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https://www.readbyqxmd.com/read/29334195/exoproteome-profiling-reveals-the-involvement-of-the-foldase-prsa-in-the-cell-surface-properties-and-pathogenesis-of-staphylococcus-aureus
#1
Mei-Hui Lin, Chi-Chun Li, Jwu-Ching Shu, Hao-Wei Chu, Chao-Chin Liu, Chih-Ching Wu
Staphylococcus aureus is a bacterial pathogen that produces and exports many virulence factors that cause diseases in human. PrsA, a membrane-bound foldase, is expressed ubiquitously in Gram-positive bacteria and required for the folding of exported proteins into a stable and active structure. To understand the involvement of PrsA in post-translocational protein folding in S. aureus, a PrsA-deficient mutant of S. aureus HG001 was constructed. Using isobaric tags for relative and absolute quantification (iTRAQ)-based mass spectrometry analyses, the exoproteomes of PrsA mutant and wild type S...
January 15, 2018: Proteomics
https://www.readbyqxmd.com/read/29334018/pyoderma-gangrenosum-demographics-treatments-and-outcomes-an-analysis-of-2-273-cases
#2
Sarah E Sasor, Tahereh Soleimani, Michael W Chu, Julia A Cook, Peter J Nicksic, Sunil S Tholpady
OBJECTIVE: Pyoderma gangrenosum is a rare, neutrophil-mediated, auto-inflammatory dermatosis. This condition has clinical features analogous to infectious processes and must be quickly diagnosed to be properly treated. The purpose of this study was to characterise relevant clinical features associated with pyoderma gangrenosum based on a large inpatient cohort. METHOD: The National Inpatient Sample (US) was used to identify patients with the diagnosis of pyoderma gangrenosum using ICD-9 diagnosis code 686...
January 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333929/efficacy-of-an-imaging-device-at-identifying-the-presence-of-bacteria-in-wounds-at-a-plastic-surgery-outpatients-clinic
#3
Ellen L Blackshaw, Steven L A Jeffery
OBJECTIVE: Current standard diagnostic practice of bacterial infections by visual inspection under white light is subjective, and microbiological sampling is suboptimal due to high false negative rates and the lengthy time needed for culture results to arrive. The MolecuLight i:X Imaging Device attempts to combat the issues faced in standard practice by providing a non-contact, real-time method of visualising bacteria within wounds. Our aim was to test this imaging device in a series of patients...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333408/is-long-term-storage-of-cryopreserved-stem-cells-for-hematopoietic-stem-cell-transplantation-a-worthwhile-exercise-in-developing-countries
#4
Santhosh Kumar Devadas, Minal Khairnar, Sumathi S Hiregoudar, Shashank Ojha, Sachin Punatar, Alok Gupta, Anant Gokarn, Pallavi Bhole, Sadhana Kannan, Navin Khattry
Background: Stem cell units (SCUs) that are cryopreserved prior to both autologous and allogeneic hematopoietic stem cell transplants (for donor lymphocyte infusion) remain unused or partially used several times, and become an increased burden to blood banks/SCU repositories. Because of the scarcity of data regarding the duration for which the storage is useful, there is no general consensus regarding disposal of SCUs. Methods: We conducted a retrospective audit of SCU utilization in 435 patients who planned to undergo either autologous stem cell transplantation (auto-SCT) (N=239) or allogeneic stem cell transplantation (allo-SCT) (N=196) at a tertiary cancer care center between November 2007 to January 2015...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29331894/pharmaceutical-concentration-variability-at-sewage-treatment-plant-outlets-dominated-by-hydrology-and-other-factors
#5
Andrea F Brunsch, Thomas L Ter Laak, Huub Rijnaarts, Ekkehard Christoffels
A study was conducted in which the effluent at four small to medium sized sewage treatment plants (STP) in North Rhine-Westphalia, Germany was monitored for three pharmaceutical compounds (carbamazepine, diclofenac, metoprolol) over a period of four years. Grab sampling and auto sampling campaigns were accomplished with respect to various weather conditions in the catchment area. Flow volumes and hydraulic retention times (HRT) from various sampling dates which provide information on processes causing emission changes were additionally taken into account...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331577/a-novel-encystation-specific-protein-kinase-regulates-chitin-synthesis-in-entamoeba-invadens
#6
Sintu Kumar Samanta, Sneha Susan Varghese, Deepak Krishnan, Mithu Baidya, Digant Nayak, Sumanta Mukherjee, Sudip K Ghosh
Phosphorylation is an important post-translational modification of proteins and is involved in the regulation of a variety of cellular events. The proteome of Entamoeba invadens, the reptilian counterpart of Entamoeba histolytica consists of an overwhelming number of putative protein kinases, and some may have a role to play in Entamoeba encystation. In this study, we have identified a novel protein kinase named as EiCSpk (Entamoeba invadenscyst specific protein kinase) which expressed almost exclusively during encystation...
