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Circulating Progenitor Cells Peripheral Arterial Disease

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https://www.readbyqxmd.com/read/28297574/bioactive-lipids-and-circulating-progenitor-cells-in-patients-with-cardiovascular-disease
#1
Salim S Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K Waller, Arshed A Quyyumi, Ahmed K Abdel-Latif
Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28285391/very-small-embryonic-like-stem-cells-are-mobilized-in-human-peripheral-blood-during-hypoxemic-copd-exacerbations-and-pulmonary-hypertension
#2
Coralie L Guerin, Adeline Blandinières, Benjamin Planquette, Jean-Sébastien Silvestre, Dominique Israel-Biet, Olivier Sanchez, David M Smadja
Very small embryonic-like stem cells (VSELs) are major pluripotent stem cells involved in vascular and tissue regeneration and constitute a recruitable pool of stem/progenitor cells with putative instrumental role in organ repair. Here, we hypothesized that VSELs might be mobilized from the bone marrow (BM) to peripheral blood (PB) in patients with hypoxic lung disease or pulmonary hypertension (PH). The objective of the present study was then to investigate the changes in VSELs number in peripheral blood of patients with hypoxic lung disease and PH...
March 11, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28148896/investigated-the-safety-of-intra-renal-arterial-transfusion-of-autologous-cd34-cells-and-time-courses-of-creatinine-levels-endothelial-dysfunction-biomarkers-and-micro-rnas-in-chronic-kidney-disease-patients-phase-i-clinical-trial
#3
Mel S Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, Hon-Kan Yip
This was a phase I clinical trial to investigate the safety of autologous peripheral-blood-derived CD34+ cell therapy for patients with chronic kidney disease (CKD-treatment) (i.e., at Stages III and IV). Between November 2014 and October 2015, a total of 10 study patients were prospectively enrolled into this phase I trial. Patients who failed to enroll into the trial in the initial state of eligibility assessment were served as CKD-control group (n = 9). The health-control group was composed of 10 volunteers for the purposes of comparing (1) circulation level of endothelial progenitor cells (EPCs), (2) angiogenesis ability, and (3) anti-apoptotic miRNAs between healthy subjects and CKD patients...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/27930695/coordinated-activation-of-vegf-vegfr-2-and-ppar%C3%AE-pathways-by-a-multi-component-chinese-medicine-dhi-accelerated-recovery-from-peripheral-arterial-disease-in-type-2-diabetic-mice
#4
Shuang He, Tiechan Zhao, Hao Guo, Yanzhi Meng, Gangjian Qin, David A Goukassian, Jihong Han, Xuimei Gao, Yan Zhu
Diabetic mellitus (DM) patients are at an increased risk of developing peripheral arterial disease (PAD). Danhong injection (DHI) is a Chinese patent medicine widely used for several cardiovascular indications but the mechanism of action is not well-understood. We investigated the therapeutic potential of DHI on experimental PAD in mice with chemically induced as well as genetic (KKAy) type 2 DM and the overlapping signaling pathways regulating both therapeutic angiogenesis and glucose homeostasis. Compared with normal genetic background wild type (WT) mice, both DM mice showed impaired perfusion recovery in hind-limb ischemia (HLI) model...
2016: PloS One
https://www.readbyqxmd.com/read/27914820/cell-therapy-in-critical-limb-ischemia-a-comprehensive-analysis-of-two-cell-therapy-products
#5
Claire Tournois, Bernard Pignon, Marie-Antoinette Sevestre, Rida Al-Rifai, Valerie Creuza, Gaël Poitevin, Caroline François, Philippe Nguyen
BACKGROUND: Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). In spite of the fact that clinical trials found some efficacy, the mechanism of action remains elusive. The objective of this study was to characterize two autologous cell therapy products (CTPs) obtained from patients with advanced peripheral arterial disease. METHODS: Bone marrow (BM-CTPs) (n = 20) and CTPs obtained by non-mobilized cytapheresis (peripheral blood [PB]-CTPs) (n = 20) were compared...
