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https://www.readbyqxmd.com/read/30007179/discovery-of-quality-control-markers-from-traditional-chinese-medicines-by-fingerprint-efficacy-modeling-current-status-and-future-perspectives
#1
REVIEW
Cai Zhang, Xian Zheng, Hui Ni, Ping Li, Hui-Jun Li
Quality control (QC) is crucial for ensuring the safety and effectiveness of traditional Chinese medicines (TCMs). Due to extremely complicated phytochemical matrices and characteristic mode of "multi-component, multi-target, integrated adjustment", discovering of QC markers from TCMs is a big challenge. Fingerprint-efficacy (FE) modeling method is currently proposed as an effective and reasonable attempt. This review summarizes the methodologies of FE modeling and applications in screening QC markers, meanwhile the future perspectives are also briefly discussed so as to provide inspiration and reference for follow-up study of FE relationship for TCMs...
July 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30007052/establishment-and-application-of-a-new-hplc-qualitative-and-quantitative-assay-for-gentiana-macrophyllae-radix-based-on-characteristic-constituents-of-anofinic-acid-and-its-derivatives
#2
Wenzheng Ding, Hanxue Wang, Quan Zhou, Jinrong Wu, Xuemei Cheng, Changhong Wang
Gentiana macrophylla Radix (GMR) is officially used as traditional Chinese medicine, but easily confused with Gentianae radix et rhizoma (GRR) and adulterants. The paper aims to establish a HPLC method for qualitative and quantitative analysis of GMR based on characteristic components, anofinic acid and its derivatives. HPLC analysis was performed on a C18 column with gradient elution using acetonitrile and 0.1% phosphoric acid as mobile phase, and detected at 240 nm, by conventional methodology validation...
July 14, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30006090/aporphine-alkaloids-from-illigera-aromatica-from-guangxi-province-china
#3
Yi-Chao Ge, Hai-Jiang Zhang, Kui-Wu Wang, Xin-Feng Fan
Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (1 H, 13 C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32...
July 6, 2018: Phytochemistry
https://www.readbyqxmd.com/read/30005720/development-of-a-method-for-simultaneous-determination-of-two-stilbenes-and-four-anthraquinones-from-polygonum-cuspidatum-by-rp-hplc
#4
Jianye Yan, Yuanqing Wang, Hongnian Wu, Zhicheng Sun, Shihan Tan, Wei Wang, Limin Gong, Xinhua Xia, Shunxiang Li
Background : Polygonum cuspidatum Sieb. et Zucc. (named Huzhang in China) is a traditional and popular Chinese medicinal herb used in removing jaundice, clearing heat-toxin, improving blood circulation, expelling stasis, dispelling wind and dampness, repelling phlegm, and suppressing cough. It is widely used in drug and functional food fields and distributed throughout the world, including in China, Japan, and North America. Objective : To control the quality of Polygonum cuspidatum , an effective, reliable, and simple method for simultaneous determination of two stilbenes (polydatin, resveratrol) and four anthraquinones (emodin, physcion, rhein, and anthraglycoside B) was developed and validated for the first time in this study by reversed-phase HPLC (RP-HPLC)...
July 13, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/30005428/rapid-and-simultaneous-determination-of-three-active-components-in-raw-and-processed-root-samples-of-scutellaria-baicalensis-by-near-infrared-spectroscopy
#5
Xue Jintao, Yang Quanwei, Li Chunyan, Jing Yun, Wang Shuangxi, Zhang Mingxiang, Li Peng
Motivated by the wide use of Scutellariae Radix (SR) in the food and pharmaceutical industries, a rapid and non-destructive near-infrared spectroscopy (NIRS) method was developed for the simultaneous analysis of three main active components in raw SR and SR processed by stir-frying with wine. From seven geographical areas, 58 samples were collected. The reference contents for the SR components baicalin, baicalein, and wogonin were determined by high-performance liquid chromatography. Two multivariate analysis methods, partial least-squares (PLS) regression as a linear regression method and artificial neural networks (ANN) as a nonlinear regression method, were applied to the NIR data, and their results were compared...
