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Low t3 syndrome

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https://www.readbyqxmd.com/read/29763907/beyond-irritable-bowel-syndrome-the-efficacy-of-the-low-fodmap-diet-for-improving-symptoms-in-inflammatory-bowel-diseases-and-celiac-disease
#1
Anna Testa, Nicola Imperatore, Antonio Rispo, Matilde Rea, Raffaella Tortora, Olga Maria Nardone, Lucia Lucci, Grazia Accarino, Nicola Caporaso, Fabiana Castiglione
BACKGROUND AND AIM: To evaluate the usefulness of a low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). METHODS: Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria. Each subject was educated to follow a low FODMAP diet after being evaluated by filling out questionnaires that assessed the quality of life (QoL) and symptoms experienced (IBS-SSS and SF-36), and was reevaluated after 1 and 3 months...
May 15, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29652271/prophylactic-preoperative-levosimendan-for-off-pump-coronary-artery-bypass-grafting-in-patients-with-left-ventricular-dysfunction-single-centered-randomized-prospective-study
#2
Pushkar Mahendra Desai, Manjula S Sarkar, Sanjeeta R Umbarkar
Background: Off-pump coronary artery bypass surgery (OPCAB) is often complicated by hemodynamic instability, especially in patients with prior left ventricular (LV) dysfunction and appropriate choice of inotrope plays a vital role in perioperative management of these patients. Aim and Objective: To study hemodynamic effects and immediate outcome of prophylactic infusion of levosimendan in patients with the LV dysfunction undergoing OPCAB surgery and whether this strategy helps in successful conduct of OPCAB surgery...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29627642/a-prognostic-role-for-low-tri-iodothyronine-syndrome-in-acute-stroke-patients-a-systematic-review-and-meta-analysis
#3
REVIEW
Nayan Lamba, Chunming Liu, Hasan Zaidi, M L D Broekman, Thomas Simjian, Chen Shi, Joanne Doucette, Steven Ren, Timothy R Smith, Rania A Mekary, Adomas Bunevicius
BACKGROUND: Low triiodothyronine (T3) syndrome could be a powerful prognostic factor for acute stroke; yet, a prognostic role for low T3 has not been given enough importance in stroke management. This meta-analysis aimed to evaluate whether low T3 among acute stroke patients could be used as a prognostic biomarker for stroke severity, functional outcome, and mortality. METHODS: Studies that investigated low T3 prognostic roles in acute stroke patients were sought from PubMed/Medline, Embase, and Cochrane databases through 11/23/2016...
March 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29615976/higher-prevalence-of-low-t3-syndrome-in-patients-with-chronic-fatigue-syndrome-a-case-control-study
#4
Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29580665/low-t3-syndrome-improves-risk-prediction-of-in-hospital-cardiovascular-death-in-patients-with-acute-myocardial-infarction
#5
Wen Su, Xue-Qiao Zhao, Man Wang, Hui Chen, Hong-Wei Li
BACKGROUND: Low triiodothyronine (T3) syndrome (LT3S) is frequently seen in patients with acute myocardial infarction (AMI). We examined the association between LT3S and severity of myocardial injury and determined whether LT3S adds predictive value over thrombolysis in myocardial infarction (TIMI) risk score for in-hospital cardiovascular (CV) death. METHODS: Of 2459 AMI patients, 529 pairs of euthyroid and LT3S individuals with similar baseline characteristics were identified using 1:1 propensity score matching...
March 23, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29520606/low-peak-jump-power-is-associated-with-elevated-odds-of-dysmobility-syndrome-in-community-dwelling-elderly-individuals-the-korean-urban-rural-elderly-kure-study
#6
Namki Hong, Chang Oh Kim, Yoosik Youm, Hyeon Chang Kim, Yumie Rhee
In a community-dwelling elderly cohort (Korean Urban Rural Elderly), low peak jump power was associated with elevated odds of dysmobility syndrome and its components, independent of age and comorbidities. Jump power measurement improved discrimination of individuals with dysmobility syndrome when added to conventional risk factors. INTRODUCTION: Dysmobility syndrome was proposed to encompass the risks affecting musculoskeletal outcomes. Jump power measurement is a safe, reproducible high-intensity test for physical function in elderly...
