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Broncho alveolar lavage

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https://www.readbyqxmd.com/read/28212817/in-vivo-toxicity-of-copper-oxide-lead-oxide-and-zinc-oxide-nanoparticles-acting-in-different-combinations-and-its-attenuation-with-a-complex-of-innocuous-bio-protectors
#1
Ilzira A Minigalieva, Boris A Katsnelson, Vladimir G Panov, Larisa I Privalova, Anatoly N Varaksin, Vladimir B Gurvich, Marina P Sutunkova, Vladimir Ya Shur, Ekaterina V Shishkina, Irene E Valamina, Ilya V Zubarev, Oleg H Makeyev, Ekaterina Y Meshtcheryakova, Svetlana V Klinova
Stable suspensions of metal oxide nanoparticles (Me-NPs) obtained by laser ablation of 99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in three binary combinations and a triple combination in two independent experiments on rats. In one of the experiments the rats were instilled with Me-NPs intratracheally (i.t.) (for performing a broncho-alveolar lavage in 24hrs to estimate the cytological and biochemical indices of the response of the lower airways), while in the other, Me-NPs were repeatedly injected intraperitoneally (i...
February 14, 2017: Toxicology
https://www.readbyqxmd.com/read/28182749/lack-of-desensitization-of-the-cough-reflex-in-ovalbumin-sensitized-rabbits-during-exercise
#2
Angelica Tiotiu, Bruno Chenuel, Laurent Foucaud, Bruno Demoulin, Silvia Demoulin-Alexikova, Christo Christov, Mathias Poussel
INTRODUCTION: Cough is a major symptom of asthma frequently experienced during exercise but little is known about interactions between cough and exercise. The goal of our study was to clarify the potential modulation of the cough reflex (CR) by exercise in a spontaneously breathing anaesthetized animal model of airway eosinophilic inflammation. MATERIALS & METHODS: Ten ovalbumin (OVA) sensitized adult rabbits and 8 controls were studied. The ventilatory response to direct tracheal stimulation, performed both at rest and during exercise was determined to quantify the incidence and the sensitivity of the CR...
2017: PloS One
https://www.readbyqxmd.com/read/28115263/investigation-of-viral-infection-in-idiopathic-pulmonary-fibrosis-among-iranian-patients-in-tehran
#3
Pouya Moradi, Hossein Keyvani, Seyed-Ali Javad Mousavi, Mohammad Hadi Karbalaie Niya, Maryam Esghaei, Farah Bokharaei-Salim, Angila Ataei-Pirkooh, Seyed Hamidreza Monavari
AIM OF THE STUDY: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, which can be lethal with chronic complications. Viral infections may be associated with IPF and other fibrotic lung diseases. In the present study, we investigate for the first time in Iran the related viral etiology of IPF in order to detect three respiratory viruses; human adenovirus, enterovirus and bocavirus. MATERIALS AND METHODS: In this cross-sectional study which was supported by Iran University of Medical Sciences, Tehran, Iran...
January 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28108365/neutrophil-subset-responses-in-infants-with-severe-viral-respiratory-infection
#4
Bart Cortjens, Sarah A Ingelse, Job C Calis, Alexander P Vlaar, Leo Koenderman, Reinout A Bem, Job B van Woensel
Neutrophils are the predominant inflammatory cells recruited to the respiratory tract as part of the innate immune response to viral infections. Recent reports indicate the existence of distinct functional neutrophil subsets in the circulatory compartment of adults, following severe inflammatory conditions. Here, we evaluated the occurrence of neutrophil subsets in blood and broncho-alveolar lavage fluid during severe viral respiratory infection in infants based on CD16/CD62L expression. We show that during the course of severe respiratory infection infants may develop four heterogeneous neutrophil subsets in blood (mature, immature, progenitor, and suppressive neutrophils), each with distinct activation states...
January 17, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28095804/pulmonary-manifestations-in-niemann-pick-type-c-disease-with-mutations-in-npc2-gene-case-report-and-review-of-literature
#5
Jayesh Sheth, Jijo John Joseph, Krati Shah, Mamta Muranjan, Mehul Mistri, Frenny Sheth
BACKGROUND: Niemann-Pick disease type C (NPC) is an inherited metabolic disorder; due to defect in cellular cholesterol trafficking. It is clinically a heterogeneous disease with variable age of onset with multiple organ systems being involved. NPC1 gene is involved in 95% cases where as remaining ~5% cases are linked with NPC2 gene. CASE PRESENTATION: Case-1, a 14-months-old female presented with recurrent respiratory distress, failure to thrive and hepatosplenomegaly...
January 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28063900/smoker-extracellular-vesicles-influence-status-of-human-bronchial-epithelial-cells
#6
Amélie Héliot, Yann Landkocz, Françoise Roy Saint-Georges, Pierre Gosset, Sylvain Billet, Pirouz Shirali, Dominique Courcot, Perrine J Martin
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns. Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes...
