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https://www.readbyqxmd.com/read/29913528/blood-pressure-and-cognitive-performance-after-a-single-administration-of-a-camphor-crataegus-combination-in-adolescents-with-low-blood-pressure
#1
Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913521/comparison-of-efficacy-embolism-rate-and-safety-of-thrombectomy-with-stent-retrievers-in-an-anterior-circulation-stroke-model
#2
Naomi Larsen, Katharina Oberbeck, Rodrigo Lima de Miranda, Jens Trentmann, Jawid Madjidyar, Eckhard Quandt, Olav Jansen
PURPOSE:  Various stent retrievers differing in stent design and mechanical properties are currently available for the treatment of ischemic stroke. We conducted this in vitro study to compare the efficacy, embolism rate, and safety of commercially available stent retrievers and prototypes. MATERIALS AND METHODS:  Whole blood thrombi were produced in a Chandler loop. The thrombi were inserted into the curved M1 segment of a silicone model of the anterior cerebral circulation...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913486/prognostic-implications-of-single-sample-confirmatory-testing-for-undiagnosed-diabetes-a-prospective-cohort-study
#3
Elizabeth Selvin, Dan Wang, Kunihiro Matsushita, Morgan E Grams, Josef Coresh
Background: Current clinical definitions of diabetes require repeated blood work to confirm elevated levels of glucose or hemoglobin A1c (HbA1c) to reduce the possibility of a false-positive diagnosis. Whether 2 different tests from a single blood sample provide adequate confirmation is uncertain. Objective: To examine the prognostic performance of a single-sample confirmatory definition of undiagnosed diabetes. Design: Prospective cohort study...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913481/deficiency-of-long-chain-polyunsaturated-fatty-acids-in-phenylketonuria-a-cross-sectional-study
#4
Sławomira Drzymała-Czyż, Łukasz Kałużny, Patrycja Krzyżanowska-Jankowska, Dariusz Walkowiak, Renata Mozrzymas, Jarosław Walkowiak
The etiology of altered blood fatty acid (FA) profile in phenylketonuria (PKU) is understood only partially. We aimed to determine whether FAs deficiency is dependent on the diet or metabolic disturbances. The study comprised 40 PKU patients (20 female, 20 male; aged 11 to 35 years; 12 children and 28 adults) and 40 healthy subjects (HS; 20 female, 20 male, aged 18 to 33 years). We assessed the profile of FAs (gas chromatography/mass spectrometry) and analyzed the 72-hour dietary recalls. The amount of C14:0, C16:0 and C16:1n-7, C18:1n-9 did not differ between the analyzed groups...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913457/anti-inflammatory-action-of-sitagliptin-and-linagliptin-in-doxorubicin-nephropathy
#5
Chor Ho Jo, Sua Kim, Joon-Sung Park, Gheun-Ho Kim
BACKGROUND/AIMS: Dipeptidyl peptidase-4 (DPP4) inhibitors are known to have a protective effect on diabetic kidney disease, possibly via reduction of oxidative stress and inflammation in the kidney. However, whether these potential mechanisms play a role in non-diabetic proteinuric kidney diseases is not clear. METHODS: Two different animal experiments were carried out using sitagliptin and linagliptin for DPP4 inhibition. In each experiment, male Sprague-Dawley rats were uninephrectomized and randomly divided into vehicle-treated and doxorubicin-treated rats, with or without DPP4 inhibition...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913442/associations-of-pulmonary-fibrosis-with-peripheral-blood-th1-th2-cell-imbalance-and-ebf3-gene-methylation-in-uygur-pigeon-breeder-s-lung-patients
#6
Chao Wu, Zujin Luo, Baosen Pang, Wenyi Wang, Mingqin Deng, Rong Jin, Xirennayi Muhataer, Yafang Li, Qifeng Li, Xiaohong Yang
Background/Aims Pigeon breeder's lung (PBL) results from Th1/Th2 cell imbalance. B cells inhibit the immune activity of Th1, and EBF3 is a key B cell factor. This study explored the relationship between EBF3 and Th1/Th2 imbalance in chronic PBL cases complicated with pulmonary fibrosis (PF). Methods Twenty Uygur PBL+PF patients, 20 pigeon breeders without PBL or PF, and 20 healthy individuals without pigeon breeding history constituted the patient I, negative control, and normal control groups, respectively...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913389/biomimetic-o-2-evolving-metal-organic-framework-nanoplatform-for-highly-efficient-photodynamic-therapy-against-hypoxic-tumor
#7
Shutao Gao, Pengli Zheng, Zhenhua Li, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang, Jinchao Zhang
Improving the supply of O2 and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O2 -evolving photodynamic therapy (PDT) nanoplatform with long circulating properties was fabricated. Zirconium (IV)-based MOF (UiO-66) was used as a vehicle for O2 storing, then conjugated with indocyanine green (ICG) by coordination reaction, and further coated with red blood cell (RBC) membranes...
