keyword
https://read.qxmd.com/read/38530556/multidisciplinary-approach-for-locally-advanced-non-small-cell-lung-cancer-nsclc-2023-expert-consensus-of-the-spanish-lung-cancer-group-gecp
#1
REVIEW
Aylen Vanessa Ospina, Sergio Bolufer Nadal, José Luis Campo-Cañaveral de la Cruz, Jose Luis González Larriba, Ivan Macía Vidueira, Bartomeu Massutí Sureda, Ernest Nadal, Florentino Hernando Trancho, Antonio Álvarez Kindelán, Edel Del Barco Morillo, Reyes Bernabé Caro, Joaquim Bosch Barrera, Virginia Calvo de Juan, Joaquin Casal Rubio, Javier de Castro, Ángel Cilleruelo Ramos, Manuel Cobo Dols, Manuel Dómine Gómez, Santiago Figueroa Almánzar, Rosario Garcia Campelo, Amelia Insa Mollá, José Ramón Jarabo Sarceda, Unai Jiménez Maestre, Rafael López Castro, Margarita Majem, Alex Martinez-Marti, Elisabeth Martínez Téllez, David Sánchez Lorente, Mariano Provencio
INTRODUCTION: Recent advances in the treatment of locally advanced NSCLC have led to changes in the standard of care for this disease. For the selection of the best approach strategy for each patient, it is necessary the homogenization of diagnostic and therapeutic interventions, as well as the promotion of the evaluation of patients by a multidisciplinary oncology team. OBJECTIVE: Development of an expert consensus document with suggestions for the approach and treatment of locally advanced NSCLC leaded by Spanish Lung Cancer Group GECP...
March 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38528720/tracheomediastinal-fistula-induced-by-concurrent-chemoradiotherapy-in-small-cell-lung-cancer-a-case-report-and-literature-review
#2
Yoshihiro Yamamoto, Daisuke Shibahara, Taro Mori, Kohei Otsubo, Yoshimasa Shiraishi, Yasuto Yoneshima, Eiji Iwama, Kentaro Tanaka, Yoshinao Oda, Isamu Okamoto
Tracheomediastinal fistula is a rare but life-threatening complication of cancer. We report a case of tracheomediastinal fistula induced by concurrent chemoradiotherapy in limited stage small cell lung cancer. Despite the treatment response, the metastatic paratracheal lymph node increased gradually during concurrent chemoradiotherapy, resulting in the occurrence of tracheomediastinal fistula and mediastinitis. Without any surgical intervention, the patient achieved successful recovery from mediastinitis through antibiotic treatment, although the tracheomediastinal fistula remained open...
March 25, 2024: Thoracic Cancer
https://read.qxmd.com/read/38528648/a-component-of-high-grade-fetal-lung-adenocarcinoma-diagnosed-as-the-cause-of-lymph-node-metastasis
#3
Daichi Ishii, Satoshi Aoyama, Wataru Arai, Masaru Hasegawa, Akihiko Tanaka, Motoki Sakuraba
High-grade fetal lung adenocarcinoma (H-FLAC) is a rare type of tumor. There have been no reports demonstrating the degree of metastatic susceptibility of this tumor type. In this report, we describe a case in which 15% of the adenocarcinoma components were H-FLAC diagnosed as the cause of lymph node metastasis. A 75-year-old man presented with suspected primary lung cancer (clinical stage IIA, T2bN0M0) and underwent left upper lobectomy and superior mediastinal lymph node dissection. Postoperative histopathology revealed lung cancer with only lobar bronchial lymph node (#11) metastasis...
