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Mediastinal staging

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https://www.readbyqxmd.com/read/27914192/accuracy-and-consequences-of-same-day-invasive-lung-cancer-workup-a-retrospective-study-in-patients-treated-with-surgical-resection
#1
Kirsten Riis Madsen, Asbjørn Høegholm, Uffe Bodtger
BACKGROUND: Though widely used, little is known about accuracy and efficacy of same-day, invasive workup of suspected lung cancer. OBJECTIVE: To evaluate the accuracy and efficacy of same-day, invasive lung cancer workup (diagnosis and mediastinal staging), and to identify differences between patients without (Group A) or with (Group B) need for resampling. METHODS: A retrospective study was performed on all consecutive patients referred for surgical treatment for localised lung cancer after invasive diagnostic and staging workup at our unit...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#2
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27909271/-epidermal-growth-factor-receptor-mutated-advanced-lung-adenocarcinoma-with-long-term-tumor-free-survival-by-chemotherapy-followed-by-tyrosine-kinase-inhibitor-treatment-after-reduction-surgery
#3
Atsushi Morio, Kazuki Nakahara, Toshirou Futagawa, Kenji Suzuki
A 67-year-old woman was detected stage III B adenocarcinoma of the left lung, with epidermal growth factor receptor(EGFR) -mutation. Since chest computed tomography showed enlarged lymph nodes in stations 7 and 1R-4R, radiochemotherapy was recommended. However, she declined radiochemotherapy and the chemotherapy after tumor reduction surgery was chosen. She underwent resection of the left lower lobe and lingular segment, and mediastinal lymph node dissection through a posterolateral thoracotomy by extended bronchoplasty(type C) due to the extranodal invasion of lymph nodes to the lingular segmental bronchus...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27902779/differential-cytokine-gene-expression-in-granulomas-from-lungs-and-lymph-nodes-of-cattle-experimentally-infected-with-aerosolized-mycobacterium-bovis
#4
Mitchell V Palmer, Tyler C Thacker, W Ray Waters
The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Factors within the granulomas such as cytokines and chemokines drive cell recruitment, activity, function and ultimately the success or failure of the host's ability to control infection...
2016: PloS One
https://www.readbyqxmd.com/read/27899784/-effectiveness-of-carboplatin-plus-taxane-chemotherapy-for-advanced-or-recurrent-uterine-serous-carcinoma
#5
Takuto Matsuura, Isao Otsuka
OBJECTIVE: Uterine serous carcinoma(USC)is more aggressive compared to endometrioid adenocarcinoma, and often exhibits intraperitoneal spread, resulting in a poor prognosis. It is a rare subtype of uterine cancers, accounting for 5%of cases in Japan; therefore, optimal chemotherapy regimens for patients with advanced or recurrent disease have not been established. In the present study, we evaluated the safety and efficacy of carboplatin plus taxane chemotherapy for the treatment of patients withadvanced and recurrent USC...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27895343/cervical-mediastinoscopy-in-the-diagnosis-of-lymphadenopathy-in-south-asia
#6
Sulaiman Bashir Hasan, Fazal Wahab Khan, Shiraz Hashmi, Ahsan Ehtesham, Rizwana Ahmed Magsi, Syed Shahabuddin
We planned to determine the clinical utility and safety of mediastinoscopy in the pathologic diagnosis of mediastinal lymphadenopathy and to determine disease patterns in a tertiary care setting in Karachi. The retrospective review comprised record of patients who underwent mediastinoscopy over 25 years between July, 1990 and August, 2015. Of the 122 patients, records were complete for 88(72%). Mean age was 42.5±12.9 years and 55(62.5%) were male. Overall, 60(68.2%) patients had benign inflammatory diseases; 25 (28...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27884195/lymph-node-ratio-as-a-prognostic-factor-in-patients-with-pathological-n2-non-small-cell-lung-cancer
#7
Masaya Tamura, Isao Matsumoto, Daisuke Saito, Shuhei Yoshida, Munehisa Takata, Hirofumi Takemura
BACKGROUND: The aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC). METHODS: A total of 182 patients were diagnosed with pathological N2 disease and underwent complete resection surgeries with systematic lymphadenectomies. We counted the number of positives and removed lymph nodes to calculate a ratio between them (LNR)...
