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https://www.readbyqxmd.com/read/29147778/genome-wide-investigation-of-transcription-factors-provides-insights-into-transcriptional-regulation-in-plutella-xylostella
#1
Qian Zhao, Dongna Ma, Yuping Huang, Weiyi He, Yiying Li, Liette Vasseur, Minsheng You
Transcription factors (TFs), which play a vital role in regulating gene expression, are prevalent in all organisms and characterization of them may provide important clues for understanding regulation in vivo. The present study reports a genome-wide investigation of TFs in the diamondback moth, Plutella xylostella (L.), a worldwide pest of crucifers. A total of 940 TFs distributed among 133 families were identified. Phylogenetic analysis of insect species showed that some of these families were found to have expanded during the evolution of P...
November 16, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29141248/association-of-functional-genetic-variants-of-hotair-with-hepatocellular-carcinoma-hcc-susceptibility-in-a-chinese-population
#2
Hao Li, Xian-Mei Tang, Yangchen Liu, Weizhen Li, Qiaoyun Chen, Yan Pan
BACKGROUND/AIMS: The HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), plays an important role in the pathogenesis and progression of multiple tumors. The aim of the present study was to evaluate whether common single nucleotide polymorphisms (SNPs) in HOTAIR are related to hepatocellular carcinoma (HCC) susceptibility in a Chinese population. METHODS: We genotyped three SNPs of HOTAIR in a hepatocellular carcinoma (HCC) case-control study, including 482 cases and 520 control subjects...
November 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29137688/the-long-noncoding-rna-hotair-promotes-colorectal-cancer-progression-by-sponging-mir-197
#3
Xinyang Lu, Zhiqiang Liu, Xiaofei Ning, Lunhua Huang, Biao Jiang
The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well-known, evidence suggests that microRNA-197 (miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in the progression of colorectal cancer were detected in vitro and in vivo. We found that HOTAIR expression was significantly increased in colorectal cancer cells and tissues...
November 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/29137433/upregulation-of-homeobox-gene-is-correlated-with-poor-survival-outcomes-in-cervical-cancer
#4
Kyung Jin Eoh, Hee Jung Kim, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
HOX family members encode transcription factors crucial for embryogenesis and may be associated with carcinogenesis. Here, we evaluated the expression of 39 HOX genes in cervical cancer by using clinicopathological information and gene expression data of 308 patients from The Cancer Genome Atlas (TCGA) database. Correlations between mRNA expression of HOX family members and clinicopathological variables were explored. Seventy-three (23.7%) patients died during the follow-up period (median, 22.0 months). Overall mortality was significantly associated with advanced FIGO stage, lymph node metastasis, lymphovascular invasion, and increased HOXA1, HOXA5, HOXA6, and HOXC11 mRNA expression...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29118272/beyond-cancer-genes-colorectal-cancer-as-robust-intrinsic-states-formed-by-molecular-interactions
#5
Ruoshi Yuan, Suzhan Zhang, Jiekai Yu, Yanqin Huang, Demin Lu, Runtan Cheng, Sui Huang, Ping Ao, Shu Zheng, Leroy Hood, Xiaomei Zhu
Colorectal cancer (CRC) has complex pathological features that defy the linear-additive reasoning prevailing in current biomedicine studies. In pursuing a mechanistic understanding behind such complexity, we constructed a core molecular-cellular interaction network underlying CRC and investigated its nonlinear dynamical properties. The hypothesis and modelling method has been developed previously and tested in various cancer studies. The network dynamics reveal a landscape of several attractive basins corresponding to both normal intestinal phenotype and robust tumour subtypes, identified by their different molecular signatures...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29115524/high-expression-of-long-non%C3%A2-coding-hotair-correlated-with-hepatocarcinogenesis-and-metastasis
#6
Da-Ni Zhong, Yi-Huan Luo, Wei-Jia Mo, Xin Zhang, Zhong Tan, Na Zhao, Si-Min Pang, Gang Chen, Min-Hua Rong, Wei Tang
HOX transcript antisense RNA (HOTAIR), a newly discovered long noncoding RNA (lncRNA), has been reported to be a poor prognostic marker in many types of cancers. The current study attempted to investigate the biological roles and clinicopathlogical implications of HOTAIR in hepatocellular carcinoma (HCC), as well as understand the molecular mechanisms of HOTAIR in HCC progression. HOTAIR expression in 95 HCC patients with paired HCC tissues and adjacent non‑cancer tissues were investigated using quantitative reverse transcription‑polymerase chain reaction...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105358/formation-of-adult-organs-through-metamorphosis-in-ascidians
#7
REVIEW
Yasunori Sasakura, Akiko Hozumi
The representative characteristic of ascidians is their vertebrate-like, tadpole shape at the larval stage. Ascidians lose the tadpole shape through metamorphosis to become adults with a nonmotile, sessile body and a shape generally considered distinct from that of vertebrates. Solitary ascidians including Ciona species are extensively studied to understand the developmental mechanisms of ascidians, and to compare these mechanisms with their counterparts in vertebrates. In these ascidian species, the digestive and circulatory systems are not well developed in the larval trunk and the larvae do not take food...
