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https://www.readbyqxmd.com/read/28346535/caudwell-xtreme-everest-a-prospective-study-of-the-effects-of-environmental-hypoxia-on-cognitive-functioning
#1
Konstadina Griva, Jan Stygall, Mark H Wilson, Daniel Martin, Denny Levett, Kay Mitchell, Monty Mythen, Hugh E Montgomery, Mike P Grocott, Golnar Aref-Adib, Mark Edsell, Tracie Plant, Chris Imray, Debbie Cooke, Jane Harrington, Maryam Khosravi, Stanton P Newman
BACKGROUND: The neuropsychological consequences of exposure to environmental hypobaric hypoxia (EHH) remain unclear. We thus investigated them in a large group of healthy volunteers who trekked to Mount Everest base camp (5,300 m). METHODS: A neuropsychological (NP) test battery assessing memory, language, attention, and executive function was administered to 198 participants (age 44.5±13.7 years; 60% male). These were studied at baseline (sea level), 3,500 m (Namche Bazaar), 5,300 m (Everest Base Camp) and on return to 1,300 m (Kathmandu) (attrition rate 23...
2017: PloS One
https://www.readbyqxmd.com/read/28341594/itraq-based-proteomics-analysis-of-hippocampus-in-spatial-memory-deficiency-rats-induced-by-simulated-microgravity
#2
Tingmei Wang, Hailong Chen, Ke Lv, Guohua Ji, Yongliang Zhang, Yanli Wang, Yinghui Li, Lina Qu
It has been demonstrated that simulated microgravity (SM) may lead to cognitive dysfunction. However, the underlying mechanism remains unclear. In present study, tail-suspension (30°) rat was employed to explore the effects of 28 days of SM on hippocampus-dependent learning and memory capability and the underlying mechanisms. We found that 28-day tail-suspension rats displayed decline of learning and memory ability in Morris water maze (MWM) test. Using iTRAQ-based proteomics analysis, a total of 4774 proteins were quantified in hippocampus...
March 21, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28339685/information-needs-of-generalists-and-specialists-using-online-best-practice-algorithms-to-answer-clinical-questions
#3
David A Cook, Kristi J Sorensen, Jane A Linderbaum, Laurie J Pencille, Deborah J Rhodes
Objective: : To better understand clinician information needs and learning opportunities by exploring the use of best-practice algorithms across different training levels and specialties. Methods: : We developed interactive online algorithms (care process models [CPMs]) that integrate current guidelines, recent evidence, and local expertise to represent cross-disciplinary best practices for managing clinical problems. We reviewed CPM usage logs from January 2014 to June 2015 and compared usage across specialty and provider type...
February 19, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28334023/preferences-for-the-provision-of-whole-genome-sequencing-services-among-young-adults
#4
Christopher H Wade, Kailyn R Elliott
OBJECTIVES: As whole genome sequencing (WGS) becomes increasingly available, clinicians will be faced with conveying complex information to individuals at different stages in life. The purpose of this study is to characterize the views of young adults toward obtaining WGS, learning different types of genomic information, and having choice about which results are disclosed. METHODS: A mixed-methods descriptive study was conducted with a diverse group of 18 and 19-years-olds (N = 145)...
2017: PloS One
https://www.readbyqxmd.com/read/28333228/efficacy-of-ovarian-tissue-cryopreservation-for-fertility-preservation-lessons-learned-from-545-cases
#5
P Jadoul, A Guilmain, J Squifflet, M Luyckx, R Votino, C Wyns, M M Dolmans
STUDY QUESTION: How effective is ovarian tissue cryopreservation (OTC)? SUMMARY ANSWER: In our cohort of patients who underwent OTC, premature ovarian failure (POF) rates, return rates and pregnancy rates after autotransplantation were 31.5, 4.4 and 33%, respectively. WHAT IS KNOWN ALREADY: OTC for fertility purposes has been performed for >20 years now. With over 86 live births reported worldwide and success rates of ~30% after autotransplantation of frozen-thawed ovarian cortex, the procedure should no longer be considered experimental...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332110/minimizing-injury-and-maximizing-return-to-play-lessons-from-engineered-ligaments
#6
REVIEW
Keith Baar
Musculoskeletal injuries account for more than 70% of time away from sports. One of the reasons for the high number of injuries and long return to play is that we have only a very basic understanding of how our training alters tendon and ligament (sinew) structure and function. Sinews are highly dense tissues that are difficult to characterize both in vivo and in vitro. Recently, engineered ligaments have been developed in vitro using cells from human anterior cruciate ligaments or hamstring tendons. These three-dimensional tissues can be grown in a laboratory, treated with agents thought to affect sinew physiology, and then mechanically tested to determine their function...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28323679/the-day-that-went-missing-a-first-person-account-of-transient-global-amnesia
#7
Trip Gabriel
In this vivid first-person case history, political reporter Trip Gabriel describes experiencing a classic episode of transient global amnesia. He was near the average target age of 61. Although no cause has been established for the syndrome, as with many other patients his episode appears to have been triggered by contact with water: He was racing a sailboat. While remaining alert and handling complex sailing maneuvers, he suddenly developed amnesia that left him with no recollection of finishing two races, returning to shore, drinking a beer with his friends, needing help finding his car, and not knowing where he was or where he lived...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28316348/new-skills-new-jobs-return-migration-skill-transfers-and-business-formation-in-mexico
#8
Jacqueline Maria Hagan, Joshua Wassink
Numerous studies have documented a high propensity for self-employment and business formation among return migrants relative to non-migrants. The literature points to the importance of remitted savings, migration duration, and number and types of jobs abroad for business formation upon return. Implicit in this scholarship is the assumption that migrants acquire not only financial capital, but also human capital, which expands their opportunities upon return. Empirical work has demonstrated how the transfer of formal human capital, such as language skills and professional credentials, influences the mobility pathways of professional return migrants...
