Arsène Mekinian, Eric Grignano, Thorsten Braun, Olivier Decaux, Eric Liozon, Nathalie Costedoat-Chalumeau, Jean-Emmanuel Kahn, Mohammed Hamidou, Sophie Park, Xavier Puéchal, Eric Toussirot, Géraldine Falgarone, David Launay, Nathalie Morel, Sébastien Trouiller, Alexis Mathian, Bruno Gombert, Yoland Schoindre, Bertrand Lioger, Benoit De Wazieres, Zahir Amoura, Anne-Laure Buchdaul, Sophie Georgin-Lavialle, Jérémie Dion, Serge Madaule, Loïc Raffray, Pascal Cathebras, Jean Charles Piette, Christian Rose, Jean Marc Ziza, Olivier Lortholary, Francois Montestruc, Mohammed Omouri, Guillaume Denis, Julien Rossignol, Stanislas Nimubona, Lionel Adès, Claude Gardin, Pierre Fenaux, Olivier Fain
OBJECTIVE: We describe myelodysplastic syndrome (MDS)-associated systemic inflammatory and autoimmune diseases (SIADs), their treatments and outcomes and the impact of SIADs on overall survival in a French multicentre retrospective study. METHODS: In this study, 123 patients with MDS and SIADs were analysed. RESULTS: Mean age was 70 years (s.d. 13) and the male:female ratio was 2. The SIADs were systemic vasculitis in 39 (32%) cases, CTD in 31 (25%) cases, inflammatory arthritis in 28 (23%) cases, a neutrophilic disorder in 12 (10%) cases and unclassified in 13 cases (11%)...
February 2016: Rheumatology