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pain control in arthritis

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https://www.readbyqxmd.com/read/27903009/temperature-controlled-continuous-cold-flow-device-after-total-knee-arthroplasty-a-randomized-controlled-trial-study
#1
Alberto Ruffilli, Francesco Castagnini, Francesco Traina, Isabella Corneti, Domenico Fenga, Sandro Giannini, Cesare Faldini
Total knee arthroplasty (TKA) is a widely accepted and successful procedure for end-stage arthritis. Nevertheless, fast-track may be compromised by many factors, such as pain, edema, and blood loss. Cryotherapy has been advocated as a safe and effective strategy to improve the postoperative results, acting on pain, edema, and blood loss. This study is a prospective randomized controlled study, involving 50 patients after primary TKA. A power analysis was performed preoperatively. Twenty-four patients were addressed to a postoperative treatment with a continuous cold flow device (Hilotherm, Hilotherm GmbH, Germany)...
November 30, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27893033/effect-of-a-decision-aid-on-access-to-total-knee-replacement-for-black-patients-with-osteoarthritis-of-the-knee-a-randomized-clinical-trial
#2
Said A Ibrahim, Marissa Blum, Gwo-Chin Lee, Pekka Mooar, Elina Medvedeva, Aliya Collier, Diane Richardson
Importance: Black patients with advanced osteoarthritis (OA) of the knee are significantly less likely than white patients to undergo surgery. No strategies have been proved to improve access to surgery for black patients with end-stage OA of the knee. Objective: To assess whether a decision aid improves access to total knee replacement (TKR) surgery for black patients with OA of the knee. Design, Setting, and Participants: In a randomized clinical trial, 336 eligible participants who self-identified as black and 50 years or older with chronic and frequent knee pain, a Western Ontario McMaster Universities Osteoarthritis Index score of at least 39, and radiographic evidence of OA of the knee were recruited from December 1, 2010, to May 31, 2014, at 3 medical centers...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27891180/the-effect-of-foot-orthoses-with-forefoot-cushioning-or-metatarsal-pad-on-forefoot-peak-plantar-pressure-in-running
#3
Michaela Hähni, Anja Hirschmüller, Heiner Baur
BACKGROUND: Foot orthoses are frequently used in sports for the treatment of overuse complaints with sufficient evidence available for certain foot-related overuse pathologies like plantar fasciitis, rheumatoid arthritis and foot pain (e.g., metatarsalgia). One important aim is to reduce plantar pressure under prominent areas like metatarsal heads. For the forefoot region, mainly two common strategies exist: metatarsal pad (MP) and forefoot cushioning (FC). The aim of this study was to evaluate which of these orthosis concepts is superior in reducing plantar pressure in the forefoot during running...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/27886163/alghedon-fentanyl-transdermal-system-afts
#4
Patrizia Romualdi, Patrizia Santi, Sanzio Candeletti
The efficacy of transdermal fentanyl for cancer pain and chronic non-cancer pain (chronic lower back pain, rheumatoid arthritis, osteoarthritis, neuropathic pain) is well established. Several formulations of fentanyl transdermal systems have been developed to improve the drug delivery and prevent misuse of the active principle. The addition of a rate controlling membrane to the matrix system represented an important advance. The design and functional features of Alghedon patch are compared with other approved generic fentanyl transdermal systems, emphasizing the distinctiveness of Alghedon patch...
November 25, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27876489/morphologic-changes-and-outcomes-after-arthroscopic-acetabular-labral-repair-evaluated-using-postoperative-computed-tomography-arthrography
#5
Jun-Il Yoo, Yong-Chan Ha, Young-Kyun Lee, Guen-Young Lee, Moon-Jib Yoo, Kyung-Hoi Koo
PURPOSE: To investigate smaller sized labra after acetabular labral repair comparing preoperative and postoperative computed tomography arthrography (CTA) and to assess the correlation between the anatomic changes and clinical outcomes. METHODS: The design and protocol of this retrospective study were approved by the institutional review board of our hospital. The inclusion criteria included age older than 18 years and hip pain associated with mechanical symptoms...
