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https://www.readbyqxmd.com/read/29241755/autoimmune-skin-diseases-and-the-metabolic-syndrome
#1
Begüm Ünlü, Ümit Türsen
The metabolic syndrome represents an important association of cutaneous maladies with cardiovascular illnesses. Chronic inflammation, shared risk factors (ie, smoking and alcohol consumption), treatment (ie, immunosuppressive agents and drugs that alter the lipid profile), and shared genetic risk loci have been proposed to the cause metabolic syndrome and cardiovascular morbidity of autoimmune diseases. There are many possible inflammatory mediators that are suggested to play a role in insulin resistance pathogenesis, such as tumor necrosis factor-α, interleukin-6, leptin, and adiponectin...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29234717/vulvar-lichen-planus-pemphigoides
#2
J Loyal, S Rashtak
Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. This clinical scenario can be confused with a number of similarly appearing entities such as erosive vulvar lichen planus, mucous membrane pemphigoid, and erosive lichen sclerosus et atrophicus...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29230227/anti-idiotypic-antibodies-against-bp-igg-prevent-type-xvii-collagen-depletion
#3
Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu
Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However, little is known about the precise mechanisms of IVIg in BP. We investigate the cellular effects of IVIg, toward treatments for BP. Keratinocytes were treated with IgG from BP patients (BP-IgG) and with IVIg, and then the COL17 expression was detected by Western blotting...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29228499/high-dose-intravenous-immunoglobulins-for-the-treatment-of-dermatological-autoimmune-diseases
#4
Jochen H O Hoffmann, Alexander H Enk
Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy...
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29227569/new-diagnosis-of-bullous-pemphigoid-after-withdrawal-of-immunosuppressive-therapy-in-a-failed-renal-transplant-recipient-on-hemodialysis
#5
Sohail Abdul Salim, Litty Thomas, Amanda Quorles, Seyed Mehrdad Hamrahian, Tibor Fülöp
The occurrence of the autoimmune blistering disease, bullous pemphigoid (BP), in patients with failed renal allograft is rare and the few reported cases suggest various provocative factors without reaching a consensus. Here we report the case of a patient presenting with bullous lesions soon after the complete discontinuation of immunosuppressant therapy following renal allograft failure. Skin biopsy confirmed the diagnosis of BP. Administration of systemic corticosteroid controlled the occurrence of BP lesions in our patient...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29222810/monocytes-enhance-neutrophil-induced-blister-formation-in-an-ex-vivo-model-of-bullous-pemphigoid
#6
E de Graauw, C Sitaru, M P Horn, L Borradori, S Yousefi, D Simon, H-U Simon
BACKGROUND: Lesions of bullous pemphigoid (BP), an autoimmune subepidermal blistering disease characterized by the presence of tissue-bound and circulating autoantibodies to hemidesmosomal antigens, harbour a mixed inflammatory cellular infiltrate. In various models, neutrophils, eosinophils, mast cells, monocytes as well as B and T cells have been shown to be involved in the pathogenesis of BP. However, their interactions with and effective role in blister formation remains uncertain...
December 8, 2017: Allergy
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#7
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29208790/oral-manifestation-in-patients-diagnosed-with-dermatological-diseases
#8
Sanjay G Thete, Meena Kulkarni, Atul P Nikam, Tejashree Mantri, Dhiraj Umbare, Sushant Satdive, Dinraj Kulkarni
AIM: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India. MATERIALS AND METHODS: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29208261/recurrent-malignancy-associated-atypical-neutrophilic-dermatosis-with-noninfectious-shock
#9
REVIEW
Kathryn Nicole Kinser, Kamaldeep Panach, Arturo Ricardo Dominguez
Sweet syndrome (SS) or acute febrile neutrophilic dermatosis presents with the sudden onset of fever, leukocytosis and tender, erythematous, edematous, well-demarcated papules and plaques that histopathologically demonstrate a dense neutrophilic infiltrate. A total of 20% of patients with SS have malignancy-associated disease that can present with bullous or atypical skin lesions that mimic pyoderma gangrenosum, another neutrophilic dermatosis. Both entities exist on a spectrum, and in the context of underlying malignancy, these neutrophilic diseases become less clinically distinct...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29205468/case-of-epidermolysis-bullosa-acquisita-with-concomitant-anti-laminin-332-antibodies
#10
Emi Nishida, Eiichi Nishio, Hiroko Murashima, Norito Ishii, Takashi Hashimoto, Akimichi Morita
Subepidermal autoimmune blistering disease including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, anti-laminin-γ1 pemphigoid, linear immunoglobulin A bullous disease and epidermolysis bullosa acquisita (EBA), are all characterized by direct immunofluorescence microscopy or immunoglobulin deposition on the basement membrane zone. Among them, EBA is a rare acquired subepidermal autoimmune blistering disease of the skin and mucous membranes reactive with type VII collagen, a major component of the epidermal basement membrane zone...
December 4, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29203970/expression-of-the-jak-stat-signaling-pathway-in-bullous-pemphigoid-and-dermatitis-herpetiformis
#11
K Juczynska, A Wozniacka, E Waszczykowska, M Danilewicz, M Wagrowska-Danilewicz, J Wieczfinska, R Pawliczak, A Zebrowska
A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute to pathogenesis of autoimmune diseases; however, there are no reports concerning autoimmune bullous diseases yet to be published. The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29197074/bullous-pemphigoid-complicated-by-cytomegalovirus-disease-as-a-manifestation-of-immune-reconstitution-inflammatory-syndrome-retrospective-analyses-of-our-institutional-cases-and-literature-review
#12
Yoko M Narita, Chiho Horie, Kazuhisa Hirahara, Yoko Kano, Tetsuo Shiohara, Yoshiko Mizukawa
BACKGROUND: Cytomegalovirus (CMV) disease induced by reactivation of latent CMV is a fatal viral infection that may develop in a setting of therapy with immunosuppressive agents. There is a clear need to clarify any clinical features and markers of CMV disease. OBJECTIVE: We investigated which clinical markers usually available in a clinical setting can predict CMV disease occurring in bullous pemphigoid (BP) patients receiving corticosteroids. METHOD: We described a BP patient with CMV disease complicated by gastrointestinal hemorrhage and liver dysfunction...
