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https://www.readbyqxmd.com/read/29052368/time-course-study-of-long-term-biocompatibility-and-foreign-body-reaction-to-intraneural-polyimide-based-implants
#1
Natàlia de la Oliva, Navarro Xavier, Jaume Del Valle
The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. In order to understand how the FBR to intraneural interfaces evolves, polyimide non-functional devices were implanted in rat peripheral nerve...
October 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29051043/lysyl-oxidase-and-adipose-tissue-dysfunction
#2
Emilie Pastel, Emily Price, Kajsa Sjöholm, Laura J McCulloch, Nikolaj Rittig, Neil Liversedge, Bridget Knight, Niels Moller, Per-Arne Svensson, Katarina Kos
BACKGROUND/OBJECTIVES: Lysyl oxidase (LOX) is an enzyme crucial for collagen fibre crosslinking and thus for fibrosis development. Fibrosis is characterised by a surplus of collagen fibre accumulation and is amongst others also a feature of obesity-associated dysfunctional adipose tissue (AT) which has been linked with type 2 diabetes. We hypothesised that in type 2 diabetes and obesity LOX expression and activity will be increased as a consequence of worsening AT dysfunction. This study aimed to provide a comprehensive characterisation of LOX in human AT...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29050543/granulomatous-necrotizing-myositis-in-swine-affected-by-porcine-circovirus-disease
#3
Guilherme Konradt, Raquel A S Cruz, Daniele M Bassuino, Matheus V Bianchi, Caroline P de Andrade, Fernando S da Silva, David Driemeier, Saulo P Pavarini
Porcine circovirus type 2 (PCV2) is associated with multiple clinical syndromes in pigs, known as porcine circovirus diseases. This work describes an outbreak of porcine circovirus diseases with severe lesions affecting the skeletal muscle. Ninety-two pigs had apathy, weight loss, and diarrhea over a clinical course of 7 to 10 days. Approximately 30 of the pigs had stiff gait, muscle weakness, hind limb paresis, and recumbency. Twelve of the 92 pigs were necropsied, and 4 had pale discoloration of skeletal muscles with microscopic lesions of granulomatous necrotizing myositis...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29049918/dc-sign-expression-in-hofbauer-cells-may-play-an-important-role-in-immune-tolerance-in-fetal-chorionic-villi-during-the-development-of-preeclampsia
#4
Seung Woo Yang, Eun Hee Cho, So Young Choi, Yun Kyung Lee, Jae Hyun Park, Min Kyung Kim, Jin Yeon Park, Hyeong Jwa Choi, Jeong Ik Lee, Hyun Myung Ko, Seung Hwa Park, Han Sung Hwang, Young Sun Kang
Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of maternal mortality in the field of obstetrics, and the innate immunological role of maternal decidual macrophages is well known. In this study, we assessed the differential phenotypes and marker expression in fetal macrophages, known as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)-positive Hofbauer cells...
September 28, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29049011/-omics-of-food-borne-gastroenteritis-global-proteomic-and-mutagenic-analysis-of-salmonella-enterica-serovar-enteritidis
#5
Aryashree Arunima, Soujanya D Yelamanchi, Chandrashekhar Padhi, Sangeeta Jaiswal, Daniel Ryan, Bhawna Gupta, Gajanan Sathe, Jayshree Advani, Harsha Gowda, T S Keshava Prasad, Mrutyunjay Suar
Salmonella Enteritidis causes food-borne gastroenteritis by the two type three secretion systems (TTSS). TTSS-1 mediates invasion through intestinal lining, and TTSS-2 facilitates phagocytic survival. The pathogens' ability to infect effectively under TTSS-1-deficient background in host's phagocytes is poorly understood. Therefore, pathobiological understanding of TTSS-1-defective nontyphoidal Salmonellosis is highly important. We performed a comparative global proteomic analysis of the isogenic TTSS-1 mutant of Salmonella Enteritidis (M1511) and its wild-type isolate P125109...
