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https://www.readbyqxmd.com/read/28433656/impaired-endothelium-derived-hyperpolarization-type-relaxation-in-superior-mesenteric-arteries-isolated-from-female-otsuka-long-evans-tokushima-fatty-rats
#1
Takayuki Matsumoto, Shota Kobayashi, Makoto Ando, Shun Watanabe, Maika Iguchi, Kumiko Taguchi, Tsuneo Kobayashi
Endothelium-derived hyperpolarization (EDH) is an important signaling mechanism of endothelium-dependent vasorelaxation, and little attention has been paid to the EDH-type responses in female metabolic syndrome such as that observed with type-2 diabetes. We previously reported that EDH-type relaxation was impaired in superior mesenteric arteries from male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of type-2 diabetes, however, the response was unclear in female OLETF rat. Thus, the aim of this study was to examine if EDH-type relaxation was altered in superior mesenteric arteries isolated from female OLETF rats compared to age-matched, control female Long-Evans Tokushima Otsuka (LETO) rats at age 50-59 weeks...
April 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28433551/in-vitro-investigation-of-metabolic-profiling-of-newly-developed-topoisomerase-inhibitors-ethyl-fluorescein-hydrazones-etflhs-in-rlms-by-lc-ms-ms
#2
Adnan A Kadi, Nasser S Al-Shakliah, Wencui Yin, A F M Motiur Rahman
Metabolic profiling of newly reported five topoisomerase inhibitors namely ethyl fluorescein hydrazones (EtFLHs) were studied in rat liver microsomes (RLMs) and the data were acquired in a liquid chromatography (LC) ion trap mass spectrometry. Hydroxyl group containing EtFLHs derivatives (1-3) were bio-transformed into hydrolyzed, mono-hydroxylated and hydrolyzed together with mono-hydroxylated metabolites. On the other hand, nitro and methoxy groups containing EtFLHs derivatives (4-5) were bio-transformed into hydrolyzed, hydrolyzed together with mono-hydroxylated and azo-reductive metabolites in the presence of NADPH...
April 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28431352/degradation-of-sulfamethoxazole-by-uv-uv-h2o2-and-uv-persulfate-pds-formation-of-oxidation-products-and-effect-of-bicarbonate
#3
Yi Yang, Xinglin Lu, Jin Jiang, Jun Ma, Guanqi Liu, Ying Cao, Weili Liu, Juan Li, Suyan Pang, Xiujuan Kong, Congwei Luo
The frequent detection of sulfamethoxazole (SMX) in wastewater and surface waters gives rise of concerns about their ecotoxicological effects and potential risks to induce antibacterial resistant genes. UV/hydrogen peroxide (UV/H2O2) and UV/persulfate (UV/PDS) advanced oxidation processes have been demonstrated to be effective for the elimination of SMX, but there is still a need for a deeper understanding of product formations. In this study, we identified and compared the transformation products of SMX in UV, UV/H2O2 and UV/PDS processes...
March 28, 2017: Water Research
https://www.readbyqxmd.com/read/28431342/discovery-of-tetrahydrocarbazoles-as-dual-perk-and-prb-inhibitors
#4
Mahesh R Kulkarni, Madhav S Mane, Usha Ghosh, Rajiv Sharma, Nitin P Lad, Ankita Srivastava, Asha Kulkarni-Almeida, Prashant S Kharkar, Vijay M Khedkar, Shivaji S Pandit
The extracellular signal-regulated kinase (ERK) is one of the most important molecular targets for cancer that controls diverse cellular processes such as proliferation, survival, differentiation and motility. Similarly, the Rb (retinoblastoma protein) is a tumor suppressor protein and its function is to prevent excessive cell growth by inhibiting cell cycle progression. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. Herein, we discovered a new series of tetrahydrocarbazoles as dual inhibitors of pERK and pRb phosphorylation...
March 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28431318/assessing-seasonal-variation-of-synthetic-musks-in-beach-sands-from-oporto-coastal-area-a-case-study
#5
Vera Homem, Inês Magalhães, Arminda Alves, Lúcia Santos
Synthetic musk compounds are widely used in the formulation of several cosmetics, personal care and household products. Due to their massive and widespread use, together with some health concerns, they are considered emerging pollutants and have been detected in different environmental compartments. This study focused on the evaluation of the concentration of synthetic musks (five nitro, five polycyclic and one macrocyclic musks) in beach sands, from Oporto coastal area (Portugal), contributing to the enhancement of the knowledge of levels, trends and behaviour of these compounds in this particular matrix...
