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https://www.readbyqxmd.com/read/27913900/bone-mineral-density-of-extremities-is-associated-with-coronary-calcification-and-biopsy-verified-vascular-calcification-in-living-donor-renal-transplant-recipients
#1
Zhimin Chen, Jia Sun, Mathias Haarhaus, Peter Barany, Lars Wennberg, Jonaz Ripsweden, Torkel B Brismar, Bengt Lindholm, Annika Wernerson, Magnus Söderberg, Peter Stenvinkel, Abdul Rashid Qureshi
Chronic kidney disease (CKD) mineral and bone disorders (CKD-MBD) may lead to low bone mineral density (BMD) and vascular calcification (VC), but links to the latter are unclear. Here we investigated associations between BMD, coronary artery calcium (CAC) scores, and histological signs of VC in end-stage renal disease (ESRD) patients undergoing living-donor kidney transplantation (LD-Rtx). In 66 ESRD patients (median age 45 years, 68% males), BMD (by dual-energy X-ray absorptiometry, DXA), CAC score (by computed tomography, CT; n = 54), and degree of VC score (graded by histological examination of epigastric artery specimens collected at LD-Rtx; n = 55) were assessed at the time of LD-Rtx...
December 2, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27906915/the-value-of-ct-cardiac-angiography-and-ct-calcium-score-testing-in-a-modern-cardiology-service-in-new-zealand-a-report-of-a-single-centre-eight-year-experience-from-5-237-outpatient-procedures
#2
Chris Ellis, Greg Gamble, Colin Edwards, Niels van Pelt, Ruvin Gabriel, Boris Lowe, Jonathan Christiansen, Andrew To, Helen Winch, Mark Osborne, John Ormiston, Malcolm Legget
BACKGROUND: Computed tomographic (CT) cardiac angiography is of increasing value in several areas of patient management in cardiology. We assessed the ability of CT cardiac angiography to effectively 'rule out' severe coronary stenoses in patients presenting with 'atypical' symptoms and/or an equivocal stress test, which offers a new approach to the management of coronary artery disease. We also examined the use of the CT calcium score test in cardiovascular (CVS) risk assessment. METHODS: From a large single centre (Mercy Hospital) in Auckland, using a prospectively acquired, comprehensive database, we audited the entire eight-year experience of 5,169 patients (7/8/06 to 31/1/14) who underwent 5,237 64-slice computed tomographic (CT) cardiac angiogram or CT calcium score tests (GE Lightspeed scanner)...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27898257/assessment-of-nifedipine-therapy-in-hyperinsulinemic-hypoglycemia-due-to-mutations-in-the-abcc8-gene
#3
M Güemes, P Shah, S Silvera, K Morgan, C Gilbert, L Hinchey, K Hussain
CONTEXT: Previous case reports have documented the effectiveness of L-type calcium channel blockers (such as Nifedipine and Verapamil) for treating different forms of hyperinsulinemic hypoglycemia (HH). OBJECTIVE: To systematically assess the glycemic response to Nifedipine therapy in 11 patients with HH due to mutations in the ABCC8 gene. DESIGN: Dose escalation of Nifedipine therapy Setting: Inpatients at a tertiary hospital Patients or Other Participants: 11 children with diazoxide unresponsive HH due to mutations in the ABCC8 gene...
November 29, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27896877/flavonoids-of-herba-epimedii-enhances-bone-repair-in-a-rabbit-model-of-chronic-osteomyelitis-during-post-infection-treatment-and-stimulates-osteoblast-proliferation-in-vitro
#4
Dan Shou, Yang Zhang, Lifeng Shen, Rongzong Zheng, Xiaowen Huang, Zhujun Mao, Zhongming Yu, Nani Wang, Yan Zhu
Flavonoids are the active component of the Herba Epimedii (H. Epimedii), which is commonly used in Asia. This study is to investigate the effect of H. Epimedii on bone repair after anti-infection treatment in vivo. The bioactive-composition group of H. Epimedii (BCGE) contained four flavonoids with the total content of 43.34%. Rabbits with chronic osteomyelitis in response to injection with Staphylococcus aureus were treated with BCGE of 242.70 mg/kg/day intragastrically after vancomycin-calcium sulphate treatment...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27889939/the-performance-of-cpc-plga-and-bio-oss-%C3%A2-for-bone-regeneration-in-healthy-and-osteoporotic-rats
#5
Claire I A van Houdt, Dietmar J O Ulrich, John A Jansen, Jeroen J J P van den Beucken
The current study aimed to evaluate the biological performance of calcium phosphate cement (CPC) with polylactic-co-glycolic acid (PLGA) micro-particles and Bio-Oss(®) in ovariectomized and healthy rats. Thirty-two Wistar rats received alternating experimental CPC/PLGA and Bio-Oss(®) in femoral condyle defects in both femurs 6 weeks after ovariectomy (OVX, n = 16) or sham operation (SHAM, n = 16). Six weeks after OVX or SHAM surgery, bone morphology was analyzed by in vivo computed tomography (CT) to confirm osteoporotic bone condition...
