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https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#1
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29233791/incidental-anterior-mediastinal-nodular-lesions-on-chest-ct-in-asymptomatic-subjects
#2
Soon Ho Yoon, Seung Ho Choi, Chang Hyun Kang, Jin Mo Goo
HYPOTHESIS: To investigate the prevalence and characteristics of nodular lesions in the anterior mediastinum that had been incidentally found on screening chest CT in asymptomatic subjects. METHODS: We included 56,358 consecutive participants (mean age, 52.4±10.5 years; male-female, 35,306:21,052) who underwent a baseline low-dose chest CT scan for health checkups from 2006 through 2013. After confirming the presence of anterior mediastinal nodular lesion, their CT findings, confirmatory diagnosis and interval CT scan were reviewed...
December 9, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29221349/ab-thymoma-with-atypical-type-a-component-with-delayed-multiple-lung-and-brain-metastases
#3
Wieslawa Grajkowska, Ewa Matyja, Jacek Kunicki, Sylwia Szymanska, Alexander Marx, Cleo-Aron Weis, Renata Langfort, Malgorzata Szolkowska
An atypical type A thymoma is a newly added entity to the last World Health Organization (WHO) histological classification [2015] of uncertain prognosis. The conventional type A and AB thymomas are usually locally aggressive neoplasms that rarely metastasize with distant metastases to the central nervous system (CNS) occurring extremely exceptionally. We present a history of a woman with a mediastinal tumor originally considered to be a Masaoka-Koga stage II "mixed thymoma with well-differentiated thymic carcinoma component" according to the historic Müller-Hermelink nomenclature...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221334/minimally-invasive-multi-disciplinary-approach-for-surgical-management-of-a-mediastinal-congenital-bronchogenic-cyst-in-a-6-month-old-infant
#4
Xiao-Hua Li, Tao Zhang, Sheng Wang, Biao-Chuan He, Xue-Ning Yang, Wen-Zhao Zhong, Ji-Mei Chen
We present a case of prenatal diagnosis of a mediastinal cyst by ultrasound, confirmed during infancy through computed tomography (CT) and magnetic resonance imaging (MRI). A 6-month-old male infant was admitted to the hospital. A mid-mediastinal cyst was detected through a province-wide fetal ultrasonography screening program. During the infancy stage, the CT scan and the MRI confirmed the finding of a mediastinal cyst. Based on the findings on prenatal ultrasonography and postnatal imaging studies (CT, MRI), a benign mediastinal cyst was suspected...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221229/tracking-occult-pn2-disease-after-mediastinal-dissection-in-early-stage-lung-cancer
#5
EDITORIAL
Cristiano Benato, Sara Pilotto, Maurizio Infante, Emilio Bria
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221225/mediastinal-lymph-node-dissection-in-surgical-treatment-for-early-stage-non-small-cell-lung-cancer-lobe-specific-or-systematic
#6
EDITORIAL
Hiroyuki Adachi, Takamitsu Maehara, Haruhiko Nakayama, Munetaka Masuda
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217088/induction-cisplatin-docetaxel-followed-by-surgery-and-erlotinib-in-non-small-cell-lung-cancer
#7
Tina Cascone, Kathryn A Gold, Stephen G Swisher, Diane D Liu, Frank V Fossella, Boris Sepesi, Apar Pataer, Annikka Weissferdt, Neda Kalhor, Ara A Vaporciyan, Wayne L Hofstetter, Ignacio I Wistuba, John V Heymach, Edward S Kim, William N William
BACKGROUND: Data from meta-analyses support the use of induction or adjuvant platinum-based chemotherapy for locally advanced non-small cell lung cancers (NSCLCs). This phase 2 study assessed the role of induction cisplatin and docetaxel followed by surgery in patients with resectable stage I to III NSCLCs, followed by 12 months of adjuvant erlotinib. METHODS: Patients with resectable stage I to III NSCLCs received cisplatin 80 mg/m2, docetaxel 75 mg/m2 every 21 days for 3 cycles, followed by surgery, followed by adjuvant erlotinib for 12 months...
