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non-invasive screening tests for vascular diseases

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https://www.readbyqxmd.com/read/27817745/cell-free-circulating-epigenomic-signatures-non-invasive-biomarker-for-cardiovascular-and-other-age-related-chronic-diseases
#1
Arpit Bhargava, Naveen Kumar Khare, Neha Bunkar, Koel Chaudhury, Kailash Chand Pandey, Subodh Kumar Jain, Pradyumna Kumar Mishra
The burden of cardio-vascular and other age-related non-communicable diseases are rapidly increasing worldwide. Majority of these chronic ailments are curable, if diagnosed at early stages. Candidate biomarkers of early detection are therefore essential for identification of high-risk individuals, prompt and accurate disease diagnosis, and to monitor therapeutic response. The functional significance of circulating nucleic acids that recapitulate specific disease profiles is now well established. But subtle changes in DNA sequence may not solely reflect the differentiation of gene expression patterns observed in diverse set of diseases as epigenetic phenomena play a larger role in aetiology and patho-physiology...
October 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27165712/a-systematic-review-of-the-sensitivity-and-specificity-of-the-toe-brachial-index-for-detecting-peripheral-artery-disease
#2
REVIEW
Peta Ellen Tehan, Derek Santos, Vivienne Helaine Chuter
The toe-brachial index (TBI) is used as an adjunct to the ankle-brachial index (ABI) for non-invasive lower limb vascular screening. With increasing evidence suggesting limitations of the ABI for diagnosis of vascular complications, particularly in specific populations including diabetes cohorts, the TBI is being used more widely. The aim of this review was to determine the sensitivity and specificity of the TBI for detecting peripheral artery disease (PAD) in populations at risk of this disease. A database search was conducted to identify current work relating to the sensitivity and specificity of toe-brachial indices up to July 2015...
August 2016: Vascular Medicine
https://www.readbyqxmd.com/read/26315799/magnetic-resonance-imaging-in-proximal-venous-outflow-obstruction
#3
Benjamin B Massenburg, Harvey N Himel, Robert C Blue, Michael L Marin, Peter L Faries, Windsor Ting
BACKGROUND: Proximal venous outflow obstruction (PVOO) in the abdomen and pelvis is increasingly recognized as an important contributor to venous disease of the lower extremity. There are currently no guidelines regarding a noninvasive screening tool for PVOO, although magnetic resonance venography (MRV) is commonly used in many practices. The objective of this study was to determine the value and utility of MRV in diagnosis and screening for PVOO. METHODS: This retrospective study consisted of 46 consecutive patients, all of whom presented with signs and/or symptoms of PVOO and were evaluated with MRV followed by intravascular ultrasound (IVUS) and venography...
November 2015: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/26281971/non-invasive-vascular-assessment-in-the-foot-with-diabetes-sensitivity-and-specificity-of-the-ankle-brachial-index-toe-brachial-index-and-continuous-wave-doppler-for-detecting-peripheral-arterial-disease
#4
Peta Ellen Tehan, Alan Bray, Vivienne Helaine Chuter
BACKGROUND & AIMS: Non-invasive lower limb vascular assessment in people at risk of peripheral arterial disease (PAD) including those with diabetes is crucial. There is evidence that standard assessment techniques such as the ankle-brachial index (ABI) may be less effective in people with diabetes. However there is limited evidence for other frequently used tests including continuous wave Doppler (CWD), and the toe-brachial index (TBI). The aim of this study was to determine the sensitivity and specificity of, ABI, CWD and TBI in a population with, and without diabetes...
January 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26166793/pulmonary-hypertension-in-the-course-of-diffuse-parenchymal-lung-diseases-state-of-art-and-future-considerations
#5
Monika Szturmowicz, Aneta Kacprzak, Katarzyna Błasińska-Przerwa, Jan Kuś
Lung diseases are one of the most frequent causes of pulmonary hypertension (PH). The development of PH influences the course of lung disease, worsening the clinical symptoms and prognosis. According to the most recent publications, PH in the course of lung diseases develops as a result of both "parenchymal" and vascular pathology, in the patients with genetic predisposition. Prolonged infection (especially viral one) may be an additional promoting factor. Right heart catheterization (RHC), which is an invasive procedure, is the only objective method of diagnosing PH...