November 27, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27884729/rationale-and-design-of-the-coronary-artery-calcium-consortium-a-multicenter-cohort-study
#6
Michael J Blaha, Seamus P Whelton, Mahmoud Al Rifai, Zeina A Dardari, Leslee J Shaw, Mouaz H Al-Mallah, Kuni Matsushita, John A Rumberger, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir
BACKGROUND: Although coronary artery calcium (CAC) has been investigated for over two decades, there is very limited data on the association of CAC with cause of death. The CAC Consortium is a large ongoing multi-center observational cohort of individuals who underwent non-contrast cardiac-gated CAC testing and systematic, prospective, long-term follow-up for mortality with ascertainment of cause of death. METHODS: Four participating institutions from three states within the US (California, Minnesota, and Ohio) have contributed individual-level patient data to the CAC Consortium (spanning years 1991-2010)...
November 11, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27884644/evaluating-augmentation-with-calcium-phosphate-cement-chronos-inject-for-bone-defects-after-internal-fixation-of-proximal-tibial-fractures-a-prospective-multi-center-observational-study
#7
Ki Chul Park, Chang-Wug Oh, Young-Hoon Jo
INTRODUCTION: Managing subchondral bone defects in proximal tibia fractures after plateau reduction is an important consideration.ChronOSInjectis a recently developed calcium phosphate bone substitute that shows relatively fast osteointegration. HYPOTHESIS: UsingchronOS Inject during internal fixation of proximal tibial fractures provides a satisfactory treatment option that is both clinically and radiologically safe. MATERIALS AND METHODS: Patients enrolled in this study were treated with ChronOS Injectbone void filler, during internal fixation of proximal tibial fractures...
November 21, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27883201/effect-of-treatment-with-5-lipoxygenase-inhibitor-via-2291-atreleuton-on-coronary-plaque-progression-a-serial-ct-angiography-study
#8
Suguru Matsumoto, Reda Ibrahim, Jean C Grégoire, Philippe L L'Allier, Josephine Pressacco, Jean-Claude Tardif, Matthew J Budoff
BACKGROUND: Inflammation has a key role in the process of atherosclerosis. Production of leukotrienes by 5-lipoxygenase has been linked to atherosclerotic plaques and cardiovascular events. HYPOTHESIS: In this study, a selective 5-LO inhibitor will slow plaque progression using serial cardiac computed tomographic angiography (CCTA). METHODS: Patients with recent acute coronary syndrome (ACS) were prospectively assigned to one of 3 VIA-2291 doses (25 mg, 50 mg, 100 mg) or placebo by oral administration...
November 24, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27882428/progression-of-noncalcified-and-calcified-coronary-plaque-by-ct-angiography-in-sle
#9
Aisha Khan, Armin Arbab-Zadeh, Adnan N Kiani, Laurence S Magder, Michelle Petri
Premature coronary artery disease remains the major cause of late death in systemic lupus erythematosus (SLE). Coronary artery calcium (CAC) represents an advanced stage of atherosclerosis, whereas noncalcified coronary atherosclerotic plaque (NCP) typically is more prone to trigger acute coronary events. The aim of this study was to assess the stability of NCP over time and identify factors associated with changes in NCP in patients with SLE. CT coronary angiography and calcium scanning were performed at baseline and follow-up in thirty-six SLE patients...
