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https://www.readbyqxmd.com/read/28643592/the-burden-of-multiple-sclerosis-2015-methods-of-data-collection-assessment-and-analysis-of-costs-quality-of-life-and-symptoms
#1
Gisela Kobelt, Jennifer Eriksson, Glenn Phillips, Jenny Berg
INTRODUCTION: This article describes the methods used to perform this large European-wide burden-of-illness study on multiple sclerosis (MS) using individual patient data. METHODS: The study collected all MS-related resource consumption, workforce participation, prevalent disease symptoms and health-related quality of life (HRQoL). Patients were recruited by national patient associations and, after informed consent, completed a specific questionnaire either on-line or on paper...
August 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28624673/a-geographical-analysis-of-trafficking-on-a-popular-darknet-market
#2
Julian Broséus, Damien Rhumorbarbe, Marie Morelato, Ludovic Staehli, Quentin Rossy
Cryptomarkets are online marketplaces, located on the darknet, that facilitate the trading of a variety of illegal goods, mostly drugs. While the literature essentially focus on drugs, various other goods and products related to financial or identity fraud, firearms, counterfeit goods, as well as doping products are also offered on these marketplaces. Through the analysis of relevant data collected on a popular marketplace in 2014-2015, Evolution, this research provides an analysis of the structure of trafficking (types and proportions of products, number of vendors and shipping countries)...
June 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28612187/enhancement-of-energy-production-of-the-intervertebral-disc-by-the-implantation-of-polyurethane-mass-transfer-devices
#3
Yu-Fu Wang, Howard B Levene, Weiyong Gu, C -Y Charles Huang
Insufficient nutrient supply has been suggested to be one of the etiologies for intervertebral disc (IVD) degeneration. We are investigating nutrient transport into the IVD as a potential treatment strategy for disc degeneration. Most cellular activities in the IVD (e.g., cell proliferation and extracellular matrix production) are mainly driven by adenosine-5'-triphosphate (ATP) which is the main energy currency. The objective of this study was to investigate the effect of increased mass transfer on ATP production in the IVD by the implantation of polyurethane (PU) mass transfer devices...
June 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28605384/analyzing-supercomplexes-of-the-mitochondrial-electron-transport-chain-with-native-electrophoresis-in-gel-assays-and-electroelution
#4
Gisela Beutner, George Arthur Porter
The mitochondrial electron transport chain (ETC) transduces the energy derived from the breakdown of various fuels into the bioenergetic currency of the cell, ATP. The ETC is composed of 5 massive protein complexes, which also assemble into supercomplexes called respirasomes (C-I, C-III, and C-IV) and synthasomes (C-V) that increase the efficiency of electron transport and ATP production. Various methods have been used for over 50 years to measure ETC function, but these protocols do not provide information on the assembly of individual complexes and supercomplexes...
June 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28592621/bevacizumab-for-metastatic-colorectal-cancer-a-global-cost-effectiveness-analysis
#5
Daniel A Goldstein, Qiushi Chen, Turgay Ayer, Kelvin K W Chan, Kiran Virik, Ariel Hammerman, Baruch Brenner, Christopher R Flowers, Peter S Hall
BACKGROUND: In the U.S., the addition of bevacizumab to first-line chemotherapy in metastatic colorectal cancer (mCRC) has been demonstrated to provide 0.10 quality-adjusted life years (QALYs) at an incremental cost-effectiveness ratio (ICER) of $571,000/QALY. Due to variability in pricing, value for money may be different in other countries. Our objective was to establish the cost-effectiveness of bevacizumab in mCRC in the U.S., U.K., Canada, Australia, and Israel. METHODS: We performed the analysis using a previously established Markov model for mCRC...
June 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28578916/telling-different-stories-making-new-realities-the-ontological-politics-of-addiction-biographies
#6
Kiran Pienaar, Ella Dilkes-Frayne
Personal narratives of alcohol and other drug addiction circulate widely in popular culture and they also have currency in professional therapeutic settings. Despite this, relatively little research has explored the conventions operating in these narratives and how they shape people's experiences and identities. While research in this area often proceeds on the premise that addiction biographies are straightforwardly 'true' accounts, in this paper we draw on the insights of critical alcohol and other drug scholarship, and the concept of 'ontological politics' to argue that biographies produce normative ideas about addiction and those said to be experiencing it...
May 31, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28552272/understanding-stakeholders-perspectives-and-experiences-of-general-practice-accreditation
#7
Deborah Debono, David Greenfield, Luke Testa, Virginia Mumford, Anne Hogden, Marjorie Pawsey, Johanna Westbrook, Jeffrey Braithwaite
OBJECTIVE: To examine general practice accreditation stakeholders' perspectives and experiences to identify program strengths and areas for improvements. DESIGN, SETTING AND PARTICIPANTS: Individual (n=2) and group (n=9) interviews were conducted between September 2011-March 2012 with 52 stakeholders involved in accreditation in Australian general practices. Interviews were recorded, transcribed and thematically analysed. Member checking activities in April 2016 assessed the credibility and currency of the findings in light of current reforms...