November 3, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29104474/association-of-surfactant-protein-with-expression-of-hoxa5-and-hoxb5-in-rabbit-fetal-lung
#8
Sung-Hoon Chung, Chong-Woo Bae
Hox genes regulate organ formation and identity of the embryo, and expressed in specific temporo-spatial patterns in the developing embryo. We compared the expression levels of the Hoxa5, Hoxb5, surfactant protein (SP)-A, and SP-B genes in immature and mature rabbit fetal lung tissues, and to uncover roles for Hoxa5, Hoxb5, SP-A, and SP-B. Cesarean sections were performed after rabbits were divided into two groups of 30-31 days of gestation (term group, n = 24) and 26-27 days of gestation (preterm group, n = 24)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29094201/a-review-of-genetic-factors-contributing-to-the-etiopathogenesis-of-anorectal-malformations
#9
REVIEW
Kashish Khanna, Shilpa Sharma, Noel Pabalan, Neetu Singh, D K Gupta
BACKGROUND: Anorectal malformation (ARM) is a common congenital anomaly with a wide clinical spectrum. Recently, many genetic and molecular studies have been conducted worldwide highlighting the contribution of genetic factors in its etiology. We summarize the current literature on such genetic factors. MATERIALS AND METHODS: Literature search was done using different combinations of terms related to genetics in anorectal malformations. From 2012 to June 2017, articles published in the English literature and studies conducted on human population were included...
November 1, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29083854/applications-of-photogating-and-time-resolved-spectroscopy-to-mechanistic-studies-of-hydrogenases
#10
Brandon L Greene, Gregory E Vansuch, Bryant C Chica, Michael W W Adams, R Brian Dyer
Rapid and facile redox chemistry is exemplified in nature by the oxidoreductases, the class of enzymes that catalyze electron transfer (ET) from a donor to an acceptor. The key role of oxidoreductases in metabolism and biosynthesis has imposed evolutionary pressure to enhance enzyme efficiency, pushing some toward the diffusion limit. Understanding the detailed molecular mechanisms of these highly optimized enzymes would provide an important foundation for the rational design of catalysts for multielectron chemistry, including fuel production...
October 30, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29080815/knockdown-of-long-non-coding-rna-hotair-inhibits-cisplatin-resistance-of-gastric-cancer-cells-through-inhibiting-the-pi3k-akt-and-wnt-%C3%AE-catenin-signaling-pathways-by-up-regulating-mir-34a
#11
Chuanyao Cheng, Yaguang Qin, Qiongjie Zhi, Jianjun Wang, Changjiang Qin
HOX transcript antisense RNA (HOTAIR), a well-known long non-coding RNA (lncRNA), has been reported to be related to cisplatin (DDP) resistance in gastric cancers. However, the molecular mechanism of HOTAIR in DDP resistance of gastric cancer (GC) remains largely undefined. The aim of this study was to investigate the role and underlying mechanism of HOTAIR in regulating cisplatin resistance of GC. The results showed that HOTAIR was over-expressed in GC tissues and GC cell lines, while miR-34a was low-expressed...
