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https://www.readbyqxmd.com/read/28425622/targeted-disruption-of-nf1-in-osteocyte-increases-fgf23-and-osteoid-with-osteomalacia-like-bone-phenotype
#1
Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Audrey Kim, Gen Kuroyanagi, Matthew Phipps, Naga Suresh Adapala, Jian Q Feng, Harry K W Kim
Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi-system abnormalities including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the protein product of the NF1 gene, in osteocytes is largely unknown. This study investigated the role of neurofibromin in osteocytes by disrupting Nf1 under the Dmp1-promoter. The conditional knockout (Nf1 cKO) mice displayed serum profile of a metabolic bone disorder with an osteomalacia-like bone phenotype...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28414187/metatropic-dysplasia-in-third-trimester-of-pregnancy-and-a-novel-causative-variant-in-the-trpv4-gene
#2
Sara Bargiacchi, Matteo Della Monica, Roberto Biagiotti, Elena Andreucci, Serena Ciabattoni, Paolo Poggi, Marco Di Maurizio, Claudio Defilippi, Ettore Cariati, Sabrina Giglio
Prenatal diagnosis of skeletal dysplasias is particularly difficult for many reasons and differentiating these disorders in the prenatal period can be challenging because they are rare and many of the ultrasound findings are not necessarily pathognomonic for a specific disorder. The diagnosis is often made just after birth or exitus. The prenatal diagnosis of osteochondrodysplasias is based predominantly upon fetal ultrasound findings and it focuses substantially on the possible lethality of the disorder, without always being able to find a specific name for the disorder...
April 13, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28413071/performance-of-ultra-low-dose-ct-for-the-evaluation-of-coronary-calcification-a-direct-comparison-with-coronary-calcium-score
#3
V V Silveira de Souza, F Soares Torres, B Hochhegger, G Watte, G Sartori, F Lucchese, B Azambuja Gonçalves
AIM: To evaluate the diagnostic performance of ultra-low-dose computed tomography (ULDCT) in comparison to standard coronary calcium score (CCS) acquisition for the evaluation of coronary artery calcification (CAC). MATERIALS AND METHODS: Standard CCS acquisition and ULDCT were performed in patients referred for coronary CT angiography for the evaluation of coronary artery disease. CAC in ULDCT was graded subjectively using a four-point scale (from 0, no calcification, to 3, severe calcification) for the complete study and for each individual coronary segment...
April 13, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28411031/prognostic-value-of-visually-detected-coronary-artery-calcification-on-unenhanced-non-gated-thoracic-computed-tomography-for-prediction-of-non-fatal-myocardial-infarction-and-all-cause-mortality
#4
Lisa Shao, Andrew T Yan, Gerald Lebovic, Harvey H Wong, Anish Kirpalani, Djeven P Deva
PURPOSE: To determine the prognostic value of visually detected coronary artery calcification (CAC) on unenhanced non-gated thoracic computed tomography (CT) for non-fatal myocardial infarction (MI) and all-cause mortality. METHODS: This retrospective single-centre cohort study comprised of 410 consecutive patients aged 40-80 years without any known cardiovascular disease at baseline. CT images without electrocardiogram-gating were acquired for a variety of respiratory medicine indications...
March 28, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28401593/low-dose-bmp-2-and-msc-dual-delivery-onto-coral-scaffold-for-critical-size-bone-defect-regeneration-in-sheep
#5
Adeline Decambron, Alexandre Fournet, Morad Bensidhoum, Mathieu Manassero, Frédéric Sailhan, Hervé Petite, Delphine Logeart-Avramoglou, Véronique Viateau
Tissue-engineered constructs (TECs) combining resorbable calcium-based scaffolds and mesenchymal stem cells (MSCs) have the capability to regenerate large bone defects. Inconsistent results have, however, been observed, with a lack of osteoinductivity as a possible cause of failure. This study aimed to evaluate the impact of the addition of low-dose bone morphogenetic protein-2 (BMP-2) to MSC-coral-TECs on the healing of clinically-relevant segmental bone defects in sheep. Coral granules were either seeded with autologous MSCs (bone marrow-derived) or loaded with BMP-2...
