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https://www.readbyqxmd.com/read/28109106/-effect-of-methamphetamine-exposure-on-s-nitrosylation-of-protein-disulphide-isomerase-in-pc12-cells
#1
Xiao-Fang Wu, Ai-Feng Wang, Ping-Ming Qiu
OBJECTIVE: To study the effect of methamphetamine (METH) exposure on S-nitrosylation of protein disulphide isomerase and the neurotoxicity of METH in PC12 cells. METHODS: PC12 cells were exposed to different concentrations of METH, and the cell viability was assessed using the cell-counting kit-8. PC12 cells exposed to METH in the presence of the NOS inhibitor N-nitro-L-arginine (L-NNA) were examined for cell viability and S-nitrosylation of protein disulphide isomerase using the biotin-switch method, and the changes in cell morphology were examined with HE staining...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28107969/a-new-paper-based-analytical-device-for-detection-of-glucose-6-phosphate-dehydrogenase-deficiency
#2
Phuritat Kaewarsa, Wanida Laiwattanapaisal, Attakorn Palasuwan, Duangdao Palasuwan
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic haemolytic disorder. Most persons with G6PD deficiency are asymptomatic, but exposure to oxidant drugs, such as the anti-malarial drug primaquine, may induce haemolysis, which is commonly found in Asian countries. A reliable test is necessary for diagnosing the deficiency to prevent an acute haemolytic crisis. This study proposes a novel quantitative method to detect G6PD deficiency using paper-based analytical devices (G6PDD-PAD). Wax printing was utilized for fabricating circular reaction zone patterns in paper...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107724/effect-of-sole-or-combined-administration-of-nitrate-and-3-nitro-1-propionic-acid-on-fermentation-and-salmonella-survivability-in-alfalfa-fed-rumen-cultures-in-vitro
#3
Alejandro Castañeda Correa, Julian Trachsel, Heather K Allen, Agustin Corral-Luna, Hector Gutierrez-Bañuelos, Pedro Antonia Ochoa-Garcia, Oscar Ruiz-Barrera, Michael E Hume, Todd R Callaway, Roger B Harvey, Ross C Beier, Robin C Anderson, David J Nisbet
Ruminal methanogenesis is a digestive inefficiency resulting in the loss of dietary energy consumed by the host and contributing to environmental methane emission. Nitrate is being investigated as a feed supplement to reduce rumen methane emissions but safety and efficacy concerns persist. To assess potential synergies of co-administering sub-toxic amounts of nitrate and 3-nitro-1-propionate (NPA) on fermentation and Salmonella survivability with an alfalfa-based diet, ruminal microbes were cultured with additions of 8 or 16mM nitrate, 4 or 12mM NPA or their combinations...
January 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28104576/nitro-fatty-acids-in-plant-signaling-new-key-mediators-of-nitric-oxide-metabolism
#4
REVIEW
Capilla Mata-Pérez, Beatriz Sánchez-Calvo, María N Padilla, Juan C Begara-Morales, Raquel Valderrama, Francisco J Corpas, Juan B Barroso
Recent studies in animal systems have shown that NO can interact with fatty acids to generate nitro-fatty acids (NO2-FAs). They are the product of the reaction between reactive nitrogen species and unsaturated fatty acids, and are considered novel mediators of cell signaling based mainly on a proven anti-inflammatory response. Although these signaling mediators have been described widely in animal systems, NO2-FAs have scarcely been studied in plants. Preliminary data have revealed the endogenous presence of free and protein-adducted NO2-FAs in extra-virgin olive oil (EVOO), which appear to be contributing to the cardiovascular benefits associated with the Mediterranean diet...
January 10, 2017: Redox Biology
https://www.readbyqxmd.com/read/28101797/ni-ii-and-zn-ii-complexes-containing-alkynyl-functionalized-salicylaldimine-ligand-and-heterocyclic-coligand-synthesis-characterization-and-luminescence-properties
#5
M S More, S S Devkule, S S Chavan
Some nickel(II) and zinc(II) complexes of the type [Ni(L)(phen/bipy)]X (1a-6a) and [Zn(L) (phen/bipy)]X (1b-6b) (where L = 2-{(E)-[(4-trimethylsilylethynylphenyl)imino]methyl}-4-(4-nitro phenylethynyl)phenol; phen = 1, 10-phenanthroline, bipy = 2, 2´-bipyridine; X = ClO4(-), BF4(-), PF6(-)) have been prepared and characterized on the basis of elemental analyses, FTIR, (1)H NMR and mass spectral studies. The molecular structure of L was determined by single crystal X-ray diffraction studies. The electrochemical behaviour of the Ni(II) complexes indicate that the phen complexes appears at more positive potential as compared to those for bipy complexes, as a consequence of its strong π-acidic character...