June 7, 2018: Biomaterials
https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#8
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913322/culture-supernatants-of-oral-cancer-cells-induce-impaired-ifn-%C3%AE-production-of-pdcs-partly-through-the-down-regulation-of-tlr-9-expression
#9
Nannan Han, Zun Zhang, Houyu Jv, Jingzhou Hu, Min Ruan, Chenping Zhang
OBJECTIVES: The aim of the present study was to investigate whether tumor-derived supernatants down-regulate the immune function of plasmacytoid dendritic cells (pDCs) in oral cancer and the potential molecular mechanisms of this effect. MATERIALS AND METHODS: Immunohistochemistry (IHC) and flow cytometry were used to detect tumor-infiltrating and peripheral blood pDCs. MTS and flow cytometry were employed to evaluate the immune response of CD4+ T cells. Real-time PCR and ELISA assays were used to identify TLR-7 and TLR-9 expression, IFN-α production and tumor-secreted soluble cytokines...
June 5, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29913309/the-causes-and-consequences-of-variation-in-human-cytokine-production-in-health
#10
REVIEW
Melanie Schirmer, Vinod Kumar, Mihai G Netea, Ramnik J Xavier
Cytokines are important cell-signaling molecules that activate and modulate immune responses. Major factors influencing cytokine variation in healthy individuals are host genetics, non-heritable factors and the microbiome. Genetic variation accounts for a significant part of heterogeneity in cytokine production by peripheral blood mononuclear cells. Variation in cytokines such as IL-6 and IL-6Ra is strongly influenced by heritability, suggesting an evolutionarily pressure for their genetic regulation that potentially contributes to differences in immune responsiveness between human populations...
June 15, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29913299/pharmacological-and-toxicological-study-of-a-chemical-standardized-ethanol-extract-of-the-branches-and-leaves-from-eysenhardtia-polystachya-ortega-sarg-fabaceae
#11
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913298/antihypertensive-effect-of-the-methanolic-extract-from-eruca-sativa-mill-brassicaceae-in-rats-muscarinic-receptor-linked-vasorelaxant-and-cardiotonic-effects
#12
Umme Salma, Taous Khan, Abdul Jabbar Shah
ETHNOPHARMACOLOGICAL RELEVANCE: Eruca sativa Mill., (Brassicaceae) is a popular remedy for the treatment of hypertension in Pakistan. However, direct effect of the extract and its fractions on blood pressure and vascular tone are unknown. AIM OF THE STUDY: This investigation was aimed to explore the pharmacological base for the traditional use of E. sativa in hypertension. MATERIALS AND METHODS: In-vivo blood pressure study was carried out using normotensive and high salt-induced hypertensive rats under anaesthesia...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913284/effect-sizes-of-bold-cvr-resting-state-signal-fluctuations-and-time-delay-measures-for-the-assessment-of-hemodynamic-impairment-in-carotid-occlusion-patients
#13
Jill B De Vis, Alex A Bhogal, Jeroen Hendrikse, Esben T Petersen, Jeroen C W Siero
BACKGROUND AND PURPOSE: The BOLD signal amplitude as a response to a hypercapnia stimulus is commonly used to assess cerebrovascular reserve. Despite recent advances, the implementation remains cumbersome and alternative ways to assess hemodynamic impairment are desirable. Resting-state BOLD signal fluctuations (rsBOLD) have been proposed however data on its sensitivity and dependence on baseline venous cerebral blood volume (vCBV) is limited. The primary aim of this study was to compare the effect sizes of resting-state and hypercapnia induced BOLD signal changes in the detection of hemodynamic impairment...
June 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29913220/nootropic-nanocomplex-with-enhanced-blood-brain-barrier-permeability-for-treatment-of-traumatic-brain-injury-associated-neurodegeneration
#14
REVIEW
Jeongmin Park, Eunshil Choi, Seulgi Shin, Sungsu Lim, Dohee Kim, Suji Baek, Kang Pa Lee, Jae Jun Lee, Byeong Han Lee, Bokyung Kim, Keunsoo Jeong, Ja-Hyun Baik, Yun Kyung Kim, Sehoon Kim
Traumatic brain injury (TBI) is an intracranial injury which can induce immediate neuroinflammation and long-term neurological deficits. Methylene blue (MB) as a nootropic has a great potential to treat neurodegeneration after TBI because of its anti-inflmmatory and neuroprotective functions. However, its limited accumulation to the brain across the blood-brain barrier (BBB) remains a major hurdle to be overcome. In this paper, we present a polymer surfactant-encapsulated nanocomplex of MB as a delivery system with high BBB permeability for efficacious treatment of TBI-induced neurodegeneration...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913204/phenotypic-identification-of-periodontal-prevotella-intermedia-nigrescens-group-isolates-validated-by-maldi-tof-mass-spectrometry
#15
Thomas E Rams, Jacqueline D Sautter, Chinhua Y Hsiao, Arie J van Winkelhoff
The accuracy of a phenotypic scheme to recognize periodontal Prevotella intermedia/nigrescens group clinical isolates on primary isolation culture plates was assessed with matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). A total of 84 fresh subgingival isolates from 23 chronic periodontitis patients were presumptively recognized on anaerobically-incubated enriched Brucella blood agar primary isolation plates as P. intermedia/nigrescens based on their dark-pigmented colony morphology, brick-red autofluorescence under long-wave ultraviolet light, and a negative fluorescence test for lactose production...