November 19, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27872515/therapeutic-treatment-of-arthritic-mice-with-15-deoxy-%C3%AE-12-14-prostaglandin-j2-15d-pgj2-ameliorates-disease-through-the-suppression-of-th17-cells-and-the-induction-of-cd4-cd25-foxp3-cells
#6
Vanessa Carregaro, Marcelo H Napimoga, Raphael S Peres, Luciana Benevides, Laís Amorim Sacramento, Larissa G Pinto, Renata Grespan, Thiago M Cunha, João Santana da Silva, Fernando Q Cunha
The prostaglandin, 15-deoxy Δ(12,14)-prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ2 in an experimental model of arthritis. Daily administration of 15d-PGJ2 attenuated the severity of CIA, reducing the clinical score, pain, and edema. 15d-PGJ2 treatment was associated with a marked reduction in joint levels of proinflammatory cytokines...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27871281/physical-multimorbidity-and-psychosis-comprehensive-cross-sectional-analysis-including-242-952-people-across-48-low-and-middle-income-countries
#7
Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F Carvalho, John Lally, Alex J Mitchell, James Mugisha, Christoph U Correll
BACKGROUND: In people with psychosis, physical comorbidities, including cardiovascular and metabolic diseases, are highly prevalent and leading contributors to the premature mortality encountered. However, little is known about physical health multimorbidity in this population or in people with subclinical psychosis and in low- and middle-income countries (LMICs). This study explores physical health multimorbidity patterns among people with psychosis or subclinical psychosis. METHODS: Overall, data from 242,952 individuals from 48 LMICs, recruited via the World Health Survey, were included in this cross-sectional study...
November 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27855775/use-of-closed-suction-drain-after-primary-total-knee-arthroplasty-an-overrated-practice
#8
Gaurav M Sharma, Gauresh Palekar, Dilip D Tanna
PURPOSE: The age-old practice of closed suction drain following orthopedic procedures has been challenged since past few decades. Our aim was to assess the effectiveness of closed suction drain after total knee arthroplasty. MATERIALS AND METHODS: One hundred twenty patients (135 knees) with primary Total Knee Arthroplasty were divided into a study group (no drain) and a control group (drain used). Inclusion criteria were grade 3 and grade 4 osteoarthritis of the knee...
2016: SICOT-J
https://www.readbyqxmd.com/read/27852301/sleep-quality-in-chinese-patients-with-rheumatoid-arthritis-contributing-factors-and-effects-on-health-related-quality-of-life
#9
Genkai Guo, Ting Fu, Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Yunfei Xia, Liren Li, Zhifeng Gu
BACKGROUND: Poor sleep quality is common in rheumatoid arthritis (RA) patients and may lead to disease aggravation and decreased health-related quality of life (HRQoL). The increasing prevalence of poor sleep in RA patients is associated with adverse demographic, clinical, and psychological characteristics. However, there are currently no known reported studies related to the effects of sleep quality on HRQoL in RA patients from China. This cross-sectional study aims to evaluate the contributors of poor sleep and the effects of sleep quality on HRQoL in Chinese RA patients...
