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https://www.readbyqxmd.com/read/28431716/invasive-medullary-type-a-thymoma-with-recurrent-distant-metastases
#1
Maria Cecilia Mengoli, Lucia Longo, Susanna Varini, Giulio Rossi, Filippo Lococo
Thymomas are rare epithelial mediastinal tumors showing a certain propensity for local and intrathoracic recurrences. Otherwise, extrathoracic metastases are very rarely reported and are usually associated with type B thymomas or thymic carcinomas. We present a challenging patient with an invasive (Masaoka-Koga stage IIb) medullary type A thymoma with recurrent extrathoracic metastases (pulmonary and vertebral localizations occurring 2 and 7 years after the initial radical thymectomy, respectively). Despite type A thymoma being considered a low-grade malignancy with a scarce propensity to recurrence, the present case should alert clinicians to the possibility of bone metastasis...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28426673/lymph-node-volume-predicts-survival-but-not-nodal-clearance-in-stage-iiia-iiib-nsclc
#2
Vishesh Agrawal, Thibaud P Coroller, Ying Hou, Stephanie W Lee, John L Romano, Elizabeth H Baldini, Aileen B Chen, David Kozono, Scott J Swanson, Jon O Wee, Hugo J W L Aerts, Raymond H Mak
BACKGROUND: Locally advanced non-small cell lung cancer (LA-NSCLC) patients have poorer survival and local control with mediastinal node (N2) tumor involvement at resection. Earlier assessment of nodal burden could inform clinical decision-making prior to surgery. This study evaluated the association between clinical outcomes and lymph node volume before and after neoadjuvant therapy. MATERIALS AND METHODS: CT imaging of patients with operable LA-NSCLC treated with chemoradiation and surgical resection was assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28424839/reirradiation-of-recurrent-node-positive-non-small-cell-lung-cancer-after-previous-stereotactic-radiotherapy-for-stage%C3%A2-i-disease-a%C3%A2-multi-institutional-treatment-recommendation
#3
Carsten Nieder, Dirk De Ruysscher, Laurie E Gaspar, Matthias Guckenberger, Minesh P Mehta, Patrick Cheung, Arjun Sahgal
BACKGROUND: Practice guidelines have been developed for early-stage and locally advanced non-small cell lung cancer (NSCLC). However, many common clinical scenarios still require individualized decision making. This is true for locoregional relapse after initial stereotactic radiotherapy (stereotactic body radiation therapy or stereotactic ablative radiotherapy; SBRT or SABR), an increasingly utilized curative treatment option for stage I NSCLC. METHODS: A consortium of expert radiation oncologists was established with the aim of providing treatment recommendations...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28415982/the-treatment-of-primary-mediastinal-large-b-cell-lymphoma-a-two-decades-monocentric-experience-with-98-patients
#4
Alessandro Broccoli, Beatrice Casadei, Vittorio Stefoni, Cinzia Pellegrini, Federica Quirini, Lorenzo Tonialini, Alice Morigi, Miriam Marangon, Lisa Argnani, Pier Luigi Zinzani
BACKGROUND: The purpose of this study is to investigate the most suitable first-line approach and the best combination treatment for primary mediastinal large B-cell lymphoma (PMLBCL) as they have been matter of debate for at least two decades. METHODS: Our single centre experience in the treatment of 98 de novo PMLBCL patients over the last 20 years is reviewed. All patients received MACOP-B chemotherapy. Thirty-seven received both rituximab and mediastinal radiotherapy; 30 were irradiated after chemotherapy, although not receiving rituximab and 20 received rituximab without radiotherapy consolidation...
