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https://www.readbyqxmd.com/read/29757888/ctca-image-quality-improvement-by-using-snapshot-freeze-technique-under-prospective-and-retrospective-electrocardiographic-gating-erratum
#1
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May 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29685695/advanced-analyses-of-computed-tomography-coronary-angiography-can-help-discriminate-ischemic-lesions
#2
Jun-Mei Zhang, Dongsi Shuang, Lohendran Baskaran, Weijun Wu, Soo-Kng Teo, Weimin Huang, Like Gobeawan, John Carson Allen, Ru San Tan, Xi Su, Nasrul Bin Ismail, Min Wan, Boyang Su, Hua Zou, Ris Low, Xiaodan Zhao, Yanling Chi, Jiayin Zhou, Yi Su, Aileen Mae Lomarda, Chee Yang Chin, Jiang Ming Fam, Felix Yung Jih Keng, Aaron Sung Lung Wong, Jack Wei Chieh Tan, Khung Keong Yeo, Philip En Hou Wong, Chee Tang Chin, Kay Woon Ho, Jonathan Yap, Ghassan S Kassab, Terrance Chua, Tian Hai Koh, Swee Yaw Tan, Soo Teik Lim, Liang Zhong
BACKGROUND: Computed tomography coronary angiography (CTCA) image analysis enables plaque characterization and non-invasive fractional flow reserve (FFR) calculation. We analyzed various parameters derived from CTCA images and evaluated their associations with ischemia. METHODS: 49 (61 lesions) patients underwent CTCA and invasive FFR. Lesions with diameter stenosis (DS) ≥ 50% were considered obstructive. CTCA image processing incorporating analytical and numerical methods were used to quantify anatomical parameters of lesion length (LL) and minimum lumen area (MLA); plaque characteristic parameters of plaque volume, low attenuation plaque (LAP) volume, dense calcium volume (DCV), normalized plaque volume (NP Vol), plaque burden, eccentricity index and napkin-ring (NR) sign; and hemodynamic parameters of resistance index, stenosis flow reserve (SFR) and FFRB ...
April 20, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29622992/the-degree-of-hair-graying-as-an-independent-risk-marker-for-coronary-artery-disease-a-ct-coronary-angiography-study
#3
Amr Abdel Aziz ElFaramawy, Irini Samuel Hanna, Reham Mohamed Darweesh, Ahmed Shehata Ismail, Hossam Ibrahim Kandil
Background: Cardiovascular disease is a leading cause of death worldwide. Aging is an unavoidable coronary risk factor and is associated with dermatological signs that could be a marker for increased coronary risk. We tested the hypothesis that hair graying as a visible marker of aging is associated with risk of coronary artery disease (CAD) independent of chronological age. Methods: This cross-sectional study included 545 males who underwent a computed tomography coronary angiography (CTCA) for suspicious of CAD, patients were divided into subgroups according to the percentage of gray/white hairs (Hair Whitening Score, HWS: 1-5) and to the absence or presence of CAD...
March 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29594716/controlled-synthesis-of-polydopamine-a-new-strategy-for-highly-sensitive-fluorescence-turn-on-detection-of-acetylcholinesterase-activity
#4
Meiding Yang, Huipeng Zhou, Yunyi Zhang, Zhenzhen Hu, Niu Niu, Cong Yu
A new water soluble fluorescent coronene probe (CTCA) was synthesized and is shown to display strong fluorescence (with excitation/emission maxima at 313/450 nm) in aqueous solution. Dopamine was oxidized under air to form polydopamine (PDA) which quenches the fluorescence of CTCA. The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Thiocholine inhibits the polymerization of DA, and this leads to recovery in CTCA fluorescence. These findings form the basis for a new method for detection of AChE activity...