April 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28395916/strengths-and-limitations-of-coronary-angiography-with-turbo-high-pitch-third-generation-dual-source-ct
#6
M M Ochs, F Andre, G Korosoglou, T Fritz, S Seitz, Y Bogomazov, C L Schlett, R Sokiranski, A Sommer, F Gückel, M Brado, H-U Kauczor, J Görich, H A Katus, S J Buss
AIM: To define practical limitations of diagnostic image quality for recently introduced turbo high-pitch scan mode (THP) in third-generation dual-source computed tomography (CT). MATERIALS AND METHODS: Two hundred and twenty-nine consecutive patients undergoing CT coronary angiography were included in this retrospective single-centre analysis. A contrast-enhanced volume dataset was acquired in THP. Image quality of coronary segments was classified as diagnostic or non-diagnostic by three blinded readers...
April 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28390834/coronary-artery-calcium-scoring-for-ruling-out-acute-coronary-syndrome-in-chest-pain-ct
#7
Ricarda Hinzpeter, Kai Higashigaito, Fabian Morsbach, David Benz, Robert Manka, Burkhardt Seifert, Dagmar I Keller, Hatem Alkadhi
No abstract text is available yet for this article.
March 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28386853/assessment-of-bone-regeneration-of-a-tissue-engineered-bone-complex-using-human-dental-pulp-stem-cells-poly-%C3%AE%C2%B5-caprolactone-biphasic-calcium-phosphate-scaffold-constructs-in-rabbit-calvarial-defects
#8
Natkrita Wongsupa, Thongchai Nuntanaranont, Suttatip Kamolmattayakul, Nuttawut Thuaksuban
The objective of the present study was to investigate the effect of a fabricated combination of poly-ɛ-caprolactone (PCL)-biphasic calcium phosphate (BCP) with the modified melt stretching and multilayer deposition (mMSMD) technique on human dental pulp stem cell (hDPSC) differentiation to be osteogenic like cells for bone regeneration of calvarial defects in rabbit models. hDPSCs extracted from human third molars were seeded onto mMSMD PCL-BCP scaffolds and the osteogenic gene expression was tested prior to implantation in vivo...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28385609/investigation-of-phosphorylated-adjuvants-co-encapsulated-with-a-model-cancer-peptide-antigen-for-the-treatment-of-colorectal-cancer-and-liver-metastasis
#9
Tyler J Goodwin, Leaf Huang
The lipid calcium phosphate nanoparticle is a versatile platform capable of encapsulating a wide range of phosphorylated molecules from single nucleotides to pDNA. The use of this platform has shown great success as an immunotherapeutic vaccine carrier, capable of delivering co-encapsulated phosphorylated adjuvants and peptides. Three potent vaccine formulations were investigated for anti-cancer efficacy. The phosphorylated adjuvants, CpG, 2'3'cGAMP, and 5'pppdsRNA were co-encapsulated with a model phosphorylated tumor specific peptide antigen (p-AH1-A5)...
April 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28380658/cationic-osteogenic-peptide-p15-csp-coatings-promote-3-d-osteogenesis-in-poly-epsilon-caprolactone-scaffolds-of-distinct-pore-size
#10
Xian Li, Nima Ghavidel Mehr, Jessica Guzmán-Morales, Basil D Favis, Gregory De Crescenzo, Nanda Yakandawala, Caroline D Hoemann
P15-CSP is a biomimetic cationic fusion peptide that stimulates osteogenesis and inhibits bacterial biofilm formation when coated on 2-D surfaces. This study tested the hypothesis that P15-CSP coatings enhance 3-D osteogenesis in a porous but otherwise hydrophobic poly-(ε-caprolactone) (PCL) scaffold. Scaffolds of 84 µm and 141 µm average pore size were coated or not with Layer-by-Layer polyelectrolytes followed by P15-CSP, seeded with adult primary human mesenchymal stem cells (MSCs), and cultured 10 days in proliferation medium, then 21 days in osteogenic medium...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28379388/prevalence-of-obstructive-coronary-artery-disease-and-prognosis-in-patients-with-stable-symptoms-and-a-zero-coronary-calcium-score
#11
Tarun K Mittal, Alison Pottle, Ed Nicol, Mahmoud Barbir, Ben Ariff, Saeed Mirsadraee, Michael Dubowitz, Diana A Gorog, Piers Clifford, Soroosh Firoozan, Robert Smith, Simon Dubrey, Harmeet Chana, Jaymin Shah, Nigel Stephens, Christopher Travill, Andrew Kelion, Mini Pakkal, Adam Timmis
Aims: CT calcium scoring (CTCS) and CT cardiac angiography (CTCA) are widely used in patients with stable chest pain to exclude significant coronary artery disease (CAD). We aimed to resolve uncertainty about the prevalence of obstructive coronary artery disease and long-term outcomes in patients with a zero-calcium score (ZCS). Methods and results: Consecutive patients with stable cardiac symptoms referred for CTCS or CTCS and CTCA from chest pain clinics to a tertiary cardiothoracic centre were prospectively enrolled...
