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https://www.readbyqxmd.com/read/28103657/-a-case-of-primary-hyperparathyroidism-complicated-with-hypercalcemic-crisis-during-treatment-with-cinacalcet-and-improved-by-active-treatment
#1
Tomoki Takeda, Atsushi Okada, Rei Unno, Yukihiro Umemoto, Keiichi Tozawa, Takahiro Yasui
A 77-year-old man was referred to our department for surgical treatment of a right ureteral stone identified on computed tomography (CT) during intensive examination for spondylolisthesis of L4-L5. At the initial visit, performance status was 4, and renal dysfunction was identified (Cr 1.3 mg/dl). Corrected calcium level was 11.8 mg/dl, and intact parathyroid hormone level was 555 pg/ml. A CT scan showed a well-defined mass measuring 22×16×20 mm on the right side of the esophagus, along with 99mTc-MIBI uptake in the lesion...
December 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28102510/influence-of-dose-reduction-and-iterative-reconstruction-on-ct-calcium-scores-a-multi-manufacturer-dynamic-phantom-study
#2
N R van der Werf, M J Willemink, T P Willems, M J W Greuter, T Leiner
To evaluate the influence of dose reduction in combination with iterative reconstruction (IR) on coronary calcium scores (CCS) in a dynamic phantom on state-of-the-art CT systems from different manufacturers. Calcified inserts in an anthropomorphic chest phantom were translated at 20 mm/s corresponding to heart rates between 60 and 75 bpm. The inserts were scanned five times with routinely used CCS protocols at reference dose and 40 and 80% dose reduction on four high-end CT systems. Filtered back projection (FBP) and increasing levels of IR were applied...
January 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28095950/ct-coronary-angiography-vs-coronary-artery-calcium-scoring-for-the-occupational-assessment-of-military-aircrew
#3
Iain Parsons, Chris Pavitt, Rebecca Chamley, Jo d'Arcy, Ed Nicol
INTRODUCTION: To ensure flight safety military aircrew undergo regular clinical and occupational assessment. Coronary artery calcium scoring (CACS) has been established as an imaging modality to noninvasively assess coronary artery disease (CAD). CT coronary angiography (CTCA) potentially offers a more accurate assessment of CAD, but has not been formally assessed in military aircrew. This retrospective cohort study is designed to compare the theoretical differences in downstream investigations and occupational outcomes in aircrew with suspected CAD comparing CTCA with existing CACS pathways...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28088646/bone-microarchitecture-in-adolescent-boys-with-autism-spectrum-disorder
#4
Ann M Neumeyer, Natalia Cano Sokoloff, Erin McDonnell, Eric A Macklin, Christopher J McDougle, Madhusmita Misra
BACKGROUND: Boys with autism spectrum disorder (ASD) have lower areal bone mineral density (aBMD) than typically developing controls (TDC). Studies of volumetric BMD (vBMD) and bone microarchitecture provide information about fracture risk beyond that provided by aBMD but are currently lacking in ASD. OBJECTIVES: To assess ultradistal radius and distal tibia vBMD, bone microarchitecture and strength estimates in adolescent boys with ASD compared to TDC. DESIGN/METHODS: Cross-sectional study of 34 boys (16 ASD, 18 TDC) that assessed (i) aBMD at the whole body (WB), WB less head (WBLH), hip and spine using dual X-ray absorptiometry (DXA), (ii) vBMD and bone microarchitecture at the ultradistal radius and distal tibia using high-resolution peripheral quantitative CT (HRpQCT), and (iii) bone strength estimates (stiffness and failure load) using micro-finite element analysis (FEA)...