January 25, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29576220/fusion-of-three-dimensional-echocardiographic-regional-myocardial-strain-with-cardiac-computed-tomography-for-noninvasive-evaluation-of-the-hemodynamic-impact-of-coronary-stenosis-in-patients-with-chest-pain
#5
Victor Mor-Avi, Mita B Patel, Francesco Maffessanti, Amita Singh, Diego Medvedofsky, S Javed Zaidi, Anuj Mediratta, Akhil Narang, Noreen Nazir, Nadjia Kachenoura, Roberto M Lang, Amit R Patel
BACKGROUND: Combined evaluation of coronary stenosis and the extent of ischemia is essential in patients with chest pain. Intermediate-grade stenosis on computed tomographic coronary angiography (CTCA) frequently triggers downstream nuclear stress testing. Alternative approaches without stress and/or radiation may have important implications. Myocardial strain measured from echocardiographic images can be used to detect subclinical dysfunction. The authors recently tested the feasibility of fusion of three-dimensional (3D) echocardiography-derived regional resting longitudinal strain with coronary arteries from CTCA to determine the hemodynamic significance of stenosis...
March 22, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29564349/computed-tomography-coronary-angiography-is-the-way-forward-for-evaluation-of-children-with-kawasaki-disease
#6
REVIEW
Manphool Singhal, Pankaj Gupta, Surjit Singh, Niranjan Khandelwal
Kawasaki disease (KD) is an acute idiopathic vasculitis affecting infants and children. Coronary artery abnormalities and myocarditis are the major cardiovascular complications of KD. Coronary artery abnormalities develop in 15-25% of untreated KD. Two-dimensional transthoracic echocardiography has hitherto been considered the modality of choice for evaluation of children with KD. There are, however, several limitations inherent to echocardiography - including limited evaluation of distal vessels, left circumflex artery and poor acoustic window in growing children...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29535926/assessment-of-effective-dose-associated-with-coronary-computed-tomography-angiography-in-isfahan-province-iran
#7
Mohammadbagher Tavakoli, Reihane Faraji, Zahra Alirezaei, Zohre Nateghian
Computed tomography coronary angiography (CTCA) has generated a great interest over the past two decades, due to its high diagnostic accuracy and efficacy in the assessment of patients having coronary artery disease. This method is associated with high radiation dose and this has raised serious concerns in the literature. Effective dose (E) is a single parameter meant to reflect the relative risk from exposure to ionizing radiation. Therefore, it is necessary to calculate this parameter to indicate ionizing radiation relative risk...
January 2018: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29513024/radical-changes-to-the-investigation-of-stable-chest-pain-following-the-2016-nice-update
#8
Carl Roobottom
The 2016 National Institute for Health and Care Excellence (NICE) guidelines mark a radical change in the diagnosis of patients with stable chest pain. Quantitative assessments of the disease probability are no longer considered necessary to determine the need and type of diagnostic testing. Instead, the recommendation is for no diagnostic test if the chest pain is judged to be "non-anginal" and CT coronary angiography (CTCA) in patients with "typical" or "atypical" chest pain...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29479383/the-relationship-between-absence-coronary-artery-calcification-and-myocardial-perfusion-single-photon-emission-computed-tomography
#9
Muhannad Alanazi, Alaa AlDuraibi, Mohamamed M Shoukri, Ahmed Fathala
Background: Coronary artery calcification score (CACS) is well validated prognostic tool in coronary artery disease (CAD). The data on the prevalence of myocardial ischemia on myocardial perfusion single photon emission computed tomography (MPS) in symptomatic patients with zero CACS and low to intermediate risk probability is lacking and controversial. The aim of our study was to evaluate the capability of zero CACS to exclude myocardial ischemia on MPS. Methods: A total of 157 patients ((mean age 53 ± 10 years), 88 (56%) female patients, 69 (44%) male patients) who were suspected to have CAD and having low to intermediate pretest likelihood for CAD underwent CACS on dedicated computed tomography (CT) scanners...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29337086/incidental-pulmonary-nodules-are-common-on-ct-coronary-angiogram-and-have-a-significant-cost-impact
#10
James Robertson, Sandra Nicholls, Philip Bardin, Ronnie Ptasznik, Daniel Steinfort, Alistair Miller
BACKGROUND: Computed tomography (CT) coronary angiogram (CTCA) is commonly used for diagnostic evaluation of low-moderate risk patients due to its excellent performance and cost-effectiveness. However, previous cost analyses have not factored in the burden of management of pulmonary nodules, which are a common occurrence. We sought to describe the frequency and characteristics of lung nodules on CTCA in an Australian tertiary hospital, and to assess cost impacts. METHODS: Consecutive CTCAs performed in the calendar year 2012 were retrospectively identified from the imaging department database...
