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https://www.readbyqxmd.com/read/28340154/irradiation-strongly-reduces-tumorigenesis-of-human-induced-pluripotent-stem-cells
#1
Shoki Inui, Kazumasa Minami, Emiko Ito, Hiromasa Imaizumi, Seiji Mori, Masahiko Koizumi, Satsuki Fukushima, Shigeru Miyagawa, Yoshiki Sawa, Nariaki Matsuura
Induced pluripotent stem (iPS) cells have demonstrated they can undergo self-renewal, attain pluripotency, and differentiate into various types of functional cells. In clinical transplantation of iPS cells, however, a major problem is the prevention of tumorigenesis. We speculated that tumor formation could be inhibited by means of irradiation. Since the main purpose of this study was to explore the prevention of tumor formation in human iPS (hiPS) cells, we tested the effects of irradiation on tumor-associated factors such as radiosensitivity, pluripotency and cell death in hiPS cells...
March 3, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28327166/arthroscopic-findings-of-a-diagnostic-dilemma-hip-pathology-with-normal-imaging
#2
Joel Glenn Buikstra, Camdon Fary, Phong Tran
BACKGROUND: Patients with groin, hip and pelvic pain but normal findings on MRI and minimal changes on x-ray can be a diagnostic problem. This paper looks at the arthroscopic findings of patients who have had hip pain and a positive response to an intra-articular anaesthetic but have non-contributory imaging. We hypothesized that standard MRI's were missing significant pathology and if there was a response to intra-articular local anaesthesia, pathology found during arthroscopy was likely...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28321422/autologous-tenocyte-injection-for-the-treatment-of-chronic-recalcitrant-gluteal-tendinopathy-a-prospective-pilot-study
#3
Thomas A Bucher, Jay R Ebert, Anne Smith, William Breidahl, Michael Fallon, Tao Wang, Ming-Hao Zheng, Gregory C Janes
BACKGROUND: Gluteal tendinopathy is a common cause of lateral hip pain, and existing conservative treatment modalities demonstrate high symptom recurrence rates. Autologous tenocyte injection (ATI) is a promising cell therapy that may be useful for the treatment of gluteal tendinopathy. PURPOSE: To investigate the safety and effectiveness of ATI, specifically in patients with chronic recalcitrant gluteal tendinopathy. STUDY DESIGN: Case series; Level of evidence, 4...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319822/comparison-of-intravenous-versus-topical-tranexamic-acid-in-primary-total-hip-and-knee-arthroplasty-an-updated-meta-analysis
#4
REVIEW
Jinwei Xie, Qinsheng Hu, Qiang Huang, Jun Ma, Yiting Lei, Fuxing Pei
BACKGROUND: The appropriate route for administering tranexamic acid in primary total hip (THA) and knee arthroplasty (TKA) remains controversial. The purpose of this meta-analysis was to compare the efficacy and safety of topical or intravenous tranexamic acid. METHODS: PubMed, EMBASE, and the Cochrane Library databases were systematically searched for randomized controlled trials (RCTs) comparing topical and intravenous tranexamic acid following primary THA or TKA...
March 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#5
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28302115/arthroscopic-release-using-f-and-c-method-versus-conventional-open-release-method-in-the-treatment-of-gluteal-muscle-contracture-a-comparative-study
#6
Saroj Rai, Shengyang Jin, Chunqing Meng, Nabin Chaudhary, Nira Tamang, Xiaohong Wang, Xianzhe Liu, Hong Wang, Shuhua Yang
BACKGROUND: Gluteal muscle contracture (GMC), a debilitating disease, usually starts in early childhood after variable dose of injections around the buttock, if left untreated it worsens gradually and persists throughout the life. Because the disease mostly affects adolescents and adults, there is always an aesthetic concerns. Purposeof the study was to introduce the arthroscopic F and C method of GMC release, and to compare its clinical efficiency with conventional open surgery in terms of clinical outcome, rate of complications, patient's satisfactions, and recurrence...
March 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28290232/retention-of-human-induced-pluripotent-stem-cells-hips-with-injectable-ha-hydrogels-for-vocal-fold-engineering
#7
Mitsuyoshi Imaizumi, Nicole Y K Li-Jessen, Yuka Sato, David T Yang, Susan L Thibeault
OBJECTIVE: One prospective treatment option for vocal fold scarring is regeneration with an engineered scaffold containing induced pluripotent stem cells (iPS). In the present study, we investigated the feasibility of utilizing an injectable hyaluronic acid (HA) scaffold encapsulated with human-iPS cell (hiPS) for regeneration of vocal folds. METHODS: Thirty athymic nude rats underwent unilateral vocal fold injury. Contralateral vocal folds served as uninjured controls...