May 19, 2017: Health Policy
https://www.readbyqxmd.com/read/28541592/cath-lab-costs-in-patients-undergoing-percutaneous-coronary-angioplasty-detailed-analysis-of-consecutive-procedures
#8
Beata Dziki, Izabela Miechowicz, Piotr Iwachów, Michał Kuzemczak, Piotr Kałmucki, Andrzej Szyszka, Artur Baszko, Tomasz Siminiak
BACKGROUND: Costs of percutaneous coronary interventions (PCI) have important impact on health care expenditures. Despite the present stress upon the cost-effectiveness issues in medicine, few comprehensive data exist on costs and resource use in different clinical settings. AIM: To assess catheterization laboratory costs related to use of drugs and single-use devices in patients undergoing PCI due to coronary artery disease. METHODS: Retrospective analysis of 1500 consecutive PCIs (radial approach, n=1103; femoral approach, n=397) performed due to myocardial infarction type STEMI (n=345) and NSTEMI (n=426) as well as unstable (UA; n=489) and (SA; n=241) angina was undertaken...
May 25, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28534228/glove-changing-practices-of-mall-food-vendors-in-new-jersey
#9
Corey H Basch, Miryam Z Wahrman, Sarah A MacLean, Alan Quisido, Carlo Ponsica, Nandish Patel
Gloves can serve as barriers to decrease the transfer of microorganisms from hands to food. Glove changing by food vendors is particularly important when handling paper currency, as bills can carry and transmit microbes from person to person. The purpose of this study was two-fold: (1) To ascertain the extent to which gloves are changed after monetary transactions in food vendors at a major mall in New Jersey; and (2) to document the level of bacterial contamination and the presence of coliform bacteria on paper currency handled by these vendors...
May 22, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28521648/an-exploratory-study-of-the-experience-of-fibromyalgia-diagnosis-in-south-africa
#10
Silvie Cooper, Leah Gilbert
Within the conceptual framework of 'medically-ill-defined' conditions, this article focuses on the experiences of 'diagnosis' through a narrative analysis of fibromyalgia (a chronic musculoskeletal pain disorder) in South Africa. In-depth interviews were used to collect narratives from 15 participants. The findings show how the contested and confusing experience of fibromyalgia diagnosis can be understood, by viewing the interactions that patients have with their practitioners, families, peers and colleagues...
May 2017: Health (London)
https://www.readbyqxmd.com/read/28498843/when-bitcoin-encounters-information-in-an-online-forum-using-text-mining-to-analyse-user-opinions-and-predict-value-fluctuation
#11
Young Bin Kim, Jurim Lee, Nuri Park, Jaegul Choo, Jong-Hyun Kim, Chang Hun Kim
Bitcoin is an online currency that is used worldwide to make online payments. It has consequently become an investment vehicle in itself and is traded in a way similar to other open currencies. The ability to predict the price fluctuation of Bitcoin would therefore facilitate future investment and payment decisions. In order to predict the price fluctuation of Bitcoin, we analyse the comments posted in the Bitcoin online forum. Unlike most research on Bitcoin-related online forums, which is limited to simple sentiment analysis and does not pay sufficient attention to note-worthy user comments, our approach involved extracting keywords from Bitcoin-related user comments posted on the online forum with the aim of analytically predicting the price and extent of transaction fluctuation of the currency...
