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https://www.readbyqxmd.com/read/26303633/intraperitoneal-administration-of-autologous-tolerogenic-dendritic-cells-for-refractory-crohn-s-disease-a-phase-i-study
#1
Aranzazu Jauregui-Amezaga, Raquel Cabezón, Anna Ramírez-Morros, Carolina España, Jordi Rimola, Concepció Bru, Susana Pinó-Donnay, Marta Gallego, Maria Carme Masamunt, Ingrid Ordás, Miguel Lozano, Joan Cid, Julian Panés, Daniel Benítez-Ribas, Elena Ricart
BACKGROUND AND AIMS: Ex vivo-generated autologous tolerogenic dendritic cells [tolDCs] can restore immune tolerance in experimental colitis. The aim of this study was to determine the safety and tolerability of administration of autologous tolDCs in refractory Crohn's disease [CD] patients. METHODS: A phase-I, single-centre, sequential-cohorts, dose-range study was designed. Stable tolDCs were generated ex vivo from monocytes following a previously developed protocol, and administered by sonography-guided intraperitoneal injection...
December 2015: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/26287674/evaluation-of-aminoglycoside-and-non-aminoglycoside-compounds-for-stop-codon-readthrough-therapy-in-four-lysosomal-storage-diseases
#2
Marta Gómez-Grau, Elena Garrido, Mónica Cozar, Víctor Rodriguez-Sureda, Carmen Domínguez, Concepción Arenas, Richard A Gatti, Bru Cormand, Daniel Grinberg, Lluïsa Vilageliu
Nonsense mutations are quite prevalent in inherited diseases. Readthrough drugs could provide a therapeutic option for any disease caused by this type of mutation. Geneticin (G418) and gentamicin were among the first to be described. Novel compounds have been generated, but only a few have shown improved results. PTC124 is the only compound to have reached clinical trials. Here we first investigated the readthrough effects of gentamicin on fibroblasts from one patient with Sanfilippo B, one with Sanfilippo C, and one with Maroteaux-Lamy...
2015: PloS One
https://www.readbyqxmd.com/read/26239287/-extensive-swelling-reaction-after-a-pentavalent-vaccination
#3
M Gébus, C Barbier, C Bost-Bru, A P Michard-Lenoir, D Plantaz
Injection site reactions (ISRs) are quite common side effects defined by a local adverse drug reaction directly caused by a vaccine. Twenty-four hours after an intramuscular injection (in the deltoid muscle) of the diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, Haemophilus influenza type b (DTPCa-Hib) combined vaccine, a 3-year-old boy developed fever. A few hours later, local redness and swelling appeared at the injection site, with rapid extension to the entire limb, it was pain-free, and no other clinical anomalies were present...
September 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26174813/new-suggestive-genetic-loci-and-biological-pathways-for-attention-function-in-adult-attention-deficit-hyperactivity-disorder
#4
Silvia Alemany, Marta Ribasés, Natàlia Vilor-Tejedor, Mariona Bustamante, Cristina Sánchez-Mora, Rosa Bosch, Vanesa Richarte, Bru Cormand, Miguel Casas, Josep A Ramos-Quiroga, Jordi Sunyer Sunyer
Attention deficit is one of the core symptoms of the attention-deficit/hyperactivity disorder (ADHD). However, the specific genetic variants that may be associated with attention function in adult ADHD remain largely unknown. The present study aimed to identifying SNPs associated with attention function in adult ADHD and tested whether these associations were enriched for specific biological pathways. Commissions, hit-reaction time (HRT), the standard error of HRT (HRTSE), and intraindividual coefficient variability (ICV) of the Conners Continuous Performance Test (CPT-II) were assessed in 479 unmedicated adult ADHD individuals...
July 14, 2015: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26141109/-pylephlebitis-a-rare-but-possible-complication-of-intra-abdominal-infections
#5
Susana Pérez-Bru, Carmen Nofuentes-Riera, Andrés García-Marín, Paloma Luri-Prieto, Miguel Morales-Calderón, Salvador García-García
BACKGROUND: Pylephlebitis or septic thrombophlebitis of the portal venous system is a rare but serious complication of intra-abdominal infections which drain into the portal venous system. Its diagnosis is based on clinical suspicion and imaging tests, mainly a computed tomography scan, given the lack of specificity of the signs and symptoms. Spread of septic emboli is the major cause of morbidity and mortality. The aim of the study was to analyse patients diagnosed in our hospital. MATERIAL AND METHODS: Retrospective descriptive study of patients diagnosed with pylephlebitis in our hospital...