July 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/30003570/quality-evaluation-for-radix-astragali-based-on-fingerprint-indicative-components-selection-and-qams
#6
Jun Huang, Lei Yin, Lin Dong, Hongfeng Quan, Rong Chen, Shiyao Hua, Jiahua Ma, Dongyan Guo, Xueyan Fu
Radix astragali (RA) is one of the most widely used Chinese herbs prescribed in many Chinese formulas to reinforce 'Qi' and treat vital energy deficiency. This study combined fingerprint with quantitative analysis multi-components by a single marker (QAMS) to improve the quality control standard for RA on the basis of existing quality control methods of traditional Chinese medicinal materials. UPLC-ESI-TOF-MS technique was used to evaluate the quality of RA by fingerprint and QAMS. Through the anti-inflammatory, anti-oxidation and anti-anoxic activities to screen characteristic components of RA, the CG, ononin, astragaloside IV, astragaloside II, calycosin and astrageloside I significantly inhibited ear edema in mice, the calycosin and CG had good antioxidant activity, the astragaloside I had a significant anti-hypoxia activity...
July 12, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30003114/hei-gu-teng-zhuifenghuoluo-granule-modulates-il-12-signal-pathway-to-inhibit-the-inflammatory-response-in-rheumatoid-arthritis
#7
Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu
Rheumatoid arthritis (RA) is a type of chronic systemic inflammatory disease; it has a very complicated pathogenesis, and multiple pathological changes are implicated. Traditional Chinese medicine (TCM) like Tripterygium wilfordii Hook. F. or Sinomenium acutum (Thunb.) Rehd et Wils. has been extensively used for centuries in the treatment of arthritic diseases and been reported effective for relieving the severity of RA. Hei-Gu-Teng Zhuifenghuoluo granule (HGT) which contains Periploca forrestii Schltr. , Sinomenium acutum (Thunb...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30002726/-siegesbeckia-pubescens-makino-inhibits-pam-3-csk-4-induced-inflammation-in-raw-264-7-macrophages-through-suppressing-tlr1-tlr2-mediated-nf-%C3%AE%C2%BAb-activation
#8
Wei Sang, Zhangfeng Zhong, Kegang Linghu, Wei Xiong, Anfernee Kai Wing Tse, Wai San Cheang, Hua Yu, Yitao Wang
Background: Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory effects of SP were associated with the toll-like receptors (TLRs)-mediated nuclear factor-κB (NF-κB) and the mitogen-activated protein kinase (MAPK) signaling pathways. Methods: Raw 264.7 macrophages were pretreated with the 50% ethanol extract of SP (SPE, 50-200 µg/mL) and then co-treated with Pam3 CSK4 (200 ng/mL) for another 12 h...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/30002628/screening-of-combinatorial-quality-markers-for-natural-products-by-metabolomics-coupled-with-chemometrics-a-case-study-on-pollen-typhae
#9
Mingya Ding, Yan Jiang, Xiean Yu, Dong Zhang, Jin Li, Hui Wang, Jiayuan Shen, Xiu-Mei Gao, Yan-Xu Chang
Natural products, especially for traditional Chinese medicines (TCMs), are of great importance to cure diseases. Yet it was hard to screen the influential quality markers for monitoring the quality. A simple and comprehensive strategy was developed and validated to screen for the combinatorial quality markers for precise quality evaluation and discrimination of natural products. In this study, Pollen Typhae (PT) and it's processed products carbonized PT were selected as the representative case. Firstly, metabolomics data of 49 batches crude PT and carbonized PT was obtained by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30001642/chinese-herbal-medicine-for-advanced-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#10
Xia-Wei Zhang, Wei Liu, Hong-Li Jiang, Bing Mao
Chinese herbal medicine (CHM) has been widely used in the treatment of advanced non-small-cell lung cancer (NSCLC), but their efficacy and safety remain controversial. We sought to comprehensively aggregate and evaluate the available evidence on the efficacy and safety of the combination treatment with CHM and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in NSCLC patients. Our exhausted and systematical searching strategy yielded 64 related randomized controlled trials involving 4384 patients...