October 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29079719/integrated-proteomic-and-transcriptomic-analysis-revealslong-noncoding-rna-hotair-promotes-hepatocellular-carcinoma-cell-proliferation-by-regulating-opioid-growth-factor-receptor-ogfr
#12
Ying Wu, Qian Xiong, Siting Li, Xue Yang, Feng Ge
Long non-coding RNA HOX transcript antisense RNA (HOTAIR) is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying HOTAIR functions in HCC are largely unknown. Here, we employed an integrated transcriptomic and quantitative proteomic analysis to systematically explore the regulatory role of HOTAIR in HCC. A total of 673 transcripts and 293 proteins were found to be dysregulated after HOTAIR inhibition. Bioinformatics studies indicated that differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) are involved in many biological processes, especially cancer-related signaling pathways...
October 27, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29073728/hoxa3-promotes-tumor-growth-of-human-colon-cancer-through-activating-egfr-ras-raf-mek-erk-signaling-pathway
#13
Xianxiang Zhang, Guangwei Liu, Lei Ding, Tao Jiang, Shihong Shao, Yuan Gao, Yun Lu
Homeobox A3 (HOXA3), one of HOX transcription factors, regulates gene expression during embryonic development. HOXA3 expression has been reported to be associated with several cancers; however, its role in colon cancer and underlying mechanism are still unclear. The expression of HOXA3 in 232 paired of human colon tumor and adjacent non-tumorous tissues were measured by qPCR. The relationship between HOXA3 expression and clinical outcomes were analyzed by Kaplan-Meier survival curves analysis. Human colon cancer cell lines HT29 and HTC116 were transfected with HOXA3 siRNA or HOXA3 expressing vector, and then cell proliferation and apoptosis were assessed, respectively...
October 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29069846/expression-of-the-long-non-coding-rna-hotair-as-a-prognostic-factor-in-squamous-cell-carcinoma-of-the-head-and-neck-a-systematic-review-and-meta-analysis
#14
Giuseppe Troiano, Vito Carlo Alberto Caponio, Linda Boldrup, Xiaolian Gu, Lorenzo Lo Muzio, Nicola Sgaramella, Lixiao Wang, Karin Nylander
INTRODUCTION: Long noncoding RNAs (lncRNAs) are often dysregulated in cancer tissue and seem to play an important role in neoplastic processes. Recent studies have shown that the HOX transcript antisense intergenic RNA (HOTAIR) may play a role as a marker of prognosis in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to perform a meta-analysis of studies focused on the prognostic role of HOTAIR in SCCHN. RESULTS: At the end of the selection process, four studies were considered eligible for inclusion in the meta-analysis, comprising a total of 271 patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069594/columnar-intrinsic-cues-shape-premotor-input-specificity-in-locomotor-circuits
#15
Myungin Baek, Chiara Pivetta, Jeh-Ping Liu, Silvia Arber, Jeremy S Dasen
Control of movement relies on the ability of circuits within the spinal cord to establish connections with specific subtypes of motor neuron (MN). Although the pattern of output from locomotor networks can be influenced by MN position and identity, whether MNs exert an instructive role in shaping synaptic specificity within the spinal cord is unclear. We show that Hox transcription-factor-dependent programs in MNs are essential in establishing the central pattern of connectivity within the ventral spinal cord...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29067125/long-non-coding-rna-hox-transcript-antisense-rna-promotes-expression-of-14-3-3%C3%AF-in-non-small-cell-lung-cancer
#16
Ranran Wang, Bin Yan, Zheng Li, Yiqun Jiang, Chao Mao, Xiang Wang, Xinmin Zhou
Evidence suggests that both 14-3-3σ and long non-coding RNA HOX transcript antisense RNA (HOTAIR) are involved in the tumorigenesis and progression of lung cancer. In the present study, the potential association between 14-3-3σ and HOTAIR in non-small cell lung cancer (NSCLC) was investigated. In tissue samples collected from 54 patients with NSCLC, expression of HOTAIR and 14-3-3σ was analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). After stable ectopic expression of HOTAIR and stable HOTAIR knockdown in PC9 cancer cells, the effect of HOTAIR on levels of mRNA and protein 14-3-3σ expression levels were detected using RT-qPCR and western blotting, respectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29067121/effect-of-testosterone-and-hypoxia-on-the-expansion-of-umbilical-cord-blood-cd34-cells-in-vitro