January 18, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28101542/revisiting-secondary-interactions-in-neighboring-group-participation-exemplified-by-reactivity-changes-of-iminylium-intermediates
#6
Yingtang Ning, Tomoya Fukuda, Hirotaka Ikeda, Yuko Otani, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
Neighboring group participation is defined as the action of a substituent to stabilize a transition state or an intermediate by forming a bond or a partial bond with the reaction center. In addition to the primary interaction with the nearest neighboring group, secondary interactions involving another neighboring group(s) could also occur in principle. Here, we revisit this issue by examining the influence of secondary interactions on the stability and reactivity of the putative iminylium cation intermediates, formed by N-O bond cleavage of 1-tetralone oxime systems...
January 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28101178/endothelium-dependent-vasodilation-effects-of-panax-notoginseng-and-its-main-components-are-mediated-by-nitric-oxide-and-cyclooxygenase-pathways
#7
Yanyan Wang, Yu Ren, Leilei Xing, Xiangdong Dai, Sheng Liu, Bin Yu, Yi Wang
Panax notoginseng, a traditional Chinese herbal medicine, has been used for the treatment of cardiovascular diseases. The main bioactive components of this species are Panax notoginseng saponins (PNS). The present study aimed to investigate the effects of PNS and five of its main components (ginsenosides Rg1, Re, Rb1 and Rd, and notoginsenoside R1) on rat aorta rings pre-contracted with norepinephrine (NE) and to determine the underlying mechanism of action. Isolated aorta rings (with or without intact endothelium) from adult male Wistar rats were stimulated with NE to induce vasoconstriction, and subsequently treated with different concentrations of PNS and its five main components (Rg1, Re, Rb1, R1 and Rd) separately...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28098791/development-of-high-throughput-method-for-measurement-of-vascular-nitric-oxide-generation-in-microplate-reader
#8
Soad S Abd El-Hay, Christa L Colyer
BACKGROUND: Despite the importance of nitric oxide (NO) in vascular physiology and pathology, a high-throughput method for the quantification of its vascular generation is lacking. OBJECTIVE: By using the fluorescent probe 4-amino-5-methylamino-2',7'-difluorofluorescein (DAF-FM), we have optimized a simple method for the determination of the generation of endothelial nitric oxide in a microplate format. METHODS: A nitric oxide donor was used (3-morpholinosydnonimine hydrochloride, SIN-1)...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28094774/ab-initio-calculations-of-the-n-n-bond-dissociation-for-the-gas-phase-rdx-and-hmx
#9
Lin-Lin Liu, Pei-Jin Liu, Song-Qi Hu, Guo-Qiang He
NO2 fission is a vital factor for 1,3,5-Trinitroperhydro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) decomposition. In this study, the geometry of the gas-phase RDX and HMX molecules was optimized, and the bond order and the bond dissociation energy of the N-N bonds were examined. Moreover, the rate constants of the gas-phase RDX and HMX conformers, concerning the N-N bond dissociation, were evaluated using the microcanonical variational transition state theory (μVT). The calculation results have shown that HMX is more stable than RDX in terms of the N-N bond dissociation, and the conformers stability parameters were as follows: RDXaaa < RDXaae < HMX I < HMX II...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094504/the-2-fold-interpenetrating-bifunctional-cd-mofs-high-selective-adsorption-for-co2-and-sensitive-luminescent-sensing-of-nitro-aromatic-2-4-6-trinitrophenol
#10
Xu-Jia Hong, Qin Wei, Yuepeng Cai, Sheng-Run Zheng, Ying Yu, Yan-Zhong Fan, Xianyan Xu, Liping Si
