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https://www.readbyqxmd.com/read/27199454/comprehensive-database-of-human-e3-ubiquitin-ligases-application-to-aquaporin-2-regulation
#1
Barbara Medvar, Viswanathan Raghuram, Trairak Pisitkun, Abhijit Sarkar, Mark A Knepper
Aquaporin-2 (AQP2) is regulated in part via vasopressin-mediated changes in protein half-life that are in turn dependent on AQP2 ubiquitination. Here we addressed the question, "What E3 ubiquitin ligase is most likely to be responsible for AQP2 ubiquitination?" using large-scale data integration based on Bayes' rule. The first step was to bioinformatically identify all E3 ligase genes coded by the human genome. The 377 E3 ubiquitin ligases identified in the human genome, consisting predominant of HECT, RING, and U-box proteins, have been used to create a publically accessible and downloadable online database (https://hpcwebapps...
July 1, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27173213/amfr-gene-silencing-inhibits-the-differentiation-of-porcine-preadipocytes
#2
C Z Chen, Y N Zhu, M L Chai, L S Dai, Y Gao, H Jiang, L J Zhang, Y Ding, S Y Liu, Q Y Li, W F Lu, J B Zhang
Our study clarifies the role of the autocrine motility factor receptor (AMFR) gene in porcine preadipocyte differentiation. AMFR-siRNA was transfected into porcine preadipocytes and the preadipocytes were induced to differentiation. Subsequently, qRT-PCR was conducted to examine changes in mRNA expression of a series of genes in porcine preadipocytes, including AMFR, sterol-regulatory element-binding protein-1a (SREBP1a), SREBP2, insulin-induced gene 1 (Insig1), and Insig2. Expression changes in the mRNA of genes regulating adipocyte differentiation were also analyzed using qRT-PCR, including peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and Kruppel-like factor 2 (KLF2)...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26949185/bok-is-a-non-canonical-bcl-2-family-effector-of-apoptosis-regulated-by-er-associated-degradation
#3
Fabien Llambi, Yue-Ming Wang, Bernadette Victor, Mao Yang, Desiree M Schneider, Sébastien Gingras, Melissa J Parsons, Janet H Zheng, Scott A Brown, Stéphane Pelletier, Tudor Moldoveanu, Taosheng Chen, Douglas R Green
The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolutely required for this process. Here, we report that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP that can trigger apoptosis in the absence of both BAX and BAK. However, unlike the canonical effectors, BOK appears to be constitutively active and unresponsive to antagonistic effects of the antiapoptotic BCL-2 proteins...
April 7, 2016: Cell
https://www.readbyqxmd.com/read/26736052/tracking-the-conversion-of-nitrogen-during-pyrolysis-of-antibiotic-mycelial-fermentation-residues-using-xps-and-tg-ftir-ms-technology
#4
Xiangdong Zhu, Shijun Yang, Liang Wang, Yuchen Liu, Feng Qian, Wenqing Yao, Shicheng Zhang, Jianmin Chen
Antibiotic mycelial fermentation residues (AMFRs), which are emerging solid pollutants, have been recognized as hazardous waste in China since 2008. Nitrogen (N), which is an environmental sensitivity element, is largely retained in AMFR samples derived from fermentation substrates. Pyrolysis is a promising technology for the treatment of solid waste. However, the outcomes of N element during the pyrolysis of AMFRs are still unknown. In this study, the conversion of N element during the pyrolysis of AMFRs was tracked using XPS (X-ray photoelectron spectroscopy) and online TG-FTIR-MS (Thermogravimetry-Fourier transform infrared-Mass spectrometry) technology...
April 2016: Environmental Pollution
https://www.readbyqxmd.com/read/26459914/neuroleukin-autocrine-motility-factor-receptor-pathway-promotes-proliferation-of-articular-chondrocytes-through-activation-of-akt-and-smad2-3
#5
Kang Tian, Weiliang Zhong, Xifu Zheng, Jinrui Zhang, Pixu Liu, Weiguo Zhang, Han Liu
Cartilage defect is an intractable clinical problem. Therapeutic strategies for cartilage repair are far from optimal due to poor proliferation capacity of chondrocytes. Autologous chondrocyte implantation is a cell based therapy that uses in vitro amplified healthy chondrocytes from the patient. However, chondrocyte dedifferentiation during in vitro culture limits its application. Neuroleukin (NLK) is a multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR, also called gp78)...