October 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29046360/a-erk-rsk-mediated-negative-feedback-loop-regulates-m-csf-evoked-pi3k-akt-activation-in-macrophages
#6
Lijun Wang, Caterina Iorio, Kevin Yan, Howard Yang, Sunao Takeshita, Sumin Kang, Benjamin G Neel, Wentian Yang
Activation of the RAS/ERK and its downstream signaling components is essential for growth factor-induced cell survival, proliferation, and differentiation. The Src homology-2 domain containing protein tyrosine phosphatase 2 (SHP2), encoded by protein tyrosine phosphatase, non-receptor type 11 (Ptpn11), is a positive mediator required for most, if not all, receptor tyrosine kinase-evoked RAS/ERK activation, but differentially regulates the PI3K/AKT signaling cascade in various cellular contexts. The precise mechanisms underlying the differential effects of SHP2 deficiency on the PI3K pathway remain unclear...
October 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29046139/immunohistochemical-characterization-of-sarcomas-in-trp53-haploinsufficient-mice
#7
M P Jokinen, D L Morgan, H C Price, R A Herbert, T Saddler, D Dixon
The use of immunohistochemical (IHC) staining in determining and/or confirming the cellular origin of poorly differentiated sarcomas was evaluated in this study. Sarcomatous neoplasms were evaluated in a research study conducted in 2 strains of p53+/- haploinsufficient mice. The most common neoplasms were undifferentiated sarcomas, followed by osteosarcomas and rhabdomyosarcomas (RMSs). The RMSs were poorly differentiated and appeared similar to the pleomorphic, or adult type, RMS of humans. All sarcomas stained positive by IHC for the mesenchymal cell intermediate filament vimentin...
August 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29040215/role-of-receptor-for-advanced-glycation-end-products-in-regulating-lung-fluid-balance-in-lipopolysaccharide-induced-acute-lung-injury-and-infection-related-acute-respiratory-distress-syndrome
#8
Hao Wang, Tao Wang, Zhicheng Yuan, Yufang Cao, Yongfang Zhou, Junyun He, Yongchun Shen, Ni Zeng, Luqi Dai, Fuqiang Wen, Lei Chen
Receptor for advanced glycation end products (RAGE) is implicated in inflammatory responses in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), but its role in pulmonary edema formation remains unclear, especially in infection-related ARDS mainly caused by pneumonia or sepsis. In this study, we investigated the role of RAGE in alveolar fluid regulation by using RAGE gene knockout (RAGE) mice in a murine ALI model induced by lipopolysaccharide (LPS), and by comparing soluble RAGE (sRAGE) levels in serum and bronchial alveolar lavage fluid (BALF) between ARDS patients and control subjects...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/29039651/intracellular-drug-uptake-a-comparison-of-single-cell-measurements-using-tof-sims-imaging-and-quantification-from-cell-populations-with-lc-ms-ms
#9
Carla F Newman, Rasmus Havelund, Melissa K Passarelli, Peter S Marshall, Ian Francis, Andrew West, Morgan Russell Alexander, Ian S Gilmore, Colin T Dollery
ToF-SIMS is a label free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show the method extends to three other cell lines relevant to drug discovery: Human embryonic kidney (HEK293), cervical cancer (HeLa) and liver cancer (HepG2). There is significant interest in the variation of drug uptake at the single cell level and we use ToF-SIMS to show that there is great diversity between individual cells and when comparing each of the cell types...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29039338/anti-inflammatory-and-antiviral-effects-of-water-soluble-crude-extract-from-phragmites-australis-in-vitro
#10
Liqian Zhu, Dong Zhang, Chen Yuan, Xiuyan Ding, Yu Shang, Yuting Jiang, Guoqiang Zhu
Phragmitesaustralis (P. australis), a worldwide distributed wetland grass, is traditionally used as food-making helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS), and the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1β (IL-1β) in RAW264.7 macrophage were significantly inhibited by the crude extract...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29037504/an-investigation-of-virulence-factors-of-legionella-pneumophila-environmental-isolates
#11
Elif Özlem Arslan-Aydoğdu, Ayten Kimiran
Nine Legionella pneumophila strains isolated from cooling towers and a standard strain (L. pneumophila serogroup 1, ATCC 33152, Philadelphia 1) were analyzed and compared in terms of motility, flagella structure, ability to form biofilms, enzymatic activities (hemolysin, nucleases, protease, phospholipase A, phospholipase C, acid phosphatase, alkaline phosphatase and lipase), hemagglutination capabilities, and pathogenicity in various host cells (Acanthamoeba castellanii ATCC 30234, mouse peritoneal macrophages and human peripheral monocytes)...
