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https://www.readbyqxmd.com/read/29893275/evaluation-of-xrcc1-gene-polymorphism-as-a-biomarker-in-head-and-neck-cancer-patients-undergoing-chemoradiation-therapy
#1
Sambit Swarup Nanda, Ajeet Kumar Gandhi, Madhup Rastogi, Rohini Khurana, Rahat Hadi, Kamal Sahni, Surendra Prasad Mishra, Anoop K Srivastava, Madan Lal Brahma Bhatt, Devendra Parmar
PURPOSE: We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT). METHODS AND MATERIALS: In this prospective cohort study, we included 101 patients with HNSCC (oral cavity, pharynx, and larynx) who were aged ≥ 18 years, had stage III to IVB disease, had a Karnofsky Performance Status ≥ 80, and were deemed fit for CCRT...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29872508/prognostic-value-of-midkine-expression-in-patients-with-solid-tumors-a-systematic-review-and-meta-analysis
#2
Luo Zhang, Xing Song, Yingjie Shao, Changping Wu, Jingting Jiang
Background: Accumulated studies have shown the important role of Midkine (MDK) protein in various solid tumors and indicated its correlation with patients' survival. This meta-analysis was performed to further explore the prognostic value of MDK expression in solid tumors. Materials and Methods: We collected the literatures through searching PubMed, Embase and the Cochrane Library (last up to April 10, 2017) to assess the effect of MDK on survival in solid tumor patients...
May 15, 2018: Oncotarget
https://www.readbyqxmd.com/read/29846905/ezrin-radixin-moesin-binding-phosphoprotein-50-a-potential-novel-biomarker-in-human-papilloma-virus-associated-head-and-neck-squamous-cell-carcinomas
#3
Athiva Shankar, Dorothy H Crouch, Michaelina Macluskey
High-risk human papilloma virus (HR-HPV) has increasingly been associated with head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal cancers. Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50), a putative tumour suppressor, localises to the plasma membrane in suprabasal epithelium and to the cytoplasm in proliferative basal layers, and is a target for degradation by the HR-HPV E6 oncoprotein. The aim of this study was to investigate EBP50 protein expression patterns in HNSCC in a large Scottish cohort to determine if there was a correlation with HPV status and clinical outcomes...
May 30, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29808687/-micrornas-in-prediction-of-response-to-radiotherapy-in-head-and-neck-cancer-patients-pilot-study
#4
P Ahmad, M Slavík, J Šána, M Hermanová, P Šlampa, P Smilek, T Kazda, O Slabý
BACKGROUND: Radiotherapy plays a key role in the treatment of squamous cell head and neck cancers (HNSCC). The effectivity of radiation therapy is often limited by radioresistance of these tumours. microRNAs (miRNAs) are endogenous, evolutionary conserved, small non-coding RNAs involved in regulation of cellular processes associated with radioresistance. The objective of this study was to identify miRNA profile enabling to predict the radiation treatment outcomes in HNSCC patients. MATERIAL AND METHODS: The retrospective study included HNSCC patients who underwent a definitive radiotherapy...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29807113/comprehensive-pharmacogenomic-profiling-of-human-papillomavirus-positive-and-negative-squamous-cell-carcinoma-identifies-sensitivity-to-aurora-kinase-inhibition-in-kmt2d-mutants
#5
Nene N Kalu, Tuhina Mazumdar, Shaohua Peng, Pan Tong, Li Shen, Jing Wang, Upasana Banerjee, Jeffrey N Myers, Curtis R Pickering, David Brunell, Clifford C Stephan, Faye M Johnson
To address the unmet need for effective biomarker-driven targeted therapy for human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) and cervical cancer, we conducted a high-throughput drug screen using 1122 compounds in 13 HPV-positive and 11 matched HPV-negative cell lines. The most effective drug classes were inhibitors of polo-like kinase, proteasomes, histone deacetylase, and Aurora kinases. Treatment with a pan-Aurora inhibitor, danusertib, led to G2M arrest and apoptosis in vitro...