November 2016: Social Problems
https://www.readbyqxmd.com/read/28314495/global-service-learning-and-student-athletes-a-model-for-enhanced-academic-inclusion-at-the-university-of-washington
#9
Holly M Barker
BACKGROUND: The University of Washington (UW) continues to create opportunities to engage all students in transformational undergraduate educational opportunities, such as study abroad. OBJECTIVE: This article describes specific efforts to increase inclusion for student-athletes in study abroad, particularly for first-generation students, including low-income students of color. Given the overrepresentation of students of color in sports vis-à-vis the larger student body at predominantly white institutions (PWIs), like UW, service-learning in communities beyond campus boundaries provides opportunities to apply international learning to a local context and to create a continuum of learning...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28304001/students-perceptions-of-usefulness-of-anatomy-demonstrations-in-traditional-and-hybrid-undergraduate-medical-education-curricula
#10
Ayesha Saba Naz, Rehana Rehman, Zehra Jamil, Khalid Ahmed, Ambreen Surti
A cross-sectional study was carried out to study students' perceptions on the usefulness of Anatomy demonstrations (AD) in the undergraduate medical education by comparing the Conventional Medical College (CMC) and problem-based learning as hybrid curriculum (HMC). Purposive sampling technique was used and all students were included. The completed questionnaire responses were returned by 92 CMC and 87 HMC students. CMC cohort understood the structural relationship more than HMC (p=0.03). AD helped 50 students (54%) of CMC to get through the theory examination, however 73 (84%) students of HMC found them useful in preparation for theory examinations (p<0...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28296930/seasonal-changes-in-the-digesta-adherent-rumen-bacterial-communities-of-dairy-cattle-grazing-pasture
#11
Samantha J Noel, Graeme T Attwood, Jasna Rakonjac, Christina D Moon, Garry C Waghorn, Peter H Janssen
The complex microbiota that resides within the rumen is responsible for the break-down of plant fibre. The bacteria that attach to ingested plant matter within the rumen are thought to be responsible for initial fibre degradation. Most studies examining the ecology of this important microbiome only offer a 'snapshot' in time. We monitored the diversity of rumen bacteria in four New Zealand dairy cows, grazing a rye-grass and clover pasture over five consecutive seasons, using high throughput pyrosequencing of bacterial 16S rRNA genes...
2017: PloS One
https://www.readbyqxmd.com/read/28293137/nonlinear-information-fusion-algorithms-for-data-efficient-multi-fidelity-modelling
#12
P Perdikaris, M Raissi, A Damianou, N D Lawrence, G E Karniadakis
Multi-fidelity modelling enables accurate inference of quantities of interest by synergistically combining realizations of low-cost/low-fidelity models with a small set of high-fidelity observations. This is particularly effective when the low- and high-fidelity models exhibit strong correlations, and can lead to significant computational gains over approaches that solely rely on high-fidelity models. However, in many cases of practical interest, low-fidelity models can only be well correlated to their high-fidelity counterparts for a specific range of input parameters, and potentially return wrong trends and erroneous predictions if probed outside of their validity regime...