November 23, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27882093/atherosclerotic-coronary-artery-disease-the-accuracy-of-measures-to-diagnose-preclinical-atherosclerosis
#10
Xianchi Li, Min Liu, Rongrong Sun, Yi Zeng, Shuang Chen, Peiying Zhang
Different methods can be used to diagnose early pre-clinical stage atherosclerosis. The present study was carried out to evaluate the efficiency of these methods. Measures including carotid intima-media thickness (CIMT), pulse wave velocity (PWV), and coronary calcium score (CCS) were evalutated for the detection of coronary artery disease (CAD). We studied the clinical and biochemical profiles of individuals with non-CAD and CAD to assess measures of pre-clinical atherosclerosis. The association between CIMT, PWV and CCS on the one hand, and the coronary atherosclerosis on the other, was studied...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27875338/an-image-domain-contrast-material-extraction-method-for-dual-energy-computed-tomography
#11
Jack W Lambert, Yuxin Sun, Robert G Gould, Michael A Ohliger, Zhixi Li, Benjamin M Yeh
OBJECTIVES: Conventional material decomposition techniques for dual-energy computed tomography (CT) assume mass or volume conservation, where the CT number of each voxel is fully assigned to predefined materials. We present an image-domain contrast material extraction process (CMEP) method that preferentially extracts contrast-producing materials while leaving the remaining image intact. MATERIALS AND METHODS: Image processing freeware (Fiji) is used to perform consecutive arithmetic operations on a dual-energy ratio map to generate masks, which are then applied to the original images to generate material-specific images...
November 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27871820/enhanced-bone-formation-in-sheep-vertebral-bodies-after-minimally-invasive-treatment-with-a-novel-plga-fiber-reinforced-brushite-cement
#12
Stefan Maenz, Olaf Brinkmann, Elke Kunisch, Victoria Horbert, Francesca Gunnella, Sabine Bischoff, Harald Schubert, Andre Sachse, Long Xin, Jens Günster, Bernhard Illerhaus, Klaus D Jandt, Jörg Bossert, Raimund W Kinne, Matthias Bungartz
BACKGROUND: Injectable, brushite-forming calcium phosphate cements (CPC) show potential for bone replacement, but they exhibit low mechanical strength. This study tested a CPC reinforced with poly (l-lactide-co-glycolide) acid (PLGA) fibers in a minimally-invasive, sheep lumbar vertebroplasty model. PURPOSE: To test the in vivo biocompatibility and osteogenic potential of a PLGA fiber-reinforced, brushite-forming CPC in a sheep large animal model. STUDY DESIGN/SETTING: Prospective experimental animal study METHODS: Bone defects (diameter 5 mm) were placed in aged, osteopenic female sheep and left empty (L2) or injected with pure CPC (L3) or PLGA-fiber-reinforced CPC (L4; fiber diameter 25 µm; length 1 mm; 10% (w/w))...
November 15, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27852512/the-association-of-secondhand-tobacco-smoke-and-ct-angiography-verified-coronary-atherosclerosis
#13
David F Yankelevitz, Matthew D Cham, Harvey Hecht, Rowena Yip, Joseph Shemesh, Jagat Narula, Claudia I Henschke
OBJECTIVES: The aim of this study was to assess the relationship of the extent of atherosclerosis on coronary computed tomographic angiography to the extent of secondhand tobacco smoke (SHTS) exposure in asymptomatic never smokers. BACKGROUND: A dose-related association between SHTS and coronary artery calcium has been reported, but the total extent of atherosclerosis has not been investigated. METHODS: Two hundred sixty-eight never smokers, ages 40 to 80 years, completed a questionnaire assessing risk factors and extent of lifetime SHTS exposure, providing a total SHTS exposure score...
November 5, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27849180/calcium-enhances-bile-salt-dependent-virulence-activation-in-vibrio-cholerae
#14
Amanda J Hay, Menghua Yang, Xiaoyun Xia, Zhi Liu, Justin Hammons, William Fenical, Jun Zhu
Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but also persists in aquatic environments where it displays an expression profile that is distinct from that during infection. Upon entry into the host, a tightly regulated circuit coordinates induction of two major virulence factors: cholera toxin (CT) and a toxin co-regulated pilus (TCP). It has been shown that a set of bile salts, including taurocholate (TC), serve as host signals to activate V. cholerae virulence through inducing the activity of a transmembrane virulence regulator TcpP...
November 14, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27846001/unexpected-diffuse-18f-naf-uptake-in-the-lung-parenchyma-in-a-patient-with-severe-hypercalcemia-due-to-myelomatosis
#15
Ali Asmar, Lene Simonsen, Birgitte Svolgaard, Jens Bülow
An 84-year-old man was admitted to the intensive care unit because of hypercalcemic crisis leading to acute renal failure needing dialysis. The patient had no other history of illness. However, because prostate-specific antigen levels were increased, the patient was referred to F-NaF PET/CT on suspicion of active skeletal metastases. The patient was finally diagnosed with myelomatosis. Although the skeletal uptake of F-NaF was without signs of focal metastasis, the F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis...
