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https://www.readbyqxmd.com/read/28210980/molecular-mechanisms-of-ire1%C3%AE-ask1-pathway-reactions-to-unfolded-protein-response-in-drn-neurons-of-post-traumatic-stress-disorder-rats
#1
Fanzhen Kong, Fang Han, Yanhao Xu, Yuxiu Shi
The goal of this study was to further elucidate the molecular mechanisms of post-traumatic stress disorder (PTSD) pathogenesis and to provide experimental evidence for new drug targets for effective PTSD treatment. Expression changes of IRE1α, ASK1, and other downstream molecules of the IRE1α-ASK1 endoplasmic reticulum stress (ERS) signaling pathway were investigated. JNK, P38, CHOP, Bcl-2, and Bax were analyzed at both protein and mRNA levels of dorsal raphe nucleus (DRN) neurons of PTSD rats. The rat PTSD model was established via the single-prolonged stress (SPS) method...
February 16, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28205499/motor-adaptation-deficits-in-ideomotor-apraxia
#2
Pratik K Mutha, Lee H Stapp, Robert L Sainburg, Kathleen Y Haaland
OBJECTIVES: The cardinal motor deficits seen in ideomotor limb apraxia are thought to arise from damage to internal representations for actions developed through learning and experience. However, whether apraxic patients learn to develop new representations with training is not well understood. We studied the capacity of apraxic patients for motor adaptation, a process associated with the development of a new internal representation of the relationship between movements and their sensory effects...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28196139/using-data-from-the-microsoft-kinect-2-to-determine-postural-stability-in-healthy-subjects-a-feasibility-trial
#3
Behdad Dehbandi, Alexandre Barachant, Anna H Smeragliuolo, John Davis Long, Silverio Joseph Bumanlag, Victor He, Anna Lampe, David Putrino
The objective of this study was to determine whether kinematic data collected by the Microsoft Kinect 2 (MK2) could be used to quantify postural stability in healthy subjects. Twelve subjects were recruited for the project, and were instructed to perform a sequence of simple postural stability tasks. The movement sequence was performed as subjects were seated on top of a force platform, and the MK2 was positioned in front of them. This sequence of tasks was performed by each subject under three different postural conditions: "both feet on the ground" (1), "One foot off the ground" (2), and "both feet off the ground" (3)...
2017: PloS One
https://www.readbyqxmd.com/read/28180146/-i-think-we-ve-got-too-many-tests-prenatal-providers-reflections-on-ethical-and-clinical-challenges-in-the-practice-integration-of-cell-free-dna-screening
#4
B L Gammon, S A Kraft, M Michie, M Allyse
BACKGROUND: The recent introduction of cell-free DNA-based non-invasive prenatal screening (cfDNA screening) into clinical practice was expected to revolutionize prenatal testing. cfDNA screening for fetal aneuploidy has demonstrated higher test sensitivity and specificity for some conditions than conventional serum screening and can be conducted early in the pregnancy. However, it is not clear whether and how clinical practices are assimilating this new type of testing into their informed consent and counselling processes...
July 2016: Ethics, Medicine, and Public Health
https://www.readbyqxmd.com/read/28179893/professionalism-and-occupational-well-being-similarities-and-differences-among-latin-american-health-professionals
#5
Montserrat San-Martín, Roberto Delgado-Bolton, Luis Vivanco
Context: Empathy, teamwork, and lifelong learning are described as key elements of professionalism. The first recipients of their benefits are professionals themselves. Paradoxically, scarce studies have reported association between professionalism and occupational well-being. The main purpose of this study was to characterize the influence that empathy, teamwork, and lifelong learning, play in the occupational well-being of physicians and nurses working in Latin American healthcare institutions. Materials and Methods: The Jefferson Scale of Empathy, the Jefferson Scale of Attitudes toward Physician-Nurse Collaboration, the Jefferson Scale of Physicians Lifelong Learning, and the Scale of Collateral Effects (somatization, exhaustion, and work alienation), were administered to 522 physicians and nurses working in institutions of Mexico, Colombia, Ecuador, and Argentina...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28178266/accuracy-maximization-analysis-for-sensory-perceptual-tasks-computational-improvements-filter-robustness-and-coding-advantages-for-scaled-additive-noise
#6
