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Anti tuberculosis agents

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https://www.readbyqxmd.com/read/28318613/latent-tuberculosis-infection-screening-prior-to-biological-treatment-in-tunisian-patients
#1
Marwa Slouma, Ines Mahmoud, Olfa Saidane, Selma Bouden, Leila Abdelmoula
OBJECTIVES: The screening of latent tuberculosis infection (LTBI) is necessary to prevent infection in patients with chronic inflammatory disease (CID) undergoing biological treatment. We aimed to assess the efficacy of LTBI screening prior to biological treatment in Tunisia, considered as a high-incidence area of active TB disease. METHODS: We conducted a retrospective study over a period of 8 years [2007-2014] including patients with chronic inflammatory rheumatism receiving biologic agents since at least 6 months...
February 24, 2017: Thérapie
https://www.readbyqxmd.com/read/28317798/nontuberculous-mycobacterial-species-and-mycobacterium-tuberculosis-complex-coinfection-in-patients-with-pulmonary-tuberculosis-in-dr-soetomo-hospital-surabaya-indonesia
#2
Ni Made Mertaniasih, Deby Kusumaningrum, Eko Budi Koendhori, Tutik Kusmiati, Desak Nyoman Surya Suameitria Dewi
OBJECTIVE/BACKGROUND: The aim of this study was to analyze the detection of nontuberculous mycobacterial (NTM) species derived from sputum specimens of pulmonary tuberculosis (TB) suspects. Increasing prevalence and incidence of pulmonary infection by NTM species have widely been reported in several countries with geographical variation. MATERIALS AND METHODS: Between January 2014 and September 2015, sputum specimens from chronic pulmonary TB suspect patients were analyzed...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317629/mycobacterium-kansasii-infection-in-a-patient-receiving-biologic-therapy-not-all-reactive-interferon-gamma-release-assays-are-tuberculosis
#3
Nasir Saleem, Raya Saba, Srikanth Maddika, Mitchell Weinstein
Mycobacterium kansasii, a nontuberculous mycobacterium, can lead to lung disease similar to tuberculosis. Immunotherapeutic biologic agents predispose to infections with mycobacteria, including M kansasii. T-cell-mediated interferon gamma release assays like QuantiFERON-TB Gold Test (QFT) are widely used by clinicians for the diagnosis of infections with Mycobacterium tuberculosis; however, QFT may also show positive result with certain nontuberculous mycobacterial infections. We report a case of M kansasii pulmonary infection, with a positive QFT, in an immunocompromised patient receiving prednisone, leflunomide and tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28303436/mutations-in-catalase-peroxidase-katg-from-isoniazid-resistant-mycobacterium-tuberculosis-clinical-isolates-insights-from-molecular-dynamics-simulations
#4
Arethusa Lobo Pimentel, Regiane Bertin de Lima Scodro, Katiany Rizzieri Caleffi-Ferracioli, Vera Lúcia Dias Siqueira, Paula Aline Zanetti Campanerut-Sá, Luciana Dias Ghiraldi Lopes, Aryadne Larissa de Almeida, Rosilene Fressatti Cardoso, Flavio Augusto Vicente Seixas
The current multidrug therapy for tuberculosis (TB) is based on the use of isoniazid (INH) in combination with other antibiotics such as rifampin, ethambutol and pyrazinamide. Literature reports have shown that Mycobacterium tuberculosis, the causative agent of TB, has become resistant to this treatment by means of point mutations in the target enzymes of these drugs, such as catalase-peroxidase (KatG). By means of equilibrium molecular dynamics in the presence of the ligand, this work evaluated ten point mutations described in the enzyme KatG that are related to resistance to INH ...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28297677/recombinant-bcg-expressing-esx-1-of-mycobacterium-marinum-combines-low-virulence-with-cytosolic-immune-signaling-and-improved-tb-protection
#5
Matthias I Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limited protection. A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs phagosomal rupture and cytosolic pattern recognition, key intracellular phenotypes linked to increased immune signaling...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28287416/novel-pharmacological-activity-of-artesunate-and-artemisinin-their-potential-as-anti-tubercular-agents
#6
Won Hyung Choi
Tuberculosis is a major infectious disease that globally causes the highest human mortality. From this aspect, this study was carried out to evaluate novel pharmacological activities/effects of artesunate and artemisinin causing anti-tubercular activity/effects against Mycobacterium tuberculosis (Mtb). The anti-Mtb activities/effects of artesunate and artemisinin were evaluated using different anti-Mtb indicator assays, such as the resazurin microtiter assay, the Mycobacteria Growth Indicator Tube (MGIT) 960 system assay, and the Ogawa slant medium assay, as well as in vivo tests...
