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Denervated muscle stimulation

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https://www.readbyqxmd.com/read/27836905/electrophysiological-study-of-femoral-nerve-function-after-a-continuous-femoral-nerve-block-for-anterior-cruciate-ligament-reconstruction-a-randomized-controlled-single-blind-trial
#1
Kevin Stebler, Robin Martin, Kyle Robert Kirkham, Thierry Küntzer, Istvan Bathory, Eric Albrecht
BACKGROUND: A continuous femoral nerve block (CFNB) is an effective analgesic treatment after anterior cruciate ligament (ACL) reconstruction but may result in transient femoral nerve injuries and quadriceps muscle weakness, which in turn contribute to worsened functional outcomes. PURPOSE: To compare electrophysiological criteria of a femoral nerve injury as well as functional and pain-related outcomes after ACL reconstruction when analgesia was provided by a CFNB or intravenous patient-controlled analgesic of morphine (IV PCA)...
November 11, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27796305/monitoring-peripheral-nerve-degeneration-in-als-by-label-free-stimulated-raman-scattering-imaging
#2
Feng Tian, Wenlong Yang, Daniel A Mordes, Jin-Yuan Wang, Johnny S Salameh, Joanie Mok, Jeannie Chew, Aarti Sharma, Ester Leno-Duran, Satomi Suzuki-Uematsu, Naoki Suzuki, Steve S Han, Fa-Ke Lu, Minbiao Ji, Rosanna Zhang, Yue Liu, Jack Strominger, Neil A Shneider, Leonard Petrucelli, X Sunney Xie, Kevin Eggan
The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be facilitated if motor axon degeneration could be more readily visualized. Here we demonstrate that stimulated Raman scattering (SRS) microscopy could be used to sensitively monitor peripheral nerve degeneration in ALS mouse models and ALS autopsy materials. Three-dimensional imaging of pre-symptomatic SOD1 mouse models and data processing by a correlation-based algorithm revealed that significant degeneration of peripheral nerves could be detected coincidentally with the earliest detectable signs of muscle denervation and preceded physiologically measurable motor function decline...
October 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27593485/nerve-and-free-gracilis-muscle-transfers-for%C3%A2-thumb-and-finger-extension-reconstruction-in-long-standing-tetraplegia
#3
Jayme Augusto Bertelli, Marcos Flávio Ghizoni
PURPOSE: With spinal cord injuries, muscles below the level of the lesion remain innervated despite the absence of volitional control. This persistent innervation protects against denervation atrophy and may allow for nerve transfers to treat long-standing lesions within the spinal cord. We tested the hypothesis that in chronic spinal cord lesions, muscles remained viable for reinnervation. METHODS: To test this hypothesis, we operated on 7 patients with tetraplegia to reconstruct thumb and finger extension after a mean interval of 5 years since injury...
September 1, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27592133/recovery-from-muscle-weakness-by-exercise-and-fes-lessons-from-masters-active-or-sedentary-seniors-and-sci-patients
#4
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Kyle Edmunds, Íris Dröfn Árnadóttir, Sandra Zampieri, Barbara Ravara, Francesco Gava, Alessandra Nori, Valerio Gobbo, Stefano Masiero, Andrea Marcante, Alfonc Baba, Francesco Piccione, Sheila Schils, Amber Pond, Simone Mosole
Many factors contribute to the decline of skeletal muscle that occurs as we age. This is a reality that we may combat, but not prevent because it is written into our genome. The series of records from World Master Athletes reveals that skeletal muscle power begins to decline at the age of 30 years and continues, almost linearly, to zero at the age of 110 years. Here we discuss evidence that denervation contributes to the atrophy and slowness of aged muscle. We compared muscle from lifelong active seniors to that of sedentary elderly people and found that the sportsmen have more muscle bulk and slow fiber type groupings, providing evidence that physical activity maintains slow motoneurons which reinnervate muscle fibers...
September 3, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27584138/electrical-stimulation-based-on-chronaxie-increases-fibrosis-and-modulates-tweak-fn14-tgf-%C3%AE-myostatin-and-mmp-pathways-in-denervated-muscles
#5
Clara Maria Pinheiro-Dardis, Thiago Luiz Russo
OBJECTIVE: The aim of this work was to investigate the effects of electrical stimulation (ES) of denervated muscles of rat in neuromuscular performance, muscle atrophy, and fibrosis formation. DESIGN: Wistar rats were divided into normal (N), 7- or 15-day denervation (D7d and D15d), D7d or D15d plus ES (DES7d and DES15d, respectively). Sciatic nerves were crushed causing muscle denervation. Two hundred muscle contractions were electrically induced daily by surface electrodes, considering muscle chronaxie...
