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https://www.readbyqxmd.com/read/28732338/toxic-organic-substances-and-marker-compounds-in-size-segregated-urban-particulate-matter-implications-for-involvement-in-the-in%C3%A2-vitro-bioactivity-of-the-extractable-organic-matter
#1
Athanasios Besis, Alexandra Tsolakidou, Dimitra Balla, Constantini Samara, Dimitra Voutsa, Anastasia Pantazaki, Theodora Choli-Papadopoulou, Theodore S Lialiaris
Toxic organic substances and polar organic marker compounds, i.e. polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs) and their nitro-derivatives (N-PAHs), as well as dicarboxylic acids (DCAs) and sugars/sugar anhydrites (S/SAs) were analyzed in size-segregated PM samples (<0.49, 0.49-0.97, 0.97-3 and >3 μm) collected at two urban sites (urban traffic and urban background) during the cold and the warm season...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28731341/a-2d-coordination-network-that-detects-nitro-explosives-in-water-catalyzes-baylis-hillman-reactions-and-undergoes-unusual-2d%C3%A2-3d-single-crystal-to-single-crystal-transformation
#2
Vivekanand Sharma, Dinesh De, Sanchari Pal, Prithwidip Saha, Parimal K Bharadwaj
The solvothermal reaction of Zn(NO3)2·6H2O and a linear dicarboxylate ligand H2L, in the presence of urotropine in N,N'-dimethylformamide (DMF), gives rise to a new porous two-dimensional (2D) coordination network, {[Zn3(L)3(urotropine)2]·2DMF·3H2O}n (1), with hxl topology. Interestingly, framework 1 exhibits excellent emission properties owing to the presence of naphthalene moiety in the linker H2L, that can be efficiently suppressed by subtle quantity of nitro explosives in aqueous medium. Furthermore, presence of urotropine molecules bound to the metal centers, 1 is found to be an excellent heterogeneous catalyst meant for atom-economical C-C bond-forming Baylis-Hillman reactions...
July 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28731132/mir-374-mediates-the-malignant-transformation-of-gastric-cancer-associated-mesenchymal-stem-cells-in-an-experimental-rat-model
#3
Runbi Ji, Xu Zhang, Hui Qian, Hongbing Gu, Zixun Sun, Fei Mao, Yongmin Yan, Jingyan Chen, Zhaofeng Liang, Wenrong Xu
Mesenchymal stem cells (MSCs) are a critical component of the tumor microenvironment. Upon distinct pathological stimulus, MSCs show phenotypic and functional changes. Gastric cancer is one of the leading causes of cancer‑related deaths worldwide. The roles and mechanisms of MSCs in gastric cancer have not been well characterized. In the present study, we investigated the roles of MSCs in the malignant transformation from gastritis to gastric cancer using an N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer model...
July 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28728109/zero-valent-aluminum-for-reductive-removal-of-aqueous-pollutants-over-a-wide-ph-range-performance-and-mechanism-especially-at-near-neutral-ph
#4
Shiying Yang, Di Zheng, Tengfei Ren, Yixuan Zhang, Jia Xin
Zero-valent aluminum (ZVAl) draws much attention due to its strong reducibility. However, under neutral pH conditions, the reduction ability of ZVAl for pollutant removal has still been suspected because of the formed compact surface film of Al-(hydr)oxide. In this study, unmodified ZVAl was employed to reductively remove aqueous pollutants over a wide pH range, and its performance and mechanism, especially at near-neutral pH, were systematically studied for the first time. Results demonstrated that ZVAl had a wide range of pH applicability from 2 to 12, even in neutral environment...
July 6, 2017: Water Research
https://www.readbyqxmd.com/read/28727921/effect-of-lysophosphatidylglycerol-on-intracellular-free-ca2-concentration-in-a10-vascular-smooth-muscle-cells
#5
Ying Zhang, Jing-Dian Zhang, Ming-Qin Zhu, Ming Zhang, Yan-Jun Xu, Li Cui, Naranjan S Dhalla
Although plasma levels of lysophosphatidylglycerol (LPG) are increased in hypertension, its role in the pathogenesis of vascular defects is not clear. In view of the importance of Ca2+-overload in causing vascular smooth muscle (VSM) dysfunction, the action of LPG on [Ca2+]i in cultured A10 VSM cell line was examined by using Fura 2-AM acetoxymethyl ester technique. LPG was found to induce a concentration-dependent increase in [Ca2+]i in VSM cells. This change was dependent both on the extracellular and intracellular Ca2+ sources as it was reduced by 30% by EGTA, an extracellular Ca2+ chelator, and 70% by tharpsigargin, a sarcoplasmic reticulum (SR) Ca2+-pump inhibitor...