January 11, 2017: Bone
https://www.readbyqxmd.com/read/28079789/the-impact-of-irrigating-fluid-absorption-on-blood-coagulation-in-patients-undergoing-transurethral-resection-of-the-prostate-a-prospective-observational-study-using-rotational-thromboelastometry
#5
Hyun-Jung Shin, Hyo-Seok Na, Young-Tae Jeon, Hee-Pyoung Park, Sun-Woo Nam, Jung-Won Hwang
Although endoscopic transurethral resection of the prostate (TURP) is a well-established procedure as a treatment for benign prostatic hyperplasia, its complications remain a concern. Among these, coagulopathy may be caused by the absorption of irrigating fluid. This study aimed to evaluate such phenomenon using a rotational thromboelastometry (ROTEM).A total of 20 patients undergoing TURP participated in this study. A mixture of 2.7% sorbitol-0.54% mannitol solution and 1% ethanol was used as an irrigating fluid, and fluid absorption was measured via the ethanol concentration in expired breath...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079305/gallium-enhances-reconstructive-properties-of-a-calcium-phosphate-bone-biomaterial
#6
Ivana Strazic Geljic, Nicolas Melis, Florian Boukhechba, Sébastien Schaub, Charlotte Mellier, Pascal Janvier, Jean-Pierre Laugier, Jean-Michel Bouler, Elise Verron, Jean-Claude Scimeca
Calcium phosphate-based (CaP) biomaterials are commonly used in bone reconstructive surgery to replace the damaged tissue, and can also serve as vectors for local drug delivery. Due to its inhibitory action on osteoclasts, the semi-metallic element gallium (Ga) is used for the systemic treatment of disorders associated with accelerated bone resorption. As it was demonstrated that Ga could be incorporated in the structure of CaP biomaterials, we investigated in the present work the biological properties of Ga-loaded CaP biomaterials...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28070917/dual-energy-ct-quantitative-imaging-a-comparison-study-between-twin-beam-and-dual-source-ct-scanners
#7
Isabel P Almeida, Lotte E J R Schyns, Michel C Öllers, Wouter van Elmpt, Katia Parodi, Guillaume Landry, Frank Verhaegen
PURPOSE: To assess image quality and to quantify the accuracy of relative electron densities (ρe ) and effective atomic numbers (Zeff ) for three dual-energy computed tomography (DECT) scanners: a novel single-source split-filter (i.e., twin-beam) and two dual-source scanners. METHODS: Measurements were made with a second generation dual-source scanner at 80/140Sn kVp, a third-generation twin-beam single-source scanner at 120 kVp with gold (Au) and tin (Sn) filters, and a third-generation dual-source scanner at 90/150Sn kVp...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28065376/dual-energy-ct-virtual-non-calcium-technique-for-detection-of-bone-marrow-edema-in-patients-with-vertebral-fractures-a-prospective-feasibility-study-on-a-single-source-volume-ct-scanner
#8
T Diekhoff, K G Hermann, M Pumberger, B Hamm, M Putzier, M Fuchs
OBJECTIVES: Dual-energy computed tomography (DECT) is a recent development for detecting bone marrow edema (BME) in patients with vertebral compression fractures. The aim of this pilot study was to determine the reliability of single-source DECT in detecting vertebral BME using magnetic resonance imaging (MRI) as standard of reference. MATERIALS AND METHODS: Nine patients with radiographic thoracic or lumbar vertebral compression fractures underwent both, DECT on a 320-row single-source scanner and 1...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28062302/calcitonin-typical-suppression-of-osteoclastic-activity-by-amphioxus-calcitonin-superfamily-peptides-and-insights-into-the-evolutionary-conservation-and-diversity-of-their-structures
#9
Toshio Sekiguchi, Akira Shiraishi, Honoo Satake, Kenji Kuwasako, Hiroki Takahashi, Masayuki Sato, Makoto Urata, Shuichi Wada, Masato Endo, Takahiro Ikari, Atsuhiko Hattori, Ajai K Srivastav, Nobuo Suzuki
Calcitonin (CT) is a hormone that decreases serum calcium level by suppressing osteoclastic activity in the vertebrate bone. In vertebrates, the structure-function relationship of CTs has been studied extensively. We recently identified three CT superfamily peptides, Bf-CTFP1 to 3, and clarified the molecular and functional characteristics of their receptor and receptor activity-modifying protein in amphioxus, Branchiostoma floridae. However, the CT activity of Bf-CTFPs has yet to be investigated. In the present study, a functional analysis of Bf-CTFPs was performed using goldfish scales having both osteoclasts and osteoblasts...