March 25, 2024: Thoracic Cancer
https://read.qxmd.com/read/38527847/-progress-in-treatment-of-primary-mediastinal-large-b-cell-lymphoma
#4
JOURNAL ARTICLE
L W Chen, J Y Li, L Fan
Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma originating from the thymus, which has different clinical and biological characteristics from diffuse large B-cell lymphoma, NOS. PMBCL tends to occur in young women, usually presenting as a large anterior mediastinal mass. Most patients are in stage Ⅰ-Ⅱ at the time of presentation. There is no standard prognostic scoring system for PMBCL. Immunochemotherapy is commonly used in the treatment of PMBCL, but the optimal first-line treatment has not been determined, and the status of radiotherapy is controversial...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38520577/prognostic-significance-of-the-highest-mediastinal-lymph-node-involvement-in-patients-with-stage-iii-n2-non-small-cell-lung-cancer
#5
JOURNAL ARTICLE
Junhong Liu, Zhihua Shi, Bingji Cao, Zhe Wang, Nan Zhang, Junfeng Liu
BACKGROUND: Highest mediastinal lymph node (HMLN) involvement is a category of uncertain resection, yet the prognostic significance of HMLN involvement remains controversial. METHODS: A total of 486 patients with pathological stage III-N2 disease who underwent radical resection were enrolled from January 2015 to December 2018. Patients were allocated into two groups-HMLN involvement (219 cases) and HMLN-negative (249 cases) groups. Kaplan-Meier analysis and Cox proportional hazard regression models were used to evaluate the impact of HMLN involvement on 5-year recurrence-free survival (RFS) and overall survival (OS)...
March 23, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38505073/surgical-decision-making-in-the-setting-of-unsuspected-n2-disease-a-cost-effectiveness-analysis
#6
JOURNAL ARTICLE
Brian Mitzman, Thomas K Varghese, Wallace L Akerley, Richard E Nelson
BACKGROUND: Identification of unsuspected nodal metastasis may occur at the time of operation for a stage I non-small cell lung cancer. Guidelines for this scenario are unclear. Our goal was to assess the cost-effectiveness of aborting the operation in an attempt to first provide neoadjuvant systemic therapy compared with upfront resection. METHODS: A computer simulation Markov model with a lifetime horizon was constructed to compare the costs and clinical outcomes, as measured by quality-adjusted life-years (QALYs), of upfront resection at the time of identification of unsuspected N2 mediastinal disease vs...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38496704/single-port-video-assisted-thoracoscopic-sleeve-lobectomy-after-neoadjuvant-immunochemotherapy-a-case-report
#7
Hao Chen, Jiarong Zhang, Antonio Rossi, Duilio Divisi, Chun Chen, Bin Zheng
BACKGROUND: The morbidity and mortality of lung cancer have always ranked first among malignant tumors (MTs). Previous studies have shown that neoadjuvant chemotherapy can improve the 5-year survival rate of patients with non-small cell lung cancer (NSCLC), but the benefit is limited. Studies have proven that neoadjuvant immunotherapy combined with chemotherapy has unique advantages in prolonging patient survival, reducing distant recurrence, and inducing antitumor immunity. However, its impact remains to be more comprehensively investigated...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38490228/systematic-endoscopic-staging-of-mediastinum-to-guide-radiotherapy-planning-in-patients-with-locally-advanced-non-small-cell-lung-cancer-seismic-an-international-multicentre-single-arm-clinical-trial
#8
JOURNAL ARTICLE
Daniel P Steinfort, Gargi Kothari, Neil Wallace, Nicholas Hardcastle, Kanishka Rangamuwa, Edith M T Dieleman, Percy Lee, Peixuan Li, Julie A Simpson, Shaun Yo, Farzad Bashirdazeh, Phan Nguyen, Barton R Jennings, David Fielding, Laurence Crombag, Louis B Irving, Kazuhiro Yasufuku, Jouke T Annema, David E Ost, Shankar Siva
BACKGROUND: Systematic mediastinal lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) improves accuracy of staging in patients with early-stage non-small-cell lung cancer (NSCLC). However, patients with locally advanced NSCLC commonly undergo only selective lymph node sampling. This study aimed to determine the proportion of patients with locally advanced NSCLC in whom systematic endoscopic mediastinal staging identified PET-occult lymph node metastases, and to describe the consequences of PET-occult disease on radiotherapy planning...