July 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28727904/electrophilic-amination-with-nitroarenes
#6
Marian Rauser, Christoph Ascheberg, Meike Niggemann
An exceptionally general electrophilic amination, which directly transforms commercially available nitroarenes with zinc organyls to alkylated aromatic aminoboranes was developed. The reaction starts with a two-step partial reduction of the nitro group to a nitrenoid, which is used in-situ as the electrophilic amination reagent. To facilitate isolation, the resulting air and moisture sensitive aminoboranes were reacted with a range of electrophiles. The protocol not only represents a direct transformation of nitro compounds into an electrophilic amination reagent but also provides an elegant alternative to dehydrocoupling methods for the generation of aminoboranes...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28726672/the-influence-of-surface-potential-on-the-optical-switching-of-spiropyran-self-assembled-monolayers
#7
Tobias Garling, Yujin Tong, Tamim Darwish, Martin Wolf, R Kramer Campen
Surfaces whose macroscopic properties can be switched by light are potentially useful in a wide variety of applications. One such promising application is electrochemical sensors that can be gated by optically switching the electrode <i>on</i> or <i>off</i>. One way to make such a switchable electrode is by depositing a self-assembled monolayer of bistable, optically switchable molecules onto an electrode surface. Quantitative application of any such sensor requires understanding how changes in interfacial field affect the composition of photostationary states, <i>i...
July 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28726567/possible-mechanisms-involved-in-the-anti-nociceptive-effects-of-hydro-ethanolic-leaf-extract-of-ziziphus-abyssinica
#8
Eric Boakye-Gyasi, Isaac Tabiri Henneh, Wonder Kofi Mensah Abotsi, Elvis Ofori Ameyaw, Eric Woode
CONTEXT: Various parts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) have been used in Ghanaian and African traditional medicine as an analgesic. However, there are little scientific data to support the anti-nociceptive effects of the hydro-ethanolic leaf extract of Ziziphus abyssinica (EthE) as well as the possible mechanisms involved in its anti-nociceptive effects. PURPOSE: To predict possible nociceptive pathways involved in the anti-nociceptive effects of EthE...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28726518/differential-responses-of-mesenteric-arterial-bed-to-vasoactive-substances-in-l-name-induced-preeclampsia-role-of-oxidative-stress-and-endothelial-dysfunction
#9
Taline A S Amaral, Dayane T Ognibene, Lenize C R M Carvalho, Ana Paula M Rocha, Cristiane A Costa, Roberto S Moura, Angela C Resende
To investigate the systemic and placental oxidant status as well as vascular function in experimental preeclampsia (PE) induced by nitro-L-arginine methyl ester (L-NAME). Fetal parameters and maternal blood pressure, proteinuria, mesenteric arterial bed (MAB) reactivity, and systemic and placental oxidative stress were compared between four groups: pregnant rats receiving L-NAME (60 mg/kg/day, orally) (P + L-NAME) or vehicle (P) from days 13 to 20 of pregnancy and nonpregnant rats receiving L-NAME (NP + L-NAME) or vehicle (NP) during 7 days...