January 3, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28048223/we-fg-207b-06-plaque-composition-measurement-with-dual-energy-computed-tomography
#10
C Wang, H Ding, S Malkasian, S Molloi
PURPOSE: To investigate the feasibility of characterizing arterial plaque composition in terms of water, lipid and protein or calcium using dual energy computed tomography. Characterization of plaque composition can potentially help distinguish vulnerable from stable plaques. METHODS: Simulations studies were performed by the CT simulator based on ASTRA tomography toolbox. The beam energy for dual energy images was selected to be 80 kVp and 135 kVp. The radiation dose and energy spectrum for the CT simulator were carefully calibrated with respect to a 320-slice CT scanner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048045/su-f-t-171-manufacturing-cost-effective-heterogeneous-phantoms-for-use-in-proton-therapy
#11
J Pruett, Y Chen, S Ahmad, D Johnson
PURPOSE: To study the feasibility of 3D printing cost effective heterogeneous phantoms for use in proton therapy treatment planning quality assurance. METHODS: A desktop 3D printer was utilized to create a series of 2 cm × 2 cm × 4 cm PLA plastic blocks of varying fill materials and hexagonal fill pattern. The blocks were than tested when filled with air, polyurethane foam, paraffin, silicone, and caulk of calcium carbonate - acrylic polymer blend. The blocks were evaluated with a "GE Lightspeed" 16 slice CT scanner and average CT# of the materials' centers evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047792/su-c-206-01-impact-of-charge-sharing-effect-on-sub-pitch-resolution-for-czt-based-photon-counting-ct-systems
#12
X Zheng, Z Cheng, J Deen, H Peng, L Xing
PURPOSES: Photon counting CT is a new imaging technology that can provide tissue composition information such as calcium/iodine content quantification. Cadmium zinc telluride CZT is considered a good candidate the photon counting CT due to its relatively high atomic number and band gap. One potential challenge is the degradation of both spatial and energy resolution as the fine electrode pitch is deployed (<50 µm). We investigated the extent of charge sharing effect as functions of gap width, bias voltage and depth-of-interaction (DOI)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047585/su-d-206-06-task-specific-optimization-of-scintillator-thickness-for-cmos-detector-based-cone-beam-breast-ct
#13
S Vedantham, S Shrestha, L Shi, G Vijayaraghavan, A Karellas
PURPOSE: To optimize the cesium iodide (CsI:Tl) scintillator thickness in a complimentary metal-oxide semiconductor (CMOS)-based detector for use in dedicated cone-beam breast CT. METHODS: The imaging task considered was the detection of a microcalcification cluster comprising six 220µm diameter calcium carbonate spheres, arranged in the form of a regular pentagon with 2 mm spacing on its sides and a central calcification, similar to that in ACR-recommended mammography accreditation phantom, at a mean glandular dose of 4...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047135/su-c-206-02-estimating-coronary-artery-plaque-composition-with-a-combined-dual-energy-and-single-energy-qct-optimization-model
#14
M Goodsitt, H Chan, K Watcharotone, B Nan, E Christodoulou
PURPOSE: A study was performed to evaluate the accuracy of a combined dual-energy/single-energy QCT optimization model for estimating the volume fractions of fat, cholesterol, protein, fibrous tissue, and calcium in coronary artery plaque. METHODS: This model uses 80kVp-140kVp CT# data to distinguish calcium, and Gaussian component analysis based on the 140kVp CT#'s of the pure materials to distinguish the other constituents. An experimental study was performed with a thorax section phantom (CIRS, Inc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047043/we-fg-207b-12-quantitative-evaluation-of-a-spectral-ct-scanner-in-a-phantom-study-results-of-spectral-reconstructions
#15
X Duan, G Arbique, J Guild, Y Yagil, J Anderson
