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pain control in arthritis

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https://www.readbyqxmd.com/read/28334783/amitriptyline-for-musculoskeletal-complaints-a-systematic-review
#1
Jacoline J van den Driest, Sita M A Bierma-Zeinstra, Patrick J E Bindels, Dieuwke Schiphof
Background.: The role of amitriptyline in musculoskeletal pain is not as clearly defined as in classical neuropathic pain conditions. Objective.: To assess the efficacy and effectiveness of amitriptyline in the treatment of pain in musculoskeletal complaints. Methods.: An extensive search (including Medline, Embase and Web of Science) was made up to April 2016 for randomised controlled trials on amitriptyline in musculoskeletal complaints compared to placebo, usual care, or other analgesic use...
January 30, 2017: Family Practice
https://www.readbyqxmd.com/read/28328575/predictors-and-social-consequences-of-daily-pain-expectancy-among-adults-with-chronic-pain
#2
Chung Jung Mun, Kirti Thummala, Mary C Davis, Paul Karoly, Howard Tennen, Alex J Zautra
Previous research suggests that for people living with chronic pain, pain expectancy can undermine access to adaptive resources and functioning. We tested and replicated the unique effect of pain expectancy on subsequent pain through two daily diary studies. We also extended previous findings by examining cognitive and affective antecedents of pain expectancy and the consequences of pain expectancy for daily social enjoyment and stress. In Study 1, 231 individuals with rheumatoid arthritis completed 30-end of day diaries...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28327134/the-effect-of-intra-articular-botulinum-toxin-a-on-substance-p-prostaglandin-e2-and-tumor-necrosis-factor-alpha-in-the-canine-osteoarthritic-joint
#3
Helka M Heikkilä, Anna K Hielm-Björkman, John F Innes, Outi M Laitinen-Vapaavuori
BACKGROUND: Recently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism of the antinociceptive action of IA BoNT A is currently not known. The aim of this study was to explore this mechanism of action by investigating the effect of IA BoNT A on synovial fluid (SF) and serum substance P (SP), prostaglandin E2 (PGE2), and tumor necrosis factor alpha (TNF-α) in osteoarthritic dogs...
March 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28323761/effect-of-land-based-generic-physical-activity-interventions-on-pain-physical-function-and-physical-performance-in-hip-and-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#4
Shanelle Fernandopulle, Meredith Perry, Donald Manlapaz, Prasath Jayakaran
OBJECTIVE: The aim of this study was to evaluate the effects of land-based generic physical activity interventions on pain, physical function, and physical performance in individuals with hip/knee osteoarthritis, when compared with a control group that received no intervention, minimal intervention, or usual care. METHODS: A systematic search for randomized controlled trials on 11 electronic databases (from their inception up until April 30, 2016) identified 27 relevant articles...
March 18, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#5
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28290757/hip-musculoskeletal-conditions-and-associated-factors-that-influence-squat-performance-a-systematic-review
#6
Scott W Cheatham, Kyle R Stull, Mike Fantigrassi, Ian Montel
CONTEXT: The squat is a fundamental movement for weight lifting and sports performance. Both unilateral and bilateral squats are also used to assess transitional and dynamic lower extremity control. Common lower extremity conditions can have an influence on squat performance. Of interest, are the effects of hip musculoskeletal conditions and associated factors such as hip muscle pain, fatigue, and tightness on squat performance. Currently, there has been no appraisal of the evidence regarding the association of these conditions and associated factors on squat performance...