March 11, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38484584/the-association-of-visceral-pleural-invasion-with-skip-n2-metastasis-on-clinical-stage-ia-nsclc
#9
JOURNAL ARTICLE
Fabio Minamoto, Pedro Araújo, Paula D'Ambrosio, Alberto Dela Vega, Leticia Lauricella, Paulo Pêgo-Fernandes, Ricardo Terra
BACKGROUND: Lung lymphatic drainage occurs mainly through a peribronchial path, but it is hypothesized that visceral pleural invasion could alter this path. This study aims to investigate the association between visceral pleural invasion, node upstaging, and N2 skip metastasis and the impact on survival in a population of patients with non-small cell lung cancer of 3 cm or smaller. METHODS: We retrospectively queried our institutional database of lung cancer resection for all patients with clinical stage IA NSCLC between June 2009 and June 2022...
March 13, 2024: Clinics
https://read.qxmd.com/read/38476646/duodenal-papillary-metastasis-of-lung-cancer-with-bleeding-controlled-by-endoscopic-treatment-and-systemic-osimertinib-therapy-case-report
#10
Taiyo Hirata, Shinya Kawaguchi, Taisuke Akamatsu, Atsuko Inagawa, Tomoki Hikichi, Kohei Ohkawa, Kazuhisa Asahara, Tatsunori Satoh, Shinya Endo, Makoto Suzuki, Kazuya Ohno
INTRODUCTION: Solid organ malignancies rarely metastasize to the duodenal papilla. We describe a case of primary lung cancer with duodenal papillary metastasis in a patient who presented with melena. To the best of our knowledge, this is only the second report of duodenal papillary metastasis from lung cancer. CASE PRESENTATION: A 65-year-old woman presented with complaints of anorexia, weight loss, and black stool. Imaging studies led to a clinical diagnosis of stage IVB lung cancer, and anticoagulants were initiated to treat pulmonary artery thrombosis...
2024: Case Reports in Gastroenterology
https://read.qxmd.com/read/38476366/remarkable-response-to-third-generation-egfr-tki-plus-crizotinib-in-a-patient-with-pulmonary-adenocarcinoma-harboring-egfr-and-ros1-co-mutation-a-case-report
#11
Zhiming Wu, Zelin Zhang, Dongdong Zhang, Zengyan Li
BACKGROUND: Driver oncogene mutations, such as c-ros oncogene 1 (ROS1) and epidermal growth factor receptor (EGFR) were previously believed to be mutually exclusive in non-small cell lung cancer (NSCLC). Only sporadic cases of ROS1 and EGFR co-mutations have been reported. Hence, appropriate treatment options for these patients are still controversial. CASE PRESENTATION: A 48-year-old female patient presented at our hospital complaining of a persistent cough that had been ongoing for a month...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38473295/long-term-outcomes-of-ablative-carbon-ion-radiotherapy-for-central-non-small-cell-lung-cancer-a-single-center-retrospective-study
#12
JOURNAL ARTICLE
Shuri Aoki, Hitoshi Ishikawa, Mio Nakajima, Naoyoshi Yamamoto, Shinichiro Mori, Masaru Wakatsuki, Noriyuki Okonogi, Kazutoshi Murata, Yuji Tada, Teruaki Mizobuchi, Ichiro Yoshino, Shigeru Yamada
The aim of this study is to assess the efficacy and safety of ablative carbon ion radiotherapy (CIRT) for early stage central non-small cell lung cancer (NSCLC). We retrospectively reviewed 30 patients who had received CIRT at 68.4 Gy in 12 fractions for central NSCLC in 2006-2019. The median age was 75 years, and the median Karnofsky Performance Scale score was 90%. All patients had concomitant chronic obstructive pulmonary disease, and 20 patients (67%) were considered inoperable. In DVH analysis, the median lung V5 and V20 were 15...
