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https://www.readbyqxmd.com/read/28416823/-identification-of-a-new-pro-invasion-factor-in-tumor-microenvironment-progress-in-function-and-mechanism-of-extracellular-atp
#1
W G Fang, X X Tian
Up to 90% of all cancer related morbidity and mortality can be attributed to metastasis. In recent years the study of tumor microenvironment, its cellular and molecular components, and how they can affect neoplastic progression toward metastasis, has become a hot focus in cancer research. Accumulated evidence shows that the formation of metastasis is a multi-step sequential process, in which, the tumor cells continuously interact with the host microenvironment. Host derived factors, i.e. growth factors/inhibitors, angiogenic factors, chemokines, etc...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28415138/the-roles-of-valuation-and-reward-processing-in-cognitive-function-and-psychiatric-disorders
#2
REVIEW
Sébastien Hélie, Farzin Shamloo, Keisha Novak, Dan Foti
In neuroeconomics, valuation refers to the process of assigning values to states and actions on the basis of the animal's current representation of the environment, while reward processing corresponds to processing the feedback received from the environment to update the values of states and actions. In this article, we review the brain circuits associated with valuation and reward processing and argue that these are fundamental processes critical to many cognitive functions. Specifically, we focus on the role of valuation and reward processing in attention, memory, decision making, and learning...
April 17, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28384336/filthy-lucre-a-metagenomic-pilot-study-of-microbes-found-on-circulating-currency-in-new-york-city
#3
Julia M Maritz, Steven A Sullivan, Robert J Prill, Emre Aksoy, Paul Scheid, Jane M Carlton
BACKGROUND: Paper currency by its very nature is frequently transferred from one person to another and represents an important medium for human contact with-and potential exchange of-microbes. In this pilot study, we swabbed circulating $1 bills obtained from a New York City bank in February (Winter) and June (Summer) 2013 and used shotgun metagenomic sequencing to profile the communities found on their surface. Using basic culture conditions, we also tested whether viable microbes could be recovered from bills...
2017: PloS One
https://www.readbyqxmd.com/read/28375645/the-fit-game-iii-reducing-the-operating-expenses-of-a-game-based-approach-to-increasing-healthy-eating-in-elementary-schools
#4
Damon Joyner, Heidi J Wengreen, Sheryl S Aguilar, Lori Andersen Spruance, Brooke A Morrill, Gregory J Madden
OBJECTIVE: Previously published versions of the healthy eating "FIT Game" were administered by teachers in all grades at elementary schools. The present study evaluated whether the game would retain its efficacy if teachers were relieved of this task; presenting instead all game materials on visual displays in the school cafeteria. MATERIALS AND METHODS: Participants were 572 children attending two Title 1 elementary schools (grades K-5). Following a no-intervention baseline period in which fruit and vegetable consumption were measured from food waste, the schools played the FIT Game...
April 2017: Games for Health
https://www.readbyqxmd.com/read/28370293/a-framework-for-predicting-impacts-on-ecosystem-services-from-sub-organismal-responses-to-chemicals
#5
REVIEW
Valery E Forbes, Chris J Salice, Bjorn Birnir, Randy J F Bruins, Peter Calow, Virginie Ducrot, Nika Galic, Kristina Garber, Bret C Harvey, Henriette Jager, Andrew Kanarek, Robert Pastorok, Steve F Railsback, Richard Rebarber, Pernille Thorbek
Protection of ecosystem services is increasingly emphasized as a risk-assessment goal, but there are wide gaps between current ecological risk-assessment endpoints and potential effects on services provided by ecosystems. The authors present a framework that links common ecotoxicological endpoints to chemical impacts on populations and communities and the ecosystem services that they provide. This framework builds on considerable advances in mechanistic effects models designed to span multiple levels of biological organization and account for various types of biological interactions and feedbacks...
April 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28368709/using-the-pictorial-representation-of-illness-and-self-measure-prism-to-quantify-and-compare-suffering-from-trauma-and-addiction
#6
Tim Kok, Hein A De Haan, Tom Sensky, Margreet van der Meer, Cor A J De Jong
OBJECTIVE: In a sample of people with substance use disorder who had experienced psychological trauma, this study aimed to quantify differences in perceived suffering due to addiction-related problems and to trauma-related problems. METHODS: The sample comprised 146 inpatients with substance use disorder: 25% had posttraumatic stress disorder (PTSD), 21% had subthreshold PTSD; and the remainder constituted the trauma-only group. PTSD, substance use disorder, and suffering were assessed using validated instruments...