2015: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/25298200/utility-of-transcranial-ultrasound-in-predicting-alzheimer-s-disease-risk
#6
REVIEW
Aleš Tomek, Barbora Urbanová, Jakub Hort
Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by an increasing incidence. One of the pathologic processes that underlie this disorder is impairment of brain microvasculature. Transcranial ultrasound is a non-invasive examination of cerebral blood flow that can be employed as a simple and useful screening tool for assessing the vascular status of brain circulation in preclinical and clinical stages of AD. The objective of this review is to explore the utility of using a transcranial ultrasound to diagnose AD...
2014: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/24853913/evaluation-of-the-algorithm-for-automatic-identification-of-the-common-carotid-artery-in-artsens
#7
Ashish Kumar Sahani, Jayaraj Joseph, Mohanasankar Sivaprakasam
Arterial compliance (AC) is an indicator of the risk of cardiovascular diseases (CVDs) and it is generally estimated by B-mode ultrasound investigation. The number of sonologists in low- and middle-income countries is very disproportionate to the extent of CVD. To bridge this gap we are developing an image-free CVD risk screening tool-arterial stiffness evaluation for non-invasive screening (ARTSENS™) which can be operated with minimal training. ARTSENS uses a single element ultrasound transducer to investigate the wall dynamics of the common carotid artery (CCA) and subsequently measure the AC...
July 2014: Physiological Measurement
https://www.readbyqxmd.com/read/24722795/exhaled-breath-temperature-in-nsclc-could-be-a-new-non-invasive-marker
#8
Giovanna E Carpagnano, Donato Lacedonia, Antonio Spanevello, Domenico Martinelli, Valerio Saliani, Cinzia Ruggieri, Maria P Foschino-Barbaro
The exhaled breath temperature (EBT) has been proven to be the expression of airways inflammation as well as of the increased vascularity. Although both these conditions characterize lung cancer pathogenesis, this is the first study where the EBT has been analysed in patients affected by non-small-cell lung cancer. The aim of this study was to verify whether and how the lung cancer being examined influences the EBT for possible future clinical implications. Eighty-two consecutive subjects with a radiological suspicion of lung cancer were enrolled and underwent standard diagnostic and staging procedures for cancer...
May 2014: Medical Oncology
https://www.readbyqxmd.com/read/24655692/improving-diagnosis-and-treatment-of-women-with-angina-pectoris-and-microvascular-disease-the-ipower-study-design-and-rationale
#9
REVIEW
Eva Prescott, Steen Zabell Abildstrøm, Ahmed Aziz, Noel Bairey Merz, Ida Gustafsson, Julian Halcox, Henrik Steen Hansen, Peter Riis Hansen, Jens Kastrup, Marie Michelsen, Naja Dam Mygind, Peter Ong, Adam Pena, Annika Rosengren, Udo Sechtem, Peter Søgaard
BACKGROUND: The iPOWER study aims at determining whether routine assessment of coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease is feasible and identifies women at risk. METHODS: All women with angina referred to invasive angiographic assessment in Eastern Denmark are invited to join the study according to in- and exclusion criteria. Assessment includes demographic, clinical and psychosocial data, symptoms, electrocardiogram, blood- and urine samples and transthoracic echocardiography during rest and dipyridamol stress with measurement of coronary flow reserve (CFR) by Doppler of the left anterior descending artery...
April 2014: American Heart Journal
https://www.readbyqxmd.com/read/24603944/ultrasound-subclinical-markers-in-assessing-vascular-changes-in-cognitive-decline-and-dementia
#10
REVIEW
Vida Demarin, Sandra Morovic
Aging is often associated with some cognitive impairment. Greater population life expectancy is one explanation for increased incidence of cognitive impairment cases. Large numbers of people with cognitive impairment and dementia is becoming one of the most important medical and social problems worldwide. Therefore, prevention of cognitive impairment is an imperative. Dementia includes a heterogeneous group of disorders, the most common being Alzheimer's disease and vascular dementia. Most cardiovascular risk factors, such as hypertension, diabetes mellitus, hypercholesterolemia, atrial fibrillation, and smoking, are not exclusively risk factors for vascular dementia, but also for Alzheimer's disease...
