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https://www.readbyqxmd.com/read/28917142/reactions-of-tobacco-genotypes-with-different-antioxidant-capacities-to-powdery-mildew-and-tobacco-mosaic-virus-infections
#1
Gábor Gullner, Csilla Juhász, Adél Németh, Balázs Barna
The interactions of powdery mildew (Golovinomyces orontii) and Tobacco mosaic virus (TMV) with tobacco lines having down or upregulated antioxidants were investigated. Xanthi-nc, its salicylic acid-deficient NahG mutant, a paraquat-sensitive Samsun (PS) and its paraquat tolerant (PT) mutant were used. Cell membrane damage caused by H2O2 was significantly higher in NahG than Xanthi, whereas it was lower in PT than in PS. Leakage of ions from PT was reduced by the powdery mildew infection. On the other hand TMV inoculation led to a 6-fold and 2-fold elevation of ion leakage from hypersensitive resistant NahG and Xanthi leaves, respectively, whereas ion leakage increased slightly from susceptible PS leaves...
September 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28912408/-results-of-a-drug-use-survey-of-filgrastim-biosimilar-1-filgrastim-bs-syringe-for-inj-mochida-and-f
#2
Tsukasa Teshima, Nao Takigawa, Yuki Makita, Chinatsu Kushiya
With the aim of evaluating the safety and efficacy of filgrastim biosimilar 1(Filgrastim BS syringe for Inj. "MOCHIDA"and "F"), we conducted a drug use results survey of this product for its indications, including mobilization of hematopoietic stem cells into peripheral blood and chemotherapy-induced neutropenia. Of the 518 cases enrolled between August 2013 and July 2015, 495 were selected to be subjects of our safety and efficacy evaluations. 37 cases (7.47%)experienced side effects, which were mainly lower back pain(19, 3...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28911062/tpf-plus-cetuximab-induction-chemotherapy-followed-by-biochemoradiation-with-weekly-cetuximab-plus-weekly-cisplatin-or-carboplatin-a-randomized-phase-ii-eortc-trial
#3
P M Specenier, E Remenar, J Buter, D L Schrijvers, C Bergamini, L F Licitra, A Awada, P M Clement, C Fortpied, J Menis, J B Vermorken
Background: Our aim was to test the safety of cetuximab added to chemoradiation with either cisplatin or carboplatin after prior induction chemotherapy. Methods: Patients with stage III/IV unresectable, squamous cell carcinoma of the head and neck received up to four cycles of TPF-E (cisplatin and docetaxel 75 mg/m2 on day 1 followed by 5-FU 750 mg/m2/day as a continuous infusion on days 1-5 plus cetuximab at a loading dose of 400 mg/m2 followed by a weekly dose of 250 mg/m2), with prophylactic antibiotics but no growth factors...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28906088/bullous-cutaneous-larva-migrans-case-series-and-review-of-atypical-clinical-presentations
#4
Stefano Veraldi, Ermira Çuka, Paolo Pontini, Fabrizio Vaira
Hookworm-related cutaneous larva migrans (HRCLM) is caused by the penetration and migration in the epidermis of larvae of Ancylostoma braziliense and Ancylostoma caninum. It is characterized by slightly raised and erythematous tracks, located especially on the feet. These tracks may be single or multiple, serpiginous or linear, ramified and intertwined, accompanied by pruritus. Atypical clinical presentations of HRCLM are currently more frequent than in the past. We present six patients with bullous HRCLM and discuss the possible pathogenetic factors...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28904717/aseptic-meningitis-following-a-bupivacaine-spinal-anesthesia
#5
Nawfal Doghmi, Amine Meskine, Aziz Benakroute, Mustapha Bensghir, Abdelouahed Baite, Charki Haimeur
Spinal anesthesia complicated by meningitis is rare. The diagnosis is difficult and the clinical signs are unspecific. There is a subgroup called aseptic meningitis of a different mechanism (hypersensitive reaction and irritation of the meninges), which must be identified for appropriate care. We report the case of aseptic meningitis resulting from bupivacaine use complicating spinal anesthesia. She is 31 years old and was admitted to the intensive care unit for meningitis following a Caesarean delivery. 10 hours after the procedure, she was found to have severe headache, neck stiffness and was found restless...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28902736/incidental-131i-activity-in-the-deltoid-region-on-posttherapy-radioiodine-scan
#6
Mark D Strober, Brandon R Callahan
A 71-year-old woman underwent a posttherapy radioiodine scan after I administration for papillary thyroid carcinoma. On day 1 of the posttreatment hospital isolation, the patient received a Pneumovax injection in the left deltoid muscle. A localized hypersensitivity reaction ensued with development of soft tissue edema and erythema at the Pneumovax injection site. This localized reaction persisted up to the subsequent posttherapy radioiodine scan 5 days after injection. Increased activity at the left deltoid region suggests a false-positive finding related to radiotracer sequestration due to inflammation from a localized postvaccination hypersensitivity reaction...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28901381/anti%C3%A2-allergic-action-of-bacillus-calmette%C3%A2-guerin-extract-in-experimental-mast-cell%C3%A2-mediated-anaphylactic-models
#7