December 5, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29203262/computed-tomography-coronary-angiography-for-evaluation-of-children-with-kawasaki-disease
#11
Manphool Singhal, Surjit Singh, Pankaj Gupta, Avinash Sharma, Niranjan Khandelwal, Jane C Burns
OBJECTIVE: We sought to assess the feasibility of computed tomography coronary angiography (CTCA) on a 128-slice, dual source scanner in children with acute and convalescent phase Kawasaki disease (KD). MATERIALS AND METHODS: A prospective study of 49 children with KD (12 at presentation and 37 in the convalescent phase) was conducted between November 2013 and April 2015. CTCA was performed with either prospective (n = 37) or retrospective (n = 12) electrocardiographic gating...
October 23, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29138258/challenges-in-delivering-computed-tomography-coronary-angiography-as-the-first-line-test-for-stable-chest-pain
#12
John G Dreisbach, Edward D Nicol, Carl A Roobottom, Simon Padley, Giles Roditi
OBJECTIVE: The National Institute for Health and Care Excellence (NICE) clinical guidelines 'chest pain of recent onset: assessment and diagnosis' (update 2016) state CT coronary angiography (CTCA) should be offered as the first-line investigation for patients with stable chest pain. However, the current provision in the UK is unknown. We aimed to evaluate this and estimate the requirements for full implementation of the guidelines including geographical variation. Ancillary aims included surveying the number of CTCA-capable scanners and accredited practitioners in the UK...
November 14, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29080955/fusion-of-ct-coronary-angiography-and-whole-heart-dynamic-3d-cardiac-mr-perfusion-building-a-framework-for-comprehensive-cardiac-imaging
#13
Jochen von Spiczak, Robert Manka, Alexander Gotschy, Sabrina Oebel, Sebastian Kozerke, Sandra Hamada, Hatem Alkadhi
The purpose of this work was to develop a framework for 3D fusion of CT coronary angiography (CTCA) and whole-heart dynamic 3D cardiac magnetic resonance perfusion (3D-CMR-Perf) image data-correlating coronary artery stenoses to stress-induced myocardial perfusion deficits for the assessment of coronary artery disease (CAD). Twenty-three patients who underwent CTCA and 3D-CMR-Perf for various indications were included retrospectively. For CTCA, image quality and coronary diameter stenoses > 50% were documented...
October 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29072898/the-epstein-barr-virus-b-zip-protein-zta-recognizes-specific-dna-sequences-containing-5-methylcytosine-and-5-hydroxymethylcytosine
#14
Desiree Tillo, Sreejana Ray, Khund-Sayeed Syed, Mary Rose Gaylor, Ximiao He, Jun Wang, Nima Assad, Stewart R Durell, Aleksey Porollo, Matthew T Weirauch, Charles Vinson
The Epstein-Barr virus (EBV) B-ZIP transcription factor Zta binds to many DNA sequences containing methylated CG dinucleotides. Using protein binding microarrays (PBMs), we analyzed the sequence specific DNA binding of Zta to four kinds of double-stranded DNA (dsDNA): (1) DNA containing cytosine in both strands, (2) DNA with 5-methylcytosine (5mC) in one strand and cytosine in the second strand, (3) DNA with 5-hydroxymethylcytosine (5hmC) in one strand and cytosine in the second strand, and (4) DNA in which both cytosines in all CG dinucleotides contain 5mC...