March 31, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28378112/automatic-determination-of-cardiovascular-risk-by-ct-attenuation-correction-maps-in-rb-82-pet-ct
#12
Ivana Išgum, Bob D de Vos, Jelmer M Wolterink, Damini Dey, Daniel S Berman, Mathieu Rubeaux, Tim Leiner, Piotr J Slomka
BACKGROUND: We investigated fully automatic coronary artery calcium (CAC) scoring and cardiovascular disease (CVD) risk categorization from CT attenuation correction (CTAC) acquired at rest and stress during cardiac PET/CT and compared it with manual annotations in CTAC and with dedicated calcium scoring CT (CSCT). METHODS AND RESULTS: We included 133 consecutive patients undergoing myocardial perfusion (82)Rb PET/CT with the acquisition of low-dose CTAC at rest and stress...
April 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28374079/accuracy-of-bone-mineral-density-quantification-using-dual-layer-spectral-detector-ct-a-phantom-study
#13
Robbert W van Hamersvelt, Arnold M R Schilham, Klaus Engelke, Annemarie M den Harder, Bart de Keizer, Harald J Verhaar, Tim Leiner, Pim A de Jong, Martin J Willemink
OBJECTIVES: To investigate the accuracy of bone mineral density (BMD) quantification using dual-layer spectral detector CT (SDCT) at various scan protocols. METHODS: Two validated anthropomorphic phantoms containing inserts of 50-200 mg/cm(3) calcium hydroxyapatite (HA) were scanned using a 64-slice SDCT scanner at various acquisition protocols (120 and 140 kVp, and 50, 100 and 200 mAs). Regions of interest (ROIs) were placed in each insert and mean attenuation profiles at monochromatic energy levels (90-200 keV) were constructed...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28370026/the-effect-of-mixing-method-on-tricalcium-silicate-based-cement
#14
J A Duque, S L Fernandes, J P Bubola, M A H Duarte, J Camilleri, M A Marciano
AIM: To evaluate the effect of three methods of mixing on the physical and chemical properties of tricalcium silicate-based cements. METHODOLOGY: The materials evaluated were MTA Angelus and Portland cement with 20% zirconium oxide (PC-20-Zr). The cements were mixed using a 3:1 powder to liquid ratio. The mixing methods were: manual (m), trituration (tr) and ultrasonic (us) activation. The materials were characterized by means of scanning electron microscope (SEM) and energy dispersive x-ray spectroscopy (EDS)...
March 30, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28368527/analysis-of-recurrent-stenosis-after-carotid-endarterectomy-featuring-primary-plaque-calcification
#15
Hiroyuki Katano, Mitsuhito Mase, Yusuke Nishikawa, Hiroshi Yamada, Kazuo Yamada
BACKGROUND: The relationship between calcification in primary plaque and restenosis after carotid endarterectomy (CEA) has been seldom investigated. OBJECTIVE: To clarify the relationship between characteristics of calcified carotid plaque and recurrent stenosis after CEA, as well as the disease's natural course. METHODS: Ninety-four plaques out of 107 consecutive CEAs were retrospectively analyzed with regard to calcification, employing calcium score as well as shape, location, and other characteristics of original plaques...
