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Lucie Picchio, Vincent Legagneux, Stephane Deschamps, Yoan Renaud, Sabine Chauveau, Luc Paillard, Krzysztof Jagla
Steinert disease, or myotonic dystrophy type 1 (DM1), is a multisystemic disorder caused by toxic noncoding CUG repeat transcripts, leading to altered levels of two RNA binding factors, MBNL1 and CELF1. The contribution of CELF1 to DM1 phenotypes is controversial. Here, we show that the Drosophila CELF1 family member, Bru - 3, contributes to pathogenic muscle defects observed in a Drosophila model of DM1. Bru-3 displays predominantly cytoplasmic expression in muscles and its muscle-specific overexpression causes a range of phenotypes also observed in the fly DM1 model, including affected motility, fiber splitting, reduced myofiber length and altered myoblast fusion...
May 21, 2018: Disease Models & Mechanisms
Rahul Arvo Jonas, Ya Xing Wang, Hua Yang, Jian Jun Li, Liang Xu, Songhomitra Panda-Jonas, Jost Bruno Jonas
PURPOSE: To measure the distance between the optic disc center and the fovea (DFD) and to assess its associations. METHODS: The population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals aged 50+ years. The DFD was measured on fundus photographs. RESULTS: Readable fundus photographs were available for 2836 (81.8%) individuals. Mean DFD was 4.76 ± 0.34 mm (median: 4.74 mm; range: 3.76-6.53 mm). In multivariate analysis, longer DFD was associated with longer axial length (P<0...
2015: PloS One
Renée F A G de Bruijn, Jan Heeringa, Frank J Wolters, Oscar H Franco, Bruno H C Stricker, Albert Hofman, Peter J Koudstaal, M Arfan Ikram
IMPORTANCE: Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, longitudinal studies assessing the association between AF and dementia have shown inconsistent results. OBJECTIVE: To determine the effect of AF on the risk of developing dementia during 20 years of follow-up. DESIGN, SETTING, AND PARTICIPANTS: The association of prevalent and incident AF with incident dementia was assessed from July 6, 1989, to February 4, 2010, in 6514 dementia-free participants in the prospective population-based Rotterdam Study...
November 2015: JAMA Neurology
Laure Raymond, Bruno Francou, François Petit, Lucie Tosca, Audrey Briand-Suleau, Corinne Metay, Jelena Martinovic, Anne-Gaël Cordier, Alexandra Benachi, Dominique Pineau, Anne Guiochon-Mantel, Michel Goossens, Gérard Tachdjian, Sophie Brisset
We report the prenatal detection of a de novo unbalanced complex chromosomal rearrangement (CCR), in a fetus with growth delay and bilateral cataracts. Standard karyotype and FISH analyses on amniotic fluid revealed a complex de novo translocation, resulting in a 46,XY,t(1;12;14)(q42;q14;q32) karyotype. CGH-array showed a significant deletion of 387  kb at 12q14.3, at a distance of only 200-700 kb from the breakpoint at 12q14, which encompassed the HMGA2 gene and occurred de novo. Although 12q14 microdeletions are associated with growth delay in several reports in the literature, we present here the smallest deletion prenatally detected, and we detail the clinical description of the fetus...
November 2015: European Journal of Medical Genetics
M Pascual, D Alignani, A Vilas-Zornoza, J A Delgado, I Vázquez, R Malumbres, I Rodriguez, R Barriuso, M J Calasanz, B Paiva, X Agirre, F Prósper, F J Cervera-Paz
No abstract text is available yet for this article.
