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biomarkers in Head and neck cancers

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https://www.readbyqxmd.com/read/28325958/micrornas-involvement-in-radioresistance-of-head-and-neck-cancer
#1
REVIEW
Parwez Ahmad, Jiri Sana, Marek Slavik, Pavel Slampa, Pavel Smilek, Ondrej Slaby
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs...
2017: Disease Markers
https://www.readbyqxmd.com/read/28316053/the-use-of-rapid-and-cost-effective-blood-based-biomarkers-in-combination-with-tumour-tnm-stage-for-individual-head-and-neck-cancer-patient-treatment-selection
#2
REVIEW
Nongnit Laytragoon Lewin, Freddi Lewin, Bengt-Åke Andersson, Sture Löfgren, Lars Erik Rutqvist
Head and neck (H&N) cancer is an aggressive disease and the incidence has increased in younger population worldwide. Tumour TNM staging is the main basis for treatment decision despite significant variation in clinical outcome. Survival time of these patients has marginally improved during the last 30 years. Various biomarkers with cumbersome analysis, high cost, time consumption and requirement of special laboratory facilities have been investigated. However, none of these biomarkers have been shown to be suitable to use for individual H&N cancer patient treatment selection in the clinic...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28276321/downregulation-of-calcium-binding-protein-s100a9-inhibits-hypopharyngeal-cancer-cell-proliferation-and-invasion-ability-through-inactivation-of-nf%C3%AE%C2%BAb-signaling
#3
Ping Wu, Huatao Quan, Jing Kang, Jian He, Shi Luo, Chubo Xie, Jing Xu, Yaoyun Tang, Suping Zhao
Hypopharyngeal cancer (HPC) frequently present at an advanced stage, and display early submucosal spread, resulting inpoor prognosis, among the worst of all head and neck subsites. Detection of HPC at an earlier stage would be beneficial to patients. In this study, we used Differential in-gel electrophoresis (DIGE) and two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics analysis to indentify the potential biomarkers for HPC. Among the differential proteins identified, calcium binding protein S100A9 was overexpressed in HPC tissues compared with normal adjacent tissues, and S100A9 expression in metastatic tissues and advanced tumor tissues was higher than in non-metastatic tissues and early tumor tissues, respectively...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28261818/on-the-impact-of-smoothing-and-noise-on-robustness-of-ct-and-cbct-radiomics-features-for-patients-with-head-and-neck-cancers
#4
Hassan Bagher-Ebadian, Farzan Siddiqui, Liu Chang, Benjamin Movsas, Indrin J Chetty
PURPOSE: We investigated the characteristics of radiomics features extracted from planning CT (pCT) and cone beam CT (CBCT) image datasets acquired for 18 oropharyngeal cancer patients treated with fractionated radiation therapy. Images were subjected to smoothing, sharpening, and noise to evaluate changes in features relative to baseline datasets. METHODS: Textural features were extracted from tumor volumes, contoured on pCT and CBCT images, according to the following 8 different classes: Intensity Based Histogram Features (IBHF), Gray Level Run Length (GLRL), Law's Textural information (LAWS), Discrete Orthonormal Stockwell Transform (DOST), Local Binary Pattern (LBP), Two-Dimensional Wavelet Transform (2DWT), Two Dimensional Gabor Filter (2DGF), and Gray Level Co-Occurrence Matrix (GLCM)...
