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Mediastinal staging

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https://www.readbyqxmd.com/read/29675060/utility-and-safety-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-patients-with-mediastinal-and-hilar-lymphadenopathy-western-region-experience
#1
Ahmed A Aljohaney
AIMS: The aim of the study was to evaluate the clinical utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with mediastinal and hilar lymphadenopathy and to explicitly describe the utility of this procedure in patient's outcome. METHODS: A retrospective review and analysis was conducted on 52 patients with mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA from June 2012 to June 2016. All the patients were evaluated by computed tomography (CT) chest with contrast before EBUS examination...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29673728/infrahyoid-involvement-may-be-a-high-risk-factor-in-the-management-of-non-odontogenic-deep-neck-infection-retrospective-study
#2
Hui Yuan, Rong Gao
OBJECTIVES: This study sought to investigate the impact of involvement of the infrahyoid neck space on the management of non-odontogenic DNI. METHOD: Eighty-one patients treated for non-odontogenic DNI over 5 years were retrospectively recruited into this study. Demographics, etiology, radiology results, treatments, duration/cost of hospital stay, and complications were recorded. Differences between DNIs with and without infrahyoid involvement, as defined based on an anatomical chart, were analyzed...
March 16, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29666816/surgical-approach-in-oligometastatic-non-small-cell-lung-cancer
#3
REVIEW
Davide Patrini, Nikolaos Panagiotopoulos, Benedetta Bedetti, Sofoklis Mitsos, Roberto Crisci, Piergiorgio Solli, Luca Bertolaccini, Marco Scarci
The vast majority of lung cancer (80%) are non-small cell lung cancer (NSCLC) presenting in huge proportion of patients in a metastatic stage at the time of diagnosis with an overall survival (OS) of only 6 months. Standard treatment at this stage involves systemic platinum based chemotherapy improving the OS for only few months. For the vast majority of patients disease progression occurs and cure cannot achieved. An exception to this general rule is represented by patients with a limited number of metastasis (approximately 7% of patients with metastatic NSCLC): in 1995 Hellman and Weichselbaum introduced the term "oligometastatic" for a selected group of patients with metastatic disease...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666815/endobronchial-ultrasound-transbronchial-needle-aspiration-ebus-tbna-a-diagnostic-challenge-for-mediastinal-lesions
#4
REVIEW
Duilio Divisi, Gino Zaccagna, Mirko Barone, Francesca Gabriele, Roberto Crisci
Lung cancer is one of the most frequent neoplastic diseases. To date, most lung cancer is diagnosed at an advanced stage, making it difficult to choose the diagnostic and therapeutic strategy. Surgical resection represents the best therapeutic solution. However, the best results are obtained only in the early stages of the disease. Lymph node involvement conditions the treatment (surgical or non-surgical approach). Mediastinoscopy is an effective and widely used method for mediastinal staging but does not allow us to reach many mediastinal lymph nodes...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29665940/-advances-in-the-molecular-diagnosis-and-therapy-of-relapsed-refractory-diffuse-large-b-cell-lymphoma-review
#5
Yi Wang, Bing Xia, Yi-Zhuo Zhang
Diffuse large B-cell lymphoma (DLBCL) is biologically aggressive and most common pathological type of non-Hodgkin's lymphoma (NHL), and about one-third of these patients are refractory or relapsed ultimately. Based on the molecular heterogeneity, DLBCL can be divided into 3 main molecular subtypes: germinal center B-cell like (GCB), activated B-cell like (ABC) and primary mediastinal B-cell lymphoma (PMBL). Arising from B cells at distinct stages of differentiation, these subtypes are also diverse in mechanisms of oncogenic activation...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29664842/incidental-thoracic-findings-on-routine-computed-tomography-in-epithelial-ovarian-cancer
#6
Bobby D OʼLeary, Teresa Treacy, Tony Geoghegan, Tom A Walsh, William D Boyd, Donal J Brennan
INTRODUCTION: Multidetector computed tomography (MDCT) is routinely used in the surveillance of epithelial ovarian cancer. The aim of this study was to determine the incidence of thoracic findings on routine MDCT surveillance imaging in patients with ovarian carcinoma. MATERIALS AND METHODS: Retrospective evaluation of 100 MDCT studies of patients with a diagnosis of epithelial ovarian cancer was performed at a university teaching hospital. The cross-sectional studies were reviewed by a consultant radiologist with subspeciality training in cross-sectional imaging...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29664358/tailored-management-of-stage-iiia-non-small-cell-lung-cancer-in-the-era-of-the-8th-edition-of-the-tnm-classification-for-lung-cancer
#7
Michael R Mueller
Stage IIIA is a very heterogeneous group encompassing locally advanced disease with T3 and T4 tumors without any nodal involvement and very small T1a primary tumors with unilateral mediastinal lymphatic disease. Tailored management defines interdisciplinary management requiring board decisions, which can sometimes be difficult particularly in stage IIIa non-small-cell lung cancer (NSCLC). Lobectomy still is standard of care even for stage I NSCLC, which increasingly is implemented using minimally invasive surgical technique...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29655961/chimeric-antigen-receptor-t-cell-therapy-for-non-hodgkin-lymphoma
#8
REVIEW
Armin Ghobadi
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy. More than 20,000 people in United States, more than 37,000 people in Europe and more than 199,000 people worldwide die of NHL every year. Recent advances in immunotherapeutic approaches for cancer have resulted in development of new classes of very effective immunotherapeutic approaches including chimeric antigen receptor T (CAR-T) cell therapy that are designed to bypass cancer immune evasion. Here, we review recent advances in CAR-T cell therapy for NHL...
