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https://www.readbyqxmd.com/read/29345255/pure-mechanistic-analysis-of-additive-neuroprotective-effects-between-baicalin-and-jasminoidin-in-ischemic-stroke-mice
#1
Peng-Qian Wang, Qiong Liu, Wen-Juan Xu, Ya-Nan Yu, Ying-Ying Zhang, Bing Li, Jun Liu, Zhong Wang
Both baicalin (BA) and jasminoidin (JA) are active ingredients in Chinese herb medicine Scutellaria baicalensis and Fructus gardeniae, respectively. They have been shown to exert additive neuroprotective action in ischemic stroke models. In this study we used transcriptome analysis to explore the pure therapeutic mechanisms of BA, JA and their combination (BJ) contributing to phenotype variation and reversal of pathological processes. Mice with middle cerebral artery obstruction were treated with BA, JA, their combination (BJ), or concha margaritifera (CM)...
January 18, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29345053/naringenin-4-5-7-trihydroxyflavanone-suppresses-the-development-of-precancerous-lesions-via-controlling-hyperproliferation-and-inflammation-in-the-colon-of-wistar-rats
#2
Muneeb U Rehman, Manzoor Ur Rahman Mir, Adil Farooq, Shahzada Mudasir Rashid, Bilal Ahmad, Sheikh Bilal Ahmad, Rayeesa Ali, Ishraq Hussain, Mubashir Masoodi, Showkeen Muzamil, Hassan Madkhali, Majid Ahmad Ganaie
Colon cancer is a world-wide health problem and one of the most dangerous type of cancer, affecting both men and women. Naringenin (4, 5, 7-trihydroxyflavanone) is one of the major flavone glycoside present in citrus fruits. Naringenin has long been used in Chinese's traditional medicine because of its exceptional pharmacological properties and non-toxic nature. In the present study, we investigated the chemopreventive potential of Naringenin against 1,2-dimethyhydrazine (DMH)-induced precancerous lesions, that is, aberrant crypt foci (ACF) and mucin depleted foci (MDF), and its role in regulating the oxidative stress, inflammation and hyperproliferation, in the colon of Wistar rats...
January 18, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29344655/protective-effects-of-osthole-against-inflammation-induced-by-lipopolysaccharide-in-bv2-cells
#3
Yuxin Bao, Xiaolin Meng, Fangning Liu, Fei Wang, Jinhui Yang, Haiyu Wang, Guanghong Xie
Inflammation and oxidative stress are implicated in the development of neurodegenerative diseases. Osthole is a compound that is extracted from She Chuang Zi, which is a type of traditional Chinese medicine. Osthole has previously been demonstrated to exhibit anticancer activities and has a low toxicity. However, to the best of our knowledge, the anti‑inflammatory effects of osthole in microglial cells have not been investigated extensively. The aim of the present study was to investigate the potential protective effects of osthole against inflammation induced by lipopolysaccharide (LPS) in microglial cells...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344421/anti-aging-implications-of-astragalus-membranaceus-huangqi-a-well-known-chinese-tonic
#4
REVIEW
Ping Liu, Haiping Zhao, Yumin Luo
Owing to a dramatic increase in average life expectancy and the Family Planning program of the 1970s - 1990s, China is rapidly becoming an aging society. Therefore, the investigation of healthspan-extending drugs becomes more urgent. Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344419/dendrobium-sources-of-active-ingredients-to-treat-age-related-pathologies
#5
REVIEW
Veronika Cakova, Frederic Bonte, Annelise Lobstein
Dendrobium represents one of the most important orchid genera, ornamentally and medicinally. Dendrobiums are sympodial epiphytic plants, which is a name they are worthy of, the name coming from Greek origin: "dendros", tree, and "bios", life. Dendrobium species have been used for a thousand years as first-rate herbs in traditional Chinese medicine (TCM). They are source of tonic, astringent, analgesic, antipyretic, and anti-inflammatory substances, and have been traditionally used as medicinal herbs in the treatment of a variety of disorders, such as, nourishing the stomach, enhancing production of body fluids or nourishing Yin...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344417/the-effect-of-traditional-chinese-medicine-on-neural-stem-cell-proliferation-and-differentiation
#6
REVIEW
Wei Qin, Shiya Chen, Shasha Yang, Qian Xu, Chuanshan Xu, Jing Cai