December 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29201483/purulent-appearing-material-in-an-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-node-a-diagnostic-challenge
#8
Damaris Pena, Gilda Diaz-Fuentes, Sindhaghatta Venkatram
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has increasingly been performed for the diagnosis and staging of thoracic malignancies. Findings of a necrotic lymph node raise concern for infectious process and malignancy. A hypoechoic area on ultrasound/EBUS within a lymph node without blood flow is suggestive of pathologies like infections or malignancy. Inspection of the fluid could suggest a diagnosis; clear aspirates usually suggest bronchogenic or mediastinal cysts and purulent material suggests abscesses or necrotic lymph nodes...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29201451/neuroendocrine-tumors-of-the-thymus
#9
REVIEW
Pier Luigi Filosso, Enrico Ruffini, Paolo Solidoro, Matteo Roffinella, Paolo Olivo Lausi, Paraskevas Lyberis, Alberto Oliaro, Francesco Guerrera
Primary neuroendocrine tumors of the thymus (NETTs) are rare and biologically very aggressive neoplasms, usually located in the anterior mediastinal space. They are more frequently observed in males, in their fourth/fifth decades of life. In 50% of cases, NETTs are associated with endocrinopaties [Cushing's syndrome, acromegaly or Multiple Endocrine Neoplasia-1 (MEN-1) syndrome]. NETTs very often present with invasion of the surrounding mediastinal anatomical structures. Surgery, even in advanced stages, is the mainstay of treatment: a compete resection through a median sternotomy or a combined access (sternotomy + thoracotomy) should be always attempted...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29200146/successful-treatment-of-mediastinal-%C3%AE-%C3%AE-t-cell-lymphoblastic-lymphoma-in-a-3-year-old-girl-by-allogeneic-cord-blood-transplantation
#10
Daiki Hori, Ryoji Kobayashi, Daisuke Suzuki, Hirozumi Sano, Nobutaka Kiyokawa, Kunihiko Kobayashi
A 3-year-old girl presenting with a huge mediastinal tumor and massive pleural effusion, was diagnosed with stage III γδ T-cell lymphoblastic lymphoma (γδ T-LBL) by flow cytometry of effusion cells. Four courses of chemotherapy achieved complete remission, and 5/6 HLA allele-matched cord blood transplantation was performed with success. The patient remains in first complete remission >16 months after transplantation. γδ T-LBL is very rare, especially that of mediastinal origin, and is acknowledged as having an extremely poor clinical outcome...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29199667/mediastinal-staging-for-non-small-cell-lung-cancer-revisited-it-is-being-done-under-aegis-of-icon-and-lung-cancer-consortium-asia
#11
REVIEW
D Pandey, P Ramanathan, R Pandey, K Prabhash
Mediastinal staging is a crucial factor in the decision making in patients with non-metastatic non-small cell lung cancer (NSCLC). Mediastinoscopy has historically been the gold standard for this purpose. With the advent of PET-CT, the role of an invasive staging modality like mediastinoscopy has been diminishing. Newer developments in endoscopic staging like EBUS and EUS-FNA have also provided means to get a cytological diagnosis of enlarged lymph nodes. With the meta-analyses showing encouraging results of neoadjuvant chemotherapy in operable lung cancers including the early stage disease, the sanctity of invasive mediastinal staging for the sole purpose for selecting patients for upfront surgery is debatable...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198623/thoracoscopic-surgery-versus-thoracotomy-for-lung-cancer-short-term-outcomes-of-a-randomized-trial
#12
Hao Long, Qunyou Tan, Qingquan Luo, Zheng Wang, Gening Jiang, Dongrong Situ, Yongbin Lin, Xiaodong Su, Qing Liu, Tiehua Rong
BACKGROUND: Safety and short-term efficacy of video-assisted thoracoscopic surgery (VATS) for early-stage non-small lung cancer (NSCLC) has been demonstrated by observational studies previously. However, these outcomes have never been verified by a large randomized controlled trial (RCT). The aim of our RCT was to confirm that VATS is not inferior or even superior to open operation for early-stage NSCLC in terms of short-term and oncologic efficacy. METHODS: The trial was undertaken at five tertiary hospitals...
December 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29197400/evaluation-of-the-new-tnm-staging-system-for-thymic-malignancies-impact-on-indication-and-survival
#13
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Zsolt Sziklavari, Hans-Stefan Hofmann
BACKGROUND: The objective of this study is the evaluation of the Masaoka-Koga and the International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancy Interest Group (ITMIG) proposal for the new TNM-staging system on clinical implementation and prognosis of thymic malignancies. METHODS: A retrospective study of 76 patients who underwent surgery between January 2005 and December 2015 for thymoma. Kaplan-Meier survival analysis was used to determine overall and recurrence-free survival rates...