April 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28284945/fish-oil-prevents-rodent-anxious-states-comorbid-with-diabetes-a-putative-involvement-of-nitric-oxide-modulation
#8
Isadora Pozzetti Siba, Mariza Bortolanza, Maria Aparecida Barbato Frazão Vital, Roberto Andreatini, Joice Maria da Cunha, Elaine Aparecida Del Bel, Janaína Menezes Zanoveli
There is an urgent need to understand the pathophysiological mechanisms related to anxiety associated with diabetes, seeking more effective alternative treatments to treat it. For that, the effect of a preventive and prolonged treatment with fish oil (FO), a source of omega-3 polyunsaturated fatty acid, was tested in streptozotocin-diabetic (DBT) rats submitted to the anxiety tests. Additionally, an immunohistochemistry for neuronal NO synthase (nNOS) was performed in brain areas related to anxiety, such as lateral amygdala (AMY), hippocampus (HIP) and dorsolateral periaqueductal gray (dlPAG)...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28280738/ultrasound-guided-obturator-nerve-block-a-focused-review-on-anatomy-and-updated-techniques
#9
REVIEW
Takayuki Yoshida, Tatsuo Nakamoto, Takahiko Kamibayashi
This review outlines the anatomy of the obturator nerve and the indications for obturator nerve block (ONB). Ultrasound-guided ONB techniques and unresolved issues regarding these procedures are also discussed. An ONB is performed to prevent thigh adductor jerk during transurethral resection of bladder tumor, provide analgesia for knee surgery, treat hip pain, and improve persistent hip adductor spasticity. Various ultrasound-guided ONB techniques can be used and can be classified according to whether the approach is distal or proximal...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28273627/ventrogluteal-versus-dorsogluteal-site-selection-a-cross-sectional-study-of-muscle-and-subcutaneous-fat-thicknesses-and-an-algorithm-incorporating-demographic-and-anthropometric-data-to-predict-injection-outcome
#10
Theresa A Larkin, Elfriede Ashcroft, Asmahan Elgellaie, Blake A Hickey
BACKGROUND: The dorsogluteal and ventrogluteal intramuscular injection sites both have their use in clinical practice; however, it has not been established in whom one or the other should be preferentially targeted or avoided. There is a need for an evidence-based approach towards site selection for a successful intramuscular injection outcome and to avoid unwanted injection outcomes of inadvertent subcutaneous injection or bone contact. Injection outcome is dependent on injection site subcutaneous fat thickness and muscle thickness; these are likely influenced by gender and anthropometry...
February 22, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28270399/tuberculous-periprosthetic-infection-precipitated-by-infliximab-therapy
#11
Rajesh Malhotra, Deepak Gautam, Naman Wahal
Biological therapy with TNF-α inhibitors have been increasingly used in the treatment of inflammatory arthritis. Systemic tuberculosis infections are often known to occur following treatment with these biological agents. However, no case of periprosthetic tuberculous infection of the hip following this therapy has been reported. We report a case of a 45-year-old man who developed periprosthetic tuberculous infection soon after infliximab injection. We also discuss the need of pretreatment awareness, high index of suspicion, early diagnosis and management of such case...
March 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28265718/cost-effectiveness-analysis-of-once-yearly-injection-of-zoledronic-acid-for-the-treatment-of-osteoporosis-in-japan
#12
K Moriwaki, M Mouri, H Hagino
Model-based economic evaluation was performed to assess the cost-effectiveness of zoledronic acid. Although zoledronic acid was dominated by alendronate, the incremental quality-adjusted life year (QALY) was quite small in extent. Considering the advantage of once-yearly injection of zoledronic acid in persistence, zoledronic acid might be a cost-effective treatment option compared to once-weekly oral alendronate. INTRODUCTION: The purpose of this study was to estimate the cost-effectiveness of once-yearly injection of zoledronic acid for the treatment of osteoporosis in Japan...
March 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28264554/hearing-improvement-in-a-j-mice-via-the-mouse-nerve-growth-factor
#13
Lixiang Gao, Ruli Ge, Gang Xie, Dandan Yao, Ping Li, Oumei Wang, Xiufang Ma, Fengchan Han
Objectives: To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. Methods: The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group (mNGF group) and a distilled water (for injection) treated group (control group). The mNGF dissolved in distilled water or distilled water alone was given to the mice once every other day from P7 by intramuscular injection in the hips. The otoprotective effects of mNGF in A/J mice were observed in a time course manner...
March 8, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28263244/a-cadaveric-study-of-ultrasound-guided-subpectineal-injectate-spread-around-the-obturator-nerve-and-its-hip-articular-branches
#14
Thomas D Nielsen, Bernhard Moriggl, Kjeld Søballe, Jens A Kolsen-Petersen, Jens Børglum, Thomas Fichtner Bendtsen
BACKGROUND AND OBJECTIVES: The femoral and obturator nerves are assumed to account for the primary nociceptive innervation of the hip joint capsule. The fascia iliaca compartment block and the so-called 3-in-1-block have been used in patients with hip fracture based on a presumption that local anesthetic spreads to anesthetize both the femoral and the obturator nerves. Evidence demonstrates that this presumption is unfounded, and knowledge about the analgesic effect of obturator nerve blockade in hip fracture patients presurgically is thus nonexistent...
