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https://www.readbyqxmd.com/read/28537914/epigenomic-study-identifies-a-novel-mesenchyme-homeobox2-gli1-transcription-axis-involved-in-cancer-drug-resistance-overall-survival-and-therapy-prognosis-in-lung-cancer-patients
#1
Leonel Armas-López, Patricia Piña-Sánchez, Oscar Arrieta, Enrique Guzman de Alba, Blanca Ortiz-Quintero, Patricio Santillán-Doherty, David C Christiani, Joaquín Zúñiga, Federico Ávila-Moreno
Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated. Here, an epigenomic strategy was implemented to identify novel MEOX2 gene promoter transcription targets and propose a new molecular mechanism underlying lung cancer drug resistance and poor clinical prognosis...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28534516/transcriptional-and-posttranscriptional-regulation-of-hoxa13-by-lncrna-hottip-facilitates-tumorigenesis-and-metastasis-in-esophageal-squamous-carcinoma-cells
#2
C Lin, Y Wang, Y Wang, S Zhang, L Yu, C Guo, H Xu
The long non-coding RNA, HOTTIP, has an important role in tumorigenesis. It is known that HOTTIP regulates HOX gene family; however, its regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remains elusive. In this study, we investigated the role of HOTTIP in ESCC and observed that HOTTIP/HOXA13 was upregulated in ESCC and promoted cell proliferation and metastasis in vivo and in vitro. Interestingly, harboring a miR-30b-binding site, HOTTIP as a molecular sponge mainly regulated miR-30b level in the nucleus and modulated the repression of HOXA13 mediated by miR-30b in the cytoplasm, resulting in the positive HOTTIP/HOXA13 correlation...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28529621/hoxa5-and-p53-cooperate-to-suppress-lung-cancer-cell-invasion-and-serve-as-good-prognostic-factors-in-non-small-cell-lung-cancer
#3
Chi-Jen Chang, Yen-Lin Chen, Chia-Hung Hsieh, Ya-Jung Liu, Sung-Liang Yu, Jeremy J W Chen, Chi-Chung Wang
Lung cancer is the leading cause of cancer mortality worldwide and tumor metastasis is the major cause of cancer-related death. Our previous study suggested that Homeobox A5 (HOXA5) could inhibit lung cancer cell invasion via regulating cytoskeletal remodeling and involved in tumor metastasis. Recently, consensus HOX binding sites was found in the p53 gene promoter region. However, whether the HOXA5 could cooperate with p53 and contribute the inhibition of lung cancer cell invasion is still unclear. The aim of the current study is to elucidate the correlation of HOXA5 and p53 in tumor invasion and its prognostic influence in lung cancer patient specimens...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28515451/hoxa7-hoxa9-and-hoxa10-are-differentially-expressed-in-clival-and-sacral-chordomas
#4
Daniela Jäger, Thomas F E Barth, Silke Brüderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, André Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss, Christian R Wirtz, Peter Möller, Kevin Mellert
Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the newly established clivus chordoma cell line, U-CH14, with nine chordoma cell lines originating from sacral primaries by morphology, on genomic and expression levels and with patient samples from our chordoma tissue bank. Clinically, chordomas of the clivus were generally smaller in size at presentation and patients with sacral chordomas had more metastases and more often recurrent disease...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514754/a-hydrophobic-residue-in-the-tale-homeodomain-of-pbx1-promotes-epithelial-to-mesenchymal-transition-of-gastric-carcinoma
#5
Changyu He, Zhenqiang Wang, Li Zhang, Liyun Yang, Jianfang Li, Xuehua Chen, Jun Zhang, Qing Chang, Yingyan Yu, Bingya Liu, Zhenggang Zhu
Pre-B-cell leukemia homeobox 1 (PBX1) was originally identified as a proto-oncogene in human leukemia. Although this protein has been shown to contribute to cellular development and tumorigenesis, the role of PBX1 in gastric carcinoma (GC) remains unclear. In this study, we observed increased expression of PBX1 in GC tissues compared with adjacent normal tissues. This increase in PBX1 expression levels negatively correlated with HOXB9 mRNA expression and was also associated with malignancy and metastasis. PBX1 promoted proliferation and metastasis of GC cells both in vitro and in vivo...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514452/isotopic-evidence-of-multiple-controls-on-atmospheric-oxidants-over-climate-transitions
#6
Lei Geng, Lee T Murray, Loretta J Mickley, Pu Lin, Qiang Fu, Andrew J Schauer, Becky Alexander
The abundance of tropospheric oxidants, such as ozone (O3) and hydroxyl (OH) and peroxy radicals (HO2 + RO2), determines the lifetimes of reduced trace gases such as methane and the production of particulate matter important for climate and human health. The response of tropospheric oxidants to climate change is poorly constrained owing to large uncertainties in the degree to which processes that influence oxidants may change with climate and owing to a lack of palaeo-records with which to constrain levels of atmospheric oxidants during past climate transitions...