July 22, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29033935/cannabinoid-receptor-1-participates-in-liver-inflammation-by-promoting-m1-macrophage-polarization-via-rhoa-nf-%C3%AE%C2%BAb-p65-and-erk1-2-pathways-respectively-in-mouse-liver-fibrogenesis
#12
Lei Tian, Weiyang Li, Le Yang, Na Chang, Xiaoting Fan, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li
Macrophage M1/M2 polarization mediates tissue damage and inflammatory responses. Cannabinoid receptor (CB) 1 participated in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation. However, the knowledge of whether CB1 is involved in the polarization of BMMs remains limited. Here, we found M1 gene signatures (including CD86, MIP-1β, tumor necrosis factor, IL-6, and inducible nitric oxide synthase) and the amount of M1 macrophages (CD86(+) cells, gated by F4/80) were significantly elevated in carbon tetrachloride (CCl4)-induced mouse injured livers, while that of M2 type macrophages had little change by RT-qPCR and fluorescence-activated cell sorting (FACS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033131/oxysterol-restraint-of-cholesterol-synthesis-prevents-aim2-inflammasome-activation
#13
Eric V Dang, Jeffrey G McDonald, David W Russell, Jason G Cyster
Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here, we demonstrate that production of 25-hydroxycholesterol (25-HC) by macrophages is required to prevent inflammasome activation by the DNA sensor protein absent in melanoma 2 (AIM2). We find that in response to bacterial infection or lipopolysaccharide (LPS) stimulation, macrophages upregulate Ch25h to maintain repression of SREBP2 activation and cholesterol synthesis...
October 7, 2017: Cell
https://www.readbyqxmd.com/read/29031078/structural-design-synthesis-and-pharmacological-evaluation-of-thiazoles-against-trypanosoma-cruzi
#14
Gevanio Bezerra de Oliveira Filho, Marcos Veríssimo de Oliveira Cardoso, José Wanderlan Pontes Espíndola, Dayane Albuquerque Oliveira E Silva, Rafaela Salgado Ferreira, Pollyanne Lacerda Coelho, Pâmela Silva Dos Anjos, Emanuelle de Souza Santos, Cássio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
Chagas disease is one of the most significant health problems in the American continent. benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and exhibit strong side effects and ineffectiveness in the chronic stage, besides different susceptibility among T. cruzi DTUs (Discrete Typing Units). Therefore, new drugs to treat this disease are necessary. Thiazole compounds have been described as potent trypanocidal agents. Here we report the structural planning, synthesis and anti-T...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29027526/-investigation-of-the-structure-of-a-functionally-intact-xenopericardial-bioconduit-after-long-term-implantation
#15
R A Mukhamadiyarov, N V Rutkovskaya, I V Milto, O D Sidopova, Yu А Kudryavtseva, L S Barbarash
AIM: to investigate the cellular composition of a functionally intact xenopericardial valve in a recipient with acquired mitral defect after long-term implantation. MATERIAL AND METHODS: A Uniline bioconduit (BC) ('Neocor', Kemerovo) removed from the heart in the mitral position at 7.2 years after implantation was investigated. Heart valve leaflets were fixed in a buffered 4% paraformaldehyde solution and imbedded in paraffin or epoxy resin. Slices made from the paraffin samples were stained with hematoxylin and eosin or underwent immunohistochemical (IHC) examination for typing endothelial cells, smooth muscle cells, macrophages, fibroblasts, and T and B lymphocytes...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29026145/cibinetide-dampens-innate-immune-cell-functions-thus-ameliorating-the-course-of-experimental-colitis
#16