July 20, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28726345/enantioselective-construction-of-trifluoromethoxylated-stereogenic-centers-by-nickel-catalyzed-asymmetric-suzuki-miyaura-coupling-of-secondary-benzyl-bromides
#10
Weichen Huang, Xiaolong Wan, Qilong Shen
A method for the construction of trifluoromethoxy-containing stereogenic centers with high enantiometric excess via nickel-catalyzed Suzuki-Miyaura coupling of easily available -bromobenzyl trifluoromethylethers 1a-g with a variety of aryl pinacol boronates was described. The reaction conditions were mild and a variety of common functional groups such as fluoride, chloride, bromide, ester, enolizable ketone, nitro, cyano, amino and vinyl group were well tolerated. Furthermore, the reaction can be easily scaled up to gram quantities without erosion of the enantioselectivity...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28724263/mutagenesis-and-characterization-of-a-bacillus-amyloliquefaciens-strain-for-cinnamomum-camphora-seed-kernel-oil-extraction-by-aqueous-enzymatic-method
#11
Cheng Zeng, Rongbin Zhao, Maomao Ma, Zheling Zeng, Deming Gong
The purpose of the present study was to increase the proteinase activity of the strain NCU116 by combining ultraviolet irradiation and N-methyl-N'-nitro-N-nitroso guanidine treatment, in order to enhance the efficiency of Cinnamomum camphora seed kernel oil (CCSKO) extraction by aqueous enzymatic method (AEM). The mutated strain, designated as NCU116-1, was screened out by the ratio of hydrolytic zone diameter to colony diameter on skim milk plate. The proteinase activity (9116.1 U/ml) of NCU116-1 was increased by 31...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28723153/understanding-the-reactivity-of-co3-%C3%A2-and-no2-%C3%A2-radicals-towards-s-containing-and-aromatic-amino-acids
#12
Sharmistha Karmakar, Ayan Datta
The reactivity of CO3-(.) and NO2(.) radicals towards six amino acid side chains namely, cysteine (Cys), methionine (Met), phenylalanine (Phe), tyrosine (Tyr), histidine (His) and tryptophan (Trp), has been explored using state-of-art density functional theory (DFT) and transition state theory (TST). Three reaction mechanisms, namely hydrogen atom abstraction (HAT), radical adduct formation (RAF) and single electron transfer (SET) have been considered for detailed study. While CO3-(.) radical is highly reactive towards majority of amino acids, the reactivity of NO2(...
July 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28722745/co-catalyzed-highly-selective-c-sp-3-h-nitration
#13
Yao Zhou, Zhonghe Tang, Qiuling Song
A Co-catalyzed highly chemo- and regio-selective nitration of C(sp(3))-H was developed. Diverse aliphatic nitro compounds were obtained in good yields, using t-BuONO as a nitrating reagent. Specific nitration of C(sp(3))-H instead of C(sp(2))-H was achieved via a radical process rather than concerted metalation-deprotonation.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28722259/l-ornithine-and-l-lysine-stimulate-gastrointestinal-motility-via-transient-receptor-potential-vanilloid-1
#14
Junya Nakato, Yee Yin Ho, Ryo Omae, Takafumi Mizushige, Kunitoshi Uchida, Makoto Tominaga, Minji Kim, Tsuyoshi Goto, Nobuyuki Takahashi, Teruo Kawada, Saori Akiduki, Ryuhei Kanamoto, Kousaku Ohinata
SCOPE: The gastrointestinal (GI) tract senses and responds to intraluminal nutrients and these interactions often affect GI functions. We found that, among basic amino acids, L-ornithine (Orn) and L-lysine (Lys) stimulated but L-arginine (Arg) suppressed GI motility after oral administration (24 mmol/kg) in mice (Orn and Lys, 14.3 and 26.4% promotion; Arg, 7.7% suppression). We investigated the mechanism of the action of Orn and Lys on GI motility. METHODS AND RESULTS: Orn-induced promotion of small intestinal transit was significantly inhibited (P<0...
July 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28722219/preparation-and-evaluation-of-tert-leucine-derivative-functionalized-polymeric-monoliths-for-micro-liquid-chromatography
#15
Meng Ruan, Qiqin Wang, Huihui Wu, Yuqiang Wang, Hai Han, Zhengjin Jiang
In the present study, a novel functional monomer N-[1-(α-naphthyl)ethylaminocarbonyl]-D-tert-leucine-[2-(methacryloyloxy)ethyl] amide (NA-D-tert-Leu-MA) was synthesized, and then employed to prepare polymeric monoliths (240 mm × 100 μm I.D.) functionalized with tert-leucine derivative through a single step thermo-initiated co-polymerization approach or a multi-step post-modification approach. The multi-step approach involves the post-modification of a thiol-containing monolith with NA-D-tert-Leu-MA via "thiol-ene" click reaction...