April 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28415687/the-prognostic-impact-of-supraclavicular-lymph-node-in-n3-iiib-stage-non-small-cell-lung-cancer-patients-treated-with-definitive-concurrent-chemo-radiotherapy
#5
Dongryul Oh, Yong Chan Ahn, Hee Chul Park, Do Hoon Lim, Jae Myoung Noh, Won Kyung Cho, Hongryull Pyo
BACKGROUND: This study aimed to investigate the prognostic impact of supraclavicular lymph node (SCN) metastasis in patients who were treated with definitive chemoradiotherapy for N3-IIIB stage non-small cell lung cancer (NSCLC). RESULTS: The 2- and 5-year overall survival (OS) rates were 57.3% and 35.7% in patients without SCN metastasis and 56.4% and 26.7% in patients with SCN metastasis, respectively. The median OS was 34 months in both groups. There was no significant difference in OS between the two groups (p = 0...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402455/stage-i-non-small-cell-lung-cancer-long-term-results-of-lobectomy-versus-sublobar-resection-from-the-polish-national-lung-cancer-registry%C3%A2
#6
Robert Dziedzic, Wojciech Zurek, Tomasz Marjanski, Piotr Rudzinski, Tadeusz M Orlowski, Wioletta Sawicka, Michal Marczyk, Joanna Polanska, Witold Rzyman
OBJECTIVES: Anatomical lobar resection and mediastinal lymphadenectomy remain the standard for the treatment of early stage non-small-cell lung cancer (NSCLC) and are preferred over procedures such as segmentectomy or wedge resection. However, there is an ongoing debate concerning the influence of the extent of the resection on overall survival. The aim of this article was to assess the overall survival for different types of resection for Stage I NSCLC. METHODS: We performed a retrospective analysis of the results of the surgical treatment of Stage I NSCLC...
April 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28400111/endobronchial-ultrasound-in-invasive-mediastinal-staging-a%C3%A2-method-for-all-seasons
#7
EDITORIAL
Biniam Kidane
No abstract text is available yet for this article.
March 10, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28399376/evaluation-of-appropriate-mediastinal-staging-among-ebus-bronchoscopists
#8
Russell J Miller, Lakshmi Mudambi, Macarena R Vial, Mike Hernandez, George A Eapen
RATIONALE: Endobronchial ultrasound (EBUS) has transformed mediastinal staging in lung cancer. A systematic approach, beginning with lymph nodes contralateral to the primary tumor (N3), is considered superior to selective sampling of radiographically abnormal nodes. However, the extent to which this recommendation is followed in practice remains unknown. OBJECTIVES: To assess the frequency in which pulmonologists, pulmonary fellows, and interventional pulmonologists endoscopically stage lung cancer appropriately...
April 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28386749/safety-and-feasibility-of-thoracoscopic-esophagectomy-after-neoadjuvant-chemotherapy-for-esophageal-cancer
#9
Yushi Fujiwara, Shigeru Lee, Satoru Kishida, Ryoya Hashiba, Ken Gyobu, Masashi Takemura, Harushi Osugi
PURPOSE: Neoadjuvant chemotherapy (NAC) with cisplatin and fluorouracil is the recommended standard treatment for resectable locally advanced esophageal cancer (EC) in Japan. We investigated the effects of NAC on the safety and feasibility of thoracoscopic esophagectomy with total mediastinal lymphadenectomy for EC. METHODS: This retrospective study analyzed data from 225 consecutive patients who underwent thoracoscopic esophagectomy with lymph node dissection between April 2007 and December 2015...