December 2, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29191376/clinical-histological-immunological-presentations-and-outcomes-of-bullous-systemic-lupus-erythematosus-10-new-cases-and-a-literature-review-of-118-cases
#13
Tullia de Risi-Pugliese, Fleur Cohen Aubart, Julien Haroche, Philippe Moguelet, Sabine Grootenboer-Mignot, Alexis Mathian, Saskia Ingen-Housz-Oro, Miguel Hie, Noémie Wendremaire, Françoise Aucouturier, François Lepelletier, Makoto Miyara, Brigitte Bader-Meunier, Philippe Rémy, Nicole Fabien, Camille Francès, Stéphane Barete, Zahir Amoura
BACKGROUND: Bullous systemic lupus erythematosus (BSLE) is a rare blistering condition associated with systemic lupus erythematosus (SLE). PATIENTS AND METHODS: We conducted a multi-center retrospective study and literature review in order to describe the clinical, immunological, and histological presentations and outcomes of BSLE. The skin biopsies were centrally reviewed, and sera obtained during a flare of BSLE were analyzed for identification of circulating anti-basement membrane zone antibodies...
November 4, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29178331/response-to-bullous-pemphigoid-inguinalis
#14
Anuradha Bishnoi, Tarun Narang, Sanjeev Handa
We appreciate the constructive comments by author Abdelmaksoud in response to our report of bullous pemphigoid (BP) presenting in association with metastatic penile squamous cell carcinoma (SCC). Though our patient had few blisters on the back, upper limbs and oral cavity, the chief brunt of the disease was on the inguinal area. Cases of localized BP, arising after radiotherapy for breast carcinoma have been reported. Our patient developed BP before receiving radiotherapy. This article is protected by copyright...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29169561/atypical-vesicular-bullous-hand-foot-mouth-disease-in-2-adults
#15
Á Iglesias-Puzas, A Batalla, M Trigo, Á Flórez
No abstract text is available yet for this article.
November 20, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29165802/treatment-of-severe-drug-reactions-by-hemodialysis
#16
Rokea A El-Azhary, Michael Z Wang, Ashley B Wentworth, LaTonya J Hickson
BACKGROUND: Extracorporeal treatments such as hemodialysis and plasma exchange are lifesaving measures in the treatment of drug poisoning. This treatment method generally is not used for severe cutaneous and systemic drug reactions. METHODS: Here, we describe three cases wherein hemodialysis therapy was instrumental in reversing the adverse drug reaction. RESULTS: In the cases of severe cutaneous drug reactions reviewed, patients presented with linear immunoglobulin A bullous dermatosis, acute generalized exanthematous pustulosis, and toxic epidermal necrolysis...
November 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29165796/international-bullous-diseases-group-consensus-on-diagnostic-criteria-for-epidermolysis-bullosa-acquisita
#17
REVIEW
C Prost-Squarcioni, F Caux, E Schmidt, M F Jonkman, S Vassileva, S C Kim, P Iranzo, M Daneshpazhooh, J Terra, J Bauer, J Fairley, R Hall, M Hertl, J S Lehman, B Marinovic, A Patsatsi, D Zillikens, V Werth, D T Woodley, D F Murrell
BACKGROUND: Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease disease with variable clinical presentations and multiple possible diagnostic tests making an international consensus on diagnosis of EBA needed. OBJECTIVES: To obtain an international consensus on the clinical and diagnostic criteria for EBA. METHODS: The international bullous diseases group (IBDG) met three times to discuss the clinical and diagnostic criteria for EBA...
November 22, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29159879/new-insights-into-pemphigoid-diseases
#18
Frank Antonicelli, Ralf J Ludwig
Pemphigus and pemphigoid diseases are organ-specific autoimmune blistering diseases (AIBD), characterized and caused by autoantibodies to structural components of the skin (1). The autoantigens targeted in pemphigus are desmoglein 1 and 3, two proteins of the desmosomal structure, while the autoantigens in pemphigoid diseases (PD) are components of the basal membrane. For example, bullous pemphigoid (BP), the most frequent PD is characterized by autoantibodies against type XVII collagen (COL17, BP180) and BP230, and epidermolysis bullosa acquisita (EBA) is caused by autoantibodies against type VII collagen (COL7)...
November 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29159697/subepidermal-autoimmune-bullous-diseases-overview-epidemiology-and-associations
#19
REVIEW
Khalaf Kridin
Subepidermal autoimmune bullous diseases of the skin and mucosae comprise a large group of chronic diseases, including bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, linear IgA bullous dermatosis, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. These diseases are characterized by an antibody response toward structural components of the basement membrane zone, resulting in subepidermal blistering. The epidemiological features of these diseases vary substantially in different regions of the world...
November 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29140836/pyoderma-gangrenosum-a-critical-appraisal
#20
Eran Shavit, Afsaneh Alavi, R Gary Sibbald
GENERAL PURPOSE: To provide information about pyoderma gangrenosum (PG), including pathophysiology, diagnostic criteria, and treatment. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Pyoderma gangrenosum (PG) is an uncommon cutaneous disease, presenting with recurrent painful ulcerations most commonly on the lower extremities...
December 2017: Advances in Skin & Wound Care
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