2017: PloS One
https://www.readbyqxmd.com/read/28491867/metabolic-reprogramming-in-glioma
#12
REVIEW
Marie Strickland, Elizabeth A Stoll
Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic currency to accomplish cellular tasks. The contribution of these substrates is increasingly appreciated in the context of glioma, the most common form of malignant brain tumor...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28479996/activity-specific-metabolic-rates-for-diving-transiting-and-resting-at-sea-can-be-estimated-from-time-activity-budgets-in-free-ranging-marine-mammals
#13
Tiphaine Jeanniard-du-Dot, Andrew W Trites, John P Y Arnould, John R Speakman, Christophe Guinet
Time and energy are the two most important currencies in animal bioenergetics. How much time animals spend engaged in different activities with specific energetic costs ultimately defines their likelihood of surviving and successfully reproducing. However, it is extremely difficult to determine the energetic costs of independent activities for free-ranging animals. In this study, we developed a new method to calculate activity-specific metabolic rates, and applied it to female fur seals. We attached biologgers (that recorded GPS locations, depth profiles, and triaxial acceleration) to 12 northern (Callorhinus ursinus) and 13 Antarctic fur seals (Arctocephalus gazella), and used a hierarchical decision tree algorithm to determine time allocation between diving, transiting, resting, and performing slow movements at the surface (grooming, etc...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28460925/willingness-to-pay-more-for-value-added-pomegranate-juice-punica-granatum-l-an-open-ended-contingent-valuation
#14
Karen Rodrigues Romano, Fernanda Dias Bartolomeu Abadio Finco, Amauri Rosenthal, Marcus Vinicius Alves Finco, Rosires Deliza
This study aimed at estimating the consumer's willingness to pay (WTP) more for value-added pomegranate juice using the contingent valuation method (CVM). The WTP was estimated applying the open-ended elicitation technique with 454 consumers in two supermarkets located in Rio de Janeiro, Brazil. The average consumer's WTP more for pomegranate juice was estimated in R$2.04 (Brazilian currency) and the income elasticity coefficient at the midpoint was 0.19, i.e., a 10% increase in consumer income will increase, on average, 1...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28452739/-experimental-model-and-currency-of-experiment-of-distant-results-of-lead-exposition
#15
G Pataraia, T Bagashvili, G Andronikashvili, T Gurashvili, K Gogeshvili, M Avalishvili
In order to explore the distant results of exposition of little doses of lead, for the objective of the experiment model we have selected 32 mongral rats, of different age, but aged of both sex. Experimental animals were divided in two groups. During first two month from the beginning of the experiment, together with permissible food, animals were given the water, in which was open Pb(NO3)2 - to first group 1.5 mg on kg/weight and to II group 15 mg on kg/weight during the day and night. Before the beginning of the experiment, in the time of process and after it, observation was conducted, description and collection of photo-video materials about the behavior of animals, physiological parameters, possible change of weight, clear-sighted changes in appearance...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28450856/toward-a-metagenomic-understanding-on-the-bacterial-composition-and-resistome-in-hong-kong-banknotes
#16
Yoshitaro Heshiki, Thrimendra Dissanayake, Tingting Zheng, Kang Kang, Ni Yueqiong, Zeling Xu, Chinmoy Sarkar, Patrick C Y Woo, Billy K C Chow, David Baker, Aixin Yan, Christopher J Webster, Gianni Panagiotou, Jun Li
Currency is possibly one of the main media transmitting pathogens and drug resistance due to its wide circulation in daily life. In this study, we made a comprehensive characterization of the bacterial community present on banknotes collected from different geographical regions of Hong Kong (HK) by performing in vitro characterization of the bacterial presence and resistome profile, as well as metagenomic analysis including microbial diversity, the prevalence of potential pathogens, the dissemination potential of antibiotic-resistance genes (ARGs), among others...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28435303/economic-benefit-of-back-titration-in-the-treatment-of-hypertension-in-jos-nigeria
#17
Basil N Okeahialam, Michael A Adeniyi
PURPOSE: Treatment of hypertension is expensive and cost is one of the reasons for inadequate blood pressure control. Where there are no social cost cushions, the burden is borne by patients. With pervasive poverty and inadequate control, complications are unchecked. Back titration in appropriate circumstances should, therefore, translate to economic benefit. This is an attempt to compute, in economic terms, the benefit of back titration. PATIENTS AND METHODS: Thirty-nine patients who entered an antihypertensive back titration program for 12 months and who had been earlier reported on, form the subject of this study...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28433256/evolution-and-patterns-of-global-health-financing-1995-2014-development-assistance-for-health-and-government-prepaid-private-and-out-of-pocket-health-spending-in-184-countries
#18
(no author information available yet)
BACKGROUND: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development...
May 20, 2017: Lancet
https://www.readbyqxmd.com/read/28416823/-identification-of-a-new-pro-invasion-factor-in-tumor-microenvironment-progress-in-function-and-mechanism-of-extracellular-atp
#19
W G Fang, X X Tian
Up to 90% of all cancer related morbidity and mortality can be attributed to metastasis. In recent years the study of tumor microenvironment, its cellular and molecular components, and how they can affect neoplastic progression toward metastasis, has become a hot focus in cancer research. Accumulated evidence shows that the formation of metastasis is a multi-step sequential process, in which, the tumor cells continuously interact with the host microenvironment. Host derived factors, i.e. growth factors/inhibitors, angiogenic factors, chemokines, etc...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28415138/the-roles-of-valuation-and-reward-processing-in-cognitive-function-and-psychiatric-disorders
#20
REVIEW
Sébastien Hélie, Farzin Shamloo, Keisha Novak, Dan Foti
In neuroeconomics, valuation refers to the process of assigning values to states and actions on the basis of the animal's current representation of the environment, while reward processing corresponds to processing the feedback received from the environment to update the values of states and actions. In this article, we review the brain circuits associated with valuation and reward processing and argue that these are fundamental processes critical to many cognitive functions. Specifically, we focus on the role of valuation and reward processing in attention, memory, decision making, and learning...
May 2017: Annals of the New York Academy of Sciences
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