February 22, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28359273/a-comparison-of-generic-drug-prices-in-seven-european-countries-a-methodological-analysis
#7
Olivier J Wouters, Panos G Kanavos
BACKGROUND: Policymakers and researchers frequently compare the prices of medicines between countries. Such comparisons often serve as barometers of how pricing and reimbursement policies are performing. The aim of this study was to examine methodological challenges to comparing generic drug prices. METHODS: We calculated all commonly used price indices based on 2013 IMS Health data on sales of 3156 generic drugs in seven European countries. RESULTS: There were large differences in generic drug prices between countries...
March 31, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28357171/value-based-care-in-the-worldwide-battle-against-cancer
#8
REVIEW
Niloufer J Johansen, Christobel M Saunders
Globally, an increasing and aging population is contributing to the prevalence of cancer. To be effective, cancer care needs to involve the coordination of multidisciplinary specialties, and also needs to be affordable, accessible, and capable of producing optimal patient outcomes. Porter and Teisberg (2006) have postulated that shifting current healthcare strategies from volume-based to patient-centric care redirects economic competition to providing treatments which promote the best patient outcomes while driving down costs...
February 17, 2017: Curēus
https://www.readbyqxmd.com/read/28344971/how-to-train-a-cell-cutting-edge-molecular-tools
#9
REVIEW
Jakub Czapiński, Michał Kiełbus, Joanna Kałafut, Michał Kos, Andrzej Stepulak, Adolfo Rivero-Müller
In biological systems, the formation of molecular complexes is the currency for all cellular processes. Traditionally, functional experimentation was targeted to single molecular players in order to understand its effects in a cell or animal phenotype. In the last few years, we have been experiencing rapid progress in the development of ground-breaking molecular biology tools that affect the metabolic, structural, morphological, and (epi)genetic instructions of cells by chemical, optical (optogenetic) and mechanical inputs...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28336748/the-sweet-side-of-ampk-signaling-regulation-of-gfat1
#10
John W Scott, Jonathan S Oakhill
Maintaining a steady balance between nutrient supply and energy demand is essential for all living organisms and is achieved through the dynamic control of metabolic processes that produce and consume adenosine-5'-triphosphate (ATP), the universal currency of energy in all cells. A key sensor of cellular energy is the adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. AMPK is activated by metabolic stresses that decrease cellular ATP, and functions to restore energy balance by orchestrating a switch in metabolism away from anabolic pathways toward energy-generating catabolic processes...
March 23, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28329023/hydro-wind-and-solar-power-as-a-base-for-a-100-renewable-energy-supply-for-south-and-central-america
#11
Larissa de Souza Noel Simas Barbosa, Dmitrii Bogdanov, Pasi Vainikka, Christian Breyer
Power systems for South and Central America based on 100% renewable energy (RE) in the year 2030 were calculated for the first time using an hourly resolved energy model. The region was subdivided into 15 sub-regions. Four different scenarios were considered: three according to different high voltage direct current (HVDC) transmission grid development levels (region, country, area-wide) and one integrated scenario that considers water desalination and industrial gas demand supplied by synthetic natural gas via power-to-gas (PtG)...
2017: PloS One
https://www.readbyqxmd.com/read/28320621/global-reverse-supply-chain-design-for-solid-waste-recycling-under-uncertainties-and-carbon-emission-constraint
#12
Zhitao Xu, Adel Elomri, Shaligram Pokharel, Qin Zhang, X G Ming, Wenjie Liu
The emergence of concerns over environmental protection, resource conservation as well as the development of logistics operations and manufacturing technology has led several countries to implement formal collection and recycling systems of solid waste. Such recycling system has the benefits of reducing environmental pollution, boosting the economy by creating new jobs, and generating income from trading the recyclable materials. This leads to the formation of a global reverse supply chain (GRSC) of solid waste...
March 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28315810/trappings-of-femininity-a-test-of-the-beauty-as-currency-hypothesis-in-shaping-college-women-s-gender-activism
#13
Rachel M Calogero, Tracy L Tylka, Lois C Donnelly, Amber McGetrick, Andrea Medrano Leger
This study investigated whether believing beauty is a primary currency for women operates as an antecedent force in the relation between self-objectification and gender activism. Ninety-four ethnically diverse women attending a small liberal arts college in the southeastern United States completed the study questionnaires online for course credit. Preliminary results demonstrated beauty as currency belief, self-objectification, and support for the gender status quo were negatively associated with gender activism...