March 14, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28289873/patient-reported-outcomes-as-predictors-of-remission-in-early-rheumatoid-arthritis-patients-treated-with-tight-control-treat-to-target-approach
#7
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Timo Yli-Kerttula, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Identifying prognostic factors for remission in early rheumatoid arthritis (ERA) patients is of key clinical importance. We studied patient-reported outcomes (PROs) as predictors of remission in a clinical trial. We randomized 99 untreated ERA patients to receive remission-targeted treatment with three disease-modifying antirheumatic drugs and prednisolone for 24 months, and infliximab or placebo for the initial 6 months. At baseline, we measured following PROs: eight Short Form 36 questionnaire (SF-36) dimensions, patient's global assessment [PGA, visual analogue scale (VAS)], Health Assessment Questionnaire (HAQ), and pain VAS...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28284771/prevalence-of-musculoskeletal-manifestations-and-related-disabilities-in-a-peruvian-urban-population-living-at-high-altitude-copcord-study-stage-i
#8
Oscar Vega-Hinojosa, Mario H Cardiel, Pilar Ochoa-Miranda
OBJECTIVE: Estimate the prevalence of musculoskeletal manifestations and related disabilities of an urban population living at high altitude in Juliaca, Puno, Peru, using the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) questionnaire and Health Assessment Questionnaire (HAQ) disability index. METHODS: A cross-sectional study was performed in a sample of 1095 people. In each interview, the COPCORD methodology and the HAQ were applied. The city was divided into 8 sectors...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28279661/dynamic-balance-training-improves-physical-function-in-individuals-with-knee-osteoarthritis-a-pilot-randomized-controlled-trial
#9
Judit Takacs, Natasha M Krowchuk, S Jayne Garland, Mark G Carpenter, Michael A Hunt
OBJECTIVE: To examine the effect of a targeted balance training program on dynamic balance and self-reported physical function in people with medial tibiofemoral osteoarthritis (OA). DESIGN: A single-blind randomized controlled trial. SETTING: Exercise gymnasium and community dwellings. PARTICIPANTS: Forty individuals with medial compartment knee OA. INTERVENTION: Ten weeks of partially-supervised exercises targeting dynamic balance and strength performed four times per week, or no intervention (control group)...
March 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28276958/disease-activity-in-and-quality-of-life-of-patients-with-psoriatic-arthritis-mutilans-the-nordic-pam-study
#10
U Lindqvist, B Gudbjornsson, L Iversen, L Laasonen, L Ejstrup, T Ternowitz, M Ståhle
OBJECTIVE: To describe the social status and health-related quality of life of patients with psoriatic arthritis mutilans (PAM) in the Nordic countries. METHOD: Patients with at least one mutilated joint confirmed by radiology were studied. Disease activity involving joints and skin, physician-assessed disease activity, and patient's education and work status were recorded. Data from the 36-item Short Form Health Survey, Health Assessment Questionnaire and Dermatology Life Quality Index questionnaire were gathered and correlated with disease duration, pain, and general well-being (visual analogue scale)...
February 10, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28276735/differences-in-psychosocial-responses-to-pain-between-sufficiently-and-insufficiently-active-adults-with-arthritis
#11
Miranda A Cary, Danielle R Brittain, Nancy C Gyurcsik
OBJECTIVE: Adults with arthritis struggle to meet the physical activity recommendation for disease self-management. Identifying psychosocial factors that differentiate adults who meet (sufficiently active) or do not meet (insufficiently active) the recommendation is needed. This study sought to examine differences in psychosocial responses to arthritis pain among adults who were sufficiently or insufficiently active. DESIGN: This prospective study included adults with medically diagnosed arthritis (N = 136, Mage = 49...
March 6, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28265846/the-multifunctional-role-of-the-chemokine-system-in-arthritogenic-processes
#12
REVIEW
Giovanni Bernardini, Giorgia Benigni, Rossana Scrivo, Guido Valesini, Angela Santoni
PURPOSE OF REVIEW: The involvement of chemokines and their receptors in the genesis and perpetuation of rheumatoid arthritis, spondyloarthritis, and osteoarthritis has been clearly recognized for a long time. Nevertheless, the complexity of their contribution to these diseases is now becoming evident and this review focuses on published evidence on their mechanism of action. RECENT FINDINGS: Studies performed on patients and in vivo models have identified a number of chemokine-mediated pathways involved in various aspects of arthritogenic processes...
March 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28265549/antinociceptive-effect-of-extracts-of-marrubium-astracanicum-jacq-aerial-parts
#13
Niloofar Kahkeshani, Milad Gharedaghi, Abbas Hadjiakhoondi, Mohammad Sharifzadeh, Mahnaz Khanavi
OBJECTIVE: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum. MATERIALS AND METHODS: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice...
January 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28263785/nociceptive-neuronal-fc-gamma-receptor-i-is-involved-in-igg-immune-complex-induced-pain-in-the-rat
#14
Haowu Jiang, Xinhua Shen, Zhiyong Chen, Fan Liu, Tao Wang, Yikuan Xie, Chao Ma
Antigen-specific immune diseases such as rheumatoid arthritis are often accompanied by pain and hyperalgesia. Our previous studies have demonstrated that Fc-gamma-receptor type I (FcγRI) is expressed in a subpopulation of rat dorsal root ganglion (DRG) neurons and can be directly activated by IgG immune complex (IgG-IC). In this study we investigated whether neuronal FcγRI contributes to antigen-specific pain in the naïve and rheumatoid arthritis model rats. In vitro calcium imaging and whole-cell patch clamp recordings in dissociated DRG neurons revealed that only the small-, but not medium- or large-sized DRG neurons responded to IgG-IC...
