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pain control in arthritis

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https://www.readbyqxmd.com/read/28917375/total-glucosides-of-paeony-for-rheumatoid-arthritis-a-systematic-review-of-randomized-controlled-trials
#1
REVIEW
Jing Luo, Di-Er Jin, Guo-Yan Yang, Ying-Ze Zhang, Jian-Ming Wang, Wei-Ping Kong, Qing-Wen Tao
BACKGROUND: Total glucosides of paeony (TGP) is commonly used to treat rheumatoid arthritis (RA) in China. However, clinical practice hasn't been well informed by evidence from appropriately conducted systematic reviews. This PRISMA-compliant systematic review aims at examining the effectiveness and safety of TGP for RA. METHODS: Randomized controlled trials (RCTs) comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs (DMARDs) for patients with RA were retrieved by searching seven databases...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28914380/secretory-sphingomyelinase-s-smase-activity-is-elevated-in-patients-with-rheumatoid-arthritis
#2
Beatriz Y Hanaoka, Michelle J Ormseth, C Michael Stein, Daipayan Banerjee, Mariana Nikolova-Karakashian, Leslie J Crofford
The goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected data on 33 patients who were diagnosed with RA and 17 non-RA controls who were comparable in terms of age, sex, and race. Demographic, clinical data and self-reported measures of fatigue, pain, and physical function were obtained directly from patients and controls...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28910372/correlation-of-serum-cartilage-oligometric-matrix-protein-comp-and-interleukin-16-il-16-levels-with-disease-severity-in-primary-knee-osteoarthritis-a-pilot-study-in-a-malaysian-population
#3
Esha Das Gupta, Wei Ren Ng, Shew Fung Wong, Abdul Kareem Bhurhanudeen, Swan Sim Yeap
OBJECTIVE: The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. METHODS: Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28906437/developing-fine-grained-actigraphies-for-rheumatoid-arthritis-patients-from-a-single-accelerometer-using-machine-learning
#4
Javier Andreu-Perez, Luis Garcia-Gancedo, Jonathan McKinnell, Anniek Van der Drift, Adam Powell, Valentin Hamy, Thomas Keller, Guang-Zhong Yang
In addition to routine clinical examination, unobtrusive and physical monitoring of Rheumatoid Arthritis (RA) patients provides an important source of information to enable understanding the impact of the disease on quality of life. Besides an increase in sedentary behaviour, pain in RA can negatively impact simple physical activities such as getting out of bed and standing up from a chair. The objective of this work is to develop a method that can generate fine-grained actigraphies to capture the impact of the disease on the daily activities of patients...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28893676/rationale-and-design-of-the-staying-positive-with-arthritis-spa-study-a-randomized-controlled-trial-testing-the-impact-of-a-positive-psychology-intervention-on-racial-disparities-in-pain
#5
Leslie R M Hausmann, Said A Ibrahim, C Kent Kwoh, Ada Youk, D Scott Obrosky, Debra K Weiner, Ernest Vina, Rollin M Gallagher, Genna T Mauro, Acacia Parks
Knee osteoarthritis is a painful, disabling condition that disproportionately affects African Americans. Existing arthritis treatments yield small to moderate improvements in pain and have not been effective at reducing racial disparities in the management of pain. The biopsychosocial model of pain and evidence from the positive psychology literature, suggest that increasing positive psychological skills (e.g., gratitude, kindness) could improve pain and functioning and reduce disparities in osteoarthritis pain management...
September 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28892928/anti-inflammatory-and-analgesic-activities-of-topical-formulations-of-pterocarpus-santalinus-powder-in-rat-model-of-chronic-inflammation
#6
Priti Pravin Dhande, Amit O Gupta, Sourav Jain, Jayshree Shriram Dawane
INTRODUCTION: The incidence of arthritis is quite high and there is a need for the search of natural products to halt the progression of disease or provide symptomatic relief without significant adverse effects. AIM: This study aimed at evaluating the anti-inflammatory and analgesic activities of topical Pterocarpus santalinus in an animal model of chronic inflammation. MATERIALS AND METHODS: Albino rats of either sex were divided into five groups of six rats each (Group I - Control, Group II -Gel base, Group III -P...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891302/gastrocnemius-contracture-in-patients-with-rheumatoid-arthritis
#7
James R Jastifer, Adam Green
BACKGROUND: Rheumatoid arthritis is a chronic disease affecting multiple joints of the body. More than 90% of patients affected by rheumatoid arthritis develop foot or ankle pain over the course of their disease. The purpose of the current study was to report ankle dorsiflexion in rheumatoid arthritis patients as well as a control group utilizing a validated measurement instrument. METHODS: Using a previously validated device, 70 patients presenting with rheumatoid arthritis and 70 controls were measured for ankle range motion and isolated gastrocnemius contractures...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28884785/certolizumab-pegol-cdp870-for-rheumatoid-arthritis-in-adults
#8
REVIEW
Vicente Ruiz Garcia, Amanda Burls, Juan B Cabello, Paloma Vela Casasempere, Sylvia Bort-Marti, José A Bernal
BACKGROUND: Tumour necrosis factor (TNF)-alpha inhibitors are beneficial for the treatment of rheumatoid arthritis (RA) for reducing the risk of joint damage, improving physical function and improving the quality of life. This review is an update of the 2014 Cochrane Review of the treatment of RA with certolizumab pegol. OBJECTIVES: To assess the clinical benefits and harms of certolizumab pegol (CZP) in people with RA who have not responded well to conventional disease-modifying anti-rheumatic drugs (DMARDs)...