Johannes Burge, Priyank Jaini
Accuracy Maximization Analysis (AMA) is a recently developed Bayesian ideal observer method for task-specific dimensionality reduction. Given a training set of proximal stimuli (e.g. retinal images), a response noise model, and a cost function, AMA returns the filters (i.e. receptive fields) that extract the most useful stimulus features for estimating a user-specified latent variable from those stimuli. Here, we first contribute two technical advances that significantly reduce AMA's compute time: we derive gradients of cost functions for which two popular estimators are appropriate, and we implement a stochastic gradient descent (AMA-SGD) routine for filter learning...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28174480/effects-of-aerobic-and-anaerobic-exercise-on-spatial-learning-ability-in-hypothyroid-rats-a-pilot-study
#7
Sung-Hyun Park, MinYoung Song
[Purpose] This pilot study analyzed the degradation of spatial learning ability caused by hypothyroidism using aerobic and anaerobic exercise. [Subjects and Methods] The experiments were performed on 11, four-week-old male Sprague-Dawley rats. Hypothyroidism-induced rats receiving propylthiouracil (PTU) treatment were divided into aerobic exercise, anaerobic exercise, and control groups. Each group performed exercise and rest for four weeks. Changes in lethargy, memory deterioration, and thyroid function were measured in each group by blood analysis and open field and Morris water maze tests...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28167910/adaptive-baseline-enhances-em-based-policy-search-validation-in-a-view-based-positioning-task-of-a-smartphone-balancer
#8
Jiexin Wang, Eiji Uchibe, Kenji Doya
EM-based policy search methods estimate a lower bound of the expected return from the histories of episodes and iteratively update the policy parameters using the maximum of a lower bound of expected return, which makes gradient calculation and learning rate tuning unnecessary. Previous algorithms like Policy learning by Weighting Exploration with the Returns, Fitness Expectation Maximization, and EM-based Policy Hyperparameter Exploration implemented the mechanisms to discard useless low-return episodes either implicitly or using a fixed baseline determined by the experimenter...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28167171/professional-ballet-dancers-experience-of-injury-and-osteopathic-treatment-in-the-uk-a-qualitative-study
#9
Tobias Pollard-Smith, Oliver P Thomson
OBJECTIVES: Professional dancers suffer significant musculoskeletal injuries during the course of their careers. Treatment-seeking behaviour is important in all patient populations, yet is rarely investigated amongst professional dancers. This qualitative study aimed to form a better understanding of how dancers decide to seek treatment, and in particular to explore their experiences of receiving osteopathic care for their injuries. METHODS: A qualitative study design using grounded theory was used as a methodological framework for data collection and analysis...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28166759/sexual-health-status-of-women-who-have-regular-sexual-relations-with-men-who-have-sex-with-men-in-mainland-china
#10
Xiufang Li, Beichuan Zhang, Juan Wang, Yang Li, Xianhong Li, Peiheng Yu, Minghua Liu, Xinqiao Liu
BACKGROUND: Men who have sex with men (MSM) are a high-risk group for sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV) infection. In China, the vast majority of MSM feel forced to marry or plan to marry women, according to traditional Chinese culture. Women who have regular sexual relations with MSM, called tongqi in mainland China, live with a high risk of STDs or HIV infection, but these risks are often ignored. Our investigation of this group of the women is a preliminary study that aims to understand the sexual health problems of tongqi and related factors...
February 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28166512/pareto-optimal-model-selection-via-sprint-race
#11
Tiantian Zhang, Michael Georgiopoulos, Georgios C Anagnostopoulos
In machine learning, the notion of multi-objective model selection (MOMS) refers to the problem of identifying the set of Pareto-optimal models that optimize by compromising more than one predefined objectives simultaneously. This paper introduces SPRINT-Race, the first multi-objective racing algorithm in a fixed-confidence setting, which is based on the sequential probability ratio with indifference zone test. SPRINT-Race addresses the problem of MOMS with multiple stochastic optimization objectives in the proper Pareto-optimality sense...