November 2015: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/26115328/scoring-system-for-mortality-in-patients-diagnosed-with-and-treated-surgically-for-differentiated-thyroid-carcinoma-with-a-20-year-follow-up
#6
David López-Bru, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Vicente Francisco Gil-Guillén
BACKGROUND: Differentiated thyroid carcinoma (DTC) is associated with an increased mortality. Few studies have constructed predictive models of all-cause mortality with a high discriminating power for patients with this disease that would enable us to determine which patients are more likely to die. OBJECTIVE: To construct a predictive model of all-cause mortality at 5, 10, 15 and 20 years for patients diagnosed with and treated surgically for DTC for use as a mobile application...
2015: PloS One
https://www.readbyqxmd.com/read/26010057/adolescents-sedentary-behaviors-in-two-european-cities
#7
Alberto Aibar Solana, Julien E Bois, Javier Zaragoza, Noëlle Bru, Thierry Paillard, Eduardo Generelo
PURPOSE: The aim of this study was to determine and compare the correlates of objective sedentary behavior (SB) and nonschool self-reported SB in adolescents from 2 midsized cities, 1 in France (Tarbes) and 1 in Spain (Huesca). Stability of objective SB and nonschool self-reported SB were also assessed at different time points during 1 academic year. METHOD: Starting with a total of 829 participants and after applying inclusion criteria, objective SB was assessed for 646 adolescents (Mage = 14...
2015: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/25992570/prognostic-value-of-obesity-on-both-overall-mortality-and-cardiovascular-disease-in-the-general-population
#8
Isabel Ponce-Garcia, Marta Simarro-Rueda, Julio Antonio Carbayo-Herencia, Juan Antonio Divisón-Garrote, Luis Miguel Artigao-Ródenas, Francisco Botella-Romero, Antonio Palazón-Bru, Damian Robert James Martínez-St John, Vicente Francisco Gil-Guillén
BACKGROUND: Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain. MATERIALS AND METHODS: This prospective cohort study used stratified and randomized two-stage sampling...
2015: PloS One
https://www.readbyqxmd.com/read/25876462/nonadherence-to-guidelines-for-prescribing-antibiotic-therapy-to-patients-with-tonsillitis-or-pharyngotonsillitis-a-cross-sectional-study
#9
Pilar Rico-Ferreira, Antonio Palazón-Bru, Miriam Calvo-Pérez, Vicente Francisco Gil-Guillén
OBJECTIVES: Although previous studies have assessed nonadherence to guidelines for prescribing antibiotic therapy in patients with pharyngotonsillitis (prescription of another antibiotic rather than one of first choice: amoxicillin and/or penicillin V, except in the case of penicillin allergy), none analyzed associated factors. Consequently, we conducted a study to assess the possible factors associated with the problem of nonadherence. METHODS: This cross-sectional study analyzed a sample of 417 patients with tonsillitis or pharyngotonsillitis treated with antibiotics during February 2014 in a Spanish region...
2015: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/25833705/differences-in-the-management-of-hypertension-diabetes-mellitus-and-dyslipidemia-between-obesity-classes
#10
D R J Martínez-St John, A Palazón-Bru, V F Gil-Guillén, A Sepehri, F Navarro-Cremades, D Orozco-Beltrán, C Carratalá-Munuera, E Cortés, M M Rizo-Baeza
We did not find any paper that assessed clinical inertia in obese patients. Therefore, no paper has compared the clinical inertia rates between morbidly and nonmorbidly obese patients. A cross-sectional observational study was carried out. We analysed 8687 obese patients ⩾40 years of age who attended their health-care center for a checkup as part of a preventive program. The outcome was morbid obesity. Secondary variables were as follows: failure in the management of high blood pressure (HBP), high blood cholesterol (HBC) and high fasting blood glucose (HFBG); gender; personal history of hypertension, dyslipidemia, diabetes, smoking and cardiovascular disease; and age (years)...
January 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/25831408/effectiveness-analysis-of-active-stretching-versus-active-stretching-plus-low-frequency-electrical-stimulation-in-children-who-play-soccer-and-who-have-the-short-hamstring-syndrome
#11
Francisco Piqueras-Rodríguez, Antonio Palazón-Bru, Vicente F Gil-Guillén
OBJECTIVE: To determine the effectiveness of active stretching (AS) versus AS plus electrical stimulation (stretching + TENS) in young soccer players with the short hamstring syndrome (SHS). DESIGN: Randomized, controlled, single-blind parallel clinical trial with 3 arms and a 2-month follow-up. The assignment ratio was 1:1:1. SETTING: The study involved young federated soccer players in the town of Jumilla, in the region of Murcia (Spain), who were controlled in a physiotherapy office in 2012...
