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https://www.readbyqxmd.com/read/29626364/elevated-expression-of-keratin-17-in-oropharyngeal-squamous-cell-carcinoma-is-associated-with-decreased-survival
#1
Elliot Regenbogen, Michelle Mo, Jamie Romeiser, A Laurie W Shroyer, Luisa F Escobar-Hoyos, Stephanie Burke, Kenneth R Shroyer
BACKGROUND: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. METHODS: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa...
April 6, 2018: Head & Neck
https://www.readbyqxmd.com/read/29599009/incremental-prognostic-value-of-apparent-diffusion-coefficient-histogram-analysis-in-head-and-neck-squamous-cell-carcinoma
#2
Xiaoxia Li, Ying Yuan, Jiliang Ren, Yiqian Shi, Xiaofeng Tao
RATIONALE AND OBJECTIVES: We aimed to investigate the incremental prognostic value of apparent diffusion coefficient (ADC) histogram analysis in patients with head and neck squamous cell carcinoma (HNSCC) and integrate it into a multivariate prognostic model. MATERIALS AND METHODS: A retrospective review of magnetic resonance imaging findings was conducted in patients with pathologically confirmed HNSCC between June 2012 and December 2015. For each tumor, six histogram parameters were derived: the 10th, 50th, and 90th percentiles of ADC (ADC10 , ADC50 , and ADC90 ); mean ADC values (ADCmean ); kurtosis; and skewness...
March 26, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29594214/sdf-1-cxcr4-expression-in-head-and-neck-cancer-and-outcome-after-postoperative-radiochemotherapy
#3
Chiara De-Colle, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Christine Bayer, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips, Apostolos Menegakis
Introduction: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches. Preclinical and first clinical observations showed that the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12) play an important role in tumour cell proliferation, survival, cancer progression, metastasis and treatment resistance...
August 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29581773/epigenetic-modification-of-sall1-as-a-novel-biomarker-for-the-prognosis-of-early-stage-head-and-neck-cancer
#4
Kiyoshi Misawa, Yuki Misawa, Atsushi Imai, Daiki Mochizuki, Shiori Endo, Masato Mima, Ryuji Ishikawa, Hideya Kawasaki, Takashi Yamatodani, Takeharu Kanazawa
This study examined Sal-like protein ( SALL)1 methylation profiles in head and neck squamous-cell carcinoma (HNSCC) patients at diagnosis and follow-up, and evaluated their prognostic significance and value as a biomarker. SALL1 expression was examined in a panel of cell lines by quantitative reverse transcription PCR (qRT-PCR). Promoter methylation was determined by quantitative methylation-specific polymerase chain reaction (qMSP) and was compared to the clinical characteristics of 205 samples. SALL1 promoter methylation was associated with transcriptional inhibition and was correlated with disease recurrence in 31...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29578359/approach-to-oligometastatic-disease-in-head-and-neck-cancer-on-behalf-of-the-gortec
#5
Xu Shan Sun, Cécile Michel, Emmanuel Babin, Dominique De Raucourt, Adeline Péchery, Elisabeta Gherga, Bernard Géry, Carmen Florescu, Jean Bourhis, Juliette Thariat
Median survival for recurrent/metastatic head and neck squamous cell cancer (HNSCC) patients is about 10 months after first-line best systemic treatment. We aimed to assess current approaches of oligometastatic HNSCC patients by the analysis of current concept and published data (1995-2017) in this population. Five-year survival rates are over 20% in selected patients who undergo metastasis-directed therapy by either surgery or stereotactic irradiation. Human papillomavirus(+) HNSCC patients have more disseminated metastases but respond more favorably and also benefit from ablative treatments...
