Lucia Beltran-Camacho, Margarita Jimenez-Palomares, Marta Rojas-Torres, Ismael Sanchez-Gomar, Antonio Rosal-Vela, Sara Eslava-Alcon, Mª Carmen Perez-Segura, Ana Serrano, Borja Antequera-González, Jose Angel Alonso-Piñero, Almudena González-Rovira, Mª Jesús Extremera-García, Manuel Rodriguez-Piñero, Rafael Moreno-Luna, Martin Røssel Larsen, Mª Carmen Durán-Ruiz
BACKGROUND: Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or extremities, with a high risk of mortality due to associated comorbidities. Circulating angiogenic cells (CACs), also known as early endothelial progenitor cells, constitute promising candidates for cell therapy in CLI due to their assigned vascular regenerative properties...
March 6, 2020: Stem Cell Research & Therapy