March 23, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28366859/degradation-behavior-and-compatibility-of-micro-nanoha-chitosan-scaffolds-with-interconnected-spherical-macropores
#16
Li Ruixin, Xu Cheng, Liu Yingjie, Li Hao, Shi Caihong, Su Weihua, An Weining, Yuan Yinghai, Qin Xiaoli, Xu Yunqiang, Zhang Xizheng, Li Hui
Hydroxyapatite/Chitosan (HA/CS) composite have significant application in biomedical especially for bone replacement. Inorganic particle shape and size of composite affect the scaffold mechanical property, biological property, and degradation. The aim of this study was to fabricate HA/CS scaffold with good pore connectivity and analyze their biological, degradation properties. Microhydroxyapatite/chitosan(mHA/CS) and nanohydroxyapatite/chitosan (nHA/CS) composite scaffolds with interconnected spherical pore architectures were fabricated...
March 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28366425/osteoporosis-in-the-women-s-health-initiative-another-treatment-gap
#17
Maryam Sattari, Jane A Cauley, Cynthia Garvan, Karen C Johnson, Michael J LaMonte, Wenjun Li, Marian Limacher, Todd Manini, Gloria E Sarto, Shannon D Sullivan, Jean Wactawski-Wende, Rebecca J Beyth
BACKGROUND: Osteoporotic fractures are associated with high morbidity, mortality, and cost. METHODS: We performed a post hoc analysis of the Women's Health Initiative (WHI) clinical trials (CT) data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis and/or fracture. Information from visits prior to and immediately subsequent to the first fracture event or osteoporosis diagnosis were evaluated for medication use...
March 30, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28364395/severe-and-asymptomatic-aortic-stenosis-management-challenge-knowing-that-we-do-not-really-know
#18
REVIEW
Lionel Tastet, Louis Simard, Marie-Annick Clavel
The clinical management of asymptomatic patients with severe aortic valve stenosis (AS) may be challenging. Indeed, there is substantial controversy over the optimal timing of intervention for these patients, as some advocate early intervention while others urge for a conservative management until symptom onset. In the meantime of randomized clinical trials aiming to compare both strategies of management, an integrative approach including several imaging modalities as well as biomarkers of the myocardial damage may help to improve the risk stratification of patients with asymptomatic severe AS and individualize strategy of treatment...
May 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28361831/evolving-management-of-insulinoma-experience-at-a-tertiary-care-centre
#19
Viveka P Jyotsna, Sujoy Pal, D Kandasamy, S Gamanagatti, P K Garg, N Raizada, Peush Sahni, C S Bal, N Tandon, A C Ammini
BACKGROUND & OBJECTIVES: Since our previous study in 2006, several new modalities for localization of cause of endogenous hyperinsulinemic hypoglycaemia such as multiphasic computed tomography (CT), multiphasic magnetic resonance imaging (MRI), endoscopic ultrasound (EUS), intraoperative ultrasound, and intra-arterial calcium infusion with arterial stimulation venous sampling (ASVS) have become available. Therefore, to evaluate the relative usefulness of various imaging modalities to guide future management in terms of diagnosis and patient care, we analyzed presentation and management of patients of endogenous hyperinsulinemic hypoglycaemia...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28357643/raloxifene-but-not-alendronate-can-compensate-the-impaired-osseointegration-in-osteoporotic-rats
#20
Leonardo Perez Faverani, Tárik Ocon Braga Polo, Gabriel Ramalho-Ferreira, Gustavo Antonio Correa Momesso, Jaqueline Suemi Hassumi, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Felippe Bevilacqua Prado, Eloá Rodrigues Luvizuto, Reinhard Gruber, Roberta Okamoto
OBJECTIVES: Alendronate and raloxifene, a bisphosphonate and a selective estrogen modulator, respectively, are established osteoporosis therapies. Current evidence suggests that simultaneous application of osteoporosis therapies modulates osseointegration. However, alendronate shows inconsistent findings and raloxifene has not been studied comprehensively. This study aimed to evaluate the bone dynamics and molecular and microstructural features at the peri-implant bone interface in osteoporotic rats...
March 29, 2017: Clinical Oral Investigations
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