October 2016: Clinical Otolaryngology
Claudio Muneretto, Ottavio Alfieri, Bruno Mario Cesana, Gianluigi Bisleri, Michele De Bonis, Roberto Di Bartolomeo, Carlo Savini, Gianluca Folesani, Lorenzo Di Bacco, Manfredo Rambaldini, Juan Pablo Maureira, Francois Laborde, Maurizio Tespili, Alberto Repossini, Thierry Folliguet
OBJECTIVE: We sought to investigate the clinical outcomes of patients with isolated severe aortic stenosis and an intermediate- to high-risk profile treated by means of conventional surgery (surgical aortic valve replacement), sutureless valve implantation, or transcatheter aortic valve replacement in a multicenter evaluation. METHODS: Among 991 consecutive patients with isolated severe aortic stenosis and an intermediate- to high-risk profile (Society of Thoracic Surgeons score >4 and logistic European System for Cardiac Operative Risk Evaluation I >10), a propensity score analysis was performed on the basis of the therapeutic strategy: surgical aortic valve replacement (n = 204), sutureless valve implantation (n = 204), and transcatheter aortic valve replacement (n = 204)...
December 2015: Journal of Thoracic and Cardiovascular Surgery
Bruno Vincenzi, Chiara Cremolini, Andrea Sartore-Bianchi, Antonio Russo, Francesco Mannavola, Giuseppe Perrone, Francesco Pantano, Fotios Loupakis, Daniele Rossini, Elena Ongaro, Erica Bonazzina, Emanuela Dell'Aquila, Marco Imperatori, Alice Zoccoli, Giuseppe Bronte, Giovanna De Maglio, Gabriella Fontanini, Clara Natoli, Alfredo Falcone, Daniele Santini, Andrea Onetti-Muda, Salvatore Siena, Giuseppe Tonini, Giuseppe Aprile
INTRODUCTION: Activating mutations of K-Ras gene have a well-established role as predictors of resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (mCRC) patients. Their prognostic value is controversial, and no data regarding the prognostic value of mutation rate, defined as the percentage of mutated alleles/tumor sample, are available. We aimed to evaluate the prognostic value of K-Rasmutation rate in a homogenous cohort of mCRC patients receiving first-line doublet plus bevacizumab...
October 13, 2015: Oncotarget
Alisson L da Rocha, Bruno C Pereira, José R Pauli, Claudio T de Souza, Giovana R Teixeira, Fábio S Lira, Dennys E Cintra, Eduardo R Ropelle, Carlos R B Júnior, Adelino S R da Silva
The aim of this study was to verify the effects of running overtraining protocols performed in downhill, uphill, and without inclination on the proteins related to hypertrophy signaling pathway in extensor digitorum longus (EDL) and soleus of C57BL/6 mice. We also performed histological and stereological analyses. Rodents were divided into control (CT; sedentary mice), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up), and overtrained by running without inclination (OTR). The incremental load, exhaustive, and grip force tests were used as performance evaluation parameters...
May 2016: Journal of Cellular Physiology
Anja Scharinger, Stephanie Eckrich, David H Vandael, Kai Schönig, Alexandra Koschak, Dietmar Hecker, Gurjot Kaur, Amy Lee, Anupam Sah, Dusan Bartsch, Bruno Benedetti, Andreas Lieb, Bernhard Schick, Nicolas Singewald, Martina J Sinnegger-Brauns, Emilio Carbone, Jutta Engel, Jörg Striessnig
Cav1.3 L-type Ca(2+)-channel function is regulated by a C-terminal automodulatory domain (CTM). It affects channel binding of calmodulin and thereby tunes channel activity by interfering with Ca(2+)- and voltage-dependent gating. Alternative splicing generates short C-terminal channel variants lacking the CTM resulting in enhanced Ca(2+)-dependent inactivation and stronger voltage-sensitivity upon heterologous expression. However, the role of this modulatory domain for channel function in its native environment is unkown...
2015: Frontiers in Cellular Neuroscience
Jennifer K Cooper, Matthew Spencer, John F Bruno
Pressure on natural communities from human activities continues to increase. Even unique ecosystems like the Great Barrier Reef (GBR), that until recently were considered near-pristine and well-protected, are showing signs of rapid degradation. We collated recent (1996-2006) spatiotemporal relationships between benthic community composition on the GBR and environmental variables (ocean temperature and local threats resulting from human activity). We built multivariate models of the effects of these variables on short-term dynamics, and developed an analytical approach to study their long-term consequences...