November 16, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27847529/update-on-the-clinical-effect-of-acupuncture-therapy-in-patients-with-gouty-arthritis-systematic-review-and-meta-analysis
#10
REVIEW
Wei-Wei Lu, Jin-Ming Zhang, Zheng-Tao Lv, An-Min Chen
Objective. The aim of this study is to evaluate the clinical efficacy and safety of acupuncture therapy in the treatment of acute gouty arthritis. Methods. A literature search of PubMed, EMBASE, ISI Web of Science, CENTRAL, and CNKI was conducted from the inception date of each database up to October 2015. Two investigators screened each article independently and were blinded to the findings of the other reviewer. Data was extracted according to the predetermined collection form. Meta-analysis was performed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27825572/cryotherapy-decreases-synovial-doppler-activity-and-pain-in-knee-arthritis-a-randomized-controlled-trial
#11
Xavier Guillot, Nicolas Tordi, Clément Prati, Frank Verhoeven, Lionel Pazart, Daniel Wendling
OBJECTIVE: To measure and compare the effects of 2 local cryotherapy techniques on synovial power Doppler activity (primary outcome) and pain in non-septic knee arthritis without any concurrent treatment. METHODS: 30 patients were randomized (ice: 30min, n=15 or cold CO2: 2min, n=15 both applied twice at 8h interval). Contralateral non-treated arthritic knees were used as paired controls (n=11 and n=10 respectively). The PDUS semi-quantitative score (0-3) and pain visual analogic scale were evaluated before/after each cold application, 2min, 2h, 24h after the first application...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27824657/effect-of-footwear-on-joint-pain-and-function-in-older-adults-with-lower-extremity-osteoarthritis
#12
Amy Wagner, Sarah Luna
BACKGROUND AND PURPOSE: Lower extremity osteoarthritis (OA) is a common condition among older adults; given the risks of surgical and pharmaceutical interventions, conservative, lower-cost management options such as footwear warrant further investigation. This systematic review investigated the effects of footwear, including shoe inserts, in reducing lower extremity joint pain and improving gait, mobility, and quality of life in older adults with OA. METHODS: The CINAHL, SPORTDiscus, PubMed, RECAL, and Web of Knowledge databases were searched for publications from January 1990 to September 2014, using the terms "footwear," "shoes," "gait," "pain," and "older adult...
November 7, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27821962/the-effects-of-exercise-on-the-gap-43-expression-in-the-spinal-cord-of-arthritis-induced-rats
#13
Soo-Jin Park, Nam-Jin Jung, Sang-Su Na
[Purpose] The purpose of the study was to investigate the effects of exercise on the recovery of spinal cord nerve cells damaged due to pain signals which are a major symptom of osteoarthritis. [Subjects and Methods] Adult male Sprague-Dawley rats (n=40) were used and induction of osteoarthritis by monosodium iodoacetate. Injected rats were randomly divided into 4 groups: Sham control group without MIA injection (SG), control group with injected MIA (CG), OA without exercise (NEG), OA with exercise (EG). Sham control group was injected normal cell line instead of MIA...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27820818/increased-serum-levels-of-il-17a-and-il-23-are-associated-with-decreased-vitamin-d3-and-increased-pain-in-osteoarthritis
#14
Alireza Askari, Mohammad Mehdi Naghizadeh, Reza Homayounfar, Abbas Shahi, Mohammad Hosein Afsarian, Abbas Paknahad, Derek Kennedy, Mohammad Reza Ataollahi
INTRODUCTION: Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and their relation to vitamin D3 and pain. MATERIAL AND METHODS: The sera from 131 patients with OA and 262 healthy controls were evaluated for serum levels of IL-17A, IL-21, IL-23 and vitamin D3 using ELISA...
2016: PloS One
https://www.readbyqxmd.com/read/27815104/characteristic-magnetic-resonance-imaging-findings-in-rheumatoid-arthritis-of-the-temporomandibular-joint-focus-on-abnormal-bone-marrow-signal-of-the-mandibular-condyle-pannus-and-lymph-node-swelling-in-the-parotid-glands
#15
Naohisa Hirahara, Takashi Kaneda, Hirotaka Muraoka, Taiga Fukuda, Kotaro Ito, Yusuke Kawashima
PURPOSE: The purpose of this study was to determine the characteristic magnetic resonance imaging (MRI) findings indicating bone and soft tissue involvement in patients with rheumatoid arthritis (RA) of the temporomandibular joints (TMJs). PATIENTS AND METHODS: Twenty-one patients with RA and TMJ pain who underwent MRI examination of the TMJs at the authors' hospital from August 2006 to December 2014 were included in this study. Twenty-two patients with normal TMJs who underwent MRI examination at the authors' hospital from November to December 2014 were included as controls...