Manfred Nairz, David Haschka, Stefanie Dichtl, Thomas Sonnweber, Andrea Schroll, Malte Aßhoff, John E Mindur, Patrizia L Moser, Dominik Wolf, Filip K Swirski, Igor Theurl, Anthony Cerami, Michael Brines, Günter Weiss
Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor cells. In other cell types, including immune cells, EPOR and the ß-common receptor (CD131) form heteromers (the innate repair receptor; IRR), and exert tissue protective effects. We used dextran sulphate sodium (DSS) to induce colitis in C57BL/6 N mice. Once colitis was established, mice were treated with solvent, EPO or the selective IRR agonist cibinetide...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024711/fluoride-potentiates-tubulointerstitial-nephropathy-caused-by-unilateral-ureteral-obstruction
#17
Takamasa Kido, Masashi Tsunoda, Chiemi Sugaya, Hiroshi Hano, Hiroyuki Yanagisawa
The contamination of ground water by fluoride has been reported worldwide. Most fluoride (approximately 70%) is filtered by the kidneys; humans or experimental animals with renal damage therefore may be more affected by fluoride exposure than those with normal kidney function. Tubulointerstitial fibrosis, which involves macrophage-promoted extracellular matrix production and myofibroblast migration, can be induced in rats by unilateral ureteral obstruction (UUO). We examined the effects of fluoride exposure on tubulointerstitial fibrosis in the obstructed kidney of UUO rats...
October 9, 2017: Toxicology
https://www.readbyqxmd.com/read/29024582/photocontrol-of-the-hv1-proton-channel
#18
Andreas Rennhack, Elena Grahn, Benjamin U Kaupp, Thomas K Berger
The voltage-gated proton channel Hv1 is expressed in various human cell types, including macrophages, epithelial cells, and sperm. Hv1 opening leads to proton efflux that alkalizes the cytosol. Here, we describe light-activated Hv1 inhibitors (photoswitches) that allow controlling its activity with high spatiotemporal precision. The photoswitches comprise a light-sensitive azobenzene moiety and 2-guanidinobenzimidazole (2GBI), a known Hv1 inhibitor. In the dark, photoGBI inhibits heterologously expressed Hv1 channels...
October 12, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29023363/lps-induced-systemic-inflammation-does-not-alter-atherosclerotic-plaque-area-or-inflammation-in-apoe3-leiden-mice-in-the-early-phase-up-to-15-days
#19
Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Paul A J Krijnen, Robert Kleemann, Hans W M Niessen, Yvo M Smulders
BACKGROUND AND AIMS: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intra-plaque inflammation. We evaluated whether LPS-evoked acute systemic inflammation would induce such detrimental vascular changes in murine aortas with manifest atherosclerotic lesions. METHODS AND RESULTS: ApoE3*Leiden mice were fed a high cholesterol diet for 20 weeks to establish atherosclerosis...
October 11, 2017: Shock
https://www.readbyqxmd.com/read/29017955/triggering-receptor-expressed-on-myeloid-cells-2-trem-2-expression-tracks-with-m2-like-macrophage-activity-and-disease-severity-in-copd
#20
Derek E Byers, Kangyun Wu, Geoffrey Dang-Vu, Xiaohua Jin, Eugene Agapov, Xiaofeng Zhang, John T Battaile, Kenneth Schechtman, Roger Yusen, Richard A Pierce, Michael J Holtzman
BACKGROUND: Cell and animal models show a key role for Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) in chronic airway disease after viral infection but comparable evidence in humans still needs to be established. METHODS: Lung tissue samples were obtained from lung transplant recipients with GOLD Stage 4 COPD (n=16), non-transplantable donor lung tissues (n=10), and resected lung tissues from at-risk or GOLD Stage 1-4 patients (n=72) and were assessed for TREM-2 and TREM-1 mRNA, protein expression, and other markers of a type 2 immune response...
October 7, 2017: Chest
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