March 17, 2017: Body Image
https://www.readbyqxmd.com/read/28303116/comparative-physiology-of-energy-metabolism-fishing-for-endocrine-signals-in-the-early-vertebrate-pool
#14
REVIEW
Iris van de Pol, Gert Flik, Marnix Gorissen
Energy is the common currency of life. To guarantee a homeostatic supply of energy, multiple neuro-endocrine systems have evolved in vertebrates; systems that regulate food intake, metabolism, and distribution of energy. Even subtle (lasting) dysregulation of the delicate balance of energy intake and expenditure may result in severe pathologies. Feeding-related pathologies have fueled research on mammals, including of course the human species. The mechanisms regulating food intake and body mass are well-characterized in these vertebrates...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28301162/determination-of-cell-doubling-times-from-the-return-on-investment-time-of-photosynthetic-vesicles-based-on-atomic-detail-structural-models
#15
Andrew Hitchcock, C Neil Hunter, Melih Sener
Cell doubling times of the purple bacterium Rhodobacter sphaeroides during photosynthetic growth are determined experimentally and computationally as a function of illumination. For this purpose, energy conversion processes in an intracytoplasmic membrane vesicle, the chromatophore, are described based on an atomic detail structural model. The cell doubling time and its illumination dependence are computed in terms of the return-on-investment (ROI) time of the chromatophore, determined computationally from the ATP production rate, and the mass ratio of chromatophores in the cell, determined experimentally from whole cell absorbance spectra...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28298160/new-perspectives-on-health-professions-students-e-learning-looking-through-the-lens-of-the-visitor-and-resident-model
#16
Maralyn Druce, Stella Howden
BACKGROUND: The growth of e-learning in health professional education reflects expansion of personal use of online resources. Understanding the user perspective in a fast-changing digital world is essential to maintain the currency of our approach. METHODS: Mixed methods were used to investigate a cohort of postgraduate, e-learning healthcare students' perspectives on their use of online resources for personal and/or professional roles, via questionnaire and student-constructed diagrams, capturing use of online resources (underpinned by White's model of "resident" and "visitor" online engagement)...
March 15, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28283488/quality-of-clinical-practice-guidelines-in-delirium-a-systematic-appraisal
#17
Shirley H Bush, Katie L Marchington, Meera Agar, Daniel H J Davis, Lindsey Sikora, Tammy W Y Tsang
OBJECTIVE: To determine the accessibility and currency of delirium guidelines, guideline summary papers and evaluation studies, and critically appraise guideline quality. DESIGN: Systematic literature search for formal guidelines (in English or French) with focus on delirium assessment and/or management in adults (≥18 years), guideline summary papers and evaluation studies.Full appraisal of delirium guidelines published between 2008 and 2013 and obtaining a 'Rigour of Development' domain screening score cut-off of >40% using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28283068/energy-in-ancient-metabolism
#18
William F Martin, Rudolf K Thauer
Modern metabolism would not work without ATP and phosphate, but in primordial biochemical networks, energy currencies might have been simpler. Goldford et al. report a novel systems approach to reconstructing energetics in ancient metabolism, with very interesting results.
March 9, 2017: Cell
https://www.readbyqxmd.com/read/28267595/economic-burden-of-herpes-zoster-culebrilla-in-latin-america
#19
Emmanouil Rampakakis, Clare Pollock, Claudia Vujacich, Joao Toniolo Neto, Alejandro Ortiz Covarrubias, Homero Monsanto, Kelly D Johnson
BACKGROUND: Herpes zoster (HZ) is characterized by debilitating pain and blistering dermatomal rash. The most common complication of HZ is postherpetic neuralgia (PHN), a persistent pain that can substantially affect patients' quality of life. HZ has significant impact on patients' lives with considerable implications for healthcare systems and society. The purpose of this study was to evaluate the healthcare resource utilization (HCRU) and medical costs associated with HZ in Latin America...
March 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28259392/financial-fraud-and-health-the-case-of-spain
#20
Maria Victoria Zunzunegui, Emmanuelle Belanger, Tarik Benmarhnia, Milena Gobbo, Angel Otero, François Béland, Fernando Zunzunegui, Jose Manuel Ribera-Casado
OBJECTIVE: To examine whether financial fraud is associated with poor health sleeping problems and poor quality of life. METHODS: Pilot study (n=188) conducted in 2015-2016 in Madrid and León (Spain) by recruiting subjects affected by two types of fraud (preferred shares and foreign currency mortgages) using venue-based sampling. Information on the monetary value of each case of fraud; the dates when subjects became aware of being swindled, lodged legal claim and received financial compensation were collected...
March 2, 2017: Gaceta Sanitaria
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