A robust primitive diamond-type topology 3-D MOF of {[Cd4(hbhdpy)2(bdc)3(DMA)2]•(H2O)4}n (1, DMA = N,N-dimethylacetamide) was constructed from the planar secondary building units of the dinuclear cadmium clusters, Cd2(µ2-O)2, and two linear organic linkers of the new multidentate Schiff base of 4-(2-hydroxy-3-methoxy-benzyli-denehydrazino-carbonyl)-N-pyridin-4-yl-benzamide (Hhbhdpy) through the solvothermal reaction. 1 presents a 2-fold interpenetrating network along with confined narrow channels and rich acylamide groups as well as potential metal open sites for excellent selective CO2 uptake over CH4/N2 and high luminescent response for 2,4,6-trinitrophenol (TNP) in DMA solution under ambient conditions...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28094221/synthesis-biological-evaluation-and-molecular-docking-analysis-of-2-phenyl-benzofuran-3-carboxamide-derivatives-as-potential-inhibitors-of-staphylococcus-aureus-sortase-a
#11
Wan He, Yong Zhang, Jian Bao, Xinxian Deng, Jennifer Batara, Shawn Casey, Qiuyuan Guo, Faqin Jiang, Lei Fu
In Gram-positive bacteria, Sortase A (Srt A) is a critical cysteine transpeptidase that is responsible for recognizing and assembling surface virulence proteins through the recognition of a LPXTG (leucine, proline, X, threonine, and glycine, where X is any amino acid) signal. Mutants lacking genes for Srt A attenuate infections without affecting microbial viability. Here a series of 2-phenyl-benzofuran-3-carboxamide derivatives were synthesized and identified as potent Srt A inhibitors. Activity assays revealed that multiple compounds exhibited excellent inhibitory activity against Srt A compared with known Sortase A inhibitor pHMB (IC50=130μM)...
December 25, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28092771/plant-peroxisomes-a-nitro-oxidative-cocktail
#12
REVIEW
Francisco J Corpas, Juan B Barroso, José M Palma, Marta Rodriguez-Ruiz
Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability. In addition to the significant role played by plant peroxisomes in the metabolism of reactive oxygen species (ROS), data gathered over the last two decades show that these organelles are an endogenous source of nitric oxide (NO) and related molecules called reactive nitrogen species (RNS). Molecules such as NO and H2O2 act as retrograde signals among the different cellular compartments, thus facilitating integral cellular adaptation to physiological and environmental changes...
January 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28092695/absorption-distribution-and-excretion-of-the-anti-tuberculosis-drug-delamanid-in-rats-extensive-tissue-distribution-suggests-potential-therapeutic-value-for-extrapulmonary-tuberculosis
#13
Masakazu Shibata, Yoshihiko Shimokawa, Katsunori Sasahara, Noriaki Yoda, Hiroyuki Sasabe, Mitsunari Suzuki, Ken Umehara
Delamanid (OPC-67683, Deltyba(TM) , nitro-dihydro-imidazooxazoles derivative) is approved for the treatment of adult pulmonary multidrug-resistant tuberculosis. The absorption, distribution, and excretion of delamanid-derived radioactivity were investigated after a single oral administration of (14) C-delamanid at 3 mg/kg to rats. In both male and female rats, radioactivity in blood and all tissues reached peak levels by 8 or 24 hours postdose, and thereafter decreased slowly. Radioactivity levels were 3- to 5-fold higher in lung tissue at time to maximum concentration compared with plasma...
January 16, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28091881/identifying-metabolites-of-meclonazepam-by-high-resolution-mass-spectrometry-using-human-liver-microsomes-hepatocytes-a-mouse-model-and-authentic-urine-samples
#14
Svante Vikingsson, Ariane Wohlfarth, Mikael Andersson, Henrik Gréen, Markus Roman, Martin Josefsson, Fredrik C Kugelberg, Robert Kronstrand
Meclonazepam is a benzodiazepine patented in 1977 to treat parasitic worms, which recently appeared as a designer benzodiazepine and drug of abuse. The aim of this study was to identify metabolites suitable as biomarkers of drug intake in urine using high-resolution mass spectrometry, authentic urine samples, and different model systems including human liver microsomes, cryopreserved hepatocytes, and a mice model. The main metabolites of meclonazepam found in human urine were amino-meclonazepam and acetamido-meclonazepam; also, minor peaks for meclonazepam were observed in three of four urine samples...