February 25, 2024: Cancers
https://read.qxmd.com/read/38472125/early-clinical-outcomes-of-thoracoscopic-major-pulmonary-resection-and-thymectomy-using-novel-articulating-endoscopic-forceps
#13
JOURNAL ARTICLE
Sangil Yun, You Jung Ok, Se Jin Oh, Jae-Sung Choi, Hyeon Jong Moon, Yong Won Seong
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is recognized as a safe and effective treatment modality for early-stage lung cancer and anterior mediastinal masses. Recently, novel articulating instruments have been developed and introduced to endoscopic surgery. Here, we share our early experiences with VATS major pulmonary resection and thymectomy performed using ArtiSential articulating instruments. METHODS: At the Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 500 patients underwent VATS pulmonary resection between July 2020 and April 2023, while 43 patients underwent VATS thymectomy between January 2020 and April 2023...
March 13, 2024: Journal of chest surgery
https://read.qxmd.com/read/38471496/shape-sensing-robotic-assisted-bronchoscopy-versus-computed-tomography-guided-transthoracic-biopsy-for-the-evaluation-of-subsolid-pulmonary-nodules
#14
JOURNAL ARTICLE
Sebastian Fernandez-Bussy, Alejandra Yu Lee-Mateus, Janani Reisenauer, Prasanth Balasubramanian, Alanna Barrios-Ruiz, Ana Garza-Salas, Nikitha C Chandra, Anoop Koratala, Anthony Nadrous, Eric S Edell, Andrew W Bowman, Rolf A Grage, Chris J Reisenauer, Anil N Kurup, Neal M Patel, Ryan Chadha, Britney N Hazelett, David Abia-Trujillo
INTRODUCTION: Lung cancer remains the leading cause of cancer death worldwide. Subsolid nodules (SSN), including ground glass nodules (GGN) and part solid nodules (PSN), are slow growing but have a higher risk for malignancy. Therefore, timely diagnosis is imperative. Shape-sensing robotic-assisted bronchoscopy (ssRAB) has emerged as reliable diagnostic procedure, but data on SSN and how ssRAB compares to other diagnostic interventions such as CT-guided transthoracic biopsy (CTTB) is scarce...
March 12, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38470453/the-changing-landscape-of-small-cell-lung-cancer
#15
JOURNAL ARTICLE
Giordano Fabricio Cittolin-Santos, Brendan Knapp, Bharath Ganesh, Feng Gao, Saiama Waqar, Thomas Eldridge Stinchcombe, Ramaswamy Govindan, Daniel Morgensztern
BACKGROUND: Small-cell lung cancer (SCLC) is characterized by rapid proliferation and early dissemination. The objective of this study was to examine the demographic trends and outcomes in SCLC. METHODS: The authors queried the National Cancer Institute's Surveillance, Epidemiology, and End Results database to assess the trends in incidence, demographics, staging, and survival for SCLC from 1975 to 2019. Trends were determined using joinpoint analysis according to the year of diagnosis...
March 12, 2024: Cancer
https://read.qxmd.com/read/38466540/endobronchial-ultrasound-transbronchial-needle-aspiration-effectiveness-and-accuracy-in-non-small-cell-lung-cancer-staging
#16
JOURNAL ARTICLE
Maria Giovanna Mastromarino, Elena Guerrini, Giacomo Rabazzi, Diana Bacchin, Alessandro Picchi, Olivia Fanucchi, Vittorio Aprile, Stylianos Korasidis, Greta Alì, Alessandro Ribechini, Marco Lucchi, Marcello Carlo Ambrogi
INTRODUCTION: Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) has a cardinal role in the diagnosis and staging of non-small cell lung cancer (NSCLC), providing an accurate nodal staging in a less invasive way than surgical biopsy. The aim of this study was to assess the diagnostic accuracy of EBUS-TBNA in the pre-operative NSCLC mediastinal staging, as well as to evaluate EBUS-TBNA specificity and sensibility in our cohort. METHODS: We retrospectively analyzed data of NSCLC patients who underwent EBUS-TBNA followed by major pulmonary resection between January 2020 and December 2022...
