keyword
MENU ▼
Read by QxMD icon Read
search

Development

keyword
https://www.readbyqxmd.com/read/29787037/effects-of-perinatal-exposure-to-dibutyltin-chloride-on-fat-and-glucose-metabolism-in-mice-and-molecular-mechanisms-in-vitro
#1
Raquel Chamorro-García, Bassem M Shoucri, Sigal Willner, Heidi Käch, Amanda Janesick, Bruce Blumberg
BACKGROUND: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT during in utero development at relatively high doses, but little was known about the effects of DBT exposure at environmentally relevant doses on endpoints such as obesity and metabolic disease. OBJECTIVES: We tested the potential obesogenic effects of DBT using in vitro and in vivo models...
May 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29786974/embryonic-exposure-to-environmentally-relevant-concentrations-of-a-brominated-flame-retardant-reduces-the-size-of-song-control-nuclei-in-a-songbird
#2
Margaret L Eng, Viktoria Winter, John E Elliott, Scott A MacDougall-Shackleton, Tony D Williams
Environmental contaminants have the potential to act as developmental stressors and impair development of song and the brain of songbirds, but they have been largely unstudied in this context. 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) is a brominated flame retardant congener that has demonstrated endocrine disrupting effects, and has pervaded the global environment. We assessed the effects of in ovo exposure to environmentally relevant levels of BDE-99 on the neuroanatomy of the song-control system in a model songbird species, the zebra finch (Taeniopygia guttata)...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29786973/amniotic-fluid-lactic-acid-and-matrix-metalloproteinase-8-levels-at-the-time-of-fetal-surgery-for-a-spine-defect-association-with-subsequent-premature-preterm-rupture-of-membranes
#3
Antonio F Moron, Aikaterini Athanasiou, Mauricio Barbosa, Herbene J Milani, Stephanno G Sarmento, Sergio Cavalheiro, Steven S Witkin
OBJECTIVE: In utero fetal surgery to correct incomplete closure of the spinal cord lessens the extent of permanent damage but is associated with preterm premature rupture of membranes (pPROM). We determined if compounds in amniotic fluid (AF) collected at the time of surgery predicted subsequent development of pPROM. DESIGN: Prospective study. SETTING: Hospitals in Sao Paulo, Brazil. POPULATION: Twenty four consecutive pregnant women at 24-26 weeks gestation seen between February and October 2017 with a singleton pregnancy underwent in utero surgery to correct an open spinal defect in their fetus...
May 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29786969/hippocampal-lipidome-and-transcriptome-profile-alterations-triggered-by-acute-exposure-of-mice-to-gsm-1800-mhz-mobile-phone-radiation-an-exploratory-study
#4
Adamantia F Fragopoulou, Alexandros Polyzos, Maria-Despoina Papadopoulou, Anna Sansone, Areti K Manta, Evangelos Balafas, Nikolaos Kostomitsopoulos, Aikaterini Skouroliakou, Chryssostomos Chatgilialoglu, Alexandros Georgakilas, Dimitrios J Stravopodis, Carla Ferreri, Dimitris Thanos, Lukas H Margaritis
BACKGROUND: The widespread use of wireless devices during the last decades is raising concerns about adverse health effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted from these devices. Recent research is focusing on unraveling the underlying mechanisms of RF-EMR and potential cellular targets. The "omics" high-throughput approaches are powerful tools to investigate the global effects of RF-EMR on cellular physiology. METHODS: In this work, C57BL/6 adult male mice were whole-body exposed (nE xp  = 8) for 2 hr to GSM 1800 MHz mobile phone radiation at an average electric field intensity range of 4...
May 22, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29786967/developmental-chromatin-restriction-of-pro-growth-gene-networks-acts-as-an-epigenetic-barrier-to-axon-regeneration-in-cortical-neurons
#5
Ishwariya Venkatesh, Vatsal Mehra, Zimei Wang, Ben Califf, Murray G Blackmore
Axon regeneration in the central nervous system is prevented in part by a developmental decline in the intrinsic regenerative ability of maturing neurons. This loss of axon growth ability likely reflects widespread changes in gene expression, but the mechanisms that drive this shift remain unclear. Chromatin accessibility has emerged as a key regulatory mechanism in other cellular contexts, raising the possibility that chromatin structure may contribute to the age-dependent loss of regenerative potential. Here we establish an integrated bioinformatic pipeline that combines analysis of developmentally dynamic gene networks with transcription factor regulation and genome-wide maps of chromatin accessibility...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29786965/l-and-d-threo-ethylphenidate-concentrations-pharmacokinetics-and-pharmacodynamics-in-horses
#6
Heather K Knych, Dan S McKemie, Kelsey Seminoff, Petra Hartmann, Lynn Hovda, Dionne Benson
Ethylphenidate is a psychostimulant and analogue of the commonly prescribed compound, methylphenidate (Ritalin®). There are a limited number of studies describing the disposition and pharmacologic/toxicological effects of ethylphenidate in any species. The abuse potential in equine athletes along with the limited data available regarding administration in horses necessitates further study. The objectives of the current study were to describe drug concentrations, develop an analytical method that could be used to regulate its use and describe the pharmacodynamic effects of ethylphenidate in horses...
