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Chao Xu, Patanjali Ravva, Jun Steve Dang, Johann Laurent, Céline Adessi, Christine McIntyre, Georgina Meneses-Lorente, François Mercier
PURPOSE: To inform lumretuzumab and pertuzumab dose modifications in order to decrease the incidence, severity, and duration of the diarrhea events in metastatic breast cancer patients treated with a combination therapy of lumretuzumab (anti-HER3) in combination with pertuzumab (anti-HER2) and paclitaxel using quantitative clinical pharmacology modeling approaches. METHODS: The safety and pharmacokinetic (PK) data from three clinical trials (lumretuzumab monotherapy n = 47, pertuzumab monotherapy n = 78, and the combination therapy of lumretuzumab, pertuzumab and paclitaxel n = 35) were pooled together to develop a continuous-time discrete states Markov model describing the dynamics of the diarrhea events...
June 18, 2018: Cancer Chemotherapy and Pharmacology
Hélène Seiler, Samuel Palato, Colin Sonnichsen, Harry Baker, Patanjali Kambhampati
The electronic structure of multiexcitons significantly impacts the performance of nanostructures in lasing and light-emitting applications. However, these multiexcitons remain poorly understood due to their complexity arising from many-body physics. Standard transient-absorption and photoluminescence spectroscopies are unable to unambiguously distinguish effects of sample inhomogeneity from exciton-biexciton interactions. Here, we exploit the energy and time resolution of two-dimensional electronic spectroscopy to access the electronic structure of the band-edge biexciton in colloidal CdSe quantum dots...
May 9, 2018: Nano Letters
J Shashi Kiran Reddy, Sisir Roy
No abstract text is available yet for this article.
2018: Frontiers in Psychology
Hélène Seiler, Samuel Palato, Patanjali Kambhampati
Ultrafast coherent multi-dimensional spectroscopies form a powerful set of techniques to unravel complex processes, ranging from light-harvesting, chemical exchange in biological systems to many-body interactions in quantum-confined materials. Yet these spectroscopies remain complex to implement at the high frequencies of vibrational and electronic transitions, thereby limiting their widespread use. Here we demonstrate the feasibility of two-dimensional spectroscopy at optical frequencies in a single beam. Femtosecond optical pulses are spectrally broadened to a relevant bandwidth and subsequently shaped into phase coherent pulse trains...
September 7, 2017: Journal of Chemical Physics
Nitin Gautam, Aditi Sharma, Unjum Bashir, Sisir Rapolu, Nallamilli Mamatha, Siripurapu Sravani
AIM: This study was undertaken to study the effect of three most commonly used dentifrices for denture cleaning and to find out any positive association between number of strokes by toothbrush and surface roughness of acrylic resin. MATERIALS AND METHODS: About 40 acrylic rectangular blocks with high finish were polished until surface roughness was calculated as 0 pirn. The materials tested were distilled water as a control group, Patanjali Dant Kanti, Colgate Total Cream, and Cleansodent as dentifrices...
August 1, 2017: Journal of Contemporary Dental Practice
Robin C Whytock, Elisa Fuentes-Montemayor, Kevin Watts, Patanjaly Barbosa De Andrade, Rory T Whytock, Paul French, Nicholas A Macgregor, Kirsty J Park
Ecosystem function and resilience are compromised when habitats become fragmented due to land-use change. This has led to national and international conservation strategies aimed at restoring habitat extent and improving functional connectivity (i.e., maintaining dispersal processes). However, biodiversity responses to landscape-scale habitat creation and the relative importance of spatial and temporal scales are poorly understood, and there is disagreement over which conservation strategies should be prioritized...
April 2018: Conservation Biology: the Journal of the Society for Conservation Biology
Hélène Seiler, Samuel Palato, Bruno E Schmidt, Patanjali Kambhampati
We report on a setup for coherent multidimensional spectroscopy based on visible continuum generation obtained by propagating 130 fs, <600  μJ pulses centered at 800 nm in a 2.5 m long hollow-core fiber. We find that with these modest input pulse requirements, the fiber can produce a stable, high brightness continuum spanning the 520-900 nm region, moreover in a single propagation step. The fiber exhibits 80% transmission, and the continuum features excellent spatial mode quality. In addition, spectral phase measurements suggest the possibility of a significantly self-compressed output in the visible, which simplifies aspects of the 2D spectrometer...
February 1, 2017: Optics Letters
Ee Siang Choong, George Hruby, Jean Yang, Carol Kwong, Nitya Patanjali
AIM: In prostate cancer, fiducial marker image-guided radiotherapy (FMIGRT) allows correction of setup errors and interfraction physiological motion resulting in improved accuracy of target and sparing of at risk organs. We aim to report outcomes and toxicities observed in patients treated with dose escalation to 78Gy with FMIGRT in our center. METHODS AND MATERIALS: Retrospective review of consecutive patients with histologically confirmed T1-4N0M0 localized prostate cancer treated with dose escalation to 78Gy with FMIGRT in our center...
October 2017: Asia-Pacific Journal of Clinical Oncology
Mahesh Khairnar, Arun Dodamani, G N Karibasappa, Manjiri Deshmukh, Rahul Naik
INTRODUCTION: Very few researches in the past have tried to evaluate the effect of herbal toothpaste on saliva and salivary constituents like alkaline phosphatase and acid phosphatase which play an important role in maintaining oral health. AIM: To evaluate and compare the effect of three different herbal toothpastes on Salivary Alkaline Phosphatase (ALP) and salivary Acid Phosphatase (ACP). MATERIAL AND METHODS: The present study was a preliminary study conducted among 45 dental students (15 subjects in each group) in the age group of 19-21 years...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
S Kemp, R S Allan, N Patanjali, M H Barnett, B P Jonker
We report a unique case of neurological deficit from late onset multiple sclerosis (MS), in a 65-year-old woman, after stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN). At 3.5months post-SRS for TN, the patient developed ataxia and left leg paraesthesiae and brain MRI showed altered signal and enhancement in the vicinity of the right trigeminal root entry zone (REZ). The symptoms remitted following treatment with intravenous methylprednisolone, however, 10months post-SRS, the patient developed gait ataxia and left lower limb weakness...