March 3, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28257614/dry-needling-versus-cortisone-injection-in-the-treatment-of-greater-trochanteric-pain-syndrome-a-non-inferiority-randomized-clinical-trial
#15
Kindyle L Brennan, Bryce C Allen, Yolanda Munoz Maldonado
Study Design Prospective, randomized, partially-blinded. Background Greater trochanteric pain syndrome (GTPS) is the current terminology for what was once called greater trochanteric or sub-gluteal bursitis. Cortisone (corticosteroid) injections into the lateral hip is a traditionally accepted treatment for this condition. However, the effectiveness of injecting the bursa with steroids is increasingly being questioned, and an equally effective treatment with fewer adverse side-effects would be beneficial. Objective To investigate whether administration of dry needling (DN) is non-inferior to cortisone injections in reducing lateral hip pain and improving function in patients with GTPS...
March 3, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28244975/clinical-utility-of-99mtc-ubiquicidin-29-41-as-an-adjunct-to-bone-scan-in-differentiating-infected-versus-noninfected-loosening-of-prosthesis-before-revision-surgery
#16
Ajit S Shinto, Archana Mukherjee, Kamalaeshwaran Koramadai Karuppusamy, Jephy Joseph, Jyotsna Bhatt, Aruna Korde, Indira Upadhya, Chanda Arjun, Grace Samuel, Ashutosh Dash
PURPOSE: The aim of this study was to evaluate the utility of Tc-ubiquicidin (Tc-UBI) (29-41) as an adjunct to an methylene diphosphonate (MDP) bone scan in differentiating septic versus aseptic loosening in patients with painful prosthesis posted for revision surgery. PATIENTS AND METHODS: A two-vial cold kit of UBI (29-41) was prepared and utilized for the preparation of patient dose of Tc-UBI (29-41). Twenty two patients with painful hip or knee prosthesis and scheduled for revision surgery were included in the study...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28240756/assessment-and-therapeutic-choice-in-septic-arthritis-of-the-hip-in-an-intravenous-drug-abuser-case-report-at-14-years-follow-up-and-review-of-literature
#17
P Persiani, F M Ranaldi, O Mazza, A Calistri, M Bove, M Crostelli, C Villani
INTRODUCTION: Osteoarticular infections are found frequently in drug addicted individuals, representing one of the main reasons for their hospitalization. Through inoculation, the pathogenic agents can enter the individual's system directly through the skin or parenterally, transmitted, that is, through syringes and other objects used during such practice. In these particular conditions, or when the medical history is vague, a warranted suspicion and the execution of targeted research can help in the diagnosis of high-risk patients such as addicts...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28237216/multiple-hip-intra-articular-steroid-injections-increase-risk-of-periprosthetic-joint-infection-compared-with-single-injections
#18
Andrew W Chambers, Kyle W Lacy, Ming Han Lincoln Liow, John Paul M Manalo, Andrew A Freiberg, Young-Min Kwon
BACKGROUND: Patients with hip osteoarthritis often temporize their symptoms with multiple intra-articular steroid hip injections (IASHIs) before undergoing total hip arthroplasty (THA). Although there is recent evidence to suggest that IASHI can lead to an increased risk of future periprosthetic joint infection (PJI), the potential increase in risk of PJI after multiple IASHIs compared with single IASHI remains largely unknown. The aim of the study was to evaluate whether multiple IASHIs are associated with increased risk of PJI compared with single IASHI in THA patients...
January 30, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28235496/use-of-test-dose-allows-early-detection-of-subdural-local-anesthetic-injection-with-lumbar-plexus-block
#19
Bradley H Lee, Matthias Braehler
A 56year-old woman underwent a lumbar plexus block for a revision of a left total hip arthroplasty. During the block procedure, the needle was advanced over the transverse process and isolated quadriceps twitches were elicited. After administering a test dose of 3ml of 1.5% lidocaine, the patient developed loss of sensation in the L3-4 dermatomal distribution that progressed caudally to involve both legs followed by inability to move the left leg. The patient shortly thereafter became hypotensive and sensory block spread cephalad and peaked at C7 bilaterally suggesting possible subdural spread of local anesthetic...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28224075/endoscopic-trochanteric-bursectomy-and-iliotibial-band-release-for-persistent-trochanteric-bursitis
#20
Justin J Mitchell, Jorge Chahla, Alexander R Vap, Travis J Menge, Eduardo Soares, Jonathan M Frank, Chase S Dean, Marc J Philippon
Lateral hip pain associated with trochanteric bursitis is a common orthopedic condition, and can be debilitating in chronic or recalcitrant situations. Conservative management is the most common initial treatment and often results in resolution of symptoms and improved patient outcomes. These modalities include rest, activity modification, physical therapy, anti-inflammatory medication, or corticosteroid injections. However, there is a subset of patients in which symptoms persist despite exhaustive conservative modalities...
October 2016: Arthroscopy Techniques
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