Mingli Sun, Yong Wang, Haishan Zhao, Weifan Yao, Xiaosong Yu
Allergy is an acquired hypersensitivity reaction of the immune system mediated by IgE‑induced mast cell degranulation. In China, bacillus Calmette‑Guerin extract (BCGE) has been shown to be clinically effective for regulating immunity, which enhances the resistance of the body to anaphylactic disease, infectious diseases and cancer. However, the mechanisms remain to be fully elucidated. The present study investigated the potential anti‑allergic effects of BCGE in animal models of mast cell‑dependent anaphylaxis and mechanisms of BCGE in mast cells...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901214/total-dose-iron-dextran-infusion-versus-oral-iron-for-treating-iron-deficiency-anemia-in-pregnant-women-a-randomized-controlled-trial
#8
A M Darwish, E E Khalifa, E Rashad, E Farghally
STUDY OBJECTIVE: To test safety, efficacy and cost-effectiveness of total dose infusion (TDI) of low molecular weight (LMW) iron dextran for treatment of iron deficiency anemia (IDA) during pregnancy in comparison to oral ferrous fumarate. DESIGN: Prospective interventional randomized controlled trial (RCT). Design classification. Canadian Task Force II3. SETTING: Antenatal clinic and causality unit of a tertiary care referral facility and University Hospital...
September 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28898962/occupational-rhinoconjunctivitis-caused-by-the-common-indoor-plant-hoya-compacta
#9
D Sherson, A D Nielsen, C G Mortz, L Vestergaard, L P A Brandt, E Jørs, J Bælum
Background: Allergic reactions to the common house plant Hoya compacta (HC) have not previously been described. Aims: To confirm HC as the cause of rhinoconjunctivitis in three horticultural workers. Methods: Greenhouse working conditions were reproduced in our challenge chamber. Results: All three cases developed rhinoconjunctivitis when working with HC plants. A control challenge was performed in two cases with iceberg lettuce causing no symptoms...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28895363/-characterization-of-n-glycosylation-in-an-anti-egfr-monoclonal-antibody-produced-by-different-expression-systems
#10
Chong Wang, Huaizu Guo
The use of mammalian expression systems results in a remarkable heterogeneity of mAb products, generally due to post-translational modifications, and glycosylation is a critical post-translation modification because it has a profound impact on the safety and efficacy of mAbs. The present study was designed to explore the impact of a different expression system on mAb N-glycosylation. The detailed structures of individual glycans between anti-EGFR monoclonal antibodies produced by different expression systems were successfully characterized at the level of free oligosaccharides using liquid chromatography electrospray ionization quadrupole time-of-fight mass spectrometry (LC-ESI-QTof MS)...
June 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28894468/a-case-of-immediate-hypersensitivity-reaction-to-maltitol
#11
Ana Rodríguez Trabado, Carmen Cámara Hijón, José Antonio García-Trujillo, Irene Magriz Trascón, Luis Miguel Fernández Pereira
BACKGROUND: Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient. It has not been previously described as an agent involved in immediate hypersensitivity reactions. METHODS: We report on an anaphylactoid reaction with pharyngeal occlusion suffered by a 60-year-old man after ingestion of a candy containing maltitol syrup. A prick-to-prick test was performed with the candy and maltitol powder...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28893128/urticarial-reaction-following-endovascular-embolization-of-an-orbital-arteriovenous-malformation-avm-with-n-butyl-cyanoacrylate-nbca-glue
#12
Kunal R Sinha, Gary Duckwiler, Daniel B Rootman
Orbital arteriovenous malformations (AVMs) are rare vascular lesions that may be managed with endovascular embolization followed by surgical resection. Embolization is often accomplished with n-butyl-2-cyanoacrylate (nBCA), which is considered to be a safe and effective liquid occlusive agent. Localized vascular inflammation has been associated with endovascular nBCA use in histopathologic studies, but reports of systemic hypersensitivity reactions following endovascular embolization with nBCA are rare. We present a case of a 26-year-old male who developed an intermittent systemic urticarial reaction without cardiopulmonary compromise beginning four weeks after nBCA embolization of an orbital AVM...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28893093/practical-approach-to-the-treatment-of-nsaid-hypersensitivity
#13
Natalia Blanca-Lopez, Diana Perez-Alzate, Gabriela Canto, Miguel Blanca
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently involved in drug hypersensitivity reactions (DHR). NSAIDs are prescribed for different processes and some NSAIDs can be obtained over the counter. Areas covered: We analyse the practical approaches for managing and treating NSAID-DHR considering the five major groups of entities recognised, divided into two categories: those responding to strong COX-1 inhibitors and possibly weak COX-1 or selective COX-2 inhibitors named cross-intolerant (CI), and those induced by a single drug or drug group with good tolerance to strong COX-1 inhibitors, known as allergic reactions (SR)...