March 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28258773/efficacy-of-celecoxib-for-early-postoperative-pain-management-in-hip-arthroscopy-a-prospective-randomized-placebo-controlled-study
#15
Cynthia A Kahlenberg, Ronak M Patel, Michael Knesek, Vehniah K Tjong, Kevin Sonn, Michael A Terry
PURPOSE: To determine whether 400 mg of celecoxib administered 1 hour before hip arthroscopy surgery would reduce pain, provide reduction in overall narcotic consumption, and lead to more rapid discharge from recovery rooms. METHODS: Ninety-eight patients were randomized to either the celecoxib group (n = 50) or the placebo group (n = 48). An a priori power analysis was done set to detect a difference of 0.50 on the visual analog scale (VAS), based on the senior author's preference...
February 28, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28251584/improvements-in-fatigue-in-1536-patients-with-rheumatoid-arthritis-and-correlation-with-other-treatment-outcomes-a-post-hoc-analysis-of-three-randomized-controlled-trials-of-abatacept
#16
Laure Gossec, Souhila Ahdjoudj, Evo Alemao, Vibeke Strand
INTRODUCTION: A post hoc analysis of three randomized controlled trials of abatacept in rheumatoid arthritis (RA) was conducted to explore the effect of abatacept on fatigue in RA and its correlation with other outcomes. METHODS: In this analysis of AGREE (early RA) and AIM and ATTAIN (established RA), changes in baseline fatigue (0-100 mm scale), pain, sleep (AIM and ATTAIN only) and Disease Activity Score (DAS) 28 (C-reactive protein; CRP) were calculated at days 29, 85, and 169...
March 1, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28248869/the-minimal-effective-dose-of-cis-9-cetylmyristoleate-cmo-in-persons-presenting-with-knee-joint-pain-a-double-blind-randomized-placebo-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Sang Chul Lee, Hyun Seung Jin, Young Joo, Yong Chul Kim, Jee Youn Moon
BACKGROUND: Nutraceuticals containing cis-9-cetylmyristoleate (CMO) are used to improve knee pain despite the lack of placebo-controlled studies in humans. The aim of the study was to explore the minimal effective dose of CMO for relieving knee joint pain. METHODS: Twenty-eight subjects with mild degree arthritic knee joint pain were randomized into 4 groups; groups A, B, and C that contained 100%, 80%, and 62.4% of fatty acid component with 12.5% of CMO, and control group D (starch 100%)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28246126/effect-of-disease-related-changes-in-plasma-albumin-on-the-pharmacokinetics-of-naproxen-in-male-and-female-arthritic-rats
#18
Xiaonan Li, Debra C DuBois, Richard R Almon, William J Jusko
Naproxen (NPX) is used in the treatment of rheumatoid arthritis (RA) for alleviation of pain and inflammation. In view of the extensive albumin binding of NPX, this study investigates whether chronic inflammation and sex will influence the physiological albumin concentrations, plasma protein binding, and pharmacokinetics (PK) of NPX. The PK of NPX was evaluated in a rat model of RA (collagen-induced arthritis (CIA) in Lewis rats) and in healthy controls. These PK studies included: 1) NPX in female and male CIA rats that received 10, 25 or 50 mg/kg NPX intraperitoneally (IP), and 2) NPX in healthy female and male rats after IP dosing of NPX at 50 mg/kg...
February 28, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28241215/effectiveness-of-an-internet-delivered-exercise-and-pain-coping-skills-training-intervention-for-persons-with-chronic-knee-pain-a-randomized-trial
#19
Kim L Bennell, Rachel Nelligan, Fiona Dobson, Christine Rini, Francis Keefe, Jessica Kasza, Simon French, Christina Bryant, Andrew Dalwood, J Haxby Abbott, Rana S Hinman
Background: Effective, accessible biopsychosocial treatments are needed to manage chronic knee pain on a population level. Objective: To evaluate the effectiveness of Internet-delivered, physiotherapist-prescribed home exercise and pain-coping skills training (PCST). Design: Pragmatic parallel-group randomized, controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12614000243617). Setting: Community (Australia)...
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28228115/weight-loss-and-exercise-for-communities-with-arthritis-in-north-carolina-we-can-design-and-rationale-of-a-pragmatic-assessor-blinded-randomized-controlled-trial
#20
Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt, Paul DeVita, David J Hunter, Mary F Lyles, Jovita Newman, Betsy Hackney, Joanne M Jordan
BACKGROUND: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown...
February 22, 2017: BMC Musculoskeletal Disorders
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