July 2015: Ecology
Bruno Gomes, Craig S Wilding, David Weetman, Carla A Sousa, Maria T Novo, Harry M Savage, António P G Almeida, João Pinto, Martin J Donnelly
BACKGROUND: Divergent selection can be a major driver of ecological speciation. In insects of medical importance, understanding the speciation process is both of academic interest and public health importance. In the West Nile virus vector Culex pipiens, intraspecific pipiens and molestus forms vary in ecological and physiological traits. Populations of each form appear to share recent common ancestry but patterns of genetic differentiation across the genome remain unknown. Here, we undertook an AFLP genome scan on samples collected from both sympatric and allopatric populations from Europe and the USA to quantify the extent of genomic differentiation between the two forms...
2015: BMC Evolutionary Biology
F Dias de Castro, Pedro Boal Carvalho, Sara Monteiro, Bruno Rosa, João Firmino-Machado, Maria João Moreira, José Cotter
BACKGROUND AND AIMS: Small bowel capsule endoscopy (SBCE) allows mapping of small bowel inflammation in Crohn's disease (CD). We aimed to assess the prognostic value of the severity of inflammatory lesions, quantified by the Lewis score (LS), in patients with isolated small bowel CD. METHODS: A retrospective study was performed in which 53 patients with isolated small bowel CD were submitted to SBCE at the time of diagnosis. The Lewis score was calculated and patients had at least 12 months of follow-up after diagnosis...
December 2015: Journal of Crohn's & Colitis
Thomas Guery, Christophe Roumier, Celine Berthon, Aline Renneville, Claude Preudhomme, Bruno Quesnel
Costimulatory molecules are essential regulators of the immunological synapse and enable the fine-tuning of the immune response. These mechanisms are subverted by cancer cells to evade immunosurveillance. The B7 family of costimulatory molecules comprises several ligands that may contribute to immunoescape. B7-H3 [B7-homolog 3 or CD276] remains poorly investigated in hematological malignancies. To determine the role B7-H3, we analyzed the expression of this molecule in blast cells from a cohort of 111 acute myeloid leukemia (AML) patients...
December 2015: Cancer Medicine
Bruna Andrade E Silva, Ricardo C Cassilhas, Cecília Attux, Quirino Cordeiro, André L Gadelha, Bruno A Telles, Rodrigo A Bressan, Francine N Ferreira, Paulo H Rodstein, Claudiane S Daltio, Sérgio Tufik, Marco T de Mello
OBJECTIVE: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. METHODS: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9)...
October 2015: Revista Brasileira de Psiquiatria
Yannick Le Manach, Gary Collins, Mohit Bhandari, Amal Bessissow, Jacques Boddaert, Frédéric Khiami, Harman Chaudhry, Justin De Beer, Bruno Riou, Paul Landais, Mitchell Winemaker, Thierry Boudemaghe, P J Devereaux
IMPORTANCE: Patients undergoing surgery for a hip fracture have a higher risk of mortality and major complications compared with patients undergoing an elective total hip replacement (THR) operation. The effect of older age and comorbidities associated with hip fracture on this increased perioperative risk is unknown. OBJECTIVE: To determine if there was a difference in hospital mortality among patients who underwent hip fracture surgery relative to an elective THR, after adjustment for age, sex, and preoperative comorbidities...
September 15, 2015: JAMA: the Journal of the American Medical Association
Nicole Di Lascio, Vincenzo Gemignani, Rosa Maria Bruno, Elisabetta Bianchini, Francesco Stea, Lorenzo Ghiadoni, Francesco Faita
OBJECTIVE: Central pulse pressure (cPP) is increasingly investigated as possible independent predictor of cardiovascular risk and carotid pulse pressure (carPP) can be used as a surrogate of cPP. Despite its importance, carPP measurement remains challenging in clinical practice. The aim of this study was to introduce a new easier-to-use method for noninvasive carPP evaluation based on the use of a MEMS accelerometer. METHODS: carPP values (carPP(acc)) were obtained in 22 subjects (10 males, 47 ±17 years, hypertension: 50%) postprocessing and double integrating the accelerometric signals...