July 12, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/30001586/fate-of-antibiotic-resistance-genes-and-mobile-genetic-elements-during-anaerobic-co-digestion-of-chinese-medicinal-herbal-residues-and-swine-manure
#11
Li Zhang, Jie Gu, Xiaojuan Wang, Ranran Zhang, Xiaxia Tuo, Aiyun Guo, Ling Qiu
Swine manure is an important reservoir for antibiotic resistance genes (ARGs) but anaerobic co-digestion (AcoD) can potentially reduce the abundance of these ARGs. However, few studies have considered the effects of Chinese medicinal herbal residues (CMHRs) on the variations in ARGs and mobile genetic elements (MGEs) during AcoD. Thus, this study explored the fate of ARGs and MGEs during the AcoD of CMHRs and swine manure. The results showed that CMHRs effectively reduced the abundances of the main ARGs (excluding ermF, qnrA, and tetW) and four MGEs (by 36...
February 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29998928/-chinese-journal-of-nuclear-medicine-and-molecular-imaging-volume-38-number-6-june-25-2018
#12
(no author information available yet)
No abstract text is available yet for this article.
2018: Kaku Igaku. the Japanese Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29998893/effects-of-dandelion-extract-on-the-proliferation-of-rat-skeletal-muscle-cells-and-the-inhibition-of-a-lipopolysaccharide-induced-inflammatory-reaction
#13
Qiang Liu, Heng Zhao, Yue Gao, Yan Meng, Xiang-Xuan Zhao, Shi-Nong Pan
Background: Dandelion is commonly used in traditional Chinese medicine with several active compounds found in extracts. It has a variety of pharmacological effects, such as a reduction in swelling and inflammation, and detoxification. The mechanism by which dandelion extract inhibits the inflammatory response in skeletal muscle cells remains unknown; therefore, the aim of this study was to investigate the effects of dandelion extract root on the proliferation of skeletal muscle cells and the alleviation of lipopolysaccharide (LPS)-induced inflammatory response in vitro...
July 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29997930/evaluating-and-assessing-the-prevalence-of-bedside-ultrasound-in-emergency-departments-in-china
#14
Di Shi, Joseph H Walline, Xuezhong Yu, Jun Xu, Priscilla P Song, Huadong Zhu
Background: To survey the prevalence of bedside ultrasound assessment in emergency departments (EDs) in China. Methods: We designed an online survey for emergency physicians based in the China. The questionnaire included sixteen items querying common ED bedside ultrasound practices. Respondents were recruited via weblinks sent through social media and a popular Chinese emergency medicine website. Survey data was collected from April through June, 2016. Results: Four hundred and twenty-eight physicians responded to this survey; more than 80% of respondents reported working clinically in the ED...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997685/combination-of-salvia-miltiorrhiza-and-ligustrazine-attenuates-bleomycin-induced-pulmonary-fibrosis-in-rats-via-modulating-tnf-%C3%AE-and-tgf-%C3%AE
#15
Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang, Xianming Fan
Background: Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects. Recently, combination of two Chinese herbal medicine preparations, Salvia miltiorrhiza and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29997684/anticancer-drug-discovery-from-chinese-medicinal-herbs
#16
REVIEW
Mu-Yang Huang, Le-Le Zhang, Jian Ding, Jin-Jian Lu
Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as targeted therapy and immunotherapy. Chinese medicinal herbs have attracted considerable attention due to their potential anticancer effects. Some natural products or formulae from Chinese medicinal herbs with directly or indirectly anticancer effects have been reported. In this article, we summarized the current progression on development of anticancer drugs from Chinese medicinal herbs, toward providing ideas for further development and application of Chinese medicinal herbs in cancer therapy...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29997504/saponins-from-paris-forrestii-takht-h-li-display-potent-activity-against-acute-myeloid-leukemia-by-suppressing-the-rnf6-akt-mtor-signaling-pathway