May 22, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29786964/a-thorough-qt-qtc-study-with-laquinimod-a-novel-immunomodulator-in-development-for-multiple-sclerosis-and-huntington-disease
#7
Ofer Spiegelstein, Dorit Mimrod, Laura Rabinovich, Eli Eyal, Craig Sprenger, Anna Elgart, Emil Samara, Joel Morganroth
In this randomized double-blind study, 4 groups of healthy subjects (50 per arm) participated to evaluate the effect of laquinimod, an oral treatment in development for multiple sclerosis and Huntington disease, on the QTc interval. Subjects received a dose of either 0.6 or 1.2 mg/day laquinimod for 14 days, placebo for 14 days, or 13 days of placebo followed by a dose of 400 mg moxifloxacin on day 14. Continuous 12-lead electrocardiograms were recorded on day -1 (baseline) and days 14 to 17,  and quadruplicate electrocardiograms were extracted at predefined time points...
May 22, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29786963/design-and-fabrication-of-printed-paper-based-hybrid-micro-supercapacitor-by-using-graphene-and-redox-active-electrolyte
#8
Bhawna Nagar, Deepak P Dubal, Luis Pires, Arben Merkoçi, Pedro Gómez-Romero
Inspired by future needs of flexible, simple, and low-cost energy storage devices, smart graphene-based micro-supercapacitors on conventional Xerox paper substrates were developed. The use of redox-active species (iodine redox couple) was explored to further improve the paper device's performance. The device based on printed graphene paper itself already had a remarkable maximum volumetric capacitance of 29.6 mF cm-3 (volume of whole device) at 6.5 mA cm-3 . The performance of the hybrid electrode with redox-active potassium iodide at the graphene surface was tested...
May 22, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29786960/the-atomic-resolution-structure-of-a-class-c-%C3%AE-lactamase-and-of-its-complex-with-avibactam
#9
Stefano Mangani, Cecilia Pozzi, Flavio Di Pisa, Filomena De Luca, Manuela Benvenuti, Jean-Denis Docquier
β-lactamases (BLs) are important antibiotic resistance determinants that significantly compromise the efficacy of valuable β-lactam antibacterial drugs. For that reason, combinations with β-lactamase inhibitor were developed. Avibactam is the first non-β-lactam BL inhibitor introduced in clinical practice. Ceftazidime-avibactam represents one of the few last-resort antibiotics available for the treatment of infections caused by near pandrug-resistant bacteria. TRU-1 is a chromosomally-encoded AmpC-type BL of Aeromonas enteropelogenes, related to the FOX-type BLs and constitutes a good model for class C BLs...
May 22, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29786957/statistical-approaches-to-adjusting-weights-for-dependent-arms-in-network-meta-analysis
#10
Yu-Xuan Su, Yu-Kang Tu
Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only one treatment. However, some trials use within person designs such as split-body, split-mouth and cross-over designs, where each patient may receive more than one treatment. Data from treatment arms within these trials are no longer independent, so the correlations between dependent arms need to be accounted for within the statistical analyses...
May 22, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29786953/iatrogenic-botulism-outbreak-in-egypt-due-to-a-counterfeit-botulinum-toxin-a-preparation-a-descriptive-series-of-patient-features-and-outcome
#11
Eman Abdel Monaem Abdel Rashid, Nashwa Mohamed El-Mahdy, Huda Shehata Kharoub, Ahmed Salah Gouda, Naglaa Ahmed ElNabarawy, Bruno Mégarbane
Iatrogenic botulism resulting from the substantial increase in use of botulinum neurotoxin type-A (BoNT-A) treatment is rarely reported. We aimed to describe a large iatrogenic botulism outbreak in Egypt in June-July 2017. Nine patients developed botulism after receiving intramuscular injections of BoNT-A (dose: 200-300 IU) to treat cerebral palsy (N=7), spastic dystonia (N=1), and hyperhidrosis (N=1). Detailed findings were available in 5/9 cases. Patients were admitted to the hospital 5-10 days after the BoNT-A injection...
May 22, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29786952/arabidopsis-sumo-protease-asp1-positively-regulates-aba-signaling-during-early-seedling-development
#12
Qiongli Wang, Gao-Ping Qu, Xiangxiong Kong, Yan Yan, Jigang Li, Jing Bo Jin
The small ubiquitin-related modifier (SUMO) modification plays an important role in the regulation of abscisic acid (ABA) signaling, but the function of the SUMO protease, in ABA signaling, remains largely unknown. Here, we show that the SUMO protease, ASP1 positively regulates ABA signaling. Mutations in ASP1 resulted in an ABA-insensitive phenotype, during early seedling development. Wild-type ASP1 successfully rescued, whereas an ASP1 mutant (C577S), defective in SUMO protease activity, failed to rescue, the ABA-insensitive phenotype of asp1-1...