March 8, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#7
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia- Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29371771/effect-of-interaction-between-duration-of-alcohol-consumption-and-alcohol-dependence-on-thyroid-function-test-cross-sectional-observational-study
#8
J B Honnamurthy, A R Shivashankara, S S Avinash, P John Mathai, M Malathi
Dependence on alcohol, nicotine and duration of alcohol consumption are known to alter thyroid function tests. This study was conducted to assess the effect of interaction between the duration of alcohol consumption and alcohol dependence on TFT. The subjects consisted of 38 male patients with alcohol dependent syndrome co morbid with nicotine dependent syndrome, 33 male patients with alcohol dependent syndrome and 30 male normal healthy volunteers. Liver function tests, haematological parameters and thyroid function tests were assayed...
January 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29279270/prevalence-of-thyroid-disorders-in-north-indian-type-2-diabetic-subjects-a-cross-sectional-study
#9
Maaz Ozair, Saba Noor, Alok Raghav, Sheelu Shafiq Siddiqi, Anjum Mirza Chugtai, Jamal Ahmad
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated. OBJECTIVES: The study aimed at determining the incidence and prevalence of thyroid dysfunction in patients with T2DM in relation to age, sex, metabolic syndrome and other co-morbid conditions...
May 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29277171/post-intensive-care-syndrome-symptoms-and-health-related-quality-of-life-in-family-decision-makers-of-critically-ill-patients
#10
Amy B Petrinec, Bradley R Martin
OBJECTIVE: Family members of critically ill patients can suffer symptoms of post-intensive care syndrome-family (PICS-F), including anxiety, depression, and posttraumatic stress disorder (PTSD) with a diminished quality of life. Our aim was to examine the relationship between coping strategies used by family decision-makers (FDMs) of critically ill patients and the severity of PICS-F symptoms and to examine the relationship between FDM PICS-F symptoms and health-related quality of life (HRQOL)...
December 26, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29234626/consumptive-hypothyroidism-case-report-of-hepatic-hemangioendotheliomas-successfully-treated-with-vincristine-and-systematic-review-of-the-syndrome
#11
Marina Weber Pasa, Rafael Selbach Scheffel, André Borsatto Zanella, Ana Luiza Maia, José Miguel Dora
Objectives: To provide a comprehensive description of consumptive hypothyroidism syndrome (CHS), a severe form of hypothyroidism that occurs due to the high expression levels of thyroid hormone inactivation enzyme type 3 deiodinase (D3) in tumors. Study Design: Case report and systematic review. Results: A 7-month-old girl with a diagnosis of massive hepatic hemangioendotheliomas was treated with high doses of thyroid hormones and tumor-directed chemotherapy with vincristine...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29212251/low-ft3-is-associated-with-diminished-health-related-quality-of-life-in-patients-with-acute-coronary-syndrome-treated-with-drug-eluting-stent-a-longitudinal-observational-study
#12
Chao Xue, Ling Bian, Yu Shui Xie, Zhao Fang Yin, Zuo Jun Xu, Qi Zhi Chen, Hui Li Zhang, Yu Qi Fan, Run Du, Chang Qian Wang
Acute coronary syndrome (ACS) patients with low triiodothyronine (T3) syndrome characterized by low free T3 (fT3) levels with normal thyroxine (T4) and thyroid-stimulating hormone (TSH) have a higher rate of death. The impact of fT3 on Health related quality of life (HRQOL) in patients with ACS is still unknown. 528 ACS patients treated with drug-eluting stent (DES) were included in this prospective, observational study. Patients were classified into low fT3 group (n=126) and normal fT3 group (n=402) according to serum fT3 level...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29171874/serum-paraoxonase-1-activity-is-inversely-related-to-free-thyroxine-in-euthyroid-subjects-the-prevend-cohort-study
#13
Lynnda J N van Tienhoven-Wind, Eke G Gruppen, Richard W James, Stephan J L Bakker, Rijk O B Gans, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with thyroid stimulating hormone (TSH), free T4 , free T3 , lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS)...
