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https://www.readbyqxmd.com/read/28914395/repetitive-on-demand-drug-release-from-polymeric-matrices-containing-a-macroscopic-spherical-iron-core
#1
Stefan A Rovers, Maartje F Kemmere, Jos T F Keurentjes, Richard Hoogenboom
A system for multiple on-demand drug release has been prepared that can be activated with an alternating magnetic field as external trigger. The core/shell samples have been developed based on a macroscopic spherical iron core coated with a thermoresponsive polymer, poly(styrene-stat-butyl methacrylate), containing ibuprofen as a model drug. During exposure of the samples to the magnetic field (ON state), the release rate of ibuprofen is significantly increased, up to 35 times the release rate without the magnetic field (OFF state)...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28906387/a-nearly-full-recovery-from-avm-hemorrhagic-stroke-17-years-after-insult-using-a-new-integrated-neurodevelopmental-approach-a-case-report
#2
Alberto J Friedmann
RATIONAL: With the prevalence of stroke increasing in the USA and the world along with increased survival and longevity due to medical advancements, it has become increasingly necessary to look at the chronic phase of stroke recovery. Previous paradigms of stroke treatment have proven ineffective when looking at 10, 15, or 20 years of survival post insult. PATIENT CONCERNS: The patient, being a young man just out of high school, was concerned with his overall morbidity...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28904396/the-failure-of-clara-thompson-s-ferenczian-proxy-analysis-of-harry-stack-sullivan
#3
Kathleen Meigs
After hearing Ferenczi's talks on theory and practice in New York in 1926, psychiatrist Harry Stack Sullivan urged his friend and colleague Clara Thompson to get analyzed by Ferenczi so they could learn his technique. After saving for 2 years Thompson was a patient of Ferenczi for three summers and then moved to Budapest full-time for analysis until Ferenczi's death. Two years after she returned to New York she attempted to analyze Sullivan. Analysis was broken off in anger by Sullivan after 14 months. Before the promised Ferenczian analysis began Thompson discovered Wilhelm Reich's Character Analysis (1933) and she tried an aggressive attack on character with Sullivan rather than Ferenczian trauma-oriented "relaxation" and "neocathartic" therapy...
September 13, 2017: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28900572/return-to-running-following-a-knee-disarticulation-amputation-a-case-report
#4
Angela R Diebal-Lee, Robert S Kuenzi, Christopher A Rábago
BACKGROUND AND PURPOSE: The evolution of running-specific prostheses has empowered athletes with lower extremity amputations to run farther and faster than previously thought possible; but running with proper mechanics is still paramount to an injury-free, active lifestyle. The purpose of this case report was to describe the successful alteration of intact limb mechanics from a Rearfoot Striking (RFS) to a Non-Rearfoot Striking (NRFS) pattern in an individual with a knee disarticulation amputation, the associated reduction in Average Vertical Loading Rate (AVLR), and the improvement in functional performance following the intervention...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28887828/opportunities-for-students-to-prescribe-an-evaluation-of-185-consultations-in-the-student-run-cardiovascular-risk-management-programme
#5
Tim Schutte, Katinka Prince, Milan Richir, Erik Donker, Leonie van Gastel, Ferdynand Bastiaans, Henk de Vries, Jelle Tichelaar, Michiel van Agtmael
Involving students in CVRM could offer patients a structured CVRM programme and students a valuable learning opportunity. We describe and evaluate a student-run CVRM programme that was set up to offer primary prevention to patients with known risk factors in a general practitioner's practice. During a consultation, two undergraduate medical students assessed the patients' actual risk and formulated a CVRM plan, which they discussed with the patient after approval by a GP. After the consultations, patients were asked to complete evaluation/feedback questionnaires...
September 9, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28885869/improving-student-engagement-in-veterinary-business-studies
#6
Elizabeth Armitage-Chan, Elizabeth Jackson
In a densely packed veterinary curriculum, students may find it particularly challenging to engage in the less overtly clinical subjects, yet pressure from industry and an increasingly competitive employment market necessitate improved veterinary student education in business and management skills. We describe a curriculum intervention (formative reflective assignment) that optimizes workplace learning opportunities and aims to provide better student scaffolding for their in-context business learning. Students were asked to analyze a business practice they experienced during a period of extra-mural studies (external work placement)...
September 8, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28880741/the-impact-of-repeated-organophosphorus-pesticide-exposure-on-biomarkers-and-neurobehavioral-outcomes-among-adolescent-pesticide-applicators
#7
Ahmed A Ismail, Kai Wang, James R Olson, Matthew R Bonner, Olfat Hendy, Gaafar Abdel Rasoul, Diane S Rohlman
Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880132/linking-spinal-cord-injury-rehabilitation-between-the-world-wars-the-r-tait-mckenzie-legacy
#8
John F Ditunno
Spinal cord injury (SCI) medicine emerged after World War II due to mass casualties, which required specialized treatment centers. This approach to categorical care, however, was first developed during World War I, led by pioneers R. Tait McKenzie and George Deaver, who demonstrated that soldiers disabled by paralysis could return to society through fitness/mobility, recreational and vocational training. McKenzie, a Canadian and the first professor of physical therapy in the US, influenced Deaver and military physicians in Britain, Canada, and the U...