April 11, 2018: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29627400/unusual-diagnoses-made-by-convex-probe-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#9
S Fernandez-Bussy, H Inaty, I Caviedes, G Labarca, M R Vial, A Majid
Endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) has proven to be an effective and minimally invasive tool to diagnose and stage lung cancer. However, its use for the diagnosis of rare mediastinal and lung pathologies has been rarely described. Hereby we describe a retrospective chart review of our EBUS-TBNA database for unusual diagnosis made between July 2012 and October 2016. Those conditions considered unusual for EBUS-TBNA diagnosis were identified and their medical records reviewed...
April 4, 2018: Pulmonology
https://www.readbyqxmd.com/read/29622075/staging-lung-cancer-regional-lymph-node-classification
#10
REVIEW
Ahmed H El-Sherief, Charles T Lau, Brett W Carter, Carol C Wu
This article reviews regional lymph node assessment in lung cancer. In the absence of a distant metastasis, the absence or location of lung cancer spread to a regional mediastinal lymph node affects treatment options and prognosis. Regional lymph node maps have been created to standardize assessment of the N descriptor. The International Association for the Study of Lung Cancer lymph node map is used for the standardization of N descriptor assessment. CT, PET/CT with fluorodeoxyglucose, endobronchial ultrasound-guided and/or esophageal ultrasound-guided biopsy, and mediastinoscopy are common modalities used to determine the N descriptor...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29615010/malignant-pleural-mesothelioma-diagnostic-value-of-medical-thoracoscopy-and-long-term-prognostic-analysis
#11
Li-Li Xu, Yuan Yang, Zhen Wang, Xiao-Juan Wang, Zhao-Hui Tong, Huan-Zhong Shi
BACKGROUND: Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and many factors associated with poor prognosis of MPM. We conducted this study to investigate the value of MT for diagnosing of MPM and to identify prognostic factors for MPM patients. METHODS: From July 2005 through June 2014, a total of 833 patients with undiagnosed pleural effusions underwent MT and pleural biopsies were taken...
April 3, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29610732/thoracic-perforations-surgical-techniques
#12
REVIEW
Atilla Eroglu, Yener Aydin, Omer Yilmaz
Esophageal perforation may occur spontaneously, iatrogenically or in connection with traumas. Sepsis may develop in connection with mediastinal and pleural exposure in a very short time as a consequence of disintegration of the esophagus. Esophageal perforation is an emergency accompanied with a high level of mortality and morbidity. Rate of mortality for the perforations in the thoracic region is higher than that in the cervical and abdominal regions. Delay in diagnosis and treatment is the most important factor to affect the mortality...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29607396/prevalence-and-echo-features-of-mediastinal-lymph-nodes-in-eus-for-non-malignant-indications-a-prospective-study-in-a-southern-european-population
#13
Joana Carmo, Miguel Bispo, Susana Marques, Cristina Chagas
Background and study aims:  Significant heterogeneity in geographic distribution regarding the prevalence of mediastinal lymph nodes (MLN) has been documented in autopsy and computed tomography (CT) studies. Awareness of the local prevalence and characteristics of lymph nodes will be relevant when performing endoscopic ultrasonography (EUS) for staging of malignant neoplasias. The aims of this study were to document the prevalence and echo features of MLN in patients undergoing EUS for non-malignant extrathoracic disease and to identify predictive factors for the presence of MLN...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29607394/diagnostic-adequacy-and-safety-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-patients-with-lymphadenopathy-in-a-large-cohort
#14
Rinkesh K Bansal, Narendra S Choudhary, Saurabh K Patle, Mahesh K Gupta, Chitranshu Vashishtha, Gagandeep Kaur, Haimanti Sarin, Rajesh Puri
Background and study aims : The role of endoscopic-ultrasound (EUS) guided fine-needle aspiration (FNA) in patients with lymphadenopathy in terms of diagnostic adequacy and safety in large population is not well defined. The aim of this study was to evaluate diagnostic adequacy and safety of EUS-FNA in patients with lymphadenopathy. Patients and methods:  Retrospective study from October 2010 to September 2015 at tertiary care center in Delhi-NCR. We analyzed data from 1005 EUS- FNAs of lymph nodes...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29605962/ten-years-experience-in-robotic-assisted-thoracic-surgery-for-early-stage-lung-cancer
#15
Monica Casiraghi, Domenico Galetta, Alessandro Borri, Adele Tessitore, Rosalia Romano, Cristina Diotti, Daniela Brambilla, Patrick Maisonneuve, Lorenzo Spaggiari
BACKGROUND:  This study analyzed the short- and long-term outcomes of robotic-assisted thoracic surgery (RATS) for early stage non-small cell lung cancer (NSCLC). METHODS:  From November 2006 to December 2016, we performed 363 RATS procedures. This study retrospectively reviewed 339 patients who underwent RATS for clinical stages I ( n  = 318) or II ( n  = 21) NSCLC. RESULTS:  Twenty-nine patients underwent segmentectomy, 307 lobectomy, and 3 pneumonectomy...
