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Bipolar and Depression

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https://www.readbyqxmd.com/read/29466886/proteomic-approaches-to-identify-blood-based-biomarkers-for-depression-and-bipolar-disorders
#1
Rhian Lauren Preece, Sung Yeon Sarah Han, Sabine Bahn
Major depressive disorder (MDD) and bipolar disorder (BD) are leading causes of disability worldwide, yet many people remain undiagnosed, are misdiagnosed, and/or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms, and there is currently no molecular or brain-imaging diagnostic test available. Identifying and validating protein biomarkers could provide a more accurate and objective means of diagnosis. Areas covered: Proteomics is a powerful tool that enables the identification and quantification of novel candidate biomarkers of disease...
February 22, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29466722/shared-and-distinct-regional-homogeneity-changes-in-bipolar-and-unipolar-depression
#2
Xudong Yao, Zhiyang Yin, Fang Liu, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Yange Wei, Ke Xu, Fei Wang, Yanqing Tang
BACKGROUND: Bipolar depression (BD) is easily misdiagnosed as unipolar depression (UD) or major depressive disorder (MDD) because the depressive symptoms can overlap. Regional homogeneity (ReHo), a measure commonly used for analyzing resting-state fMRI data, has been applied to the study of various neuropsychiatric disorders. However, to date, studies directly comparing BD and UD using ReHo have been relatively scarce. Further investigation is needed to study the latent pathophysiological mechanisms of BD and UD...
February 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29465902/-the-facets-of-creativity-in-the-light-of-bipolar-mood-alterations
#3
Réka Szakács
The link between creativity, as the highest expression form of human achievement, and bipolar disorder came into focus of scientific investigations and research. Accomplished writers, composers and visual artists show a substantially higher rate of affective disorders, prodominantly bipolar mood disorders, comparing to the general population. Then again, patients afflicted with bipolar II subtype (hypomania and depression), as well as persons presenting the mildest form of bipolar mood swings (cyclothymia) possess higher creative skills...
January 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29465478/glutamatergic-modulators-in-depression
#4
Ioline D Henter, Rafael Teixeira de Sousa, Carlos A Zarate
Both preclinical and clinical studies have implicated glutamatergic system dysfunction in the pathophysiology of mood disorders such as bipolar depression and major depressive disorder. In particular, rapid reductions in depressive symptoms have been noted in response to subanesthetic doses of the glutamatergic modulator ketamine in subjects with major depressive disorder or bipolar depression. These results have prompted the repurposing or development of other glutamatergic modulators, both as monotherapy or adjunctive to other therapies...
February 20, 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29465467/outcome-and-predictors-of-remission-in-bipolar-i-patients-experiencing-manic-episode-and-treated-with-oral-antipsychotics-and-or-mood-stabilizers-a-prospective-observational-study-in-italy
#5
Giulio Perugi, Giulia Vannucchi, Margherita Barbuti, Giuseppe Maccariello, Andrea De Bartolomeis, Andrea Fagiolini, Giuseppe Maina
This observational study aimed to identify internal (clinical-demographic, temperamental characteristics) and external (childhood trauma, psychosocial characteristics) factors potentially predicting remission at 12 weeks in bipolar-I patients experiencing manic episode and requiring to start or switch treatment with oral antipsychotics and/or mood stabilizers. The following scales were administered: the Young Mania Rating Scale (YMRS), the Montgomery-Asberg Depression Rating Scale (MADRS), the Functioning Assessment Short Test (FAST), and the Clinical Global Impression for Bipolar Disorders (CGI-BP)...
February 20, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29463705/controlling-of-glutamate-release-by-neuregulin3-via-inhibiting-the-assembly-of-the-snare-complex
#6
Ya-Nan Wang, Dwight Figueiredo, Xiang-Dong Sun, Zhao-Qi Dong, Wen-Bing Chen, Wan-Peng Cui, Fang Liu, Hong-Sheng Wang, Hai-Wen Li, Heath Robinson, Er-Kang Fei, Bing-Xing Pan, Bao-Ming Li, Wen-Cheng Xiong, Lin Mei
Neuregulin3 (NRG3) is a growth factor of the neuregulin (NRG) family and a risk gene of various severe mental illnesses including schizophrenia, bipolar disorders, and major depression. However, the physiological function of NRG3 remains poorly understood. Here we show that loss of Nrg3 in GFAP-Nrg3 f/f mice increased glutamatergic transmission, but had no effect on GABAergic transmission. These phenotypes were observed in Nex-Nrg3 f/f mice, where Nrg3 was specifically knocked out in pyramidal neurons, indicating that Nrg3 regulates glutamatergic transmission by a cell-autonomous mechanism...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29461331/the-effect-of-electroconvulsive-therapy-on-hypoperfusion-in-psychotic-bipolar-depression-a-case-study
#7
Céline Julie De Smet, Bernard Sabbe, J F E Oldenburg
The pharmacological treatment of bipolar depression has low response rates. Twenty percent to 30% of patients have an insufficient response to medication. The guidelines suggest that electroconvulsive therapy (ECT) is the next step. The aim of this case study is to evaluate the effect of ECT on the perfusion of the brain in bipolar depression, while monitoring effects on mood and cognition. We present a case study of 56-year-old female patient who suffered from a psychotic depression and cognitive impairment...