April 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28429935/saponins-ginsenosides-from-the-leaves-of-panax-quinquefolius-ameliorated-acetaminophen-induced-hepatotoxicity-in-mice
#6
Xingyue Xu, Junnan Hu, Zhi Liu, Rui Zhang, Yufang He, Wei Hou, Zhiqing Wang, Ge Yang, Wei Li
Acetaminophen (APAP) overdose is the most frequent inducement of drug-induced acute liver injury (ALI). The purpose of this study was to investigate the protective effect of saponins (ginsenosides) from the leaves of Panax quinquefolius (PQS) against APAP-induced hepatotoxicity and the involved mechanism were investigated. Mice were pretreated with PQS (150 and 300 mg/kg) by oral gavage for seven days before being treated with 250 mg/kg APAP. Sever liver injury was exerted at 24 h post-APAP and hepatotoxicity was assessed...
April 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28428697/geraniol-inhibits-endometrial-carcinoma-via-downregulating-oncogenes-and-upregulating-tumour-suppressor-genes
#7
Sakkaravarthy Shanmugapriya, Perumal Subramanian, Sivamani Kanimozhi
Endometrial carcinoma is the fourth most abundant cancer worldwide in women. Female Wistar rats were segregated into five groups: group I-control, group II-MNNG (N-methyl-N'-nitro-N-nitrosoguanidine-150 mg/kg) administered through intravaginal detention of cotton absorbent, group III-geraniol (GOH) only, group IV-GOH-pretreated (7 days before the start of MNNG administration); and group V-Co-administration of geraniol with MNNG. In this study, reverse transcriptase- PCR of K-ras, MAPK, PI3K, Wnt/β-catenin genes, TGF-β and expressions of PCNA, PTEN, progesterone receptor and E-cadherin by Western blotting were performed from endometrial cancer tissue and control tissues...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428128/novel-combination-of-zero-valent-cu-and-ag-nanoparticles-cellulose-acetate-nanocomposite-for-the-reduction-of-4-nitro-phenol
#8
Farman Ullah Khan, Asimullah, Sher Bahadar Khan, Tahseen Kamal, Abdullah M Asiri, Ihsan Ullah Khan, Kalsoom Akhtar
A very simple and low-cost procedure has been adopted to synthesize efficient copper (Cu), silver (Ag) and copper-silver (Cu-Ag) mixed nanoparticles on the surface of pure cellulose acetate (CA) and cellulose acetate-copper oxide nanocomposite (CA-CuO). All nanoparticles loaded onto CA and CA-CuO presented excellent catalytic ability, but Cu-Ag nanoparticles loaded onto CA-CuO (Cu-Ag/CA-CuO) exhibited outstanding catalytic efficiency to convert 4-nitrophenol (4-NP) into 4-aminophenol (4-AP) in the presence of NaBH4...
April 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28426207/fe3o4-feni-embedded-nanostructure-and-its-kinetic-law-for-selective-catalytic-reduction-of-p-nitrophenyl-compounds
#9
Dandan Wu, Yanqiao Zhang, Ming Wen, Hao Fang, Qingsheng Wu
To meet the requirement of high catalytic efficiency toward the reduction of p-nitrophenyl compounds, we designed a new one-dimensional Fe3O4/FeNi embedded-nanostructured catalyst synthesized by a one-pot controlling-growth-reduction process in a solvothermal system, in which Fe3O4 phase was implanted in the base of FeNi alloy. In the Fe3O4/FeNi catalyst system, the Fe3O4 embedded phase attracts the nitro group of p-nitrophenyl compounds by its high-density electrons, which can efficiently promote the activity of amorphous FeNi active centers for selective catalysis toward the reduction of a range of p-nitrophenyl compounds...