March 26, 2018: Future Oncology
https://www.readbyqxmd.com/read/29569374/overexpression-of-wdr5-associates-with-aggressive-clinicopathological-features-and-unfavorable-prognosis-in-head-neck-squamous-cell-carcinoma
#6
Yaping Wu, Pengfei Diao, Zhongwu Li, Wei Zhang, Dongmiao Wang, Yanling Wang, Jie Cheng
BACKGROUND: WD repeat domain 5 (WDR5), a core member of Mixed lineage leukemia (MLL) and SET1 histone H3 lysine 4 (H3K4) methyltransferase complexes, is involved in multiple biological and pathological processes. Its deregulation in cancer and pro-tumorigenic roles have been increasingly appreciated. However, the expression pattern of WDR5 and its biological functions in head neck squamous cell carcinoma (HNSCC) have not been well established. METHODS: The expression of WDR5 mRNA in HNSCC was determined by data mining and interrogation using publicly available databases...
March 22, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29560108/the-aurora-kinase-a-phe31-ile-polymorphism-as-possible-predictor-of-response-to-treatment-in-head-and-neck-squamous-cell-carcinoma
#7
Alexander Baumann, Anna Maria S Buchberger, Guido Piontek, Dominik Schüttler, Martina Rudelius, Rudolf Reiter, Lena Gebel, Gerhard Piendl, Gero Brockhoff, Anja Pickhard
Recently the Aurora-Kinases (Aurk) moved into the focus as novel disease related biomarkers and therapeutic targets. Elevated Aurora-Kinase expression has been found in a number of malignancies, amongst them HNSCC. For esophageal cancer, the AurkA Phe31-Ile polymorphism has previously been associated with tumor progression. Here we evaluated the treatment efficiency of HNSCC cell radiation as a function of Aurora-Kinases in HNSCC cell lines. Moreover, we investigated a potential sensitization to radiation by a cell treatment with the inhibitors Alisertib, Barasertib, Docetaxel and VX-680...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29542214/circulating-tumor-dna-as-a-biomarker-and-liquid-biopsy-in-head-and-neck-squamous-cell-carcinoma
#8
Karl Payne, Rachel Spruce, Andrew Beggs, Neil Sharma, Anthony Kong, Timothy Martin, Satyesh Parmar, Prav Praveen, Paul Nankivell, Hisham Mehanna
The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).
March 15, 2018: Head & Neck
https://www.readbyqxmd.com/read/29541402/semaphorin-4d-in-human-head-and-neck-cancer-tissue-and-peripheral-blood-a-dense-fibrotic-peri-tumoral-stromal-phenotype
#9
Roshanak Derakhshandeh, Sonia Sanadhya, Kyu Lee Han, Haiyan Chen, Olga Goloubeva, Tonya J Webb, Rania H Younis
The search for stromal biomarkers in carcinoma patients is a challenge in the field. Semaphorin 4D (Sema4D), known for its various developmental, physiological and pathological effects, plays a role in pro and anti-inflammatory responses. It is expressed in many epithelial tumors including head and neck squamous cell carcinoma (HNSCC). Recently, we found that HNSCC-associated Sema4D modulates an immune-suppressive, tumor-permissible environment by inducing the expansion of myeloid derived suppressor cells. The purpose of this study was to determine the value of Sema4D as a biomarker for the peri-tumoral stromal phenotype in human HNSCC...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29530934/lipidomic-profiling-links-the-fanconi-anemia-pathway-to-glycosphingolipid-metabolism-in-head-and-neck-cancer-cells
#10
Xueheng Zhao, Marion G Brusadelli, Sharon L Sauter, Melinda Butsch Kovacic, Wujuan Zhang, Lindsey E Romick-Rosendale, Paul F Lambert, Kenneth D Setchell, Susanne I Wells
PURPOSE: Mutations in Fanconi anemia (FA) genes are common in sporadic squamous cell carcinoma of the head and neck (HNSCC) and we have previously demonstrated that FA pathway depletion in HNSCC cell lines stimulates invasion. The goal of our studies was to use a systems approach in order to define FA pathway-dependent lipid metabolism, and to extract lipid-based signatures and effectors of invasion in FA-deficient cells. EXPERIMENTAL DESIGN: We subjected FA-isogenic HNSCC keratinocyte cell lines to untargeted and targeted lipidomics analyses to discover novel biomarkers and candidate therapeutic targets in FA-deficient cells...