December 30, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28063043/subcutaneous-and-sublingual-immunotherapy-in-a-mouse-model-of-allergic-asthma
#7
Laura Hesse, Martijn C Nawijn
Allergic asthma, caused by inhaled allergens such as house dust mite or grass pollen, is characterized by reversible airway obstruction, associated with an eosinophilic inflammation of the airways, as well as airway hyper responsiveness and remodeling. The inhaled allergens trigger a type-2 inflammatory response with involvement of innate lymphoid cells (ILC2) and Th2 cells, resulting in high production of immunoglobulin E (IgE) antibodies. Consequently, renewed allergen exposure results in a classic allergic response with a distinct early and late phase, both resulting in bronchoconstriction and shortness of breath...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28049200/a-mouse-model-of-post-stroke-pneumonia-induced-by-intra-tracheal-inoculation-with-streptococcus-pneumoniae
#8
Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp
BACKGROUND: Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke...
January 4, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28043506/drug-resistance-pattern-of-mycobacterium-tuberculosis-in-the-province-with-highest-incidence-of-tuberculosis-in-iran
#9
N Mansoori, Masoumeh Douraghi, F Vaziri, A A Rajabloo, M Sheikhi, M Taziki, M Atarjalali
OBJECTIVE/BACKGROUND: Incidence of tuberculosis (TB) in Golestan Province is consistently higher than other provinces of Iran. This study aimed to determine the rate of drug resistance to first-line antibiotics in Mycobacterium tuberculosis (MTB) isolates recovered from new cases in this province. METHODS: The sputum and broncho-alveolar lavage samples from 3828 patients who were suspected for active TB were collected from March 2015 to July 2015. All specimens were subjected to smear microscopy and culture...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042058/eosinophilic-airway-inflammation-in-asthma-is-associated-with-an-altered-airway-microbiome
#10
Asger Sverrild, Pia Kiilerich, Asker Brejnrod, Rebecca Pedersen, Celeste Porsbjerg, Anders Bergqvist, Jonas S Erjefält, Karsten Kristiansen, Vibeke Backer
BACKGROUND: Subjects with asthma have higher microbiome diversity, and an altered composition with more Proteobacteria and less Bacteroidetes compared to healthy controls. Studies comparing airway inflammation and airway microbiome are sparse, especially in subjects not on anti-inflammatory treatment. OBJECTIVE: To describe the relationship between the airway microbiome and patterns of airway inflammation in steroid-free subjects with asthma and healthy controls...
December 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28039243/electrical-impedance-tomography-for-non-invasive-assessment-of-stroke-volume-variation-in-health-and-experimental-lung-injury
#11
C J C Trepte, C Phillips, J Solà, A Adler, B Saugel, S Haas, S H Bohm, D A Reuter
BACKGROUND: Functional imaging by thoracic electrical impedance tomography (EIT) is a non-invasive approach to continuously assess central stroke volume variation (SVV) for guiding fluid therapy. The early available data were from healthy lungs without injury-related changes in thoracic impedance as a potentially influencing factor. The aim of this study was to evaluate SVV measured by EIT (SVVEIT) against SVV from pulse contour analysis (SVVPC) in an experimental animal model of acute lung injury at different lung volumes...
January 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27992536/broncho-alveolar-dendritic-cells-and-macrophages-are-highly-similar-to-their-interstitial-counterparts
#12
Pauline Maisonnasse, Elise Bordet, Edwige Bouguyon, Nicolas Bertho
In human medicine, bronchoalveolar lavage is the main non-traumatic procedure allowing an insight into the respiratory Dendritic Cells (DC) and Macrophages populations. However, it has never been demonstrated in a relevant model that alveolar DC subpopulations were comparable to their interstitial counterparts. In a precedent work we observed that respiratory pig DC and Macrophages were more similar to the human ones than to the mouse ones. In the present work, thanks to our animal model, we were able to collect the rare bronchoalveolar DC and compare them to their interstitial counterparts...
2016: PloS One
https://www.readbyqxmd.com/read/27942183/saprochaete-capitata-fungal-infection-in-renal-transplant-recipient
#13
S Mandarapu, V Krishna, S B Raju, U Pamidimukkala, S Nimmagadda
Saprochaete capitata is a fungus that rarely causes human infections; majority of infections were reported in patients with hematological malignancies. Here, we report a case of Saprochaete capitata infection in a renal transplant recipient. To the best of our knowledge, this is the first case report of infection with this unusual organism in renal transplant recipients. In our patient, this organism was isolated from broncho alveolar lavage, and it responded dramatically to the combination of amphotericin and voriconazole...