September 7, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28879069/biking-practices-and-preferences-in-a-lower-income-primarily-minority-neighborhood-learning-what-residents-want
#9
Anne C Lusk, Albert Anastasio, Nicholas Shaffer, Juan Wu, Yanping Li
This paper examines if, in a lower-income minority neighborhood, bicycling practices and bicycle-environment preferences of Blacks and Hispanics were different from Whites. During the summer of 2014, surveys were mailed to 1537 households near a proposed cycle track on Malcolm X Boulevard in Roxbury, MA. On the Boulevard, intercept surveys were distributed to cyclists and observations noted about passing cyclist's characteristics. Data were analyzed from 252 returned-mailed surveys, 120 intercept surveys, and 709 bicyclists...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28877104/activation-of-%C3%AE-adrenoceptor-facilitates-active-avoidance-learning-through-enhancement-of-glutamate-levels-in-the-hippocampal-dentate-gyrus
#10
Jing Lv, Hao Feng, Ling Chen, Wei-Yao Wang, Xue-Ling Yue, Qing-Hua Jin
Long-term potentiation (LTP) is widely accepted as the best studied model for neurophysiological mechanisms that could underlie learning and memory formation. Despite a number of studies indicating that β-adrenoceptors in the hippocampal dentate gyrus (DG) is involved in the modulation of learning and memory as well as LTP, few studies have used glutamate release as a visual indicator in awake animals to explore the role of β-adrenoceptors in learning-dependent LTP. Therefore, in the present study, the effects of propranolol (an antagonist of β-adrenoceptor) and isoproterenol (an agonist of β-adrenoceptor) on extracellular concentrations of glutamate and amplitudes of field excitatory postsynaptic potential were measured in the DG region during active avoidance learning in freely moving conscious rats...
September 4, 2017: Neuroreport
https://www.readbyqxmd.com/read/28866469/l-type-vdccs-participate-in-behavioral-ltp-and-memory-retention
#11
Yuan-Yuan Han, Xiao-Dong Wang, Li Liu, Hong-Mei Guo, Wei Cong, Wen-Wen Yan, Jun-Ni Huang, Peng Xiao, Chu-Hua Li
Although L-type voltage-dependent calcium channels (VDCCs) have been reported to display different even contrary actions on cognitive functions and long-term potentiation (LTP) formation, there is little information regarding the role of L-type VDCCs in behavioral LTP, a learning-induced LTP model, in the intact brain of freely behaving animals. Here we investigated the effects of verapamil, a non-selective blocker of L-type VDCCs, on behavioral LTP and cognitive functions. Population spikes (PS) were recorded by using electrophysiological methods to examine the role of verapamil in behavioral LTP in the hippocampal dentate gyrus (DG) region...
September 1, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28865021/role-of-drebrin-in-synaptic-plasticity
#12
Yuko Sekino, Noriko Koganezawa, Toshiyuki Mizui, Tomoaki Shirao
Synaptic plasticity underlies higher brain function such as learning and memory, and the actin cytoskeleton in dendritic spines composing excitatory postsynaptic sites plays a pivotal role in synaptic plasticity. In this chapter, we review the role of drebrin in the regulation of the actin cytoskeleton during synaptic plasticity, under long-term potentiation (LTP) and long-term depression (LTD). Dendritic spines have two F-actin pools, drebrin-decorated stable F-actin (DF-actin) and drebrin-free dynamic F-actin (FF-actin)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28859215/1-acetoxychavicol-acetate-increases-proteasome-activity-by-activating-camp-pka-signaling
#13
Keisuke Yaku, Isao Matsui-Yuasa, Akiko Kojima-Yuasa
Protein degradation systems are critical pathways for the maintenance of protein homeostasis. The age-dependent attenuation of the proteasome activity contributes to age-related neurodegenerative processes. The molecule 1'-acetoxychavicol acetate (ACA) is naturally obtained from the rhizomes and seeds of Zingiberaceae plants, such as Languas galangal and Alpinia galangal, and exhibits anti-carcinogenic effects. Recently, we have shown that ACA protected the age-related learning and memory impairments in senescence-accelerated mice and maintained cognitive performance...
August 31, 2017: Planta Medica
https://www.readbyqxmd.com/read/28856559/introducing-motivational-interviewing-in-a-sickness-insurance-context-translation-and-implementation-challenges
#14
Christian Ståhl, Maria Gustavsson
Purpose Motivational interviewing (MI) is a conversational method to support clients in need of behavioral change. In an organizational reform, most Swedish sickness insurance officials were trained in MI to promote clients' return to work (RTW) after sick leave. The aim of this article is to investigate experiences of introducing MI as a tool to promote clients' RTW within a sickness insurance context, with special focus on the translation and implementation of the method. Methods A qualitative approach, comprising 69 interviews with officials, managers, and regional coordinators on two occasions...