March 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29516932/evaluation-of-serum-levels-of-oxidized-and-reduced-glutathione-and-total-antioxidant-capacity-in-patients-with-head-and-neck-squamous-cell-carcinoma
#11
Atessa Pakfetrat, Zohreh Dalirsani, Seyed Issac Hashemy, Ala Ghazi, Leyla Vazifeh Mostaan, Kazem Anvari, Atekeh Movaghari Pour
Background and Aim: Squamous cell carcinoma (SCC) is the most common type of oral cancer, and it is important for it to be diagnosed in early stages. Researchers are interested in exploring the possibility of using biomarkers in the diagnosis of SCC in early stages. One of the detectable biomarkers in the serum is glutathione. Glutathione includes two forms: reduced form (or GSH) and oxidized form (or GSSG). The GSH/GSSG ratio tends to decrease in severe oxidative stress. The aim of this study was to assess the serum levels of GSH and GSSG as well as GSH/GSSG as total antioxidant capacity in patients with head and neck SCC (HNSCC) and to subsequently compare them with healthy controls...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29497306/new-developments-in-the-management-of-head-and-neck-cancer-impact-of-pembrolizumab
#12
REVIEW
Khalil Saleh, Roland Eid, Fady Gh Haddad, Nadine Khalife-Saleh, Hampig Raphaël Kourie
Head and neck squamous cell carcinoma (HNSCC), a heterogeneous group of upper aerodigestive tract malignancies, is the seventh most common cancer worldwide. Tobacco use and alcohol consumption were the most identified risk factors of HNSCC. However, human papilloma virus, a sexually transmitted infection, has been determined as another primary cause of HNSCC. Early-stage disease is treated with surgery or radiotherapy. Recurrent or metastatic HNSCC is associated with poor prognosis with a median overall survival of 10 months...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29490660/identification-and-validation-a-tgf-%C3%AE-associated-long-non-coding-rna-of-head-and-neck-squamous-cell-carcinoma-by-bioinformatics-method
#13
Teng Huang, Wei Huang, Hong Lu, Bi-Yun Zhang, Jun Ma, Di Zhao, Yi-Jun Wang, Da-Hai Yu, Xia He
BACKGROUND: The role of transforming growth factorβ (TGF-β)-induced tumor progression in advanced malignancy is well established, but the involvement of long non-coding RNAs (lncRNAs) in TGF-β signaling remains unclear. This study aimed to identify TGF-β-associated lncRNAs in head and neck squamous cell carcinoma (HNSCC). METHODS: Expression profiling of lncRNAs was obtained using Gene Expression Omnibus and The Cancer Genome Atlas. Real-time quantitative PCR was used to analyze the expression of EPB41L4A-AS2 in HNSCC cell line...
February 28, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29464975/pembrolizumab-and-its-use-in-the-treatment-of-recurrent-or-metastatic-head-and-neck-cancer
#14
Siddharth Sheth, Jared Weiss
Until recently, palliative options for the treatment of platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) have been cytotoxic chemotherapy and EGFR inhibitors. These agents offer limited efficacy with substantial toxicity. The development of novel immune checkpoint inhibitors has challenged the standard treatment. Pembrolizumab is a potent and highly selective humanized monoclonal antibody that blocks the interaction between PD-1, an immune checkpoint receptor and its ligands PD-L1 and -2...