August 31, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27513942/denervation-induced-activation-of-the-ubiquitin-proteasome-system-reduces-skeletal-muscle-quantity-not-quality
#6
Cory W Baumann, Haiming M Liu, LaDora V Thompson
It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity). However, it is currently unknown whether activation of this pathway also affects function by impairing the muscle's intrinsic ability to produce force (i.e., quality). Therefore, the purpose of this study was twofold, (1) document how the ubiquitin-proteasome system responds to denervation and (2) identify the physiological consequences of these changes...
2016: PloS One
https://www.readbyqxmd.com/read/27464347/evidence-for-dying-back-axonal-degeneration-in-age-associated-skeletal-muscle-decline
#7
Tae Chung, Jae Sung Park, Sangri Kim, Nataly Montes, Jeremy Walston, Ahmet Höke
INTRODUCTION: Age-associated muscle strength decline is a major contributing factor to increased late life functional decline and co-morbidity, and is strongly associated with early mortality. Although all parts of the neuromuscular system seem to be affected by aging, dying-back of motor axons likely plays a major role. METHODS: We compared the degeneration in ventral roots and NMJ denervation in young and aged mice and correlated the findings with strength and electrophysiological measures...
July 27, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27229174/enhanced-flexible-tubular-microelectrode-with-conducting-polymer-for-multi-functional-implantable-tissue-machine-interface
#8
Hong-Chang Tian, Jing-Quan Liu, Xiao-Yang Kang, Long-Jun Tang, Ming-Hao Wang, Bo-Wen Ji, Bin Yang, Xiao-Lin Wang, Xiang Chen, Chun-Sheng Yang
Implantable biomedical microdevices enable the restoration of body function and improvement of health condition. As the interface between artificial machines and natural tissue, various kinds of microelectrodes with high density and tiny size were developed to undertake precise and complex medical tasks through electrical stimulation and electrophysiological recording. However, if only the electrical interaction existed between electrodes and muscle or nerve tissue without nutrition factor delivery, it would eventually lead to a significant symptom of denervation-induced skeletal muscle atrophy...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27138280/moderate-modulation-of-disease-in-the-g93a-model-of-als-by-the-compound-2-2-hydroxyphenyl-benzoxazole-hbx
#9
Teresa M Evans, Arunabh Bhattacharya, Yun Shi, Wenbo Qi, Travis J Block, Asish Chaudhuri, Alakananda Ray Chaudhuri, Kara Hawker, Holly Van Remmen
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease characterized by degeneration and death of motor neurons. Aberrant protein aggregation and oxidative stress are implicated in the etiology of ALS; thus preventing propagation of early aggregation events and oxidative damage could be an effective therapy. We tested the effect of dietary supplementation (initiated 40 days of age) with 2-(2-hydroxyphenyl)-benzoxazole (HBX), a compound with metal chelator and anti-aggregation properties, on disease onset, progression and lifespan in the G93A mouse model of ALS...
June 15, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27136709/amp-activated-kinase-%C3%AE-2-deficiency-protects-mice-from-denervation-induced-skeletal-muscle-atrophy
#10
Yuting Guo, Jin Meng, Yinglong Tang, Ting Wang, Bin Wei, Run Feng, Bing Gong, Huiwen Wang, Guangju Ji, Zhongbing Lu
AMP-activated protein kinase (AMPK) is a master regulator of skeletal muscle metabolic pathways. Recently, AMPK activation by AICAR has been shown to increase myofibrillar protein degradation in C2C12 myotubes via stimulating autophagy and ubiquitin proteasome system. However, the impact of AMPKα on denervation induced muscle atrophy has not been tested. In this study, we performed sciatic denervation on hind limb muscles in both wild type (WT) and AMPKα2(-/-) mice. We found that AMPKα was phosphorylated in atrophic muscles following denervation...
