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polypharmacy and elderly

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https://www.readbyqxmd.com/read/29792364/current-evidence-in-the-stability-of-medicines-in-dose-administration-aids-implications-for-patient-safety
#1
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow too. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs, as the result of a computerized search in databases (PubMed, Google Scholar, SciELO, and reference texts related to the field...
May 24, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29752625/polypharmacy-among-headache-patients-a-cross-sectional-study
#2
Anna Ferrari, Carlo Baraldi, Manuela Licata, Cecilia Rustichelli
BACKGROUND: Polypharmacy can appropriately treat multiple chronic conditions, but it can also increase potential harm. Polypharmacy information for primary headaches is minimal, despite drugs being the main tools to manage headaches. OBJECTIVE: The aim was to evaluate the prevalence, characteristics and risk factors of polypharmacy in patients with primary headaches and examine whether these variables differ between episodic and chronic headache patients. METHODS: We analysed polypharmacy (simultaneous use of five or more medications), medication type, comorbidity, and risk factors in 300 patients (mean age 42...
May 11, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29747709/polimedication-applicability-of-a-computer-tool-to-reduce-polypharmacy-in-nursing-homes
#3
Tomás M García-Caballero, Juan Lojo, Carlos Menéndez, Roberto Fernández-Álvarez, Raimundo Mateos, Alejandro Garcia-Caballero
ABSTRACTBackground:The risks of polypharmacy can be far greater than the benefits, especially in the elderly. Comorbidity makes polypharmacy very prevalent in this population; thus, increasing the occurrence of adverse effects. To solve this problem, the most common strategy is to use lists of potentially inappropriate medications. However, this strategy is time consuming. METHODS: In order to minimize the expenditure of time, our group devised a pilot computer tool (Polimedication) that automatically processes lists of medication providing the corresponding Screening Tool of Older Persons' potentially inappropriate Prescriptions alerts and facilitating standardized reports...
May 11, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29743832/management-of-inflammatory-bowel-disease-in-older-persons-evolving-paradigms
#4
REVIEW
Saurabh Kedia, Jimmy K Limdi, Vineet Ahuja
The incidence and prevalence of inflammatory bowel disease (IBD) is increasing, and considering the aging population, this number is set to increase further in the future. The clinical features and natural history of elderly-onset IBD have many similarities with those of IBD in younger patients, but with significant differences including a broader differential diagnosis. The relative lack of data specific to elderly patients with IBD, often stemming from their typical exclusion from clinical trials, has made clinical decision-making somewhat challenging...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29740921/hospitalization-and-morbidity-due-to-adverse-drug-reactions-in-elderly-patients-a-single-center-study
#5
Silvia Ognibene, Natale Vazzana, Claudio Giumelli, Luisa Savoldi, Luca Braglia, Giuseppe Chesi
BACKGROUND AND AIMS: Adverse drug reaction (ADRs) is a leading but underrecognized cause of illness particularly in frail subjects with multiple comorbidities. We aimed to investigate the frequency, patterns and outcomes of ADRs as a cause of hospitalization in elderly patients admitted to an internal medicine ward. METHODS: We performed a retrospective observational study including every patient aged over 65 years who was admitted to our Department during a 12-month period...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29730983/the-challenge-of-aging-and-pharmacoterapeutic-complexity-in-the-hiv-patient
#6
Ramón Morillo-Verdugo, José Ramón Blanco Ramos, Laila Abdel-Kader Martín, María Álvarez de Sotomayor
OBJECTIVE: To describe the current knowledge and management of aging and  pharmacotherapeutic complexity in HIV + patients. METHOD: A review of literature was carried out, including articles, originals or  reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms  «Polypharmacy»/»Polypharmacy», «Aging»/»Aging», «Frailty»/»Fragility»,  «Pharmacotherapeutic Complexity»/»Medication Regimen Complexity» and  «HIV»/"HIV» were combined...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29710004/-paradigm-shift-in-the-quality-of-regional-medical-care-cooperative-treatment-of-onychomycosis
#7
Junko Suzuki, Yoshihiro Imazu, Yoshitaka Yoneta, Katsunori Yamaura, Emiko Uchida