March 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28261333/surveilling-the-potential-for-precision-medicine-driven-pd-1-pd-l1-targeted-therapy-in-hnscc
#5
REVIEW
J E Mann, R Hoesli, N L Michmerhuizen, S N Devenport, M L Ludwig, T R Vandenberg, C Matovina, N Jawad, M Mierzwa, A G Shuman, M E Spector, J C Brenner
Immunotherapy is becoming an accepted treatment modality for many patients with cancer and is now approved for use in platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Despite these successes, a minority of patients with HNSCC receiving immunotherapy respond to treatment, and few undergo a complete response. Thus, there is a critical need to identify mechanisms regulating immune checkpoints in HNSCC such that one can predict who will benefit, and so novel combination strategies can be developed for non-responders...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28245169/long-non-coding-rna-linc0086-functions-as-a-tumor-suppressor-in-nasopharyngeal-carcinoma-by-targeting-mir-214
#6
Jie Guo, Jinqi Ma, Guosheng Zhao, Guocai Li, Yunfeng Fu, Yanwei Luo
Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, occurring at high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including NPC. Here, we established a comprehensive lncRNA profiles in NPC and found that 35 lncRNAs were differentially expressed in NPC. We found that LINC0086 decreased in NPC patient serum samples and tissues. The Kaplan-Meier survival cure showed that the patients with high LINC0086 expression had higher survival rate than those with low LINC0086 expression...
February 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28231582/radiomics-in-head-and-neck-cancer-extracting-valuable-information-from-data-beyond-recognition
#7
Kathrin Scheckenbach, Lena Colter, Martin Wagenmann
In oncology, biomarkers that describe the characteristics of a malignancy on different levels (clinical, histological, molecular) and the patient's outcome and treatment response are increasingly integrated into the clinical routine. Extensive screening tools, "omics," offer incredible opportunities and vast amounts of data. During the last years, the field of "omics" gained a new promising partner, the "radiomics." Based on radiological imaging, multiple features can be extracted and linked to clinical, genomic, and histopathological data from other sources...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28195818/notch1-overexpression-correlates-to-improved-survival-in-cancer-of-the-oropharynx
#8
Azeem S Kaka, Nicholas B Nowacki, Bhavna Kumar, Songzhu Zhao, Matthew O Old, Amit Agrawal, Enver Ozer, Ricardo L Carrau, David E Schuller, Pawan Kumar, Theodoros N Teknos
Objectives The Notch1 signaling pathway has recently been shown to be highly dysregulated in head and neck squamous cell carcinoma, but the value of Notch1 as a predictive biomarker is yet to be elucidated in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study is to evaluate Notch1 expression in surgical OPSCC specimens and determine clinicopathologic correlates. Study Design Case series with planned data collection. Setting Tertiary academic medical center. Subjects and Methods Surgical specimens from 181 patients with OPSCC were collected to create a tissue microarray (TMA)...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28192747/biology-and-patterns-of-response-to-egfr-inhibition-in-squamous-cell-cancers-of-the-lung-and-head-neck
#9
REVIEW
Rosalyn A Juergens, Scott V Bratman, Ming-Sound Tsao, Scott A Laurie, M Sara Kuruvilla, Albiruni R A Razak, Aaron R Hansen
The identification of common molecular aberrations that drive cancer progression has led to targeted therapies that improve treatment efficacy in many tumor types. Epidermal growth factor receptor (EGFR) inhibitors have been used to treat both lung and head and neck cancers with squamous cell histology. These tumors often show high EGFR expression and/or increased gene copy number, but low incidence of the activating kinase domain mutations common to adenocarcinomas of the lung. In this manuscript, we review clinical trial data on EGFR-inhibitors in the treatment of squamous cell carcinoma (SqCC) of the lung and head and neck (SCCHN), including both efficacy and biomarker analyses...