February 21, 2018: Future Oncology
https://www.readbyqxmd.com/read/29464035/upregulation-of-cell-cycle-genes-in-head-and-neck-cancer-patients-may-be-antagonized-by-erufosine-s-down-regulation-of-cell-cycle-processes-in-oscc-cells
#15
Shariq S Ansari, Ashwini K Sharma, Michael Zepp, Elizabet Ivanova, Frank Bergmann, Rainer König, Martin R Berger
The TCGA database was analyzed to identify deregulation of cell cycle genes across 24 cancer types and ensuing effects on patient survival. Pan-cancer analysis showed that head and neck squamous cell carcinoma (HNSCC) ranks amongst the top four cancers showing deregulated cell cycle genes. Also, the median gene expression of all CDKs and cyclins in HNSCC patient samples was higher than that of the global gene expression. This was verified by IHC staining of CCND1 from HNSCC patients. When evaluating the quartiles with highest and lowest expression, increased CCND1/CDK6 levels had negative implication on patient survival...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29461598/association-on-polymorphisms-in-lncrna-hotair-and-susceptibility-to-hnscc-in-chinese-population
#16
B Wu, J Liu, B Wang, X Liao, Z Cui, N Ding
OBJECTIVE: More and more evidence has shown that the critical functions of long non-coding RNA (lncRNA) polymorphism in the carcinogenicity mechanism of a variety of cancers. The association between lncRNA HOX transcript antisense intergenic RNA (HOTAIR) polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in Chinese population has not been reported. To investigated the effects of HOTAIR polymorphism on cancer susceptibility, the influence of HOTAIR variants on the risk of HNSCC was analyzed in this study...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29431869/separation-of-plasma-derived-exosomes-into-cd3-and-cd3-fractions-allows-for-association-of-immune-cell-and-tumor-cell-markers-with-disease-activity-in-hnscc-patients
#17
Marie-Nicole Theodoraki, Thomas K Hoffmann, Theresa L Whiteside
Head and neck squamous cell carcinoma (HNSCC) is a highly immunosuppressive malignancy. Exosomes in HNSCC patients' plasma are enriched in inhibitory cargo and mediate immunosuppression. As these exosomes are products of various cells, the cellular origin of immunoregulatory proteins they carry is unknown. To test whether tumor- or T cell-derived exosomes in patient's plasma are immunosuppressive and impact on disease activity, we separated CD3(-) from CD3(+) exosomes by immunocapture using anti-CD3 Abs. The exosome protein cargo was evaluated for immunoregulatory proteins using on-bead flow cytometry...
February 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29428866/prognostic-value-of-circulating-biomarker-score-in-advanced-stage-head-and-neck-squamous-cell-carcinoma
#18
Marn Joon Park, Jong-Lyel Roh, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Circulating biomarker (CB) is a convenient, emerging predictive tool for treatment response and outcomes in human cancers. Therefore, we examined the prognostic value of pre-treatment and early post-treatment CBs and their summated scores in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This study prospectively included 310 consecutive patients who underwent definitive treatment for previously untreated advanced-stage HNSCC between 2010 and 2015...
February 8, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29425237/intragenic-dna-methylation-of-pitx1-and-the-adjacent-long-non-coding-rna-c5orf66-as1-are-prognostic-biomarkers-in-patients-with-head-and-neck-squamous-cell-carcinomas
#19
Verena Sailer, Arthur Charpentier, Joern Dietrich, Timo J Vogt, Alina Franzen, Friedrich Bootz, Dimo Dietrich, Andreas Schroeck
BACKGROUND: Patients with squamous cell cancer of the head and neck region (HNSCC) are at risk for disease recurrence and metastases, even after initial successful therapy. A tissue-based biomarker could be beneficial to guide treatment as well as post-treatment surveillance. Gene methylation status has been recently identified as powerful prognostic biomarker in HNSCC. We therefore evaluated the methylation status of the homeobox gene PITX1 and the adjacent long intergenic non-coding RNA (lincRNA) C5orf66-AS1 in publicly available datasets...
2018: PloS One
https://www.readbyqxmd.com/read/29423108/cancer-immunogenomic-approach-to-neoantigen-discovery-in-a-checkpoint-blockade-responsive-murine-model-of-oral-cavity-squamous-cell-carcinoma
#20
Paul Zolkind, Dariusz Przybylski, Nemanja Marjanovic, Lan Nguyen, Tianxiang Lin, Tanner Johanns, Anton Alexandrov, Liye Zhou, Clint T Allen, Alexander P Miceli, Robert D Schreiber, Maxim Artyomov, Gavin P Dunn, Ravindra Uppaluri
Head and neck squamous cell carcinomas (HNSCC) are an ideal immunotherapy target due to their high mutation burden and frequent infiltration with lymphocytes. Preclinical models to investigate targeted and combination therapies as well as defining biomarkers to guide treatment represent an important need in the field. Immunogenomics approaches have illuminated the role of mutation-derived tumor neoantigens as potential biomarkers of response to checkpoint blockade as well as representing therapeutic vaccines...
January 9, 2018: Oncotarget
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