June 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27126558/inhibition-of-the-pontine-k%C3%A3-lliker-fuse-nucleus-reduces-genioglossal-activity-elicited-by-stimulation-of-the-retrotrapezoid-chemoreceptor-neurons
#11
Josiane N Silva, Elvis V Lucena, Talita M Silva, Rosélia S Damasceno, Ana C Takakura, Thiago S Moreira
The Kölliker-Fuse (KF) region, located in the dorsolateral pons, projects to several brainstem areas involved in respiratory regulation, including the chemoreceptor neurons within the retrotrapezoid nucleus (RTN). Several lines of evidence indicate that the pontine KF region plays an important role in the control of the upper airways for the maintenance of appropriate airflow to and from the lungs. Specifically, we hypothesized that the KF region is involved in mediating the response of the hypoglossal motor activity to central respiratory chemoreflex activation and to stimulation of the chemoreceptor neurons within the RTN region...
July 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27123252/interaction-between-muscle-and-bone-and-improving-the-effects-of-electrical-muscle-stimulation-on-amyotrophy-and-bone-loss-in-a-denervation-rat-model-via-sciatic-neurectomy
#12
B O Feng, Wei Wu, Hua Wang, Junchen Wang, Dongya Huang, Ling Cheng
The side-to-side difference in bone mineral content and soft tissue composition of extremities and their associations have been observed in patients with stroke and the results are inconsistent. The aim of the present study was to investigate the interaction between bone mineral content (BMC), lean mass (LM) and fat mass (FM) in the paretic extremities in patients following stroke and to determine the effectiveness of electrical muscle stimulation (EMS) following sciatic neurectomy (SN) in rats. BMC, LM and FM were measured by dual-energy X-ray absorptiometry in 61 hemiplegic patients following stroke...
May 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27059940/melatonin-behavior-in-restoring-chemical-damaged-c2c12-myoblasts
#13
Sara Salucci, Valentina Baldassarri, Barbara Canonico, Sabrina Burattini, Michela Battistelli, Michele Guescini, Stefano Papa, Vilberto Stocchi, Elisabetta Falcieri
It is known that, besides a wide range of functions, melatonin provides protection against oxidative stress, thanks to its ability to act, directly, as a free radical scavenger and, indirectly, by stimulating antioxidant enzymes production and mitochondrial electron transport chain efficiency. Oxidative stress is one of the major players in initiating apoptotic cell death in skeletal muscle, as well as in other tissues. Apoptosis is essential for skeletal muscle development and homeostasis; nevertheless, its misregulation has been frequently observed in several myopathies, in sarcopenia, as well as in denervation and disuse...
June 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/26913160/biology-of-muscle-atrophy-and-of-its-recovery-by-fes-in-aging-and-mobility-impairments-roots-and-by-products
#14
REVIEW
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Simone Mosole, Sandra Zampieri, Valerio Gobbo, Barbara Ravara, Francesco Piccione, Andrea Marcante, Alfonc Baba, Sheila Schils, Amber Pond, Francesco Gava
There is something in our genome that dictates life expectancy and there is nothing that can be done to avoid this; indeed, there is not yet any record of a person who has cheated death. Our physical prowess can vacillate substantially in our lifetime according to our activity levels and nutritional status and we may fight aging, but we will inevitably lose. We have presented strong evidence that the atrophy which accompanies aging is to some extent caused by loss of innervation. We compared muscle biopsies of sedentary seniors to those of life long active seniors, and show that these groups indeed have a different distribution of muscle fiber diameter and fiber type...
August 24, 2015: European Journal of Translational Myology
https://www.readbyqxmd.com/read/26913154/3d-false-color-computed-tomography-for-diagnosis-and-follow-up-of-permanent-denervated-human-muscles-submitted-to-home-based-functional-electrical-stimulation
#15
REVIEW
Ugo Carraro, Kyle J Edmunds, Paolo Gargiulo
This report outlines the use of a customized false-color 3D computed tomography (CT) protocol for the imaging of the rectus femoris of spinal cord injury (SCI) patients suffering from complete and permanent denervation, as characterized by complete Conus and Cauda Equina syndrome. This muscle imaging method elicits the progression of the syndrome from initial atrophy to eventual degeneration, as well as the extent to which patients' quadriceps could be recovered during four years of home-based functional electrical stimulation (h-b FES)...