March 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28184180/serum-proteomic-based-analysis-identifying-autoantibodies-against-prdx2-and-prdx3-as-potential-diagnostic-biomarkers-in-nasopharyngeal-carcinoma
#10
Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li, Yu-Hui Peng
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC. METHODS: We used serological proteome analysis to identify candidate autoantibodies against tumor-associated antigens. Levels of autoantibodies and Epstein-Barr virus capsid antigen-IgA (VCA-IgA) were measured by ELISA in 129 patients with NPC and 100 normal controls...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28184025/metabolic-interrogation-as-a-tool-to-optimize-chemotherapeutic-regimens
#11
Vlad C Sandulache, Yunyun Chen, Lei Feng, William N William, Heath D Skinner, Jeffrey N Myers, Raymond E Meyn, Jinzhong Li, Ainiwaer Mijiti, James A Bankson, Clifton D Fuller, Marina Y Konopleva, Stephen Y Lai
Platinum-based (Pt) chemotherapy is broadly utilized in the treatment of cancer. Development of more effective, personalized treatment strategies require identification of novel biomarkers of treatment response. Since Pt compounds are inactivated through cellular metabolic activity, we hypothesized that metabolic interrogation can predict the effectiveness of Pt chemotherapy in a pre-clinical model of head and neck squamous cell carcinoma (HNSCC).We tested the effects of cisplatin (CDDP) and carboplatin (CBP) on DNA damage, activation of cellular death cascades and tumor cell metabolism, specifically lactate production...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28183993/multiparametric-imaging-of-tumor-hypoxia-and-perfusion-with-18-f-fmiso-dynamic-pet-in-head-and-neck-cancer
#12
Milan Grkovski, Heiko Schöder, Nancy Lee, Sean D Carlin, Bradley Jay Beattie, Nadeem Riaz, Jonathan E Leeman, Joseph A O'Donoghue, John Laurence Humm
Tumor hypoxia and perfusion are independent prognostic indicators of patient outcome. We developed the methodology for, and investigated the utility of multiparametric imaging of tumor hypoxia and perfusion with (18)F-fluoromisonidazole (FMISO) dynamic positron emission tomography (dPET) in head and neck cancer (HNC). Methods: 120 HNC patients underwent 0-30 min FMISO dPET in a customized immobilization mask, followed by 10 min static acquisitions starting at 93±6 and 160±13 min post-injection. A total of 248 lesions (≥2 cm(3)) were analyzed...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28179315/validation-of-human-papillomavirus-as-a-favourable-prognostic-marker-and-analysis-of-cd8-tumour-infiltrating-lymphocytes-and-other-biomarkers-in-cancer-of-unknown-primary-in-the-head-and-neck-region
#13
Lars Sivars, David Landin, Nathalie Grün, Andrea Vlastos, Linda Marklund, Sushma Nordemar, Torbjörn Ramqvist, Eva Munck-Wikland, Anders Näsman, Tina Dalianis
BACKGROUND: Human papillomavirus (HPV) is a favourable prognostic factor in oropharyngeal cancer. Moreover, we and others reported that HPV-positive cancer of unknown primary in the head and neck region (HNCUP) has better outcome than HPV-negative HNCUP. However, not all studies concord. Here, our previous finding was investigated in a new cohort and additional biomarkers were analyzed. MATERIALS AND METHODS: A total of 19 HNCUPs diagnosed 2008-2013 were analyzed for HPV DNA by polymerase chain reaction assay (PCR) and p16 by immunohistochemistry (IHC)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28174607/pitx3-dna-methylation-is-an-independent-predictor-of-overall-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#14
Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck, Dimo Dietrich
BACKGROUND: Molecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation is a frequent event in cancer and, therefore, a promising source for potential biomarkers. Here, the methylation status of the paired-like homeodomain transcription factor 3 (PITX3) was evaluated in HNSCC. METHODS: Using a quantitative real-time PCR, PITX3 methylation was assessed in a cohort of 326 HNSCC patients treated for localized or locally advanced disease (training cohort)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28168879/head-and-neck-squamous-cell-carcinoma-metabolism-draws-on-glutaminolysis-and-stemness-is-specifically-regulated-by-glutaminolysis-via-aldehyde-dehydrogenase
#15
Pachiyappan Kamarajan, Thekkelnaycke M Rajendiran, Jason Kinchen, Mercedes Bermúdez, Theodora Danciu, Yvonne L Kapila
Cancer cells use alternate energetic pathways; however, cancer stem cell (CSC) metabolic energetic pathways are unknown. The purpose of this study was to define the metabolic characteristics of head and neck cancer at different points of its pathogenesis with a focus on its CSC compartment. UPLC-MS/MS-profiling and GC-MS-validation studies of human head and neck cancer tissue, saliva, and plasma were used in conjunction with in vitro and in vivo models to carry out this investigation. We identified metabolite biomarker panels that distinguish head and neck cancer from healthy controls, and confirmed involvement of glutamate and glutaminolysis...