January 10, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29331322/expression-level-of-risk-genes-of-mhc-class-ii-is-a-susceptibility-factor-for-autoimmunity-new-insights
#7
REVIEW
Carmen Gianfran, Laura Pisapia, Stefania Picascia, Maria Strazzullo, Giovanna Del Pozzo
To date, the study of the impact of major hystocompatibility complex on autoimmunity has been prevalently focused on structural diversity of MHC molecules in binding and presentation of (auto)antigens to cognate T cells. Recently, a number of experimental evidences suggested new points of view to investigate the complex relationships between MHC gene expression and the individual predisposition to autoimmune diseases. Irrespective of the nature of the antigen, a threshold of MHC-peptide complexes needs to be reached, as well as a threshold of T cell receptors engaged is required, for the activation and proliferation of autoantigen-reactive T cells...
January 10, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29330439/induction-of-protein-citrullination-and-auto-antibodies-production-in-murine-exposed-to-nickel-nanomaterials
#8
Bashir M Mohamed, Noreen T Boyle, Anja Schinwald, Bruno Murer, Ronan Ward, Omar K Mahfoud, Tatsiana Rakovich, Kieran Crosbie-Staunton, Steven G Gray, Ken Donaldson, Yuri Volkov, Adriele Prina-Mello
Citrullination, or the post-translational deimination of polypeptide-bound arginine, is involved in several pathological processes in the body, including autoimmunity and tumorigenesis. Recent studies have shown that nanomaterials can trigger protein citrullination, which might constitute a common pathogenic link to disease development. Here we demonstrated auto-antibody production in serum of nanomaterials-treated mice. Citrullination-associated phenomena and PAD levels were found to be elevated in nanomaterials -treated cell lines as well as in the spleen, kidneys and lymph nodes of mice, suggesting a systemic response to nanomaterials injection, and validated in human pleural and pericardial malignant mesothelioma (MM) samples...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329015/modelling-of-road-traffic-fatalities-in-india
#9
Rahul Goel
Passenger modes in India include walking, cycling, buses, trains, intermediate public transport modes (IPT) such as three-wheeled auto rickshaws or tuk-tuks, motorised two-wheelers (2W) as well as cars. However, epidemiological studies of traffic crashes in India have been limited in their approach to account for the exposure of these road users. In 2011, for the first time, census in India reported travel distance and mode of travel for workers. A Poisson-lognormal mixture regression model is developed at the state level to explore the relationship of road deaths of all the road users with commute travel distance by different on-road modes...
January 9, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29328958/stdp-based-spiking-deep-convolutional-neural-networks-for-object-recognition
#10
Saeed Reza Kheradpisheh, Mohammad Ganjtabesh, Simon J Thorpe, Timothée Masquelier
Previous studies have shown that spike-timing-dependent plasticity (STDP) can be used in spiking neural networks (SNN) to extract visual features of low or intermediate complexity in an unsupervised manner. These studies, however, used relatively shallow architectures, and only one layer was trainable. Another line of research has demonstrated - using rate-based neural networks trained with back-propagation - that having many layers increases the recognition robustness, an approach known as deep learning. We thus designed a deep SNN, comprising several convolutional (trainable with STDP) and pooling layers...
December 23, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29328050/threshold-driven-optimization-for-reference-based-auto-planning
#11
Troy Long, Mingli Chen, Steve B Jiang, Weiguo Lu
We study threshold-driven optimization methodology for automatically generating a treatment plan that is motivated by a reference DVH for IMRT treatment planning. We present a framework for threshold-driven optimization for reference-based auto-planning (TORA). Commonly used voxel-based quadratic penalties have two components for penalizing under- and over-dosing of voxels: a reference dose threshold and associated penalty weight. Conventional manual- and auto-planning using such a function involves iteratively updating the preference weights while keeping the thresholds constant, an unintuitive and often inconsistent method for planning toward some reference DVH...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#12
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324921/the-correlation-of-evans-index-with-csf-protein-levels-and-ventriculomegaly
#13
D Papaoikonomou, E Karypidou, P Megagiannis, F Tsolaki-Tagaraki, S Nenopoulou, O Gkatzima, Magda Tsolaki
OBJECTIVE: The role of ventriculomegaly and its interplay between various dementia entities and their pathogenesis, as well as its correlation to the levels of CSF protein markers, remains to be elucidated. Evans index (EI) is a well-established radiological marker in the diagnosis of idiopathic Normal Pressure Hydrocephalus (iNPH), assessing ventricular enlargement. However, there are no previous studies investigating the correlation between EI, age, beta amyloid (Aβ), tau and phosphorylated-tau (p-tau) proteins in the CSF...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324476/revisiting-autologous-transplantation-in-acute-myeloid-leukemia
#14
Chezi Ganzel, Jacob M Rowe
PURPOSE OF REVIEW: Autologous hematopoietic cell transplantation (auto-HCT) has been evaluated as a consolidation treatment for acute myeloid leukemia (AML) in the 1980s and 1990s. These prospective studies from large trials compared auto-HCT with chemotherapy. A comparison was made also with allogeneic hematopoietic cell transplantation (allo-HCT). These studies reported a lower relapse rate with auto-HCT compared with chemotherapy, but without impact on the overall survival. A high transplant-related mortality in that era confounded the relevance of these data...