March 11, 2024: Updates in Surgery
https://read.qxmd.com/read/38466235/lymph-node-metastases-in-middle-and-upper-mediastinum-of-siewert-type-ii-adenocarcinoma-a-real-world-retrospective-study
#17
JOURNAL ARTICLE
Peng Luo, Xiankai Chen, Yafan Yang, Ruixiang Zhang, Xiaozheng Kang, Jianjun Qin, Xiuzhu Qi, Yin Li
OBJECTIVE: To explore whether the upper and/or middle mediastinal nodes (UMMN) should be dissected in Siewert type II adenocarcinoma (AC) according to the incidence of lymph node metastasis. Additionally, to investigate the association between the length of esophageal involvement (LEI) and the UMMN metastases. METHODS: A cohort with Siewert type II AC who were operated on by a surgical team that routinely treated esophagogastric junction (EGJ) tumors with esophagectomy and extended lymphadenectomy were assessed retrospectively...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38458808/survival-outcomes-following-complete-mediastinal-lymphadenectomy-or-selective-mediastinal-lymphadenectomy-in-patients-with-stage-i-iiia-non-small-cell-lung-cancer-protocol-for-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Jianfeng Xu, Jinxing Lai, Xiongfeng Huang, Yuxi Ren, Qiao Chen, Weijuan Li
INTRODUCTION: Lung cancer remains the largest cause of cancer-related deaths worldwide. Surgical removal of non-small cell lung cancer (NSCLC) has the potential to achieve a cure, although there is ongoing debate regarding the significance of removing mediastinal nodes and the optimal extent of lymph node excision. The purpose of this research is to assess the survival outcomes in patients diagnosed with stage I-IIIA NSCLC who received either complete mediastinal lymphadenectomy (CML) or selective mediastinal lymphadenectomy (SML)...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38454623/texture-analysis-of-18f-fdg-pet-ct-and-cect-prediction-of-refractoriness-of-hodgkin-lymphoma-with-mediastinal-bulk-involvement
#19
JOURNAL ARTICLE
Elisabetta M Abenavoli, Flavia Linguanti, Matilde Anichini, Vittorio Miele, Francesco Mungai, Marianna Palazzo, Luca Nassi, Benedetta Puccini, Ilaria Romano, Benedetta Sordi, Roberto Sciagrà, Gabriele Simontacchi, Alessandro M Vannucchi, Valentina Berti
To recognize patients at high risk of refractory disease, the identification of novel prognostic parameters improving stratification of newly diagnosed Hodgkin Lymphoma (HL) is still needed. This study investigates the potential value of metabolic and texture features, extracted from baseline 18F-FDG Positron Emission Tomography/Computed Tomography (PET) and Contrast-Enhanced Computed Tomography scan (CECT), together with clinical data, in predicting first-line therapy refractoriness (R) of classical HL (cHL) with mediastinal bulk involvement...
March 2024: Hematological Oncology
https://read.qxmd.com/read/38452642/a-primary-pleural-hydatid-cyst-was-discovered-months-after-an-undiagnosed-pneumothorax-a-diagnostic-and-therapeutic-dilemma-in-a-rare-case-report-from-syria
#20
Hamdah Hanifa, Turki Al-Shaher, Mamoun Jaber, Jaafar Alatm, Khayry Al-Shami, Salem Algomaa Alhadid
INTRODUCTION: Primary pleural hydatid cysts (PPHCs) are a rare clinical condition caused by the larval stage of the parasite Echinococcus granulosus. They occur in <1 % of all hydatid cysts in the body and can cause serious complications such as pneumothorax, pleural effusion, and mediastinal shift. PRESENTATION OF CASE: We report a rare case of a 28-year-old female who was initially misdiagnosed and ignored her pneumothorax for several months, resulting in progressive dyspnea and chest pain...
March 5, 2024: International Journal of Surgery Case Reports
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