September 12, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28892222/oral-challenge-without-skin-tests-in-children-with-non-severe-betalactam-hypersensitivity-time-to-change-the-paradigm
#14
Luis Moral, Jean-Cristoph Caubet
Suspected allergy to penicillins and cephalosporins is very common in childhood. After a proper evaluation, allergy will be confirmed only in a small portion of them. Intradermal tests are usually part of the allergy workup, but they are painful for children and time-consuming, and their role has been debated. A systematic review found only two studies reporting a positive predictive value of skin tests in children of 36% and 33%, respectively, leading to a high rate of inaccurate diagnosis. Moreover, considering that skin tests are negative in more than 90-95% of cases, an oral provocation test (OPT) is finally needed to confirm tolerance in most of these children...
September 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28891542/drug-induced-stevens-johnson-syndrome-in-indian-population-a-multicentric-retrospective-analysis
#15
H N Hirapara, T K Patel, M J Barvaliya, C Tripathi
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening hypersensitivity reactions mainly caused by drugs. Data on incubation period, hospital stay, and outcome for HIV-positive patients are sparse. Role of corticosteroids in their management is still controversial. METHODS: Indoor cases of SJS, SJS-TEN overlap, and TEN were analyzed for causative drugs, incubation period, a severity-of-illness score for toxic epidermal necrolysis (SCORTEN) score, HIV status, treatment, and outcome...
August 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28891449/role-of-pharmacogenomics-in-antiepileptic-drug-therapy-current-status-and-future-perspectives
#16
Antonio Gambardella, Angelo Labate, Laura Mumoli, Iscia Lopes-Cendes, Fernando Cendes
BACKGROUND: Growing evidence indicates that pharmacogenomics will positively impact treatment for patients with epilepsy in the near future, leading to the implementation of a precision-based use of antiepileptic drug (AED) therapy, thereby providing a cornerstone for precision medicine. OBJECTIVE: In this review, we briefly summarize the studies of pharmacogenomics in epilepsy, recent advances, and how it may progress in the future. METHODS: We subdivided the review into two main sections: genetic variants that may modulate response to AEDs through pharmacokinetics or pharmacodynamics mechanisms; and gene variants that may affect tolerability and safety of AEDs...
September 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28890990/child-with-allergies-or-allergic-reactions
#17
REVIEW
Reshma A, Arun K Baranwal
Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hypersensitivity reactions to common environmental and food antigens. Although most of them are self-limiting, they may adversely affect the quality of life and sometimes become life-threatening as well...
September 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28889362/a-novel-aza-mbp-altered-peptide-ligand-for-the-treatment-of-experimental-autoimmune-encephalomyelitis
#18
Nicole N M Trager, Jonathan T Butler, Jennifer Harmon, Joshua Mount, Maria Podbielska, Azizul Haque, Naren L Banik, Craig C Beeson
Myelin basic protein (MBP) is a major target of T cells in lesions of multiple sclerosis (MS) patients and its animal model, experimental autoimmune encephalomyelitis (EAE). Interactions between the major histocompatibility complex II containing antigenic peptides and the T cell receptor activate CD4+ T cells that perpetuate EAE and MS. Previously reported data has shown that treating with an altered peptide ligand (APL) in which the normal antigenic peptide sequence of MBP has been slightly changed at T cell contact positions is helpful in reducing disease in both rodents and humans...
September 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28888249/do-corticosteroids-prevent-biphasic-anaphylaxis
#19
Waleed Alqurashi, Anne K Ellis
Anaphylaxis is a severe hypersensitivity reaction that is rapid in onset and can result in death. The pattern of an anaphylactic reaction can be uniphasic (or monophasic), biphasic (also called delayed or late phase), or refractory in nature. The most widely cited definition of biphasic anaphylaxis is a recurrence of anaphylactic symptoms after initial resolution despite no further exposure to the trigger. Corticosteroids are thought by some to prevent the development of biphasic symptoms and, therefore, commonly used in the emergency treatment of anaphylaxis but this has not been systemtically analyzed...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28886946/postmarketing-safety-surveillance-of-trivalent-recombinant-influenza-vaccine-reports-to-the-vaccine-adverse-event-reporting-system
#20
Emily Jane Woo, Pedro L Moro, Maria Cano, Christopher Jankosky
On January 16, 2013, the Food and Drug Administration approved recombinant hemagglutinin influenza vaccine (RIV3) (Spodoptera frugiperda cell line; Flublok), which is the first completely egg-free flu vaccine licensed in the United States. To improve our understanding of the safety profile of this vaccine, we reviewed and summarized reports to the Vaccine Adverse Event Reporting System (VAERS) following RIV3. Through June 30, 2016, VAERS received 88 reports. Allergic reactions, including anaphylaxis, were the most common type of adverse event...
September 5, 2017: Vaccine
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