2014: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/24371474/new-echocardiographic-tehniques-in-pulmonary-arterial-hypertension-vs-right-heart-catheterization-a-pilot-study
#11
Tudor Constantinescu, Stefania Lucia Magda, Rodica Niculescu, Raluca Ileana Mincu, Dragos Zaharia, Claudia Lucia Toma, Mircea Cinteza, Miron Alexandru Bogdan
ABSTRACT: HASH(0x46c8198) BACKGROUND: Pulmonary arterial hypertension (PAH) represents an emerging pathology in modern medicine. Transthoracic echocardiography is an inexpensive and reproducible method and it is the most commonly used non-invasive diagnostic tool to asses pulmonary artery pressure (PAP) and the function of the right ventricle. Although, the right heart catheterization is still considered as the standard for the diagnosis, according to the last guidelines, the new echocardiographic methods may offer an improved value in the PAH evaluation...
June 2013: Mædica
https://www.readbyqxmd.com/read/24058335/circulating-cell-free-microrna-as-biomarkers-for-screening-diagnosis-and-monitoring-of-neurodegenerative-diseases-and-other-neurologic-pathologies
#12
REVIEW
Kira S Sheinerman, Samuil R Umansky
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson disease, vascular and frontotemporal dementias, as well as other chronic neurological pathologies, are characterized by slow development with a long asymptomatic period followed by a stage with mild clinical symptoms. As a consequence, these serious pathologies are diagnosed late in the course of a disease, when massive death of neurons has already occurred and effective therapeutic intervention is problematic. Thus, the development of screening tests capable of detecting neurodegenerative diseases during early, preferably asymptomatic, stages is a high unmet need...
2013: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/23796154/plasma-protein-biosignatures-for-detection-of-cardiac-allograft-vasculopathy
#13
David Lin, Gabriela Cohen Freue, Zsuzsanna Hollander, G B John Mancini, Mayu Sasaki, Alice Mui, Janet Wilson-McManus, Andrew Ignaszewski, Carol Imai, Anna Meredith, Robert Balshaw, Raymond T Ng, Paul A Keown, W Robert McMaster, Ron Carere, John G Webb, Bruce M McManus
BACKGROUND: Coronary angiography remains the most widely used tool for routine screening and diagnosis of cardiac allograft vasculopathy (CAV), a major pathologic process that develops in 50% of cardiac transplant recipients beyond the first year after transplant. Given the invasiveness, expense, discomfort, and risk of complications associated with angiography, a minimally invasive alternative that is sensitive and specific would be highly desirable for monitoring CAV in patients. METHODS: Plasma proteomic analysis using isobaric tags for relative and absolute quantitation-matrix-assisted laser desorption ionization double time-of-flight mass spectrometry was carried out on samples from 40 cardiac transplant patients (10 CAV, 9 non-significant CAV, 21 possible CAV)...
July 2013: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/23063897/-skin-autofluorescence-measurement-in-the-clinical-practice-of-diabetology-and-nephrology
#14
REVIEW
Emília Mácsai
Formation of advanced glycation end-products plays role in the pathogenesis of diabetic complications and related ongoing connective tissue degeneration as part of atherosclerosis and chronic kidney disease. The cumulative metabolic burden of patients can be measured in few minutes using a recently developed non-invasive mobile device, which has been developed for the evaluation of fluorescent advanced glycation end-product molecules in skin. The variation of skin autofluorescence measurement is about 10%, and its predictive value in cardiovascular events overcomes conventional glycemic markers even in chronic kidney disease population...
October 21, 2012: Orvosi Hetilap
https://www.readbyqxmd.com/read/21387665/-role-of-global-vascular-intervention-on-long-term-prognosis-in-patients-with-coronary-artery-disease
#15
REVIEW
Hiroyoshi Yokoi
Although recent advance of coronary intervention therapy for coronary artery disease (CAD) is remarkable, long-term clinical outcomes were similar with the past decade. Recent study demonstrated that poly-vascular disease was associated with a significant higher-risk of major adverse cardiovascular events in patients with CAD. The treatment of peripheral artery disease (PAD) reaches to improvement in exercise performance. Revascularization for atherosclerotic renal artery stenosis (ARAS) is associated with reduction in blood pressure and preservation of renal function...