April 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28386210/re-evaluation-of-the-role-of-thoracoscopic-esophagectomy-as-a-japanese-style-radical-surgery
#10
Harushi Udagawa, Masaki Ueno, Shusuke Haruta, Tsuyoshi Tanaka, Aya Mizuno, Yu Ohkura
PURPOSE: To investigate the value of thoracoscopic surgery in radical esophagectomy with three-field lymphadenectomy. MATERIALS AND METHOD: The subjects were 329 consecutive patients who, without preoperative chemoradiotherapy, underwent R0 radical esophagectomy with three-field lymphadenectomy for thoracic squamous cell esophageal cancers during 1998-2013. Open thoracotomy was applied in 212 (O), and thoracoscopic surgery in 117 (V). Survivals according to TNM Stages and Efficacy index (EI) were analyzed...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28384959/thoracic-sarcoidosis-imaging-with-high-resolution-computed-tomography
#11
Peeyush Kumar Dhagat, Sarvinder Singh, Megha Jain, Satyendra Narayan Singh, Rajat Kumar Sharma
INTRODUCTION: Sarcoidosis is a disease of unknown aetiology that primarily affects the lungs. Clinical and radiological findings with demonstration of non caseating granulomas on pathology is utilised for diagnosing the disease. AIM: To assess and evaluate the features of thoracic sarcoidosis on High Resolution Computed Tomography (HRCT) chest. MATERIALS AND METHODS: A total of 40 (31 males and 9 females) cases of pulmonary sarcoidosis in a period of three years were included in this study...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28378140/management-of-non-hodgkin-lymphoma-icmr-consensus-document
#12
Nirav Thacker, Sameer Bakhshi, Girish Chinnaswamy, Tushar Vora, Maya Prasad, Deepak Bansal, Sandeep Agarwala, Gauri Kapoor, Venkatraman Radhakrishnan, Siddharth Laskar, Tanvir Kaur, G K Rath, Rupinder Singh Dhaliwal, Brijesh Arora
Hitherto poor outcomes, paucity of data and heterogeneity in International approach to Pediatric NHL (Non-Hodgkin Lymphoma) prompted the need for guidelines for Indian population with vast variability in access, affordability and infrastructure across the country. These guidelines are based on consensus among the experts and best available evidence applicable to Indian setting. Evaluation of NHL should consist of easily doable and rapid tissue diagnosis (biopsy or flow cytometry of peripheral blood/malignant effusions), St Jude/IPNHLSS (International Pediatric Non-Hodgkin Lymphoma Staging System) and risk grouping with CSF (Cerebro-spinal fluid), bone marrow, whole body imaging [CECT (Contrast enhanced computerized tomography) ± MRI (Magnetic resonance imaging)] and blood investigations for LDH (Lactate dehydrogenase), TLS (Tumor lysis syndrome) and organ functions...
April 5, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28375941/two-tumors-in-1-what-should-be-the-therapeutic-target-pediatric-germ-cell-tumor-with-somatic-malignant-transformation
#13
Cecile Faure Conter, Brice Fresneau, Estelle Thebaud, Amandine Bertrand, Frederique Dijoud, Angelique Rome, Cecile Dumesnil, Marie Pierre Castex, Anguella Ghanem, Daniel Orbach
BACKGROUND: Germ cell tumors with somatic malignant transformation (GCT with SMT) are rare in children and poorly described. Data are missing to determine if therapies should target the GCT, the SMT compound, or both simultaneously. PATIENTS AND METHODS: A retrospective national study was conducted in the Société Française des cancers de l'Enfant (SFCE) Centers. Medical records from patients aged 0 to 18 years diagnosed with GCT with SMT between 2000 and 2015 were analyzed...
April 3, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28366663/recurrent-stroke-due-to-metastatic-pulmonary-tumor-emboli-as-an-important-clinical-entity
#14
Junji Takasugi, Manabu Sakaguchi, Naoki Oyama, Yasufumi Gon, Yasukazu Terasaki, Tsutomu Sasaki, Susumu Nakahara, Kenji Ohshima, Yumiko Hori, Eiichi Morii, Hideki Mochizuki
We present an autopsy case of repetitive stroke due to tumor emboli, indistinguishable from thromboembolism with a hypercoagulable state in its clinical course. A 72-year-old man diagnosed with stage IVA oropharyngeal squamous cell carcinoma received chemoradiotherapy. Follow-up imaging revealed mediastinal lymph nodes and pulmonary metastasis. One year later, the patient experienced right arm weakness, and brain magnetic resonance imaging showed acute ischemic lesions in multiple vascular territories. He was diagnosed with paradoxical cerebral embolism due to cancer-associated venous thrombosis and treated with rivaroxaban...