 In a superaging society, the medical paradigm should include both less coverage of medical-care work flow by human resources and high-quality care for patients. Strategies such as establishing medical-care teams and community medicine systems mainly for home medical care should be implemented. However, a well-organized system for home-based medical treatment of elderly patients is not yet in place, as evidenced by the lack of care, problems with long-term polypharmacy resulting from visits to multiple healthcare providers, and declines in their physical strength...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29692604/medication-related-risk-factors-associated-with-health-related-quality-of-life-among-community-dwelling-elderly-in-china
#8
Sha Zhang, Long Meng, Feng Qiu, Jia-Dan Yang, Shusen Sun
Background: Previous studies have demonstrated that medication adherence has an impact on health-related quality of life (HRQoL). However, other medication-related factors that may influence HRQoL have not been extensively studied, especially factors based on the Medication-Risk Questionnaire (MRQ), and such studies are mostly done in Western countries. Our objective was to explore risk factors associated with HRQoL among community-dwelling elderly with chronic diseases in mainland China, especially the medication-related risk factors regarding MRQ...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29689595/potentially-inappropriate-medication-use-in-older-patients-with-breast-and-colorectal-cancer
#9
Meghan S Karuturi, Holly M Holmes, Xiudong Lei, Michael Johnson, Carlos H Barcenas, Scott B Cantor, Gary E Gallick, Robert C Bast, Sharon H Giordano
BACKGROUND: The objective of this study was to determine patient characteristics associated with potentially inappropriate medication (PIM) use and its impact on outcomes for patients with breast or colorectal cancer receiving adjuvant chemotherapy. METHODS: The Surveillance, Epidemiology, and End Results database, linked to Medicare claims, was used. The cohort included patients who were 66 years old or older and were diagnosed with stage II or III breast or colorectal cancer between July 1, 2007, and December 31, 2009...
April 24, 2018: Cancer
https://www.readbyqxmd.com/read/29682764/how-confident-are-physicians-in-deprescribing-for-the-elderly-and-what-barriers-prevent-deprescribing
#10
L Djatche, S Lee, D Singer, S E Hegarty, M Lombardi, V Maio
WHAT IS KNOWN AND OBJECTIVE: Deprescribing is the process of discontinuing or reducing the dosage of medications that are no longer appropriate or aligned with goals of care, which is paramount in elderly patients with multiple comorbidities and polypharmacy. The objective of this study was to assess the perceptions of primary care physicians on deprescribing for elderly patients and potential barriers to deprescribing that physicians experience in the Local Health Authority (LHA) of Parma, Emilia-Romagna, Italy...
April 22, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29682231/frequency-of-dementia-among-elderly-admitted-to-a-geriatrics-inpatients-sector-of-a-brazilian-public-hospital
#11
Rafael Thomazi, Liciana Vaz de Arruda Silveira, Paulo José Fortes Villas Boas, Alessandro Ferrari Jacinto
Patients with dementia are commonly admitted to inpatient sectors. The aim of this study was to describe the frequency of dementia among elderly inpatients admitted to the Geriatrics Sector of a Brazilian Tertiary University Hospital, and to identify associations between dementia and clinical and sociodemographic factors. Methods: All patients admitted to the Geriatrics Sector of a public Brazilian university-hospital from March 1st 2014 to January 31st 2015 were assessed by geriatricians...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29665778/characteristics-of-elderly-patients-with-polypharmacy-who-refuse-to-participate-in-an-in-hospital-deprescribing-intervention-a-retrospective-cross-sectional-study
#12
Junpei Komagamine, Kenichi Sugawara, Kazuhiko Hagane
BACKGROUND: Few studies have evaluated the characteristics of elderly patients with polypharmacy refusing deprescribing. The aim of this study was to evaluate the prevalence of potentially inappropriate medication (PIM) use in elderly patients accepting and refusing a deprescribing intervention and to investigate factors associated with deprescribing refusal. METHODS: We conducted a retrospective cross-sectional study by analyzing the electronic medical records from a single hospital...
April 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29663152/a-glimpse-into-uveitis-in-the-aging-eye-pathophysiology-clinical-presentation-and-treatment-considerations
#13
REVIEW
Elizabeth Akinsoji, Raquel Goldhardt, Anat Galor
Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Some causes of uveitis in the elderly are herpes simplex virus, ocular ischemic syndrome, sarcoidosis, and central nervous system lymphoma, and these will be discussed in detail herein...