January 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/25761863/systemic-inflammatory-response-and-serum-lipopolysaccharide-levels-predict-multiple-organ-failure-and-death-in-alcoholic-hepatitis
#12
COMPARATIVE STUDY
Javier Michelena, José Altamirano, Juan G Abraldes, Silvia Affò, Oriol Morales-Ibanez, Pau Sancho-Bru, Marlene Dominguez, Juan Carlos García-Pagán, Javier Fernández, Vicente Arroyo, Pere Ginès, Alexandre Louvet, Philippe Mathurin, Wajahat Z Mehal, Juan Caballería, Ramón Bataller
UNLABELLED: Alcoholic hepatitis (AH) frequently progresses to multiple organ failure (MOF) and death. However, the driving factors are largely unknown. At admission, patients with AH often show criteria of systemic inflammatory response syndrome (SIRS) even in the absence of an infection. We hypothesize that the presence of SIRS may predispose to MOF and death. To test this hypothesis, we studied a cohort including 162 patients with biopsy-proven AH. The presence of SIRS and infections was assessed in all patients, and multivariate analyses identified variables independently associated with MOF and 90-day mortality...
September 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/25536995/melitococcosis-in-the-republic-of-croatia
#13
Željko Cvetnić, Silvio Špičić, Tomislav Kiš, Maja Zdelar-Tuk, Sanja Duvnjak, Ivana Račić, Miroslav Benić, Boris Habrun, Irena Reil, Zvonimir Šostar
BACKGROUND: Melitococcosis is one of the most widespread zoonoses worldwide. In the period from 2009 to 2013, comprehensive melitococcosis testing was conducted in the Republic of Croatia. METHODS AND RESULTS: During the testing, the Rose Bengal test was applied to 344019 blood samples of sheep and goats, and positive reactions were confirmed in 1143 (0.3%) of samples. The complement fixation test (confirmatory test) was conducted on 43428 samples, with positive reactions confirmed in 768 (1...
December 2014: Psychiatria Danubina
https://www.readbyqxmd.com/read/25468170/antibiotic-treatment-for-6-weeks-versus-12-weeks-in-patients-with-pyogenic-vertebral-osteomyelitis-an-open-label-non-inferiority-randomised-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Louis Bernard, Aurélien Dinh, Idir Ghout, David Simo, Valerie Zeller, Bertrand Issartel, Vincent Le Moing, Nadia Belmatoug, Philippe Lesprit, Jean-Pierre Bru, Audrey Therby, Damien Bouhour, Eric Dénes, Alexa Debard, Catherine Chirouze, Karine Fèvre, Michel Dupon, Philippe Aegerter, Denis Mulleman
BACKGROUND: Duration of treatment for patients with vertebral osteomyelitis is mainly based on expert recommendation rather than evidence. We aimed to establish whether 6 weeks of antibiotic treatment is non-inferior to 12 weeks in patients with pyogenic vertebral osteomyelitis. METHODS: In this open-label, non-inferiority, randomised controlled trial, we enrolled patients aged 18 years or older with microbiologically confirmed pyogenic vertebral osteomyelitis and typical radiological features from 71 medical care centres across France...
March 7, 2015: Lancet
https://www.readbyqxmd.com/read/25420826/prediction-model-to-discard-a-priori-liver-allografts
#15
A Arjona-Sánchez, J M Sánchez-Hidalgo, R Ciria-Bru, F C Muñoz-Casares, J F Ruiz-Rabelo, A Gallardo, R Orti, A Luque, S Rufián-Peña, P López-Cillero, M de la Mata, F J Briceño-Delgado
BACKGROUND: The use of expanded criteria for donors to expand the donor pool has increased the number of discarded liver grafts in situ. The aim of our study was to elaborate a prediction model to reduce the percentage of liver grafts discarded before the procuring team is sent out. METHODS: We analyzed the donor factors of 244 evaluated candidates for liver donation. We performed a multiple logistic regression to evaluate the probability of liver grafts discarded (PD)...