January 13, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28091542/on-line-ammonia-sensor-and-invisible-security-ink-by-fluorescent-zwitterionic-spirocyclic-meisenheimer-complex
#15
Tanmay Das, Apurba Pramanik, Debasish Haldar
Ammonia is not only a highly important gas for civilization but also contribute significantly for climate change and human health hazard. Highly sensitive ammonia sensor has been developed from a fluorescent zwitterionic spirocyclic Meisenheimer complex. Moreover, formation of this Meisenheimer complex can also be utilized for selective as well as naked eye instant detection of nitro aromatic explosive picric acid. The presence of a quaternary nitrogen atom directly attached to the spiro carbon is the unique feature of this Meisenheimer complex...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087254/anti-diabetic-drug-metformin-dilates-retinal-blood-vessels-through-activation-of-amp-activated-protein-kinase-in-rats
#16
Asami Mori, Eriko Ishikawa, Tomoyo Amano, Kenji Sakamoto, Tsutomu Nakahara
The aim of this study was to examine whether metformin, a biguanide anti-hyperglycemic drug, dilates retinal blood vessels in rats. Ocular fundus images were captured with an original high-resolution digital fundus camera in vivo and diameters of retinal blood vessels were measured. Both systemic blood pressure and heart rate were continuously recorded. Metformin (0.01-0.3mg/kg/min) increased diameters of retinal blood vessels in a dose-dependent manner. This retinal vasodilator effect of metformin was abolished by compound C, an inhibitor of AMP-activated protein kinase (AMPK), and N(G)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide (NO) synthase...
January 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28069306/nitrated-polycyclic-aromatic-hydrocarbons-nitro-pahs-in-the-environment-a-review
#17
REVIEW
Benjamin A Musa Bandowe, Hannah Meusel
Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) are derivatives of PAHs with at least one nitro-functional group (-NO2) on the aromatic ring. The toxic effects of several nitro-PAHs are more pronounced than those of PAHs. Some nitro-PAHs are classified as possible or probable human carcinogens by the International Agency for Research on Cancer. Nitro-PAHs are released into the environment from combustion of carbonaceous materials (e.g. fossil fuels, biomass, waste) and post-emission transformation of PAHs...
January 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28067105/antimicrobial-effects-of-mastic-extract-against-oral-and-periodontal-pathogens
#18
Stefka Koychev, Henrik Dommisch, Hong Chen, Nicole Pischon
BACKGROUND: Various antimicrobial agents are widely used in the therapy of oral inflammatory diseases. However, their side effects and the appearance of drug resistance justify research on natural antimicrobial agents to target oral pathogens that are safe for the host. In the present study, antimicrobial properties of mastic extract on commensal and pathogenic oral bacteria, as well as its possible cytotoxic effect toward cells of epithelial and mesenchymal origin, were evaluated in comparison to the common antimicrobial agents hydrogen peroxide (H2O2) and chlorhexidine digluconate (CHX)...
January 8, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28065544/solar-radiation-as-a-swift-pathway-for-pah-photodegradation-a-field-study
#19
Montse Marquès, Montse Mari, Jordi Sierra, Martí Nadal, José L Domingo
The photodegradation of polycyclic aromatic hydrocarbons (PAHs) may be an important degradation pathway of PAHs in regions with a high solar radiation. The present investigation was aimed at studying the photodegradation of PAHs after their deposition on surface soils with different textures. Photodegradation by-products were also identified and semi-quantified, as well as correlated with the decrease of parent compounds. The experiment was performed by deploying soil samples spiked with a mixture of the 16 US EPA priority PAHs in a methacrylate box, exposed to solar radiation for 7days, meaning a solar energy of 102...
January 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28063941/nitro-oleic-acid-regulates-growth-factor-induced-differentiation-of-bone-marrow-derived-macrophages
#20
Hana Verescakova, Gabriela Ambrozova, Lukas Kubala, Tomas Perecko, Adolf Koudelka, Ondrej Vasicek, Tanja K Rudolph, Anna Klinke, Steven R Woodcock, Bruce A Freeman, Michaela Pekarova
Many diseases accompanied by chronic inflammation are connected with dysregulated activation of macrophage subpopulations. Recently, we reported that nitro-fatty acids (NO2-FAs), products of metabolic and inflammatory reactions of nitric oxide and nitrite, modulate macrophage and other immune cell functions. Bone marrow cell suspensions were isolated from mice and supplemented with macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with NO2-OA for different times...
January 4, 2017: Free Radical Biology & Medicine
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