December 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29195613/interim-fdg-pet-imaging-in-lymphoma
#14
REVIEW
Andrea Gallamini, Colette Zwarthoed
In the present article, the authors reviewed the rationale of FDG-PET/CT performed at an interim time point during therapy (iPET), focusing on the transition from standard, anatomical assessment of tumor shrinkage with CT to document a chemotherapy response, to the use of functional imaging with PET to assess chemosensitivity of the individual tumor. The prognostic or predictive role of iPET in different lymphoma subsets has been reviewed, with particular emphasis on early and advanced-stage Hodgkin lymphoma, diffuse large B-cell lymphoma, peripheral T-cell lymphoma, extranodal natural killer/T-cell lymphoma, and primary mediastinal B-cell lymphoma...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29191583/wolf-in-sheep-s-clothing-primary-lung-cancer-mimicking-benign-entities
#15
REVIEW
Annemie Snoeckx, Amélie Dendooven, Laurens Carp, Damien Desbuquoit, Maarten J Spinhoven, Patrick Lauwers, Paul E Van Schil, Jan P van Meerbeeck, Paul M Parizel
Lung cancer is the most common cancer worldwide. On imaging, it typically presents as mass or nodule. Recognition of these typical cases is often straightforward, whereas diagnosis of uncommon manifestations of primary lung cancer is far more challenging. Lung cancer can mimic a variety of benign entities, including pneumonia, lung abscess, postinfectious scarring, atelectasis, a mediastinal mass, emphysema and granulomatous diseases. Correlation with previous history, clinical and biochemical parameters is necessary in the assessment of these cases, but often aspecific and inconclusive...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29190998/radiological-and-nuclear-medicine-imaging-of-sarcoidosis
#16
Anna R Larici, Andor W Glaudemans, Annemilia Del Ciello, Riemer H Slart, Lucio Calandriello, Olivier Gheysens
Sarcoidosis is a multisystem chronic inflammatory disease of unknown etiology characterized by widespread growth of non-caseating granulomas. The diagnosis of sarcoidosis is based on clinical and imaging presentation, histologic confirmation and the absence of alternative diseases. Radiology and Nuclear Medicine play an essential role in the diagnostic work-up of patients with sarcoidosis to assess disease extent and activity. In addition, imaging modalities have shown their potential in managing these patients in terms of treatment response and prognostic assessment...
November 30, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29179511/the-role-of-endobronchial-ultrasound-elastography-in-the-diagnosis-of-mediastinal-and-hilar-lymph-nodes
#17
Ye Gu, Hong Shi, Chunxia Su, Xiaoxia Chen, Shijia Zhang, Wei Li, Fengying Wu, Guanghui Gao, Hao Wang, Haiqing Chu, Caicun Zhou, Fei Zhou, Shengxiang Ren
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been widely used for diagnosis and mediastinal lymph nodes staging in patients with suspicious lung cancer. Ultrasound elastography is a novel sonographical technique that can evaluate tissue compressibility. The aim of the present study was to investigate the diagnostic yield of elastography for differentiating malignant and benign mediastinal lymph nodes. Conventional EBUS B-mode features, including size, shape, border distinction, echogenicity, central hilar structure with central blood vessel and coagulation necrosis were also evaluated...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29174661/anesthetic-considerations-for-mediastinal-staging-procedures-for-lung-cancer
#18
REVIEW
J P Cata, J Lasala, G E Mena, J R Mehran
Tumor staging is critical for the treatment of lung malignancies. Invasive techniques of lung tumor staging can be accomplished via mediastinoscopy, endobronchial ultrasound, and video-assisted thoracoscopy. Anesthesiologists taking care of patients undergoing mediastinal staging procedures might face different challenges. In this narrative review, the authors summarize the literature on the anesthetic considerations for mediastinal staging procedures.
September 21, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29173765/esophageal-ultrasound-eus-assessment-of-t4-status-in-nsclc-patients
#19
Jolanda C Kuijvenhoven, Laurence Crombag, David P Breen, Inge van den Berk, Michel I M Versteegh, Jerry Braun, Toon A Winkelman, Wimjan van Boven, Peter I Bonta, Klaus F Rabe, Jouke T Annema
BACKGROUND: Mediastinal and central large vessels (T4) invasion by lung cancer is often difficult to assess preoperatively due to the limited accuracy of computed tomography (CT) scan of the chest. Esophageal ultrasound (EUS) can visualize the relationship of para-esophageally located lung tumors to surrounding mediastinal structures. AIM: To assess the value of EUS for detecting mediastinal invasion (T4) of centrally located lung tumors. METHODS: Patients who underwent EUS for the diagnosis and staging of lung cancer and in whom the primary tumor was detected by EUS and who subsequently underwent surgical- pathological staging (2000-2016) were retrospectively selected from two university hospitals in The Netherlands...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29163656/the-usefulness-of-thoracic-ultrasonography-in-diagnosis-and-staging-of-bronchogenic-carcinoma
#20
Manal R Hafez, Eman Sm Sobh, Sawsan B Elsawy, Omaima I Abo-Elkheir
Aim: To evaluate (1) the usefulness of thoracic ultrasound in diagnosis and staging of bronchogenic carcinoma by comparing lesion detectability between thoracic- ultrasound and computed tomography and (2) the outcome of thoracic-ultrasound-guided biopsy in diagnosing bronchogenic carcinoma. Methods: We conducted a cross-sectional study on 53 patients of confirmed bronchogenic carcinoma. All patients had been investigated by thoracic-ultrasound and chest-computed tomography; data regarding the presence of mass (its size, necrosis), lymph nodes invasion, peritumoural atelectasis, consolidations, pleural effusion, chest wall invasion, and paralysis of the diaphragm were recorded...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
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