March 10, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28281912/naphthofuroquinone-derivatives-show-strong-antimycobacterial-activities-against-drug-resistant-mycobacteria
#7
Woong Sik Jang, Young-Sang Choi, Sukyung Kim, Md Anirban Jyoti, Hoonhee Seo, Juhye Han, Yong-Sik Kim, Jiwon Lyu, Kung-Woo Nam, Byung-Eui Lee, Kee-In Lee, Ho-Yeon Song
Tuberculosis, one of the world's major health problems, has become more serious due to the emergence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB). In this study, we performed three anti-MTB assays to evaluate the anti-mycobacterial activity of naphthofuroquinone derivatives against drug-resistant MTB. Among them, methyl 5-[2-(dimethylamino)ethoxy]-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2',3'-d]furan-6-carboxylate (DFC2) exhibited strong anti-mycobacterial activity against MTB H37Ra, H37Rv and four drug-resistant MTB strains...
March 10, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28267891/design-synthesis-and-in-vitro-anti-tuberculosis-activity-of-benzo-6-7-cyclohepta-1-2-b-pyridine-1-3-4-oxadiazole-derivatives
#8
Yasodakrishna Sajja, Sowmya Vanguru, Hanmanth Reddy Vulupala, Lingaiah Nagarapu, Perumal Yogeswari, Dharmarajan Sriram, Jagadeesh Babu Nanubolu
A new anti-tubercular agents, benzo[6,7]cyclohepta[1,2-b]pyridine -1,3,4- oxadiazole hybrids (6a-o) have been designed and synthesized involving oxidative cyclization of hydrazones by use of di(acetoxy)iodobenzene (DIB) and characterized by IR,(1) H NMR,(13) C NMR, HRMS and further confirmed by X-ray analysis. All the newly synthesized compounds 4a-o evaluated for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC27294). Among the compounds tested, the compounds 4o (MIC: 1...
March 7, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28257847/validation-of-mycobacterium-tuberculosis-dihydroneopterin-aldolase-as-a-molecular-target-for-anti-tuberculosis-drug-development
#9
V C A Falcão, A D Villela, V S Rodrigues-Junior, K Pissinate, P Eichler, A F M Pinto, L A Basso, D S Santos, C V Bizarro
An early step of target validation in antimicrobial drug discovery is to prove that a gene coding for a putative target is essential for pathogen's viability. However, little attention has been paid to demonstrate the causal links between gene essentiality and a particular protein function that will be the focus of a drug discovery effort. This should be considered an important step in target validation since a growing number of proteins are found to exhibit multiple and unrelated tasks. Here, we show that the Mycobacterium tuberculosis (Mtb) folB gene is essential and that this essentiality depends on the dihydroneopterin aldolase/epimerase activities of its protein product, the FolB protein from the folate biosynthesis pathway...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28255643/use-of-etanercept-to-treat-rheumatoid-arthritis-in-an-hiv-positive-patient-a-case-based-review
#10
REVIEW
Shen-Ju Liang, Quan-You Zheng, Yan-Long Yang, Yi Yang, Chong-Yang Liu
Rheumatoid arthritis (RA) is a relatively common autoimmune disease that is associated with progressive disability and systemic complications, with a relatively high socioeconomic burden. The treatment of RA has been revolutionized by the use of biological drugs, such as anti-tumor necrosis factor (TNF) agents. A wide spectrum of RA disease severity has been reported among patients with human immunodeficiency virus (HIV) infection. Yet, only a few cases using anti-TNF therapy have been described in this clinical population...