May 22, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29786949/the-qsofa-score-a-simple-and-accurate-predictor-of-outcomes-in-patients-with-glyphosate-herbicide-poisoning
#13
Yongsoo Cho, Byeongjo Chun, Jeongmi Moon
This study aimed to investigate whether the quick Sequential Organ Failure Assessment (qSOFA) score at emergency department (ED) presentation can help improve the risk assessment of glyphosate-surfactant herbicide (GlySH) poisoning complications. A total of 150 patients presenting with acute glyphosate herbicide ingestion were enrolled in this retrospective observational study. The qSOFA scores at presentation, ΔqSOFA (calculated by subtracting the worst qSOFA score from 1 hr after admission from the qSOFA score at presentation), baseline characteristics, clinical courses and outcomes were collected and analysed...
May 22, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29786947/does-general-experience-affect-self-assessment
#14
Parisa Rezaiefar, Kelly Forse, Joseph K Burns, Sharon Johnston, Elizabeth Muggah, Claire Kendall, Douglas Archibald
BACKGROUND: The assessment of clinical competence is critical in medical education. Understanding the effect of general experience on a physician's self-assessment would help design more effective curricula and evaluations of procedural skills in postgraduate training and continuing professional development (CPD). In this observational study, we assessed the effect of general experience on the correlation between confidence and competence amongst experienced clinicians (ECs) and postgraduate trainees (PGTs) when learning an office-based procedure in pessary care...
May 22, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29786944/design-synthesis-and-evaluation-of-a-novel-series-of-inhibitors-reversing-p-glycoprotein-mediated-multidrug-resistance
#15
Hesham Ghaleb, Huilan Li, Mutta Kairuki, Qianqian Qiu, Xinzhou Bi, Chunxia Liu, Chen Liao, Jieming Li, Kamal Hezam, Wenlong Huang, Hai Qian
Multidrug resistance (MDR) is still the main barrier to attaining effective results with chemotherapy. Discovery of new chemo-reversal agents is needed to overcome MDR. Our study focused on a better way to obtain novel drugs with triazole rings that have an MDR-reversal ability through click chemistry. Among 20 developed compounds, compound 19 had a minimal cytotoxic effect compared to tariquidar and verapamil (VRP) and showed a higher reversal activity than VRP through increased accumulation in K562/A02 cells...
May 22, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29786922/finding-factors-that-predict-treatment-resistant-depression-results-of-a-cohort-study
#16
M Soledad Cepeda, Jenna Reps, Patrick Ryan
BACKGROUND: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought to identify factors that predict TRD in a real-world setting using claims databases. METHODS: A retrospective cohort study was conducted in a US claims database of adult subjects with newly diagnosed and treated depression with no mania, dementia, and psychosis...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29786918/novel-genes-and-insights-in-complete-asthma-remission
#17
Judith M Vonk, Maartje A E Nieuwenhuis, F Nicole Dijk, Anne Boudier, Valerie Siroux, Emmanuelle Bouzigon, Nicole Probst-Hensch, Medea Imboden, Dirk Keidel, Don Sin, Yohan Bossé, Ke Hao, Maarten van den Berge, Alen Faiz, Gerard H Koppelman, Dirkje S Postma
BACKGROUND: Asthma is a chronic respiratory disease without a cure, though there exists spontaneous remission. Genome wide association(GWA) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission. OBJECTIVES: We performed a GWA study to develop insights in asthma remission. METHODS: Clinical remission (ClinR) was defined by absence of asthma treatment and wheezing in the last year and asthma attacks in the last 3 years, and complete remission (ComR) similarly but additionally with normal lung function and absence of bronchial hyperresponsiveness (BHR)...
May 22, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29786917/a-strategy-of-self-isolated-enhanced-emission-to-achieve-highly-emissive-dual-state-emission-for-organic-luminescent-materials
#18
Yanzi Xu, Lin Ren, Dongfeng Dang, Ying Zhi, Xiaochi Wang, Lingjie Meng
Currently, the commonly developed organic luminescent materials (OLMs) usually exhibit poor luminescent performance in aggregated solid states compared with their well-dissolved solution states, making it a tough goal to achieve the highly emissive dual-state emission. To overcome this limitation, "Self-Isolated Enhanced Emission" (SIEE) strategy through flexible alkyl chains to suppress the emission-quenched π-π stacking in solids is proposed here and based on this guideline, remarkable emission efficiency with photoluminescence quantum yields up to 99...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29786914/conductive-hydrogels-as-smart-materials-for-flexible-electronic-devices
#19
Qinfeng Rong, Wenwei Lei, Mingjie Liu
Flexible conductive materials have gained considerable research interest in recent years because of their potential applications in flexible energy storage devices, sensors, touch panels, electronic-skins, etc. With excellent flexibility, outstanding electric properties and tunable mechanical properties, conductive hydrogels as conductive materials offer plentiful insights and opportunities for flexible electronic devices. Numerous synthetic strategies have been developed to obtain various conductive hydrogels, and high-performance devices based on these conductive hydrogels have been realized...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29786913/new-insights-into-the-anion-transport-selectivity-and-mechanism-of-tren-based-tris-thio-ureas
#20
Laura Jowett, Ethan Howe, Xin Wu, Nathalie Busschaert, Philip Alan Gale
The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange...
May 22, 2018: Chemistry: a European Journal
keyword
keyword
5492
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"