April 2016: IEEE Transactions on Bio-medical Engineering
Kangwei Xia, Roman Kolesov, Ya Wang, Petr Siyushev, Rolf Reuter, Thomas Kornher, Nadezhda Kukharchyk, Andreas D Wieck, Bruno Villa, Sen Yang, Jörg Wrachtrup
All-optical addressing and coherent control of single solid-state based quantum bits is a key tool for fast and precise control of ground-state spin qubits. So far, all-optical addressing of qubits was demonstrated only in a very few systems, such as color centers and quantum dots. Here, we perform high-resolution spectroscopic of native and implanted single rare earth ions in solid, namely, a cerium ion in yttrium aluminum garnet (YAG) crystal. We find narrow and spectrally stable optical transitions between the spin sublevels of the ground and excited optical states...
August 28, 2015: Physical Review Letters
Hirak Pahari, Wei-Feng Li, Tsan-Shiun Lin, Chih-Chi Wang, Chee-Chien Yong, Ting-Lung Lin, Chih-Che Lin, Yueh-Wei Liu, Yu-Hung Lin, Allan M Concejero, Bruno Jawan, Chao-Long Chen
BACKGROUND: Adhesions are abnormal fibrous bands of scar tissue between internal organs and tissues. With respect to recipient hepatectomy in living donor liver transplantation (LDLT), we defined extensive adhesions as adhesions in at least two separate locations that required more than 5 % of the total surgical time to lyse. We aimed to identify the etiology and consequences of this preventable burden. METHODS: A simple retrospective case-control study of all cases with extensive adhesions from August 2011 to September 2014 matched by age, sex, and diagnosis at surgery...
February 2016: World Journal of Surgery
Chris O Adedire, Joseph A Adeyemi, Ana Carolina Paulelli, Airton da Cunha Martins-Junior, Kayode D Ileke, Fabiana Roberta Segura, Vanessa C de Oliveira-Souza, Bruno L Batista, Fernando Barbosa
In this study, levels and estimated daily intake (EDI) of two toxic elements, Cd and Pb, and eight essential elements: Ca, P, Zn, Mn, Co, Cu, Se and Mo, were determined in Nigerian rice samples. The mean levels of Cd, Pb and Co were 5.43±0.88, 38.66±5.42, 25.8±3.18 ng/g. The mean levels of Ca, P, Zn, Mn, Cu, Se and Mo were 71.5±7.31, 951±52.0, 10.2±0.63, 8.5±0.47, 3.07±0.18, 40.1±9.2 and 0.39±0.05 µg/g, respectively. The percentage contribution to the reference values for each element was 0.54, 7...
2015: Food Additives & Contaminants. Part B, Surveillance
Mohammad H Forouzanfar, Lily Alexander, H Ross Anderson, Victoria F Bachman, Stan Biryukov, Michael Brauer, Richard Burnett, Daniel Casey, Matthew M Coates, Aaron Cohen, Kristen Delwiche, Kara Estep, Joseph J Frostad, K C Astha, Hmwe H Kyu, Maziar Moradi-Lakeh, Marie Ng, Erica Leigh Slepak, Bernadette A Thomas, Joseph Wagner, Gunn Marit Aasvang, Cristiana Abbafati, Ayse Abbasoglu Ozgoren, Foad Abd-Allah, Semaw F Abera, Victor Aboyans, Biju Abraham, Jerry Puthenpurakal Abraham, Ibrahim Abubakar, Niveen M E Abu-Rmeileh, Tania C Aburto, Tom Achoki, Ademola Adelekan, Koranteng Adofo, Arsène K