April 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28423921/phytochemical-investigations-and-evaluation-of-antimutagenic-activity-of-the-alcoholic-extract-of-glycosmis-pentaphylla-and-tabernaemontana-coronaria-by-ames-test
#10
Ashish Kumar, Nilanjana Banerjee, Venugopal Singamaneni, Sudheer K Dokuparthi, Tulika Chakrabarti, Sibabrata Mukhopadhyay
Chemical investigation of root bark of Glycosmis pentaphylla and stem bark of Tabernaemontana coronaria led to the isolation of three carbazole alkaloids glycozoline, glycozolidine and methyl carbazole 3-carboxylate, two furoquinoline alkaloids skimmianine and dictamine, an acridone alkaloid arborinine, three monomeric indole alkaloids coronaridine, 10-methoxy coronaridine and tabernaemontanine, and two dimeric indole alkaloids voacamine and tabernaelegantine B. Their structures were established by detailed spectral analysis...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28422436/tandem-transformation-of-nitro-compounds-to-n-methylated-amines-greener-strategy-for-the-utilization-of-methanol-as-a-methylating-agent
#11
Bhaskar Paul, Sujan Shee, Kaushik Chakrabarti, Sabuj Kundu
A simple air and moisture stable, highly efficient NNN ruthenium catalyst is reported for the first time to catalyse the tandem transformation of various aromatic and aliphatic nitro compounds to the corresponding N-methylated amines up to 98% yields using methanol as a green and sustainable methylating agent. Gram scale reactions using challenging nitro substrates demonstrated the practical application aspects of this catalytic system. Importantly, N-methylamine group was smoothly introduced to various complex molecular setting without using any expensive Pd/phosphine/amine based cross coupling reaction...
April 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28418251/enantio-and-diastereoselective-nitro-mannich-reaction-of-%C3%AE-aryl-nitromethanes-with-amidosulfones-catalyzed-by-phase-transfer-catalysts
#12
Ning Lu, Ruxu Li, Zhonglin Wei, Jungang Cao, Dapeng Liang, Yingjie Lin, Haifeng Duan
A high-yield, highly diastereo- and enantioselective nitro-Mannich reaction of α-aryl nitromethanes with amidosulfones cat-alyzed by a novel chiral phase-transfer catalyst, bearing multiple H-bonding donors, derived from quinine was developed. A variety of α-aryl nitromethanes and amidosulfones were investigated; and the corresponding products were obtained in ex-cellent yields with excellent diastereo- and enantioselectivities (up to 99% yield, >99:1 dr and >99% ee). As a demonstration of synthetic utility, the resulting β-nitroamines could be converted to corresponding meso-symmetric and optically pure un-symmetric anti-1,2-diarylethylenediamines...
April 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28418184/b-c6-f5-3-catalyzed-cascade-reduction-of-pyridines
#13
Zhi-Yun Liu, Zhi-Hui Wen, Xiao-Chen Wang
B(C6 F5 )3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28414944/direct-and-indirect-electrochemical-reduction-prior-to-a-biological-treatment-for-dimetridazole-removal
#14
Melika Zaghdoudi, Florence Fourcade, Isabelle Soutrel, Didier Floner, Abdeltif Amrane, Hager Maghraoui-Meherzi, Florence Geneste
Two different electrochemical reduction processes for the removal of dimetridazole, a nitroimidazole-based antibiotic, were examined in this work. A direct electrochemical reduction was first carried out in a home-made flow cell in acidic medium at potentials chosen to minimize the formation of amino derivatives and then the formation of azo dimer. Analysis of the electrolyzed solution showed a total degradation of dimetridazole and the BOD5/COD ratio increased from 0.13 to 0.24. An indirect electrochemical reduction in the presence of titanocene dichloride ((C5H5)2TiCl2), which is used to reduce selectively nitro compounds, was then investigated to favour the formation of amino compounds over hydroxylamines and then to prevent the formation of azo and azoxy dimers...
April 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28414231/organic-phosphorescence-nanowire-lasers
#15
Zhenyi Yu, Yishi Wu, Lu Xiao, Jianwei Chen, Qing Liao, Jiannian Yao, Hongbing Fu
Organic solid-state lasers (OSSLs) based on singlet fluorescence have merited intensive study as an important class of light sources. Although the use of triplet phosphors has led to 100% internal quantum efficiency in organic light emitting diodes (OLEDs), stumbling blocks in triplet lasing include generally forbidden intersystem crossing (ISC) and low quantum yield of phosphorescence (ΦP). Here, we reported the first triplet-phosphorescence OSSL from nanowire microcavity of a sulfide-substituted difluoroboron compound...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28412628/4-nitroso-sulfamethoxazole-generation-in-soil-under-denitrifying-conditions-field-observations-versus-laboratory-results
#16
Monica Brienza, Céline Duwig, Sandra Pérez, Serge Chiron
The formation of 4-nitroso-sulfamethoxazole and 4-nitro-SMX, two transformation products (TPs) of sulfamethoxazole (SMX) was investigated under batch soil slurry experiments and in a field study. Due to their low occurrence levels (ng/L) in environmental waters, a suitable analytical method based on liquid chromatography - high resolution - mass spectrometry was developed. Consequently, field observations revealed, for the first time, the occurrence of 4-nitroso-SMX in groundwater at concentrations as high as 18ng/L...