May 17, 2017: Nature
https://www.readbyqxmd.com/read/28501885/euforea-rhinology-research-forum-2016-report-of-the-brainstorming-sessions-on-needs-and-priorities-in-rhinitis-and-rhinosinusitis
#7
P W Hellings, C A Akdis, C Bachert, J Bousquet, B Pugin, G Adriaensen, R Advani, I Agache, C Anjo, R Anmolsingh, E Annoni, T Bieber, A Bizaki, I Braverman, I Callebaut, J A Castillo Vizuete, T Chalermwatanachai, R Chmielewski, C Cingi, L Cools, C Coppije, M E Cornet, I De Boeck, E De Corso, G De Greve, M Doulaptsi, R Edmiston, S Erskine, E Gevaert, P Gevaert, K Golebski, C Hopkins, V Hox, C Jaeggi, G Joos, S Khwaja, A Kjeldsen, L Klimek, M Koennecke, I Kortekaas Krohn, O Krysko, B N Kumar, C Langdon, B Lange, G Lekakis, P Levie, E Lourijsen, V J Lund, K Martens, R Mösges, J Mullol, T D Nyembue, S Palkonen, C Philpott, J Pimentel, A Poirrier, A C Pratas, E Prokopakis, L Pujols, P Rombaux, C Schmidt-Weber, C Segboer, I Spacova, J Staikuniene, B Steelant, E A Steinsvik, A Teufelberger, L Van Gerven, K Van Gool, R Verbrugge, B Verhaeghe, P Virkkula, S Vlaminck, E Vries-Uss, M Wagenmann, T Zuberbier, S F Seys, W J Fokkens
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis...
May 14, 2017: Rhinology
https://www.readbyqxmd.com/read/28487406/set1a-compass-and-shadow-enhancers-in-the-regulation-of-homeotic-gene-expression
#8
Kaixiang Cao, Clayton K Collings, Stacy A Marshall, Marc A Morgan, Emily J Rendleman, Lu Wang, Christie C Sze, Tianjiao Sun, Elizabeth T Bartom, Ali Shilatifard
The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression is associated with human cancer. In the developing embryo, Hox genes are activated sequentially in time and space according to their genomic position within Hox gene clusters. Accumulating evidence implicates both enhancer elements and noncoding RNAs in controlling this spatiotemporal expression of Hox genes, but disentangling their relative contributions is challenging...