October 13, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26187955/the-pathway-specific-regulator-clar-of-streptomyces-clavuligerus-has-a-global-effect-on-the-expression-of-genes-for-secondary-metabolism-and-differentiation
#6
Yolanda Martínez-Burgo, Rubén Álvarez-Álvarez, Antonio Rodríguez-García, Paloma Liras
Streptomyces clavuligerus claR::aph is a claR-defective mutant, but in addition to its claR defect it also carries fewer copies of the resident linear plasmids pSCL2 and pSCL4 (on the order of 4 × 10(5)-fold lower than the wild-type strain), as shown by qPCR. To determine the function of ClaR without potential interference due to plasmid copy number, a new strain, S. clavuligerus ΔclaR::aac, with claR deleted and carrying the wild-type level of plasmids, was constructed. Transcriptomic analyses were performed in S...
October 2015: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/26159197/a-co-module-regulated-by-therapeutic-drugs-in-a-molecular-subnetwork-of-alzheimer-s-disease-identified-on-the-basis-of-traditional-chinese-medicine-and-samp8-mice
#7
Xiao-Rui Cheng, Xiu-Liang Cui, Yue Zheng, Gui-Rong Zhang, Peng Li, Huang Huang, Yue-Ying Zhao, Xiao-Chen Bo, Sheng-Qi Wang, Wen-Xia Zhou, Yong-Xiang Zhang
There are currently no approved effective therapies for Alzheimer's disease (AD). AD is a classic, multifactorial, complex syndrome. Thus, a polypharmacological or multitargeted approach to AD might provide better therapeutic benefits than monotherapies. However, it remains elusive which biological processes and biomolecules involved in the pathophysiologic processes of AD would constitute good targets for multitargeted therapy. This study proposes that a co-module, consisting of biological processes, cellular pathways and nodes, in a molecular subnetwork perturbed by different therapeutic drugs may be the optimal therapeutic target for an AD multitarget-based intervention...
2015: Current Alzheimer Research
https://www.readbyqxmd.com/read/26136223/autocrine-motility-factor-receptor-promotes-the-proliferation-of-human-acute-monocytic-leukemia-thp-1-cells
#8
Yingchao Wang, Lina Ma, Chunmei Wang, Guangyao Sheng, Lei Feng, Chuyun Yin
The aberrant activation of autocrine motility factor receptor (AMFR) has been implicated in several types of human cancer. The present study aimed to elucidate the effect of AMFR on the regulation of proliferation in an acute monocytic leukemia cell line, THP‑1. THP‑1 cells were transfected with AMFR‑targeted small interfering (si)RNA and a plasmid encoding a truncated AMFR, AMFR‑C, (pcDNA3.1‑AMFR‑C). The mRNA and protein levels of AMFR and the downstream targets, rho‑associated, coiled‑coil containing protein kinase 2 (ROCK2), cyclin D1, and B‑cell lymphoma (Bcl)‑2, were measured using reverse transcription‑quantitatibe polymerase chain reaction and immunoblot analyses...
September 2015: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/25852009/prognostic-significance-of-autocrine-motility-factor-receptor-expression-by-colorectal-cancer-and-lymph-node-metastases
#9
Yasmin Halwani, Liliana D Kojic, Simon K Chan, Terry P Phang, Hamid Masoudi, Steven J M Jones, Ivan R Nabi, Sam M Wiseman
BACKGROUND: Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. The aim of this study was to evaluate expression and prognostic significance of AMFR in colorectal carcinoma. METHODS: AMFR expression was evaluated in 127 colon cancer specimens, 131 rectal cancer specimens, and 47 colonic and 25 rectal corresponding lymph node metastases. Clinicopathological correlates of prognostic significance were established by univariate and multivariate analysis...