PURPOSE: To evaluate the quantitative image quality of spectral reconstructions of phantom data from a spectral CT scanner. METHODS: The spectral CT scanner (IQon Spectral CT, Philips Healthcare) is equipped with a dual-layer detector and generates conventional 80ߝ140 kVp images and variety of spectral reconstructions, e.g., virtual monochromatic (VM) images, virtual non-contrast (VNC) images, iodine maps, and effective atomic number (Z) images. A cylindrical solid water phantom (Gammex 472, 33 cm diameter and 5 cm thick) with iodine (2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047031/th-ef-207a-06-high-resolution-optical-ct-ect-imaging-of-unstained-mice-femur-brain-spleen-and-tumor
#16
S Yoon, M Boss, S Birer, M Dewhirst, M Oldham
PURPOSE: Optical transmission and emission computed tomography (optical-CT/ECT) provides high-resolution 3D attenuation and emission maps in unsectioned large (∼1cm(3) ) ex vivo tissue samples at a resolution of 12.9µm(3) per voxel. Here we apply optical-CT/ECT to investigate high-resolution structure and auto-fluorescence in a range of optically cleared mice organs, including, for the first time, mouse bone (femur), opening the potential for study of bone metastasis and bone-mediated immune response...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046958/th-cd-207b-10-effect-of-ct-reconstruction-filter-on-measured-hounsfield-values-in-lung-nodules
#17
K Little, I Reiser, A Sanchez, J Chung, H MacMahon, Z Lu
PURPOSE: Measured Hounsfield numbers in CT are used by radiologists to determine the presence of calcium or fat in lung nodules, either of which suggests a benign diagnosis. However, substantial variations in Hounsfield number may arise due to the use of different reconstruction parameters such as the filter/kernel, leading to measurement inaccuracies. This quality improvement project was developed to demonstrate measurement pitfalls and to identify acceptable conditions for incorporating Hounsfield values as a factor in lung nodule diagnosis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28028693/a-study-of-coronary-bifurcation-shape-in-a-normal-population
#18
Pau Medrano-Gracia, John Ormiston, Mark Webster, Susann Beier, Chris Ellis, Chunliang Wang, Örjan Smedby, Alistair Young, Brett Cowan
During percutaneous coronary intervention, stents are placed in narrowings of the arteries to restore normal blood flow. Despite improvements in stent design, deployment techniques and drug-eluting coatings, restenosis and stent thrombosis remain a significant problem. Population stent design based on statistical shape analysis may improve clinical outcomes. Computed tomographic (CT) coronary angiography scans from 211 patients with a zero calcium score, no stenoses and no intermediate artery, were used to create statistical shape models of 446 major coronary artery bifurcations (left main, first diagonal and obtuse marginal and right coronary crux)...
December 27, 2016: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28028645/comparison-of-a-calcium-phosphate-bone-substitute-with-recombinant-human-bone-morphogenetic-protein-2-a-prospective-study-of-fusion-rates-clinical-outcomes-and-complications-with-24-month-follow-up
#19
Rhiannon M Parker, Gregory M Malham
PURPOSE: Recombinant human bone morphogenetic protein-2 (rhBMP-2) generally provides high rates of clinical improvement and fusion. However, rhBMP-2 has been associated with adverse effects. Recently, a beta tricalcium phosphate (β-TCP) bone substitute has been developed. The aim of this study was to determine the fusion rates and clinical outcomes of patients treated with β-TCP compared to rhBMP-2. METHODS: One hundred and thirty-five consecutive patients who underwent lateral lumbar interbody fusion with β-TCP (n = 25) or rhBMP-2 (n = 110) in the interbody cage were included in the study...
December 27, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28028450/syntax-score-in-patients-with-high-computed-tomography-coronary-calcium-score
#20
Madhav Hegde, Ravindran Rajendran
OBJECTIVES: To study the conventional coronary angiogram ( CA) findings in patients with high coronary calcium on multidetector computed tomogram. MATERIALS AND METHODS: Fifty patients with coronary calcium high enough in its extent and location to interfere with the interpretation of a contrast-filled coronary artery for a significant lesion were studied with conventional CA. Framingham risk score (FRS), computed tomography (CT) coronary calcium score (CCS), and SYNTAX score (SS) from the CA were calculated by separate investigators who were blinded to other scores...
2016: Journal of Clinical Imaging Science
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