November 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27863396/p2rx4-deficiency-in-mice-alleviates-allergen-induced-airway-inflammation
#14
Andreas Zech, Benjamin Wiesler, Cemil Korcan Ayata, Tilmann Schlaich, Thorsten Dürk, Madelon Hoßfeld, Nicolas Ehrat, Sanja Cicko, Marco Idzko
Compelling evidences point out a crucial role for extracellular nucleotides such as adenosine triphosphate (ATP) during inflammatory conditions. Once released into the extracellular space, ATP modulates migration, maturation and function of various inflammatory cells via activating of purinergic receptors of the P2Y- and P2X- family. P2RX4 is an ATP-guided ion channel expressed on structural cells such as alveolar epithelial and smooth muscle cells as well as inflammatory cells including macrophages, dendritic cells (DCs) and T cells...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27805632/x-ray-based-lung-function-measurement-a-sensitive-technique-to-quantify-lung-function-in-allergic-airway-inflammation-mouse-models
#15
C Dullin, M A Markus, E Larsson, G Tromba, S Hülsmann, F Alves
In mice, along with the assessment of eosinophils, lung function measurements, most commonly carried out by plethysmography, are essential to monitor the course of allergic airway inflammation, to examine therapy efficacy and to correlate animal with patient data. To date, plethysmography techniques either use intubation and/or restraining of the mice and are thus invasive, or are limited in their sensitivity. We present a novel unrestrained lung function method based on low-dose planar cinematic x-ray imaging (X-Ray Lung Function, XLF) and demonstrate its performance in monitoring OVA induced experimental allergic airway inflammation in mice and an improved assessment of the efficacy of the common treatment dexamethasone...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27803427/yellow-broncho-alveolar-lavage-fluid-in-eosinophilic-pneumonia
#16
Daijiro Nabeya, Takeshi Kinjo, Kazuya Miyagi, Jiro Fujita
No abstract text is available yet for this article.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27801920/hydralazine-induced-anca-vasculitis-in-the-setting-of-acute-clostridium-difficile-infection
#17
Somwail Rasla, Amr El Meligy, Dragos F Cucu
We report a rare case of Hydralazine-induced ANCA associated glomerulonephritis with alveolar hemorrhage in the setting of acute Clostridium Difficile Infection. A 71-year-old Caucasian woman with hypertension, who was being treated with hydralazine 25 mg twice a day for six years, presented to the hospital with diarrhea, nausea, vomiting and anemia. She had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. She was found to have Clostridium difficile colitis which was successfully treated...
November 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27798704/the-influenza-virus-protein-pb1-f2-increases-viral-pathogenesis-through-neutrophil-recruitment-and-nk-cells-inhibition
#18
Aurore Vidy, Pauline Maisonnasse, Bruno Da Costa, Bernard Delmas, Christophe Chevalier, Ronan Le Goffic
The influenza A virus (IAV) PB1-F2 protein is a virulence factor contributing to the pathogenesis observed during IAV infections in mammals. In this study, using a mouse model, we compared the host response associated with PB1-F2 with an early transcriptomic signature that was previously associated with neutrophils and consecutively fatal IAV infections. This allowed us to show that PB1-F2 is partly involved in neutrophil-related mechanisms leading to death. Using neutropenic mice, we confirmed that the harmful effect of PB1-F2 is due to an excessive inflammation mediated by an increased neutrophil mobilization...
2016: PloS One
https://www.readbyqxmd.com/read/27795667/chronic-ethanol-exposure-effects-on-vitamin-d-levels-among-subjects-with-alcohol-use-disorder
#19
Olalekan Ogunsakin, Tete Hottor, Ashish Mehta, Maureen Lichtveld, Michael McCaskill
Vitamin D has been previously recognized to play important roles in human immune system and function. In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37. Human cathelicidin/LL-37 is a bactericidal, bacteriostatic, and antiviral endogenous peptide with protective immune functions. Chronic exposure to excessive alcohol has the potential to reduce levels of vitamin D (inactive vitamin D [25(OH)D3] and active vitamin D [1, 25(OH)2D3]) and leads to downregulation of cathelicidin/LL-37...
2016: Environmental Health Insights
https://www.readbyqxmd.com/read/27756605/liraglutide-attenuates-lipopolysaccharide-induced-acute-lung-injury-in-mice
#20
Feng Zhou, Ying Zhang, Jing Chen, Xuemei Hu, Yancheng Xu
Liraglutide, an effective drug for the treatment of diabetes, has been proven to demonstrate anti-inflammatory and immunomodulatory effects. Hence, this study explored the effects and mechanism of action of liraglutide on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Male BALB/c mice were pre-conditioned with liraglutide or saline prior to intraperitoneal LPS or saline administration. Histopathological examination of lung, the wet/dry (W/D)weight ratio, protein content, inflammatory cell numbers and pro-inflammatory cytokine levels in broncho-alveolar lavage fluid (BAL fluid) were conducted...
November 15, 2016: European Journal of Pharmacology
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