May 2015: American Journal of Surgery
https://www.readbyqxmd.com/read/25689831/affinity-proteomics-discovers-decreased-levels-of-amfr-in-plasma-from-osteoporosis-patients
#10
Ulrika Qundos, Kimi Drobin, Cecilia Mattsson, Mun-Gwan Hong, Ronald Sjöberg, Björn Forsström, David Solomon, Mathias Uhlén, Peter Nilsson, Karl Michaëlsson, Jochen M Schwenk
PURPOSE: Affinity proteomic approaches by antibody bead arrays enable multiplexed analysis of proteins in body fluids. In the presented study, we investigated blood plasma within osteoporosis to discovery differential protein profiles and to propose novel biomarkers candidates for subsequent studies. EXPERIMENTAL DESIGN: Starting with 4608 antibodies and plasma samples from 22 women for an untargeted screening, a set of 72 proteins were suggested for further analysis...
June 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/25526307/the-e3-ubiquitin-ligase-amfr-and-insig1-bridge-the-activation-of-tbk1-kinase-by-modifying-the-adaptor-sting
#11
Qiang Wang, Xing Liu, Ye Cui, Yijun Tang, Wei Chen, Senlin Li, Huansha Yu, Youdong Pan, Chen Wang
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for host immune responses triggered by microbial DNAs. However, the regulatory mechanisms underlying STING-mediated signaling are not fully understood. We report here that, upon cytoplasmic DNA stimulation, the endoplasmic reticulum (ER) protein AMFR was recruited to and interacted with STING in an insulin-induced gene 1 (INSIG1)-dependent manner. AMFR and INSIG1, an E3 ubiquitin ligase complex, then catalyzed the K27-linked polyubiquitination of STING...
December 18, 2014: Immunity
https://www.readbyqxmd.com/read/25526298/adding-to-the-sting
#12
COMMENT
Hong-Bing Shu, Yan-Yi Wang
STING (also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination of STING (MITA) by the ER-associated E3 ligase AMFR is essential for STING (MITA)-mediated signaling and innate antiviral response.
December 18, 2014: Immunity
https://www.readbyqxmd.com/read/25478440/immunohistochemical-expression-of-type-iv-collagen-and-autocrine-motility-factor-receptor-in-odontogenic-tumours
#13
Harshaminder Kaur Grewal, Sneha Sethi
BACKGROUND: Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neoplastic lesions. Basement membranes are specialized extracellular matrices that serve as structural barriers as well as substrates for cellular interactions. The network of type IV collagen is thought to define the scaffold integrating other components such as laminins and perlecan into highly organized supramolecular architecture...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25385046/rer1-and-calnexin-regulate-endoplasmic-reticulum-retention-of-a-peripheral-myelin-protein-22-mutant-that-causes-type-1a-charcot-marie-tooth-disease
#14
Taichi Hara, Yukiko Hashimoto, Tomoko Akuzawa, Rika Hirai, Hisae Kobayashi, Ken Sato
Peripheral myelin protein 22 (PMP22) resides in the plasma membrane and is required for myelin formation in the peripheral nervous system. Many PMP22 mutants accumulate in excess in the endoplasmic reticulum (ER) and lead to the inherited neuropathies of Charcot-Marie-Tooth (CMT) disease. However, the mechanism through which PMP22 mutants accumulate in the ER is unknown. Here, we studied the quality control mechanisms for the PMP22 mutants L16P and G150D, which were originally identified in mice and patients with CMT...
November 11, 2014: Scientific Reports
https://www.readbyqxmd.com/read/25149074/mir-139-5p-inhibits-migration-and-invasion-of-colorectal-cancer-by-downregulating-amfr-and-notch1
#15
Mingxu Song, Yuan Yin, Jiwei Zhang, Binbin Zhang, Zehua Bian, Chao Quan, Leyuan Zhou, Yaling Hu, Qifeng Wang, Shujuan Ni, Bojian Fei, Weili Wang, Xiang Du, Dong Hua, Zhaohui Huang
MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of the role of non-protein-coding RNAs in carcinogenesis and metastasis. In this study, we described the function and molecular mechanism of miR-139-5p in colorectal cancer (CRC) and its potential clinical application in CRC. We found that miR-139-5p was significantly downregulated in 73.8% CRC samples compared with adjacent noncancerous tissues (NCTs), and decreased miR-139-5p was associated with poor prognosis...