May 25, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#6
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29743718/expressional-analysis-of-disease-relevant-signalling-pathways-in-primary-tumours-and-metastasis-of-head-and-neck-cancers
#7
Dorothee Goesswein, Negusse Habtemichael, Aslihan Gerhold-Ay, Johanna Mazur, Désirée Wünsch, Shirley K Knauer, Julian Künzel, Christoph Matthias, Sebastian Strieth, Roland H Stauber
Head and neck squamous cell carcinoma (HNSCC) often metastasize to lymph nodes resulting in poor prognosis for patients. Unfortunately, the underlying molecular mechanisms contributing to tumour aggressiveness, recurrences, and metastasis are still not fully understood. However, such knowledge is key to identify biomarkers and drug targets to improve prognosis and treatments. Consequently, we performed genome-wide expression profiling of 15 primary HNSSCs compared to corresponding lymph node metastases and non-malignant tissue of the same patient...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741610/aff4-promotes-tumorigenesis-and-tumor-initiation-capacity-of-head-and-neck-squamous-cell-carcinoma-cells-by-regulating-sox2
#8
Peng Deng, Jiongke Wang, Xuefeng Zhang, Xingyu Wu, Ning Ji, Jing Li, Min Zhou, Lu Jiang, Xin Zeng, Qianming Chen
Super elongation complex (SEC) controls gene transcription by releasing Pol II from pausing. Previous studies have shown that dysfunction of SEC was associated with multiple human cancers, such as leukemia and breast cancer. However, the role of SEC in head and neck squamous cell carcinoma (HNSCC) development remains largely unknown. In this study, we found expression of AF4/FMR2 family member 4 (AFF4), the core component of SEC, was upregulated dramatically in HNSCC cell lines and tumor tissues. By using siRNA-mediated depletion and overexpression of AFF4, we demonstrated AFF4 promoted proliferation, migration and invasion of HNSCC cells...
May 8, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29721063/photoacoustic-imaging-as-an-early-biomarker-of-radio-therapeutic-efficacy-in-head-and-neck-cancer
#9
Laurie J Rich, Austin Miller, Anurag K Singh, Mukund Seshadri
The negative impact of tumor hypoxia on radiotherapeutic efficacy is well recognized. However, an easy to use, reliable imaging method for assessment of tumor oxygenation in routine clinical practice remains elusive. Photoacoustic imaging (PAI) is a relatively new imaging technique that utilizes a combination of light and ultrasound (US) to enable functional imaging of tumor hemodynamic characteristics in vivo . Several clinical trials are currently evaluating the utility of PAI in cancer detection for breast, thyroid, and prostate cancer...
2018: Theranostics
https://www.readbyqxmd.com/read/29719599/fanconi-anemia-and-homologous-recombination-gene-variants-are-associated-with-functional-dna-repair-defects-in-vitro-and-poor-outcome-in-patients-with-advanced-head-and-neck-squamous-cell-carcinoma
#10
Caroline V M Verhagen, David M Vossen, Kerstin Borgmann, Floor Hageman, Reidar Grénman, Manon Verwijs-Janssen, Lisanne Mout, Roel J C Kluin, Marja Nieuwland, Tesa M Severson, Arno Velds, Ron Kerkhoven, Mark J O'Connor, Martijn van der Heijden, Marie-Louise van Velthuysen, Marcel Verheij, Volkert B Wreesmann, Lodewyk F A Wessels, Michiel W M van den Brekel, Conchita Vens
Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their functional impact and clinical relevance in head and neck squamous cell carcinoma (HNSCC) is unknown. We therefore questioned whether functional FA/HR defects occurred in HNSCC and whether they are associated with FA/HR variants. We assayed a panel of 29 patient-derived HNSCC cell lines and found that a considerable fraction is hypersensitive to the crosslinker Mitomycin C and PARP inhibitors, a functional measure of FA/HR defects...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719593/whole-exome-sequencing-identifies-mtor-and-keap1-as-potential-targets-for-radiosensitization-of-hnscc-cells-refractory-to-egfr-and-%C3%AE-1-integrin-inhibition
#11
Erik Klapproth, Ellen Dickreuter, Falk Zakrzewski, Michael Seifert, Andreas Petzold, Andreas Dahl, Evelin Schröck, Barbara Klink, Nils Cordes