September 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28884308/spa-therapy-adjunct-to-pharmacotherapy-is-beneficial-in-rheumatoid-arthritis-a-crossover-randomized-controlled-trial
#9
Mine Karagülle, Sinan Kardeş, Rian Dişçi, Müfit Zeki Karagülle
This study aims to investigate whether 2-week spa therapy, as an adjunct to usual pharmacological therapy, has any beneficial effect in patients with rheumatoid arthritis (RA). In this single-blind crossover study, 50 patients were randomly assigned in a 1:1 manner to receive usual pharmacological therapy plus 2-week spa therapy or usual pharmacological therapy alone (period 1.6 months); after a 9-month washout, patients were crossed over to the opposite assignment (period 2.6 months). Spa therapy program included a daily saline balneotherapy session at 36-37 °C for 20 min except Sundays...
September 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28880707/relationship-between-achievement-of-physical-activity-goal-and-characteristics-of-patients-with-rheumatoid-arthritis
#10
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Kosei Kawakami, Ryo Hiroshima, Shigeki Momohara
OBJECTIVES: We aimed to identify the relationship between achievement of a physical activity goal and the characteristics of patients with rheumatoid arthritis (RA). METHODS: Overall, 137 patients with RA who performed physical activity were enrolled. Statistical analysis was performed to examine relationship between patient characteristics and achievement of physical activity goal by univariate analysis, multivariate logistic regression analysis and the receiver operating characteristic method...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28877850/gabapentin-regulates-expression-of-fgf2-and-fgfr1-in-dorsal-root-ganglia-via-microrna-15a-in-the-arthritis-rat-model
#11
Dexu Sun, Junxia Yang, Deguang Wang, Xiangyang Li, Lin Wang, Qian Yu, Suping Qin, Renxian Tang
BACKGROUND: Arthritis is an inflammatory disease with a prevalence rate of approximately 10% in China, which commonly manifests as pain. The aim of the current study was to investigate the function of gabapentin in the dorsal root ganglion in an arthritis rat model, and assess the effect of gabapentin on the expression of fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1). METHODS: A total of 30 healthy male Sprague-Dawley rats were randomly divided into the following three groups: Untreated group, control group and gabapentin group...
September 3, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28874641/intricate-estimation-and-evaluation-of-mandibular-movements-in-geriatric-patients-suffering-from-rheumatoid-arthritis
#12
Shruti Dev, Sonali Perti, Mirna Garhnayak, Kalinga K Sahoo, Angurbala Dhal, Lokanath Garhnayak
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disorder that usually affects joints and making them warm, painful, and swollen. The chief purpose of this study was to evaluate movements of mandible in geriatric patients suffering from RA with or without temporomandibular joint dysfunction. MATERIALS AND METHODS: A total of 45 people were included in this study with age of 60 years and above. Partially or completely edentulous patients were divided into experimental and control group...