November 25, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27876071/bilateral-single-port-thoracoscopic-extended-thymectomy-for-management-of-thymoma-and-myasthenia-gravis-case-report
#8
Francesco Paolo Caronia, Alfonso Fiorelli, Ettore Arrigo, Sebastiano Trovato, Mario Santini, Attilio Ignazio Lo Monte
BACKGROUND: Video-assisted thoracoscopy is become a widely accepted approach for the resection of anterior mediastinal masses, including thymoma. The current trend is to reduce the number of ports and minimize the length of incisions to further decrease postoperative pain, chest wall paresthesia, and length of hospitalization. Herein, we reported an extended resection of thymoma in a patient with myasthenia gravis through an uniportal bilateral thoracoscopic approach. CASE PRESENTATION: A 74 years old woman with myasthenia gravis was referred to our attention for management of a 3...
November 22, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#9
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27870565/concurrent-chemotherapy-and-radiation-therapy-for-inoperable-locally-advanced-non-small-cell-lung-cancer
#10
Kenneth E Rosenzweig, Jorge E Gomez
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866679/-hodgkin-and-non-hodgkin-lymphoma-of-adolescents-and-young-adults
#11
REVIEW
Sylvain Garciaz, Diane Coso, Pauline Brice, Réda Bouabdallah
Lymphoma is one of the most frequent cancers in adolescent and young adults. Hodgkin Lymphoma is curable in more than 90% of cases. Recent pediatric and adults protocols aimed to decrease long term toxicities (mostly gonadic and cardiovascular) and secondary malignancies, reducing the use of alkylating agents and limiting radiation fields. Risk-adapted strategies, using positron emission tomography staging, are about to become a standard, both in adult and pediatric protocols. These approaches allow obtaining excellent results in adolescents with Hodgkin lymphoma...
November 17, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27866516/-gsi-quantitative-parameters-preoperative-diagnosis-of-metastasis-lymph-nodes-in-lung-cancer
#12
Fengfeng Yang, Jie Dong, Xiaolong Yan, Xiuting Wang, Xiaojiao Fu, Tong Zhang
BACKGROUND: Mediastinal involvement in lung cancer is an important prognostic factor affecting survival, and accurate staging of the mediastinum lymph node correctly identifies patients who can benefit the most from surgery. The aim of this study is to investigate the value of dual-energy spectral computed tomography (DEsCT) imaging in differentiating metastatic from non-metastatic lymph nodes in lung cancer. METHODS: Forty-eight patients with non-small cell lung cancer (NSCLC) underwent arterial (AP) and portal venous (PP) phase contrast-enhanced DEsCT imaging followed by surgical treatment...
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27865476/endobronchial-and-endoscopic-ultrasound-guided-transvascular-biopsy-of%C3%A2-mediastinal-hilar-and-lung-lesions
#13
Jordan Kazakov, Pravachan Hegde, Mehdi Tahiri, Vicky Thiffault, Pasquale Ferraro, Moishe Liberman
BACKGROUND: Endoscopic techniques, including endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS), are the initial approach for the diagnosis and staging of lung cancer and the diagnosis of mediastinal and hilar lesions. Historically, the transvascular approach has been avoided because of concerns of bleeding. Here we review our experience with EBUS and EUS transvascular biopsy of mediastinal, hilar, and lung lesions. METHODS: A prospective research database was used to retrospectively identify and review the records 33 consecutive patients who underwent EBUS and EUS transvascular biopsy in an outpatient setting over 4 years...
November 16, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27862032/pleural-drop-metastases-21-years-after-resection-of-a-thymoma
#14
Chia-Chun Chiang, Angela M Parsons, J Scott Kriegshauser, Harshita R Paripati, Matthew A Zarka, A Arturo Leis
INTRODUCTION: We describe an unusual case of pleural drop metastases 21 years after complete resection of an encapsulated thymoma in a Southeast Asian with myasthenia gravis (MG). METHODS: Case report and review of literature. RESULTS: The patient presented in 2015 with generalized weakness, fatigue, and shortness of breath, but no diplopia, ptosis, dysphagia, or dysarthria. Because these symptoms were atypical for an MG exacerbation, a de novo work-up was performed...