February 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28291482/understanding-post-deployment-reintegration-concerns-among-en-route-care-nurses-a-mixed-methods-approach
#13
Felecia M Rivers, Susan Dukes, Jennifer Hatzfeld, Linda H Yoder, Sandra Gordon, Angela Simmons
The objective of this study was to better understand the post-deployment behavior health symptoms and readjustment/reintegration experienced by military nurses who provided en route care while serving in Operation Enduring Freedom/Operation Iraqi Freedom. Employing an exploratory, concurrent, mixed-methods design with an electronic survey consisting of several valid instruments and single, face-to-face interviews; data were gathered from 119 surveys and 22 interviews. Four qualitative themes aligned with the Post-Deployment Readjustment Inventory items...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290955/dynamic-insights-on-surgical-activity-in-a-new-modern-warfare-the-french-role-2-in-bangui-central-african-republic
#14
Olivier Barbier, Pierre Pasquier, Maelle Racle, Yoann Baudoin, Brice Malgras
INTRODUCTION: In December 2013, France deployed more than 2,000 soldiers in Central African Republic with two main missions, to restore security and to improve the humanitarian situation. The objectives of this article were to analyze the surgical activity of forward surgical teams in Central African Republic over 2 years and to discuss features of training for deployed surgeons. MATERIALS AND METHODS: From December 5, 2013, to September 30, 2015, we retrospectively reviewed the electronic surgical database...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287682/return-to-school-and-learning-after-concussion-tips-for-pediatricians
#15
Matthew F Grady, Christina L Master
Concussion in children and adolescents is a common injury that is usually managed by the primary care provider. Students with a concussion may present with a variety of symptoms, and these symptoms interfere with regular school participation. Optimizing the timing and progression of return to school and learning is often challenging, but with a careful history and concussion-specific examination, the primary care provider can identify potential barriers to school reentry. This review focuses on developing a systematic approach to the initial concussion evaluation and developing customized school accommodations to aid in the school reentry process...
March 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28280383/nurses-and-opioids-results-of-a-bi-national-survey-on-mental-models-regarding-opioid-administration-in-hospitals
#16
Charlotte Guest, Fabian Sobotka, Athina Karavasopoulou, Stephen Ward, Carsten Bantel
OBJECTIVE: Pain remains insufficiently treated in hospitals. Increasing evidence suggests human factors contribute to this, due to nurses failing to administer opioids. This behavior might be the consequence of nurses' mental models about opioids. As personal experience and conceptions shape these models, the aim of this prospective survey was to identify model-influencing factors. MATERIAL AND METHODS: A questionnaire was developed comprising of 14 statements concerning ideations about opioids and seven questions concerning demographics, indicators of adult learning, and strength of religious beliefs...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28277728/employees-on-the-rebound-extending-the-careers-literature-to-include-boomerang-employment
#17
Brian W Swider, Joseph T Liu, T Brad Harris, Richard G Gardner
As employee careers have evolved from linear trajectories confined within 1 organization to more dynamic and boundaryless paths, organizations and individuals alike have increasingly considered reestablishing prior employment relationships. These "boomerang employees" follow career paths that feature 2 or more temporally separated tenures in particular organizations ("boomerang organizations"). Yet, research to date is mute on how or to what extent differences across boomerang employees' career experiences, and the learning and knowledge developed at and away from boomerang organizations, meaningfully impact their performance following their return...
March 9, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28274812/pediatric-cardiac-arrest-due-to-drowning-and-other-respiratory-etiologies-neurobehavioral-outcomes-in-initially-comatose-children
#18
Beth S Slomine, Vinay M Nadkarni, James R Christensen, Faye S Silverstein, Russell Telford, Alexis Topjian, Joshua D Koch, Jill Sweney, Ericka L Fink, Mudit Mathur, Richard Holubkov, J Michael Dean, Frank W Moler
AIM: To describe the 1-year neurobehavioral outcome of survivors of cardiac arrest secondary to drowning, compared with other respiratory etiologies, in children enrolled in the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial. METHODS: Exploratory analysis of survivors (ages 1-18 years) who received chest compressions for ≥2min, were comatose, and required mechanical ventilation after return of circulation (ROC). Participants recruited from 27 pediatric intensive care units in North America received targeted temperature management [therapeutic hypothermia (33°C) or therapeutic normothermia (36...
March 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/28274765/engineering-mechanical-gradients-in-next-generation-biomaterials-lessons-learned-from-medical-textile-design
#19
Joanna L Ng, Ciara E Collins, Melissa L Knothe Tate
Nonwoven and textile membranes have been applied both externally and internally to prescribe boundary conditions for medical conditions as diverse as oedema and tissue defects. Incorporation of mechanical gradients in next generation medical membrane design offers great potential to enhance function in a dynamic, physiological context. Yet the gradient properties and resulting mechanical performance of current membranes are not well described. To bridge this knowledge gap, we tested and compared the mechanical properties of bounding membranes used in both external (compression sleeves for oedema, exercise bands) and internal (surgical membranes) physiological contexts...
March 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28274244/where-is-students-research-in-evidence-informed-decision-making-in-health-assessing-productivity-and-use-of-postgraduate-students-research-in-low-and-middle-income-countries-a-systematic-review
#20
E A Obuku, J N Lavis, A Kinengyere, D K Mafigiri, F Sengooba, C Karamagi, N K Sewankambo
BACKGROUND: Investing in research that is not accessible or used is a waste of resources and an injustice to human subject participants. Post-graduate students' research in institutions of higher learning involves considerable time, effort and money, warranting evaluation of the return on investment. Although individual studies addressing research productivity of post-graduate students are available, a synthesis of these results in low-income settings has not been undertaken. Our first aim is to identify the types of approaches that increase productivity and those that increase the application of medical post-graduate students' research and to assess their effectiveness...
March 9, 2017: Health Research Policy and Systems
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