovascular disease for a median follow-up of 11.6 years...
June 9, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28606408/-common-therapeutic-approaches-of-sarcopenia-in-the-elderly-and-uremic-myopathy
#16
Philippe Chauveau, Karine Moreau, Catherine Lasseur, Christian Combe, Michel Aparicio
The gradual loss of weight and function of muscle in patients with chronic kidney disease as in the elderly impacts the quality of life. Early management should help slow the functional limitation. Physical activity is the first therapy to propose that ensures stability of muscle mass and improved function. Resistance training programs have proven effective but are not yet widely available in nephrology units. The nutritional management should not be forgotten because there is a resistance to anabolism and protein intake should be involved in physical activity program...
June 9, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28605043/typical-angina-is-associated-with-greater-coronary-endothelial-dysfunction-but-not-abnormal-vasodilatory-reserve
#17
Ahmed AlBadri, Derek Leong, C Noel Bairey Merz, Janet Wei, Eileen M Handberg, Chrisandra L Shufelt, Puja K Mehta, Michael D Nelson, Louise E Thomson, Daniel S Berman, Leslee J Shaw, Galen Cook-Wiens, Carl J Pepine
BACKGROUND: Typical angina (TA) is defined as substernal chest pain precipitated by physical exertion or emotional stress and relieved with rest or nitroglycerin. Women and elderly patients are usually have atypical symptoms both at rest and during stress, often in the setting of nonobstructive coronary artery disease (CAD). HYPOTHESIS: To further understand this, we performed subgroup analysis comparing subjects who presented with TA vs nontypical angina (NTA) using baseline data of patients with nonobstructive CAD and coronary microvascular dysfunction (CMD) enrolled in a clinical trial...
June 12, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28603380/improved-functional-independence-measure-facilitates-return-to-home-after-paralyzed-upper-limb-training-a-case-report
#18
Kuniaki Nagai, Fumiaki Yamaguchi
[Purpose] We report a case in which rehabilitation that targeted the paralyzed side's upper limb in a hemiplegic stroke patient remarkably accelerated the patient's ability to perform activities of daily living, improved her Functional Independence Measure score, and facilitated the patient's return to home. [Subject and Methods] We provided rehabilitation training to a female patient who experienced a cerebral infarction at a nursing home for the elderly and was admitted to the Kaifukuki recovery phase rehabilitation ward in order to improve her activities of daily living and return home...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28603364/interrelationship-among-the-health-related-and-subjective-quality-of-life-daily-life-activities-instrumental-activities-of-daily-living-of-community-dwelling-elderly-females-in-orthopedic-outpatients
#19
Seiichi Takemasa, Ryoma Nakagoshi, Masayuki Uesugi, Yuri Inoue, Makoto Gotou, Susumu Naruse, Yoshihumi Nanba
[Purpose] This study aimed to examine the health-related and subjective quality of life of community-dwelling elderly females in orthopedic outpatients, and also examined how such quality of life correlate with their daily life activities and instrumental activities of daily living. [Subjects and Methods] Subjects were 27 community-dwelling elderly females in orthopedic outpatients (mean age: 76.3 ± 7.4 years). Their health-related quality of life and subjective quality of life, life-space assessment, frenchay activities index were researched...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28602617/objective-measures-of-activity-in-the-elderly-distribution-and-associations-with-demographic-and-health-factors
#20
Chantal M Koolhaas, Frank J A van Rooij, Josje D Schoufour, Magda Cepeda, Henning Tiemeier, Soren Brage, Oscar H Franco
BACKGROUND: Little is known about the distribution of activity over the full 24-hour spectrum in late old age and its association with demographic and health factors. Therefore, we aimed to evaluate the distribution of physical activity (PA), sedentary behavior, and sleep, and associated factors in the elderly population. METHODS: Our study included 1210 participants (51.9% women) aged 70-94 years [mean age 77.5 years, standard deviation (SD) 5.0] from the population-based Rotterdam Study...
June 8, 2017: Journal of the American Medical Directors Association
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