March 30, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28366464/prognostic-value-of-national-comprehensive-cancer-network-lung-cancer-resection-quality-criteria
#15
Raymond U Osarogiagbon, Meredith A Ray, Nicholas R Faris, Matthew P Smeltzer, Carrie Fehnel, Cheryl Houston-Harris, Raymond S Signore, Laura M McHugh, Paul Levy, Lynn Wiggins, Vishal Sachdev, Edward T Robbins
BACKGROUND: The National Comprehensive Cancer Network (NCCN) surgical resection guidelines for non-small cell lung cancer recommend anatomic resection, negative margins, examination of hilar/intrapulmonary lymph nodes, and examination of three or more mediastinal nodal stations. We examined the survival impact of these criteria. METHODS: A population-based observational study was done using patient-level data from all curative-intent, non-small cell lung cancer resections from 2004 to 2013 at 11 institutions in four contiguous Dartmouth Hospital referral regions in three US states...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28364180/combined-small-cell-lung-carcinoma-and-giant-cell-carcinoma-a-case-report
#16
Tomohito Saito, Koji Tsuta, Kento J Fukumoto, Hiroshi Matsui, Toshifumi Konobu, Yoshitaro Torii, Takashi Yokoi, Takayasu Kurata, Hiroaki Kurokawa, Yoshiko Uemura, Yukihito Saito, Tomohiro Murakawa
BACKGROUND: Combined small cell lung carcinoma (SCLC) is defined as SCLC combined with elements of non-small cell lung carcinoma (NSCLC), accounting for approximately 30% of cases of SCLC. However, combined SCLC and giant cell carcinoma (GC) is very rare. CASE PRESENTATION: A 50-year-old woman with a 45 pack-year smoking history was referred to our hospital for further investigation of an abnormal left hilar shadow. Chest computed tomography (CT) revealed a 28-mm solid pulmonary nodule in the left lower lobe and an enlarged left hilar lymph node adjacent to the left main pulmonary artery...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28356749/adrenalectomy-does-not-improve-survival-rates-of-patients-with-solitary-adrenal-metastasis-from-non-small-cell-lung-cancer
#17
Shao-Hong Huang, Qing-Lei Kong, Xue-Xia Chen, Jin-Yuan He, Jie Qin, Zhuang-Gui Chen
BACKGROUND AND PURPOSE: Several case reports and studies have suggested that there is an increased survival rate for patients who undergo resection of solitary adrenal metastasis from non-small cell lung cancer (NSCLC). This study aimed to investigate whether NSCLC patients with solitary adrenal metastasis could gain a higher survival rate after adrenalectomy (ADX) when compared with those patients undergoing nonsurgical treatment, and to investigate the potential prognostic factors. PATIENTS AND METHODS: A total of 1,302 NSCLC inpatients' data from 2001 to 2015 were retrospectively reviewed to identify those with solitary adrenal metastasis...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28341037/influenza-virus-infection-exacerbates-experimental-autoimmune-encephalomyelitis-disease-by-promoting-type-i-t-cells-infiltration-into-central-nervous-system
#18
Qingyun Chen, Yinping Liu, Aizhen Lu, Ke Ni, Zheng Xiang, Kun Wen, Wenwei Tu
Multiple sclerosis starts with increased migration of auto-reactive lymphocytes across the blood-brain barrier, resulting in persistent neurodegeneration. Clinical and epidemiological studies indicated upper respiratory viral infections are associated with clinical exacerbation of multiple sclerosis. However, so far there is no any direct evidence to support it. Using the experimental autoimmune encephalomyelitis mice as the model for multiple sclerosis, we demonstrated that mice experienced with influenza virus infection were unable to recover from experimental autoimmune encephalomyelitis with a long-term exacerbation...
February 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28331834/ultrasound-guided-electrochemotherapy-for-the-treatment-of-a-clear-cell-thymoma-in-a-cat
#19
Enrico Pierluigi Spugnini, Francesco Menicagli, Michela Pettorali, Alfonso Baldi
A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (ECT) using systemic bleomycin...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28324142/a-phase-ii-study-of-partial-and-subtotal-thymectomy-for-thymoma-jart02
#20
Motoki Yano, Yoshitaka Fujii, Junji Yoshida, Tomoki Utsumi, Hiroyuki Shiono, Motoshi Takao, Masayuki Tanahashi, Yushi Saito
BACKGROUND: We believe the merit of preservation of a part of the thymus following surgery for thymoma. We evaluated the efficacy of partial or subtotal thymectomy for early-stage thymoma in the prospective study. METHODS: The Japanese Association for Research on the Thymus conducted a multiple institutional study of thymectomy for thymoma localized in the thymus without total thymectomy. Patients without autoimmune disease who had an anterior mediastinal tumor that had been clinically diagnosed as an early-stage thymoma were enrolled in the study...
March 21, 2017: World Journal of Surgery
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