#17
Qin Lu, Yuanming He, Yuehu Wang, Li Gao, Yunjing Zheng, Zubin Zhang, Biyin Cao, Qi Wang, Xinliang Mao, Shaoyan Hu
Saponins are amphipathic glycosides found in traditional Chinese medicines. In the present study, we isolated a panel of saponins from Paris forrestii (Takht.) H. Li, a unique plant found in Tibet and Yunnan provinces, China. By examining their activities in suppressing acute myeloid leukemia (AML) cell proliferation, total saponins from Paris forrestii (TSPf) displayed more potent activity than individual ones. TSPf induced more than 40% AML cell apoptosis and decreased the viability of all leukemia cell lines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29997503/a-computational-systems-pharmacology-approach-to-investigate-molecular-mechanisms-of-herbal-formula-tian-ma-gou-teng-yin-for-treatment-of-alzheimer-s-disease
#18
Tianduanyi Wang, Zengrui Wu, Lixia Sun, Weihua Li, Guixia Liu, Yun Tang
Traditional Chinese medicine (TCM) is typically prescribed as formula to treat certain symptoms. A TCM formula contains hundreds of chemical components, which makes it complicated to elucidate the molecular mechanisms of TCM. Here, we proposed a computational systems pharmacology approach consisting of network link prediction, statistical analysis, and bioinformatics tools to investigate the molecular mechanisms of TCM formulae. Taking formula Tian-Ma-Gou-Teng-Yin as an example, which shows pharmacological effects on Alzheimer's disease (AD) and its mechanism is unclear, we first identified 494 formula components together with corresponding 178 known targets, and then predicted 364 potential targets for these components with our balanced substructure-drug-target network-based inference method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29997360/ultra-liquid-chromatography-tandem-mass-spectrometry-uplc-ms-ms-based-pharmacokinetics-and-tissue-distribution-study-of-koumine-and-the-detoxification-mechanism-of-glycyrrhiza-uralensis-fisch-on-gelsemium-elegans-benth
#19
Lin Wang, Qi Sun, Nan Zhao, Yan-Qing Wen, Yang Song, Fan-Hao Meng
Gelsemium elegans Benth. ( G. elegans ), which is a famous Chinese folk medicine, has been commonly used to treat certain types of skin ulcers and alleviate inflammation, headaches, and cancer pain. However, the extensive clinical use of G. elegans has been greatly hampered by its toxicity. As one of the most widely used herbal medicines, Glycyrrhiza uralensis Fisch, has a unique effect on detoxification of G. elegans . In the present study, a rapid and sensitive method using ultra-liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was established and validated for determination of koumine, the most abundant molecule among the alkaloids of G...
July 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29996882/efficacy-and-indication-optimization-of-chinese-medicine-tiao-chang-ke-min-granules-for-diarrhea-predominant-irritable-bowel-syndrome-study-protocol-for-a-randomized-controlled-trial
#20
Qian Li, Bei-Ping Zhang, Shao-Gang Huang, Wen-Wei Ouyang, Jian-Hui Xie, Ze-Huai Wen, Xiao-Bo Yang
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic, recurring condition, prevalent in the general population. Current medication treatments usually leave patients undertreated. Nowadays, Chinese medicine (CM) is being considered as a promising treatment approach for IBS. However, due to methodological limitations, there is no strong evidence to support CM. Although IBS relapses are common, the relapse assessment has always been neglected in CM study designs. Meanwhile, in clinical practice and studies, it has been found that certain CM formulas can only benefit certain kinds of patients...
July 11, 2018: Trials
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