August 30, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28852913/cancer-patients-intentions-towards-receiving-unsolicited-genetic-information-obtained-using-next-generation-sequencing
#15
Rhodé M Bijlsma, Hester Wessels, Roel H P Wouters, Anne M May, Margreet G E M Ausems, Emile E Voest, Annelien L Bredenoord
Next-generation sequencing (NGS) can be used to generate information about a patient's tumour and personal genome. This powerful diagnostic tool provides solicited and unsolicited hereditary genetic (risk) information that could have consequences for cancer patients and their quality of life. A well-defined approach for returning appropriate genetic risk information is needed in personalized cancer care. A qualitative design with semi-structured interviews was used. We conducted interviews with 24 Dutch patients with different types of cancer, both NGS-experienced and NGS-inexperienced, to learn their intentions, needs and preferences towards receiving unsolicited genetic information obtained using NGS...
August 29, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28843326/valve-interventions-in-utero-understanding-the-timing-indications-and-approaches
#16
REVIEW
Aleksander Sizarov, Younes Boudjemline
Efficient use of fetal echocardiography has enabled early detection of congenital heart disease and of its often irreversible complications, such as ventricular hypoplasia in case of severe stenosis of the semilunar valves. Experience of the past 25 years has proved that balloon dilatation of the severely stenotic or atretic valve in fetuses as early as the 23rd week of gestation is technically feasible with a learning curve. Reported results regarding the ultimate biventricular circulation outcome after fetal valve intervention are at best controversial, with the desired improvements in the quality of life and cost-benefits of the postnatal treatment being as yet unconfirmed...
September 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28839217/re-stepping-into-the-same-river-competition-problem-rather-than-a-reconsolidation-failure-in-an-established-motor-skill
#17
Ella Gabitov, Arnaud Boutin, Basile Pinsard, Nitzan Censor, Stuart M Fogel, Geneviève Albouy, Bradley R King, Habib Benali, Julie Carrier, Leonardo G Cohen, Avi Karni, Julien Doyon
Animal models suggest that consolidated memories return to their labile state when reactivated and need to be restabilized through reconsolidation processes to persist. Consistent with this notion, post-reactivation pharmacological protein synthesis blockage results in mnemonic failure in hippocampus-dependent memories. It has been proposed that, in humans, post-reactivation experience with a competitive task can also interfere with memory restabilization. However, several studies failed to induce performance deficit implementing this approach...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838071/informatics-support-for-basic-research-in-biomedicine
#18
Thomas C Rindflesch, Catherine L Blake, Marcelo Fiszman, Halil Kilicoglu, Graciela Rosemblat, Jodi Schneider, Caroline J Zeiss
Informatics methodologies exploit computer-assisted techniques to help biomedical researchers manage large amounts of information. In this paper, we focus on the biomedical research literature (MEDLINE). We first provide an overview of some text mining techniques that offer assistance in research by identifying biomedical entities (e.g., genes, substances, and diseases) and relations between them in text.We then discuss Semantic MEDLINE, an application that integrates PubMed document retrieval, concept and relation identification, and visualization, thus enabling a user to explore concepts and relations from within a set of retrieved citations...
July 1, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28836810/a-review-of-the-literature-on-pediatric-concussions-and-return-to-learn-rtl-implications-for-rtl-policy-research-and-practice
#19
Jilian A O'Neill, Molly K Cox, Olivio J Clay, James M Johnston, Thomas A Novack, David C Schwebel, Laura E Dreer
OBJECTIVE: While reintegration of concussed youth back into sports has been increasingly studied over the past decade, a noticeably lacking yet growing body of research has begun to focus on issues surrounding return to academics or "return-to-learn" (RTL). The objective of this article was to conduct a comprehensive literature review to identify the full range of themes and gaps in the current body of RTL research. STUDY DESIGN: Researchers analyzed PubMed, PsycINFO, and ERIC databases to identify all recent (January 2000 through May 2016) empirical publications on the RTL process following youth concussions...
August 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28834379/medical-students-views-of-clinical-environments
#20
Ruby Roberts, Jennifer Cleland, Pia Strand, Peter Johnston
BACKGROUND: Monitoring the quality of clinical learning environments (CLEs) is immensely important in medical education. Objective indicators of the quality of the CLE can be used to measure learner perceptions and to inform educational improvements; however, many established tools were not designed for use in clinical settings and are not theoretically grounded. Our aim was to apply a new tool to the new context of a UK setting to explore the perceptions of senior medical students in a number of different CLEs...
August 23, 2017: Clinical Teacher
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