September 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28874151/effects-of-mollugo-pentaphylla-extract-on-monosodium-urate-crystal-induced-gouty-arthritis-in-mice
#13
Yun Mi Lee, Eun-Jung Shon, Ohn Soon Kim, Dong-Seon Kim
BACKGROUND: Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. METHOD: An MSU crystal suspension (4 mg/50 μL) was injected intradermally into the right paw...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28869185/gait-variability-and-motor-control-in-patients-with-knee-osteoarthritis-as-measured-by-the-uncontrolled-manifold-technique
#14
Gwenllian Fflur Tawy, Philip Rowe, Leela Biant
Knee osteoarthritis (OA) causes pain, reduced muscular strength and stiffness of the affected joint. In response, the motor control mechanism is altered, potentially compromising stability during acts of daily living. Reduced walking stability can be quantified in terms of gait variability. This study therefore aimed to identify and quantify the effects of knee arthritis on gait variability. Fifty adults (25 males/25 females) with end-stage OA of the knee sufficiently symptomatic to require joint replacement, walked on a self-paced treadmill for 2min...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28862129/duration-of-intravenous-antibiotic-therapy-for-children-with-acute-osteomyelitis-or-septic-arthritis-a-feasibility-study
#15
Hans de Graaf, Priya Sukhtankar, Barbara Arch, Nusreen Ahmad, Amanda Lees, Abigail Bennett, Catherine Spowart, Helen Hickey, Annmarie Jeanes, Kate Armon, Andrew Riordan, Jethro Herberg, Scott Hackett, Carrol Gamble, Delane Shingadia, Ann Pallett, Stuart C Clarke, Philip Henman, Marieke Emonts, Mike Sharland, Adam Finn, Andrew J Pollard, Colin Powell, Peter Marsh, Claire Ballinger, Paula R Williamson, Nicholas Mp Clarke, Saul N Faust
BACKGROUND: There is little current consensus regarding the route or duration of antibiotic treatment for acute osteomyelitis (OM) and septic arthritis (SA) in children. OBJECTIVE: To assess the overall feasibility and inform the design of a future randomised controlled trial (RCT) to reduce the duration of intravenous (i.v.) antibiotic use in paediatric OM and SA. DESIGN: (1) A prospective service evaluation (cohort study) to determine the current disease spectrum and UK clinical practice in paediatric OM/SA; (2) a prospective cohort substudy to assess the use of targeted polymerase chain reaction (PCR) in diagnosing paediatric OM/SA; (3) a qualitative study to explore families' views and experiences of OM/SA; and (4) the development of a core outcome set via a systematic review of literature, Delphi clinician survey and stakeholder consensus meeting...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28859685/an-umbrella-review-of-the-literature-on-the-effectiveness-of-psychological-interventions-for-pain-reduction
#16
Georgios Markozannes, Eleni Aretouli, Evangelia Rintou, Elena Dragioti, Dimitrios Damigos, Evangelia Ntzani, Evangelos Evangelou, Konstantinos K Tsilidis
BACKGROUND: Psychological interventions are widely implemented for pain management and treatment, but their reported effectiveness shows considerable variation and there is elevated likelihood for bias. METHODS: We summarized the strength of evidence and extent of potential biases in the published literature of psychological interventions for pain treatment using a range of criteria, including the statistical significance of the random effects summary estimate and of the largest study of each meta-analysis, number of participants, 95% prediction intervals, between-study heterogeneity, small-study effects and excess significance bias...
August 31, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28846633/strawberries-improve-pain-and-inflammation-in-obese-adults-with-radiographic-evidence-of-knee-osteoarthritis
#17
Jace Schell, R Hal Scofield, James R Barrett, Biji T Kurien, Nancy Betts, Timothy J Lyons, Yan Daniel Zhao, Arpita Basu
Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee...
August 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28840151/epidemiology-of-navicular-injury-at-the-nfl-combine-and-their-impact-on-an-athlete-s-prospective-nfl-career
#18
Bryan Vopat, Brendin R Beaulieu-Jones, Gregory Waryasz, Kevin J McHale, George Sanchez, Catherine A Logan, James M Whalen, Christopher W DiGiovanni, Matthew T Provencher
BACKGROUND: Navicular injuries can result in persistent pain, posttraumatic osteoarthritis, and diminished performance and function. PURPOSE: To determine the epidemiology of navicular fracture in players participating in the National Football League (NFL) Scouting Combine and evaluate the impact of a navicular injury on the NFL draft position and NFL game play compared with matched controls. STUDY DESIGN: Cohort study; Level of evidence, 3...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28827806/the-association-between-observed-mobility-and-quality-of-life-in-the-near-elderly
#19
Jason Shafrin, Jeff Sullivan, Dana P Goldman, Thomas M Gill
INTRODUCTION: Chronic diseases associated with aging, such as arthritis, frequently cause reduced mobility, pain and diminished quality of life. To date, research on the association between mobility and quality of life has primarily focused in the elderly; hence, much less is known about this association in the near elderly. This cross-sectional study aimed to assess the association between mobility and quality of life measures in the near elderly. METHODS: A prospective observational study of persons aged 50-69 years was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28817199/exposure-response-modeling-and-power-analysis-of-components-of-acr-response-criteria-in-rheumatoid-arthritis-part-1-binary-model
#20
Liang Li, Yi Zhang, Lian Ma, Ping Ji, Sarah Yim, Badrul Chowdhury, Suresh Doddapaneni, Jiang Liu, Yaning Wang, Chandrahas Sahajwalla
American College of Rheumatology (ACR) response criteria is used to assess improvement in tender and swollen joint counts and in 3 of the 5 core measures (acute-phase reactant, physician global assessment, patient global assessment, pain, and physical function). From the clinical trial data on 5 approved biological products for the treatment of rheumatoid arthritis, population pharmacokinetic/pharmacodynamic models were developed to quantitatively describe the relationship between exposure and response rates of 3 individual components of ACR response criteria...
September 2017: Journal of Clinical Pharmacology
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