Neural stem cells (NSCs) are special types of cells with the potential for self-renewal and multi-directional differentiation. NSCs are regulated by multiple pathways and pathway related transcription factors during the process of proliferation and differentiation. Numerous studies have shown that the compound medicinal preparations, single herbs, and herb extracts in traditional Chinese medicine (TCM) have specific roles in regulating the proliferation and differentiation of NSCs. In this study, we investigate the markers of NSCs in various stages of differentiation, the related pathways regulating the proliferation and differentiation, and the corresponding transcription factors in the pathways...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344416/lycium-barbarum-a-traditional-chinese-herb-and-a-promising-anti-aging-agent
#7
REVIEW
Yanjie Gao, Yifo Wei, Yuqing Wang, Fang Gao, Zhigang Chen
Lycium barbarum has been used in China for more than 2,000 years as a traditional medicinal herb and food supplement. Lycium barbarum contains abundant Lycium barbarum polysaccharides (LBPs), betaine, phenolics, carotenoids (zeaxanthin and β-carotene), cerebroside, 2-O-β-d-glucopyranosyl-l-ascorbic acid (AA-2βG), β-sitosterol, flavonoids and vitamins (in particular, riboflavin, thiamine, and ascorbic acid). LBPs are the primary active components of Lycium barbarum. In this review, we discuss the pharmacological activities of LBPs and other major components...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344415/rhizoma-coptidis-and-berberine-as-a-natural-drug-to-combat-aging-and-aging-related-diseases-via-anti-oxidation-and-ampk-activation
#8
REVIEW
Zhifang Xu, Wei Feng, Qian Shen, Nannan Yu, Kun Yu, Shenjun Wang, Zhigang Chen, Seiji Shioda, Yi Guo
Aging is the greatest risk factor for human diseases, as it results in cellular growth arrest, impaired tissue function and metabolism, ultimately impacting life span. Two different mechanisms are thought to be primary causes of aging. One is cumulative DNA damage induced by a perpetuating cycle of oxidative stress; the other is nutrient-sensing adenosine monophosphate-activated protein kinase (AMPK) and rapamycin (mTOR)/ ribosomal protein S6 (rpS6) pathways. As the main bioactive component of natural Chinese medicine rhizoma coptidis (RC), berberine has recently been reported to expand life span in Drosophila melanogaster, and attenuate premature cellular senescence...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344414/herba-cistanches-anti-aging
#9
REVIEW
Ningqun Wang, Shaozhen Ji, Hao Zhang, Shanshan Mei, Lumin Qiao, Xianglan Jin
The Cistanche species ("Rou Cong Rong" in Chinese) is an endangered wild species growing in arid or semi-arid areas. The dried fleshy stem of Cistanches has been used as a tonic in China for many years. Modern pharmacological studies have since demonstrated that Herba Cistanches possesses broad medicinal functions, especially for use in anti-senescence, anti-oxidation, neuroprotection, anti-inflammation, hepatoprotection, immunomodulation, anti-neoplastic, anti-osteoporosis and the promotion of bone formation...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344413/therapeutic-potential-and-cellular-mechanisms-of-panax-notoginseng-on-prevention-of-aging-and-cell-senescence-associated-diseases
#10
REVIEW
Haiping Zhao, Ziping Han, Guangwen Li, Sijia Zhang, Yumin Luo
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. Panax notoginseng (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. Panax notoginseng has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344412/ginseng-an-nonnegligible-natural-remedy-for-healthy-aging
#11
REVIEW
Yong Yang, Changhong Ren, Yuan Zhang, XiaoDan Wu
Aging is an irreversible physiological process that affects all humans. Numerous theories have been proposed to regarding the process from a Western medicine perspective; however, ancient Chinese medicine practices and theories have increasingly gained attention, particularly ginseng, a grass that has been studied for the anti-aging properties of its active constituents. This review seeks to analyze current data on ginseng and its anti-aging properties. The plant species, characteristics, and active ingredients will be introduced...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344410/traditional-chinese-medicine-and-aging-intervention
#12
EDITORIAL
Haiping Zhao, Yumin Luo
No abstract text is available yet for this article.