April 16, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29661337/thyroid-disorders-in-the-elderly-an-overall-summary
#14
REVIEW
Kevin Higgins
Medical care for elderly patients is often distinctly different from that of younger counterparts. This is no truer than in a thyroid disorder context, where patients are often asymptomatic and polypharmacy is a potential consideration. Understanding how treatment of these patients can deviate from common practices is an essential asset to any health care provider. The purpose of this article is to shed light on those deviations and address inherent complexities in caring for elderly patients in an effort to improve quality of care...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29661330/balance-disorders-in-older-adults
#15
REVIEW
David Eibling
Balance disorders are common in the elderly and can lead to falls, with resultant severe morbidity and even mortality. Progressive loss of vestibular function begins in middle age and is affected by multiple disease processes. Polypharmacy impacts many disease processes in the elderly, with balance function being one of the most susceptible. Evaluation of the older patient with a balance disorder is critical for the well-being of these patients, as it may drive intervention. This article reviews balance disorders often encountered in older patients and makes recommendations regarding education of nonotolaryngologists...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29594676/patient-and-health-professional-satisfaction-with-an-interdisciplinary-patient-safety-program
#16
Oreto Ruiz-Millo, Mónica Climente-Martí, José Ramón Navarro-Sanz
Background Measuring humanistic outcomes is an important component of valuating healthcare services. There is a paucity of data on satisfaction with pharmacist implemented clinical services in long-term care settings. Objective To evaluate patient and health professional (HP) satisfaction with an interdisciplinary patient safety program performed in elderly patients with polypharmacy admitted to a long-term care hospital (LTCH). Method An interventional, longitudinal, prospective study was conducted in a Spanish LTCH...
March 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29593860/potential-drug-drug-interactions-with-direct-oral-anticoagulants-in-elderly-hospitalized-patients
#17
Heather L Forbes, Thomas M Polasek
Background: To determine the prevalence and nature of potential drug-drug interactions (DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods: This was a retrospective observational study. Inclusion criteria were: aged over 65 years; taking apixaban, rivaroxaban or dabigatran; and admitted to the Repatriation General Hospital between April 2014 and July 2015. A list of clinically relevant 'perpetrator' drugs was compiled from product information, the Australian Medicines Handbook, the Australian National Prescribing Service resources, and local health network guidelines...
October 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29587356/dietary-patterns-and-their-relationship-with-frailty-in-functionally-independent-older-adults
#18
Mónica Machón, Maider Mateo-Abad, Kalliopi Vrotsou, Xabier Zupiria, Carolina Güell, Leonor Rico, Itziar Vergara
The impact of dietary patterns rather than single foods or nutrients on health outcomes is increasingly recognized. This cross-sectional study examines the dietary patterns of 527 non-institutionalized functionally independent older people aged ≥70 years from Gipuzkoa (Spain). Sociodemographic characteristics, health status, anthropometric measures and dietary data are collected. Multiple correspondence analysis (MCA) and cluster analysis are performed to identify dietary patterns and groups of individuals...
March 24, 2018: Nutrients
https://www.readbyqxmd.com/read/29582192/prevalence-and-risk-of-polypharmacy-among-elderly-cancer-patients-receiving-chemotherapy-in-ambulatory-oncology-setting
#19
REVIEW
Ivy Goh, Olive Lai, Lita Chew
PURPOSE OF REVIEW: This was a single center, retrospective cross-sectional study looking into the incidence and types of drug-related problems (DRPs) detected among elderly cancer patients receiving at least three long-term medications concurrent with IV chemotherapy, and the types of intervention taken to address these DRPs. This paper serves to elucidate the prevalence and risk of polypharmacy in our geriatric oncology population in an ambulatory care setting, to raise awareness on this growing issue and to encourage more resource allocation to address this healthcare phenomenon...
March 26, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29581817/medications-polypharmacy-influence-on-recurrent-fallers-in-community-a-systematic-review
#20
REVIEW
Yu Ming, Aleksandra Zecevic
The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1...
March 2018: Canadian Geriatrics Journal: CGJ
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