November 28, 2017: Biochemistry
https://www.readbyqxmd.com/read/29060821/stenosis-detection-and-quantification-on-cardiac-ctca-using-panoramic-mip-of-coronary-arteries
#15
Y Chi, W Huang, J Zhou, K K Toe, J-M Zhang, P Wong, S T Lim, R S Tan, L Zhong
In this work, we proposed to demonstrate the entire 3D coronary tree using panoramic maximum intensity projection (MIP) of coronary arteries, and to detect and quantify coronary stenosis from computed tomography coronary angiography (CTCA). The performance of the proposed method was assessed in comparison with invasive coronary angiography (ICA) as reference standard. Six anonymized CTCA datasets were tested. MIP method achieved a sensitivity of 82% and a specificity of 95% for the stenosis detection with a good reproducibility (i...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059819/smartool-a-tool-for-clinical-decision-support-for-the-management-of-patients-with-coronary-artery-disease-based-on-modeling-of-atherosclerotic-plaque-process
#16
Antonis I Sakellarios, George Rigas, Vassiliki Kigka, Panagiotis Siogkas, Panagiota Tsompou, Georgia Karanasiou, Themis Exarchos, Ioannis Andrikos, Nikolaos Tachos, Gualtriero Pelosi, Oberdan Parodi, Dimitrios I Fotiaids
SMARTool aims to the development of a clinical decision support system (CDSS) for the management and stratification of patients with coronary artery disease (CAD). This will be achieved by performing computational modeling of the main processes of atherosclerotic plaque growth. More specifically, computed tomography coronary angiography (CTCA) is acquired and 3-dimensional (3D) reconstruction is performed for the arterial trees. Then, blood flow and plaque growth modeling is employed simulating the major processes of atherosclerosis, such as the estimation of endothelial shear stress (ESS), the lipids transportation, low density lipoprotein (LDL) oxidation, macrophages migration and plaque development...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052025/ultra-low-dose-ct-coronary-angiography-using-128-slice-dual-source-ct-with-low-concentration-contrast-agent-initial-experience
#17
Lei Zhao, Aishi Liu, Youmin Guo
PURPOSE: To optimize and evaluate an ultra-low-dose (ULD) technique for CT coronary angiography (CTCA). MATERIALS AND METHODS: Eighty-two patients were randomly divided into two groups. ULD and routine CTCA were performed in groups A and B. Image quality, radiation dose and contrast agent were evaluated. RESULTS: The effective dose (ED) was 0.20 ± 0.01 mSv for the ULD technique, a decrease of 87% (t = - 21.182, P < 0.001) compared with the control group...
December 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29051477/low-kv-and-low-concentration-contrast-agent-with-iterative-reconstruction-of-computed-tomography-ct-coronary-angiography-a-preliminary-study
#18
Hong Zhang, Yanhe Ma, Jun Lyu, Yapeng Yang, Wei Yuan, Zhenchun Song
BACKGROUND The aim of this study was to evaluate the image quality and radiation dose of CT coronary angiography (CTCA) with low kV, low concentration contrast agent, and iterative reconstruction. MATERIAL AND METHODS Ninety cases were randomly divided into 3 groups according to contrast agent concentration: group A 270 mg/ml (100 kV), group B 350 mg/ml (120 kV), and group C 370 mg/ml (120 kV), with 30 cases per group. Tube current was 200-250 mAs. Collimator width was 128×0.6 mm. Rotation speed was 0.27 s...
October 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28871240/in-vivo-and-in-vitro-analysis-in-coronary-artery-disease-related-to-type-2-diabetes
#19
Teresa Infante, Ernesto Forte, Marco Aiello, Marco Salvatore, Carlo Cavaliere
AIM: The leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occurs in diabetic patients, the relationship between cardiovascular disorders and DM is not fully understood. We have performed both an in vivo imaging and in vitro molecular analysis to investigate diabetic-specific CAD alterations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28844992/diagnostic-and-prognostic-benefits-of-computed-tomography-coronary-angiography-using-the-2016-national-institute-for-health-and-care-excellence-guidance-within-a-randomised-trial
#20
Philip D Adamson, Amanda Hunter, Michelle C Williams, Anoop S V Shah, David A McAllister, Tania A Pawade, Marc R Dweck, Nicholas L Mills, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin J R van Beek, Adam D Timmis, David E Newby
OBJECTIVES: To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina. METHODS: Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations...
February 2018: Heart: Official Journal of the British Cardiac Society
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