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344262/hedyotis-diffusa-willd-extract-suppresses-colorectal-cancer-growth-through-multiple-cellular-pathways
#13
Jianyu Feng, Yiyi Jin, Jun Peng, Lihui Wei, Qiaoyan Cai, Zhaokun Yan, Zijun Lai, Jiumao Lin
The development of colorectal cancer (CRC) is strongly associated with the imbalance of various intracellular signal transduction cascades, including protein kinase B (AKT), mitogen-activated protein kinase 1 (MAPK), signal transducer and activator of transcription 3 (STAT3), as well as crosstalk between these signaling networks. At present, anti-tumor agents are often single-targeted and therefore are not always therapeutically effective. Moreover, long-term use of these anti-tumor agents often generates drug resistance and potential side effects...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344256/pien-tze-huang-inhibits-the-growth-of-hepatocellular-carcinoma-cells-by-upregulating-mir-16-expression
#14
Fei Qi, Songqiang Zhou, Li Li, Lihui Wei, Aling Shen, Liya Liu, Yaodong Wang, Jun Peng
Hepatocellular carcinoma (HCC) is characterized by uncontrolled proliferation and the deregulation of apoptotic signaling, although its molecular pathogenesis is not fully characterized. The ability to inhibit excessive proliferation and induce the apoptosis of cancer cells are crucial characteristics of anticancer drugs. Pien Tze Huang (PZH) is a widely used traditional Chinese medicine for the treatment of various types of cancer, and has exhibited promising therapeutic effects in clinical trials of HCC. However, the underlying mechanisms for its action are unclear...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344237/chloroform-extract-of-hedyotis-diffusa-willd-inhibits-viability-of-human-colorectal-cancer-cells-via-suppression-of-akt-and-erk-signaling-pathways
#15
Zhaokun Yan, Jianyu Feng, Jun Peng, Zijun Lai, Ling Zhang, Yiyi Jin, Hong Yang, Wujin Chen, Jiumao Lin
Hedyotis diffusa Willd (HDW) is a widely used traditional Chinese medicine in clinical therapy to treat various types of cancer, including colorectal cancer (CRC), but its effective polar fractions and functional mechanisms remain unclear. The aim of the present study was to determine the most effective extract of HDW and to investigate its effects on the regulation of CRC cell proliferation and apoptosis, as well as to investigate the underlying molecular mechanisms. The results demonstrated that the chloroform extract of HDW (CEHDW) exhibited the most anticancer ability...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343681/oral-health-in-china-from-vision-to-action
#16
REVIEW
Xuedong Zhou, Xin Xu, Jiyao Li, Deyu Hu, Tao Hu, Wei Yin, Yujiang Fan, Xingdong Zhang
Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China...
January 17, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#17
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29342955/pharmacokinetics-of-schizandrin-and-its-pharmaceutical-products-assessed-using-a-validated-lc-ms-ms-method
#18
Chi-Lin Li, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
Schisandra chinensis has been used as an important component in various prescriptions in traditional Chinese medicine and, more recently, in Western-based medicine for its anti-hepatotoxic effect. The aim of this study was to develop a selective, rapid, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method for pharmacokinetic studies of schizandrin in rats. Liquid-liquid extraction was used for plasma sample preparation. A UHPLC reverse-phase C18e column (100 mm × 2.1 mm, 2 μm) coupled with a mobile phase of methanol-0...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342936/structure-characterization-of-honey-processed-astragalus-polysaccharides-and-its-anti-inflammatory-activity-in-vitro
#19
Jingzhu Liao, Chanyi Li, Jing Huang, Wuping Liu, Hongce Chen, Shuangye Liao, Hongyuan Chen, Wen Rui
Honey-processed Astragalus is a dosage form of Radix Astragalus mixed with honey by a traditional Chinese medicine processing method which strengthens the tonic effect. Astragalus polysaccharide (APS), perform its immunomodulatory effects by relying on the tonic effect of Radix Astragalus, therefore, the improved pharmacological activity of honey-processed Astragalus polysaccharide (HAPS) might be due to structural changes during processing. The molecular weights of HAPS and APS were 1,695,788 Da, 2,047,756 Da, respectively, as determined by high performance gel filtration chromatography combined with evaporative light scattering detection (HPGFC-ELSD)...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342933/in-vitro-anticoagulant-activity-and-active-components-of-safflower-injection
#20
Kai-Hong Wang, Shi-Fei Li, Yi Zhao, Hong-Xia Li, Li-Wei Zhang
Safflower injection is well-known as a traditional Chinese medicine used to improve the blood circulation. In this study, seven safflower injection samples from different companies were evaluated for their in vitro anticoagulant activity by measuring their activated partial thromboplastin time (APTT) and prothrombin time (PT) against human plasma. The screening results suggested that the safflower injections exhibited a significant prolonging influence on APTT (p < 0.05 vs. the control group), but not on prolonging PT (p > 0...
January 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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