May 9, 2017: Genes & Development
https://www.readbyqxmd.com/read/28484613/homeotic-shift-at-the-dawn-of-the-turtle-evolution
#9
Tomasz Szczygielski
All derived turtles are characterized by one of the strongest reductions of the dorsal elements among Amniota, and have only 10 dorsal and eight cervical vertebrae. I demonstrate that the Late Triassic turtles, which represent successive stages of the shell evolution, indicate that the shift of the boundary between the cervical and dorsal sections of the vertebral column occurred over the course of several million years after the formation of complete carapace. The more generalized reptilian formula of at most seven cervicals and at least 11 dorsals is thus plesiomorphic for Testudinata...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28484075/twist1-wdr5-hottip-regulates-hoxa9-chromatin-to-facilitate-prostate-cancer%C3%A2-metastasis
#10
Reem Malek, Rajendra P Gajula, Russell D Williams, Belinda Nghiem, Brian W Simons, Katriana Nugent, Hailun Wang, Kekoa Taparra, Ghali Lemtiri-Chlieh, Arum R Yoon, Lawrence True, Steven S An, Theodore L DeWeese, Ashley E Ross, Edward M Schaeffer, Kenneth J Pienta, Paula J Hurley, Colm Morrissey, Phuoc T Tran
TWIST1 is a transcription factor critical for development which can promote prostate cancer metastasis. During embryonic development, TWIST1 and HOXA9 are co-expressed in mouse prostate and then silenced post-natally. Here we report that TWIST1 and HOXA9 co-expression are re-activated in mouse and human primary prostate tumors and are further enriched in human metastases, correlating with survival. TWIST1 formed a complex with WDR5 and the lncRNA Hottip/HOTTIP, members of the MLL/COMPASS-like H3K4 methylases, which regulate chromatin in the Hox/HOX cluster during development...
May 8, 2017: Cancer Research
https://www.readbyqxmd.com/read/28476883/the-long-non-coding-rna-hotair-enhances-pancreatic-cancer-resistance-to-tnf-related-apoptosis-inducing-ligand
#11
Shan-Zhong Yang, Fei Xu, Tong Zhou, Xinyang Zhao, Jay M McDonald, Yabing Chen
Pancreatic cancer is a malignant neoplasm with a high mortality rate. Therapeutic agents that activate TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis have shown promising efficacy, but many pancreatic cancers are resistant to TRAIL therapy. Epigenetic regulation plays important roles in tumor pathogenesis and resistance, and a recent study indicated that the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is overexpressed in pancreatic cancer. However, the role of HOTAIR in pancreatic cancer resistance to anticancer agents is unknown...
May 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28474799/non-allergic-rhinitis-position-paper-of-the-european-academy-of-allergology-and-clinical-immunology
#12
P W Hellings, L Klimek, C Cingi, I Agache, C Akdis, C Bachert, J Bousquet, P Demoly, P Gevaert, V Hox, C Hupin, L Kalogjera, F Manole, R Mösges, J Mullol, N B Muluk, A Muraro, N Papadopoulos, R Pawankar, C Rondon, M Rundenko, S F Seys, E Toskala, L Van Gerven, L Zhang, N Zhang, W J Fokkens
This EAACI position paper aims at providing a state-of-the-art overview on non-allergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as non-allergic non-infectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of minimal 2 nasal symptoms like nasal obstruction, rhinorrhoea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28470721/hox11-function-is-required-for-region-specific-fracture-repair
#13
Danielle R Rux, Jane Y Song, Kyriel M Pineault, Gurjit S Mandair, Ilea T Swinehart, Aleesa J Schlientz, Kayla N Garthus, Steve A Goldstein, Ken M Kozloff, Deneen M Wellik
The processes that govern fracture repair rely on many mechanisms that recapitulate embryonic skeletal development. Hox genes are transcription factors that perform critical patterning functions in regional domains along the axial and limb skeleton during development. Much less is known about roles for these genes in the adult skeleton. We recently reported that Hox11 genes, which function in zeugopod development (radius/ulna and tibia/fibula), are also expressed in the adult zeugopod skeleton exclusively in PDGFRα + /CD51 + /LepR+ mesenchymal stem/stromal cells (MSCs)...
May 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28468905/pervasive-behavioural-effects-of-microrna-regulation-in-drosophila
#14
Joao Picao-Osorio, Ines Lago-Baldaia, Pedro Patraquim, Claudio R Alonso
The effects of microRNA (miRNA) regulation on the genetic programs underlying behaviour remain largely unexplored. Despite this, recent work in Drosophila shows that mutation of a single miRNA locus (miR-iab4/iab8) affects the capacity of the larva to correct its orientation if turned upside-down (self-righting, SR) suggesting that other miRNAs might also be involved in behavioural control. Here we explore this possibility studying early larval SR behaviour in a collection of eighty-one Drosophila miRNA mutants covering almost the entire miRNA complement of the late embryo...