Adou, José C Adsuar, Ashkan Afshin, Emilie E Agardh, Mazin J Al Khabouri, Faris H Al Lami, Sayed Saidul Alam, Deena Alasfoor, Mohammed I Albittar, Miguel A Alegretti, Alicia V Aleman, Zewdie A Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, Mohammed K Ali, François Alla, Peter Allebeck, Peter J Allen, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Adansi A Amankwaa, Azmeraw T Amare, Emmanuel A Ameh, Omid Ameli, Heresh Amini, Walid Ammar, Benjamin O Anderson, Carl Abelardo T Antonio, Palwasha Anwari, Solveig Argeseanu Cunningham, Johan Arnlöv, Valentina S Arsic Arsenijevic, Al Artaman, Rana J Asghar, Reza Assadi, Lydia S Atkins, Charles Atkinson, Marco A Avila, Baffour Awuah, Alaa Badawi, Maria C Bahit, Talal Bakfalouni, Kalpana Balakrishnan, Shivanthi Balalla, Ravi Kumar Balu, Amitava Banerjee, Ryan M Barber, Suzanne L Barker-Collo, Simon Barquera, Lars Barregard, Lope H Barrero, Tonatiuh Barrientos-Gutierrez, Ana C Basto-Abreu, Arindam Basu, Sanjay Basu, Mohammed O Basulaiman, Carolina Batis Ruvalcaba, Justin Beardsley, Neeraj Bedi, Tolesa Bekele, Michelle L Bell, Corina Benjet, Derrick A Bennett, Habib Benzian, Eduardo Bernabé, Tariku J Beyene, Neeraj Bhala, Ashish Bhalla, Zulfiqar A Bhutta, Boris Bikbov, Aref A Bin Abdulhak, Jed D Blore, Fiona M Blyth, Megan A Bohensky, Berrak Bora Başara, Guilherme Borges, Natan M Bornstein, Dipan Bose, Soufiane Boufous, Rupert R Bourne, Michael Brainin, Alexandra Brazinova, Nicholas J Breitborde, Hermann Brenner, Adam D M Briggs, David M Broday, Peter M Brooks, Nigel G Bruce, Traolach S Brugha, Bert Brunekreef, Rachelle Buchbinder, Linh N Bui, Gene Bukhman, Andrew G Bulloch, Michael Burch, Peter G J Burney, Ismael R Campos-Nonato, Julio C Campuzano, Alejandra J Cantoral, Jack Caravanos, Rosario Cárdenas, Elisabeth Cardis, David O Carpenter, Valeria Caso, Carlos A Castañeda-Orjuela, Ruben E Castro, Ferrán Catalá-López, Fiorella Cavalleri, Alanur Çavlin, Vineet K Chadha, Jung-Chen Chang, Fiona J Charlson, Honglei Chen, Wanqing Chen, Zhengming Chen, Peggy P Chiang, Odgerel Chimed-Ochir, Rajiv Chowdhury, Costas A Christophi, Ting-Wu Chuang, Sumeet S Chugh, Massimo Cirillo, Thomas K D Claßen, Valentina Colistro, Mercedes Colomar, Samantha M Colquhoun, Alejandra G Contreras, Cyrus Cooper, Kimberly Cooperrider, Leslie T Cooper, Josef Coresh, Karen J Courville, Michael H Criqui, Lucia Cuevas-Nasu, James Damsere-Derry, Hadi Danawi, Lalit Dandona, Rakhi Dandona, Paul I Dargan, Adrian Davis, Dragos V Davitoiu, Anand Dayama, E Filipa de Castro, Vanessa De la Cruz-Góngora, Diego De Leo, Graça de Lima, Louisa Degenhardt, Borja del Pozo-Cruz, Robert P Dellavalle, Kebede Deribe, Sarah Derrett, Don C Des Jarlais, Muluken Dessalegn, Gabrielle A deVeber, Karen M Devries, Samath D Dharmaratne, Mukesh K Dherani, Daniel Dicker, Eric L Ding, Klara Dokova, E Ray Dorsey, Tim R Driscoll, Leilei Duan, Adnan M Durrani, Beth E Ebel, Richard G Ellenbogen, Yousef M Elshrek, Matthias Endres, Sergey P Ermakov, Holly