July 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28720004/antinociceptive-synergistic-interaction-between-achillea-millefolium-and-origanum-vulgare-l-extract-encapsulated-in-liposome-in-rat
#16
Farshad Hassanzadeh-Kiabi, Babak Negahdari
AIM: This study aims to evaluate the antinociceptive effect of combined Achillea millefolium and Origanum extract encapsulated in liposome. METHODS: The effect of Achillea millefolium and Origanum vulgare L. extract, and their liposome-incorporated form was assessed using 3% formalin test in rat. 12 male Wistar rats, 4 in each group, were used in this study, and increasing doses of Achillea millefolium (31.6, 100, 178, and 316 mg/kg) and Origanum vulgare L. extract (5...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28719801/biology-oriented-drug-synthesis-biods-of-2-2-methyl-5-nitro-1h-imidazol-1-yl-ethyl-aryl-ether-derivatives-in-vitro-%C3%AE-amylase-inhibitory-activity-and-in-silico-studies
#17
Muhammad Taha, Syahrul Imran, Nor Hadiani Ismail, Manikandan Selvaraj, Fazal Rahim, Sridevi Chigurupati, Hayat Ullah, Fahad Khan, Uzma Salar, Muhammad Tariq Javid, Shantini Vijayabalan, Khalid Zaman, Khalid Mohammed Khan
A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives (1-23) were synthesized and characterized by EI-MS and (1)H NMR, and screened for their α-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC50=0.38±0.82µM) and 23 (IC50=1.66±0.14µM), showed excellent activity whereas the remaining compounds, except 10 and 17, showed good to moderate inhibition in the range of IC50=1.77-2.98µM when compared with the standard acarbose (IC50=1.66±0.1µM). A plausible structure-activity relationship has also been presented...
July 11, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28717994/modeling-and-investigation-of-new-explosive-materials-based-on-n-3-5-dimethyl-2-4-6-trinitrophenyl-1h-1-2-4-triazol-3-amine
#18
Jelena Tamuliene, Jonas Sarlauskas, Svajone Bekesiene
This study presents an investigation of the effects of adding extra nitro group substituents to N-(3,5-dimethyl-2,4,6-trinitrophenyl)-1H-1,2,4-triazol-3-amine (HEM-II) on its thermal and chemical stability as well as its explosive performance. An analysis of the thermal stabilities of HEM-II and HEM-II-based molecules based on an investigation of the binding energy per atom for each molecule was performed. The values of the gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) as well as those of the chemical hardness and softness for HEM-II and the HEM-II-based molecules were studied to determine the chemical stabilities of these molecules...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28717360/ethanol-enhances-high-salinity-stress-tolerance-by-detoxifying-reactive-oxygen-species-in-arabidopsis-thaliana-and-rice
#19
Huong Mai Nguyen, Kaori Sako, Akihiro Matsui, Yuya Suzuki, Mohammad Golam Mostofa, Chien Van Ha, Maho Tanaka, Lam-Son Phan Tran, Yoshiki Habu, Motoaki Seki
High-salinity stress considerably affects plant growth and crop yield. Thus, developing techniques to enhance high-salinity stress tolerance in plants is important. In this study, we revealed that ethanol enhances high-salinity stress tolerance in Arabidopsis thaliana and rice. To elucidate the molecular mechanism underlying the ethanol-induced tolerance, we performed microarray analyses using A. thaliana seedlings. Our data indicated that the expression levels of 1,323 and 1,293 genes were upregulated by ethanol in the presence and absence of NaCl, respectively...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28715686/a-new-aggregation-induced-emission-fluorescent-probe-for-rapid-detection-of-nitroreductase-and-its-application-in-living-cells
#20
Gaoping Xu, Yonghe Tang, Yanyan Ma, An Xu, Weiying Lin
The biological activity of nitroreductase (NTR) is closely related to biological hypoxia status in organisms. The development of effective methods for monitoring the activity of NTR is of great significance for medical diagnosis and tumor research. Toward this goal, we have developed a new aggregation-induced emission (AIE) fluorescence NTR probe TPE-HY used the tetraphenylethene as the fluorophore, and used the nitro group as the NTR recognition site. The probe TPE-HY has many excellent properties, including rapid response, AIE characteristics, high sensitivity and selectivity, and low cytotoxicity...
July 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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