June 15, 2018: Anaerobe
https://www.readbyqxmd.com/read/29913196/pntx2-6-or-%C3%AE-cntx-pn2a-a-toxin-from-phoneutria-nigriventer-spider-venom-releases-l-glutamate-from-rat-brain-synaptosomes-involving-na-and-ca-2-channels-and-changes-protein-expression-at-the-blood-brain-barrier
#16
Carolina Nunes da Silva, Rosângela Silva Lomeo, Fernanda Silva Torres, Marcia Helena Borges, Marta Cordeiro Nascimento, Maria Helena Rodrigues Mesquita-Britto, Catarina Rapôso, Adriano Monteiro de Castro Pimenta, Maria Alice da Cruz-Höfling, Dawidson Assis Gomes, Maria Elena de Lima
PhTx2 is the most toxic fraction from the venom of the spider Phoneutria nigriventer, being responsible to sodium entry into cortical synaptosomes, increasing the release of neurotransmitters, such as l-glutamate (L-Glu) and; acetylcholine. In this study, we investigated the action of a toxin purified from; PhTx2 fraction, called PnTx2-6 or δ-CNTX-Pn2a, on L-Glu release from rat; brain cortex synaptosomes, as well as its ability to induce blood-brain barrier permeability. PnTx2-6 increased L-Glu release from rat cortical brain synaptosomes in a time- and dose-dependent manner (EC50 = ∼20 nM; Tm = 16min), as measured by a fluorimetric method...
June 15, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29913184/superparamagnetic-iron-oxide-nanocolloids-in-mri-studies-of-neuroinflammation
#17
Lorenzo Ugga, Valeria Romeo, Enrico Tedeschi, Arturo Brunetti, Mario Quarantelli
Iron oxide (IO) nanocolloids are being increasingly used to image cellular contribution to neuroinflammation using MRI, as these particles are capable of labeling circulating cells with phagocytic activity, allowing to assess cell trafficking from the blood to neuroinflammation sites. The use of IOs relies on the natural phagocytic properties of immune cells, allowing their labeling either in vitro or directly in vivo, following intravenous injection. Despite concerns on the specificity of the latter approach, the widespread availability and relatively low cost of these techniques, coupled to a sensitivity that allows to reach single cell detection, have promoted their use in several preclinical and clinical studies...
June 15, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29913142/plasma-exosomes-regulate-systemic-blood-pressure-in-rats
#18
Kosuke Otani, Mai Yokoya, Tomoko Kodama, Kiko Hori, Kengo Matsumoto, Muneyoshi Okada, Hideyuki Yamawaki
Exosomes, the smallest extracellular vesicle, contain various molecules and mediate cell-cell communication. A number of studies demonstrate exosomes are involved in important physiological and pathological processes. Moreover, microRNA (miRNA) regulating hypertension development through the suppression of certain translation was recently reported. However, roles of exosomes containing various molecules including miRNA on development of essential hypertension have not been examined. We tested the hypothesis that plasma exosomes regulate systemic blood pressure in normotensive and spontaneously hypertensive rats (SHR)...
June 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29913111/glial-derived-neurotrophic-factor-is-essential-for-blood-nerve-barrier-functional-recovery-in-an-experimental-murine-model-of-traumatic-peripheral-neuropathy
#19
Chaoling Dong, E Scott Helton, Ping Zhou, Xuan Ouyang, Xavier d'Anglemont de Tassigny, Alberto Pascual, José López-Barneo, Eroboghene E Ubogu
There is emerging evidence that glial-derived neurotrophic factor (GDNF) is a potent inducer of restrictive barrier function in tight junction-forming microvascular endothelium and epithelium, including the human blood-nerve barrier (BNB) in vitro. We sought to determine the role of GDNF in restoring BNB function in vivo by evaluating sciatic nerve horseradish peroxidase (HRP) permeability in tamoxifen-inducible GDNF conditional knockout (CKO) adult mice following non-transecting crush injury via electron microscopy, with appropriate wildtype (WT) and heterozygous (HET) littermate controls...
June 18, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29913077/higher-exosomal-tau-amyloid-beta-42-and-il-10-are-associated-with-mild-tbis-and-chronic-symptoms-in-military-personnel
#20
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
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