November 16, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27861398/ratio-of-lymph-node-to-primary-tumor-suvmax-multiplied-by-maximal-tumor-diameter-on-positron-emission-tomography-integrated-computed-tomography-may-be-a-predictor-of-mediastinal-lymph-node-malignancy-in-lung-cancer
#15
Yi Liu, Yanhua Tang, Zhiqiang Xue, Ping Yang, Kefeng Ma, Guangyu Ma, Xiangyang Chu
Positron emission tomography/integrated computed tomography (PET/CT) provides the most accurate imaging modality for preoperative lung cancer staging. However, the diagnostic accuracy of maximum standardized uptake value (SUVmax) for mediastinal (N2) lymph nodes (LN) is unclear. We compared SUVmax, the ratio of LN to primary tumor SUVmax (SUVn/t), and SUVn/t multiplied by maximal tumor diameter (SUVindex) in terms of their abilities to predict mediastinal LN malignancy.We retrospectively analyzed 170 mediastinal LN stations from 73 consecutive patients who underwent systemic LN resection and PET/CT within 27 days...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27860078/pulmonologist-performed-transoesophageal-sampling-for-lung-cancer-staging-using-an-endobronchial-ultrasound-videobronchoscope-an-australian-experience
#16
Hari Wimaleswaran, Michael W Farmer, Louis B Irving, Barton R Jennings, Daniel P Steinfort
BACKGROUND: Transoesophageal endobronchial ultrasound (EBUS) video-bronchoscope insertion provides pulmonologists access to conduct endoscopic fine-needle aspiration (EUS-B-FNA) of mediastinal lymph node (LN) lesions and also assist in lung cancer staging by sampling left adrenal gland (LAG) lesions. Limited literature have described additional diagnostic value, whilst maintaining patient safety. METHODS: All eligible patients with paraoesophageal lesions on thoracic computed tomography (CT) underwent pulmonologist-performed EUS-B-FNA at two tertiary centres and were included in this prospective observational cohort study...
November 16, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27855672/nut-midline-carcinoma-mimicking-a-germ-cell-tumor-a-case-report
#17
Yohei Harada, Takafumi Koyama, Kengo Takeuchi, Kazufusa Shoji, Kazuei Hoshi, Yu Oyama
BACKGROUND: NUT midline carcinoma (NMC) is a rare and highly aggressive malignancy. Although more information on NMC has been recently accumulating in the literature, most oncologists and pathologists remain unfamiliar with the clinical and pathologic features of this disease. The clinical features of NMC sometimes mimic those of other malignancies, and NMC can therefore be overlooked if the diagnosis is not suspected. We present the case of a young male with NMC arising in the mediastinum with elevated serum alpha-fetoprotein levels suggestive of an extragonadal nonseminomatous germ-cell tumor...
November 17, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27854541/what-exactly-is-a-centrally-located-lung-tumor-results-of-an-on-line-survey
#18
Roberto F Casal, Macarena R Vial, Russell Miller, Lakshmi Mudambi, Horiana B Grosu, George A Eapen, Carlos A Jimenez, Rodolfo C Morice, Lorraine Cornwell, David Ost
RATIONALE: Accurate mediastinal staging is cornerstone in the management of patients with lung cancer. For patients with radiographically normal mediastinum, current lung cancer guidelines recommend invasive mediastinal staging when tumors are centrally located. However, definitions of central tumors are non-specific and there are discrepancies among guidelines (e.g. some use the inner one third of the hemithorax while others use the inner two thirds). OBJECTIVES: To describe the definitions of central tumors used by pulmonologists and thoracic surgeons in their practice...
November 17, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27847082/slow-growing-mediastinal-grey-zone-lymphoma-originating-from-a-formerly-resected-multilocular-thymic-cyst
#19
Rie Tabata, Chiharu Tabata, Yoshitane Tsukamoto, Masaki Hashimoto, Ryoji Yasumizu, Masaru Kojima
We report a unique case of mediastinal grey zone lymphoma that was considered to originate from CD20(+)CD30(+) Hodgkin cell-like cells associated with a multilocular thymic cyst that had been completely removed 4 years previously. In the formerly resected thymus, irregular-shaped cysts were observed, and large CD20(+)CD30(+) Hodgkin cell-like cells proliferated in close association with the proliferating thymic epithelial cells. This case suggests the important role of thymic columnar epithelial cells in the proliferation of thymic B cells and the tumorigenesis of mediastinal grey zone lymphoma...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27833322/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-rare-case-of-carcinoma-stomach-with-concomitant-silicosis
#20
Arun Sasikumar, Ajith Joy, Madhavan Unni, Jayaprakash Madhavan
The role of fluorine-18 fluorodeoxyglucose. ((18)F-FDG) positron emission tomography. (PET)/computed tomography. (CT) in the initial staging of various malignancies is now well established. However, nonspecificity of FDG occasionally results in tracer uptake in benign lung lesions. The authors describe a complicated case of carcinoma stomach with multiple nodules and a cavitary lesion in lungs where (18)F-FDG PET CT done for initial staging revealed FDG avid mass in stomach, FDG avid multiple mediastinal lymph nodes and multiple intensely FDG avid bilateral lung lesions...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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