E Erskine, Babak Eshrati, Alireza Esteghamati, Saman Fahimi, Emerito Jose A Faraon, Farshad Farzadfar, Derek F J Fay, Valery L Feigin, Andrea B Feigl, Seyed-Mohammad Fereshtehnejad, Alize J Ferrari, Cleusa P Ferri, Abraham D Flaxman, Thomas D Fleming, Nataliya Foigt, Kyle J Foreman, Urbano Fra Paleo, Richard C Franklin, Belinda Gabbe, Lynne Gaffikin, Emmanuela Gakidou, Amiran Gamkrelidze, Fortuné G Gankpé, Ron T Gansevoort, Francisco A García-Guerra, Evariste Gasana, Johanna M Geleijnse, Bradford D Gessner, Pete Gething, Katherine B Gibney, Richard F Gillum, Ibrahim A M Ginawi, Maurice Giroud, Giorgia Giussani, Shifalika Goenka, Ketevan Goginashvili, Hector Gomez Dantes, Philimon Gona, Teresita Gonzalez de Cosio, Dinorah González-Castell, Carolyn C Gotay, Atsushi Goto, Hebe N Gouda, Richard L Guerrant, Harish C Gugnani, Francis Guillemin, David Gunnell, Rahul Gupta, Rajeev Gupta, Reyna A Gutiérrez, Nima Hafezi-Nejad, Holly Hagan, Maria Hagstromer, Yara A Halasa, Randah R Hamadeh, Mouhanad Hammami, Graeme J Hankey, Yuantao Hao, Hilda L Harb, Tilahun Nigatu Haregu, Josep Maria Haro, Rasmus Havmoeller, Simon I Hay, Mohammad T Hedayati, Ileana B Heredia-Pi, Lucia Hernandez, Kyle R Heuton, Pouria Heydarpour, Martha Hijar, Hans W Hoek, Howard J Hoffman, John C Hornberger, H Dean Hosgood, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Howard Hu, Cheng Huang, John J Huang, Bryan J Hubbell, Laetitia Huiart, Abdullatif Husseini, Marissa L Iannarone, Kim M Iburg, Bulat T Idrisov, Nayu Ikeda, Kaire Innos, Manami Inoue, Farhad Islami, Samaya Ismayilova, Kathryn H Jacobsen, Henrica A Jansen, Deborah L Jarvis, Simerjot K Jassal, Alejandra Jauregui, Sudha Jayaraman, Panniyammakal Jeemon, Paul N Jensen, Vivekanand Jha, Fan Jiang, Guohong Jiang, Ying Jiang, Jost B Jonas, Knud Juel, Haidong Kan, Sidibe S Kany Roseline, Nadim E Karam, André Karch, Corine K Karema, Ganesan Karthikeyan, Anil Kaul, Norito Kawakami, Dhruv S Kazi, Andrew H Kemp, Andre P Kengne, Andre Keren, Yousef S Khader, Shams Eldin Ali Hassan Khalifa, Ejaz A Khan, Young-Ho Khang, Shahab Khatibzadeh, Irma Khonelidze, Christian Kieling, Daniel Kim, Sungroul Kim, Yunjin Kim, Ruth W Kimokoti, Yohannes Kinfu, Jonas M Kinge, Brett M Kissela, Miia Kivipelto, Luke D Knibbs, Ann Kristin Knudsen, Yoshihiro Kokubo, M Rifat Kose, Soewarta Kosen, Alexander Kraemer, Michael Kravchenko, Sanjay Krishnaswami, Hans Kromhout, Tiffany Ku, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Ernst J Kuipers, Chanda Kulkarni, Veena S Kulkarni, G Anil Kumar, Gene F Kwan, Taavi Lai, Arjun Lakshmana Balaji, Ratilal Lalloo, Tea Lallukka, Hilton Lam, Qing Lan, Van C Lansingh, Heidi J Larson, Anders Larsson, Dennis O Laryea, Pablo M Lavados, Alicia E Lawrynowicz, Janet L Leasher, Jong-Tae Lee, James Leigh, Ricky Leung, Miriam Levi, Yichong Li, Yongmei Li, Juan Liang, Xiaofeng Liang, Stephen S Lim, M Patrice Lindsay, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Giancarlo Logroscino, Stephanie J