Intrinsic and acquired resistances are major obstacles in cancer therapy. Genetic characterization is commonly used to identify predictive or prognostic biomarker signatures and potential cancer targets in samples from therapy-naïve patients. By far less common are such investigations to identify specific, predictive and/or prognostic gene signatures in patients or cancer cells refractory to a specific molecular-targeted intervention. This, however, might have a great value to foster the development of tailored, personalized cancer therapy...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29682090/the-neuropeptide-genes-sst-tac1-hcrt-npy-and-gal-are-powerful-epigenetic-biomarkers-in-head-and-neck-cancer-a-site-specific-analysis
#12
Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Ryuji Ishikawa, Takeharu Kanazawa, Hiroyuki Mineta
Background: Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause death is a critical research area, particularly if the biomarker can be linked to selection of patients. Therefore, to identify potential alternative prognostic markers, we investigated the methylation status of five neuropeptide gene promoters. The promoter methylation status was determined by quantitative methylation-specific PCR in 230 cases of HNSCC; 58 hypopharynx, 45 larynx, 56 oropharynx, and 71 oral cavity tumor samples were studied...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29667751/suz12-is-a-novel-putative-oncogene-promoting-tumorigenesis-in-head-and-neck-squamous-cell-carcinoma
#13
Yaping Wu, Huijun Hu, Wei Zhang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Yanling Wang, Jianrong Yang, Jie Cheng
The suppressor of zest 12 (SUZ12), one of the core polycomb repressive complex 2 (PRC2) components, has increasingly appreciated as a key mediator during human tumorigenesis. However, its expression pattern and oncogenic roles in head and neck squamous cell carcinoma (HNSCC) remain largely unexplored yet. Here, we sought to determine its expression pattern, clinicopathological significance and biological roles in HNSCC. Through data mining and interrogation from multiple publicly available databases, our bioinformatics analyses revealed that SUZ12 mRNA was significantly overexpressed in multiple HNSCC patient cohorts...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29626364/elevated-expression-of-keratin-17-in-oropharyngeal-squamous-cell-carcinoma-is-associated-with-decreased-survival
#14
Elliot Regenbogen, Michelle Mo, Jamie Romeiser, A Laurie W Shroyer, Luisa F Escobar-Hoyos, Stephanie Burke, Kenneth R Shroyer
BACKGROUND: Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. METHODS: Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa...
April 6, 2018: Head & Neck
https://www.readbyqxmd.com/read/29599009/incremental-prognostic-value-of-apparent-diffusion-coefficient-histogram-analysis-in-head-and-neck-squamous-cell-carcinoma
#15
Xiaoxia Li, Ying Yuan, Jiliang Ren, Yiqian Shi, Xiaofeng Tao
RATIONALE AND OBJECTIVES: We aimed to investigate the incremental prognostic value of apparent diffusion coefficient (ADC) histogram analysis in patients with head and neck squamous cell carcinoma (HNSCC) and integrate it into a multivariate prognostic model. MATERIALS AND METHODS: A retrospective review of magnetic resonance imaging findings was conducted in patients with pathologically confirmed HNSCC between June 2012 and December 2015. For each tumor, six histogram parameters were derived: the 10th, 50th, and 90th percentiles of ADC (ADC10 , ADC50 , and ADC90 ); mean ADC values (ADCmean ); kurtosis; and skewness...
March 26, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29594214/sdf-1-cxcr4-expression-in-head-and-neck-cancer-and-outcome-after-postoperative-radiochemotherapy
#16
Chiara De-Colle, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Christine Bayer, Claus Belka, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips, Apostolos Menegakis
Introduction: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches. Preclinical and first clinical observations showed that the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12) play an important role in tumour cell proliferation, survival, cancer progression, metastasis and treatment resistance...