April 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28411554/emodin-suppresses-the-nasopharyngeal-carcinoma-cells-by-targeting-the-chloride-channels
#17
Lianshun Ma, Yaping Yang, Zizhang Yin, Mei Liu, Liwei Wang, Lixin Chen, Linyan Zhu, Haifeng Yang
Emodin is a natural anthraquinone derivative isolated from the Rheum palmatum. Recent studies demonstrated that emodin has anti-cancer activity in different kinds of human cancer cell lines. However, the underlying mechanism has not been very well studied. Our previous studies showed chloride channels is an important target of anti-cancer drugs. Therefore, the purpose of this research was aimed to explore the role of chloride channels involving in the anti-cancer activity of emodin. The proliferation, cell cycle arrest and apoptosis of poorly differentiated human nasopharyngeal carcinoma cells (CNE-2Z) and normal nasopharyngeal epithelial cells (NP69-SV40T) were detected by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT)and flow cytometry...
April 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28411035/altered-ion-transport-in-normal-human-bronchial-epithelial-cells-following-exposure-to-chemically-distinct-metal-welding-fume-particles
#18
Jeffrey S Fedan, Janet A Thompson, Terence G Meighan, Patti C Zeidler-Erdely, James M Antonini
Welding fume inhalation causes pulmonary toxicity, including susceptibility to infection. We hypothesized that airway epithelial ion transport is a target of fume toxicity, and investigated the effects of fume particulates from manual metal arc-stainless steel (MMA-SS) and gas metal arc-mild steel (GMA-MS) on ion transport in normal human bronchial epithelium (NHBE) cultured in air-interface. MMA-SS particles, more soluble than GMA-MS particles, contain Cr, Ni, Fe and Mn; GMA-MS particles contain Fe and Mn...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28408902/the-naturally-occurring-host-defense-peptide-ll-37-and-its-truncated-mimetics-ke-18-and-kr-12-have-selected-biocidal-and-antibiofilm-activities-against-candida-albicans-staphylococcus-aureus-and-escherichia-coli-in-vitro
#19
Yu Luo, Denise T F McLean, Gerard J Linden, Danny F McAuley, Ronan McMullan, Fionnuala T Lundy
Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. It is also plausible that truncated versions will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. The host defense peptide, LL-37, and two truncated mimetics, KE-18 and KR-12, were tested for their inhibitory effects and antibiofilm properties against Candida albicans, Staphylococcus aureus, and Escherichia coli, microorganisms commonly implicated in biofilm-related infections such as ventilator-associated pneumonia (VAP)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28407456/3-nitro-2-pyridinesulfenates-as-efficient-solution-and-solid-phase-disulfide-bond-forming-agents
#20
Akihiro Taguchi, Kiyotaka Kobayashi, Akira Kotani, Kyohei Muguruma, Misaki Kobayashi, Kentarou Fukumoto, Kentaro Takayama, Hideki Hakamata, Yoshio Hayashi
In this paper, we describe a new disulfide-forming agent based on the finding that alkoxy 3-nitro-2-pyridinesulfenates (Npys-OR) can oxidize thiol groups. Methyl 3-nitro-2-pyridinesulfenate (Npys-OMe), which is easily prepared from 3-nitro-2-pyridinesulfenyl chloride in a one-step reaction and has a reduction peak potential (Epc) of -0.543 V vs. Ag/AgCl, produces the cyclic nonapeptide oxytocin from its linear form in a good yield (92%) with minimal oligomer formation. Npys-OMe in the solid-phase also demonstrated excellent results in oxytocin synthesis...
April 13, 2017: Chemistry: a European Journal
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