January 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29132333/oestrogen-receptor-beta-isoform-expression-in-sporadic-colorectal-cancer-familial-adenomatous-polyposis-and-progressive-stages-of-colorectal-cancer
#14
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. METHODS: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29118715/differential-regulation-of-thyroid-hormone-metabolism-target-genes-during-non-thyoidal-illness-syndrome-triggered-by-fasting-or-sepsis-in-adult-mice
#15
Klaus N Fontes, Adriana Cabanelas, Flavia F Bloise, Cherley Borba Vieira de Andrade, Luana L Souza, Marianna Wilieman, Isis H Trevenzoli, Lais C Agra, Johnatas D Silva, Christianne Bandeira-Melo, Pedro L Silva, Patricia R M Rocco, Tania M Ortiga-Carvalho
Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the tissue level. Moreover, even though it has been considered the same syndrome, we hypothesized that fasting and sepsis induce a distinct set of changes in thyroid hormone metabolism. Herein, we aimed to evaluate the central and peripheral expression of genes involved in the transport (MCT8/ Slc16a2 and MCT10/ Slc16a10 ), metabolism ( Dio1, Dio2 , and Dio3 ) and action ( Thra and Thrb ) of TH during NTIS induced by fasting or sepsis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29102271/prevalence-of-malnutrition-inflammation-complex-syndrome-and-its-correlation-with-thyroid-hormones-in-chronic-haemodialysis-patients
#16
Venice Chávez Valencia, Oliva Mejía Rodríguez, Martha Eva Viveros Sandoval, Juan Abraham Bermúdez, Sergio Gutiérrez Castellanos, Citlalli Orizaga de la Cruz, Martha Alicia Roa Córdova
INTRODUCTION: Low levels of thyroid hormones, total triiodothyronine (T3) and free triiodothyronine (FT3) in haemodialysis patients is a marker of malnutrition and inflammation and are predictors of mortality. The aim of this study was to determine the prevalence of malnutrition-inflammation complex syndrome in haemodialysis and its relationship with the thyroid hormones thyrotropin, T3, FT3 and free thyroxine (FT4), as well as to evaluate the prevalence of low FT3 syndrome and its correlation with nutritional and inflammatory markers...
January 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29077876/t3-and-glucose-coordinately-stimulate-chrebp-mediated-ucp1-expression-in-brown-adipocytes-from-male-mice
#17
COMPARATIVE STUDY
Liora S Katz, Shiliyang Xu, Kai Ge, Donald K Scott, Marvin C Gershengorn
Increasing brown adipose tissue (BAT) activity is regarded as a potential treatment of obese, hyperglycemic patients with metabolic syndrome. Triiodothyronine (T3) is known to stimulate BAT activity by increasing mitochondrial uncoupling protein 1 (Ucp1) gene transcription, leading to increased thermogenesis and decreased body weight. Here we report our studies on the effects of T3 and glucose in two mouse models and in mouse immortalized brown preadipocytes in culture. We identified carbohydrate response element binding protein (ChREBP) as a T3 target gene in BAT by RNA sequencing and studied its effects in brown adipocytes...
January 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29035196/thyroid-function-in-patients-on-continuous-ambulatory-peritoneal-dialysis-in-comparison-with-chronic-kidney-disease
#18
Toru Sanai, Akinori Nagashima, Ken Okamura, Shuichi Rikitake, Makoto Fukuda, Koji Onozawa, Mai Sanematsu, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda
BACKGROUND/METHODS: Thyroid function was evaluated in 14 Japanese patients on continuous ambulatory peritoneal dialysis (CAPD) with end-stage renal disease compared with 11 chronic kidney disease (CKD) stage 1+2 patients (glomerular filtration rate ≥ 60 mL/min/1.73m<sup>2</sup>). RESULTS: The serum free triiodothyronine (fT<sub>3</sub>) (2.2 ± 0.3 pg/mL, p < 0.05) levels were lower, and the rate of low triiodothyronine (T<sub>3</sub>) syndrome was higher (4 of 13 cases, 30...
March 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/28967725/testicular-and-thyroid-function-as-survival-predictors-in-the-elderly-patient-candidate-to-surgery
#19
Antonio Aversa, Andrea Fabbri
The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28929663/-effect-of-aca%C3%A3-euterpe-oleracea-on-biological-expression-characteristics-of-deficiency-heat-and-deficiency-cold-rats
#20
Lin-Yuan Wang, Jian-Jun Zhang, Chun Wang, Ying-Li Zhu, Zi-Chen Wang, Cheng He, Yan Qu, Sha Wang
To study the effects of Acaí on biological expression characteristics in rats with deficiency-heat and deficiency-cold syndromes, SD rats were divided into blank group, deficiency-heat model group, deficiency-heat+Phellodendri Chinensis Cortex group, deficiency-heat+Acaí high dose and low dose groups, deficiency-cold model group, deficiency-cold+Cinnamomi Cortex group, deficiency-cold+Acaí high dose and low dose groups. The rats were treated with intramuscular injection of hydrocortisone (20 mg•kg⁻¹) or dexamethasone sodium phosphate (0...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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