March 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28160562/the-tumor-suppressor-capability-of-p53-is-dependent-on-non-muscle-myosin-iia-function-in-head-and-neck-cancer
#16
Sonya D Coaxum, Jessica Tiedeken, Elizabeth Garrett-Mayer, Jeffrey Myers, Steven A Rosenzweig, David M Neskey
Over 300,000 patients develop squamous cell carcinoma of the head and neck (HNSCC) worldwide with 25-30% of patients ultimately dying from their disease. Currently, molecular biomarkers are not used in HNSCC but several genes have been identified including mutant TP53 (mutp53). Our recent work has identified an approach to stratify patients with tumors harboring high or low risk TP53 mutations. Non-muscle Myosin IIA (NMIIA) was recently identified as a tumor suppressor in HNSCC. We now demonstrate that low MYH9 expression is associated with decreased survival in patients with head and neck cancer harboring low-risk mutp53 but not high-risk mutp53...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28149885/potential-biomarkers-for-radiosensitivity-in-head-and-neck-cancers
#17
COMMENT
Sherly Pardo-Reoyo, J L Roig-Lopez, Eddy S Yang
Radiotherapy is a mainstay of treatment for head and neck cancer. However, the morbidity of treatment remains a clinical challenge. Molecular profiling has provided further insight into tumor biology and tumor sensitivity to radiation, and this information could be used to personalize treatment. In this review, we discuss published signatures of radiosensitivity and discuss the pathways that may be important in dictating radiation sensitivity. Applications of these signatures could result in less morbidity if dose de-escalation efforts are successful...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28144684/combined-p16-and-p53-expression-in-cervical-cancer-of-unknown-primary-and-other-prognostic-parameters-a-single-center-analysis
#18
Müjdat Yildirim, Jens Müller von der Grün, Ria Winkelmann, Emmanouil Fokas, Franz Rödel, Hanns Ackermann, Claus Rödel, Panagiotis Balermpas
BACKGROUND AND PURPOSE: Cervical cancer of unknown primary (CUP) represents an uncommon and heterogeneous subentity of head and neck cancer. However, both optimal diagnostics and therapy remain unclear. An improved understanding of the underlying pathology is essential to enable future tailored therapies and optimized outcomes. MATERIALS AND METHODS: We retrospectively analyzed 53 patients with head and neck CUP and 48 available cervical lymph node specimens. All patients have received radiotherapy between 2007 and 2015...
April 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28109476/a-three-lncrna-signature-derived-from-the-atlas-of-ncrna-in-cancer-tanric-database-predicts-the-survival-of-patients-with-head-and-neck-squamous-cell-carcinoma
#19
Wei Cao, Jian-Nan Liu, Zeqi Liu, Xu Wang, Ze-Guang Han, Tong Ji, Wan-Tao Chen, Xin Zou
OBJECTIVE: Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). METHOD: We analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial least squares discrimination analysis (OPLS-DA) and 1.5-fold expression change criterion methods. The prognosis prediction model based on the lncRNA signatures and clinical parameters were evaluated using the 5-fold cross validation method...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28104022/-immune-checkpoint-inhibitor-therapy-in-advanced-head-and-neck-cancer
#20
W Hang, Z X Xu, Q Zhang, X Lu, G Liu
Immune checkpoint inhibitor therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, improves the life quality of cancer patients and has joined the ranks of surgery, radiation, and chemotherapy to become a major choice for cancer therapy. Over the past few years, multiple exciting results have been obtained on checkpoint inhibitor therapy in advanced head and neck cancer. However, questions such as patient selection and biomarkers for assessing the therapy are largely unsolved...
January 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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