February 2017: Cytotherapy
https://www.readbyqxmd.com/read/27836295/circulating-osteogenic-endothelial-progenitor-cell-counts-new-biomarker-for-the-severity-of-coronary-artery-disease
#6
Shi-Wei Yang, Rebecca R Hennessy, Sundeep Khosla, Ryan Lennon, Darrell Loeffler, Tao Sun, Zhi Liu, Kyoung-Ha Park, Fei-Long Wang, Lilach O Lerman, Amir Lerman
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27742846/bioactive-lipids-and-circulating-progenitor-cells-in-patients-with-cardiovascular-disease
#7
Salim S Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K Waller, Arshed A Quyyumi, Ahmed K Abdel-Latif
: Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry...
October 14, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27666446/a-depleting-antibody-toward-sca-1-mitigates-a-surge-of-cd34-c-kit-progenitors-and-reduces-vascular-restenosis-in-a-murine-vascular-injury-model
#8
Bryan W Tillman, Jeremy Kelly, Tara D Richards, Alex F Chen, Albert D Donnenberg, Vera S Donnenberg, Edith Tzeng
OBJECTIVE: Vascular restenosis remains a major obstacle to long-term success after vascular intervention. Circulating progenitor cells have been implicated in restenosis, and yet it has remained unclear if these cells, particularly nonendothelial progenitors, have an active role in this pathologic process. We hypothesized that circulating CD34(+)/c-kit(+) progenitors would increase after vascular injury, mirrored by changes in the injury signal, stromal cell-derived factor 1α (sdf1α)...
October 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27596135/circulating-progenitor-cells-and-coronary-microvascular-dysfunction-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-coronary-vascular-dysfunction-study-wise-cvd
#9
Girum Mekonnen, Salim S Hayek, Puja K Mehta, Qunna Li, Ernestine Mahar, Liping Mou, Tanya S Kenkre, John W Petersen, Babak Azarbal, Bruce Samuels, R David Anderson, Tara Sedlak, Melody Zaya, Megha Agarwal, Afsaneh Haftbaradaran, Margo Minissian, Eileen Handberg, Carl J Pepine, Christopher R Cogle, C Noel Bairey Merz, Edmund K Waller, Arshed A Quyyumi
BACKGROUND AND AIMS: Ischemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs). We hypothesized that women with chronic myocardial ischemia from coronary microvascular disease (CMD) will mobilize CPCs. METHODS: In 123 women with ischemic symptoms and signs but no obstructive coronary artery disease (CAD) enrolled in the Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD), we measured coronary flow reserve (CFR) in response to intracoronary adenosine...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27451462/plasma-levels-of-proprotein-convertase-subtilisin-kexin-type-9-are-elevated-in-patients-with-peripheral-artery-disease-and-associated-with-metabolic-disorders-and-dysfunction-in-circulating-progenitor-cells
#10
(no author information available yet)
No abstract text is available yet for this article.
July 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27447811/association-of-cd34-cd133-vegfr2-positive-cell-numbers-with-eicosapentaenoic-acid-and-postprandial-hyperglycemia-in-patients-with-coronary-artery-disease
#11
Tetsuji Morishita, Hiroyasu Uzui, Hiroyuki Ikeda, Naoki Amaya, Kenichi Kaseno, Kentaro Ishida, Yoshitomo Fukuoka, Jong-Dae Lee, Hiroshi Tada
OBJECTIVES: Circulating endothelial progenitor cells (EPCs), which have the ability to differentiate into mature endothelial cells, can elicit angiogenesis, vasculogenesis and vessel repair in cardiac ischemia and vascular injuries caused by endothelial damage. Serum 1,5-anhydro-d-glucitol (1,5-AG), which is a useful clinical marker of postprandial hyperglycemia, eicosapentaenoic acid (EPA), and arachidonic acid (AA) are newly identified risk factors for coronary artery disease (CAD)...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27267067/circulating-progenitor-cells-identify-peripheral-arterial-disease-in-patients-with-coronary-artery-disease
#12
Salim S Hayek, James MacNamara, Ayman S Tahhan, Mosaab Awad, Adithya Yadalam, Yi-An Ko, Sean Healy, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Salman S Sher, Nima Ghasemzadeh, Riyaz Patel, Jinhee Kim, Edmund K Waller, Arshed A Quyyumi
RATIONALE: Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% of patients with coronary artery disease (CAD) develop PAD. Decline in the number of bone marrow-derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown. OBJECTIVE: Determine whether differences exist in PCs counts of CAD patients with and without known PAD...