March 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28254318/detection-of-esat-6-by-a-label-free-miniature-immuno-electrochemical-biosensor-as-a-diagnostic-tool-for-tuberculosis
#11
Mohamed Fethi Diouani, Oussama Ouerghi, Amira Refai, Kamel Belgacem, Chaker Tlili, Dhafer Laouini, Makram Essafi
Tuberculosis is a worldwide disease considered as a major health problem with high morbidity and mortality rates. Poor detection of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis remains a major obstacle to the global control of this disease. Here we report the development of a new test based on the detection of the major virulent factor of Mtb, namely the early secreted antigenic target 6-kDa protein or ESAT-6. A label free electrochemical immunosensor using an anti-ESAT-6 monoclonal antibody as a bio-receptor is described herein...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28254074/development-of-antibacterial-conjugates-using-sulfamethoxazole-with-monocyclic-terpenes-a-systematic-medicinal-chemistry-based-computational-approach
#12
Shasank S Swain, Sudhir K Paidesetty, Rabindra N Padhy
BACKGROUND AND OBJECTIVE: To develop 6 conjugate agents of the moribund antibiotic sulfamethoxazole (SMZ) joined to 6 individual monoterpenes, followed by protocols of medicinal chemistry as potent antibacterials, against multidrug resistant (MDR) human gruesome pathogenic bacteria. METHODS: Antibacterial activities of the proposed conjugates were ascertained by the 'prediction of activity spectra of substances' (PASS) program. Drug-likeness parameters and toxicity profiles of conjugates were standardized with the Lipinski rule of five, using cheminformatic tools, Molsoft, molinspiration, OSIRIS and ProTox...
March 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28249101/azido-pentoses-a-new-tool-to-efficiently-label-mycobacterium-tuberculosis-clinical-isolates
#13
Katharina Kolbe, Leonhard Möckl, Victoria Sohst, Julius Brandenburg, Regina Engel, Sven Malm, Christoph Bräuchle, Otto Holst, Thisbe K Lindhorst, Norbert Reiling
Mycobacterium tuberculosis (Mtb), the main causative agent of tuberculosis (Tb), has a complex cell envelope which forms an efficient barrier to antibiotic stress, contributing to the obstacles of anti-tuberculosis therapy. However, the uniqueness of the Mtb cell wall can be considered an advantage and be utilized to selectively label Mtb bacteria. Here we introduce three azido pentoses, 3 azido arabinose (3AraAz), 3-azido ribose (3RiboAz) and 5-azido arabinofuranose (5AraAz), as new compounds for metabolic labeling of Mtb...
March 1, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28248311/sansanmycin-natural-product-analogues-as-potent-and-selective-anti-mycobacterials-that-inhibit-lipid-i-biosynthesis
#14
Anh T Tran, Emma E Watson, Venugopal Pujari, Trent Conroy, Luke J Dowman, Andrew M Giltrap, Angel Pang, Weng Ruh Wong, Roger G Linington, Sebabrata Mahapatra, Jessica Saunders, Susan A Charman, Nicholas P West, Timothy D H Bugg, Julie Tod, Christopher G Dowson, David I Roper, Dean C Crick, Warwick J Britton, Richard J Payne
Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for more than 40 years. Owing to widespread resistance to these therapies, new drugs are desperately needed to control the TB disease burden. Herein, we describe the rapid synthesis of analogues of the sansanmycin uridylpeptide natural products that represent promising new TB drug leads. The compounds exhibit potent and selective inhibition of Mycobacterium tuberculosis, the etiological agent of TB, both in vitro and intracellularly...
March 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28235402/anti-mycobacteria-potential-and-synergistic-effects-of-combined-crude-extracts-of-selected-medicinal-plants-used-by-bapedi-traditional-healers-to-treat-tuberculosis-related-symptoms-in-limpopo-province-south-africa
#15
Nancy Patience Motlalepula Komape, Victor Patrick Bagla, Prudence Kabongo-Kayoka, Peter Masoko
BACKGROUND: Tuberculosis is an infectious communicable disease and the causative agent of the disease has over the years developed resistance to streamline chemotherapeutic agents with dire consequences and there is a need for development of new and more potent alternatives. METHODS: Constituents of leaves material of Combretum heroroense, Citrus lemon and Apodytes dimidiata were serially extracted using solvents of varying polarity. TLC finger print profile of the different extracts were determined by spraying eluted plates with vanillin sulphuric acid and 2, 2- diphenylpicryl hydrazyl (DPPH) for the presence of antioxidant constituents...