December 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Shirley Telles, Abhishek K Bhardwaj, Ram K Gupta, Sachin K Sharma, Robin Monro, Acharya Balkrishna
BACKGROUND The present study aimed at determining whether 12 weeks of yoga practice in patients with chronic LBP and MRI-based degenerative changes would result in differences in: (i) self-reported pain, anxiety, and spinal flexibility; and (ii) the structure of the discs or vertebrae. MATERIAL AND METHODS Sixty-two persons with MRI-proven degenerative intervertebral discs (group mean ±S.D., 36.2±6.4 years; 30 females) were randomly assigned to yoga and control groups. However, testing was conducted on only 40 subjects, so only their data are included in this study...
September 13, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Shivarama Varambally, B N Gangadhar
Yoga (derived from 'yuj' which means to yoke together or unite) has been used for millennia as a tool for self-improvement, with the ultimate goal of uniting the individual consciousness with the universal. The physical elements of yoga, although seen as necessary in the path to achieve the goal, they were not considered as the endpoint for a practitioner. Sage Patanjali, who codified the practices into an eight-limbed model (Ashtanga yoga) in the Patanjali Yoga Sutras, makes it clear that the target of yoga is primarily the mind...
June 2016: International Review of Psychiatry
Peter L Bonate, Malidi Ahamadi, Nageshwar Budha, Amparo de la Peña, Justin C Earp, Ying Hong, Mats O Karlsson, Patanjali Ravva, Ana Ruiz-Garcia, Herbert Struemper, Janet R Wade
The purpose of this work was to present a consolidated set of guidelines for the analysis of uncontrolled concomitant medications (ConMed) as a covariate and potential perpetrator in population pharmacokinetic (PopPK) analyses. This white paper is the result of an industry-academia-regulatory collaboration. It is the recommendation of the working group that greater focus be given to the analysis of uncontrolled ConMeds as part of a PopPK analysis of Phase 2/3 data to ensure that the resulting outcome in the PopPK analysis can be viewed as reliable...
April 2016: Journal of Pharmacokinetics and Pharmacodynamics
Michael M Krause, Lakshay Jethi, Timothy G Mack, Patanjali Kambhampati
There are several contradictory accounts of the changes to the emissive behavior of semiconductor nanocrystal upon a ligand exchange from trioctylphosphine/cadmium-phosphonates passivation to N-butylamine. This communication explains the contradictory accounts of this reaction using new insights into ligand chemistry. Also, a previously unknown link between surface emission and cadmium-phosphonate (Z-type) ligands is shown.
November 5, 2015: Journal of Physical Chemistry Letters
Megha Pant, Satyawati Sharma, Saurabh Dubey, Satya Narayan Naik, Phool Kumar Patanjali
The current paper has elaborated the efficient utilization of non-edible oil seed cakes (NEOC), by-products of the bio-diesel extraction process to develop a herbal and novel mosquitocidal composition against the Aedes aegypti larvae. The composition consisted of botanical active ingredients, inerts, burning agents and preservatives; where the botanical active ingredients were karanja (Pongamia glabra) cake powder and jatropha (Jatropha curcas) cake powder, products left after the extraction of oil from karanja and jatropha seed...
March 2016: Journal of Bioscience and Bioengineering
Jonathan Mooney, Patanjali Kambhampati
No abstract text is available yet for this article.
October 16, 2014: Journal of Physical Chemistry Letters
Lakshay Jethi, Michael M Krause, Patanjali Kambhampati
Semiconductor nanocrystals have been synthesized that support intrinsic dual emission from the excitonic core as well as the surface. By virtue of chemical control of the thermodynamics of the core/surface equilibria, these nanocrystals support ratiometric temperature sensing over a broad temperature scale. This surface-chemistry-based approach for creating intrinsic dual emission enables a completely new strategy for application of these nanocrystals in optical nanothermometry.
February 19, 2015: Journal of Physical Chemistry Letters
Klaus B Bærentsen
No abstract text is available yet for this article.
2015: Frontiers in Psychology
Michael M Krause, Patanjali Kambhampati
The intricate chemistry occurring at the surface of semiconductor nanocrystals is crucial to tailoring their optical properties to a myriad of applications. This perspective aims to re-evaluate long held ideas in semiconductor nanocrystal surface science in the light of a body of new and rich research. We start by reviewing recent developments in ligand chemistry, followed by a discussion of spectroscopic and computational approaches used for advancing the poorly-understood electronic structure of the surface...
July 15, 2015: Physical Chemistry Chemical Physics: PCCP
Andrej Bece, Nitya Patanjali, Michael Jackson, May Whitaker, George Hruby
AIMS: To report disease outcomes and late urinary toxicity profile. To assess the impact of changing technique and evolving quality assurance on genitourinary toxicity rates. METHODS AND MATERIALS: One hundred eighty patients were treated with external beam radiation therapy and high-dose-rate brachytherapy (HDRB) for localized intermediate- and high-risk prostate cancer, between December 2002 and February 2012. The HDRB technique evolved over the period of this study, from 19...
September 2015: Brachytherapy
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