August 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27207972/plasma-levels-of-proprotein-convertase-subtilisin-kexin-type-9-are-elevated-in-patients-with-peripheral-artery-disease-and-associated-with-metabolic-disorders-and-dysfunction-in-circulating-progenitor-cells
#13
Ting-Hsing Chao, I-Chih Chen, Yi-Heng Li, Po-Tseng Lee, Shih-Ya Tseng
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with the presence and severity of peripheral artery disease (PAD) and with parameters of endothelial homeostasis. METHODS AND RESULTS: A post hoc analysis of 2 randomized trials (115 patients, 44 with PAD and 71 without atherosclerotic disease) was conducted. Patients with PAD had significantly higher plasma PCSK9 levels than those without (471...
May 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26511986/endothelial-progenitor-cells-as-a-biological-marker-of-peripheral-artery-disease
#14
Lukas Bitterli, Samuel Afan, Stephan Bühler, Stefano DiSanto, Marcel Zwahlen, Kurt Schmidlin, Zijang Yang, Iris Baumgartner, Nicolas Diehm, Christoph Kalka
The role of endothelial progenitor cells (EPCs) in peripheral artery disease (PAD) remains unclear. We hypothesized that EPC mobilization and function play a central role in the development of endothelial dysfunction and directly influence the degree of atherosclerotic burden in peripheral artery vessels. The number of circulating EPCs, defined as CD34(+)/KDR(+) cells, were assessed by flow cytometry in 91 subjects classified according to a predefined sample size of 31 non-diabetic PAD patients, 30 diabetic PAD patients, and 30 healthy volunteers...
February 2016: Vascular Medicine
https://www.readbyqxmd.com/read/26451256/determination-of-early-and-late-endothelial-progenitor-cells-in-peripheral-circulation-and-their-clinical-association-with-coronary-artery-disease
#15
Shotoku Tagawa, Chiaki Nakanishi, Masayuki Mori, Tsuyoshi Yoshimuta, Shohei Yoshida, Masaya Shimojima, Junichiro Yokawa, Masa-Aki Kawashiri, Masakazu Yamagishi, Kenshi Hayashi
The clinical implications of early and late endothelial progenitor cells (EPCs) in coronary artery disease (CAD) remain unclear. We investigated endothelial dysfunction in CAD by simultaneously examining early and late EPC colony formation and gene expression of specific surface markers in EPCs. EPCs were extracted from a total of 83 subjects with (n = 47) and without (n = 36) CAD. Early and late EPC colonies were formed from mononuclear cells extracted from peripheral blood. We found that fewer early EPC colonies were produced in the CAD group (7...
2015: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/26324152/ischemia-related-changes-in-circulating-stem-and-progenitor-cells-and-associated-clinical-characteristics-in-peripheral-artery-disease
#16
Rana Saber, Kiang Liu, Luigi Ferrucci, Michael H Criqui, Lihui Zhao, Lu Tian, Jack M Guralnik, Yihua Liao, Kathryn Domanchuk, Melina R Kibbe, David Green, Harris Perlman, Mary M McDermott
The extent and clinical significance of stem and progenitor cell (SPC) increases in response to lower-extremity ischemia in people with peripheral artery disease (PAD) are unclear. We compared changes in SPC levels immediately following a treadmill exercise test between individuals with and without PAD. Among participants with PAD, we determined whether more severe PAD was associated with greater increases in SPCs following treadmill exercise-induced lower-extremity ischemia. We measured SPC levels in 25 participants with PAD and 20 without PAD before and immediately after a treadmill exercise test...