February 14, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29457216/n-acetylcysteine-for-major-mental-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
W Zheng, Q-E Zhang, D-B Cai, X-H Yang, Y Qiu, G S Ungvari, C H Ng, M Berk, Y-P Ning, Y-T Xiang
OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of adjunctive N-acetylcysteine (NAC), an antioxidant drug, in treating major depressive disorder (MDD), bipolar disorder, and schizophrenia. METHODS: The PubMed, Cochrane Library, PsycINFO, CNKI, CBM, and WanFang databases were independently searched and screened by two researchers. Standardized mean differences (SMDs), risk ratios, and their 95% confidence intervals (CIs) were computed...
February 18, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29457195/the-association-between-mood-state-and-chronobiological-characteristics-in-bipolar-i-disorder-a-naturalistic-variable-cluster-analysis-based-study
#9
Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi, Andres Alvarado
BACKGROUND: Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused on examining the individual relationships between affective state and chronobiological characteristics. The aim of this study was to conduct a variable cluster analysis in order to ascertain how mood states are associated with chronobiological traits in bipolar I disorder (BDI)...
February 19, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29454970/increased-cerebrospinal-fluid-complement-c5-levels-in-major-depressive-disorder-and-schizophrenia
#10
Takashi Ishii, Kotaro Hattori, Tomoko Miyakawa, Kentaro Watanabe, Shinsuke Hidese, Daimei Sasayama, Miho Ota, Toshiya Teraishi, Hiroaki Hori, Sumiko Yoshida, Akihiko Nunomura, Kazuyuki Nakagome, Hiroshi Kunugi
Inflammation has been implicated in a variety of psychiatric disorders. We aimed to determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which may reflect activation of the complement system in the brain, are altered in patients with major psychiatric disorders. Additionally, we examined possible associations of CSF C5 levels with clinical variables. Subjects comprised 89 patients with major depressive disorder (MDD), 66 patients with bipolar disorder (BPD), 96 patients with schizophrenia, and 117 healthy controls, matched for age, sex, and ethnicity (Japanese)...
February 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29454221/-13-c-phenylalanine-breath-test-and-serum-biopterin-in-schizophrenia-bipolar-disorder-and-major-depressive-disorder
#11
Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yasuhiro Kajiwara, Yuji Ozeki, Miho Ota, Kotaro Hattori, Teruhiko Higuchi, Hiroshi Kunugi
Phenylalanine is required for the synthesis of the neurotransmitters dopamine, noradrenaline, and adrenaline. The rate-limiting step for phenylalanine metabolism is catalyzed by phenylalanine hydroxylase (PAH) and its cofactor tetrahydrobiopterin. We aimed to detect altered phenylalanine metabolism in major psychiatric disorders using the l-[1-13 C]phenylalanine breath test (13 C-PBT) and serum biopterin levels. We also investigated association of PAH mutations with schizophrenia and phenylalanine metabolism...
February 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29454165/pituitary-gland-shrinkage-in-bipolar-disorder-the-role-of-gender
#12
Giuseppe Delvecchio, Gian Mario Mandolini, Cinzia Perlini, Marco Barillari, Veronica Marinelli, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis (HPAA) has been consistently reported in mood disorders. However, only few studies investigated the Pituitary gland (PG) in Bipolar Disorder (BD) and the results are so far contrasting. Therefore, the aim of this study is to explore the integrity of the PG as well as the role of gender and the impact of clinical measurements on this structure in a sample of BD patients compared to healthy controls (HC). METHODS: 34 BD patients and 41 HC underwent a 1...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454164/self-reported-inhibition-predicts-history-of-suicide-attempts-in-bipolar-disorder-and-major-depression
#13
André Ponsoni, Laura Damiani Branco, Charles Cotrena, Flávio Milman Shansis, Rodrigo Grassi-Oliveira, Rochele Paz Fonseca
BACKGROUND: Studies have reliably identified an association between suicide attempts and executive functions such as decision making (DM) and inhibitory control (IC) in patients with mood disorders. As such, the present study aimed to investigate the association between inhibition, DM, impulsivity and the history of suicide attempts in individuals with bipolar (BD) or major depressive disorder (MDD), identifying which assessment instruments may be most strongly associated with suicide in clinical samples...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454034/add-on-high-frequency-deep-transcranial-magnetic-stimulation-dtms-to-bilateral-prefrontal-cortex-in-depressive-episodes-of-patients-with-major-depressive-disorder-bipolar-disorder-i-and-major-depressive-with-alcohol-use-disorders
#14
Chiara Rapinesi, Georgios D Kotzalidis, Stefano Ferracuti, Nicoletta Girardi, Abraham Zangen, Gabriele Sani, Ruggero N Raccah, Paolo Girardi, Maurizio Pompili, Antonio Del Casale