October 7, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27812955/differential-effects-of-inflammation-on-bone-and-response-to-biologics-in-rheumatoid-arthritis-and-spondyloarthritis
#16
REVIEW
Zheni Stavre, Katherine Upchurch, Jonathan Kay, Ellen M Gravallese
PURPOSE OF REVIEW: We review the pathways, cytokines, and concepts important to the pathogenesis of bone resorption and formation in rheumatoid arthritis (RA) and spondyloarthritis (SpA). RECENT FINDINGS: Research in bone biology has shed light on the pathogenesis of the joint destruction that occurs in RA and in peripheral SpA. However, understanding the mechanisms behind the bone formation seen in peripheral and axial SpA has been challenging. Mouse models have been used to gain an understanding of key signaling pathways, cytokines and cells regulating inflammation in these diseases...
December 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27811267/pain-regulation-by-non-neuronal-cells-and-inflammation
#17
REVIEW
Ru-Rong Ji, Alexander Chamessian, Yu-Qiu Zhang
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial cells, keratinocytes, cancer cells, and stem cells play active roles in the pathogenesis and resolution of pain. We review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling molecules that modulate pain...
November 4, 2016: Science
https://www.readbyqxmd.com/read/27802478/management-of-gout-a-systematic-review-in-support-of-an-american-college-of-physicians-clinical-practice-guideline
#18
Paul G Shekelle, Sydne J Newberry, John D FitzGerald, Aneesa Motala, Claire E O'Hanlon, Abdul Tariq, Adeyemi Okunogbe, Dan Han, Roberta Shanman
Background: Gout is a common type of inflammatory arthritis in patients seen by primary care physicians. Purpose: To review evidence about treatment of acute gout attacks, management of hyperuricemia to prevent attacks, and discontinuation of medications for chronic gout in adults. Data Sources: Multiple electronic databases from January 2010 to March 2016, reference mining, and pharmaceutical manufacturers. Study Selection: Studies of drugs approved by the U...
November 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27777815/the-prevalence-of-pisotriquetral-arthritis-in-the-setting-of-scapholunate-advanced-collapse
#19
Schneider K Rancy, Samir K Trehan, Angela E Li, Steve K Lee, Hollis G Potter, Scott W Wolfe
Background Previous authors have reported pisotriquetral pain and subsequent pisiform excision following partial or total wrist fusion in patients with scapholunate advanced collapse (SLAC). Prior studies have not considered the potential role of SLAC biomechanics on pisotriquetral osteoarthritis (PT OA) development preoperatively. Purpose To determine the prevalence and severity of PT OA in patients with SLAC as compared with a control population. Patients and Methods Magnetic resonance imaging (MRI) studies of 24 patients with SLAC wrist and 24 sex- and age-matched control patients were analyzed...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27776949/beh%C3%A3-et-s-disease%C3%A2-and-fmf-two-sides-of-the-same-coin-or-just-an-association-a-cross-sectional-study%C3%A2
#20
Abdulla Watad, Shmuel Tiosano, Dana Yahav, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Familial Mediterranean fever (FMF) is a genetic disease, characterized by attacks of fever, arthritis, serositis and pain. Behçet's disease (BD) is an inflammatory disorder with a genetic basis, characterized by oral and genital ulcers, uveitis, pustular erythematous cutaneous lesions, arthritis, central nervous system involvement and possible vascular manifestations such as venous thrombosis, arteritis and aneurysms. OBJECTIVES: To investigate the association and actual differentiation between these two entities in a large-scale population-based study...
October 21, 2016: European Journal of Internal Medicine
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