#17
Liping Zhou, Xiaowei Zhang, Panpan Zhou, Xue Li, Xuejing Xu, Qing Shi, Dong Li, Xiuli Ju
Successfully expanding hematopoietic stem cells (HSCs) is advantageous for clinical HSC transplantation. The present study investigated the influence of testosterone on the proliferation, antigen phenotype and expression of hematopoiesis-related genes in umbilical cord blood-derived cluster of differentiation (CD)34(+) cells under normoxic or hypoxia conditions. Cord blood (CB) CD34(+) cells were separated using magnetic activated cell sorting. A cytokine cocktail and feeder cells were used to stimulate the expansion of CD34(+) cells under normoxic (20% O2) and hypoxic (1% O2) conditions for 7 days and testosterone was added accordingly...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29061638/motor-neurons-with-limb-innervating-character-in-the-cervical-spinal-cord-are-sculpted-by-apoptosis-based-on-the-hox-code-in-chick-embryo
#18
Katsuki Mukaigasa, Chie Sakuma, Tomoaki Okada, Shunsaku Homma, Takako Shimada, Keiji Nishiyama, Noboru Sato, Hiroyuki Yaginuma
In the developing chick embryo, a certain population of motor neurons (MNs) in the non-limb-innervating cervical spinal cord undergoes apoptosis between embryonic days 4 and 5. However, the characteristics of these apoptotic MNs remain undefined. Here, by examining the spatiotemporal profiles of apoptosis and MN subtype marker expression in normal or apoptosis-inhibited chick embryos, we found that this apoptotic population is distinguishable by Foxp1 expression. When apoptosis was inhibited, the survived Foxp1+ MNs showed characteristics of lateral motor column (LMC) neurons, which are of a limb-innervating subtype, suggesting that cervical Foxp1(+) MNs are the rostral continuation of LMC...
October 23, 2017: Development
https://www.readbyqxmd.com/read/29050303/dysregulated-expression-of-homeobox-family-genes-may-influence-survival-outcomes-of-patients-with-epithelial-ovarian-cancer-analysis-of-data-from-the-cancer-genome-atlas
#19
Kyung Jin Eoh, Hee Jung Kim, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
Homeobox (HOX) family genes encode key transcription factors for embryogenesis and may be correlated with carcinogenesis. The aim of this study was to elucidate whether aberrant expression of HOX genes influences outcomes in epithelial ovarian cancer (EOC). Gene expression data and clinicopathologic information from 630 patients with EOC were downloaded from The Cancer Genome Atlas database. We explored correlations between expression levels of HOX gene family members and clinicopathological variables. Higher expression of HOXA1, A4, A5, A7, A10, A11, B13, C13, D1, and D3 was associated with advanced FIGO stage...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046533/anatomical-integration-of-the-sacral-hindlimb-unit-coordinated-by-gdf11-underlies-variation-in-hindlimb-positioning-in-tetrapods
#20
Yoshiyuki Matsubara, Tatsuya Hirasawa, Shiro Egawa, Ayumi Hattori, Takaya Suganuma, Yuhei Kohara, Tatsuya Nagai, Koji Tamura, Shigeru Kuratani, Atsushi Kuroiwa, Takayuki Suzuki
Elucidating how body parts from different primordia are integrated during development is essential for understanding the nature of morphological evolution. In tetrapod evolution, while the position of the hindlimb has diversified along with the vertebral formula, the mechanism responsible for this coordination has not been well understood. However, this synchronization suggests the presence of an evolutionarily conserved developmental mechanism that coordinates the positioning of the hindlimb skeleton derived from the lateral plate mesoderm with that of the sacral vertebrae derived from the somites...
September 2017: Nature ecology & evolution
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