November 11, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27844188/correlation-and-predictive-value-of-aortic-root-calcification-markers-with-coronary-artery-calcification-and-obstructive-coronary-artery-disease
#16
Christian Tesche, Carlo N De Cecco, Andrew Stubenrauch, Brian E Jacobs, Akos Varga-Szemes, Sheldon E Litwin, B Devon Ball, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R Bayer, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
OBJECTIVE: To evaluate the correlation between aortic root calcification (ARC) markers and coronary artery calcification (CAC) derived from coronary artery calcium scoring (CACS) and their ability to predict obstructive coronary artery disease (CAD). METHODS: We retrospectively analyzed 189 patients (47% male, age 60.3 ± 11.1 years) with an intermediate probability of CAD who underwent clinically indicated CACS and coronary CT angiography (CCTA). ARC markers [aortic root calcium score (ARCS) and volume (ARCV)] were calculated and compared to CAC markers: coronary artery calcium score (CACS), volume (CACV), and mass (CACM)...
November 14, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27843187/coronary-ct-angiography-a-retrospective-study-of-220-cases
#17
V K Maurya, R Ravikumar, Pankaj Sharma, Naveen Agrawal, Mukul Bhatia
BACKGROUND: Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Although catheter coronary angiography (CCA) is the gold standard in the diagnosis and management of CAD, coronary CT angiography (CCTA) has shown promising results for the same. METHODS: CCTA was done using 40 slice multi-detector CT (Somatom Sensation, Siemens, Germany) machine in 220 patients of suspected CAD. Patients were classified as (a) normal (no calcific or soft plaque), (b) non-obstructive coronary disease (<50% stenosis), (c) obstructive coronary disease (>50% stenosis), or (d) a non-diagnostic study...
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27831902/local-and-transient-gene-expression-primes-the-liver-to-resist-cancer-metastasis
#18
Tyler J Goodwin, Yingqiu Zhou, Sara N Musetti, Rihe Liu, Leaf Huang
The liver is the primary site of metastasis for gastrointestinal cancers and is a location highly susceptible to the establishment of metastasis in numerous other primary cancers, including breast, lung, and pancreatic cancers. The current standard of care typically consists of primary tumor resection and systemic administration of potent but toxic chemotherapeutics, yielding a minimal improvement in the median survival rate. CXCL12, a chemokine, is a key factor for activating the migration/survival pathways of CXCR4(+) cancer cells and for recruiting immunosuppressive cells to areas of inflammation...
November 9, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27830022/transplantation-of-bone-marrow-derived-mesenchymal-stem-cells-rescues-partially-rachitic-phenotypes-induced-by-1-25-dihydroxyvitamin-d-deficiency-in-mice
#19
Zengli Zhang, Shaomeng Yin, Xian Xue, Ji Ji, Jian Tong, David Goltzman, Dengshun Miao
To determine whether the transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) can improve the 1,25(OH)2D deficiency-induced rachitic phenotype, 2×10(6) BM-MSCs from wild-type mice or vehicle were transplanted by tail vein injection into mice deficient in 1,25(OH)2D due to targeted deletion of 1α(OH)ase (1α(OH)ase(-/-)). Our results show that 1α(OH)ase mRNA was expressed in the BM-MSCs derived from wild-type mice, and was detected in long bone, kidney and intestine from BM-MSC-transplanted 1α(OH)ase(-/-) recipients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27824692/long-term-marathon-running-is-associated-with-low-coronary-plaque-formation-in-women
#20
William O Roberts, Robert S Schwartz, Stacia Merkel Kraus, Jonathan G Schwartz, Gretchen Peichel, Ross F Garberich, John R Lesser, Stephen N Oesterle, Kelly K Wickstrom, Thomas Knickelbine, Kevin M Harris
INTRODUCTION: Marathon running is presumed to improve cardiovascular risk, but health benefits of high volume running are unknown. High resolution coronary computed tomography angiography (CCTA) and a cardiac risk factor assessment were completed in women with long term marathon running histories to compare to sedentary women with similar risk factors. METHODS: Women who had run at least one marathon per year for 10-25 years underwent CCTA, 12-lead ECG, blood pressure and heart rate measurement, lipid panel, and a demographic/health risk factor survey...
November 7, 2016: Medicine and Science in Sports and Exercise
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