December 2015: Vascular Medicine
https://www.readbyqxmd.com/read/26276790/impaired-vascular-function-and-repair-in-patients-with-premature-coronary-artery-disease
#17
Mairi Brittan, Amanda Hunter, Mounia Boulberdaa, Takeshi Fujisawa, Elizabeth M Skinner, Anoop Sv Shah, Andrew H Baker, Nicholas L Mills
BACKGROUND: Endothelial dysfunction is central to the pathogenesis of coronary artery disease, but the role of local and circulating endothelial progenitor cells in maintaining vascular health is poorly understood. We hypothesised that impaired local and circulating vascular repair mechanisms predispose to endothelial dysfunction and the premature onset of coronary artery disease. METHODS AND RESULTS: Patients with premature coronary artery disease (n = 16) and healthy age- and sex-matched controls (n = 16) underwent venous occlusion plethysmography with intra-arterial infusion of acetylcholine and sodium nitroprusside...
December 2015: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/26241902/vitamin-d-status-in-rheumatoid-arthritis-inflammation-arterial-stiffness-and-circulating-progenitor-cell-number
#18
Alberto Lo Gullo, Giuseppe Mandraffino, Gianluca Bagnato, Caterina Oriana Aragona, Egidio Imbalzano, Angela D'Ascola, Francesco Rotondo, Antonella Cinquegrani, Enricomaria Mormina, Carlo Saitta, Antonio Giovanni Versace, Maria Adriana Sardo, Renato Lo Gullo, Saverio Loddo, Antonino Saitta
BACKGROUND AND AIMS: Suboptimal vitamin D status was recently acknowledged as an independent predictor of cardiovascular diseases and all-cause mortality in several clinical settings, and its serum levels are commonly reduced in Rheumatoid Arthritis (RA). Patients affected by RA present accelerated atherosclerosis and increased cardiovascular morbidity and mortality with respect to the general population. In RA, it has been reported an impairment of the number and the activity of circulating proangiogenic haematopoietic cells (PHCs), including CD34+, that may play a role in endothelial homeostasis...
2015: PloS One
https://www.readbyqxmd.com/read/26206680/the-role-of-synthetic-extracellular-matrices-in-endothelial-progenitor-cell-homing-for-treatment-of-vascular-disease
#19
REVIEW
Priscilla A Williams, Eduardo A Silva
Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment of endothelial progenitor cells (EPCs). This mobilization and homing is a multi-step process involving EPC detachment from their steady state bone marrow niches, entry into circulation, rolling along vessel endothelium, transmigration, and adhesion to denuded extracellular matrix (ECM) where they may participate in neovessel formation...
October 2015: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/25874380/circulating-endothelial-progenitor-cells-and-the-risk-of-vascular-events-after-ischemic-stroke
#20
Joan Martí-Fàbregas, Raquel Delgado-Mederos, Javier Crespo, Esther Peña, Rebeca Marín, Elena Jiménez-Xarrié, Ana Fernández-Arcos, Jesús Pérez-Pérez, Alejandro Martínez-Domeño, Pol Camps-Renom, Luís Prats-Sánchez, Francesca Casoni, Lina Badimon
BACKGROUND AND PURPOSE: We evaluated the hypothesis that the number of circulating EPC could be associated with the risk of stroke recurrence (SR) or vascular events (VE) after an ischemic stroke. METHODS: We studied prospectively consecutive patients with cerebral infarction within the first 48 hours after the onset. We recorded demographic factors, vascular risk factors, previous Rankin scale (RS) score, and etiology. We analyzed EPC counts by flow cytometry in blood collected at day 7 and defined EPC as CD34+/CD133+/KDR+ cells...
2015: PloS One
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