February 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28228760/perturbed-microrna-expression-by-mycobacterium-tuberculosis-promotes-macrophage-polarization-leading-to-pro-survival-foam-cell
#16
Pankaj Kumar Ahluwalia, Rajan Kumar Pandey, Prabodh Kumar Sehajpal, Vijay Kumar Prajapati
Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocytic cells that are central to immunity against MTb. These are highly plastic cells dependent on the milieu and can showcase M1/M2 polarization. M1 macrophages are bactericidal in action, but M2 macrophages are anti-inflammatory in their immune response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28225346/cd4-count-and-risk-of-anti-tuberculosis-drug-associated-cutaneous-reactions-in-hiv-infected-thai-patients
#17
L Boonyagars, P Hirunwiwatkul, C P Hurst
OBJECTIVES: Tuberculosis (TB) is a major cause of morbidity and mortality in human immunodeficiency virus (HIV) infected patients. However, anti-tuberculosis drugs can cause cutaneous adverse drug reactions (CADRs). This study was conducted to evaluate differences in CADR incidence between low and high CD4 cell count in patients with low and high CD4 cell count and to identify other risk factors for CADR in HIV-TB co-infected patients. DESIGN: In a retrospective cohort of adult HIV-TB co-infected patients receiving standard anti-tuberculosis treatment between January 2008 and December 2015 at Vajira Hospital, Bangkok, Thailand, baseline demographic, clinical characteristics and factors associated with CADRs, including CD4 cell count status, were collected...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28222400/antiprotozoal-antimycobacterial-and-anti-inflammatory-evaluation-of-cnidoscolus-chayamansa-mc-vaugh-extract-and-the-isolated-compounds
#18
Mariana Z Pérez-González, Gabriel A Gutiérrez-Rebolledo, Lilián Yépez-Mulia, Irma S Rojas-Tomé, Julieta Luna-Herrera, María A Jiménez-Arellanes
Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant's phytochemical analysis and biological activities (antimycobacterial, antibacterial, antiprotozoal, and anti-inflammatory properties) of the CHCl3:MeOH (1:1) leaves extract and isolated compounds, as well as the acute and sub-acute toxic effects...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28208905/n-acetylcysteine-combined-with-home-based-physical-activity-effect-on-health-related-quality-of-life-in-stable-copd-patients-a-randomised-controlled-trial
#19
Vijay Tukaram Salve, Jitesh S Atram
INTRODUCTION: Quality of life is adversely affected in Chronic Obstructive Pulmonary Disease (COPD), due to irreversible, progressive nature of the disease and limitations of current treatment options available. One of the important aim of treatment of COPD is to improve Quality of Life (QoL). Cigarette smoke contains numerous free radicals and other oxidants. Oxidative stress has been implicated in pathogenesis, progression of disease and exacerbation in COPD. Pulmonary tuberculosis, outdoor and indoor air pollution and many others are aetiologies of COPD in non-smokers...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28202315/mycobacterium-tuberculosis-chorismate-mutase-a-potential-target-for-tb
#20
REVIEW
Manjulatha Khanapur, Mallika Alvala, Maddela Prabhakar, K Shiva Kumar, R K Edwin, P S V K Sri Saranya, Raj Kumar Patel, Gopalakrishnan Bulusu, P Misra, Manojit Pal
Mycobacterium tuberculosis chorismate mutase (MtbCM) catalyzes the rearrangement of chorismate to prephenate in the shikimate biosynthetic pathway to form the essential amino acids, phenylalanine and tyrosine. Two genes encoding chorismate mutase have been identified in Mtb. The secretory form,∗MtbCM (encoded by Rv1885c) is assumed to play a key role in pathogenesis of tuberculosis. Also, the inhibition of MtbCM may hinder the supply of nutrients to the organism. Indeed, the existence of chorismate mutase (CM) in bacteria, fungi and higher plants but not in human and low sequence homology among known CM makes it an interesting target for the discovery of anti-tubercular agents...
February 4, 2017: Bioorganic & Medicinal Chemistry
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