March 11, 2015: European Journal of Translational Myology
https://www.readbyqxmd.com/read/26913151/functional-electrical-stimulation-as-a-safe-and-effective-treatment-for-equine-epaxial-muscle-spasms-clinical-evaluations-and-histochemical-morphometry-of-mitochondria-in-muscle-biopsies
#16
Barbara Ravara, Valerio Gobbo, Ugo Carraro, Lin Gelbmann, Jamie Pribyl, Sheila Schils
Functional Electrical Stimulation (FES) has been used extensively over several decades to reverse muscle atrophy during rehabilitation for spinal cord injury patients. The benefits of the technology are being expanded into other areas, and FES has been recently utilized for injury rehabilitation and performance enhancement in horses. Six retired horses (age from 10 to 17 yrs) that had been previously used mainly for dressage riding were selected for this study. Clinical evaluation found epaxial muscle spasms in all horses with minimal to no pelvic extension when manually palpated...
March 11, 2015: European Journal of Translational Myology
https://www.readbyqxmd.com/read/26913148/persistent-muscle-fiber-regeneration-in-long-term-denervation-past-present-future
#17
REVIEW
Ugo Carraro, Simona Boncompagni, Valerio Gobbo, Katia Rossini, Sandra Zampieri, Simone Mosole, Barbara Ravara, Alessandra Nori, Roberto Stramare, Francesco Ambrosio, Francesco Piccione, Stefano Masiero, Vincenzo Vindigni, Paolo Gargiulo, Feliciano Protasi, Helmut Kern, Amber Pond, Andrea Marcante
Despite the ravages of long term denervation there is structural and ultrastructural evidence for survival of muscle fibers in mammals, with some fibers surviving at least ten months in rodents and 3-6 years in humans. Further, in rodents there is evidence that muscle fibers may regenerate even after repeated damage in the absence of the nerve, and that this potential is maintained for several months after denervation. While in animal models permanently denervated muscle sooner or later loses the ability to contract, the muscles may maintain their size and ability to function if electrically stimulated soon after denervation...
March 11, 2015: European Journal of Translational Myology
https://www.readbyqxmd.com/read/26784276/ventilation-limits-aerobic-capacity-after-functional-electrical-stimulation-row-training-in-high-spinal-cord-injury
#18
Shuang Qiu, Saeed Alzhab, Glen Picard, J Andrew Taylor
PURPOSE: In the able-bodied, exercise training results in increased ventilatory capacity to meet increased aerobic demands of trained skeletal muscle. However, after spinal cord injury (SCI), peak ventilation can be limited by pulmonary muscle denervation. In fact, peak ventilation may restrict aerobic capacity in direct relation to injury level. Hybrid functional electrical stimulation (FES) exercise training results in increased aerobic capacity and dissociation between aerobic capacity and injury level in those with injuries at T3 and below...
June 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/26768433/chronic-refractory-myofascial-pain-and-denervation-supersensitivity-as-global-public-health-disease
#19
J Chu, F Bruyninckx, D V Neuhauser
Chronic pain with a 30.3% global prevalence significantly impacts universal health. Low back pain has a 9.4% prevalence worldwide causing the most widespread disability. Neck pain ranks 4th highest regarding years lived with disability with a 4.9% prevalence worldwide. The principal cause of pain in 85% of patients visiting a tertiary pain clinic has a myofascial origin. The root cause is multifocal neuromuscular ischaemia at myofascial trigger points from muscle tightening and shortening following spondylotic radiculopathy induced partial denervation...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26692833/delayed-peripheral-nerve-repair-methods-including-surgical-cross-bridging-to-promote-nerve-regeneration
#20
REVIEW
Tessa Gordon, Placheta Eva, Gregory H Borschel
Despite the capacity of Schwann cells to support peripheral nerve regeneration, functional recovery after nerve injuries is frequently poor, especially for proximal injuries that require regenerating axons to grow over long distances to reinnervate distal targets. Nerve transfers, where small fascicles from an adjacent intact nerve are coapted to the nerve stump of a nearby denervated muscle, allow for functional return but at the expense of reduced numbers of innervating nerves. A 1-hour period of 20 Hz electrical nerve stimulation via electrodes proximal to an injury site accelerates axon outgrowth to hasten target reinnervation in rats and humans, even after delayed surgery...
October 2015: Neural Regeneration Research
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