February 2011: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/21343260/upper-extremity-deep-venous-thrombosis
#16
REVIEW
Michael Czihal, Ulrich Hoffmann
Upper extremity deep venous thrombosis is a serious disease entity which, based on the pathogenesis and in view of the individual patient's prognosis, must be divided into a primary and a secondary form. Primary upper extremity deep venous thrombosis is, when related to effort, a rather benign disease with excellent prognosis quoad vitam, carrying only a minor potential of developing disabling post-thrombotic syndrome. If primary upper extremity deep venous thrombosis occurs without any obvious cause, screening for underlying malignancy is recommended...
June 2011: Vascular Medicine
https://www.readbyqxmd.com/read/20156042/a-review-of-simple-non-invasive-means-of-assessing-peripheral-arterial-disease-and-implications-for-medical-management
#17
REVIEW
Alexandre C Ferreira, Francisco Yturi Bulcão Macedo
Abstract Atherosclerotic peripheral arterial disease (PAD) is highly prevalent in the elderly and subjects with atherosclerotic risk factors such as smoking, diabetes mellitus, hypertension, and hyperlipidemia. Importantly, PAD is rarely an isolated condition, but rather a manifestation of systemic atherosclerosis. Hence, there is often coexisting disease in the coronary and cerebral arteries and, consequently, an increased risk of myocardial infarction and stroke. Intermittent claudication is the classic symptom of PAD, yet up to 50% of patients are asymptomatic...
March 2010: Annals of Medicine
https://www.readbyqxmd.com/read/20140524/a-comparison-of-echocardiography-to-invasive-measurement-in-the-evaluation-of-pulmonary-arterial-hypertension-in-a-rat-model
#18
COMPARATIVE STUDY
Juha W Koskenvuo, Rachel Mirsky, Yan Zhang, Franca S Angeli, Sarah Jahn, Tero-Pekka Alastalo, Nelson B Schiller, Andrew J Boyle, Kanu Chatterjee, Teresa De Marco, Yerem Yeghiazarians
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by progressive elevation in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (TPVR). Recent advances in imaging techniques have allowed the development of new echocardiographic parameters to evaluate disease progression. However, there are no reports comparing the diagnostic performance of these non-invasive parameters to each other and to invasive measurements. Therefore, we investigated the diagnostic yield of echocardiographically derived TPVR and Doppler parameters of PAP in screening and measuring the severity of PAH in a rat model...
June 2010: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/20123429/imaging-evaluation-of-lower-extremity-infrainguinal-disease-role-of-the-noninvasive-vascular-laboratory-computed-tomography-angiography-and-magnetic-resonance-angiography
#19
REVIEW
Danny Chan, Matthew E Anderson, Bart L Dolmatch
Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that commonly affects the lower extremities. The diagnosis of PAD and the subsequent treatment decisions rely on clinical exam and non-invasive imaging. The imaging modalities that aid in both diagnosis and treatment are the non-invasive vascular laboratory, computed tomography angiography (CTA) and magnetic resonance angiography (MRA). Each modality has its own advantages and limitations. Non-invasive vascular laboratory testing can be used as a good screening tool for PAD and is often used in conjunction with an additional imaging modality if necessary...
March 2010: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/19963956/how-to-measure-peripheral-pulmonary-vascular-mechanics
#20
Naomi C Chesler, Paola Argiento, Rebecca Vanderpool, Michele D'Alto, Robert Naeije
Pulmonary hypertension (PH) is initially a disease of the small, peripheral resistance arteries. Changes in these vessels are best assessed by measurement of pulmonary artery pressure at several levels of flow to generate multi-point pressure-flow curves. This approach is superior to the traditional single-point measurement of pulmonary vascular resistance (PVR) because it allows a flow-independent definition of the resistive properties of that portion of the pulmonary vascular bed and also provides information on its distensibility...
2009: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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