May 3, 2017: Genetics
https://www.readbyqxmd.com/read/28467636/an-exercise-in-brain-genoarchitectonics-analysis-of-azin2-lacz-expressing-neuronal-populations-in-the-mouse-hindbrain
#15
Margaret Martinez-de-la-Torre, Ana Lambertos, Rafael Peñafiel, Luis Puelles
We examined in detail the distribution of AZIN2 (antizyme inhibitor 2) expression in the adult mouse hindbrain and neighboring spinal cord. AZIN2, similar to previously known AZIN1, is a recently-discovered, a functional paralog of ornithine decarboxylase (ODC). Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. AZIN2 is strongly, but heterogeneously, expressed in the brain...
May 3, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28465690/mesenchymal-stem-cells-promoted-lung-wound-repair-through-hox-a9-during-endotoxemia-induced-acute-lung-injury
#16
Xi Xin, Liu Yan, Zhu Guangfa, Huang Yan, Li Keng, Wu Chunting
Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation is recognized as an effective way to repair injured lung tissues. The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism. Methods. MSCs carrying GFP were administrated via trachea into wild-type SD rats 4 hours later after LPS administration. The lung histological pathology and the distribution of MSCs were determined by HE staining and fluorescence microscopy, respectively...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28464221/overexpression-of-hoxa4-and-hoxa9-genes-promotes-self-renewal-and-contributes-to-colon-cancer-stem-cell-overpopulation
#17
Seema Bhatlekar, Vignesh Viswanathan, Jeremy Z Fields, Bruce M Boman
Because HOX genes encode master regulatory transcription factors that regulate stem cells (SCs) during development and aberrant expression of HOX genes occurs in various cancers, our goal was to determine if dysregulation of HOX genes is involved in the SC origin of colorectal cancer (CRC). We previously reported that HOXA4 and HOXD10 are expressed in the colonic SC niche and are overexpressed in CRC. HOX gene expression was studied in SCs from human colon tissue and CRC cells (CSCs) using qPCR and immunostaining...
May 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28462489/role-of-maml1-and-meis1-in-esophageal-squamous-cell-carcinoma-depth-of-invasion
#18
Mohammad Reza Abbaszadegan, Meysam Moghbeli
Homeobox (HOX) transcription factors and NOTCH signaling pathway are critical regulators of stem cell functions, cell fate in development and homeostasis of gastrointestinal tissues. In the present study, we analyzed cross talk between NOTCH pathway and HOX genes through assessment of probable correlation betweenMAML1 and MEIS1 as the main transcription factor of NOTCH pathway and enhancer of HOX transcriptional machinery, respectively in esophageal squamous cell carcinoma (ESCC) patients. Fifty one ESCC cases were enrolled to assess the levels of Meis1 and Maml1 mRNA expression using real-time polymerase chain reaction (PCR)...
May 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28457970/hoxd8-exerts-a-tumor-suppressing-role-in-colorectal-cancer-as-an-apoptotic-inducer
#19
Mohammed A Mansour, Takeshi Senga
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC) in a context-dependent manner. In CRC, HOXD8 is downregulated in cancer tissues and metastatic foci as compared to normal tissues. Whether HOXD8 acts as a tumor suppressor of malignant progression and metastasis is still unclear. Also, the underlying mechanism of its function including the downstream targets is totally unknown...
April 27, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28456906/the-epigenomic-landscape-in-osteoarthritis
#20
REVIEW
Tommie C Simon, Matlock A Jeffries
PURPOSE OF REVIEW: Epigenomics has emerged as a key player in our rapidly evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations, particularly DNA methylation, in OA pathogenesis; however, recent technological advances have resulted in numerous epigenome-wide studies examining in detail epigenetic modifications in OA. The purpose of this article is to introduce basic concepts in epigenetics and their recent applications to the study of osteoarthritis development and progression...
June 2017: Current Rheumatology Reports
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