London, Nancy Lopez, Joannie Lortet-Tieulent, Paulo A Lotufo, Rafael Lozano, Raimundas Lunevicius, Jixiang Ma, Stefan Ma, Vasco M P Machado, Michael F MacIntyre, Carlos Magis-Rodriguez, Abbas A Mahdi, Marek Majdan, Reza Malekzadeh, Srikanth Mangalam, Christopher C Mapoma, Marape Marape, Wagner Marcenes, David J Margolis, Christopher Margono, Guy B Marks, Randall V Martin, Melvin B Marzan, Mohammad T Mashal, Felix Masiye, Amanda J Mason-Jones, Kunihiro Matsushita, Richard Matzopoulos, Bongani M Mayosi, Tasara T Mazorodze, Abigail C McKay, Martin McKee, Abigail McLain, Peter A Meaney, Catalina Medina, Man Mohan Mehndiratta, Fabiola Mejia-Rodriguez, Wubegzier Mekonnen, Yohannes A Melaku, Michele Meltzer, Ziad A Memish, Walter Mendoza, George A Mensah, Atte Meretoja, Francis Apolinary Mhimbira, Renata Micha, Ted R Miller, Edward J Mills, Awoke Misganaw, Santosh Mishra, Norlinah Mohamed Ibrahim, Karzan A Mohammad, Ali H Mokdad, Glen L Mola, Lorenzo Monasta, Julio C Montañez Hernandez, Marcella Montico, Ami R Moore, Lidia Morawska, Rintaro Mori, Joanna Moschandreas, Wilkister N Moturi, Dariush Mozaffarian, Ulrich O Mueller, Mitsuru Mukaigawara, Erin C Mullany, Kinnari S Murthy, Mohsen Naghavi, Ziad Nahas, Aliya Naheed, Kovin S Naidoo, Luigi Naldi, Devina Nand, Vinay Nangia, K M Venkat Narayan, Denis Nash, Bruce Neal, Chakib Nejjari, Sudan P Neupane, Charles R Newton, Frida N Ngalesoni, Jean de Dieu Ngirabega, Grant Nguyen, Nhung T Nguyen, Mark J Nieuwenhuijsen, Muhammad I Nisar, José R Nogueira, Joan M Nolla, Sandra Nolte, Ole F Norheim, Rosana E Norman, Bo Norrving, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Bolajoko O Olusanya, Saad B Omer, John Nelson Opio, Ricardo Orozco, Rodolfo S Pagcatipunan, Amanda W Pain, Jeyaraj D Pandian, Carlo Irwin A Panelo, Christina Papachristou, Eun-Kee Park, Charles D Parry, Angel J Paternina Caicedo, Scott B Patten, Vinod K Paul, Boris I Pavlin, Neil Pearce, Lilia S Pedraza, Andrea Pedroza, Ljiljana Pejin Stokic, Ayfer Pekericli, David M Pereira, Rogelio Perez-Padilla, Fernando Perez-Ruiz, Norberto Perico, Samuel A L Perry, Aslam Pervaiz, Konrad Pesudovs, Carrie B Peterson, Max Petzold, Michael R Phillips, Hwee Pin Phua, Dietrich Plass, Dan Poenaru, Guilherme V Polanczyk, Suzanne Polinder, Constance D Pond, C Arden Pope, Daniel Pope, Svetlana Popova, Farshad Pourmalek, John Powles, Dorairaj Prabhakaran, Noela M Prasad, Dima M Qato, Amado D Quezada, D Alex A Quistberg, Lionel Racapé, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Murugesan Raju, Ivo Rakovac, Saleem M Rana, Mayuree Rao, Homie Razavi, K Srinath Reddy, Amany H Refaat, Jürgen Rehm, Giuseppe Remuzzi, Antonio L Ribeiro, Patricia M Riccio, Lee Richardson, Anne Riederer, Margaret Robinson, Anna Roca, Alina Rodriguez, David Rojas-Rueda, Isabelle Romieu, Luca Ronfani, Robin Room, Nobhojit Roy, George M Ruhago, Lesley Rushton, Nsanzimana Sabin, Ralph L Sacco, Sukanta Saha, Ramesh Sahathevan, Mohammad Ali Sahraian, Joshua A Salomon, Deborah