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is critically involved in mood and alcohol use disorders. OBJECTIVE: We aimed to investigate the safety of intervention with add-on bilateral prefrontal high-frequency deep transcranial magnetic stimulation (dTMS) and between-group differences in treatment response in patients with different types of depressive episodes, including major depressive episodes in the course of major depressive disorder (MDD), bipolar disorder, type I (BD-I), and MDD with alcohol use disorder (MDAUD)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29451588/religiosity-depression-and-quality-of-life-in-bipolar-disorder-a-two-year-prospective-study
#15
André Stroppa, Fernando A Colugnati, Harold G Koenig, Alexander Moreira-Almeida
OBJECTIVE: Few quantitative studies have examined the effect of religious involvement on the course of bipolar disorder (BD). We investigated the effects of religious activity and coping behaviors on the course of depression, mania, and quality of life (QoL) in patients with BD. METHODS: Two-year longitudinal study of 168 outpatients with BD. Linear regression was used to examine associations between religious predictors and outcome variables (manic symptoms, depression, QoL), controlling for sociodemographic variables...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29451300/decreased-anterior-cingulate-activation-in-a-motor-task-in-youths-with-bipolar-disorder
#16
Jace B King, Jeffrey S Anderson, Deborah A Yurgelun-Todd, Punitha Subramaniam, Marie R Ehrler, Melissa P Lopez-Larson
BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29449055/adjunctive-antidepressants-in-bipolar-depression-a-cohort-study-of-six-and-twelve-months-rehospitalization-rates
#17
Yahav Shvartzman, Amir Krivoy, Avi Valevski, Shay Gur, Abraham Weizman, Eldar Hochman
Although antidepressants (ADs) are widely used in bipolar depression, there is weak evidence for their effectiveness and safety in this condition. Furthermore, there is a paucity of studies on the risk-benefit ratio of AD maintenance treatment in bipolar disorder (BD). We compared rehospitalization rates of patients with BD-I depressive episode who were discharged with mood stabilizers (MSs) and/or atypical antipsychotics (AAPs) with or without adjunctive AD. Ninety-eight patients with BD-I who were hospitalized with a depressive episode between 2005 and 2013 were retrospectively followed for 6-months and 1-year rehospitalization rates, as well as time to rehospitalization, according to treatment at discharge: MSs and/or AAPs with or without AD...
February 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29448238/parsing-the-heterogeneity-of-depression-an-exploratory-factor-analysis-across-commonly-used-depression-rating-scales
#18
Elizabeth D Ballard, Julia S Yarrington, Cristan A Farmer, Marc S Lener, Bashkim Kadriu, Níall Lally, Deonte Williams, Rodrigo Machado-Vieira, Mark J Niciu, Lawrence Park, Carlos A Zarate
BACKGROUND: Due to the heterogeneity of depressive symptoms-which can include depressed mood, anhedonia, negative cognitive biases, and altered activity levels-researchers often use a combination of depression rating scales to assess symptoms. This study sought to identify unidimensional constructs measured across rating scales for depression and to evaluate these constructs across clinical trials of a rapid-acting antidepressant (ketamine). METHODS: Exploratory factor analysis (EFA) was conducted on baseline ratings from the Beck Depression Inventory (BDI), the Hamilton Depression Rating Scale (HAM-D), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Snaith-Hamilton Pleasure Rating Scale (SHAPS)...
February 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29446330/effectiveness-in-regular-practice-of-collaborative-care-for-depression-among-adolescents-a-retrospective-cohort-study
#19
Nathan D Shippee, Angela Mattson, RoxAnne Brennan, John Huxsahl, Marcie L Billings, Mark D Williams
OBJECTIVE: Depression is common among adolescents, but many lack ready access to mental health services. Integrated models of care for depression are needed, along with evidence to support their use in regular practice. The authors examined the effectiveness of an ongoing collaborative care program for depressed adolescents embedded in a busy primary care practice. METHODS: This retrospective cohort study assessed EMERALD (Early Management and Evidence-based Recognition of Adolescents Living with Depression), a collaborative care program...
February 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29441710/olfactory-processing-in-bipolar-disorder-major-depression-and-anxiety
#20
Vidyulata Kamath, Diana Paksarian, Lihong Cui, Paul J Moberg, Bruce I Turetsky, Kathleen R Merikangas
OBJECTIVES: Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in individuals with bipolar I disorder (n = 43; n = 13 with psychotic features), bipolar II disorder (n = 48), major depressive disorder (MDD) (n = 134), anxiety (n = 48), and no mental disorder (n = 72) who participated in a community-based family study...
February 13, 2018: Bipolar Disorders
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