April 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29601559/-advances-in-endoscopic-diagnosis-of-sarcoidosis
#16
REVIEW
Anna Filarecka, Maciej Gnass, Anna Obrochta, Sylwia Szlubowska, Piotr Kocoń, Damian Czyżewski, Juliusz Pankowski, Artur Szlubowski
A diagnosis of pulmonary sarcoidosis is based on the assessment of clinical outcome, radiology findings and detection of noncaseating granulomas in cytology or histology specimens. Cytological material obtained from enlarged lymph nodes and/or histological specimens from bronchial mucosa and lung tissue are examined according to sarcoidosis stage. The most available are standard bronchoscopic methods as conventional transbronchial needle aspiration (cTBNA), endobronchial biopsy (EBB) and transbronchial lung biopsy (TBLB) both performed with use of forceps...
March 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29600085/current-role-of-standardized-uptake-value-max-derived-ratios-in-n2-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-non-small-cell-lung-cancer
#17
REVIEW
Duilio Divisi, Mirko Barone, Roberto Crisci
Mediastinal staging is a crucial moment in management of non-small cell lung cancer (NSCLC) patients. In integrated pathways, 18-fluorine fluorodeoxyglucose positron-emission tomography (18 F-FDG-PET/CT) is an indispensable imaging resource with its peculiarities and its limitations. A critical review of work up protocols would certainly help to standardize procedures with important reflections also on the diagnostic value of this examination. In this regard, new semi-quantitative and semi-qualitative indexes have been proposed with the aim of increasing the accuracy of 18 F-FDG-PET/CT in mediastinal lymph node staging...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29596820/patterns-of-practice-in-mediastinal-lymph-node-staging-for-non-small-cell-lung-cancer-in-canada
#18
Simon R Turner, Nazgol Seyednejad, Basil S Nasir
BACKGROUND: Assessment of mediastinal lymph nodes is integral in staging patients with non-small cell lung cancer (NSCLC). This study aims to delineate the lymph node staging practices of Canadian thoracic surgeons in patients with potentially resectable NSCLC. METHODS: A questionnaire was distributed to Canadian Association of Thoracic Surgeons members (n=86). Items addressed the use of imaging, thresholds/methods for preoperative invasive staging, and intraoperative node staging...
March 26, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29587940/-exploration-of-postoperative-follow-up-strategies-for-early-staged-nsclc-patients-on-the-basis-of-follow-up-result-of-416-stage-i-nsclc-patients-after-lobectomy
#19
Liang Dai, Wanpu Yan, Xiaozheng Kang, Hao Fu, Yongbo Yang, Haitao Zhou, Zhen Liang, Hongchao Xiong, Yao Lin, Keneng Chen
BACKGROUND: Currently, there is no consensus on the follow-up strategy (follow-up time interval and content) of non-small cell lung cancer (NSCLC) in the world, and the relevant clinical evidence is also very limited. In this study, we aimed to summarize the recurrence/metastasis sites and timings of stage I NSCLC patients based on their follow-up data, aiming to provide a basis of follow-up time interval and content for this group of patients. METHODS: We retrospectively analyzed the 416 stage I NSCLC patients that underwent continuous anatomic lobectomy between Jan...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29587908/-to-explore-clinical-value-of-single-port-video-assisted-thoracoscopic-surgery-in-elderly-patients-with-non-small-cell-lung-cancer-lobectomy-segmentectomy-and-lobectomy-vs-segmentectomy
#20
Lin Huang, Bin Zheng, Chun Chen, Wei Zheng, Yong Zhu, Chaohui Guo
BACKGROUND: The morbidity of lung cancer has long been the highest in cancer. Stage I, stage II and partly of stage III non-small cell lung cancer (NSCLC) are mainly treated by surgery. Lobectomy and segmentectomy both are common lung resection methods. Video-assisted thoracoscopic surgery (VATS) has been widely used in clinical, and the application of single-portvideo-assisted thoracoscopic surgery (SP VATS) has gradually been recognized and accepted by professors. With increasing degree of eldly in society, eldly patients already have become inceasingly difficulties in the diagnosis and treatment of NSCLC...
April 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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