Salvo, Uchechukwu K Sampson, Juan R Sanabria, Luz Maria Sanchez, Tania G Sánchez-Pimienta, Lidia Sanchez-Riera, Logan Sandar, Itamar S Santos, Amir Sapkota, Maheswar Satpathy, James E Saunders, Monika Sawhney, Mete I Saylan, Peter Scarborough, Jürgen C Schmidt, Ione J C Schneider, Ben Schöttker, David C Schwebel, James G Scott, Soraya Seedat, Sadaf G Sepanlou, Berrin Serdar, Edson E Servan-Mori, Gavin Shaddick, Saeid Shahraz, Teresa Shamah Levy, Siyi Shangguan, Jun She, Sara Sheikhbahaei, Kenji Shibuya, Hwashin H Shin, Yukito Shinohara, Rahman Shiri, Kawkab Shishani, Ivy Shiue, Inga D Sigfusdottir, Donald H Silberberg, Edgar P Simard, Shireen Sindi, Abhishek Singh, Gitanjali M Singh, Jasvinder A Singh, Vegard Skirbekk, Karen Sliwa, Michael Soljak, Samir Soneji, Kjetil Søreide, Sergey Soshnikov, Luciano A Sposato, Chandrashekhar T Sreeramareddy, Nicolas J C Stapelberg, Vasiliki Stathopoulou, Nadine Steckling, Dan J Stein, Murray B Stein, Natalie Stephens, Heidi Stöckl, Kurt Straif, Konstantinos Stroumpoulis, Lela Sturua, Bruno F Sunguya, Soumya Swaminathan, Mamta Swaroop, Bryan L Sykes, Karen M Tabb, Ken Takahashi, Roberto T Talongwa, Nikhil Tandon, David Tanne, Marcel Tanner, Mohammad Tavakkoli, Braden J Te Ao, Carolina M Teixeira, Martha M Téllez Rojo, Abdullah S Terkawi, José Luis Texcalac-Sangrador, Sarah V Thackway, Blake Thomson, Andrew L Thorne-Lyman, Amanda G Thrift, George D Thurston, Taavi Tillmann, Myriam Tobollik, Marcello Tonelli, Fotis Topouzis, Jeffrey A Towbin, Hideaki Toyoshima, Jefferson Traebert, Bach X Tran, Leonardo Trasande, Matias Trillini, Ulises Trujillo, Zacharie Tsala Dimbuene, Miltiadis Tsilimbaris, Emin Murat Tuzcu, Uche S Uchendu, Kingsley N Ukwaja, Selen B Uzun, Steven van de Vijver, Rita Van Dingenen, Coen H van Gool, Jim van Os, Yuri Y Varakin, Tommi J Vasankari, Ana Maria N Vasconcelos, Monica S Vavilala, Lennert J Veerman, Gustavo Velasquez-Melendez, N Venketasubramanian, Lakshmi Vijayakumar, Salvador Villalpando, Francesco S Violante, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Gregory R Wagner, Stephen G Waller, Mitchell T Wallin, Xia Wan, Haidong Wang, JianLi Wang, Linhong Wang, Wenzhi Wang, Yanping Wang, Tati S Warouw, Charlotte H Watts, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, K Ryan Wessells, Ronny Westerman, Harvey A Whiteford, James D Wilkinson, Hywel C Williams, Thomas N Williams, Solomon M Woldeyohannes, Charles D A Wolfe, John Q Wong, Anthony D Woolf, Jonathan L Wright, Brittany Wurtz, Gelin Xu, Lijing L Yan, Gonghuan Yang, Yuichiro Yano, Pengpeng Ye, Muluken Yenesew, Gökalp K Yentür, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Zourkaleini Younoussi, Chuanhua Yu, Maysaa E Zaki, Yong Zhao, Yingfeng Zheng, Maigeng Zhou, Jun Zhu, Shankuan Zhu, Xiaonong Zou, Joseph R Zunt, Alan D Lopez, Theo Vos, Christopher J Murray
BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution...
December 5, 2015: Lancet
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