January 30, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28158189/insect-bio-inspired-neural-network-provides-new-evidence-on-how-simple-feature-detectors-can-enable-complex-visual-generalization-and-stimulus-location-invariance-in-the-miniature-brain-of-honeybees
#12
Mark Roper, Chrisantha Fernando, Lars Chittka
The ability to generalize over naturally occurring variation in cues indicating food or predation risk is highly useful for efficient decision-making in many animals. Honeybees have remarkable visual cognitive abilities, allowing them to classify visual patterns by common features despite having a relatively miniature brain. Here we ask the question whether generalization requires complex visual recognition or whether it can also be achieved with relatively simple neuronal mechanisms. We produced several simple models inspired by the known anatomical structures and neuronal responses within the bee brain and subsequently compared their ability to generalize achromatic patterns to the observed behavioural performance of honeybees on these cues...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28152155/bullying-in-senior-living-facilities-perspectives-of-long-term-care-staff
#13
Felicia J Andresen, Jeffrey A Buchanan
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
February 2, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28152153/aspects-of-self-and-identity-in-narrations-about-recent-events-communication-with-individuals-with-alzheimer-s-disease-enabled-by-a-digital-photograph-diary
#14
Eva Karlsson, Karin Zingmark, Karin Axelsson, Stefan Sävenstedt
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
February 2, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28143819/performing-international-outreach-phun-week-in-an-australian-primary-school
#15
Patricia A Halpin
Physiology Understanding (PhUn) Week is an annual science outreach program sponsored by the American Physiological Society in which K-12 students learn about physiology through meeting a physiologist and performing an experiment. Performing PhUn Week at an Australian private primary school during a family vacation in 2014 enabled me to receive a fellowship to return the following year for further implementation. To set up the outreach, I contacted the assistant principal of a public primary school, and she connected me with the physical education (PE) teacher...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28141781/low-dose-hydrocortisone-has-acute-enhancing-effects-on-verbal-learning-in-hiv-infected-men
#16
Leah H Rubin, K Luan Phan, Sheila M Keating, Kathleen M Weber, Pauline M Maki
OBJECTIVE: Glucocorticoids are released in response to stress and alter cognition and brain function through both rapid, nongenomic and slow, genomic mechanisms. Administration of glucocorticoids in the form of hydrocortisone enhances aspects of learning and memory in individuals with PTSD, but impairs these abilities in healthy individuals. We examine the time-dependent effects of glucocorticoids on cognition in HIV-infected men. METHODS: In a double-blind, placebo-controlled, cross-over study, we examined the time-dependent effects of a single low dose of hydrocortisone (10mg; LDH) on cognition in 45 HIV-infected men...
January 30, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28135379/comparison-of-nurses-self-reported-and-objectively-measured-evidence-based-practice-knowledge
#17
Amy Hagedorn Wonder, Angela M McNelis, Darrell Spurlock, Pamela M Ironside, Shelley Lancaster, Carmen R Davis, Marlena Gainey, Nancy Verwers
BACKGROUND: This study provides a first-time, objective assessment of the evidence-based practice (EBP) knowledge of RNs working in Magnet(®)-designated hospitals. METHOD: This multisite, cross-sectional, descriptive, correlational study uses the Evidence-Based Practice Knowledge Assessment in Nursing (EKAN) and Evidence-Based Practice Questionnaire (EBPQ). RESULTS: EBPQ subscale scores revealed overall positive self-ratings of EBP knowledge/skills, attitudes, and practice/use...
1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28130573/-school-re-integration-after-child-brain-dislocation-the-trauma-surgeon-s-role
#18
A Gänsslen, T Neubauer, C Hartl, N Moser, E Rickels, H Lüngen, M Nerlich, W Krutsch
Concussion injury of the brain is still a frequently underestimated injury, which can be associated with long-lasting consequences. Compared to adults, the recovery phase is often prolonged in childhood. Primary treatment consists of symptom-dependent physical and mental activities. Re-integration into daily life is crucial. In childhood, the primary focus is therefore on returning to school. New symptoms, or an increased presence of symptoms must be detected, to avoid prolonged recovery courses. School restrictions have to be minimized...
January 27, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28129710/interventions-for-resuming-driving-after-traumatic-brain-injury
#19
Pamela E Ross, Marilyn Di Stefano, Judith Charlton, Gershon Spitz, Jennie L Ponsford
PURPOSE: To describe the goals, processes, resources and outcomes of on-road training lessons provided to drivers with traumatic brain injury (TBI) who failed an initial occupational therapy (OT) driver assessment. METHOD: Descriptive cohort study using file audit design of 340 drivers with mild to severe TBI. Measures included; number and goals of on-road training lessons and reassessments, time from injury to independent driving, license restrictions, years licensed, physical/visual impairments and injury severity...
January 27, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28127116/evidence-against-observational-spatial-memory-for-cache-locations-of-conspecifics-in-marsh-tits-poecile-palustris
#20
A Utku Urhan, Ellen Emilsson, Anders Brodin
ABSTRACT: Many species in the family Paridae, such as marsh tits Poecile palustris, are large-scale scatter hoarders of food that make cryptic caches and disperse these in large year-round territories. The perhaps most well-known species in the family, the great tit Parus major, does not store food itself but is skilled in stealing caches from the other species. We have previously demonstrated that great tits are able to memorise positions of caches they have observed marsh tits make and later return and steal the food...
2017: Behavioral Ecology and Sociobiology
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