August 2017: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29581773/epigenetic-modification-of-sall1-as-a-novel-biomarker-for-the-prognosis-of-early-stage-head-and-neck-cancer
#17
Kiyoshi Misawa, Yuki Misawa, Atsushi Imai, Daiki Mochizuki, Shiori Endo, Masato Mima, Ryuji Ishikawa, Hideya Kawasaki, Takashi Yamatodani, Takeharu Kanazawa
This study examined Sal-like protein ( SALL)1 methylation profiles in head and neck squamous-cell carcinoma (HNSCC) patients at diagnosis and follow-up, and evaluated their prognostic significance and value as a biomarker. SALL1 expression was examined in a panel of cell lines by quantitative reverse transcription PCR (qRT-PCR). Promoter methylation was determined by quantitative methylation-specific polymerase chain reaction (qMSP) and was compared to the clinical characteristics of 205 samples. SALL1 promoter methylation was associated with transcriptional inhibition and was correlated with disease recurrence in 31...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29578359/approach-to-oligometastatic-disease-in-head-and-neck-cancer-on-behalf-of-the-gortec
#18
Xu Shan Sun, Cécile Michel, Emmanuel Babin, Dominique De Raucourt, Adeline Péchery, Elisabeta Gherga, Bernard Géry, Carmen Florescu, Jean Bourhis, Juliette Thariat
Median survival for recurrent/metastatic head and neck squamous cell cancer (HNSCC) patients is about 10 months after first-line best systemic treatment. We aimed to assess current approaches of oligometastatic HNSCC patients by the analysis of current concept and published data (1995-2017) in this population. Five-year survival rates are over 20% in selected patients who undergo metastasis-directed therapy by either surgery or stereotactic irradiation. Human papillomavirus(+) HNSCC patients have more disseminated metastases but respond more favorably and also benefit from ablative treatments...
April 2018: Future Oncology
https://www.readbyqxmd.com/read/29569374/overexpression-of-wd-repeat-domain-5-associates-with-aggressive-clinicopathological-features-and-unfavorable-prognosis-in-head-neck-squamous-cell-carcinoma
#19
Yaping Wu, Pengfei Diao, Zhongwu Li, Wei Zhang, Dongmiao Wang, Yanling Wang, Jie Cheng
BACKGROUND: WD repeat domain 5 (WDR5), a core member of Mixed lineage leukemia (MLL) and SET1 histone H3 lysine 4 (H3K4) methyltransferase complexes, is involved in multiple biological and pathological processes. Its deregulation in cancer and pro-tumorigenic roles has been increasingly appreciated. However, the expression pattern of WDR5 and its biological functions in head neck squamous cell carcinoma (HNSCC) have not been well established. METHODS: The expression of WDR5 mRNA in HNSCC was determined by data mining and interrogation using publicly available databases...
May 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29560108/the-aurora-kinase-a-phe31-ile-polymorphism-as-possible-predictor-of-response-to-treatment-in-head-and-neck-squamous-cell-carcinoma
#20
Alexander Baumann, Anna Maria S Buchberger, Guido Piontek, Dominik Schüttler, Martina Rudelius, Rudolf Reiter, Lena Gebel, Gerhard Piendl, Gero Brockhoff, Anja Pickhard
Recently the Aurora-Kinases (Aurk) moved into the focus as novel disease related biomarkers and therapeutic targets. Elevated Aurora-Kinase expression has been found in a number of malignancies, amongst them HNSCC. For esophageal cancer, the AurkA Phe31-Ile polymorphism has previously been associated with tumor progression. Here we evaluated the treatment efficiency of HNSCC cell radiation as a function of Aurora-Kinases in HNSCC cell lines. Moreover, we investigated a potential sensitization to radiation by a cell treatment with the inhibitors Alisertib, Barasertib, Docetaxel and VX-680...
February 27, 2018: Oncotarget
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