January 10, 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29324347/design-synthesis-and-biological-evaluation-of-7h-pyrrolo-2-3-d-pyrimidin-4-amine-derivatives-as-selective-btk-inhibitors-with-improved-pharmacokinetic-properties-for-the-treatment-of-rheumatoid-arthritis
#15
Linhong He, Heying Pei, Chufeng Zhang, Mingfeng Shao, Dan Li, Mingli Tang, Taijing Wang, Xiaoxin Chen, Mingli Xiang, Lijuan Chen
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheumatoid arthritis (RA). We reported a series of compounds bearing 7H-pyrrolo [2,3-d]pyrimidin-4-amine scaffold that potently inhibited Btk in vitro. Analysis of the structure-activity relationships (SAR) and drug-like profiles led to the discovery of the optimal compound B16...
December 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29323363/high-efficiency-x-ray-luminescence-in-eu3-activated-tungstate-nanoprobes-for-optical-imaging-through-energy-transfer-sensitization
#16
Tao Guo, Yan Lin, Wei-Jian Zhang, Jin-Sheng Hong, Ru-Hui Lin, Xiao-Ping Wu, Juan Li, Chun-Hua Lu, Huang-Hao Yang
X-ray luminescence optical imaging has been recognized as a powerful technique for medical diagnosis due to its deep penetration and low auto-fluorescence in tissues. However, the low luminescence efficiency of current X-ray luminescence nanoprobes remains a major hurdle for sensitive bioimaging in practical medical applications. Here we present a new kind of energy transfer-sensitized X-ray luminescence nanoprobe (PEG-NaGd(WO4)2:Eu) for highly effective optical bioimaging. Under X-ray excitation, the tungstate host absorbs the X-ray photons and then transfers the energy to the Eu3+ luminescence center, thus enhancing the luminescence efficiency of the nanoprobes for high sensitivity optical in vivo imaging...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29322360/highly-conserved-arg-residue-of-erfnin-motif-of-pro-domain-is-important-for-ph-induced-zymogen-activation-process-in-cysteine-cathepsins-k-and-l
#17
Pulakesh Aich, Sampa Biswas
Pro-domain of a cysteine cathepsin contains a highly conserved Ex2Rx2Fx2Nx3Ix3N (ERFNIN) motif. The zymogen structure of cathepsins revealed that the Arg(R) residue of the motif is a central residue of a salt-bridge/H-bond network, stabilizing the scaffold of the pro-domain. Importance of the arginine is also demonstrated in studies where a single mutation (Arg → Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis". In the present study, we have characterized in vitro Arg → Trp mutant of hCTSK and the same mutant of hCTSL...
January 10, 2018: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29322025/short-and-long-term-impact-of-parathyroid-autotransplantation-on-parathyroid-function-after-total-thyroidectomy
#18
REVIEW
Gabrielle Hicks, Robert George, Mark Sywak
The most common complication of total thyroidectomy is parathyroid insufficiency. Acute, transient, post-operative hypoparathyroidism increases length of hospitalization, morbidity and cost associated with total thyroidectomy. While permanent hypoparathyroidism poses a significant medical burden with lifetime medication, regular follow up and considerable disease burden related to chronic renal failure and other sequelae. Parathyroid autotransplantation has been demonstrated to result in biochemically functional grafts, leading to the procedures' common use during total thyroidectomy...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29321823/yin-and-yang-of-mesenchymal-stem-cells-and-aplastic-anemia
#19
REVIEW
Larisa Broglie, David Margolis, Jeffrey A Medin
Acquired aplastic anemia (AA) is a bone marrow failure syndrome characterized by peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment, most commonly from infection or hemorrhage. Current treatments focus on suppressing immune-mediated destruction of bone marrow stem cells or replacing hematopoietic stem cells (HSCs) by transplantation. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Mesenchymal stem cells (MSCs) play a vital role in HSC proliferation; they also modulate immune responses and maintain an environment supportive of hematopoiesis...
December 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29319821/probiotic-potency-of-lactobacillus-plantarum-kx519413-and-kx519414-isolated-from-honey-bee-gut
#20
C Honey Chandran, T R Keerthi
The Indian honey bee-Apis cerana indica, which harbors an abundant and diverse range of lactic acid bacteria (LAB) in their gut with beneficial effects was used as the source for the isolation of LAB. In the present study, two LAB isolates from honey bee gut were selected primarily based on their phenotypic and selective biochemical characterization, further PCR and identified using 16S rRNA sequencing as Lactobacillus plantarum and were registered in National Centre for Biotechnology Information (NCBI) under accession number KX519413 and KX519414...
January 8, 2018: FEMS Microbiology Letters
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