November 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25392479/ectopic-overexpression-of-the-cell-wall-invertase-gene-cin1-leads-to-dehydration-avoidance-in-tomato
#16
Alfonso Albacete, Elena Cantero-Navarro, Dominik K Großkinsky, Cintia L Arias, María Encarnación Balibrea, Roque Bru, Lena Fragner, Michel E Ghanem, María de la Cruz González, Jose A Hernández, Cristina Martínez-Andújar, Eric van der Graaff, Wolfram Weckwerth, Günther Zellnig, Francisco Pérez-Alfocea, Thomas Roitsch
Drought stress conditions modify source-sink relations, thereby influencing plant growth, adaptive responses, and consequently crop yield. Invertases are key metabolic enzymes regulating sink activity through the hydrolytic cleavage of sucrose into hexose monomers, thus playing a crucial role in plant growth and development. However, the physiological role of invertases during adaptation to abiotic stress conditions is not yet fully understood. Here it is shown that plant adaptation to drought stress can be markedly improved in tomato (Solanum lycopersicum L...
February 2015: Journal of Experimental Botany
https://www.readbyqxmd.com/read/25288320/frustrated-expected-reward-induces-differential-transcriptional-changes-in-the-mouse-brain
#17
Elena Martín-García, Noelia Fernández-Castillo, Aurelijus Burokas, Javier Gutiérrez-Cuesta, Cristina Sánchez-Mora, Miguel Casas, Marta Ribasés, Bru Cormand, Rafael Maldonado
Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatable food as reward combined with microarrays. Transcriptomic profiles of frontal cortex, ventral striatum and hippocampus were analysed in five groups of mice: (1) positive control receiving palatable food and the cue light as conditioned stimulus; (2) frustrated group only receiving the cue light; (3) extinction learning group that did not receive palatable food nor the light; (4) negative control that never received the reinforcer nor the light during the whole experiment; and (5) yoked that received palatable food passively...
January 2015: Addiction Biology
https://www.readbyqxmd.com/read/25241220/early-use-of-an-implantable-loop-recorder-in-syncope-evaluation-a-randomized-study-in-the-context-of-the-french-healthcare-system-fresh-study
#18
RANDOMIZED CONTROLLED TRIAL
Cristian Podoleanu, Antoine DaCosta, Pascal Defaye, Jérôme Taieb, Daniel Galley, Paul Bru, Philippe Maury, Philippe Mabo, Serge Boveda, Gilles Cellarier, Frédéric Anselme, Claude Kouakam, Nicolas Delarche, Jean-Claude Deharo
BACKGROUND: The role of implantable loop recorders (ILRs) in the evaluation strategy for recurrent syncope in France is limited by lack of knowledge of the cost. AIM: To compare a conventional evaluation strategy for syncope with the early use of an ILR in low-risk patients, in terms of diagnostic yield, cost and impact on quality of life (QoL). METHODS: National prospective randomized open-label multicenter study of patients with a single syncope (if severe and recent) or at least two syncopes in the past year...
October 2014: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/25236946/single-shot-spinal-anaesthesia-with-hypobaric-bupivacaine-for-hip-fracture-repair-surgery-in-the-elderly-randomized-double-blinded-comparison-of-3-75-mg-vs-7-5-mg
#19
C L Errando, J L Soriano-Bru, C M Peiró, J Ubeda
BACKGROUND: Arterial hypotension is the most frequent adverse effect of subarachnoid anaesthesia in the elderly sustaining a femoral proximal fracture. Decreasing the local anaesthetic dose reduces the incidence of hypotension but shortens sensory block duration that could be insufficient in some surgical procedures. Sensory block duration could be prolonged using hypobaric local anaesthetics. We evaluated whether low hypobaric bupivacaine doses were adequate for this type of surgery while maintaining the haemodynamic stability...
December 2014: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/25234387/predictive-models-for-all-cause-and-cardiovascular-mortality-in-type-2-diabetic-inpatients-a-cohort-study
#20
D Ramírez-Prado, A Palazón-Bru, D M Folgado-de-la Rosa, M Á Carbonell-Torregrosa, A M Martínez-Díaz, V F Gil-Guillén
BACKGROUND: Many authors have analysed premature mortality in cohorts of type 2 diabetic patients, but no analyses have assessed mortality in hospitalised diabetic patients. AIM: To construct predictive models to estimate the likelihood of all-cause mortality and cardiovascular mortality in type 2 diabetic inpatients. DESIGN: Cohort study with follow-up from 2010 to 2014. METHODS: We evaluated mortality in a randomly selected cohort of 112 type 2 diabetic inpatients at the Hospital of Elda (Spain) in 2010-2012...
April 2015: International Journal of Clinical Practice
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