November 2014: Protein & Cell
https://www.readbyqxmd.com/read/24568530/aberrant-expression-of-the-autocrine-motility-factor-receptor-correlates-with-poor-prognosis-and-promotes-metastasis-in-gastric-carcinoma
#16
RANDOMIZED CONTROLLED TRIAL
Zhen Huang, Neng Zhang, Lang Zha, Hong-Chao Mao, Xuan Chen, Ji-Feng Xiang, Hua Zhang, Zi-Wei Wang
AMFR, autocrine motility factor receptor, also called gp78, is a cell surface cytokine receptor which has a dual role as an E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. AMFR expression is associated with tumor malignancy. We here investigated the clinical significance of AMFR and its role in metastasis and prognosis in gastric cancer. Expression of AMFR, E-cadherin and N-cadherin in cancer tissues and matched adjacent normal tissues from 122 gastric cancer (GC) patients undergoing surgical resection was assessed by immunohistochemistry...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23093786/micro-editing-mistake-translates-into-a-devastating-brain-tumor
#17
COMMENT
Dan Dominissini, Ninette Amariglio, Gideon Rechavi
RNA modifications are increasingly being recognized as critical players in cancer. While adenosine-to-inosine RNA editing is consistently deregulated in cancer, we are still unable to draw a straight line connecting transcript-specific editing and carcinogenesis. The findings by Choudhury et al. in this issue of the JCI bridge this gap by mechanistically implicating underediting of miR-376a* in promoting glioma invasiveness through redirection of its mRNA targets. Moreover, RAP2A and AMFR convincingly emerge as key regulators of glioma migration and invasion affected by deregulated microRNA editing...
November 2012: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/23093778/attenuated-adenosine-to-inosine-editing-of-microrna-376a-promotes-invasiveness-of-glioblastoma-cells
#18
Yukti Choudhury, Felix Chang Tay, Dang Hoang Lam, Edwin Sandanaraj, Carol Tang, Beng-Ti Ang, Shu Wang
In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster undergo programmed "seed" sequence modifications by adenosine-to-inosine (A-to-I) editing. Emerging evidence suggests a link between impaired A-to-I editing and cancer, particularly in high-grade gliomas. We hypothesized that disruption of A-to-I editing alters expression of genes regulating glioma tumor phenotypes. By sequencing the miR-376 cluster, we show that the overall miRNA editing frequencies were reduced in human gliomas...
November 2012: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/22328510/peripheral-endoplasmic-reticulum-localization-of-the-gp78-ubiquitin-ligase-activity
#19
Pascal St-Pierre, Thao Dang, Bharat Joshi, Ivan R Nabi
Gp78 (also known as AMFR and RNF45) is an E3 ubiquitin ligase that targets proteins for proteasomal degradation through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we showed that gp78-mediated ubiquitylation is initiated in the peripheral ER. Substrate monoubiquitylation and gp78 CUE domain integrity restricted substrate to the peripheral ER, where CUE domain interactions and polyubiquitylation reduced gp78 mobility. Derlin-1 and derlin-2, which are involved in the retrotranslocation of ERAD substrates, localized to a central, juxtanuclear ER domain, where polyubiquitylated proteins accumulated upon proteasome inhibition...
April 1, 2012: Journal of Cell Science
https://www.readbyqxmd.com/read/22313999/autocrine-motility-factor-receptor-is-involved-in-the-process-of-learning-and-memory-in-the-central-nervous-system
#20
Yong Yang, Xiao-Rui Cheng, Gui-Rong Zhang, Wen-Xia Zhou, Yong-Xiang Zhang
The autocrine motility factor receptor (AMFR) is a multifunctional protein involved in cellular adhesion, proliferation, motility and apoptosis. Our study showed that increased AMFR protein expression in the hippocampus of KM mice correlated with enhanced capacity for learning and memory following the shuttle-box test and was significantly elevated in the highest score group. Also, AMF and AMFR mRNA expression positively correlates with the mRNA expression of the synapse marker synaptophysin (Syp). Aging studies in the senescence-accelerated mouse strain (SAM) prone/8 (SAMP8), an animal model of Alzheimer's disease (AD), revealed significantly decreased mRNA and protein expression of AMF and AMFR in the hippocampus...
April 15, 2012: Behavioural Brain Research
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